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<div align="center"><font face="Arial" size="+3"
color="#000000"><b>Computational Methods in Systems
Biology</b></font></div>
<div align="center"><font face="Arial" size="+3"
color="#000000">University of Trento</font></div>
<div align="center"><font face="Arial" size="+3" color="#000000">24-26
February, 2003 Rovereto, Italy</font></div>
<div align="center"><font face="Arial" size="+3"
color="#000000">www.science.unitn.it/~priami/cmsb.html</font></div>
<div><font face="Arial" size="+3" color="#000000"><br></font></div>
<div><font face="Arial" size="+3" color="#000000"><br></font></div>
<div><font face="Arial" size="+2" color="#000000">Molecular biology
has until now mainly focussed on individual molecules, on their
properties as isolated entities or as complexes in very simple model
systems. However, biological molecules in living systems participate
in very complex networks, including regulatory networks for gene
expression, intracellular metabolic networks and both intra- and
intercellular communication networks. Such networks are involved in
the maintenance (homeostasis) as well as the differentiation of
cellular systems of which we have a very incomplete understanding.<br>
Nevertheless, the progress of molecular biology has made possible the
detailed description of the components that constitute living systems,
notably genes and proteins. Large scale genome sequencing means that
we can (at least in principle) delimneate all macromolecular
components of a given cellular system, and microarray experiments as
well as large scale proteomics will soon give us large amounts of
experimental data on gene regulation, molecular interactions and
cellular networks. The challenge of the 21st century will be to
understand how these individual components integrate to complex
systems and the function and evolution of these systems, thus scaling
up from molecular biology to systems biology. By combining
experimental data with advanced formal theories from computer science,
"the formal language for biological systems" to specify
dynamic models of interacting molecular entities would be essential
for<br>
1. understanding normal behaviour of cellular processes, and how
changes may affect the processes and cause disease. It may be possible
to correlate genetic properties and symptoms in new and more efficient
ways, based on an actual understanding of how various processes
interact.</font></div>
<div><font face="Arial" size="+2" color="#000000">2. Providing
predictability and flexibility to academic, pharmaceutical,
biotechnology and medical researchers studying gene or protein
functions. In particular, it may save time by reducing the number of
experiments needed, if inadequate hypotheses could be excluded by
computer simulation.<br>
<br>
Topics of interest include, but are not limited to:<br>
<br>
</font><font face="Symbol" size="+2" color="#000000">…</font><font
face="Arial" size="+2" color="#000000"> Modelling languages for
Systems Biology<br>
</font><font face="Symbol" size="+2" color="#000000">…</font><font
face="Arial" size="+2" color="#000000"> Concurrency theory in Systems
Biology<br>
</font><font face="Symbol" size="+2" color="#000000">…</font><font
face="Arial" size="+2" color="#000000"> Constraint programming in
Systems Biology<br>
</font><font face="Symbol" size="+2" color="#000000">…</font><font
face="Arial" size="+2" color="#000000"> Logical methods in Systems
Biology<br>
</font><font face="Symbol" size="+2" color="#000000">…</font><font
face="Arial" size="+2" color="#000000"> Formal methods to analyse
biomolecular systems<br>
</font><font face="Symbol" size="+2" color="#000000">…</font><font
face="Arial" size="+2" color="#000000"> Quantitative analysis of
biomolecular systems<br>
</font><font face="Symbol" size="+2" color="#000000">…</font><font
face="Arial" size="+2" color="#000000"> Simulation techniques for
Systems Biology</font></div>
<div><font face="Symbol" size="+3" color="#000000">…</font><font
face="Arial" size="+2" color="#000000"> Case studies</font><br>
</div>
<div><font face="Arial" size="+2" color="#000000"><b>IMPORTANT
DATES</b><br>
<br>
</font><font face="Symbol" size="+2" color="#000000">…</font><font
face="Arial" size="+2" color="#000000"> Nov 9, 2002 Submission
deadline for papers and demos<br>
</font><font face="Symbol" size="+2" color="#000000">…</font><font
face="Arial" size="+2" color="#000000"> Nov 30, 2002
Notification of acceptance<br>
</font><font face="Symbol" size="+2" color="#000000">…</font><font
face="Arial" size="+2" color="#000000"> Dec 16, 2002
Camera-ready version due</font><br>
</div>
<div><font face="Arial" size="+2"
color="#000000"><b>PROCEEDINGS</b><br>
The proceedings will be published in the Springer LNCS series and will
be available at the workshop.</font><br>
</div>
<div><font face="Arial" size="+2"
color="#000000"><b>SUBMISSION</b></font></div>
<div><font face="Arial" size="+2" color="#000000">Authors are invited
to submit .ps or .pdf original research papers as well as survey or
tutorial papers of no more than 12 pages in LNCS format
