[BiO BB] Withdrawl of Refseq accessions

Ann Loraine aloraine at gmail.com
Tue Jun 6 22:58:05 EDT 2006

Howdy again,

Regarding multiple releases of the human genome:

In some ways this is a good thing, because, in theory, newer releases
improve upon the previous.

And...well...they create greater need for bioinformatics professionals
such as ourselves.

Also, think about how the human genome is assembled. At every stage,
decisions must be made. Are they the best? And for what purpose?

And remember .... someday soon the $1,000 genome sequence will be upon
us. How will we handle *that* ?

How we will we handle the inevitable deletions, duplications, and
(easy!) single-base pair changes these data will introduce into our
vision of the genome?


On 6/6/06, Michael Muratet US-Huntsville <Michael.Muratet at operon.com> wrote:
> Ryan & Hilmar
> Thanks for the help. I checked the transcript stable ID tables over past
> releases of Ensembl to see how may IDs were created/terminated and it looked
> to be in the hundreds (but not thousands). I thought it might be a one-time
> transient at Refseq. It still seems like a lot to me given that we're now on
> the third or fourth 'final' release of the human genome as you noted, and
> I'll start processing each new release to see what's changed.
> Thanks,
> Mike
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Ann Loraine
Assistant Professor
Section on Statistical Genetics
University of Alabama at Birmingham

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