<HTML><BODY style="word-wrap: break-word; -khtml-nbsp-mode: space; -khtml-line-break: after-white-space; ">RefSeq predictions get withdrawn, modified, and promoted to reviewed transcripts all the time in the course of curation and manual review, more than in the thousands ... In fact, the NM_ section (reviewed and better) is equally dynamic, only withdrawals are rare and most changes concern annotation ... <DIV><BR class="khtml-block-placeholder"></DIV><DIV>Which reminds me: how many times has the 'final' human genome been published now?</DIV><DIV> <BR><DIV><DIV>On Jun 6, 2006, at 11:53 AM, Michael Muratet US-Huntsville wrote:</DIV><BR class="Apple-interchange-newline"><BLOCKQUOTE type="cite"> <DIV><FONT color="#000000" face="Arial" size="2">Greetings</FONT></DIV> <DIV><FONT face="Arial" size="2"></FONT> </DIV> <DIV><FONT face="Arial" size="2">I recently discovered that about 3000 Refseq accessions that were present in the 4/2005 release have been withdrawn. The ones I've looked at appear to be NCBI predictions using their gnomon tool and had 'XM_*' accessions. I'm concerned that a database that is supposed to be stable is so dynamic. I asked NCBI about it, but didn't get an explanation. Does anybody have any experience with such large scale withdrawls? Does anybody know why?</FONT></DIV> <DIV><FONT face="Arial" size="2"></FONT> </DIV> <DIV><FONT face="Arial" size="2">Thanks</FONT></DIV> <DIV><FONT face="Arial" size="2"></FONT> </DIV> <DIV><FONT face="Arial" size="2">Mike</FONT></DIV><DIV style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; ">_______________________________________________</DIV><DIV style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; ">Bioinformatics.Org general forum<SPAN class="Apple-converted-space"> </SPAN>-<SPAN class="Apple-converted-space"> </SPAN><A href="mailto:BiO_Bulletin_Board@bioinformatics.org">BiO_Bulletin_Board@bioinformatics.org</A></DIV><DIV style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; "><A href="https://bioinformatics.org/mailman/listinfo/bio_bulletin_board">https://bioinformatics.org/mailman/listinfo/bio_bulletin_board</A></DIV> </BLOCKQUOTE></DIV><BR><DIV> <SPAN class="Apple-style-span" style="border-collapse: separate; 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margin-right: 0px; margin-bottom: 0px; margin-left: 0px; ">-- </DIV></SPAN></SPAN></SPAN><DIV style=""><FONT class="Apple-style-span" face="Monaco" size="2"><SPAN class="Apple-style-span" style="font-size: 10px;; font-family: Monaco; "><SPAN class="Apple-style-span" style="font-family: Monaco; font-size: 10px; "><SPAN class="Apple-style-span" style="font-family: Monaco; font-size: 10px; "><SPAN class="Apple-style-span" style="font-family: Monaco; font-size: 10px; ">===========================================================</SPAN></SPAN></SPAN></SPAN></FONT></DIV><DIV style=""><FONT class="Apple-style-span" face="Monaco" size="2"><SPAN class="Apple-style-span" style="font-size: 10px;; font-family: Monaco; "><SPAN class="Apple-style-span" style="font-family: Monaco; font-size: 10px; "><SPAN class="Apple-style-span" style="font-family: Monaco; font-size: 10px; "><SPAN class="Apple-style-span" style="font-family: Monaco; font-size: 10px; ">: Hilmar Lapp -:- Durham, NC -:- hlapp at gmx dot net :</SPAN></SPAN></SPAN></SPAN></FONT></DIV><DIV style=""><FONT class="Apple-style-span" face="Monaco" size="2"><SPAN class="Apple-style-span" style="font-size: 10px;; 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