>PRTACTNFAMLY#Pertactin virulence factor family signature. Length = 910 Score = 70.9 bits (173), Expect = 2e-14 Identities = 100/403 (24%), Positives = 155/403 (38%), Gaps = 40/403 (9%) Query: 702 AFTLA--GGTVSAGAYSYYLVK--GGVTALTGEDWYLRSTVPPRPDQPTQQPPFSVADGT 757 FTLA G V G Y Y L G +L G P+P QPP Sbjct: 537 TFTLANKDGKVDIGTYRYRLAANGNGQWSLVGAKAPPAPKPAPQPGPQPPQPP-QPQPEA 595 Query: 758 PESIVEAVKNAAPDAKPEPVYRPEVPLYSEVPAVARQLGLLQIDTFHDRQGEQGLLAENG 817 P A + + A + + +A L + + R GE L + G Sbjct: 596 PAPQPPAGRELSAAAN--------AAVNTGGVGLASTLWYAESNALSKRLGELRLNPDAG 647 Query: 818 SVPVSWSRVWGGYSNIKQNGDVTPSYDGTVWGMQVGQDLYADNRPSGHRNHYGFFLGFSR 877 W R + + + +D V G ++G D +G R H G G++R Sbjct: 648 GA---WGRGFAQRQQL--DNRAGRRFDQKVAGFELGADHAVAV--AGGRWHLGGLAGYTR 700 Query: 878 AIGDVNGFALAQPDLGVGSLQVNAYNLGGYWTHIGPGGWYTDAVVMGSVL----TVRTHS 933 G G ++ ++GGY T+I G+Y DA + S L V Sbjct: 701 GDRGFTGD---------GGGHTDSVHVGGYATYIADSGFYLDATLRASRLENDFKVAGSD 751 Query: 934 NNNVSGSTDGNAVTGSVEAGVPISLGYGLTLEPQAQLLWQWLSLARF--NDGVSDVTWNN 991 V G + V S+EAG + G LEPQA+L + +G+ V Sbjct: 752 GYAVKGKYRTHGVGASLEAGRRFTHADGWFLEPQAELAVFRAGGGAYRAANGLR-VRDEG 810 Query: 992 GNTFLGRIGARLQYAFD-ANGVSWKPYLRVNVLRSFGSDDRTTFGGSTTIGTQVGQTAGQ 1050 G++ LGR+G + + A G +PY++ +VL+ F T T++ T + Sbjct: 811 GSSVLGRLGLEVGKRIELAGGRQVQPYIKASVLQEFDGAG-TVHTNGIAHRTELRGTRAE 869 Query: 1051 IGAGLVAQLTKRGSVYATVSYLTNLGGEHQRTITGNAGVRWAW 1093 +G G+ A L + S+YA+ Y G + T +AG R++W Sbjct: 870 LGLGMAAALGRGHSLYASYEYSK--GPKLAMPWTFHAGYRYSW 910
>PF07472#Fucose-binding lectin II Length = 245 Score = 408 bits (1050), Expect = e-148 Identities = 229/245 (93%), Positives = 233/245 (95%), Gaps = 1/245 (0%) Query: 1 MSQPFTHDDLYALLQLAGNDATAVQANGDQAVLDRMRQFMTAQLVEKLPQYDVFVDIATI 60 MSQPFTHDDLYALLQLAGNDATAVQANGDQAVLDRMRQFMT QLVEKLPQYDVFVDIATI Sbjct: 1 MSQPFTHDDLYALLQLAGNDATAVQANGDQAVLDRMRQFMTTQLVEKLPQYDVFVDIATI 60 Query: 61 PYSFDVGSWQNKVKTDAAGEVVACTVTWAGAPGVLPGAAAKFGVGAVVNYFSKATPQP-V 119 PYSFDVGSWQNKVK DAAG+V+ACTVTWAGAPGVLPGAAAKFGVGAVVNYFSKATPQP Sbjct: 61 PYSFDVGSWQNKVKADAAGQVIACTVTWAGAPGVLPGAAAKFGVGAVVNYFSKATPQPEP 120 Query: 120 QPAPVPTGGGERDGVFNLPPNIAFGVTALVNSSAPQTIEVFVDDNPKPAATFQGAGTQDA 179 TGGGERDG+FNLPPNIAFGVTALVNSSA QTIEV+VDDNPKPAATFQGAGTQDA Sbjct: 121 TQPGTTTGGGERDGIFNLPPNIAFGVTALVNSSAQQTIEVYVDDNPKPAATFQGAGTQDA 180 Query: 180 NLNTQIVNSGKGKVRVVVTANGKPSKIGSRQVDIFKKTYFGLVGSEDGGDGDYNDGIAIL 239 NLNTQIVNSGKGKVRVVVTANGKPSKIGSRQVDIFKKTYFGLVGSEDG DGDYNDGIAIL Sbjct: 181 NLNTQIVNSGKGKVRVVVTANGKPSKIGSRQVDIFKKTYFGLVGSEDGTDGDYNDGIAIL 240 Query: 240 NWPLG 244 NWPLG Sbjct: 241 NWPLG 245
