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<P><FONT SIZE=2 FACE="Courier New">Hi All,</FONT>
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<P><FONT SIZE=2 FACE="Courier New">I have a simple problem, I hope someone can advice.</FONT>
<BR><FONT SIZE=2 FACE="Courier New">I needed to make a covalent bond between a sugar molecule and an aminoacid</FONT>
<BR><FONT SIZE=2 FACE="Courier New">>(aa-COOH + sugar-OH --> H2O + aa-sugar).</FONT>
<BR><FONT SIZE=2 FACE="Courier New">I had them in a single pdb file and managed to generate a pdb file with a covalent bond, but the geometry of this resulting molecule is very distorted.</FONT></P>
<P><FONT SIZE=2 FACE="Courier New">I now need to optimize this geometry and I think that energy minimization shouwl be able to take care of that.</FONT>
<BR><FONT SIZE=2 FACE="Courier New">I have previously used insightII for this energy minimization but do not access to it anymore.</FONT>
<BR><FONT SIZE=2 FACE="Courier New">Is there any software avaibale (free for academic use) that should be able to do this.</FONT>
<BR><FONT SIZE=2 FACE="Courier New">I did a google search and find quite a few but cannot decide which one to start with, because each would have a learning curve.</FONT></P>
<P><FONT SIZE=2 FACE="Courier New">Please suggest something that you think is more popular/optimal. </FONT>
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<P><FONT SIZE=2 FACE="Courier New">Thanks for any help.</FONT>
<BR><FONT SIZE=2 FACE="Courier New">-Manisha Goel</FONT>
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<P><FONT SIZE=2 FACE="Courier New">Post-doc associate</FONT>
<BR><FONT SIZE=2 FACE="Courier New">Stowers Institute for Medical Research</FONT>
<BR><FONT SIZE=2 FACE="Courier New">1000 E 50th St.</FONT>
<BR><FONT SIZE=2 FACE="Courier New">Kansas city, 64110</FONT>
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