> > As far as management features you can't beat osx server. If you are using the cluster to run Smith-Waterman, BLAST and HMMer, the single host hardware accelerators are very easy to manage also. Basically, you install the cards, pop in a CDROM and the system is up and running with the performance of more than 500 CPUs for HMMer. And formatting a database just one time on one disk makes updating targets quite easy also. If you are running in-house analysis programs, this is probably not the way to go, but it might take the BLAST and HMM load off an existing cluster so you can run those codes over there though. I think hybrid cluster/hardware accelerator systems could be a really superb way to balance cost, IT overhead and applications. -Alan -- - Alan Kilian <alank(at)timelogic.com> Director of Bioinformatics, TimeLogic Corporation 763-449-7622