PredictBias

		>ALARACEMASE#Alanine racemase signature.

		          Length = 356

		

		 Score = 28.6 bits (64), Expect = 0.042

		 Identities = 18/110 (16%), Positives = 37/110 (33%), Gaps = 34/110 (30%)

		

		Query: 83  LNRLNAGVLPEASLQAIYREIISCSFFLEGGLTIAYLGPKGTWSH----------QAALK 132

		           +NRL  G  P+  +  +++++ + +           +G     SH            A+ 

		Sbjct: 128 MNRL--GFQPD-RVLTVWQQLRAMAN----------VGEMTLMSHFAEAEHPDGISGAMA 174

		

		Query: 133 QFGKSCELIPCQ----------SFKDV-FDMVDRGKAQYGVVPVENSSEG 171

		           +  ++ E + C+             +  FD V  G   YG  P     + 

		Sbjct: 175 RIEQAAEGLECRRSLSNSAATLWHPEAHFDWVRPGIILYGASPSGQWRDI 224

		

		

		>adhesinb#Adhesin B signature.

		          Length = 310

		

		 Score =  186 bits (474), Expect = 2e-59

		 Identities = 81/317 (25%), Positives = 144/317 (45%), Gaps = 27/317 (8%)

		

		Query: 4   RILIP-FLCLLGLF-CSLQAQDAPV----LKIAALHPVLGDMARAIGGSRVQVADLLRPN 57

		           R L+   L  +GL  CS Q          L + A + ++ D+ + I G ++ +  ++   

		Sbjct: 5   RFLVLLLLAFVGLAACSSQKSSTETGSSKLNVVATNSIIADITKNIAGDKINLHSIVPVG 64

		

		Query: 58  GNLHSFEPSPQDIAAAGRARLVLASGKNLE----PYLPKLKDAL--GGSAQILDLGASVP 111

		            + H +EP P+D+    +A L+  +G NLE     +  KL +      +     +   V 

		Sbjct: 65  QDPHEYEPLPEDVKKTSQADLIFYNGINLETGGNAWFTKLVENAKKKENKDYYAVSEGVD 124

		

		Query: 112 DVPVEEDTADHDHEHDGDCCAHGPNDPHWWHTPANMKRAARTLAATLTRLDPAHEQDYKA 171

		            + +E        +   D        PH W    N    A+ +A  L+  DPA+++ Y+ 

		Sbjct: 125 VIYLEG----QSEKGKED--------PHAWLNLENGIIYAQNIAKRLSEKDPANKETYEK 172

		

		Query: 172 GLSRWNRKMDQLSSWARKELADIPETDRVLVTGHAAMNHFCREFGFRSISIQGISREDEG 231

		            L  +  K+  L   A+++  +IP   +++VT      +F + +   S  I  I+ E+EG

		Sbjct: 173 NLKAYVEKLSALDKEAKEKFNNIPGEKKMIVTSEGCFKYFSKAYNVPSAYIWEINTEEEG 232

		

		Query: 232 NSAQLASTLKKLRSAGVKALFPEYSSNPKSLTEIAKSLNIPVARPINTDGLAPEGH---T 288

		              Q+ + ++KLR   V +LF E S + + +  ++K  NIP+   I TD +A +G    +

		Sbjct: 233 TPDQIKTLVEKLRKTKVPSLFVESSVDDRPMKTVSKDTNIPIYAKIFTDSVAEKGEEGDS 292

		

		Query: 289 FESMFKQNTGIIKEALS 305

		           + SM K N   I E LS

		Sbjct: 293 YYSMMKYNLEKIAEGLS 309

		

		

		>HTHFIS#FIS bacterial regulatory protein HTH signature.

		          Length = 484

		

		 Score =  468 bits (1207), Expect = e-165

		 Identities = 156/480 (32%), Positives = 248/480 (51%), Gaps = 46/480 (9%)

		

		Query: 1   MDKTRIIVVEDNIVYCEYICNMLAREGYDTVKAYHLSTAKKQLQQAADDDIVVSDLRLPD 60

		           M    I+V +D+      +   L+R GYD     + +T  + +  A D D+VV+D+ +PD

		Sbjct: 1   MTGATILVADDDAAIRTVLNQALSRAGYDVRITSNAATLWRWIA-AGDGDLVVTDVVMPD 59

		

		Query: 61  GDGIELLRWMRKEGKMQPFIIMTDYAEVHTAVESMKLGSIDYIPKKLIEDKLVPLIRTIQ 120

		            +  +LL  ++K     P ++M+      TA+++ + G+ DY+PK     +L+ +I    

		Sbjct: 60  ENAFDLLPRIKKARPDLPVLVMSAQNTFMTAIKASEKGAYDYLPKPFDLTELIGIIGRAL 119

		

		Query: 121 KERQAGLNRIPVFAREG-------SAFQKIMHRIKLVATTDMSVMIFGENGTGKEHIAHH 173

		            E +   +++   +++G       +A Q+I   +  +  TD+++MI GE+GTGKE +A  

		Sbjct: 120 AEPKRRPSKLEDDSQDGMPLVGRSAAMQEIYRVLARLMQTDLTLMITGESGTGKELVARA 179

		

		Query: 174 LHEKSKRAGKPFVAVDCGSLSRELAPSAFFGHVKGAFTGADSTKKGYFHEAEGGTLFLDE 233

		           LH+  KR   PFVA++  ++ R+L  S  FGH KGAFTGA +   G F +AEGGTLFLDE

		Sbjct: 180 LHDYGKRRNGPFVAINMAAIPRDLIESELFGHEKGAFTGAQTRSTGRFEQAEGGTLFLDE 239

		

		Query: 234 VGNLALETQQMLLRAIQERRYRPVGDKSDRSFNVRIIATTNEDLEAAVSEKRFRQDLLYR 293

		           +G++ ++ Q  LLR +Q+  Y  VG ++    +VRI+A TN+DL+ ++++  FR+DL YR

		Sbjct: 240 IGDMPMDAQTRLLRVLQQGEYTTVGGRTPIRSDVRIVAATNKDLKQSINQGLFREDLYYR 299

		

		Query: 294 LRDFVITMPPLRDCQEDIMPLAEFFREIANKELECNASGFSSEARKALLTHAWPGNVREL 353

		           L    + +PPLRD  EDI  L   F + A KE   +   F  EA + +  H WPGNVREL

		Sbjct: 300 LNVVPLRLPPLRDRAEDIPDLVRHFVQQAEKE-GLDVKRFDQEALELMKAHPWPGNVREL 358

		

		Query: 354 RQKIMGAVLQAQEGVVTKEHLELAVPK--PTSPVSFALRNDAE----------------- 394

		              +        + V+T+E +E  +    P SP+  A                       

		Sbjct: 359 ENLVRRLTALYPQDVITREIIENELRSEIPDSPIEKAAARSGSLSISQAVEENMRQYFAS 418

		

		Query: 395 ------------------DKERIMRALKQTNGNRCAAAELLGISRTTLYGKLEEYGLKYK 436

		                             +   I+ AL  T GN+  AA+LLG++R TL  K+ E G+   

		Sbjct: 419 FGDALPPSGLYDRVLAEMEYPLILAALTATRGNQIKAADLLGLNRNTLRKKIRELGVSVY 478

		

		

		>RTXTOXIND#Gram-negative bacterial RTX secretion protein D

		           signature.

		          Length = 478

		

		 Score = 71.4 bits (175), Expect = 2e-15

		 Identities = 43/251 (17%), Positives = 92/251 (36%), Gaps = 45/251 (17%)

		

		Query: 88  VKAGQMLAEIDKLPVQLDVQRAEASKAQAIAGIARSKADIQ----QAKAKHQQARLDRER 143

		           V   ++L     +  Q    + +  K Q    + + +A+      +       +R+++ R

		Sbjct: 179 VSEEEVLRLTSLIKEQFSTWQNQ--KYQKELNLDKKRAERLTVLARINRYENLSRVEKSR 236

		

		Query: 144 --------AEKLGPGDAL--SKSSYDQYIADEETARANVAVAEASLQEAEASLKQAEAAL 193

		                    ++     A+   ++ Y + + +    ++ +   E+ +  A+   +      

		Sbjct: 237 LDDFSSLLHKQAIAKHAVLEQENKYVEAVNELRVYKSQLEQIESEILSAKEEYQLVTQLF 296

		

		Query: 194 KKEMR----------------------NLEYTTIKSPVDGVVVKRLVNIGQTVVSSMSAS 231

		           K E+                         + + I++PV   V +  V+    VV+  +A 

		Sbjct: 297 KNEILDKLRQTTDNIGLLTLELAKNEERQQASVIRAPVSVKVQQLKVHTEGGVVT--TAE 354

		

		Query: 232 SLFYIATDLSKLKIWAAVNEADIGSIRKGQEVLFTVDAFAGRKF---KGTVDKIRLDATM 288

		           +L  I  +   L++ A V   DIG I  GQ  +  V+AF   ++    G V  I LDA  

		Sbjct: 355 TLMVIVPEDDTLEVTALVQNKDIGFINVGQNAIIKVEAFPYTRYGYLVGKVKNINLDAIE 414

		

		Query: 289 --TSNVVTYIV 297

		                +V  ++

		Sbjct: 415 DQRLGLVFNVI 425

		

		

		

		 Score = 46.0 bits (109), Expect = 2e-07

		 Identities = 25/159 (15%), Positives = 53/159 (33%), Gaps = 17/159 (10%)

		

		Query: 60  VDVGAQVSGIIMEFGKD------LNGKV----VDYSSPVKAGQMLAEIDKLPVQLDVQRA 109

		           V++ A  +G +   G+        N  V    V     V+ G +L ++  L  + D  + 

		Sbjct: 80  VEIVATANGKLTHSGRSKEIKPIENSIVKEIIVKEGESVRKGDVLLKLTALGAEADTLKT 139

		

		Query: 110 EASKAQAIAGIARSKADIQQAKAKHQ-------QARLDRERAEKLGPGDALSKSSYDQYI 162

		           ++S  QA     R +   +  +           +        E++    +L K  +  + 

		Sbjct: 140 QSSLLQARLEQTRYQILSRSIELNKLPELKLPDEPYFQNVSEEEVLRLTSLIKEQFSTWQ 199

		

		Query: 163 ADEETARANVAVAEASLQEAEASLKQAEAALKKEMRNLE 201

		             +     N+    A      A + + E   + E   L+

		Sbjct: 200 NQKYQKELNLDKKRAERLTVLARINRYENLSRVEKSRLD 238

		

		

		>FLGMRINGFLIF#Flagellar M-ring protein signature.

		          Length = 559

		

		 Score = 29.2 bits (65), Expect = 0.035

		 Identities = 41/171 (23%), Positives = 63/171 (36%), Gaps = 26/171 (15%)

		

		Query: 225 RIPQLEAQVASSKNQLAVLLGTYNSRVELTLPKASVF---EKTPTVPVGLPSELLRRRPD 281

		               LE ++A +   L       ++RV L +PK S+F   +K+P+  V      +   P 

		Sbjct: 131 YQRALEGELARTIETLG---PVKSARVHLAMPKPSLFVREQKSPSASV-----TVTLEPG 182

		

		Query: 282 VIAAEADLHAAVANVGVAVADLYP----------RFSLTGSLSSRGGDFGQLFRENNNAW 331

		               E  + A V  V  AVA L P                + S R  +  QL   N+   

		Sbjct: 183 RALDEGQISAVVHLVSSAVAGLPPGNVTLVDQSGHLLTQSNTSGRDLNDAQLKFANDVES 242

		

		Query: 332 SLGG---NLLQPLFRGGALRATVRAQ--KAAAEQAAETYRKTLITAVSEVE 377

		            +      +L P+   G + A V AQ   A  EQ  E Y      + + + 

		Sbjct: 243 RIQRRIEAILSPIVGNGNVHAQVTAQLDFANKEQTEEHYSPNGDASKATLR 293

		

		

		>IGASERPTASE#IgA-specific serine endopeptidase (S6) signature.

