[meltsim] Re: Meltsim - help

J.W. Bizzaro jeff at bioinformatics.org
Mon Aug 23 13:14:04 EDT 2004

Hi Chiu.

I was unaware of the "Poland service".  Then again, I haven't been 
working on denaturation problems recently.  Thanks for the link.

Drs. Blake and Delcourt may be aware of it.  Looking at the references, 
they are cited.  Richard Blake is the PI for the MeltSim project.

Considering the programs use the 1974 Poland algorithm, the 1977 
Fixman-Friere approximation, and the 1998 Blake-Delcourt parameters, 
they probably give similar results.  It would be interesting to see a 

Programatically, they use different languages: Pascal/Delphi for 
MeltSim, and FORTRAN 77 for the "Poland service".  I've been hoping to 
write a command-line version in C.

Regarding your problem inputting a text sequence, I'm happy to help. 
The sequence needs to be in plain text and unanotated.  If you're using 
a FASTA file, you need to remove the header.

(Please CC to <meltsim at bioinformatics.org>.)


Chiu Chau wrote:
> hi,
> I am using the Poland service from :
> http://www.biophys.uni-duesseldorf.de/local/POLAND/poland_help.html#Poland
> Is the Meltsim similar to this site since it use the same paper ?
> I have downloaded it and have some trouble input the seq. as text - 
> Can you give me some advice?
> Thanks
> Chiu Chau
> 35 Technology Drive, 
> Warren, NJ 07059.
> 908-226-8200x208
> fax : -0800
> cchau at BioArrayS.com 

J.W. Bizzaro
Bioinformatics Organization, Inc. (Bioinformatics.Org)
E-mail: jeff at bioinformatics.org
Phone:  +1 508 890 8600

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