>PF07472#Fucose-binding lectin II Length = 245 Score = 201 bits (511), Expect = 2e-66 Identities = 88/160 (55%), Positives = 114/160 (71%), Gaps = 17/160 (10%) Query: 113 GSAMHIDSYASLSAIGETAAPSSSQGGGNQGAETGGTGAGNIGGGERDGTFNLPPHIKFG 172 G ++ ++ + E P ++ GGG ERDG FNLPP+I FG Sbjct: 103 GVGAVVNYFSKATPQPEPTQPGTTTGGG-----------------ERDGIFNLPPNIAFG 145 Query: 173 VTALTHAANDQTIDIYIDDDPKPAATFKGAGAQDQNLGTKVLDSGNGRVRVIVMANGKPS 232 VTAL +++ QTI++Y+DD+PKPAATF+GAG QD NL T++++SG G+VRV+V ANGKPS Sbjct: 146 VTALVNSSAQQTIEVYVDDNPKPAATFQGAGTQDANLNTQIVNSGKGKVRVVVTANGKPS 205 Query: 233 RLGSRQVDIFKKSYFGIVGSEDGADDDYNDGIVFLNWPLG 272 ++GSRQVDIFKK+YFG+VGSEDG D DYNDGI LNWPLG Sbjct: 206 KIGSRQVDIFKKTYFGLVGSEDGTDGDYNDGIAILNWPLG 245
>PF07472#Fucose-binding lectin II Length = 245 Score = 148 bits (375), Expect = 5e-48 Identities = 50/128 (39%), Positives = 70/128 (54%), Gaps = 10/128 (7%) Query: 4 SQTSSNRAGEFSIPPNTDFRAIFFANAAEQQHIKLFIGDSQEPAA-YHKLTTRDGPREA- 61 + R G F++PPN F N++ QQ I++++ D+ +PAA + T+D Sbjct: 126 TTGGGERDGIFNLPPNIAFGVTALVNSSAQQTIEVYVDDNPKPAATFQGAGTQDANLNTQ 185 Query: 62 TLNSGNGKIRFEVSVNGKPSATDARLAPINGKKSDGSPFTVNFGIVVSEDGHDSDYNDGI 121 +NSG GK+R V+ NGKPS +R I K FG+V SEDG D DYNDGI Sbjct: 186 IVNSGKGKVRVVVTANGKPSKIGSRQVDIFKK--------TYFGLVGSEDGTDGDYNDGI 237 Query: 122 VVLQWPIG 129 +L WP+G Sbjct: 238 AILNWPLG 245
>ISCHRISMTASE#Isochorismatase signature. Length = 312 Score = 32.7 bits (74), Expect = 0.007 Identities = 21/66 (31%), Positives = 28/66 (42%), Gaps = 5/66 (7%) Query: 708 ATLLELAPDEIGRDASFFELGGHSLLVSRLMLAVK--RELGGNAALARFMERPTIAALAA 765 A LL+ P++I + G S+ R+M V+ R G ERPTI Sbjct: 240 AELLQETPEDITDQEDLLDRGLDSV---RIMTLVEQWRREGAEVTFVELAERPTIEEWQK 296 Query: 766 LLTDES 771 LLT S Sbjct: 297 LLTTRS 302
>PF07472#Fucose-binding lectin II Length = 245 Score = 26.9 bits (59), Expect = 0.036 Identities = 28/92 (30%), Positives = 47/92 (51%), Gaps = 11/92 (11%) Query: 50 ITGLDHTDMIGEGVRSL--RIKHFADGNVVVEQLNSHDDEAMVMTWSLIHTSFDIGNLWA 107 + G D T + G +++ R++ F +V E+L +D + + + I SFD+G+ Sbjct: 16 LAGNDATAVQANGDQAVLDRMRQFMTTQLV-EKLPQYD---VFVDIATIPYSFDVGSWQN 71 Query: 108 LMRVEPRGDQ-ACTVTWDIAGEPS--HGGAAR 136 ++ + G ACTVTW AG P G AA+ Sbjct: 72 KVKADAAGQVIACTVTW--AGAPGVLPGAAAK 101