		          Length = 1541

		

		 Score = 61.6 bits (149), Expect = 9e-12

		 Identities = 45/264 (17%), Positives = 86/264 (32%), Gaps = 15/264 (5%)

		

		Query: 15   KLRRRLVTAAPAAAPKVKFVSPAAE---GVEVVKPR--FLTPELQAKLAQEQEEAARRAA 69

		            + R + V       P        +      E+ +     + P   A  ++  E  A  + 

		Sbjct: 986  EKRNQTVDTTNITTPNNIQADVPSVPSNNEEIARVDEAPVPPPAPATPSETTETVAENSK 1045

		

		Query: 70   EQAEADRIAAEKAAAEQEAARIAAEKEAARIAAEQEAARI-KAEQEAAEAARIAAEKEAA 128

		            ++++      + A       R  A++  + + A  +   + ++  E  E       KE A

		Sbjct: 1046 QESKTVEKNEQDATETTAQNREVAKEAKSNVKANTQTNEVAQSGSETKETQTTET-KETA 1104

		

		Query: 129  RVAAEEERARL----AAELEKKEAASAPQPEPSVDAQIQDALAKVAEAQKALAEAQAAAL 184

		             V  +EE+A++      E+ K  +  +P+ E S   Q Q   A+  +    + E Q+   

		Sbjct: 1105 TVE-KEEKAKVETEKTQEVPKVTSQVSPKQEQSETVQPQAEPARENDPTVNIKEPQSQTN 1163

		

		Query: 185  AQAAGVAPAAVQTPEPSVPEPAPAGGAPKLKVFKTAAAPAAAEKSPVAAPESA-VPKLKV 243

		              A    PA   +     P            V +       A   P    ES+  PK + 

		Sbjct: 1164 TTADTEQPAKETSSNVEQPVTESTTVNTGNSVVENPENTTPATTQPTVNSESSNKPKNRH 1223

		

		Query: 244  LKS--PVGAAPASSVAPAAVPQPV 265

		             +S   V      +   +     V

		Sbjct: 1224 RRSVRSVPHNVEPATTSSNDRSTV 1247

		

		

		

		 Score = 53.1 bits (127), Expect = 4e-09

		 Identities = 42/296 (14%), Positives = 85/296 (28%), Gaps = 54/296 (18%)

		

		Query: 10   SPEPPKLRRRLVTAAPAAAPKVKFVSPAAEGVEVVKPRFLTPELQAKLAQEQEEAARRAA 69

		            +PE  K  + + T        ++   P+         R     +         E     A

		Sbjct: 982  NPEVEKRNQTVDTTNITTPNNIQADVPSVPSNNEEIARVDEAPVPPPAPATPSETTETVA 1041

		

		Query: 70   EQAEADRIAAEKAAAEQEAARIAAEKEAARIAAEQEAARIKAEQEAAEAARIAAEKEAAR 129

		            E ++  + +      EQ+A    A+    R  A++  + +KA  +  E A+  +E +  +

		Sbjct: 1042 ENSK--QESKTVEKNEQDATETTAQ---NREVAKEAKSNVKANTQTNEVAQSGSETKETQ 1096

		

		Query: 130  VAAEEERARLAAELEKKEAASAPQPEPSVDAQIQDALAKVAEAQKALAEAQAAALAQAAG 189

		                +E A +  E + K      Q  P V +Q+     K  +++    +A+ A       

		Sbjct: 1097 TTETKETATVEKEEKAKVETEKTQEVPKVTSQVS---PKQEQSETVQPQAEPA------- 1146

		

		Query: 190  VAPAAVQTPEPSVPEPAPAGGAPKLKVFKTAAAPAAAEKSPVAAPESAVPKLKVLKSPVG 249

		                          E  P                  ++ +  A  E              

		Sbjct: 1147 -------------RENDPT----------VNIKEPQSQTNTTADTEQP------------ 1171

		

		Query: 250  AAPASSVAPAAVPQPVVAEGVSPAAGAPPAGDGGIQPPAGTESARDMAASVDKSRS 305

		                +    + V QPV          +         P     +    +++  K+R 

		Sbjct: 1172 ----AKETSSNVEQPVTESTTVNTGNSVVENPENTTPATTQPTVNSESSNKPKNRH 1223

		

		

		>SECA#SecA protein signature.

		          Length = 901

		

		 Score = 31.4 bits (71), Expect = 8e-04

		 Identities = 13/42 (30%), Positives = 21/42 (50%), Gaps = 2/42 (4%)

		

		Query: 86  DLRRLAAVLEEIAELEAQTAKL--DTLRAEAEELRNRLTAKQ 125

		            LRR+  V+  I  +E +  KL  + L+ +  E R RL   +

		Sbjct: 17  TLRRMRKVVNIINAMEPEMEKLSDEELKGKTAEFRARLEKGE 58

		

		

		>NEISSPPORIN#Neisseria sp. porin signature.

		          Length = 348

		

		 Score = 28.8 bits (64), Expect = 0.040

		 Identities = 23/82 (28%), Positives = 35/82 (42%), Gaps = 18/82 (21%)

		

		Query: 244 VDTYRSGGKGGQNVNKVETAVRITHIPSGVIVACQNERSQLRNKEEAMNMLRAKLYQIEE 303

		           V TYRS       V+KVET   I    S +           + +E+  N L+A ++Q+E+

		Sbjct: 31  VQTYRSVEHTDGKVSKVETGSEIADFGSKI---------GFKGQEDLGNGLKA-VWQLEQ 80

		

		Query: 304 DKKQAEADRQYSEKGDIGWGNQ 325

		               A          + GWGN+

		Sbjct: 81  GASVA--------GTNTGWGNK 94

		

		

		>HTHFIS#FIS bacterial regulatory protein HTH signature.

		          Length = 484

		

		 Score = 27.5 bits (61), Expect = 0.024

		 Identities = 9/27 (33%), Positives = 15/27 (55%)

		

		Query: 117 EKFRNEAERHGLTVPEWASEALDALSS 143

		             F  +AE+ GL V  +  EAL+ + +

		Sbjct: 322 RHFVQQAEKEGLDVKRFDQEALELMKA 348

		

		

		>PF00577#Outer membrane usher protein FimD

		          Length = 878

		

		 Score = 35.2 bits (81), Expect = 0.001

		 Identities = 50/341 (14%), Positives = 95/341 (27%), Gaps = 65/341 (19%)

		

		Query: 253 SLSQPYVVTAEVDVPGGVKVSDTAGQYSPAETGSLGYDAPRMIVRGDKFPTGTAQWAARV 312

		             + PY     +   G  + S TAG+Y     G+   + PR       F   T       

		Sbjct: 357 IFTVPYSSVPLLQREGHTRYSITAGEYRS---GNAQQEKPR-------FFQSTLLHGLP- 405

		

		Query: 313 KRWAPALEDCAGLEVAASPKITSITPADAEHRGYSSAAVTHELTSGQINGKSARIKWGKV 372

		                 +    G ++A                 Y +         G +   S  +     

		Sbjct: 406 --AGWTIY--GGTQLA---------------DRYRAFNFGIGKNMGALGALSVDMTQANS 446

		

		Query: 373 RVDLRVRATDPPDTVKQYFPEYGGKSGTGDRWIGTLTFEVTTTNVGYASYRVDRAGTVES 432

		            +                 P+     G   R++   +   + TN+    YR   +G   +

		Sbjct: 447 TL-----------------PDDSQHDGQSVRFLYNKSLNESGTNIQLVGYRYSTSGYF-N 488

		

		Query: 433 VSDDGGSPGDDETSGSYDTSALYKNFLKSYYEATRALPYDGSATVHDDFDQVCGGRLSIT 492

		            +D   S  +     + D     K     YY            TV     +     L ++

		Sbjct: 489 FADTTYSRMNGYNIETQDGVIQVKPKFTDYYNLAYNKRGKLQLTVTQQLGR--TSTLYLS 546

		

		Query: 493 GGLKEWEAMRSVIQEISLDLKTGVSDVTV-------------GAPEQISLQDSIDRSRQL 539

		           G  + +    +V ++    L T   D+               G  + ++L  +I  S  L

		Sbjct: 547 GSHQTYWGTSNVDEQFQAGLNTAFEDINWTLSYSLTKNAWQKGRDQMLALNVNIPFSHWL 606

		

		Query: 540 AEALRRTAWADSSTSAGGGSSGGGSGSGGG--GSSGADDEV 578

		               +      S++ +      G   +  G  G+   D+ +

		Sbjct: 607 RSDSKSQWRHASASYSMSHDLNGRMTNLAGVYGTLLEDNNL 647

		

		

		>BINARYTOXINA#Clostridial binary toxin A signature.

		          Length = 454

		

		 Score = 33.9 bits (77), Expect = 0.002

		 Identities = 44/225 (19%), Positives = 74/225 (32%), Gaps = 70/225 (31%)

		

		Query: 344 GEVWAKA------SRLEKN---ALFSYTGNGYARINNDLRKGKS--------NAKAKQIA 386

		           G++W K       ++L  N    +  Y   GY  INN L             ++K   I 

		Sbjct: 261 GDLWGKENYSDWSNKLTPNELADVNDYMRGGYTAINNYLISNGPLNNPNPELDSKVNNIE 320

		

		Query: 387 KVIDRCKVPQDMVVFRGCGVY---------------KELKDAL--NWKGEEITDELVDML 429

		             +    +P +++V+R  G                  E  DA    W+G+ IT       

		Sbjct: 321 NALKLTPIPSNLIVYRRSGPQEFGLTLTSPEYDFNKIENIDAFKEKWEGKVIT------- 373

		

		Query: 430 NLSVVGNPLKDEGFMSAAVAEGKGFMNRPVLFRILLKKKTRAIYAEPFSRFGAGAGKDWD 489

		             + +   +     MSA       F  R ++ RI + K +   Y                

		Sbjct: 374 YPNFISTSIGSVN-MSA-------FAKRKIILRINIPKDSPGAYLSAIPG---------- 415

		

		Query: 490 GLSPQTYFSSEDEIIIQKGGTLKFLQFHNQNG----KLIIDCELI 530

		                  ++ E E+++  G   K  +  +       KLI+D  LI

		Sbjct: 416 -------YAGEYEVLLNHGSKFKINKVDSYKDGTVTKLILDATLI 453

		

		

		>PF05272#Virulence-associated E family protein

		          Length = 892

		

		 Score = 29.3 bits (65), Expect = 0.025

		 Identities = 12/28 (42%), Positives = 15/28 (53%), Gaps = 1/28 (3%)

		

		Query: 18  VIIYGPEGVGKSTLAAGL-PAPLFLDTE 44

		           V++ G  G+GKSTL   L     F DT 

		Sbjct: 599 VVLEGTGGIGKSTLINTLVGLDFFSDTH 626

		

		

		>SECBCHAPRONE#Bacterial protein-transport SecB chaperone protein

		           signature.

