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<p class=MsoNormal align=center style='margin-right:.25in;margin-bottom:0in;
margin-left:176.0pt;margin-bottom:.0001pt;text-align:center;text-autospace:
none'><b><font size=6 color=black face="TimesNewRoman,Bold"><span
style='font-size:28.0pt;font-family:"TimesNewRoman\,Bold";color:black;
font-weight:bold'> </span></font></b></p>
<p class=MsoNormal style='margin-right:.25in;margin-bottom:0in;margin-left:
176.0pt;margin-bottom:.0001pt;text-align:justify;text-autospace:none'><b><font
size=3 color=black face="TimesNewRoman,Bold"><span style='font-size:12.0pt;
font-family:"TimesNewRoman\,Bold";color:black;font-weight:bold'>Dear
Bioinformatics.org, </span></font></b></p>
<p class=MsoNormal style='margin-right:.25in;margin-bottom:0in;margin-left:
176.0pt;margin-bottom:.0001pt;text-align:justify;text-autospace:none'><b><font
size=3 color=black face="TimesNewRoman,Bold"><span style='font-size:12.0pt;
font-family:"TimesNewRoman\,Bold";color:black;font-weight:bold'> </span></font></b></p>
<p class=MsoNormal style='margin-right:.25in;margin-bottom:0in;margin-left:
176.0pt;margin-bottom:.0001pt;text-align:justify;text-autospace:none'><b><font
size=3 color=black face="TimesNewRoman,Bold"><span style='font-size:12.0pt;
font-family:"TimesNewRoman\,Bold";color:black;font-weight:bold'>Bellow you will
find information on an upcoming course to take place at UCSD Extension, on July
6-8, 2005</span></font></b></p>
<p class=MsoNormal style='margin-right:.25in;margin-bottom:0in;margin-left:
176.0pt;margin-bottom:.0001pt;text-align:justify;text-autospace:none'><b><font
size=3 color=black face="TimesNewRoman,Bold"><span style='font-size:12.0pt;
font-family:"TimesNewRoman\,Bold";color:black;font-weight:bold'> </span></font></b></p>
<p class=MsoNormal style='margin-right:.25in;margin-bottom:0in;margin-left:
176.0pt;margin-bottom:.0001pt;text-align:justify;text-autospace:none'><b><font
size=3 color=black face="TimesNewRoman,Bold"><span style='font-size:12.0pt;
font-family:"TimesNewRoman\,Bold";color:black;font-weight:bold'>I have also
attached a PDF file with the same information:</span></font></b></p>
<p class=MsoNormal style='margin-right:.25in;margin-bottom:0in;margin-left:
176.0pt;margin-bottom:.0001pt;text-align:justify;text-autospace:none'><b><font
size=3 color=black face="TimesNewRoman,Bold"><span style='font-size:12.0pt;
font-family:"TimesNewRoman\,Bold";color:black;font-weight:bold'>If you have any
questions or concerns please feel free to contact me.</span></font></b></p>
<p class=MsoNormal style='margin-right:.25in;margin-bottom:0in;margin-left:
176.0pt;margin-bottom:.0001pt;text-align:justify;text-autospace:none'><b><font
size=3 color=black face="TimesNewRoman,Bold"><span style='font-size:12.0pt;
font-family:"TimesNewRoman\,Bold";color:black;font-weight:bold'> </span></font></b></p>
<p class=MsoNormal style='margin-right:.25in;margin-bottom:0in;margin-left:
176.0pt;margin-bottom:.0001pt;text-align:justify;text-autospace:none'><b><font
size=3 color=black face="TimesNewRoman,Bold"><span style='font-size:12.0pt;
font-family:"TimesNewRoman\,Bold";color:black;font-weight:bold'>Thank you,</span></font></b></p>
<p class=MsoNormal style='margin-right:.25in;margin-bottom:0in;margin-left:
176.0pt;margin-bottom:.0001pt;text-align:justify;text-autospace:none'><b><font
size=3 color=black face="TimesNewRoman,Bold"><span style='font-size:12.0pt;
font-family:"TimesNewRoman\,Bold";color:black;font-weight:bold'> </span></font></b></p>
<p class=MsoNormal style='margin-right:.25in;margin-bottom:0in;margin-left:
