OMIM :  118445

GENECARD : CCKBR

CGAP : 203

Chromosome human

• The CCKB receptor gene, on the other hand, resides on a syntenic region of human chromosome 11 and distal mouse chromosome 7. Huppi K, Siwarski D, Pisegna JR, Wank

• Localization of the human cholecystokinin-B/gastrin receptor gene (CCKBR) to chromosome 11p15.5-->p15.4 by fluorescence in situ hybridization. Zimonjic DB, Popescu NC, Matsui T, Ito M, Chihara K.
  

• The gene contained a 1356-bp open reading frame consisting of five exons interrupted by 4 introns and was assigned to human chromosome 11p15.4. Song I, Brown DR, Wiltshire RN, Gantz I, Trent JM, YamadaT.

DNA Structure

• Cloning and characterization of 5'-end alternatively spliced human cholecystokinin-B receptor mRNAs. Monstein HJ, Nilsson I, Ellnebo-Svedlund K, Svensson SP.

• The gene contained a 1356-bp open reading frame consisting of five exons interrupted by 4 introns and was assigned to human chromosome 11p15.4. Song I, Brown DR, Wiltshire RN, Gantz I, Trent JM, Yamada T

Function

• Transfected cholecystokinin receptors mediate growth inhibitory effects on human pancreatic cancer cell lines. Detjen K, Fenrich MC, Logsdon CD.

• Temporal expression of the gastrin (CCK-B) receptor during azaserine-induced pancreatic carcinogenesis. Povoski SP, Zhou W, Longnecker DS, Bell RH Jr.

Homologue

• The CCKB receptor gene, on the other hand, resides on a syntenic region of human chromosome 11 and distal mouse chromosome 7. Huppi K, Siwarski D, Pisegna JR, Wank S. 

Oncogenic activation

• CCK-B receptors have been found in some human pancreatic cancers. Andren-Sandberg A, Hoem D, Backman PL.

• Human pancreatic cancer cell lines express the CCKB receptor. de Weerth A, von Schrenck T, Lohr M, Mirau S, Greten H, Kalthoff H.

• CCKB receptor-connected effector systems have been characterized in MIA-PaCA-2 cells. Kaufmann R, Schafberg H, Rudroff C, Henklein P, Nowak G.

Regulation

• Pancreatic cancer cells express CCK-B/gastrin receptor and gastrin precursor forms in most patients. Caplin M, Savage K, Khan K, Brett B, Rode J, Varro A, Dhillon A.

• A blockade of the CCK-A and CCK-B receptors by their antagonists led to an increased, an unaffected, or a decreased cell number of the cell lines.OhlssonB, Fredang N, AxelsonJ.