		          Length = 170

		

		 Score = 36.0 bits (83), Expect = 2e-05

		 Identities = 27/141 (19%), Positives = 62/141 (43%), Gaps = 16/141 (11%)

		

		Query: 15  FQLRAYYVSEFSIRTNKRFDNKKEPDLKFNSLKFELDFEELDSEKGAQKSEHLKGFNLWE 74

		            Q++  YV + S      F+    P +     + +L     D    A++       +L+E

		Sbjct: 20  LQIQRIYVKDVS------FEAPNLPHIFQQDWEPKLS---FDLSTEAKQVGD----DLYE 66

		

		Query: 75  VRLNVSMDEKKVEENNIPYSFFIALSGLFSFPQKNPTPKDDQLRFVRINGPSILYGFVRE 134

		           V LN+S++       ++ +   +  +G+F+        +      +    P++L+ + RE

		Sbjct: 67  VCLNISVETTMESSGDVAFICEVKQAGVFTISG---LEEMQMAHCLTSQCPNMLFPYARE 123

		

		Query: 135 IVNSFYDKGPYPSPVLPTISF 155

		           +V+S  ++G +P+  L  ++F

		Sbjct: 124 LVSSLVNRGTFPALNLSPVNF 144

		

		

		>HTHFIS#FIS bacterial regulatory protein HTH signature.

		          Length = 484

		

		 Score = 40.6 bits (95), Expect = 2e-05

		 Identities = 57/282 (20%), Positives = 91/282 (32%), Gaps = 80/282 (28%)

		

		Query: 279 RARLISPDKNKVTFKDVAGISEAKEEVWELVEFLRNPEKFRDLGATIPRGVLMVGAPGTG 338

		           + R    + +      + G S A +E++ ++                   +++ G  GTG

		Sbjct: 123 KRRPSKLEDDSQDGMPLVGRSAAMQEIYRVL----------ARLMQTDLTLMITGESGTG 172

		

		Query: 339 KTLLARAIAGES---NASFYS-----ISGSDFVEMFVGV------GASRVRD-MFEQA-K 382

		           K L+ARA+       N  F +     I          G       GA       FEQA  

		Sbjct: 173 KELVARALHDYGKRRNGPFVAINMAAIPRDLIESELFGHEKGAFTGAQTRSTGRFEQAEG 232

		

		Query: 383 RTAPSLIFIDEIDA-----------VGRQRGYGMGGGNDEREQTLNALLVEMDGFENNSN 431

		            T    +F+DEI             V +Q  Y   GG                     S+

		Sbjct: 233 GT----LFLDEIGDMPMDAQTRLLRVLQQGEYTTVGGRTPI----------------RSD 272

		

		Query: 432 VIVIAATNRADILDPALLRPGRFDRQ--------VVVNLPDVRGR--------EQILQVH 475

		           V ++AATN+ D+     +  G F R+        V + LP +R R           +Q  

		Sbjct: 273 VRIVAATNK-DL--KQSINQGLF-REDLYYRLNVVPLRLPPLRDRAEDIPDLVRHFVQQA 328

		

		Query: 476 ARKVKMAPGVSFERIARGTS-GFSG--AQLANLVNEAALLAA 514

		            ++         E +    +  + G   +L NLV     L  

		Sbjct: 329 EKEGLDVKRFDQEALELMKAHPWPGNVRELENLVRRLTALYP 370

		

		

		>PF05272#Virulence-associated E family protein

		          Length = 892

		

		 Score = 30.4 bits (68), Expect = 0.005

		 Identities = 14/42 (33%), Positives = 20/42 (47%), Gaps = 5/42 (11%)

		

		Query: 14  GKQWIFENYNRVFTSGIT-----ILKGYSGCGKTTLLKILAG 50

		           GK  +  +  RV   G       +L+G  G GK+TL+  L G

		Sbjct: 577 GKYILMGHVARVMEPGCKFDYSVVLEGTGGIGKSTLINTLVG 618

		

		

		>PF05272#Virulence-associated E family protein

		          Length = 892

		

		 Score = 34.3 bits (78), Expect = 0.004

		 Identities = 23/94 (24%), Positives = 33/94 (35%), Gaps = 18/94 (19%)

		

		Query: 418 VVHLNAYHALRCRFSA-----------------GVLDEEYHAIRTLSVEGVTKEFLRSGR 460

		              +N  H  R    A                 G   ++Y   R   ++ V K  L  G 

		Sbjct: 526 AADMNRVHPFRDWVKAQQWDEVPRLEKWLVHVLGKTPDDYKPRRLRYLQLVGKYIL-MGH 584

		

		Query: 461 VLDNIDLTVKRGEMVCILGPSGSGKSTLLSMLAG 494

		           V   ++   K    V + G  G GKSTL++ L G

		Sbjct: 585 VARVMEPGCKFDYSVVLEGTGGIGKSTLINTLVG 618

		

		

		>DHBDHDRGNASE#2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase

		           signature.

		          Length = 261

		

		 Score = 70.5 bits (172), Expect = 2e-16

		 Identities = 57/197 (28%), Positives = 91/197 (46%), Gaps = 9/197 (4%)

		

		Query: 1   MHTARLQYDRIIITGASSGFGEAFAGTLAPHTAELVLIARNEAALRQLAAALEKRHSGLH 60

		           M+   ++     ITGA+ G GEA A TLA   A +  +  N   L ++ ++L+      H

		Sbjct: 1   MNAKGIEGKIAFITGAAQGIGEAVARTLASQGAHIAAVDYNPEKLEKVVSSLKAE--ARH 58

		

		Query: 61  ASVLPCDLADEASLNMLISRLDSLPPGRTLLINNAG---AGDYGDFSDGRWEKIRFLLRL 117

		           A   P D+ D A+++ + +R++       +L+N AG    G     SD  WE       +

		Sbjct: 59  AEAFPADVRDSAAIDEITARIEREMGPIDILVNVAGVLRPGLIHSLSDEEWEAT---FSV 115

		

		Query: 118 NVESLTRLCHALVPSMK-RNGGDIINLSSLGALLPIPDFAVYAATKAYVSSLSEALRLEL 176

		           N   +     ++   M  R  G I+ + S  A +P    A YA++KA     ++ L LEL

		Sbjct: 116 NSTGVFNASRSVSKYMMDRRSGSIVTVGSNPAGVPRTSMAAYASSKAAAVMFTKCLGLEL 175

		

		Query: 177 REHGIRVLVVCPGPVST 193

		            E+ IR  +V PG   T

		Sbjct: 176 AEYNIRCNIVSPGSTET 192

		

		

		>PF05616#Neisseria meningitidis TspB protein

		          Length = 501

		

		 Score = 33.6 bits (76), Expect = 0.002

		 Identities = 18/47 (38%), Positives = 21/47 (44%), Gaps = 1/47 (2%)

		

		Query: 471 APKPPPAPKPESGGTAETPADKRKKEEAPGNKPAPAPAPPASPQTAP 517

		           A  P   P PE    AE PA+     E PG +P P P P  +P   P

		Sbjct: 320 AEAPNAQPLPEVS-PAENPANNPAPNENPGTRPNPEPDPDLNPDANP 365

		

		

		

		 Score = 31.3 bits (70), Expect = 0.012

		 Identities = 16/41 (39%), Positives = 23/41 (56%), Gaps = 1/41 (2%)

		

		Query: 478 PKPE-SGGTAETPADKRKKEEAPGNKPAPAPAPPASPQTAP 517

		           P+P+ + G+AE P  +   E +P   PA  PAP  +P T P

		Sbjct: 311 PRPDLTPGSAEAPNAQPLPEVSPAENPANNPAPNENPGTRP 351

		

		

		>HTHFIS#FIS bacterial regulatory protein HTH signature.

		          Length = 484

		

		 Score =  401 bits (1033), Expect = e-138

		 Identities = 132/364 (36%), Positives = 194/364 (53%), Gaps = 30/364 (8%)

		

		Query: 172 EERAALVAENEKLRELLTTN--PGELIGNCSTMLQVYEQIRQVAPSDATVLIRGSSGTGK 229

		               AL     +  +L   +     L+G  + M ++Y  + ++  +D T++I G SGTGK

		Sbjct: 114 IIGRALAEPKRRPSKLEDDSQDGMPLVGRSAAMQEIYRVLARLMQTDLTLMITGESGTGK 173

		

		Query: 230 ELVARAVVNLSGRKDKPLVTLNCAAMPENLLESELFGHEKGSFTGATSRRIGRAEAADGG 289

		           ELVARA+ +   R++ P V +N AA+P +L+ESELFGHEKG+FTGA +R  GR E A+GG

		Sbjct: 174 ELVARALHDYGKRRNGPFVAINMAAIPRDLIESELFGHEKGAFTGAQTRSTGRFEQAEGG 233

		

		Query: 290 TLFLDEIGDLSLQMQVKLLRFLQEKTFSRVGSNRELHADVRFIAATSRNLEELMAASKFR 349

		           TLFLDEIGD+ +  Q +LLR LQ+  ++ VG    + +DVR +AAT+++L++ +    FR

		Sbjct: 234 TLFLDEIGDMPMDAQTRLLRVLQQGEYTTVGGRTPIRSDVRIVAATNKDLKQSINQGLFR 293

		

		Query: 350 EDLYYRLNIFPIVMPDLSKRKGDVMLLAEHFLSKFNLKYGKDIKRLSTPAINMLMAYHWP 409

		           EDLYYRLN+ P+ +P L  R  D+  L  HF+ +   K G D+KR    A+ ++ A+ WP

		Sbjct: 294 EDLYYRLNVVPLRLPPLRDRAEDIPDLVRHFVQQAE-KEGLDVKRFDQEALELMKAHPWP 352

		

		Query: 410 GNVRELENCMERAVITAQDDCIYGYNLPASLQMPSHDVPYSRDG---------------- 453

		           GNVRELEN + R       D I    +   L+    D P  +                  

		Sbjct: 353 GNVRELENLVRRLTALYPQDVITREIIENELRSEIPDSPIEKAAARSGSLSISQAVEENM 412

		

		Query: 454 -----------EAPADLPTMVDSFERELIVAALKRSPGNMSAAARELGISPRVLHYKMHR 502

		                              ++   E  LI+AAL  + GN   AA  LG++   L  K+  

		Sbjct: 413 RQYFASFGDALPPSGLYDRVLAEMEYPLILAALTATRGNQIKAADLLGLNRNTLRKKIRE 472

		

		Query: 503 LGLQ 506

		           LG+ 

		Sbjct: 473 LGVS 476

		

		

		>HTHTETR#TetR bacterial regulatory protein HTH signature.

		          Length = 215

		

		 Score = 69.3 bits (169), Expect = 1e-16

		 Identities = 27/148 (18%), Positives = 60/148 (40%), Gaps = 9/148 (6%)

		

		Query: 6   KSQSDRSAETSGKILRAAQKLFALRGFNGVTMRAVASEAGVNLASIVYYFENKEGLYLAV 65

		           +     + ET   IL  A +LF+ +G +  ++  +A  AGV   +I ++F++K  L+  +

		Sbjct: 3   RKTKQEAQETRQHILDVALRLFSQQGVSSTSLGEIAKAAGVTRGAIYWHFKDKSDLFSEI 62

		

		Query: 66  YRQYAEPLMKARMKMLKEADLHPSLRAYARAFIEPAFRLFLDESLGGPDHVRLLWRLP-Q 124

		           +      +    +++  +A       +  R  +       + E     +  RLL  +   

		Sbjct: 63  WELSESNI--GELELEYQAKFPGDPLSVLREILIHVLESTVTE-----ERRRLLMEIIFH 115

		

		Query: 125 EPEYLG-RKIYDEFYAPSIQEMIARIRR 151

		           + E++G   +  +       E   RI +

		Sbjct: 116 KCEFVGEMAVVQQAQRNLCLESYDRIEQ 143

		

		

		>TONBPROTEIN#Gram-negative bacterial tonB protein signature.

