Genes previously mapped to the region have been
located on the contig, and we have isolated eight transcripts, two of
which have been characterized as the genes CPETR1 and CPETR2. Hockenhull
EL, Carette MJ, Metcalfe K, Donnai D, Read AP,Tassabehji M.
Our findings suggest that targeting
claudin-4-expressing tumors with CPE represents a promising new
treatment modality for pancreatic cancer and other solid tumors. Michl
P, Buchholz M, Rolke M, Kunsch S, Lohr M, McClane B, Tsukita S, Leder
G, Adler G, Gress TM.
Multiple claudin family members are involved in
the formation of TJ strands in various tissues. Morita
K, Furuse M, Fujimoto K, Tsukita S.
Regulated expression of claudin-4 decreases
paracellular conductance through a selective decrease in sodium
Itallie C, Rahner C, Anderson JM.
The human RVP1 homologue showed differences in
affinity and capacity of binding from those of the human CPE receptor.
J, Sugiyama H, Inoue N, Horiguchi Y, Matsuda M, Sugimoto N
Expression analyses showed that claudin-4 was
overexpressed in most pancreatic cancer tissues and cell lines and
several other gastrointestinal tumors.
Michl P, Buchholz M, Rolke M, Kunsch S, Lohr M, McClane B, Tsukita
S,Leder G, Adler G, Gress TM.