176.0pt;margin-bottom:.0001pt;text-align:justify;text-autospace:none'><b><font
size=3 color=black face="TimesNewRoman,Bold"><span style='font-size:12.0pt;
font-family:"TimesNewRoman\,Bold";color:black;font-weight:bold'>Essy</span></font></b></p>
<p class=MsoNormal align=center style='margin-right:.25in;margin-bottom:0in;
margin-left:176.0pt;margin-bottom:.0001pt;text-align:center;text-autospace:
none'><b><font size=6 color=black face="TimesNewRoman,Bold"><span
style='font-size:28.0pt;font-family:"TimesNewRoman\,Bold";color:black;
font-weight:bold'> </span></font></b></p>
<p class=MsoNormal align=center style='margin-right:.25in;margin-bottom:0in;
margin-left:176.0pt;margin-bottom:.0001pt;text-align:center;text-autospace:
none'><b><font size=6 color=black face="TimesNewRoman,Bold"><span
style='font-size:22.0pt;font-family:"TimesNewRoman\,Bold";color:black;
font-weight:bold'> </span></font></b></p>
<p class=MsoNormal align=center style='margin-right:.25in;margin-bottom:0in;
margin-left:176.0pt;margin-bottom:.0001pt;text-align:center;text-autospace:
none'><b><font size=6 color=black face="TimesNewRoman,Bold"><span
style='font-size:22.0pt;font-family:"TimesNewRoman\,Bold";color:black;
font-weight:bold'>Systems Biology & Bioengineering </span></font></b></p>
<p class=MsoNormal align=center style='margin-right:.25in;margin-bottom:0in;
margin-left:176.0pt;margin-bottom:.0001pt;text-align:center;text-autospace:
none'><font size=6 color=black face=TimesNewRoman><span style='font-size:22.0pt;
font-family:TimesNewRoman;color:black'>July 6-8, 2005</span></font><font
size=6 color=black face=TimesNewRoman><span style='font-size:22.0pt;font-family:
TimesNewRoman;color:black'> </span></font></p>
<p class=MsoNormal align=center style='margin-right:.25in;margin-bottom:0in;
margin-left:176.0pt;margin-bottom:.0001pt;text-align:center;text-autospace:
none'><font size=6 color=black face="TimesNewRoman,Bold"><span
style='font-size:22.0pt;font-family:"TimesNewRoman\,Bold";color:black'> </span></font></p>
<p class=MsoNormal align=center style='margin-right:322.0pt;margin-bottom:0in;
margin-left:21.0pt;margin-bottom:.0001pt;text-align:center;text-autospace:none'><b><i><font
size=3 color=black face="Arial,BoldItalic"><span style='font-size:12.0pt;
font-family:"Arial\,BoldItalic";color:black;font-weight:bold;font-style:italic'>Gain
an advanced understanding </span></font></i></b></p>
<p class=MsoNormal align=center style='margin-right:322.0pt;margin-bottom:0in;
margin-left:21.0pt;margin-bottom:.0001pt;text-align:center;text-autospace:none'><b><i><font
size=3 color=black face="Arial,BoldItalic"><span style='font-size:12.0pt;
font-family:"Arial\,BoldItalic";color:black;font-weight:bold;font-style:italic'>of
the cutting-edge field of Systems Biology! </span></font></i></b></p>
<p class=MsoNormal align=center style='margin-right:322.0pt;margin-bottom:0in;
margin-left:21.0pt;margin-bottom:.0001pt;text-align:center;text-autospace:none'><font
size=2 color=black face="TimesNewRoman,Bold"><span style='font-size:10.0pt;
font-family:"TimesNewRoman\,Bold";color:black'> </span></font></p>
<p class=MsoNormal style='margin-right:322.0pt;margin-bottom:0in;margin-left:
21.0pt;margin-bottom:.0001pt;text-autospace:none'><b><font size=2 color=black
face="Arial,Bold"><span style='font-size:10.0pt;font-family:"Arial\,Bold";
color:black;font-weight:bold'>Dr. Bernhard Palsson</span></font></b><font
size=2 color=black face=Arial><span style='font-size:10.0pt;font-family:Arial;
color:black'>, renowned scientist and professor of Bioengineering at UCSD,
partners with UCSD Extension's Bioscience Department to present this </span></font><font
