npde-package {npde}R Documentation

Normalised prediction distribution errors for nonlinear mixed-effect models

Description

Routines to compute normalised prediction distribution errors, a metric designed to evaluate non-linear mixed effect models such as those used in pharmacokinetics and pharmacodynamics

Details

Package: npde
Type: Package
Version: 1.0
Date: 2007-01-20
License: GPL version 2 or later

See the documentation for npde or autonpde for details

Author(s)

Emmanuelle Comets, Karl Brendel and France Mentré

Maintainer: Emmanuelle Comets <emmanuelle.comets@bichat.inserm.fr>

References

K. Brendel, E. Comets, C. Laffont, C. Laveille, and F. MentrĂ©. Metrics for external model evaluation with an application to the population pharmacokinetics of gliclazide. Pharmaceutical Research, 23:2036–49, 2006.

Examples

data(theopp)
data(simtheopp)

# Calling autonpde with dataframes

x<-autonpde(theopp,simtheopp,1,3,4,boolsave=FALSE)
x$npde

# Calling autonpde with names of files to be read from disk

write.table(theopp,"theopp.tab",quote=FALSE,row.names=FALSE)
write.table(simtheopp,"simtheopp.tab",quote=FALSE,row.names=FALSE)
x<-autonpde(namobs="theopp.tab", namsim="simtheopp.tab", iid = 1,
ix = 3, iy = 4, boolsave = FALSE)

x$npde


[Package npde version 1.2 Index]