OMIM :  605587

GENECARD : SERPINI2

CGAP : 158308

• pancpin
• PANCPIN
• protease inhibitor 14 (pancpin)
• MEPI
• serine (or cysteine) proteinase inhibitor, clade I (neuroserpin), member 2
• TSA2004
• TAS2004
• PI14

Biochemical type

• Pancpin showing a high degree of similarity to serine protease inhibitors belonging to the serpin superfamily. Ozaki K, Nagata M, Suzuki M, Fujiwara T, Miyoshi Y, Ishikawa O, Ohigashi H, Imaoka S, Takahashi E, Nakamura Y.

Chromosome human

• A novel serpin gene cluster at 3q26 containing the pancreas-specific protease inhibitor, pancpin (PI14). Chang WS, Chang NT, Lin SC, Wu CW, Wu FY.

DNA structure

• PI14 and PI12 at 3q26 were found to consist of 9 exons and 8 introns. Chang WS, Chang NT, Lin SC, Wu CW, Wu FY.

• Pancpin contained an open reading frame of 1,215 nucleotides. Ozaki K, Nagata M, Suzuki M, Fujiwara T, Miyoshi Y, Ishikawa O, Ohigashi H, Imaoka S, Takahashi E, Nakamura Y.

Oncogenecity

• Down-regulation of pancpin expression may play a significant role in development or progression of pancreatic cancer. Ozaki K, Nagata M, Suzuki M, Fujiwara T, Miyoshi Y, Ishikawa O, Ohigashi H, Imaoka S, Takahashi E, Nakamura Y.

Protein size

• Pancpin is a 405 amino acid protein. Ozaki K, Nagata M, Suzuki M, Fujiwara T, Miyoshi Y, Ishikawa O, Ohigashi H, Imaoka S, Takahashi E, Nakamura Y.