size=2 color=blue face=Arial><span style='font-size:10.0pt;font-family:Arial;
color:blue'>3-day intensive <u>course </u></span></font><font size=2
color=black face=Arial><span style='font-size:10.0pt;font-family:Arial;
color:black'>focused on helping current university faculty, life-science
researchers, and others gain an advanced understanding of the cutting-edge
field of systems biology. Through the combination of lecture and lab based
instruction, participants will explore the molecular- and engineering-levels of
biology and gain a thorough understanding of the developments in this new
field. </span></font></p>
<p class=MsoNormal style='margin-right:322.0pt;margin-bottom:0in;margin-left:
21.0pt;margin-bottom:.0001pt;text-autospace:none'><font size=2 color=black
face="TimesNewRoman,Bold"><span style='font-size:10.0pt;font-family:"TimesNewRoman\,Bold";
color:black'> </span></font></p>
<p class=MsoNormal style='margin-right:322.0pt;margin-bottom:0in;margin-left:
21.0pt;margin-bottom:.0001pt;text-autospace:none'><b><font size=2 color=black
face="Arial,Bold"><span style='font-size:10.0pt;font-family:"Arial\,Bold";
color:black;font-weight:bold'>The course focuses on: </span></font></b></p>
<p class=MsoNormal style='margin-right:322.0pt;margin-bottom:0in;margin-left:
21.0pt;margin-bottom:.0001pt;text-autospace:none'><font size=2 color=black
face=SymbolMT><span style='font-size:10.0pt;font-family:SymbolMT;color:black'>•
</span></font><font size=2 color=black face=Arial><span style='font-size:10.0pt;
font-family:Arial;color:black'>Reconstructing biochemical reaction networks
using heterogeneous data sources </span></font></p>
<p class=MsoNormal style='margin-right:322.0pt;margin-bottom:0in;margin-left:
21.0pt;margin-bottom:.0001pt;text-autospace:none'><font size=2 color=black
face=SymbolMT><span style='font-size:10.0pt;font-family:SymbolMT;color:black'>•
</span></font><font size=2 color=black face=Arial><span style='font-size:10.0pt;
font-family:Arial;color:black'>Characterizing the topological properties of the
reconstructed networks </span></font></p>
<p class=MsoNormal style='margin-right:322.0pt;margin-bottom:0in;margin-left:
21.0pt;margin-bottom:.0001pt;text-autospace:none'><font size=2 color=black
face=SymbolMT><span style='font-size:10.0pt;font-family:SymbolMT;color:black'>•
</span></font><font size=2 color=black face=Arial><span style='font-size:10.0pt;
font-family:Arial;color:black'>Determining the functional states of networks
and how to compare computation with experimental results </span></font></p>
<p class=MsoNormal style='margin-right:322.0pt;margin-bottom:0in;margin-left:
21.0pt;margin-bottom:.0001pt;text-autospace:none'><font size=2 color=black
face="TimesNewRoman,Bold"><span style='font-size:10.0pt;font-family:"TimesNewRoman\,Bold";
color:black'> </span></font></p>
<p class=MsoNormal style='margin-right:322.0pt;margin-bottom:0in;margin-left:
21.0pt;margin-bottom:.0001pt;text-autospace:none'><b><font size=2 color=black
face="Arial,Bold"><span style='font-size:10.0pt;font-family:"Arial\,Bold";
color:black;font-weight:bold'>The program includes: </span></font></b></p>
<p class=MsoNormal style='margin-right:322.0pt;margin-bottom:0in;margin-left:
21.0pt;margin-bottom:.0001pt;text-autospace:none'><font size=2 color=black
face=SymbolMT><span style='font-size:10.0pt;font-family:SymbolMT;color:black'>•
</span></font><font size=2 color=black face=Arial><span style='font-size:10.0pt;
font-family:Arial;color:black'>The various high-throughput data types, how they
are generated, and interpreted </span></font></p>
