<HTML><BODY style="word-wrap: break-word; -khtml-nbsp-mode: space; -khtml-line-break: after-white-space; "><P class="MsoNormal" style="text-align: justify;margin-top: 0in; margin-right: 1in; margin-bottom: 12pt; margin-left: 0in; "><SPAN style=""><FONT class="Apple-style-span" face="ArialMT" size="5"><SPAN class="Apple-style-span" style="font-size: 17.3333px;">The Reactome Knowledgebase group (Cold Spring Harbor Lab and the European Bioinformatics Institute) is proud to announce the release of Reactome Version 17 today, </SPAN></FONT><SPAN style="mso-spacerun: yes"><FONT class="Apple-style-span" face="ArialMT" size="5"><SPAN class="Apple-style-span" style="font-size: 17.3333px;"> </SPAN></FONT></SPAN><FONT class="Apple-style-span" face="ArialMT" size="5"><SPAN class="Apple-style-span" style="font-size: 17.3333px;">accessible at </SPAN></FONT><A href="http://www.reactome.org/"><SPAN style="text-decoration: none; "><FONT class="Apple-style-span" color="#0039DA" face="ArialMT" size="5"><SPAN class="Apple-style-span" style="font-size: 17.3333px;">http://www.reactome.org</SPAN></FONT></SPAN></A><FONT class="Apple-style-span" face="ArialMT" size="5"><SPAN class="Apple-style-span" style="font-size: 17.3333px;">!</SPAN></FONT></SPAN><SPAN style=""><FONT class="Apple-style-span" face="ArialMT" size="5"><SPAN class="Apple-style-span" style="font-size: 17.3333px;"><O:P></O:P></SPAN></FONT></SPAN></P><P class="MsoNormal" style="text-align: justify;margin-top: 0in; margin-right: 1in; margin-bottom: 12pt; margin-left: 0in; "><SPAN style=""><FONT class="Apple-style-span" face="ArialMT" size="5"><SPAN class="Apple-style-span" style="font-size: 17.3333px;">Reactome is a curated knowledgebase of biological processes in humans. It covers processes ranging from basic pathways of metabolism to complex events such as hormonal signaling and apoptosis. The information in Reactome is provided by expert bench biologists, and edited and managed as a relational database by the Reactome staff. New material is peer-reviewed and revised as necessary before publication to the web. Reactome entries are linked to corresponding ones in NCBI EntrezGene, RefSeq, OMIM, Ensembl genome annotations, UCSC Genome Browser, KEGG, ChEBI and Gene Ontology (GO).</SPAN></FONT></SPAN><SPAN style=""><FONT class="Apple-style-span" face="ArialMT" size="5"><SPAN class="Apple-style-span" style="font-size: 17.3333px;"><O:P></O:P></SPAN></FONT></SPAN></P><P class="MsoNormal" style="text-align: justify;margin-top: 0in; margin-right: 1in; margin-bottom: 12pt; margin-left: 0in; "><SPAN style=""><FONT class="Apple-style-span" face="ArialMT" size="5"><SPAN class="Apple-style-span" style="font-size: 17.3333px;">New modules include signaling cascades mediated by TGF-beta, RIG-I, and Toll-like receptors 3 and 4, the conjugation phase of xenobiotic metabolism, aspects of the metabolism of lipoproteins, <SPAN style="">cell cycle regulation by the anaphase-promoting complex (APC),</SPAN> and ATR activation in response to replication stress. The total number of curated human reactions in the knowledgebase is now 1828 and the total number of annotated human proteins is 1369.</SPAN></FONT></SPAN><SPAN style=""><FONT class="Apple-style-span" face="ArialMT" size="5"><SPAN class="Apple-style-span" style="font-size: 17.3333px;"><O:P></O:P></SPAN></FONT></SPAN></P><P class="MsoNormal" style="text-align: justify;margin-top: 0in; margin-right: 1in; margin-bottom: 12pt; margin-left: 0in; "><SPAN style=""><FONT class="Apple-style-span" face="ArialMT" size="5"><SPAN class="Apple-style-span" style="font-size: 17.3333px;">New software features in version 17 include an upgraded SkyPainter tool, which now shows all reactions involving proteins in a user-specified list highlighted on the Reactome reaction map, lists these reactions in downloadable tabular form, and identifies pathways that are statistically over-represented for a list of specified proteins. As before, Reactome data can be exported in SMBL, Protégé, and BioPAX level 2 formats.</SPAN></FONT></SPAN><SPAN style=""><FONT class="Apple-style-span" face="ArialMT" size="5"><SPAN class="Apple-style-span" style="font-size: 17.3333px;"><O:P></O:P></SPAN></FONT></SPAN></P><SPAN style=""><FONT class="Apple-style-span" face="ArialMT" size="5"><SPAN class="Apple-style-span" style="font-size: 17.3333px;">Like everything in Reactome, these downloaded and exported materials can be reused and redistributed freely. For questions and comments, please reply to this message or write to <A href="mailto:help@reactome.org">help@reactome.org</A></SPAN></FONT></SPAN> <DIV><FONT class="Apple-style-span" face="ArialMT" size="5"><SPAN class="Apple-style-span" style="font-size: 17.3333px;"><BR class="khtml-block-placeholder"></SPAN></FONT></DIV><DIV><FONT class="Apple-style-span" face="ArialMT" size="5"><SPAN class="Apple-style-span" style="font-size: 17.3333px;">-Reactome teams at CSHL and EBI</SPAN></FONT></DIV></BODY></HTML>