Dear All: Doest anyone know a program that can first load an alignment (like structural alignment) and freeze this alignment , then add other sequences to this alignment? Cheers xueping ________________________________________________________________________ BT Yahoo! Broadband - Save £80 when you order online today. Hurry! Offer ends 21st December 2003. The way the internet was meant to be. http://uk.rd.yahoo.com/evt=21064/*http://btyahoo.yahoo.co.uk