OMIM :  601153

GENECARD : FHIT

CGAP : 77252

• The FHIT gene is expressed in pancreatic ductular cells and is altered in pancreatic cancers. Sorio C, Baron A, Orlandini S, Zamboni G, Pederzoli P, Huebner K, Scarpa A.

Chromosome, Human

• The FHIT gene is localized on chromosome 3p14. Simon B, Bartsch D, Barth P, Prasnikar N, Munch K, Blum A, Arnold R, Goke B.

Clinical

• Molecular pathobiology of pancreatic adenocarcinoma. Mangray S, King TC.

Function

• Fragile histidine triad expression delays tumor development and induces apoptosis in human pancreatic cancer. Dumon KR, Ishii H, Vecchione A, Trapasso F, Baldassarre G, Chakrani F, Druck T, Rosato EF, Williams NN, Baffa R, During MJ, Huebner K, Croce CM.

Gene Frequency (Tumors)

• Frequent abnormalities of the putative tumor suppressor gene FHIT at 3p14.2 in pancreatic carcinoma cell lines. Simon B, Bartsch D, Barth P, Prasnikar N, Munch K, Blum A, Arnold R, Goke B.

Tumor Gene Type

• Alterations of the candidate tumor suppressor gene FHIT have been reported in multiple tumor types, including pancreatic carcinoma. Hilgers W, Koerkamp BG, Geradts J, Tang DJ, Yeo CJ, Hruban RH, Kern SE.

• The fragile histidine triad (FHIT) gene is a tumor suppressor gene. Dumon KR, Ishii H, Vecchione A, Trapasso F, Baldassarre G, Chakrani F, Druck T, Rosato EF, Williams NN, Baffa R, During MJ, Huebner K, Croce CM.