<p class=MsoNormal style='margin-right:322.0pt;margin-bottom:0in;margin-left:
21.0pt;margin-bottom:.0001pt;text-autospace:none'><font size=2 color=black
face=SymbolMT><span style='font-size:10.0pt;font-family:SymbolMT;color:black'>•
</span></font><font size=2 color=black face=Arial><span style='font-size:10.0pt;
font-family:Arial;color:black'>The heterogeneous high-throughput data types and
how they are used to reconstruct cellular reaction networks </span></font></p>
<p class=MsoNormal style='margin-right:322.0pt;margin-bottom:0in;margin-left:
21.0pt;margin-bottom:.0001pt;text-autospace:none'><font size=2 color=black
face=SymbolMT><span style='font-size:10.0pt;font-family:SymbolMT;color:black'>•
</span></font><font size=2 color=black face=Arial><span style='font-size:10.0pt;
font-family:Arial;color:black'>The representation of network reconstructions as
chemically and genetically structured databases </span></font></p>
<p class=MsoNormal style='margin-right:322.0pt;margin-bottom:0in;margin-left:
21.0pt;margin-bottom:.0001pt;text-autospace:none'><font size=2 color=black
face=SymbolMT><span style='font-size:10.0pt;font-family:SymbolMT;color:black'>•
</span></font><font size=2 color=black face=Arial><span style='font-size:10.0pt;
font-family:Arial;color:black'>The way to mathematically represent
reconstructed networks </span></font></p>
<p class=MsoNormal style='margin-right:322.0pt;margin-bottom:0in;margin-left:
21.0pt;margin-bottom:.0001pt;text-autospace:none'><font size=2 color=black
face=SymbolMT><span style='font-size:10.0pt;font-family:SymbolMT;color:black'>•
</span></font><font size=2 color=black face=Arial><span style='font-size:10.0pt;
font-family:Arial;color:black'>The capabilities and properties of networks and
how they are analyzed </span></font></p>
<p class=MsoNormal style='margin-right:322.0pt;margin-bottom:0in;margin-left:
21.0pt;margin-bottom:.0001pt;text-autospace:none'><font size=2 color=black
face=SymbolMT><span style='font-size:10.0pt;font-family:SymbolMT;color:black'>•
</span></font><font size=2 color=black face=Arial><span style='font-size:10.0pt;
font-family:Arial;color:black'>Analyzing the structural, steady state and
dynamic properties of networks </span></font></p>
<p class=MsoNormal style='margin-right:322.0pt;margin-bottom:0in;margin-left:
21.0pt;margin-bottom:.0001pt;text-autospace:none'><font size=2 color=black
face=SymbolMT><span style='font-size:10.0pt;font-family:SymbolMT;color:black'>•
</span></font><font size=2 color=black face=Arial><span style='font-size:10.0pt;
font-family:Arial;color:black'>The public and commercial software packages are
used for such analysis </span></font></p>
<p class=MsoNormal style='margin-right:322.0pt;margin-bottom:0in;margin-left:
21.0pt;margin-bottom:.0001pt;text-autospace:none'><font size=2 color=black
face="TimesNewRoman,Bold"><span style='font-size:10.0pt;font-family:"TimesNewRoman\,Bold";
color:black'> </span></font></p>
<p class=MsoNormal style='margin-right:30.0pt;margin-bottom:0in;margin-left:
21.0pt;margin-bottom:.0001pt;text-autospace:none'><b><font size=2 color=black
face="Arial,Bold"><span style='font-size:10.0pt;font-family:"Arial\,Bold";
color:black;font-weight:bold'>Date/Time: </span></font></b><font
size=2 color=black face=Arial><span style='font-size:10.0pt;font-family:Arial;
color:black'>July 6-8, 2005</span></font><font size=2 color=black face=Arial><span
style='font-size:10.0pt;font-family:Arial;color:black'> </span></font><font size=2 color=black face=Arial><span style='font-size:10.0pt;font-family:Arial;
color:black'>8:00 a.m.-5:00 p.m.</span></font><font size=2 color=black