>OUTRMMBRANEA#Outer membrane protein A signature. Length = 346 Score = 39.9 bits (93), Expect = 5e-06 Identities = 26/141 (18%), Positives = 46/141 (32%), Gaps = 18/141 (12%) Query: 66 GGPDGQDRVTGSVAGGYQFGNGWRAEGEYVFKRSGNFVSYWAPFDANANEFHVSSQRLML 125 GP ++++ GGYQ E Y + P+ + +Q + L Sbjct: 48 NGPTHENQLGAGAFGGYQVNPYVGFEMGYDWLGR-------MPYKGSVENGAYKAQGVQL 100 Query: 126 NGYRDFDLGRGFSVYGTLGVGVAIVSAEGWQGNDTRRFASKTQTNLAYS--AGAGVSYAI 183 + + +Y LG V DT+ + S GV YAI Sbjct: 101 TAKLGYPITDDLDIYTRLGGMVW--------RADTKSNVYGKNHDTGVSPVFAGGVEYAI 152 Query: 184 NKRFTIDVGYRYV-DMGNVET 203 + Y++ ++G+ T Sbjct: 153 TPEIATRLEYQWTNNIGDAHT 173
>TCRTETA#Tetracycline resistance protein signature. Length = 399 Score = 37.5 bits (87), Expect = 8e-05 Identities = 43/196 (21%), Positives = 66/196 (33%), Gaps = 13/196 (6%) Query: 21 LSMLLVATVLNYVDRSALGIVAPALSKDLALTRVQ---MGELFAVFGLAYSIALLPAGVL 77 L ++L L+ V + V P L +DL + G L A++ L G L Sbjct: 7 LIVILSTVALDAVGIGLIMPVLPGLLRDLVHSNDVTAHYGILLALYALMQFACAPVLGAL 66 Query: 78 ADMLGSRVAYALSLVGWSLATLTQGLAHGYHMLLGSRLAMGALEAPAFPSNARAVTMWFP 137 +D G R +SL G ++ A +L R+ G A + Sbjct: 67 SDRFGRRPVLLVSLAGAAVDYAIMATAPFLWVLYIGRIVAGITGAT-GAVAGAYIADITD 125 Query: 138 VQER----GFATSVYVMGQYIGTPLFTGLLLWISSAFGWRTVFFATGAFGILFSVVWYRL 193 ER GF ++ + G G P+ GL+ S FFA A L + L Sbjct: 126 GDERARHFGFMSACFGFGMVAG-PVLGGLMGGFSP----HAPFFAAAALNGLNFLTGCFL 180 Query: 194 YRDPSRHPRVNAAELQ 209 + + R Sbjct: 181 LPESHKGERRPLRREA 196
>DHBDHDRGNASE#2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase signature. Length = 261 Score = 103 bits (258), Expect = 8e-29 Identities = 61/195 (31%), Positives = 91/195 (46%), Gaps = 3/195 (1%) Query: 4 EKKIAAVTGAGTGIGQAAAVALAQAGFSVALLGRRIDPLLATQEIIELAGGVAAAIPTDV 63 E KIA +TGA GIG+A A LA G +A + + L ++ A A P DV Sbjct: 7 EGKIAFITGAAQGIGEAVARTLASQGAHIAAVDYNPEKLEKVVSSLKAEARHAEAFPADV 66 Query: 64 SDETSVDASFTRIAHDFGRLDVLFNNAGRNAGAVPLDDYSLEFWNDVVATNLTGVFLCAR 123 D ++D RI + G +D+L N AG + S E W + N TGVF +R Sbjct: 67 RDSAAIDEITARIEREMGPIDILVNVAGVLRPG-LIHSLSDEEWEATFSVNSTGVFNASR 125 Query: 124 AAWRQMKRQTPQGGRIINNGSISAHTPRPHTIAYTATKHAVLGITRSLALDGRPFNIACG 183 + + M + + G I+ GS A PR AY ++K A + T+ L L+ +NI C Sbjct: 126 SVSKYMMDR--RSGSIVTVGSNPAGVPRTSMAAYASSKAAAVMFTKCLGLELAEYNIRCN 183 Query: 184 QIDIGNAATSLTERM 198 + G+ T + + Sbjct: 184 IVSPGSTETDMQWSL 198
>TCRTETA#Tetracycline resistance protein signature. Length = 399 Score = 41.7 bits (98), Expect = 4e-06 Identities = 75/385 (19%), Positives = 127/385 (32%), Gaps = 32/385 (8%) Query: 42 VAPIIKRELGIDD---AQMGILFSSFFIGYCVFCFVGGWAADRFGPRRVFACAAGVWSLF 98 V P + R+L + A GIL + + + V G +DRFG R V + ++ Sbjct: 27 VLPGLLRDLVHSNDVTAHYGILLALYALMQFACAPVLGALSDRFGRRPVLLVSLAGAAVD 86 Query: 99 CGATALAGSFAHLLIVRVAFGIGEGPMGTTTNKAISNWFPRREAGRAVGWTNAGQPLGAA 158 A A L I R+ GI I++ E R G+ +A