I've been hard at work coding up the next release of my program. I'm releasing it as 1.0 because I think it's finally got a reasonable set of features. There are versions for MacOsx, Linux GTK, and Windows. http://bosco.infogami.com/rama The design of the program is to allow you to easily see the Ramachandran plot (phi-psi angles) and the chi angles of a protein structure. You can explore conformation changes (phi/psi/chi angles) easily with a mouse. In order to see how conformation changes affect the protein, Ive included real-time calculation of H-bonds, weak H-bonds and (now) steric clashes. This makes it easy to see why regions of the Ramachandran plot are forbidden, and why some sidechain chi angles are favoured. I've included, what I think, is a necessary set of navigating tools (sequence bar, z-slab-bar, and lots of visual cues). It's also the only program I know that deals properly with proline ring conformations. There is a 3-point-clamp function, that (1) explores discrete solutions of a loop with fixed anchors and 3 hinge-residues, and (2) allows the exploration of the phi/psi angles of residues *inside* the clamp. The clamp prevents these phi/psi changes from disturbin the rest of the protein. You should be able to easily edit (cut/paste/insert) the sequence of the protein, and explore mutation, with a mouse. I've bent over backward to make sure new version uses native widgets (file open/save dialogs are standard!) and you can resize the window to your heart's content. So enjoy the program, and of course, email me for bug-reports, suggestions, anything. Bosco Ho Agard Lab, UCSF -- blog: inthestates.blogspot.com site: bosco.infogami.com