[BiO BB] BLOCKS motifs and protein protein interactions

Boris Steipe boris.steipe at utoronto.ca
Wed Sep 17 10:55:27 EDT 2008

No, that inference is not generally possible. Only if the proteins  
are very(!) closely related.
Google "interologs" for background on the limits of annotation  
transfer for interacting proteins.


On 15-Sep-07, at 6:57 PM, Mahmoud Elhefnawi wrote:

> Dear all,
> I was wandering if BLOCKS database homology hits with significant e  
> values habe been correlated before  to infer protein protein  
> interactions?
> i.e" if protein A interacts with protein B, and protein C has a  
> significant match with protein B, then protein C also interacts  
> with protein A???
> Best,
> Mahmoud
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