G Sbjct: 87 YAIMATAPFLWVLYIGRIVAGITGATGAVAGA-YIADITDGDERARHFGFMSACFGFG-M 144 Query: 159 IAAPIVGLVALQFGWRVSFVVIATLGFVWLAAWWALFRDDPASHPRVSPEEVREIASDRT 218 +A P++G + F F A L + L + SH RE + Sbjct: 145 VAGPVLGGLMGGFSPHAPFFAAAALNGLNFLTGCFLLPE---SHKGERRPLRREALNPLA 201 Query: 219 VGVSLDAHADERAARPLLRDLLSRPVLGVALAFFSFNYVLYFFLSWLPSYLTDYQHLNIK 278 V + FF V + + D H + Sbjct: 202 S---------------FRWARGMTVVAALMAVFFIMQLVGQVPAALWVIFGEDRFHWDAT 246 Query: 279 QMSVVGILPWLGATVGFVAGGTVSDRIYRRTGDVLFARKIVIVVGLAVAAACVLLASRVS 338 +GI + +A ++ + R G+ R+ +++ +A +LLA Sbjct: 247 ---TIGISLAAFGILHSLAQAMITGPVAARLGE----RRALMLGMIADGTGYILLAFATR 299 Query: 339 SLGAAVTLIAIASLFAFMAPQACWSLLQEIVPRERVGSAGGFVHLLANLAGILSPSLTGW 398 A ++ +AS P A ++L V ER G G + L +L I+ P L Sbjct: 300 GWMAFPIMVLLAS-GGIGMP-ALQAMLSRQVDEERQGQLQGSLAALTSLTSIVGPLLFTA 357 Query: 399 LVQYGGGYASAFVLAGASALAGAVI 423 + + + +AL + Sbjct: 358 IYAASITTWNGWAWIAGAALYLLCL 382
>DHBDHDRGNASE#2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase signature. Length = 261 Score = 52.4 bits (125), Expect = 3e-10 Identities = 49/218 (22%), Positives = 93/218 (42%), Gaps = 18/218 (8%) Query: 3 IQGSVALVTGANRGLGAAFTRALLTAGAAKVYAA-------AREASTVTASGVVPVRLDV 55 I+G +A +TGA +G+G A R L + G A + A + S++ A Sbjct: 6 IEGKIAFITGAAQGIGEAVARTLASQG-AHIAAVDYNPEKLEKVVSSLKAEARHAEAFPA 64 Query: 56 TRAD------QVEALARELGDVSLLVNNAGIGGSGAVLAPSSIDMLRQQFETNAVGPLRM 109 D + RE+G + +LVN AG+ G + S + F N+ G Sbjct: 65 DVRDSAAIDEITARIEREMGPIDILVNVAGVLRPGL-IHSLSDEEWEATFSVNSTGVFNA 123 Query: 110 AQAFAPILAASGSSAMINVISALSWATLPGIT-GSYSASKAAAWALSNAMRQELSAQGTE 168 +++ + + S +++ V S + A +P + +Y++SKAAA + + EL+ Sbjct: 124 SRSVSKYMMDRRSGSIVTVGS--NPAGVPRTSMAAYASSKAAAVMFTKCLGLELAEYNIR 181 Query: 169 VLSLHVAFMDTDMARGVPGPKASPDEVARMALAALEAG 206 + +TDM + + ++V + +L + G Sbjct: 182 CNIVSPGSTETDMQWSLWADENGAEQVIKGSLETFKTG 219
>DHBDHDRGNASE#2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase signature. Length = 261 Score = 78.2 bits (192), Expect = 4e-19 Identities = 48/188 (25%), Positives = 83/188 (44%), Gaps = 8/188 (4%) Query: 3 KTILITGASSGFGLMLANKLHKDGFNVIGTSRQPEKYARNVPFKL--------LRLDIDD 54 K ITGA+ G G +A L G ++ PEK + V D+ D Sbjct: 9 KIAFITGAAQGIGEAVARTLASQGAHIAAVDYNPEKLEKVVSSLKAEARHAEAFPADVRD 68 Query: 55 DTSIESFTHELFTYTKQLDVLVNNAGYMVTGIAEETPLEVGRQQFETNFWGTVKVTNALL 114 +I+ T + +D+LVN AG + G+ E F N G + ++ Sbjct: 69 SAAIDEITARIEREMGPIDILVNVAGVLRPGLIHSLSDEEWEATFSVNSTGVFNASRSVS 128 Query: 115 PFFRKQKSGQIITVSSIVGLIGPPNLSYYSASKHAVEGYFKALRFELNQFNIKVSVVEPV 174 + ++SG I+TV S + +++ Y++SK A + K L EL ++NI+ ++V P Sbjct: 129 KYMMDRRSGSIVTVGSNPAGVPRTSMAAYASSKAAAVMFTKCLGLELAEYNIRCNIVSPG 188 Query: 175 WFKTNLGQ 182 +T++ Sbjct: 189 STETDMQW 196