		          Length = 239

		

		 Score = 37.3 bits (86), Expect = 5e-05

		 Identities = 14/60 (23%), Positives = 19/60 (31%), Gaps = 1/60 (1%)

		

		Query: 1   MDIPLPPLEAPPLPPPMDIPLPPLPEVPLPPPVDIPLPPPAGIPPLPPLSGRPTVPRQKK 60

		            D+  P    PP  P ++    P P    P    + +  P   P   P      V  Q K

		Sbjct: 53  ADLEPPQAVQPPPEPVVEPEPEPEPIPEPPKEAPVVIEKPKPKPKPKP-KPVKKVQEQPK 111

		

		

		

		 Score = 30.0 bits (67), Expect = 0.010

		 Identities = 15/52 (28%), Positives = 19/52 (36%), Gaps = 1/52 (1%)

		

		Query: 10  APPLPPPMDIPLPPLPEV-PLPPPVDIPLPPPAGIPPLPPLSGRPTVPRQKK 60

		              L PP  +  PP P V P P P  IP PP      +     +P    +  

		Sbjct: 52  PADLEPPQAVQPPPEPVVEPEPEPEPIPEPPKEAPVVIEKPKPKPKPKPKPV 103

		

		

		>60KDINNERMP#60kDa inner membrane protein signature.

		          Length = 548

		

		 Score = 28.4 bits (63), Expect = 0.041

		 Identities = 11/36 (30%), Positives = 18/36 (50%)

		

		Query: 108 RRYYLSGEKSYEKAKGENPKPATITFTDKGGYCYYK 143

		           R  Y   + +Y  A+G+N     +T+TD  G  + K

		Sbjct: 128 RPLYNVEKDAYVLAEGQNELQVPMTYTDAAGNTFTK 163

		

		

		>cdtoxinb#Cytolethal distending toxin B signature.

		          Length = 269

		

		 Score = 31.1 bits (70), Expect = 0.002

		 Identities = 26/123 (21%), Positives = 44/123 (35%), Gaps = 13/123 (10%)

		

		Query: 63  YAKAIDYSGGSYGVGILSREKPLSVKRIPLPGREEARVLLMAEF-RDYWFCVTHLSLTKE 121

		           Y  A+D  GG   + ++S  +   V  +  P R+  R LL      D +F    +++   

		Sbjct: 103 YFSAVDALGGRVNLALVSNRRADEVFVLS-PVRQGGRPLLGIRIGNDAFFTAHAIAMRNN 161

		

		Query: 122 DSSASIDMIAALAAKCSKP------FFIAGDFNLTPDS-----EPITRMKKYFILLSDPA 170

		           D+ A ++ +         P      + I GDFN  P           R     I  +   

		Sbjct: 162 DAPALVEEVYNFFRDSRDPVHQALNWMILGDFNREPADLEMNLTVPVRRASEIISPAAAT 221

		

		Query: 171 QKT 173

		           Q +

		Sbjct: 222 QTS 224

		

		

		>PF06580#Sensor histidine kinase

		          Length = 349

		

		 Score = 26.8 bits (59), Expect = 0.017

		 Identities = 17/86 (19%), Positives = 32/86 (37%), Gaps = 5/86 (5%)

		

		Query: 14  IGWPLGFKLSQTPGTGPGKFAACIACSVFSMVLSGFLLWLAQRNIPIGTAYAVW-----T 68

		           IGW +         +  G           ++ L G +L  A R+      +         

		Sbjct: 18  IGWGVYTLTGFGFASLYGSPKLHSMIFNIAISLMGLVLTHAYRSFIKRQGWLKLNMGQII 77

		

		Query: 69  GIGALGTFLVGILWFGDSSNIWRMLA 94

		                   ++G++WF  +++IWR+LA

		Sbjct: 78  LRVLPACVVIGMVWFVANTSIWRLLA 103

		

		

		>PRTACTNFAMLY#Pertactin virulence factor family signature.

		          Length = 910

		

		 Score = 37.3 bits (86), Expect = 3e-04

		 Identities = 63/226 (27%), Positives = 88/226 (38%), Gaps = 21/226 (9%)

		

		Query: 706 AGGLAVNS-LWSSASNAAALGGNVLSRLSVPRLTDRHARNLWGMGLGDFARQRSRGGVDG 764

		            GG+ + S LW + SNA      +  RL   RL    A   WG G     +  +R G   

		Sbjct: 616 TGGVGLASTLWYAESNA------LSKRLGELRLNP-DAGGAWGRGFAQRQQLDNRAG-RR 667

		

		Query: 765 YDYNGGGYSVGADSGMGGEGEGIWGIAFGQLCGHARS-RDFQGRNTQDTLMGSLYWGRLM 823

		           +D    G+ +GAD  +   G G W +  G L G+ R  R F G     T   S++ G   

		Sbjct: 668 FDQKVAGFELGADHAVAVAG-GRWHL--GGLAGYTRGDRGFTGDGGGHT--DSVHVGGYA 722

		

		Query: 824 EESNRACWIFKGSLTWAETRNNMTSRLGGAPASTGKWNNETWLAQAEVSRTADCAGGWRL 883

		                + +    +L  +   N+         A  GK+      A  E  R    A GW L

		Sbjct: 723 TYIADSGFYLDATLRASRLENDFKVAGSDGYAVKGKYRTHGVGASLEAGRRFTHADGWFL 782

		

		Query: 884 TPFVRMEFTHGRQDAFREQGGYG-RDFGG-AALKRLSIPVGLEIGR 927

		            P   +        A+R   G   RD GG + L RL    GLE+G+

		Sbjct: 783 EPQAELAVFRAGGGAYRAANGLRVRDEGGSSVLGRL----GLEVGK 824

		

		

		>ACRIFLAVINRP#Acriflavin resistance protein family signature.

		          Length = 1034

		

		 Score = 1097 bits (2839), Expect = 0.0

		 Identities = 519/1027 (50%), Positives = 715/1027 (69%), Gaps = 6/1027 (0%)

		

		Query: 1    MPDFFIRRPIFAWVVALLISLMGLLAIPSLPIAQYPDIAPPVITLRTTYPGASAQDTEEA 60

		            M +FFIRRPIFAWV+A+++ + G LAI  LP+AQYP IAPP +++   YPGA AQ  ++ 

		Sbjct: 1    MANFFIRRPIFAWVLAIILMMAGALAILQLPVAQYPTIAPPAVSVSANYPGADAQTVQDT 60

		

		Query: 61   VTAVIEKEINGAPGLMYMSATSSSDGTVEIAATFTQGTDPDIAAVEVQNRLKIVESRLPE 120

		            VT VIE+ +NG   LMYMS+TS S G+V I  TF  GTDPDIA V+VQN+L++    LP+

		Sbjct: 61   VTQVIEQNMNGIDNLMYMSSTSDSAGSVTITLTFQSGTDPDIAQVQVQNKLQLATPLLPQ 120

		

		Query: 121  SVRREGVFVEKSSNNIQAMISLSST-GSLNDTELGEWASARIIPELKRVKGVGRVELFGA 179

		             V+++G+ VEKSS++   +    S        ++ ++ ++ +   L R+ GVG V+LFGA

		Sbjct: 121  EVQQQGISVEKSSSSYLMVAGFVSDNPGTTQDDISDYVASNVKDTLSRLNGVGDVQLFGA 180

		

		Query: 180  ETSMRIWPDPEKLEALGLTPTDIVNAVAAQSERIIIGDIGGAAVPESAPINAGVVAEDAF 239

		            + +MRIW D + L    LTP D++N +  Q+++I  G +GG        +NA ++A+  F

		Sbjct: 181  QYAMRIWLDADLLNKYKLTPVDVINQLKVQNDQIAAGQLGGTPALPGQQLNASIIAQTRF 240

		

		Query: 240  RTPEEFASIALRTLSDGSSVKLGDVARVELGANSYAFFSRCNGQTATGMAIKMAPGSNAV 299

		            + PEEF  + LR  SDGS V+L DVARVELG  +Y   +R NG+ A G+ IK+A G+NA+

		Sbjct: 241  KNPEEFGKVTLRVNSDGSVVRLKDVARVELGGENYNVIARINGKPAAGLGIKLATGANAL 300

		

		Query: 300  ETMGLLKAKMDELSRDFPPGVSYQIPYETTHFVEISIRKVISTLLEAVLLVFLVMFLFLQ 359

		            +T   +KAK+ EL   FP G+    PY+TT FV++SI +V+ TL EA++LVFLVM+LFLQ

		Sbjct: 301  DTAKAIKAKLAELQPFFPQGMKVLYPYDTTPFVQLSIHEVVKTLFEAIMLVFLVMYLFLQ 360

		

		Query: 360  NFRATLIPTLVVPVALLGTFAVMWLSGFSINMLTMFGMVLSIGILVDDAIVVVENVERIM 419

		            N RATLIPT+ VPV LLGTFA++   G+SIN LTMFGMVL+IG+LVDDAIVVVENVER+M

		Sbjct: 361  NMRATLIPTIAVPVVLLGTFAILAAFGYSINTLTMFGMVLAIGLLVDDAIVVVENVERVM 420

		

		Query: 420  MEEGLDARRATVKAMKQIGGAIVGITAVLVAVFVPMAFFSGAVGNIYRQFAVTLIVSISF 479

		            ME+ L  + AT K+M QI GA+VGI  VL AVF+PMAFF G+ G IYRQF++T++ +++ 

		Sbjct: 421  MEDKLPPKEATEKSMSQIQGALVGIAMVLSAVFIPMAFFGGSTGAIYRQFSITIVSAMAL 480

		

		Query: 480  SAFLALSLTPALCAAMLKPSSVEHQE-KKGFFGWFNRTIHRSTDRYGRAVSGMIRRPVRS 538

		            S  +AL LTPALCA +LKP S EH E K GFFGWFN T   S + Y  +V  ++    R 

		Sbjct: 481  SVLVALILTPALCATLLKPVSAEHHENKGGFFGWFNTTFDHSVNHYTNSVGKILGSTGRY 540

		

		Query: 539  LFLYALIIAGAGYLYLTLPTSFLPEEDQGNFMAMVSLPAGTLQKETSVRLREVEDYLMRH 598

		            L +YALI+AG   L+L LP+SFLPEEDQG F+ M+ LPAG  Q+ T   L +V DY +++

		Sbjct: 541  LLIYALIVAGMVVLFLRLPSSFLPEEDQGVFLTMIQLPAGATQERTQKVLDQVTDYYLKN 600

		

		Query: 599  EP--VEHVYSVGGFSFMGSGTNMAMLFVGLKNWDERPGENSSVQAIIDRVNARFAGDGQM 656

		            E   VE V++V GFSF G   N  M FV LK W+ER G+ +S +A+I R           

		Sbjct: 601  EKANVESVFTVNGFSFSGQAQNAGMAFVSLKPWEERNGDENSAEAVIHRAKMELGKIRDG 660

		

		Query: 657  MVMALNMPALPELGNSSGFDFRLQDKGGLGYARMAEARDELLARANANP-NLAGVYFSGQ 715

		             V+  NMPA+ ELG ++GFDF L D+ GLG+  + +AR++LL  A  +P +L  V  +G 

		Sbjct: 661  FVIPFNMPAIVELGTATGFDFELIDQAGLGHDALTQARNQLLGMAAQHPASLVSVRPNGL 720

		

		Query: 716  ADTPRLHVSIDREKAFSMGVPIAEISNSLAVMFGSSYVGDFMHDSQVRRIMVQADGKSRL 775

		             DT +  + +D+EKA ++GV +++I+ +++   G +YV DF+   +V+++ VQAD K R+

		Sbjct: 721  EDTAQFKLEVDQEKAQALGVSLSDINQTISTALGGTYVNDFIDRGRVKKLYVQADAKFRM 780

		