face=Arial><span style='font-size:10.0pt;font-family:Arial;color:black'> </span></font><b><font
size=2 color=black face="Arial,Bold"><span style='font-size:10.0pt;font-family:
"Arial\,Bold";color:black;font-weight:bold'>Location: </span></font></b><font
size=2 color=black face=Arial><span style='font-size:10.0pt;font-family:Arial;
color:black'>UCSD Extension, </span></font><font size=2 color=black face=Arial><span
style='font-size:10.0pt;font-family:Arial;color:black'>Sorrento</span></font><font
size=2 color=black face=Arial><span style='font-size:10.0pt;font-family:Arial;
color:black'> </span></font><font size=2 color=black face=Arial><span
style='font-size:10.0pt;font-family:Arial;color:black'>Mesa</span></font><font
size=2 color=black face=Arial><span style='font-size:10.0pt;font-family:Arial;
color:black'> </span></font><font size=2 color=black face=Arial><span
style='font-size:10.0pt;font-family:Arial;color:black'>Center</span></font><font
size=2 color=black face=Arial><span style='font-size:10.0pt;font-family:Arial;
color:black'> Cingular Wireless Building Room </span></font><font size=2
color=black face=Arial><span style='font-size:10.0pt;font-family:Arial;
color:black'>112 6925 Lusk Blvd.</span></font><font size=2 color=black
face=Arial><span style='font-size:10.0pt;font-family:Arial;color:black'> </span></font><font
size=2 color=black face=Arial><span style='font-size:10.0pt;font-family:Arial;
color:black'>San Diego</span></font><font size=2 color=black face=Arial><span
style='font-size:10.0pt;font-family:Arial;color:black'>, </span></font><font
size=2 color=black face=Arial><span style='font-size:10.0pt;font-family:Arial;
color:black'>CA</span></font><font size=2 color=black face=Arial><span
style='font-size:10.0pt;font-family:Arial;color:black'> </span></font><font
size=2 color=black face=Arial><span style='font-size:10.0pt;font-family:Arial;
color:black'>92121</span></font><font size=2 color=black face=Arial><span
style='font-size:10.0pt;font-family:Arial;color:black'> </span></font><b><font
size=2 color=black face="Arial,Bold"><span style='font-size:10.0pt;font-family:
"Arial\,Bold";color:black;font-weight:bold'>Fee: </span></font></b><font
size=2 color=black face=Arial><span style='font-size:10.0pt;font-family:Arial;
color:black'>$1195 </span></font></p>
<p class=MsoNormal style='margin-right:30.0pt;margin-bottom:0in;margin-left:
323.0pt;margin-bottom:.0001pt;text-autospace:none'><font size=2 color=black
face=Arial><span style='font-size:10.0pt;font-family:Arial;color:black'>(Includes
continental breakfast, lunch, and course materials.) </span></font></p>
<p class=MsoNormal style='margin-right:30.0pt;text-autospace:none'><b><u><font
size=2 color=blue face="Arial,Bold"><span style='font-size:10.0pt;font-family:
"Arial\,Bold";color:blue;font-weight:bold'><span style='text-decoration:none'> </span></span></font></u></b></p>
<p class=MsoNormal style='margin-right:30.0pt;text-autospace:none'><b><u><font
size=2 color=blue face="Arial,Bold"><span style='font-size:10.0pt;font-family:
"Arial\,Bold";color:blue;font-weight:bold'>Bernhard Palsson, Ph.D.</span></font></u></b><font
size=2 color=black face=Arial><span style='font-size:10.0pt;font-family:Arial;
color:black'>, is a Professor of Bioengineering and Adjunct Professor Medicine
at UCSD. He is an inventor of over 20 </span></font><font size=2 color=black
face=Arial><span style='font-size:10.0pt;font-family:Arial;color:black'>U.S.</span></font><font
size=2 color=black face=Arial><span style='font-size:10.0pt;font-family:Arial;
color:black'> patents, many of which are in the area of hematopoietic stem cell