>DHBDHDRGNASE#2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase signature. Length = 261 Score = 119 bits (300), Expect = 8e-35 Identities = 74/254 (29%), Positives = 122/254 (48%), Gaps = 5/254 (1%) Query: 2 ARKLDNKIALVTGATSGIGLATAQRFAAEGAHVYLTGRRQVELDAAVKGIREAGGNATGV 61 A+ ++ KIA +TGA GIG A A+ A++GAH+ +L+ V ++ +A Sbjct: 3 AKGIEGKIAFITGAAQGIGEAVARTLASQGAHIAAVDYNPEKLEKVVSSLKAEARHAEAF 62 Query: 62 RSDSTQLDELDALYAQIKEEQGRLDVLFVNAGGGSMLPLGNITEAHYDDTFDRNVKGVLF 121 +D +D + A+I+ E G +D+L AG + ++++ ++ TF N GV Sbjct: 63 PADVRDSAAIDEITARIEREMGPIDILVNVAGVLRPGLIHSLSDEEWEATFSVNSTGVFN 122 Query: 122 TVQKALPLLA--EGASVILTGSTAGSAGTAAFSVYSASKAAVRAFARSWILDLKERRVRV 179 + + S++ GS + + Y++SKAA F + L+L E +R Sbjct: 123 ASRSVSKYMMDRRSGSIVTVGSNPAGVPRTSMAAYASSKAAAVMFTKCLGLELAEYNIRC 182 Query: 180 NTISPGATRTPGLLDLAGDDATQRQGLADYLASL---IPMGRLGEPEEIAGAALFLASDD 236 N +SPG+T T L D+ Q + L + IP+ +L +P +IA A LFL S Sbjct: 183 NIVSPGSTETDMQWSLWADENGAEQVIKGSLETFKTGIPLKKLAKPSDIADAVLFLVSGQ 242 Query: 237 ASFVNGIELFVDGG 250 A + L VDGG Sbjct: 243 AGHITMHNLCVDGG 256
>AEROLYSIN#Aerolysin signature. Length = 493 Score = 26.9 bits (59), Expect = 0.010 Identities = 18/55 (32%), Positives = 31/55 (56%), Gaps = 7/55 (12%) Query: 1 MKQIIVTAGLALLASAPLTSFAQSDMPLSRAQVRAELANLEQ----AGYNPLSVD 51 M++I +T GL+L+ S L + AQ+ P+ Q+R L +L Q Y P++ + Sbjct: 1 MQKIKLT-GLSLIISGLLMAQAQAAEPVYPDQLR--LFSLGQGVCGDKYRPVNRE 52
>TCRTETA#Tetracycline resistance protein signature. Length = 399 Score = 56.4 bits (136), Expect = 1e-10 Identities = 45/168 (26%), Positives = 71/168 (42%), Gaps = 10/168 (5%) Query: 59 AFDALSLAFVLPVLIGL---WHLS---AGQIGVLIAAGYLGQVVGALVFGWLAERIGRVP 112 A DA+ + ++PVL GL S G+L+A L Q A V G L++R GR P Sbjct: 15 ALDAVGIGLIMPVLPGLLRDLVHSNDVTAHYGILLALYALMQFACAPVLGALSDRFGRRP 74 Query: 113 SATVTVGVMSAMSIVCAFTGSFHMLFLMRFLQGIGVGGEVPVAATYINELSQAHGRGRFF 172 V++ + + A +L++ R + GI G VA YI +++ R R F Sbjct: 75 VLLVSLAGAAVDYAIMATAPFLWVLYIGRIVAGI-TGATGAVAGAYIADITDGDERARHF 133 Query: 173 ILYELIFPLGLLAAAQLGAF---IVPRFGWEYMFLVGGIPGIIVAFLI 217 F G++A LG P + + G+ + FL+ Sbjct: 134 GFMSACFGFGMVAGPVLGGLMGGFSPHAPFFAAAALNGLNFLTGCFLL 181