		Query: 776  NGNDIEDLHVRNDQGKLLPLSSFVRLDWTAGPPQLTRYNNYPSFTINGSSAPGKSSGDAM 835

		               D++ L+VR+  G+++P S+F    W  G P+L RYN  PS  I G +APG SSGDAM

		Sbjct: 781  LPEDVDKLYVRSANGEMVPFSAFTTSHWVYGSPRLERYNGLPSMEIQGEAAPGTSSGDAM 840

		

		Query: 836  NALEQITASLPQGVGFEWTGQSYEEKLAGSQATLLFGLSILIVFLVLAALYESWSIPLAV 895

		              +E + + LP G+G++WTG SY+E+L+G+QA  L  +S ++VFL LAALYESWSIP++V

		Sbjct: 841  ALMENLASKLPAGIGYDWTGMSYQERLSGNQAPALVAISFVVVFLCLAALYESWSIPVSV 900

		

		Query: 896  ILVVPLGLLGALLAVFLRDMPNDIYFKVGLITTIGLSAKNAILIVEVAREFYR-EGMNAA 954

		            +LVVPLG++G LLA  L +  ND+YF VGL+TTIGLSAKNAILIVE A++    EG    

		Sbjct: 901  MLVVPLGIVGVLLAATLFNQKNDVYFMVGLLTTIGLSAKNAILIVEFAKDLMEKEGKGVV 960

		

		Query: 955  EAAVAAAKLRLRPILMTSLAFGAGVIPLAFAHGAAAGAQRAVGTGVLGGIITATLLAIFL 1014

		            EA + A ++RLRPILMTSLAF  GV+PLA ++GA +GAQ AVG GV+GG+++ATLLAIF 

		Sbjct: 961  EATLMAVRMRLRPILMTSLAFILGVLPLAISNGAGSGAQNAVGIGVMGGMVSATLLAIFF 1020

		

		Query: 1015 VPLFFRL 1021

		            VP+FF +

		Sbjct: 1021 VPVFFVV 1027

		

		

		

		 Score = 89.5 bits (222), Expect = 4e-20

		 Identities = 91/526 (17%), Positives = 177/526 (33%), Gaps = 50/526 (9%)

		

		Query: 532  IRRPVRSLFLYALIIAGAGYLYLTLPTSFLPEEDQGNFMAMVSLP-AGTLQKETSVRLRE 590

		            IRRP+ +  L  +++       L LP +  P           + P A     + +V  + 

		Sbjct: 6    IRRPIFAWVLAIILMMAGALAILQLPVAQYPTIAPPAVSVSANYPGADAQTVQDTV-TQV 64

		

		Query: 591  VEDYLMRHEPVEHVYSVGGFSFMGSGTNMAMLFVGLKNWDERPGENSSVQAIIDR----- 645

		            +E  +   + + ++ S    +  GS T       G      +    + +Q          

		Sbjct: 65   IEQNMNGIDNLMYMSSTSDSA--GSVTITLTFQSGTDPDIAQVQVQNKLQLATPLLPQEV 122

		

		Query: 646  ----VNARFAGDGQMMVMALNMPALPELGNSSGFDFRLQDKGGLGYARMAEARDELLARA 701

		                ++   +    +MV             S        D      + + +     L+R 

		Sbjct: 123  QQQGISVEKSSSSYLMVAGFV---------SDNPGTTQDDISDYVASNVKDT----LSRL 169

		

		Query: 702  NANPNLAGVYFSGQADTPRLHVSIDREKAFSMGVPIAEISNSLAV----MFGSSYVGDFM 757

		                 +  V   G      + + +D +      +   ++ N L V    +      G   

		Sbjct: 170  ---NGVGDVQLFGAQY--AMRIWLDADLLNKYKLTPVDVINQLKVQNDQIAAGQLGGTPA 224

		

		Query: 758  HDSQVRRIMVQADGKSRLNGNDIEDLHVR-NDQGKLLPLSSF--VRLDWTAGPPQLTRYN 814

		               Q     + A  + + N  +   + +R N  G ++ L     V L        + R N

		Sbjct: 225  LPGQQLNASIIAQTRFK-NPEEFGKVTLRVNSDGSVVRLKDVARVELG-GENYNVIARIN 282

		

		Query: 815  NYPSFTINGSSAPGKSSGDAMNA----LEQITASLPQGVGFEW---TGQSYEEKLAGSQA 867

		              P+  +    A G ++ D   A    L ++    PQG+   +   T    +  +     

		Sbjct: 283  GKPAAGLGIKLATGANALDTAKAIKAKLAELQPFFPQGMKVLYPYDTTPFVQLSIHEVVK 342

		

		Query: 868  TLLFGLSILIVFLVLAALYESWSIPLAVILVVPLGLLGALLAVFLRDMPNDIYFKVGLIT 927

		            TL     I++VFLV+    ++    L   + VP+ LLG    +       +     G++ 

		Sbjct: 343  TLFEA--IMLVFLVMYLFLQNMRATLIPTIAVPVVLLGTFAILAAFGYSINTLTMFGMVL 400

		

		Query: 928  TIGLSAKNAILIVE-VAREFYREGMNAAEAAVAAAKLRLRPILMTSLAFGAGVIPLAFAH 986

		             IGL   +AI++VE V R    + +   EA   +       ++  ++   A  IP+AF  

		Sbjct: 401  AIGLLVDDAIVVVENVERVMMEDKLPPKEATEKSMSQIQGALVGIAMVLSAVFIPMAFFG 460

		

		Query: 987  GAAAGAQRAVGTGVLGGIITATLLAIFLVPLFFRLTAGKRGPDHPE 1032

		            G+     R     ++  +  + L+A+ L P            +H E

		Sbjct: 461  GSTGAIYRQFSITIVSAMALSVLVALILTPALCATLLKPVSAEHHE 506

		

		

		>RTXTOXIND#Gram-negative bacterial RTX secretion protein D

		           signature.

		          Length = 478

		

		 Score = 44.8 bits (106), Expect = 3e-07

		 Identities = 22/139 (15%), Positives = 44/139 (31%), Gaps = 7/139 (5%)

		

		Query: 65  EVRARVTGIIQERCYQEGQTVRPGDLLFKIDP-------APLQAVLDECKAAVARARAVL 117

		           E++     I++E   +EG++VR GD+L K+            Q+ L + +    R + + 

		Sbjct: 98  EIKPIENSIVKEIIVKEGESVRKGDVLLKLTALGAEADTLKTQSSLLQARLEQTRYQILS 157

		

		Query: 118 SDAEDKAARYSSLVAKGAVSIREHKQARAEEERARAEYAAAAASLEQARLNLEYTRVEAP 177

		              E        L  +        ++        + +++       Q  LNL+  R E  

		Sbjct: 158 RSIELNKLPELKLPDEPYFQNVSEEEVLRLTSLIKEQFSTWQNQKYQKELNLDKKRAERL 217

		

		Query: 178 ISGRVRRALVTEGAFANQN 196

		                              

		Sbjct: 218 TVLARINRYENLSRVEKSR 236

		

		

		

		 Score = 31.0 bits (70), Expect = 0.010

		 Identities = 12/94 (12%), Positives = 32/94 (34%), Gaps = 10/94 (10%)

		

		Query: 99  LQAVLDECKAAVARARAVLSDAEDKAARYSSLVAKGAVSIREHKQARAEEERARAEYAAA 158

		               L   K+ + +  + +  A+++    + L            +   +  +        

		Sbjct: 264 AVNELRVYKSQLEQIESEILSAKEEYQLVTQLF---------KNEILDKLRQTTDNIGLL 314

		

		Query: 159 AASLEQARLNLEYTRVEAPISGRV-RRALVTEGA 191

		              L +     + + + AP+S +V +  + TEG 

		Sbjct: 315 TLELAKNEERQQASVIRAPVSVKVQQLKVHTEGG 348

		

		

		>GPOSANCHOR#Gram-positive coccus surface protein anchor signature.

		          Length = 539

		

		 Score = 31.2 bits (70), Expect = 0.012

		 Identities = 43/250 (17%), Positives = 64/250 (25%), Gaps = 35/250 (14%)

		

		Query: 148 DAFGEHAPLVHAYSDAWRQWQDARRAYDDLEHAEAATAREIELLRHQVDEIDSAAFTPEE 207

		           +   E +          +   +      +LE  +A   + +E   +      +   T E 

		Sbjct: 89  ELTEELSNAKEKLRKNDKSLSEKASKIQELEARKADLEKALEGAMNFSTADSAKIKTLEA 148

		

		Query: 208 VL--------TLEERWQRARNGTRLREQVSKMLS---MLEETDVPGLGTQLREL------ 250

		                      LE+  + A N +       K L       E     L   L         

		Sbjct: 149 EKAALAARKADLEKALEGAMNFSTADSAKIKTLEAEKAALEARQAELEKALEGAMNFSTA 208

		

		Query: 251 -TRAAHELERMDASTAAWLAPLAGVNLELKEIEGRLADYSAELDCDPRELFQLEERINLL 309

		            +     LE   A+ AA  A L              +     L+    E   LE R   L

		Sbjct: 209 DSAKIKTLEAEKAALAARKADLEKALEGAMNFSTADSAKIKTLE---AEKAALEARQAEL 265

		

		Query: 310 ESLKMKYGPSFEDVCSRREEAASRLDRIEHRTERLEELRASIAVLRKQMDAAGQALTRAR 369

		           E                   + +   +I+        L A  A L  Q     Q L   R

		Sbjct: 266 EKALEGA----------MNFSTADSAKIKTLEAEKAALEAEKADLEHQS----QVLNANR 311

		

		Query: 370 QDSAPRLAAS 379

		           Q     L AS

		Sbjct: 312 QSLRRDLDAS 321

		

		

		>MECHCHANNEL#Bacterial mechano-sensitive ion channel signature.

		          Length = 136

		

		 Score =  126 bits (317), Expect = 2e-40

		 Identities = 63/132 (47%), Positives = 86/132 (65%), Gaps = 8/132 (6%)

		

		Query: 9   GFLEEFKAFALKGNVIDLAVAVVIGGAFNKIVSVFVSSIITPIIGYLTSGVNLAYLVLKL 68

		             ++EF+ FA++GNV+DLAV V+IG AF KIVS  V+ II P +G L  G++     + L

		Sbjct: 2   SIIKEFREFAMRGNVVDLAVGVIIGAAFGKIVSSLVADIIMPPLGLLIGGIDFKQFAVTL 61

		

		Query: 69  GD-------VELKYGELLQATIDFLIIAFSVFVAIKLIGALRRKSEEAPAAPAPKPDDVV 121

		            D       V + YG  +Q   DFLI+AF++F+AIKLI  L RK EE  AAPAP   + V

		Sbjct: 62  RDAQGDIPAVVMHYGVFIQNVFDFLIVAFAIFMAIKLINKLNRKKEEPAAAPAPT-KEEV 120

		

		Query: 122 LLEQIRDILQKQ 133

		           LL +IRD+L++Q

		Sbjct: 121 LLTEIRDLLKEQ 132

		

		

		>SECGEXPORT#Protein-export SecG membrane protein signature.

		          Length = 110

		

		 Score = 49.2 bits (117), Expect = 1e-10

		 Identities = 26/107 (24%), Positives = 52/107 (48%), Gaps = 2/107 (1%)

		

		Query: 14  QLLFAVLVIVSLLLLGVVLMQRPKQEGLGAAFGAAITDQAFGAR-TTDVLKKATVYFGTA 72

		           + L  V +IV++ L+G++++Q+ K   +GA+FGA  +   FG+  + + + + T    T 

		Sbjct: 3   EALLVVFLIVAIGLVGLIMLQQGKGADMGASFGAGASATLFGSSGSGNFMTRMTALLATL 62

		

		Query: 73  FMVLCLGLGMLINRQHVKSSESLLSPEMMKAAARQEASVPAKTPEEL 119

		           F ++ L LG  IN           +        + + + PAK   ++

		Sbjct: 63  FFIISLVLGN-INSNKTNKGSEWENLSAPAKTEQTQPAAPAKPTSDI 108

		

		

		>BCTERIALGSPG#Bacterial general secretion pathway protein G

		          signature.

