The bug I reported before turns out to have a pretty simple resolution: gcc needs the "-mieee" flag on this platform to correctly perform this bit of math on my particular platform. I added the flag to "platform/linux.ncbi.mk" and have created a set of binaries which can successfully align my sequences. Here's the rest of the story, for the interested: I took Joe and Iddo's advice, and made a little test program with my lethal values, which generate the underflow. [cdwan at alpha alpha]$ more test.c #include <math.h> #include <stdio.h> int main () { double Lambda, searchsp, score, logK; Lambda = 1.374063; score = 518; searchsp = 351649; logK = -0.341642; printf ("Hello world\n"); printf ("(-Lambda * score): %e\n", -Lambda * score); printf ("(-Lambda * score) + logK: %e\n", (-Lambda * score) + logK); printf ("exp(that): %e\n", exp((-Lambda * score) + logK)); printf ("searchsp * exp(that): %e\n", searchsp * exp((-Lambda * score) + logK )); printf("Goodbye world\n"); } Then I built it in a very minimal way: [cdwan at alpha alpha]$ /usr/local/bin/gcc -o test test.c -lm [cdwan at alpha alpha]$ ./test Hello world (-Lambda * score): -7.117646e+02 (-Lambda * score) + logK: -7.121063e+02 exp(that): 5.447206e-310 Floating exception (core dumped) It's interesting to me that the underflow happens on a multiplication step which should make the number in question *larger*. My guess is that somewhere in the guts of the multiplication routine for floating point numbers, they do something clever and fast which can result in a smaller number as an intermediate value. I'll skip all the incorrect compiler flags I tried, and go right to this: [cdwan at alpha alpha]$ /usr/local/bin/gcc -o test test.c -mieee -lm [cdwan at alpha alpha]$ ./test Hello world (-Lambda * score): -7.117646e+02 (-Lambda * score) + logK: -7.121063e+02 exp(that): 5.447206e-310 searchsp * exp(that): 1.915505e-304 Goodbye world I suggest that NCBI add the "-mieee" flag to their DEC makefiles. I also suggest that (as usual), everybody should check all their results, look for core files, and never ever trust a computer. Sometimes, "no hits" doesn't really mean "no hits." -Chris Dwan