>ECOLNEIPORIN#E.coli/Neisseria porin superfamily signature. Length = 331 Score = 70.2 bits (172), Expect = 1e-15 Identities = 75/366 (20%), Positives = 128/366 (34%), Gaps = 56/366 (15%) Query: 13 MRKVAGTLGVAAMLSAGLALTSVGARADSGSQVQLYGIV--GTYVGSVKRSDTPQSTVLI 70 M+K L +AA+ A +A V LYG + G + Q+ + Sbjct: 1 MKKSLIALTLAALPVAAMA------------DVTLYGTIKAGVETSRSVAHNGAQAASVE 48 Query: 71 GSGGLTT--SFWGIRGKEDLGGGVSAIFALESFFQPQNGAQGRNATDPFFSRNAYVGFQG 128 G+ S G +G+EDLG G+ AI+ +E + G ++ + +R +++G +G Sbjct: 49 TGTGIVDLGSKIGFKGQEDLGNGLKAIWQVEQ----KASIAGTDSG--WGNRQSFIGLKG 102 Query: 129 DFGQLTFGRQRNPTYTAESLINPFSSSTVFSPLVLQTFVTNYGGTIIGDTVWNNTAKYTT 188 FG+L GR + + S S I + +Y + Sbjct: 103 GFGKLRVGRLNSVLKDTGDINPWDSKSDYLG-----------VNKIAEPEARLISVRYDS 151 Query: 189 PDFKGFGATVIYGLGGVAGSPGVGNLGAHLNYQGHGLTAVVSGQRVRY---TAAGPVGAQ 245 P+F G +V Y L AG + A NY+ G G R+ + Sbjct: 152 PEFAGLSGSVQYALNDNAGRHNSESYHAGFNYKNGGFFVQYGGAYKRHHQVQENVNIEKY 211 Query: 246 YAYLAGAAYDFKLVTLYGAWAMTSDVSTP-TGSHTYEAGFSIPFTPA-DFLLAEWARTQR 303 + + YD LY + A+ + ++++ + + T A F T R Sbjct: 212 QIHRLVSGYDND--ALYASVAVQQQDAKLVEENYSHNSQTEVAATLAYRFGNV----TPR 265 Query: 304 SGPTHT---------TNSLRNTAALGYDHLLSKRTDIYAIYSI---DKLSDHPIGNTFAV 351 H N+ + +G ++ SKRT K + V Sbjct: 266 VSYAHGFKGSFDATNYNNDYDQVVVGAEYDFSKRTSALVSAGWLQEGKGESKFVSTAGGV 325 Query: 352 GIRHTF 357 G+RH F Sbjct: 326 GLRHKF 331
>ECOLNEIPORIN#E.coli/Neisseria porin superfamily signature. Length = 331 Score = 100 bits (251), Expect = 5e-26 Identities = 93/377 (24%), Positives = 134/377 (35%), Gaps = 64/377 (16%) Query: 1 MKTKKIEIIVGSLVGLASSVAHSQSSVTLYGEIDNGIHYQTNVGG----GKAVYMDSLDG 56 MK I + + +L + + VTLYG I G+ +V +V + Sbjct: 1 MKKSLIALTLAALP------VAAMADVTLYGTIKAGVETSRSVAHNGAQAASVETGTGIV 54 Query: 57 IDGSRWGLTGKEDLGGGLKAIFTLESGINVNNGQFAQGGTAFGRQAFVGLSSDTYGSLTA 116 GS+ G G+EDLG GLKAI+ +E ++ G RQ+F+GL +G L Sbjct: 55 DLGSKIGFKGQEDLGNGLKAIWQVEQKASIAGTDSGWG----NRQSFIGLKGG-FGKLRV 109 Query: 117 GRQYDMVWYFPEFLA---GSAAVGDLPSAHPGDFDNTSNSVRFNNSVRYMSPDFRGFSFG 173 GR ++ + S +G A P SVRY SP+F G S Sbjct: 110 GRLNSVLKDTGDINPWDSKSDYLGVNKIAEPEA---------RLISVRYDSPEFAGLSGS 160 Query: 174 VEYSLGGVPGDFTSMSGYSLGVGYTHGPLQIGAAFDYFKHPTSTPGNGWFTNYASGFNLL 233 V+Y+L G S Y G Y +G + Y +H Sbjct: 161 VQYALNDNAGRHNS-ESYHAGFNYKNGGFFVQYGGAYKRHHQVQENVN-------IEKYQ 212 Query: 234 ASSLNSAYQVAQAYQDAVIAAAYT-IGNAT-ISASYSNVQYANLGAGFMNGTAVFNNYDI 291 L S Y DA+ A+ +A + +YS+ A Y Sbjct: 213 IHRLVSGYD-----NDALYASVAVQQQDAKLVEENYSHNS--------QTEVAATLAYRF 259 Query: 292 G-LNYRVTPVFFVGVAYDYMNARSVTTAQGNAVGNQHYNQVAFTLDYLLSKRTDVYFSGG 350 G + RV+ ++D N N Y+QV +Y SKRT S G Sbjct: 260 GNVTPRVSYAHGFKGSFDATN------------YNNDYDQVVVGAEYDFSKRTSALVSAG 307 Query: 351 W-QRASGTSSTGAPAVA 366 W Q G S + A Sbjct: 308 WLQEGKGESKFVSTAGG 324
