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<DIV dir=ltr align=left><SPAN class=136124614-02052006><FONT color=#0000ff
size=2>There are many.</FONT></SPAN></DIV>
<DIV dir=ltr align=left><SPAN class=136124614-02052006><FONT color=#0000ff
size=2></FONT></SPAN> </DIV>
<DIV dir=ltr align=left><SPAN class=136124614-02052006><FONT color=#0000ff
size=2>Three recommendations:</FONT></SPAN></DIV>
<DIV dir=ltr align=left><SPAN class=136124614-02052006><FONT color=#0000ff
size=2></FONT></SPAN> </DIV>
<DIV dir=ltr align=left><SPAN class=136124614-02052006><FONT color=#0000ff
size=2> ABI has a very nice commercial offering for windows
called SeqScape (<A
href="https://products.appliedbiosystems.com/ab/en/US/adirect/ab?cmd=catNavigate2&catID=600582">https://products.appliedbiosystems.com/ab/en/US/adirect/ab?cmd=catNavigate2&catID=600582</A>).
</FONT></SPAN></DIV>
<DIV dir=ltr align=left><SPAN class=136124614-02052006><FONT color=#0000ff
size=2></FONT></SPAN> </DIV>
<DIV dir=ltr align=left><FONT size=2><FONT color=#0000ff><SPAN
class=136124614-02052006> Free/open-source is </SPAN><SPAN
class=136124614-02052006>Staden (<A
href="http://staden.sourceforge.net/">http://staden.sourceforge.net/</A>) which
has a variety of approaches to gene resequencing for mutation detection with
fairly recent development/improvements. Though it is cross-platform /
opensource, it optionally depends on components which are/were not available
windows - phred for base calling, phrap for assembly, so I suggest linux for
this.</SPAN></FONT></FONT></DIV>
<DIV dir=ltr align=left><SPAN class=136124614-02052006><FONT color=#0000ff
size=2></FONT></SPAN> </DIV>
<DIV dir=ltr align=left><SPAN class=136124614-02052006><FONT color=#0000ff
size=2> Also often used is a combo of Phred/Phrap/consed. see
PolyPhred: </FONT><A href="http://droog.mbt.washington.edu/PolyPhred.html"><FONT
size=2>http://droog.mbt.washington.edu/PolyPhred.html</FONT></A></SPAN></DIV>
<DIV dir=ltr align=left><SPAN class=136124614-02052006><FONT color=#0000ff
size=2></FONT></SPAN> </DIV>
<DIV dir=ltr align=left><SPAN class=136124614-02052006><FONT color=#0000ff
size=2>Good luck,</FONT></SPAN></DIV>
<DIV dir=ltr align=left><SPAN class=136124614-02052006><!-- Converted from text/plain format -->
<P><FONT color=#0000ff size=2>Malcolm Cook<BR>Stowers Institute for Medical
Research </FONT></SPAN></P></DIV>
<DIV dir=ltr align=left><SPAN class=136124614-02052006><FONT color=#0000ff
size=2></FONT></SPAN> </DIV><BR>
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<FONT face=Tahoma size=2><B>From:</B>
bio_bulletin_board-bounces+mec=stowers-institute.org@bioinformatics.org
[mailto:bio_bulletin_board-bounces+mec=stowers-institute.org@bioinformatics.org]
<B>On Behalf Of </B>Mhmoud Elhefnawi<BR><B>Sent:</B> Wednesday, April 26, 2006
8:40 AM<BR><B>To:</B> bio_bulletin_board@bioinformatics.org<BR><B>Subject:</B>
[BiO BB] software for sequence mutational analysis<BR></FONT><BR></DIV>
<DIV></DIV>
<DIV><FONT face=Arial size=2>Dear colleagues,</FONT></DIV>
<DIV><FONT face=Arial size=2></FONT> </DIV>
<DIV><FONT face=Arial size=2>I have some sequences closely related that
I want to perform mutationl analysis in an efficient way, locating mutations
locations, frequency of mutations, ...etc..</FONT></DIV>
<DIV><FONT face=Arial size=2>Is there some package that can help me with
that?</FONT></DIV>
<DIV><FONT face=Arial size=2>Thanks in advance for helping,</FONT></DIV>
<DIV><FONT face=Arial size=2>Mahmoud</FONT></DIV></BLOCKQUOTE></BODY></HTML>