		          Length = 145

		

		 Score = 60.7 bits (147), Expect = 4e-14

		 Identities = 26/63 (41%), Positives = 37/63 (58%)

		

		Query: 8  RKSKGFTLIELLVVIAIILTLAGIAMTVVNGVMEKSKVTTARSDCNGLQTAVENYMLDNG 67

		           K +GFTL+E++VVI II  LA + +  + G  EK+    A SD   L+ A++ Y LDN 

		Sbjct: 5  DKQRGFTLLEIMVVIVIIGVLASLVVPNLMGNKEKADKQKAVSDIVALENALDMYKLDNH 64

		

		Query: 68 RVP 70

		            P

		Sbjct: 65 HYP 67

		

		

		>V8PROTEASE#V8 serine protease family signature.

		          Length = 336

		

		 Score = 77.0 bits (189), Expect = 2e-17

		 Identities = 42/212 (19%), Positives = 81/212 (38%), Gaps = 43/212 (20%)

		

		Query: 50  YKGVVKIEMDSLTPDYATPWNTGRYQGGIGTGFLIGENAFMTNAHVVSNAERIYI----- 104

		           Y  V  I++++ T  +            I +G ++G++  +TN HVV             

		Sbjct: 87  YAPVTYIQVEAPTGTF------------IASGVVVGKDTLLTNKHVVDATHGDPHALKAF 134

		

		Query: 105 ------SMYGDSRKIPARVKFIAHDADLALLE----ADDPRPFKGIRPFEFSKN-LPHLE 153

		                   Y +      ++   + + DLA+++      +    + ++P   S N    + 

		Sbjct: 135 PSAINQDNYPNGGFTAEQITKYSGEGDLAIVKFSPNEQNKHIGEVVKPATMSNNAETQVN 194

		

		Query: 154 DEVRVIGYPIGGNR--LSVTRGVVSRIDFTTYAHPRNTEHLTIQVDAAINPGNSGGPVLM 211

		             + V GYP       +  ++G ++ +           +   +Q D +   GNSG PV  

		Sbjct: 195 QNITVTGYPGDKPVATMWESKGKITYL-----------KGEAMQYDLSTTGGNSGSPVFN 243

		

		Query: 212 GNK-VIGVAFQGLNNANNTGYVIPTPVIRHFL 242

		               VIG+ + G+ N  N    I    +R+FL

		Sbjct: 244 EKNEVIGIHWGGVPNEFNGAVFI-NENVRNFL 274

		

		

		>PF03544#Gram-negative bacterial tonB protein

		          Length = 243

		

		 Score = 30.3 bits (68), Expect = 0.006

		 Identities = 24/102 (23%), Positives = 36/102 (35%), Gaps = 10/102 (9%)

		

		Query: 52  LVVLLLLHLLVIGGVYVRSTWFRNTAETVEMAAALPAPPTVPQRPAPAAPPAALPQVPQA 111

		            ++ + +H  V+ G+   S         V     LPAP         A      PQ  Q 

		Sbjct: 18  TLLSVCIHGAVVAGLLYTS---------VHQVIELPAPAQPISVTMVAPADLEPPQAVQP 68

		

		Query: 112 PPAAPVTITQPEQVVDARPNRQPAPAVEEHIPDAAPVAGPAR 153

		           PP  PV   +PE      P ++    +E+  P   P   P +

		Sbjct: 69  PPE-PVVEPEPEPEPIPEPPKEAPVVIEKPKPKPKPKPKPVK 109

		

		

		

		 Score = 28.0 bits (62), Expect = 0.039

		 Identities = 12/85 (14%), Positives = 20/85 (23%)

		

		Query: 85  ALPAPPTVPQRPAPAAPPAALPQVPQAPPAAPVTITQPEQVVDARPNRQPAPAVEEHIPD 144

		           A         +P P   P    + P+       +         A      + A       

		Sbjct: 90  APVVIEKPKPKPKPKPKPVKKVEQPKRDVKPVESRPASPFENTAPARPTSSTATAATSKP 149

		

		Query: 145 AAPVAGPARHIVRTGDTWERVARDN 169

		              VA   R + R    +   A+  

		Sbjct: 150 VTSVASGPRALSRNQPQYPARAQAL 174

		

		

		>NUCEPIMERASE#Nucleotide sugar epimerase signature.

		          Length = 334

		

		 Score = 29.8 bits (67), Expect = 0.029

		 Identities = 20/79 (25%), Positives = 31/79 (39%), Gaps = 11/79 (13%)

		

		Query: 247 GGH-TELLLEQGATVWGIDR-----DADARRAAMLRLARFGSRFKVLAGNFQD---VESI 297

		           G H ++ LLE G  V GID      D   ++A +  LA+    F+    +  D   +  +

		Sbjct: 13  GFHVSKRLLEAGHQVVGIDNLNDYYDVSLKQARLELLAQ--PGFQFHKIDLADREGMTDL 70

		

		Query: 298 LSQQGVSRVDGLLADLGVS 316

		            +     RV      L V 

		Sbjct: 71  FASGHFERVFISPHRLAVR 89

		

		

		>PF07520#Virulence protein SrfB

		          Length = 1041

		

		 Score = 28.4 bits (63), Expect = 0.014

		 Identities = 12/38 (31%), Positives = 19/38 (50%)

		

		Query: 33  GCALLLLSGRRLDLPTVKAYTREKFQQLIDKIETTPGY 70

		           GC ++LL+GR   LP V+A   E       ++ +   Y

		Sbjct: 803 GCDVVLLTGRPSRLPAVRAIVEEMLVVPPHRLISMHRY 840

		

		

		>PF05704#Capsular polysaccharide synthesis protein

		          Length = 307

		

		 Score = 39.9 bits (93), Expect = 2e-05

		 Identities = 23/118 (19%), Positives = 40/118 (33%), Gaps = 22/118 (18%)

		

		Query: 1   MNTRTVTSLWVGGE--LPLMSVLCIKSFLDH--GHAFQLFT---YRNYDNIPAGTLVRDA 53

		           M  + +   W+ G    P +   C+ S   +       +     Y+ + +IP        

		Sbjct: 66  MRQKYIFICWLQGIEKAPYIVQQCVASVKKNSGDFKVIIIDGNNYKEWVDIP-------- 117

		

		Query: 54  RDILPEEAIFHDSHNSLAPFSDWFRMKFLSQEGGFWVDMDVICLGDELPTSPLWFCRE 111

		            D L +   + +     A FSD  R+  L + GG W+D  V          P +    

		Sbjct: 118 -DFLIKR--WQEGKMLDAWFSDILRLFLLCKYGGLWIDATVYMFDKV----PNYIVES 168

		

		

		>RTXTOXINA#Gram-negative bacterial RTX toxin determinant A family

		           signature.

		          Length = 1024

		

		 Score = 32.2 bits (73), Expect = 6e-05

		 Identities = 15/33 (45%), Positives = 21/33 (63%), Gaps = 1/33 (3%)

		

		Query: 3   SGAIGSAGAGVGAAP-GSVVGARIGALIGDVTG 34

		           S  + S  +G+ AA   S+VGA + AL+G VTG

		Sbjct: 372 STVLASVSSGISAAATTSLVGAPVSALVGAVTG 404

		

		

		>60KDINNERMP#60kDa inner membrane protein signature.

		          Length = 548

		

		 Score = 26.8 bits (59), Expect = 0.018

		 Identities = 16/70 (22%), Positives = 28/70 (40%), Gaps = 6/70 (8%)

		

		Query: 8   IKDTGSWSPFYYW-IVGVVTMCALMWMLPNNYPREPWENIIRVLLGALFIFLFFVCPVWM 66

		           I D  +  P+Y   I+  VTM  +  M P     +P +  I   +  +F   F   P  +

		Sbjct: 455 IHDLSAQDPYYILPILMGVTMFFIQKMSPTTVT-DPMQQKIMTFMPVIFTVFFLWFPSGL 513

		

		Query: 67  IISAIRYWKT 76

		           ++    Y+  

		Sbjct: 514 VL----YYIV 519

		

		

		>PF07201#Hypersensitivity response secretion protein HrpJ

		          Length = 293

		

		 Score = 30.6 bits (69), Expect = 0.004

		 Identities = 18/113 (15%), Positives = 41/113 (36%), Gaps = 20/113 (17%)

		

		Query: 96  RIDSFLKKHPYLERKDVPSEMVTASASGLDPHITPESAY---------------VQVKRV 140

		           +++ +L K P LE+K   SE+++  ++  +  ++   AY                 ++  

		Sbjct: 86  QVNQYLSKVPELEQKQNVSELLSLLSNSPNISLSQLKAYLEGKSEEPSEQFKMLCGLRDA 145

		

		Query: 141 AKARGMEEGAVRSLVDQAVEKPLLGMFGTE---KVNVLKLNIALEKADPSGKH 190

		            K R  E   +  LV+QA+   +    G        +        ++  +   

		Sbjct: 146 LKGRP-ELAHLSHLVEQALVS-MAEEQGETIVLGARITPEAYRESQSGVNPLQ 196

		

		

		>ACRIFLAVINRP#Acriflavin resistance protein family signature.

		          Length = 1034

		

		 Score = 32.5 bits (74), Expect = 0.003

		 Identities = 15/57 (26%), Positives = 22/57 (38%), Gaps = 2/57 (3%)

		

		Query: 44  QLNEETKRLIASYRRDPSEANRLALRKQVGINYDKVLDRKKAKLEELKRTARHASKI 100

		           +L  E   +IA     P+    L ++   G N        KAKL EL+       K+

		Sbjct: 269 ELGGENYNVIARINGKPAAG--LGIKLATGANALDTAKAIKAKLAELQPFFPQGMKV 323

		

		

		>YERSSTKINASE#Yersinia serine/threonine protein kinase signature.

		          Length = 732

		

		 Score = 32.4 bits (73), Expect = 0.009

		 Identities = 30/104 (28%), Positives = 46/104 (44%), Gaps = 10/104 (9%)

		

		Query: 188 RCGILHRDIKPANLLLDEA-GEVHVSDFGLAFLLQGRNEVIEKEGAQSGTLRYMSPERLV 246

		           + G++H DIKP N++ D A GE  V D G    L  R+     E  +  T  + +PE  V

		Sbjct: 263 KAGVVHNDIKPGNVVFDRASGEPVVIDLG----LHSRS----GEQPKGFTESFKAPELGV 314

		

		Query: 247 HGVN-TFSSDQYAFGVTLYELVAKSPPFPGLAPEELMERICREP 289

		             +  +  SD +    TL   +      P + P + +  I  EP

		Sbjct: 315 GNLGASEKSDVFLVVSTLLHCIEGFEKNPEIKPNQGLRFITSEP 358

		

		

		>SHIGARICIN#Ribosome inactivating protein family signature.

