[BiO BB] difference between Refseq and Uniprot

Stefanie Lager stefanielager at fastmail.ca
Mon Jun 27 02:08:17 EDT 2005

It's redundancy both in Uniprot and In Refseq. Refseq contain splice
variants but no fragments, it has good coverage. While SwissProt doesn't
contain fragments or spice variants, but the coverage isn't quite as
good. But TrEMBL does contain fragments and  splice variants. For a few
species the IPI database could be an alternative
http://www.ebi.ac.uk/IPI/IPIhelp.html  . It's a mergeer of UniProt,
RefSeq and Ensembl. IPI has good coverage, and it contains splice
variants, but few fragments.


> Hi, all,
> Recently,  I am working on the protein sequence analysis.  I found the
> Refseq is very different from Uniprot.  Uniprot contains much more
> proteins if TrEMBL is included.  Can any experts give some comments on
> these two protein database.  Which one is more reliable?   It seems
> Swiss is of the best quality, then Refseq, then TrEMBL.   And also, It
> seems there are redundancy in Uniprot.  Is that so?
> -Frank
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