[ssml] Multiple sequence alignment

Kevin Karplus karplus at soe.ucsc.edu
Mon Aug 1 02:15:49 EDT 2005

I know of no way to evaluate the statistical significance of a
multiple alignment.  I'm not even sure that the phrase has a
mathematically definable meaning.

What do you *mean* by the "significance of a multiple sequence

Once we have established that, then we can look for a way to compute
(or approximate) it efficiently.

Kevin Karplus 	karplus at soe.ucsc.edu	http://www.soe.ucsc.edu/~karplus
Professor of Biomolecular Engineering, University of California, Santa Cruz
Undergraduate and Graduate Director, Bioinformatics
(Senior member, IEEE)	(Board of Directors, ISCB)
Affiliations for identification only.

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