		          Length = 289

		

		 Score = 29.0 bits (65), Expect = 0.045

		 Identities = 18/77 (23%), Positives = 27/77 (35%), Gaps = 14/77 (18%)

		

		Query: 67  ILAVLLLTWVLAAPVWPGKGSGQTVVFILD--DSANMAPFRQEAVNAVSEDMDTILRCGI 124

		           + ++L+LT  L AP   G      V F L    S++   F      A+           I

		Sbjct: 6   VFSLLILTLFLTAPAVEG-----DVSFRLSGATSSSYGVFISNLRKALP---YERKLYDI 57

		

		Query: 125 PVTWVLMGSRASGQPLY 141

		           P+    + S   G   Y

		Sbjct: 58  PL----LRSTLPGSQRY 70

		

		

		>BCTERIALGSPD#Bacterial general secretion pathway protein D

		           signature.

		          Length = 660

		

		 Score = 26.8 bits (59), Expect = 0.015

		 Identities = 16/75 (21%), Positives = 26/75 (34%), Gaps = 8/75 (10%)

		

		Query: 27  QTVTTEGAGGKLKVTATC-DGNLTELVIDPSIIDPSDSEFLQELLLQTINAAIAKGKETA 85

		            TV  +  G KLKV     +G+   L I+  +   +D+          + A         

		Sbjct: 477 NTVERKTVGIKLKVKPQINEGDSVLLEIEQEVSSVADA---ASSTSSDLGATFNTRTVNN 533

		

		Query: 86  AAEMKK----LTGGL 96

		           A  +      + GGL

		Sbjct: 534 AVLVGSGETVVVGGL 548

		

		

		>TONBPROTEIN#Gram-negative bacterial tonB protein signature.

		          Length = 239

		

		 Score = 30.7 bits (69), Expect = 0.014

		 Identities = 11/43 (25%), Positives = 17/43 (39%)

		

		Query: 651 PEPVQEELAPLPAPPPSASTIPAPKPHTPQKKTAEPVQEASKE 693

		           PEP  E +   P   P     P PKP    K   +  ++  ++

		Sbjct: 71  PEPEPEPIPEPPKEAPVVIEKPKPKPKPKPKPVKKVQEQPKRD 113

		

		

		>ANTHRAXTOXNA#Anthrax toxin LF subunit signature.

		          Length = 800

		

		 Score = 25.9 bits (56), Expect = 0.016

		 Identities = 10/21 (47%), Positives = 16/21 (76%)

		

		Query: 29  TVFSGKDLVTHGSERLEDEFP 49

		           T ++G D+V HG+E+  +EFP

		Sbjct: 567 TGYTGGDVVNHGTEQDNEEFP 587

		

		

		>GPOSANCHOR#Gram-positive coccus surface protein anchor signature.

		          Length = 539

		

		 Score = 30.8 bits (69), Expect = 0.006

		 Identities = 27/151 (17%), Positives = 61/151 (40%), Gaps = 4/151 (2%)

		

		Query: 23  DNEEALTKERRECASRYKNLNGLRGEFTEEKTKYVDFLVKNEALTNDINALTKEKDELEV 82

		            +   +     E A+       L                K + L  +  AL  EK +LE 

		Sbjct: 243 ADSAKIKTLEAEKAALEARQAELEKALEGAMNFSTADSAKIKTLEAEKAALEAEKADLEH 302

		

		Query: 83  KNQELASANEAKKSDLQTQQTALAELQSKSKDMESIQAIADR-IKGLEEESKQLEVVKQA 141

		           ++Q L +  ++ + DL   + A  +L+++ + +E    I++   + L  +       K+ 

		Sbjct: 303 QSQVLNANRQSLRRDLDASREAKKQLEAEHQKLEEQNKISEASRQSLRRDLDASREAKKQ 362

		

		Query: 142 EQGKHDAIVAETEQLVVNNAALRQLKADQDA 172

		            + +H  +  + +   ++ A+ + L+ D DA

		Sbjct: 363 LEAEHQKLEEQNK---ISEASRQSLRRDLDA 390

		

		

		

		 Score = 30.8 bits (69), Expect = 0.006

		 Identities = 20/108 (18%), Positives = 33/108 (30%), Gaps = 1/108 (0%)

		

		Query: 62  KNEALTNDINALTKEKDELEVKNQELASANEAKKSDLQTQQTALAELQSKSKDM-ESIQA 120

		           +   L   +            K + L +   A  +     + AL    + S      I+ 

		Sbjct: 191 RQAELEKALEGAMNFSTADSAKIKTLEAEKAALAARKADLEKALEGAMNFSTADSAKIKT 250

		

		Query: 121 IADRIKGLEEESKQLEVVKQAEQGKHDAIVAETEQLVVNNAALRQLKA 168

		           +      LE    +LE   +       A  A+ + L    AAL   KA

		Sbjct: 251 LEAEKAALEARQAELEKALEGAMNFSTADSAKIKTLEAEKAALEAEKA 298

		

		

		

		 Score = 27.7 bits (61), Expect = 0.047

		 Identities = 20/104 (19%), Positives = 39/104 (37%), Gaps = 1/104 (0%)

		

		Query: 62  KNEALTNDINALTKEKDELEVKNQELASANEAKKSDLQTQQTALAELQSKSKDME-SIQA 120

		           KN  L+ +  AL    DEL  +              L  + + + EL+++  D+E +++ 

		Sbjct: 72  KNSDLSFNNKALKDHNDELTEELSNAKEKLRKNDKSLSEKASKIQELEARKADLEKALEG 131

		

		Query: 121 IADRIKGLEEESKQLEVVKQAEQGKHDAIVAETEQLVVNNAALR 164

		             +       + K LE  K A   +   +    E  +  + A  

		Sbjct: 132 AMNFSTADSAKIKTLEAEKAALAARKADLEKALEGAMNFSTADS 175

		

		

		>GPOSANCHOR#Gram-positive coccus surface protein anchor signature.

		          Length = 539

		

		 Score = 33.1 bits (75), Expect = 0.001

		 Identities = 25/148 (16%), Positives = 57/148 (38%), Gaps = 6/148 (4%)

		

		Query: 48  EIRTWTSLRNDMIKNRGLAAEENLSLISNKASVTQQRDEQLSKEAELKEEEVQLNADLSK 107

		            +       +           +N  L  N  ++    DE   + +  KE+  + +  LS+

		Sbjct: 51  TLEKVQERADKFEIENNTLKLKNSDLSFNNKALKDHNDELTEELSNAKEKLRKNDKSLSE 110

		

		Query: 108 INKQIEELKSKLQDFG------VSSVQEIQEKMESLEASNKKLQEDIDQIKSATEVASKR 161

		              +I+EL+++  D        ++       K+++LEA    L      ++ A E A   

		Sbjct: 111 KASKIQELEARKADLEKALEGAMNFSTADSAKIKTLEAEKAALAARKADLEKALEGAMNF 170

		

		Query: 162 RAEQASELASRQKEQAEYRAALAKNGEE 189

		               ++++ + + E+A   A  A+  + 

		Sbjct: 171 STADSAKIKTLEAEKAALEARQAELEKA 198

		

		

		>PF05616#Neisseria meningitidis TspB protein

		          Length = 501

		

		 Score = 31.3 bits (70), Expect = 0.003

		 Identities = 16/42 (38%), Positives = 25/42 (59%), Gaps = 4/42 (9%)

		

		Query: 30  PSASGRPSLANPAPEPTPADDEQPNPPPPSDPGS---PQGDP 68

		           P ++  P+ A P PE +PA++   NP P  +PG+   P+ DP

		Sbjct: 317 PGSAEAPN-AQPLPEVSPAENPANNPAPNENPGTRPNPEPDP 357

		

		

		>STREPKINASE#Streptococcus streptokinase protein signature.

		          Length = 440

		

		 Score = 28.9 bits (64), Expect = 0.011

		 Identities = 16/57 (28%), Positives = 24/57 (42%)

		

		Query: 13  TGARGNGLEEHDVACVIARHLFAQLKDMGHTVHVLDFPDKGNTEDLNATIKVANADG 69

		           +GA  + LE+ D+   I   L A +        V+DF       D N  +  A+ DG

		Sbjct: 93  SGAMSHKLEKADLLKAIQEQLIANVHSNDDYFEVIDFASDATITDRNGKVYFADKDG 149

		

		

		>IGASERPTASE#IgA-specific serine endopeptidase (S6) signature.

		          Length = 1541

		

		 Score = 32.0 bits (72), Expect = 0.010

		 Identities = 28/228 (12%), Positives = 61/228 (26%), Gaps = 11/228 (4%)

		

		Query: 135  LSNTASIIAAQQAQQNANTSSTNAETASQAAKTATDA------AATAAARAEEAEGYAGS 188

		            +   A    ++  +  A  S   ++T  +  + AT+        A  A    +A      

		Sbjct: 1025 VPPPAPATPSETTETVAENSKQESKTVEKNEQDATETTAQNREVAKEAKSNVKANTQTNE 1084

		

		Query: 189  AWASKSAAADSATAAG--TSATNAARDAKSANDAKTDVESLAATWP--ETVSNGEKKIVD 244

		               S S   ++ T     T+       AK   +   +V  + +     +  S   +   +

		Sbjct: 1085 VAQSGSETKETQTTETKETATVEKEEKAKVETEKTQEVPKVTSQVSPKQEQSETVQPQAE 1144

		

		Query: 245  AGNEAVTAIQDKQADSVLAVGRASQTAQQNIAGARTDAVAAVQTAQERAVGAITPLVQRA 304

		               E    +  K+  S       ++   +  +      V    T          P     

		Sbjct: 1145 PARENDPTVNIKEPQSQTNTTADTEQPAKETSSNVEQPVTESTTVNTGNSVVENPENTTP 1204

		

		Query: 305  ETAKEAIDQA-EGRINTAATNAATSATSAANSATEAQQALEAIPQVDA 351

		             T +  ++     +       +  S       AT +      +   D 

		Sbjct: 1205 ATTQPTVNSESSNKPKNRHRRSVRSVPHNVEPATTSSNDRSTVALCDL 1252

		

		

		>SECA#SecA protein signature.

		          Length = 901

		

		 Score = 30.2 bits (68), Expect = 0.013

		 Identities = 16/49 (32%), Positives = 22/49 (44%), Gaps = 9/49 (18%)

		

		Query: 18  LVPAFLASCREASERQDQIRFGLFPNVTHVQGLVARHFS-----RTGEG 61

		           L+P   A  REAS+R     FG+      + G +  +       RTGEG

		Sbjct: 63  LIPEAFAVVREASKR----VFGMRHFDVQLLGGMVLNERCIAEMRTGEG 107

		

		

		>TCRTETOQM#Tetracycline resistance protein TetO/TetQ/TetM family

		           signature.

		          Length = 639

		

		 Score = 56.8 bits (137), Expect = 1e-10

		 Identities = 45/137 (32%), Positives = 60/137 (43%), Gaps = 17/137 (12%)

		

		Query: 24  VDDGKSTLIGRLLYDSKLIFDDQLAELRKASEKNGTAGAGKIDYALLLDGLRAEREQGIT 83

		           VD GK+TL   LLY+S  I   +L  + K     GT            D    ER++GIT

		Sbjct: 12  VDAGKTTLTESLLYNSGAI--TELGSVDK-----GTT---------RTDNTLLERQRGIT 55

		

		Query: 84  IDVAYRYFTTPRRKFIIADCPGHEQYTRNMATGASTADAAIILIDARHGVLTQTKRHAFI 143

		           I      F     K  I D PGH  +   +    S  D AI+LI A+ GV  QT+     

		Sbjct: 56  IQTGITSFQWENTKVNIIDTPGHMDFLAEVYRSLSVLDGAILLISAKDGVQAQTRILFHA 115

		

		Query: 144 VSLLKIRHLIVAVNKMD 160

		           +  + I   I  +NK+D

		Sbjct: 116 LRKMGIP-TIFFINKID 131

		

		

		>RTXTOXIND#Gram-negative bacterial RTX secretion protein D

		           signature.

