<quote who="Dan Bolser"> > Hi, > > When defining domains based on sequence searching, do you find the 'dom-in-dom' > type situations which are seen with structural domains? > > For example at the chain level > > --/---A-part1---/----------B---------/----A-part2----/--- > > > which forms two globular domains at the structural level. > > I guess HMM can detect this, in addition to the situation > > --/----------A-alone-----------/--- > > > Is it a part of Pfam or any other sequence based domain definition? > > Cheers, > Dan.