transplantation, bioreactor design, gene transfer, high-throughput single cell
manipulation, network reconstruction, in silico model building and metabolic
engineering. He is the founder/co-founder of: AASTROM BIOSCIENCES, ONCOSIS,
CYNTELLECT, GENOMATICA, and the Iceland Genomics Corporation. </span></font></p>
<p class=MsoNormal style='margin-right:30.0pt;margin-bottom:0in;margin-left:
323.0pt;margin-bottom:.0001pt;text-autospace:none'><font size=2 color=black
face="TimesNewRoman,Bold"><span style='font-size:10.0pt;font-family:"TimesNewRoman\,Bold";
color:black'> </span></font></p>
<p class=MsoNormal style='margin-right:398.0pt;margin-bottom:0in;margin-left:
21.0pt;margin-bottom:.0001pt;text-autospace:none'><b><font size=2 color=black
face="Arial,Bold"><span style='font-size:10.0pt;font-family:"Arial\,Bold";
color:black;font-weight:bold'>Information: </span></font></b></p>
<p class=MsoNormal style='margin-right:398.0pt;margin-bottom:0in;margin-left:
21.0pt;margin-bottom:.0001pt;text-autospace:none'><font size=2 color=black
face=Arial><span style='font-size:10.0pt;font-family:Arial;color:black'>Call Essy
Levy at (858)-622-5736 or e-mail </span></font><u><font size=2 color=blue
face=Arial><span style='font-size:10.0pt;font-family:Arial;color:blue'>etlevy@ucsd.edu</span></font></u><font
size=2 color=black face=Arial><span style='font-size:10.0pt;font-family:Arial;
color:black'>. </span></font></p>
<p class=MsoNormal style='margin-right:398.0pt;margin-bottom:0in;margin-left:
21.0pt;margin-bottom:.0001pt;text-autospace:none'><b><font size=2 color=black
face="Arial,Bold"><span style='font-size:10.0pt;font-family:"Arial\,Bold";
color:black;font-weight:bold'>To enroll: </span></font></b><font size=2
color=black face=Arial><span style='font-size:10.0pt;font-family:Arial;
color:black'>Call (858)-534-3400 or visit </span></font><u><font size=2
color=blue face=Arial><span style='font-size:10.0pt;font-family:Arial;
color:blue'>www.extension.ucsd.edu/registration</span></font></u><font size=2
color=black face=Arial><span style='font-size:10.0pt;font-family:Arial;
color:black'>. Section ID #: 051129 </span></font></p>
<p class=MsoNormal style='text-autospace:none'><font size=3
face="TimesNewRoman,Bold"><span style='font-size:12.0pt;font-family:"TimesNewRoman\,Bold"'> </span></font></p>
<p class=MsoNormal><font size=3 face="Times New Roman"><span style='font-size:
12.0pt'> </span></font></p>
<p class=MsoNormal><font size=2 face=Arial><span style='font-size:10.0pt;
font-family:Arial'> </span></font></p>
<p class=MsoNormal><font size=2 face=Arial><span style='font-size:10.0pt;
font-family:Arial'> </span></font></p>
<p class=MsoAutoSig><font size=3 face="Times New Roman"><span style='font-size:
12.0pt'>Essy Levy M.S.</span></font></p>
<p class=MsoAutoSig><font size=3 face="Times New Roman"><span style='font-size:
12.0pt'>Bioscience Programs Coordinator</span></font></p>
<p class=MsoAutoSig><font size=3 face="Times New Roman"><span style='font-size:
12.0pt'>UCSD Extension Bioscience</span></font></p>
<p class=MsoAutoSig><font size=3 face="Times New Roman"><span style='font-size:
12.0pt'>858-622-5736</span></font></p>
<p class=MsoAutoSig><font size=3 face="Times New Roman"><span style='font-size:
12.0pt'>etlevy@ucsd.edu</span></font></p>
<p class=MsoNormal><font size=3 face="Times New Roman"><span style='font-size:
12.0pt'>http://bioscience.ucsd.edu</span></font></p>
<p class=MsoNormal><font size=3 face="Times New Roman"><span style='font-size:
12.0pt'> </span></font></p>
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