I've been having trouble with blastpgp (the program that is the core of psi-blast) crashing on my cluster of x86_64 machines. The crash is not consistent---rerunning the same jobs can cause everything to complete fine, but is frequent enough to be a serious problem (2/3 of the jobs in a recent run crashed---on rerunning about 1/3 of the previously crashed ones completed ok). About the only symptom I'm seeing besides the crashes is [blastpgp] WARNING: [000.000] Failed to access string index ISAM Error code is -5 but that isn't even coming from the times that blastpgp is crashing! The same jobs run on older 32-bit machines do not seem to crash. I'm running fairly recent (Mar 2007?) of the software. Anyone have any suggestions? ------------------------------------------------------------ Kevin Karplus karplus at soe.ucsc.edu http://www.soe.ucsc.edu/~karplus Professor of Biomolecular Engineering, University of California, Santa Cruz Undergraduate and Graduate Director, Bioinformatics (Senior member, IEEE) (Board of Directors & Chair of Education Committee, ISCB) life member (LAB, Adventure Cycling, American Youth Hostels) Effective Cycling Instructor #218-ck (lapsed) Affiliations for identification only.