OMIM :  600797

GENECARD : IRS2

CGAP : 143648

Biochemical type         

• Insulin receptor substrate-2 (IRS-2) is a multisite docking protein… Kornmann M, Maruyama H, Bergmann U, Tangvoranuntakul P, Beger HG, White MF, Korc M.

Function

• IRS-2 may contribute to enhanced mitogenic signaling via the PI 3-kinase pathway. Kornmann M, Maruyama H, Bergmann U, Tangvoranuntakul P, Beger HG, White MF, Korc M.

Oncogenicity

• Enhanced expression of the insulin receptor substrate-2 docking protein in human pancreatic cancer. Kornmann M, Maruyama H, Bergmann U, Tangvoranuntakul P, Beger HG, White MF, Korc M.

Regulation

• Insulin, IGF-I, and IGF-II enhanced the growth of both cell lines, stimulated tyrosine phosphorylation of IRS-2, and increased IRS-2-associated phosphatidylinositol (PI) 3-kinase activity. Kornmann M, Maruyama H, Bergmann U, Tangvoranuntakul P, Beger HG, White MF, Korc M.

Signaling Pathway

• IRS-2 may contribute to enhanced mitogenic signaling via the PI 3-kinase pathway. Kornmann M, Maruyama H, Bergmann U, Tangvoranuntakul P, Beger HG, White MF, Korc M.