hi Tim,<br><br>Are these predicted genes in the same reading frame, or is there a frameshift between them?<br><br>Best regards,<br>Marty<br><br><div><span class="gmail_quote">On 12/14/05, <b class="gmail_sendername">Timothy Driscoll
</b> <<a href="mailto:molvisions@mac.com">molvisions@mac.com</a>> wrote:</span><blockquote class="gmail_quote" style="border-left: 1px solid rgb(204, 204, 204); margin: 0pt 0pt 0pt 0.8ex; padding-left: 1ex;">hi,<br>
<br>how prevalent is gene overlap in prokaryote genomes? not just a few<br>codons at one end, but large regions of overlap, sometimes as long as<br>the complete gene. I have recently begun curating the genome of a<br>Gram-negative bacteria. I am finding a lot of predicted overlapping
<br>genes (Genemark, Glimmer, RefSeq), often with roughly equivalent<br>supporting evidence in favor of both genes (Blast hits, RBS, codon<br>bias, etc.).<br><br>I have been told that overlapping genes are uncommon, and never more
<br>than about 30 codons in the overlap. but I am unable to find any data<br>to support this. can anyone please provide some helpful references?<br><br>many thanks,<br><br>tim<br>--<br>Timothy Driscoll em:
<a href="mailto:molvisions@mac.com">molvisions@mac.com</a><br>molvisions - see. grasp. learn. ph: 919-368-2667<br><<a href="http://www.molvisions.com/">http://www.molvisions.com/</a>> im: molvisions
<br>usa:virginia:blacksburg tx: <a href="mailto:molvisions@vtext.com">molvisions@vtext.com</a><br><br><br><br><br><br>_______________________________________________<br>Bioinformatics.Org general forum -
<a href="mailto:BiO_Bulletin_Board@bioinformatics.org">BiO_Bulletin_Board@bioinformatics.org</a><br><a href="https://bioinformatics.org/mailman/listinfo/bio_bulletin_board">https://bioinformatics.org/mailman/listinfo/bio_bulletin_board
</a><br></blockquote></div><br><br clear="all"><br>-- <br>-- <br>Martin Gollery<br>Associate Director<br>Center For Bioinformatics<br>University of Nevada at Reno<br>Dept. of Biochemistry / MS330<br>775-784-7042<br>-----------