Dear Richard Blake, I am using Meltsim in order to study the dependance of dna melting curves with respect to loop exponent and cooperativity parameter. I would like to know where they can be modified in the code. Many thanks and best regards, Taofiq Paraiso J.W. Bizzaro wrote: > Hi Taofiq. > > Questions about the algorithm will be best answered by Richard Blake. > Please send your question to <meltsim at bioinformatics.org> asking him > specifically. > > Do you have Enrico Carlon's email address? > > Cheers. > Jeff > > Taofiq Paraiso wrote: > >> Hi Jeff, >> >> Finally my administrator could modify the code in order to run it >> under Linux. >> We don't have the user interface any more but this is not a problem. >> Now I would like to modify the loop exponent and cooperativity >> parameters, which are >> called alpha and sigma in the code respectively. >> I understood that the value of alpha was assumed to be 1.75 (alpha is >> not initialized in the code). >> The value of sigma is calculated according to initial and the final >> values of sigma, which seem >> to be in relation with the initial and final temperature. Could you >> confirm if I understood well? >> >> Best regards, Tao >> >> ps: I just received an email from Enrico Carlon, who told me that he >> has a C version of meltsim. > >