>TCRTETA#Tetracycline resistance protein signature. Length = 399 Score = 30.6 bits (69), Expect = 0.013 Identities = 29/144 (20%), Positives = 50/144 (34%), Gaps = 17/144 (11%) Query: 58 AVFGAIFSAVFFGLLIGNFGIPFATRRFSTKKIAFVATAAFGLFTVLTVFATSVPQLIAL 117 + ++ A+ G + R ++ + A G +L FAT + Sbjct: 256 GILHSLAQAMITGPV---------AARLGERRALMLGMIADGTGYILLAFATRGWMAFPI 306 Query: 118 RFLT---GIGLGAATPCAVGLVSEFSPKRTRATFVILVYMGYALGFIFAGICSSALIPRF 174 L GIG+ A V E + + + L + +G + +A I Sbjct: 307 MVLLASGGIGMPALQAMLSRQVDEERQGQLQGSLAALTSLTSIVGPLLFTAIYAASITT- 365 Query: 175 GWEGPLWLGGLAAVGLTVLLVPLL 198 W G W+ G A L +L +P L Sbjct: 366 -WNGWAWIAGAA---LYLLCLPAL 385
>RTXTOXIND#Gram-negative bacterial RTX secretion protein D signature. Length = 478 Score = 29.8 bits (67), Expect = 0.023 Identities = 10/37 (27%), Positives = 19/37 (51%) Query: 57 VPSPTAGVIKEMKVAVGETVSQGTLIALLDSDGERQD 93 + ++KE+ V GE+V +G ++ L + G D Sbjct: 99 IKPIENSIVKEIIVKEGESVRKGDVLLKLTALGAEAD 135
>PF06776#Invasion associated locus B Length = 214 Score = 29.5 bits (66), Expect = 0.026 Identities = 8/34 (23%), Positives = 13/34 (38%) Query: 91 PAKPVAAAAPAAAPAQAAAAAAAAPAPQAGSYGG 124 A+ + A A A A + + A A +G Sbjct: 49 GARLMLAGAMAIALSFGWSDRADAQGAVRSVHGD 82
>HTHTETR#TetR bacterial regulatory protein HTH signature. Length = 215 Score = 71.6 bits (175), Expect = 9e-18 Identities = 29/173 (16%), Positives = 57/173 (32%), Gaps = 6/173 (3%) Query: 2 AVGTRDALVQAAEGLMRSRGYAAFSYADLAETVGIRKASIHHHFPTKEDLGVAIVEAYVA 61 A TR ++ A L +G ++ S ++A+ G+ + +I+ HF K DL I E + Sbjct: 9 AQETRQHILDVALRLFSQQGVSSTSLGEIAKAAGVTRGAIYWHFKDKSDLFSEIWELSES 68 Query: 62 RVVEAF-ERIDRENEDFWGRL-NGFFDTFRASSDGSLLPL---CGALAAEMAALPPELQK 116 + E E + D L ++ L E +Q+ Sbjct: 69 NIGELELEYQAKFPGDPLSVLREILIHVLESTVTEERRRLLMEIIFHKCEFVGEMAVVQQ 128 Query: 117 LTHRFFELQLRWLTRVIDKGISDGEIAAGVGSCQKAYQVLSVLEGASFVEWAM 169 + + + I + A + + + A + + G W Sbjct: 129 AQRNLCLESYDRIEQTLKHCIEAKMLPADLMTRRAAIIMRGYISGL-MENWLF 180
>DHBDHDRGNASE#2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase signature. Length = 261 Score = 102 bits (254), Expect = 4e-28 Identities = 66/251 (26%), Positives = 113/251 (45%), Gaps = 8/251 (3%) Query: 6 GKKLLVVGGTSGIGLATAKQVLKSGGSVVLTGNRKDKAEAVRAELSGLGPVS-VIAANLM 64 GK + G GIG A A+ + G + +K E V + L + A++ Sbjct: 8 GKIAFITGAAQGIGEAVARTLASQGAHIAAVDYNPEKLEKVVSSLKAEARHAEAFPADVR 67 Query: 65 TEEGMNAIRSEINANHKDISLLVNSAGIFAPKAFIDHEESDYDMYLSLNRATFFITRDVV 124 ++ I + I I +LVN AG+ P + +++ S+N F V Sbjct: 68 DSAAIDEITARIEREMGPIDILVNVAGVLRPGLIHSLSDEEWEATFSVNSTGVFNASRSV 