[ssml] Multiple sequence alignment

[Kevin Karplus]

I know of no way to evaluate the statistical significance of a
multiple alignment.  I'm not even sure that the phrase has a
mathematically definable meaning.

What do you *mean* by the "significance of a multiple sequence
alignment"?

Once we have established that, then we can look for a way to compute
(or approximate) it efficiently.

------------------------------------------------------------
Kevin Karplus 	karplus at soe.ucsc.edu	http://www.soe.ucsc.edu/~karplus
Professor of Biomolecular Engineering, University of California, Santa Cruz
Undergraduate and Graduate Director, Bioinformatics
(Senior member, IEEE)	(Board of Directors, ISCB)
Affiliations for identification only.