Hello, I'm looking for a (profile-based) search method with which I could look for matches to a noncoding region of approx. 150 basepairs; I've already got the region for about 10 species; homology was established by proximity to a gene locus. Discontiguous Mega-Blast is not sensitive enough. I'd like to search the standard NCBI databases (at least NR & EST, optimally GSS, HTGS, WSS as well). Any hints? Could the problem be framed as a search for a very long transcription factor binding site, using the 10 sequences I have to construct the position weight matrix? If so, where could I search? I'm grateful for any help Georg Fuellen