Goel, Manisha wrote > Is there any ready source of getting the HMM profile for SCOP domain > families ? Yes, that is the SUPERFAM family of HMM models. http://supfam.mrc-lmb.cam.ac.uk/SUPERFAMILY/ (or http://supfam.org ) ------------------------------------------------------------ Kevin Karplus karplus at soe.ucsc.edu http://www.soe.ucsc.edu/~karplus life member (LAB, Adventure Cycling, American Youth Hostels) Effective Cycling Instructor #218-ck (lapsed) Senior member, IEEE Board of Directors, ISCB (starting Jan 2005) Professor of Biomolecular Engineering, University of California, Santa Cruz Undergraduate and Graduate Director, Bioinformatics Affiliations for identification only.