At 11:18 AM 27/8/2002 +0200, you wrote: >Hi Chris, > > > > > > > Wim, > > > > If you assume that the two blast target sets are non-overlapping, the > > only scores which need to be recalculated are the e- and p- values. > > Score and Bit Score are based soley on the alignment, substitution > > matrix, and gap costs, plus the K and lambda parameters. Those don't > > change with target set size. > > > > e-value = { m n 2^(bit_score) } > >Shouldn't this be: > > e-value = { m n 2^(-bit_score) } > >I think you forgot a minus. This is the equation found in the blast >tutorial. Hi Wim, May I know which blast tutorial are you referring to here? Lai L F