Konrad and Jay, I did some searching for applications that might be helpful for us to take a look at. Below are links to sites about algorithms that may be incorporated into TULIP and some projects that might parallel TULIP to some extent: The following four sites have GNU GPL licensed tools. If the core distribution of TULIP is to be all GPL, we need to look for tools that are also GPL. Software from the Eddy Lab http://www.genetics.wustl.edu/eddy/software/ The Sanger Centre : Dynamite http://www.sanger.ac.uk/Software/Dynamite/ SCRate http://www.mrc-lmb.cam.ac.uk:80/genomes/jong/SC_rate.html The Sanger Centre : Wise2 http://www.sanger.ac.uk/Software/Wise2/ The following are tools that are not GPL, but they are free, and the source code is available. So, the authors may be willing to make it GPL. If not, we can put them in a separate distribution. FETCH http://ind5.mrc-lmb.cam.ac.uk/fetch_home.html The Babel Home Page http://mercury.aichem.arizona.edu/babel.html Cn3D Home Page http://www.ncbi.nlm.nih.gov/Structure/cn3d.html Democritos Home Page http://www.seqnet.dl.ac.uk/CBMT/democ/HOME.html The Sanger Centre : Dotter [not GPL???] http://www.sanger.ac.uk/Software/Dotter/ NJplot http://pbil.univ-lyon1.fr/software/njplot.html tacg Version 2 - Documentation http://hornet.bio.uci.edu/~hjm/projects/tacg/tacg2.main.html The following are some projects that provide rather large packages for DNA and protein analyses. They may not be directly competing with TULIP, but they may give us some ideas. FASTA ftp://ftp.virginia.edu/pub/fasta/ Geanfammer home page : genome analysis and protein family maker http://www.mrc-lmb.cam.ac.uk/genomes/geanfammer.html SEALS Home Page http://www.ncbi.nlm.nih.gov/Walker/SEALS/index.html SeqPUP http://iubio.bio.indiana.edu/IUBio-Software+Data/molbio/seqpup/ The following are some Java-based packages, tools, and links to tools. Many bioinformaticists believe Java is _the_ language for the job, but others (as myself) tend to disagree. The advantages TULIP has over Java are that the compute-intensive stuff can be compiled, making TULIP much faster, and TULIP will be language independent (see next e-mail). Base4 Java Bioinformatics Links http://telomere.base4.com/html/java_list.html Javascript, Java and CORBA http://bioinformatics.weizmann.ac.il/comp/java_info.html Java-based Molecular Biology Work Bench http://www.embl-heidelberg.de/~toldo/JaMBW.html Neomorphic Software, Inc.'s Java Demos http://www.neomorphic.com/demo/ bioWidget Consortium http://www.biowidgets.org/ BioObjects: CORBA in Bioinformatics http://sunny.ebi.ac.uk/BioObjects/ CBIL bioWidgets for Java(tm) http://www.cbil.upenn.edu/bioWidgets/ AppLab Homepage http://industry.ebi.ac.uk/applab/ So far, I have found _no_large_bioinformatics_package_with_GNU_GPL_code_! Jeff -- J.W. Bizzaro Phone: 617-552-3905 Boston College mailto:bizzaro at bc.edu Department of Chemistry http://www.uml.edu/Dept/Chem/Bizzaro/ --