We are happy to announce the second 3Dsig meeting focusing on Structural Bioinformatics & Computational Biophysics: http://3dsig.weizmann.ac.il/ August 4-5 at Fortaleza, BRAZIL At Fortaleza, 3Dsig bridges between two major Computational Biology Conferences: the 20th celebration of the SwissProt database http://www.swissprot20.org/ and the ISMB annual meeting of the International Society of Computational Biology (ISCB) http://www.iscb.org/ismb2006/ . 3Dsig topics include: * Structure representation, Structure prediction, Structural genomics * Docking: protein-protein and protein-ligand interaction prediction * Structural databases and 3D datamining * Structure-based function prediction * Prediction, assignment and analysis of secondary structures and domains * Membrane protein structure prediction and analysis * The role of geometry and energetics in protein structure and function * Protein dynamics and simulation: folding, stability, interactions, conformational gating * Computer aided protein design * Structure-based drug design and pharmacophore analysis 3Dsig 06 follows on from the successful 2004 meeting: http://3dsig.weizmann.ac.il/3dsig/2004/3dsigbook.pdf We welcome sponsorships. Explore opportunities at: http://3dsig.weizmann.ac.il/2006/sponsors.html Looking forward your participation in 3Dsig, 3Dsig organizing and scientific committees http://3dsig.weizmann.ac.il 3dsig06 at weizmann.ac.il