Hi, I run BLAST very confortably on my 600MHz iBook for teaching. I used instructions that are found here: http://www.tc.umn.edu/~cann0010/Bioperl_OSX_install.html Look for the BLAST section. I prefer to build my apps from source so these instructions were perfect. Cordially Sylvain =================================================================== Sylvain Foisy, Ph. D. Directeur - operations / Project Manager BioneQ - Reseau quebecois de bio-informatique U. de Montreal / Genome-Quebec Adresse postale: Departement de biochimie Pavillon principal 2900, boul. Édouard-Montpetit Montréal (Québec) H3T 1J4 Tel: (514) 343-6111 x.4066 Courriel: sylvain.foisy at bioneq.qc.ca ===================================================================