(see</font></div>
<div align="center"><font face="Arial" size="+2"
color="#000000">http://www.springer.de/comp/lncs/authors.html</font></div
>
<div><font face="Arial" size="+2" color="#000000">for instructions) at
the address</font></div>
<div align="center"><font face="Arial" size="+2"
color="#000000">concini@dit.unitn.it</font></div>
<div><font face="Arial" size="+2" color="#000000">For further
information please contact us at the addresses
[concini,priami]@dit.unitn.it. The papers will pass a peer review
process and the accepted ones will appear in the
proceedings.</font><br>
</div>
<div><font face="Arial" size="+2" color="#000000">I<b>NVITED
SPEAKERS</b><br>
<br>
</font><font face="Symbol" size="+2" color="#000000">…</font><font
face="Arial" size="+2" color="#000000"> Ehud Shapiro, Weizmann
Institute of Science, Israel<br>
</font><font face="Symbol" size="+2" color="#000000">…</font><font
face="Arial" size="+2" color="#000000"> To be announced</font><br>
</div>
<div><font face="Arial" size="+2" color="#000000"><b>PROGRAMME
COMMITTEE</b><br>
<br>
</font><font face="Symbol" size="+2" color="#000000">…</font><font
face="Arial" size="+2" color="#000000"> Charles Auffray, CNRS,
Villejuif (F)<br>
</font><font face="Symbol" size="+2" color="#000000">…</font><font
face="Arial" size="+2" color="#000000"> Cosima Baldari, Università
di Siena (I)<br>
</font><font face="Symbol" size="+2" color="#000000">…</font><font
face="Arial" size="+2" color="#000000"> Alexander Bockmayr, Université
Henri Poincaré, Nancy (F)<br>
</font><font face="Symbol" size="+2" color="#000000">…</font><font
face="Arial" size="+2" color="#000000"> Luca Cardelli, Microsoft
Research Cambridge (UK)<br>
</font><font face="Symbol" size="+2" color="#000000">…</font><font
face="Arial" size="+2" color="#000000"> Vincent Danos, Université
Paris VII (F)<br>
</font><font face="Symbol" size="+2" color="#000000">…</font><font
face="Arial" size="+2" color="#000000"> Pierpaolo Degano, Università
di Pisa (I)<br>
</font><font face="Symbol" size="+2" color="#000000">…</font><font
face="Arial" size="+2" color="#000000"> François Fages, INRIA
Rocquencourt (F)<br>
</font><font face="Symbol" size="+2" color="#000000">…</font><font
face="Arial" size="+2" color="#000000"> Drabløs Finn, , Norwegian
University of Science and Technology, Trondheim (N)<br>
</font><font face="Symbol" size="+2" color="#000000">…</font><font
face="Arial" size="+2" color="#000000"> Monika Heiner, Brandenburg
University of Technology at Cottbus - (D)<br>
</font><font face="Symbol" size="+2" color="#000000">…</font><font
face="Arial" size="+2" color="#000000"> Ina Koch, University of
Applied Sciences Berlin, (D).<br>
</font><font face="Symbol" size="+2" color="#000000">…</font><font
face="Arial" size="+2" color="#000000"> John E. Ladbury, University
College London (UK)</font></div>
<div><font face="Symbol" size="+2" color="#000000">…</font><font
face="Arial" size="+2" color="#000000"> Patrick Lincoln, SRI (USA)<br>
</font><font face="Symbol" size="+2" color="#000000">…</font><font
face="Arial" size="+2" color="#000000"> Satoru Miyano, University of
Tokyo (JP)<br>
</font><font face="Symbol" size="+2" color="#000000">…</font><font
face="Arial" size="+2" color="#000000"> Gordon Plotkin, University of
Edinburgh (UK)<br>
</font><font face="Symbol" size="+2" color="#000000">…</font><font
face="Arial" size="+2" color="#000000"> Simon Plyte, Pharmacia
Corporation (I)<br>
</font><font face="Symbol" size="+2" color="#000000">…</font><font
face="Arial" size="+2" color="#000000"> Corrado Priami (CHAIR),
Università di Trento (I)<br>
</font><font face="Symbol" size="+2" color="#000000">…</font><font
face="Arial" size="+2" color="#000000"> Aviv Regev, Weizmann Institute
of Science (IL)<br>
</font><font face="Symbol" size="+2" color="#000000">…</font><font
face="Arial" size="+2" color="#000000"> Magali Roux-Rouquié, BSMI
Pasteur Institute (F)<br>
</font><font face="Symbol" size="+2" color="#000000">…</font><font
face="Arial" size="+2" color="#000000"> Vincent Schachter,
Hybrigenics Paris (F)<br>
</font><font face="Symbol" size="+2" color="#000000">…</font><font
face="Arial" size="+2" color="#000000"> Masaru Tomita, Keio University
(JP)<br>
</font><font face="Symbol" size="+2" color="#000000">…</font><font
face="Arial" size="+2" color="#000000"> Adelinde Uhrmacher, University
of Rostock (D)<br>
</font><font face="Symbol" size="+2" color="#000000">…</font><font
face="Arial" size="+2" color="#000000"> Alfonso Valencia, CNB-CSIC
Centro Nacional de Biotecnologia, Cantoblanco Madrid, (E)<br>
</font><font face="Symbol" size="+2" color="#000000">…</font><font
face="Arial" size="+2" color="#000000"> Olaf Wolkenhauer, UMIST,
Manchester (UK)</font><br>
</div>
<div><font face="Arial" size="+2" color="#000000"><b>ORGANIZING
COMMITTEE</b></font><br>
<font face="Arial" size="+2" color="#000000"></font></div>
<div><font face="Arial" size="+2" color="#000000">Linda Brodo, Michela
de Concini, Corrado Priami, Debora Schuch da Rosa Machado</font></div>
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