OMIM :  137250

GENECARD : GAS

CGAP : 2681

Function

Gastrin regulates growth of human pancreatic cancer in a tonic and autocrine fashion. Smith JP, Shih A, Wu Y, McLaughlin PJ, Zagon IS.

Molecular mechanisms for the growth factor action of gastrin. Todisco A, Takeuchi Y, Urumov A, Yamada J, Stepan VM, Yamada T.

Homologue

Molecular structure and genetic mapping of the mouse gastrin gene. Friis-Hansen L, Rourke IJ, Bundgaard JR, Rehfeld JF, Samuelson LC.

Oncogenicity

Gastrin regulates growth of human pancreatic cancer in a tonic and autocrine fashion. Smith JP, Shih A, Wu Y, McLaughlin PJ, Zagon IS. 

Closing the gastrin loop in pancreatic carcinoma: coexpression of gastrin and its receptor in solid human pancreatic adenocarcinoma.. Goetze JP, Nielsen FC, Burcharth F, Rehfeld JF.

Regulation

Activation of gastrin gene transcription in islet cells by a RAP1-like cis-acting promoter element. Simon B, Tillotson L, Brand SJ.

Activation of gastrin transcription in pancreatic insulinoma cells by a CACC promoter element and a 70-kDa sequence-specific DNA-binding protein. Tillotson LG, Wang TC, Brand SJ.

Signaling Pathway

Molecular mechanisms for the growth factor action of gastrin. Todisco A, Takeuchi Y, Urumov A, Yamada J, Stepan VM, Yamada T.