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<p>I have completed 2 new tutorials:</p>
<p><a class="moz-txt-link-freetext" href="http://proteopedia.org/w/SARS-CoV-2_spike_protein_priming_by_furin">http://proteopedia.org/w/SARS-CoV-2_spike_protein_priming_by_furin</a></p>
<p><a class="moz-txt-link-freetext" href="http://proteopedia.org/w/SARS-CoV-2_spike_protein_fusion_transformation">http://proteopedia.org/w/SARS-CoV-2_spike_protein_fusion_transformation</a></p>
<p>Each includes interactive morph animations, and downloadable
Powerpoint-ready animations. These are based on recent <a
moz-do-not-send="true"
href="http://proteopedia.org/wiki/index.php/Cryo-EM">cryo-EM
structures</a> of multiple conformations.</p>
<p>A protease (typically furin, ample in the lungs) clips spike
protein, inducing the extension of a receptor-binding surface to
engage the ACE2 receptor on the host cell.<br>
</p>
<p>The mechanism of membrane fusion, which deposits the viral RNA
inside the host cell initiating infection, appears similar to that
of influenza hemagglutinin. The spike protein "spears" the host
cell membrane, capturing it with a "fusion peptide", and pulls the
virus membrane very close. Fusion has been seen in molecular
dynamics simulations (see Figure 2 in the fusion link). Spike
protein has a cavity that is the target of drug screening (see
Figure 4 in the fusion link). A cute graphical abstract shows a
3-legged folding stool as an analogy to spike protein, with the
drug-target cavity between its legs (see Figure 3 in the fusion
link).</p>
<p>For those developing educational tutorials, consider listing them
at <a class="moz-txt-link-freetext" href="http://Merlot.Org">http://Merlot.Org</a>, a well- and long-established catalog of
educational resources. See for example what I've listed there:</p>
<p><a
href="https://www.merlot.org/merlot/materials.htm?userId=14545&fromAdvancedSearch=true&sort.property=dateCreated">https://www.merlot.org/merlot/materials.htm?userId=14545&fromAdvancedSearch=true&sort.property=dateCreated</a></p>
<p>-Eric<br>
</p>
<div class="moz-signature"><br>
Eric Martz, Professor Emeritus, Dept Microbiology (he/him/his)
<br>
U Mass, Amherst -- <a href="http://Martz.MolviZ.Org">Martz.MolviZ.Org</a>
<ul>
<li>
Guided Exploration of Macromolecules: <a
href="http://firstglance.jmol.Org">FirstGlance.Jmol.Org</a>
</li>
<li>
Protein 3D Structure Wiki: <a href="http://proteopedia.Org">Proteopedia.Org</a>
</li>
<li>
Top Five 3D MolVis Tools: <a href="http://top5.MolviZ.Org">Top5.MolviZ.Org</a>
</li>
<li>
Education: Biochem in 3D at <a href="http://MolviZ.Org">MolviZ.Org</a>
</li>
<li>
Find Functional Patches in Proteins: <a
href="http://consurf.tau.ac.il">ConSurf</a>
</li>
<li>
Atlas of Macromolecules: <a href="http://atlas.MolviZ.Org">Atlas.MolviZ.Org</a>
</li>
<li>
Interactive Molecules in Architectural Spaces: <a
href="http://molecularplayground.Org">MolecularPlayground.Org</a>
</li>
<li>
Workshops: <a href="http://workshops.MolviZ.Org">Workshops.MolviZ.Org</a>
</li>
</ul>
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