OMIM :  185250

GENECARD : MMP3

CGAP : 83326

Biochemical type

• Expression of mRNAs encoding extracellular matrix components (collagens I, III and IV, laminin, fibronectin), extracellular matrix-degrading metalloproteinases (MMP-1, -2, -3 and -9) and tissue inhibitors of metalloproteinases (TIMP-1 and -2) in pancreatic cancer. Gress TM, Muller-Pillasch F, Lerch MM, Friess H, Buchler M, Adler G.

Function

• Extracellular matrix-degrading metalloproteinases (MMP-1, -2, -3 and –9). Gress TM, Muller-Pillasch F, Lerch MM, Friess H, Buchler M, Adler G.

Oncogenicity

• MMP2, MMP3 and TIMP1 in the invasive phenotype of pancreatic and ampullary cancer. Bramhall SR, Stamp GW, Dunn J, Lemoine NR, Neoptolemos JP.