Hi Ognen: I wasn't questioning whether or not having source is a good thing. I generally believe it is a good thing. The questions I am raising are subtle, and may be lost in the language. You raised one of my questions as a point, so I will try to be a bit more clear. First, I am wondering if people building their own tools to do their work or research are preferring open source (in the GPL sense) to commercial tools. Second, if the open source route is preferred, then is it because of the free as in libre or free as in beer reason. Third, if you prefer using commercial tools, may I ask why, and what tools. I am trying to get a sense for what those people who build the tools at end user or research sites prefer (unscientific, self selective poll that may still yield qualatative features I am interested in learning more about). What I am really getting after is whether or not there are real possibilities for building a business out of providing software and service for informatics computing. It seems to me that there are many business models that simply do not work here (ASP is a great example). I am wondering if being an independent bioinformatics software vendor is a workable scenario. Another way to put the question is, where is the value that a company or a group would be willing to pay for. Is it in the software side? The services? The implementation? The management? Where is the value, and are people willing to pay for it. This is a necessary question to ask if you are attempting to go to market with a product, or write a business plan, etc. Note: I think things like Bioperl, Ensembl, DAS, are excellent bits of work. They are tools to accomplish a particular set of analysis. Since they are available free (as in beer and as in Libre), offering a competing service which is neither (free nor libre) may be a poor business model. But working with them, and using them to build tools, or augmenting them might be interesting. I am hoping that people in industry and academe would comment with their thoughts on these issues, or raise some of their own. I think Chris Dagdigian and others would have opinions (as the neutral consultants). Joe On Thu, 2002-05-23 at 01:23, Ognen Duzlevski wrote: > If I never had the clustalw source available I would have never made its > multithreaded version available for free either. I am no researcher in > the field but to me as a programmer these tools are that - tools, and > they should be there at no cost so that people can focus on the real > stuff - figuring out what that little piece of information means and > does. -- Joe Landman, email: landman at scientificappliance.com web : http://scientificappliance.com