[BiO BB] Difference between Protein Interaction Network (PIN) and Protein-Protein Interaction Network (PPIN)

[Dan Bolser]

2008/12/23 Ashwathy <ashwathy.bl at gmail.com>:
> dear friends,
> please help me to find answer to some queries....
>
> Is there any difference between Protein Interaction Network (PIN) and
> Protein-Protein Interaction Network (PPIN) ?
> If so please help me to find what the difference is..

No, its just two different names for the same idea.


> and also,
> is there any advantages other than finding the connectivity of the protein,
> by investigating the PIN? I mean whether it is possible to explore the
> attributes (both structural and functional) of a protein through it's PIN?

Yes, there are lots of ideas. For example, some people say that highly
connected proteins are more likely to be essential, or evolve slower.
The 'guilt by association' method is a way to infer protein function
or structure from the known function or structure of its interacting
partners. There are lots of papers (sorry I didn't reference any
here).

Dan.


> Aswathi
> Centre for Bioinformatics
> Kerala University
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