		          Length = 478

		

		 Score = 29.0 bits (65), Expect = 0.003

		 Identities = 12/35 (34%), Positives = 18/35 (51%), Gaps = 2/35 (5%)

		

		Query: 37  SDKGKVTIGETAQIKGDITAGDVRIYGNVEGKVTS 71

		            D G + +G+ A IK  + A     YG + GKV +

		Sbjct: 375 KDIGFINVGQNAIIK--VEAFPYTRYGYLVGKVKN 407

		

		

		>CARBMTKINASE#Bacterial carbamate kinase signature.

		          Length = 314

		

		 Score = 31.7 bits (72), Expect = 0.002

		 Identities = 15/62 (24%), Positives = 23/62 (37%), Gaps = 13/62 (20%)

		

		Query: 124 RSYLDNNKIVIFAAGTGNPFFST-------------DTTAALRASEINAEVVMKATSVDG 170

		           +  ++   IVI + G G P                 D      A E+NA++ M  T V+G

		Sbjct: 180 KKLVERGVIVIASGGGGVPVILEDGEIKGVEAVIDKDLAGEKLAEEVNADIFMILTDVNG 239

		

		Query: 171 VY 172

		             

		Sbjct: 240 AA 241

		

		

		>TCRTETA#Tetracycline resistance protein signature.

		          Length = 399

		

		 Score = 36.3 bits (84), Expect = 2e-04

		 Identities = 44/223 (19%), Positives = 81/223 (36%), Gaps = 18/223 (8%)

		

		Query: 133 TVSVAWSVLSDVMKPGQMKRLFALVASGSSLGAMAGPAVTAALAGVAGYLWLFLAAAVFL 192

		           T +VA + ++D+    +  R F  +++    G +AGP +   + G + +   F AAA+  

		Sbjct: 112 TGAVAGAYIADITDGDERARHFGFMSACFGFGMVAGPVLGGLMGGFSPHAPFFAAAALNG 171

		

		Query: 193 ALAMLAGMYLHRWRDGNSPEDEETGVLLPADCRERPLGGNPFAGASAVFRSPFLMG-IGL 251

		              +     L     G         +   A  R    G    A   AVF    L+G +  

		Sbjct: 172 LNFLTGCFLLPESHKGERRPLRREALNPLASFRWA-RGMTVVAALMAVFFIMQLVGQVPA 230

		

		Query: 252 FIILLAGTNTFLYFELMSVVASSFPDPVRQTQVFGALDVVVQGCTMLLQVFLAGRIVRKF 311

		            + ++ G + F +      ++ +          FG L         L Q  + G +  + 

		Sbjct: 231 ALWVIFGEDRFHWDATTIGISLA---------AFGILHS-------LAQAMITGPVAARL 274

		

		Query: 312 GLAALLAAVPVLISLGFVWMAFAPVFAVVAVVMAVRRIGEYGM 354

		           G    L    +    G++ +AFA    +   +M +   G  GM

		Sbjct: 275 GERRALMLGMIADGTGYILLAFATRGWMAFPIMVLLASGGIGM 317

		

		

		>ABC2TRNSPORT#ABC-2 type transport system membrane protein

		           signature.

		          Length = 262

		

		 Score = 56.5 bits (136), Expect = 3e-11

		 Identities = 36/190 (18%), Positives = 79/190 (41%), Gaps = 7/190 (3%)

		

		Query: 176 FIVPGLIAVLVLINSILSG-SLSIAREREEGTFDQLLVAPYTPGEILLGKGTASVVTGIM 234

		           F+  G++A   +  +       +  R   + T++ +L      G+I+LG+   +     +

		Sbjct: 68  FLAAGMVATSAMTAATFETIYAAFGRMEGQRTWEAMLYTQLRLGDIVLGEMAWAATKAAL 127

		

		Query: 235 QAVFVVLVAMFWFRIPFQGSIWLLSAALLLFIVTAAAIGLCISSFAQSLQQAIVGTFLLL 294

		               + +VA       +   ++ L    L  +  A+ +G+ +++ A S    I    L++

		Sbjct: 128 AGAGIGVVAAALGYTQWLSLLYALPVIALTGLAFAS-LGMVVTALAPSYDYFIFYQTLVI 186

		

		Query: 295 VPMVMLSGFATPISSMPEIFQDLTLLNPMRYGLELIQRIFLEGAG-----FLDLWPLFAA 349

		            P++ LSG   P+  +P +FQ      P+ + ++LI+ I L          +    ++  

		Sbjct: 187 TPILFLSGAVFPVDQLPIVFQTAARFLPLSHSIDLIRPIMLGHPVVDVCQHVGALCIYIV 246

		

		Query: 350 IMAVTVAAVL 359

		           I      A+L

		Sbjct: 247 IPFFLSTALL 256

		

		

		>ABC2TRNSPORT#ABC-2 type transport system membrane protein

		           signature.

		          Length = 262

		

		 Score = 35.7 bits (82), Expect = 2e-04

		 Identities = 32/145 (22%), Positives = 59/145 (40%), Gaps = 2/145 (1%)

		

		Query: 196 AREYERGTLESLFVTPVGSGEILAAKAATNFLLGMVSLAISMLFAAFVFGIPIRGSLTLL 255

		            R   + T E++  T +  G+I+  + A       ++ A   + AA +       SL   

		Sbjct: 92  GRMEGQRTWEAMLYTQLRLGDIVLGEMAWAATKAALAGAGIGVVAAALGYTQ-WLSLLYA 150

		

		Query: 256 LAVSALFLIVALGLGLVISTATKNQFLACQFAIMGTFMPALMLSGFLYDILNMPPAVRAI 315

		           L V AL  +    LG+V+ TA    +    F       P L LSG ++ +  +P   +  

		Sbjct: 151 LPVIALTGLAFASLGMVV-TALAPSYDYFIFYQTLVITPILFLSGAVFPVDQLPIVFQTA 209

		

		Query: 316 TYLIPARYYVTLLQTLFLAGDIPSV 340

		              +P  + + L++ + L   +  V

		Sbjct: 210 ARFLPLSHSIDLIRPIMLGHPVVDV 234

		

		

		>RTXTOXIND#Gram-negative bacterial RTX secretion protein D

		           signature.

		          Length = 478

		

		 Score = 75.3 bits (185), Expect = 4e-17

		 Identities = 46/287 (16%), Positives = 98/287 (34%), Gaps = 31/287 (10%)

		

		Query: 67  PGQKLATLETVRLRQAADEARQIAEAARQNYLRVKNGPRAEEIAQARANVQAAEATLNNA 126

		           P  +  + E V    +  + +      ++    +    +  E     A +   E      

		Sbjct: 174 PYFQNVSEEEVLRLTSLIKEQFSTWQNQKYQKELNLDKKRAERLTVLARINRYENLSRVE 233

		

		Query: 127 GMRSKRLEALAETKSISRQEADDAVASRQVAAANLDVARKQLELLLAGSRE--------- 177

		             R     +L   ++I++    +       A   L V + QLE + +             

		Sbjct: 234 KSRLDDFSSLLHKQAIAKHAVLEQENKYVEAVNELRVYKSQLEQIESEILSAKEEYQLVT 293

		

		Query: 178 --------EDVAQALAQYNQAKASLTIREQNLKDAVLYAPGNGVVRN-RILEKGDMASPQ 228

		                   + + Q           L   E+  + +V+ AP +  V+  ++  +G + +  

		Sbjct: 294 QLFKNEILDKLRQTTDNIGLLTLELAKNEERQQASVIRAPVSVKVQQLKVHTEGGVVTTA 353

		

		Query: 229 KPVYNIS-LNHTKWVRAYLTESQLGKVKPGFSATVRNDSFPDTGFKGTVGFISSVAEFTP 287

		           + +  I   + T  V A +    +G +  G +A ++ ++FP T +   VG + ++     

		Sbjct: 354 ETLMVIVPEDDTLEVTALVQNKDIGFINVGQNAIIKVEAFPYTRYGYLVGKVKNINLDA- 412

		

		Query: 288 KNVETPDLRTALVYEVRIIVD-------DPDNRLRLGAPATVTIPLG 327

		                 D R  LV+ V I ++       + +  L  G   T  I  G

		Sbjct: 413 ----IEDQRLGLVFNVIISIEENCLSTGNKNIPLSSGMAVTAEIKTG 455

		

		

		>PF05616#Neisseria meningitidis TspB protein

		          Length = 501

		

		 Score = 31.3 bits (70), Expect = 0.003

		 Identities = 23/66 (34%), Positives = 31/66 (46%), Gaps = 8/66 (12%)

		

		Query: 13  REEAIPGSEGEGPGGGAPPPASPVDSPPPANPPVPS-NPYDFSGGAEQPDPDPGSPPPLS 71

		           R +  PGS  E P     P  SP ++P  AN P P+ NP    G    P+PDP   P  +

		Sbjct: 312 RPDLTPGS-AEAPNAQPLPEVSPAENP--ANNPAPNENP----GTRPNPEPDPDLNPDAN 364

		

		Query: 72  PQEETE 77

		           P  + +

		Sbjct: 365 PDTDGQ 370

		

		

		>FLAGELLIN#Flagellin signature.

		          Length = 507

		

		 Score = 32.3 bits (73), Expect = 0.008

		 Identities = 22/217 (10%), Positives = 62/217 (28%), Gaps = 13/217 (5%)

		

		Query: 137 MATTAAQAFAYHALQASKNAHADAETASQAAKTATDAAATAATRTEEAEGYAGSAWASKR 196

		            A              + +     ++ +  A+    A A    +  +   Y G  +    

		Sbjct: 230 NAANGQLTTDDAENNTAVDLFKTTKSTAGTAEAKAIAGAIKGGKEGDTFDYKGVTFTIDT 289

		

		Query: 197 AAADSAAAADTSATNADRDAKSAHDAKTAVESLAATWPETVSNGEKKIVDAGNEAVTAIQ 256

		              +      ++  N ++   +  D      ++ A   ++  N    +V+         +

		Sbjct: 290 KTGNDGNGKVSTTINGEKVTLTVADITAGAANVDAATLQSSKNVYTSVVNGQFTFDDKTK 349

		

		Query: 257 DKQADSVLAVGRASQTAQQNIAGARTDAVAAVQTAQERAVGAITPLVQRAETAKEDIDQA 316

		           ++ A         +   +  I     +  A     +    G    + + A          

		Sbjct: 350 NESAKLSDLEANNAVKGESKITVNGAEYTANAAGDKVTLAGKTMFIDKTA---------- 399

		

		Query: 317 ERRINTAATNAANSATSAGNSATAAANALAAIPQVDE 353

		                 +     ++A +  ++A   A+  +A+ +VD 

		Sbjct: 400 ---SGVSTLINEDAAAAKKSTANPLASIDSALSKVDA 433

		

		

		>BLACTAMASEA#Beta-lactamase class A signature.

		          Length = 286

		

		 Score = 35.2 bits (81), Expect = 2e-04

		 Identities = 24/99 (24%), Positives = 42/99 (42%), Gaps = 3/99 (3%)

		

		Query: 20  QAQERPSYIAIEANSGKLLFSSNAEEKRPVASLSQVATAMVALDWVARTRLPLDTFIAVP 79

		           Q   R   I ++  SG+ L +  A+E+ P+ S  +V      L  V      L+  I   

		Sbjct: 35  QLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYR 94

		

		Query: 80  QEAFGLRAGNP-MDLQPGDRLTLRDALYSTLLGSDNVSA 117

		           Q+   L   +P  +    D +T+ +   + +  SDN +A

		Sbjct: 95  QQD--LVDYSPVSEKHLADGMTVGELCAAAITMSDNSAA 131