OMIM :  602216

GENECARD : STK11

CGAP : 301772

• LKB1

• PJS

• serine/threonine kinase 11 (Peutz-Jeghers syndrome)

• Serine/threonine protein kinase 11; STK11

Clinical

• Clinical genetics of multiple endocrine neoplasias, Carney complex and related syndromes. Stratakis CA.

• Prevention of pancreatic cancer and strategies for management of familial pancreatic cancer. Hruban RH, Canto MI, Yeo CJ.

Oncogenecity

• STK11/LKB1 plays a role in the pathogenesis of several cancers, including pancreatic adenocarcinoma. Sato N, Rosty C, Jansen M, Fukushima N, Ueki T, Yeo CJ, Cameron JL, Iacobuzio-Donahue CA, Hruban RH, Goggins M.

Phenotype

• Genetic mutations in STK11/LKB1 to pancreatic cancer in patients with the Peutz-Jeghers Syndrome (PJS). Hruban RH, Petersen GM, Goggins M, Tersmette AC, Offerhaus GJ, Falatko F, Yeo CJ, Kern SE.

Tumor gene type

• Inactivation of the STK11/LKB1, a tumor-suppressor gene responsible pathogenesis of pancreatic adenocarcinoma. Sato N, Rosty C, Jansen M, Fukushima N, Ueki T, Yeo CJ, Cameron JL, Iacobuzio-Donahue CA, Hruban RH, Goggins M.

• Allelic imbalance in PJS polyps, suggesting that LKB1 acts as a tumour suppressor in these tumours. Wang ZJ, Ellis I, Zauber P, Iwama T, Marchese C, Talbot I, Xue WH, Yan ZY, Tomlinson I.

Tumor incidence

• A germline mutation in IPMN that arose in a patient with PJS and a somatic mutation in 1 of the 20 sporadic IPMNs. Sato N, Rosty C, Jansen M, Fukushima N, Ueki T, Yeo CJ, Cameron JL, Iacobuzio-Donahue CA, Hruban RH, Goggins M.

• PJS patients are at increased risk of benign and malignant tumors of the pancreas .Rowan A, Bataille V, MacKie R, Healy E, Bicknell D, Bodmer W, Tomlinson I.