[BiO BB] computational mutagenesis
dmb at mrc-dunn.cam.ac.uk
Wed Mar 10 18:38:47 EST 2004
I heard about a technique called 'computational alanine scanning' which
simulates an experimental technique to probe protein-protein interaction
(I think). Sounds like a good thing to play with / compare with other
On Wed, 10 Mar 2004, Dana Reichmann wrote:
> Iddo hi,
> thanks for the suggestion, i'll check it,
> I am more interesting on evaluation of changes upon mutation (structure
> and thermodynamic changes) when the structure of a wild type complex is
> known. Something similar to FOLDEFF program (from L.Serrano group) or
> Rosetta from D. Baker.
> On Mar 10, 2004, at 7:50 PM, Iddo Friedberg wrote:
> > Dana,
> > Have you looked at the CAPRI site (http://capri.ebi.ac.uk/)
> > and papers in Proteins?
> > (http://www3.interscience.wiley.com/cgi-bin/jissue/104531597)
> > Iddo
> > Dana Reichmann wrote:
> >> Hi all,
> >> I am looking for good programs and algorithms for computational
> >> mutagenesis that can define hot spots in *protein-protein
> >> *interactions. I am interesting in different approach such as
> >> thermodynamical, structural etc. I want to understand what kind of
> >> approach are better, what is maximal prediction % of each.
> >> Thanks a lot,
> >> Dana
> > --
> > Iddo Friedberg, Ph.D.
> > The Burnham Institute
> > 10901 N. Torrey Pines Rd.
> > La Jolla, CA 92037
> > USA
> > Tel: +1 (858) 646 3100 x3516
> > Fax: +1 (858) 713 9930
> > http://ffas.ljcrf.edu/~iddo
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