I just stumbled across this program: MUST, Management Utilities for Sequences and Trees. Information can be found in the article: H. Phillippe. 1993. Must, a computer package of Management Utilities for Sequences and Trees. Nucleic Acids Research. 21(22): 5264-5272. Sadly, no URL/ftp info is given. Distribution is either by acquiring a copy of the s/w from somebody who already has it, or by sending $100 to the author for a set of diskettes. Given the date, this does not surprise me, but I cannot find information on new versions. It was written in MS C 5.1, for Dos 3.x and higher (*shudder*). A unix version was in the design process at the time of publication. Regardless, the flowchart portraying data management in the document might provide some food for thought. Briefly, this is a phylogenetically oriented set of programs for data management and display, intended to be complementary to Phylip, Paup, hennig86 and clustalw. It allows uploading of new sequences, storing of aligned sequences (including multiple files), with correct formatting for input into phylogenetic analysis programs. Another description can be found at http://www.no.embnet.org/phylogeny.html 1993 contact info for the author is as follows: Herve Phillippe Laboratoire de Biologie Cellulaire, URA CNRS 1134 D, Batiment 444 Universite Paris-Sud 91405, Orsay Cedex, France -------------------------- J. Steinbachs, PhD Computational Biologist Dept of Botany The Field Museum Chicago, IL 60605-2496 office: 312-665-7810 fax: 312-665-7158 http://cb.fmnh.org --------------------------