127 Query: 125 RNMLAAKLQGAIVNVGSIGAQAALGDSAASAYSMAKAGLHALTRNLAIELADAGIRVNAV 184 + + G+IV VGS A ++ +AY+ +KA T+ L +ELA+ IR N V Sbjct: 128 SKYMMDRRSGSIVTVGSNPAGVP--RTSMAAYASSKAAAVMFTKCLGLELAEYNIRCNIV 185 Query: 185 SPAIVQTSIYEGFMAKED-----IAGAMKALESFHPLGRVGTPEDVANTIVFLLSDKTSW 239 SP +T + A E+ I G+++ ++ PL ++ P D+A+ ++FL+S + Sbjct: 186 SPGSTETDMQWSLWADENGAEQVIKGSLETFKTGIPLKKLAKPSDIADAVLFLVSGQAGH 245 Query: 240 VTGAIWNVDAG 250 +T VD G Sbjct: 246 ITMHNLCVDGG 256
>TCRTETA#Tetracycline resistance protein signature. Length = 399 Score = 71.0 bits (174), Expect = 1e-15 Identities = 99/394 (25%), Positives = 158/394 (40%), Gaps = 31/394 (7%) Query: 26 VLLLGSSLTVMGAVMIAPILPKLAADFVPANPRLAALVPLVATGPALAIALCAPLAGWLA 85 V+L +L +G +I P+LP L D V +N A L+A AL CAP+ G L+ Sbjct: 9 VILSTVALDAVGIGLIMPVLPGLLRDLVHSNDVTAHYGILLALY-ALMQFACAPVLGALS 67 Query: 86 DRVGRKMLLLL----ATLVYGLVGAAPAWLDSFTAILVCRFALGAAEACVMTCCTTLIGD 141 DR GR+ +LL+ A + Y ++ AP + + R G A I D Sbjct: 68 DRFGRRPVLLVSLAGAAVDYAIMATAPF----LWVLYIGRIVAGITGA-TGAVAGAYIAD 122 Query: 142 YWHGEQRVRYVNRQVVTIGVVGTIFFVLGGAAGEHAWRYPFYLY-LLPILLIPAIAALLW 200 G++R R+ G VLGG G + PF+ L L LL Sbjct: 123 ITDGDERARHFGFMSACFGFGMVAGPVLGGLMGGFSPHAPFFAAAALNGLNFLTGCFLLP 182 Query: 201 EPLRHGRPAEPGDGGTPLSGGKLASTLAIGYLLICVGMVSSFVVPVQMPQLM-----IDI 255 E + R + PL+ + A + + L+ V + + Q+P + D Sbjct: 183 ESHKGERRPLRREALNPLASFRWARGMTVVAALMAVFFIMQ--LVGQVPAALWVIFGEDR 240 Query: 256 GQHSSTMIG-AVSGIGLLSTLAGSIAWPWLRDSLGRRFVNVALLVLLAVGLYLLASANTV 314 +T IG +++ G+L +LA ++ + LG R + ++ G LLA A Sbjct: 241 FHWDATTIGISLAAFGILHSLAQAMITGPVAARLGERRALMLGMIADGTGYILLAFATRG 300 Query: 315 PAIVVAVVIHGFGGGMLVPNAILPLMRRLSLAIRGRALGGFTAALYLGQFLSPLVVLGCA 374 +V+ GG+ +P L R++ +G+ G A L + PL+ Sbjct: 301 WMAFPIMVLLA-SGGIGMPALQAMLSRQVDEERQGQLQGSLAALTSLTSIVGPLL----- 354 Query: 375 QAFGGLRPAIVSIASGTA----ATALLWLLPAFR 404 F + A ++ +G A A L LPA R Sbjct: 355 --FTAIYAASITTWNGWAWIAGAALYLLCLPALR 386
>TATBPROTEIN#Bacterial sec-independent translocation TatB protein signature. Length = 171 Score = 28.8 bits (64), Expect = 0.018 Identities = 11/42 (26%), Positives = 21/42 (50%) Query: 89 VHLVPVLSLTRREGHTIEELKAAAEDLQRAQPAANPLGRPVA 130 V + +LT +++EL+ AAE ++R+ A +P Sbjct: 66 VEKASLTNLTPELKASMDELRQAAESMKRSYVANDPEKASDE 107
>SACTRNSFRASE#Streptothricin acetyltransferase signature. Length = 173 Score = 31.8 bits (72), Expect = 6e-04 Identities = 15/52 (28%), Positives = 26/52 (50%) Query: 93 LAVDQAYRGRRLGAALLVNALQRAAKSEIAAVALTVDAKDETAAAFYRHFGF 144 +AV + YR + +G ALL A++ A ++ + L + +A FY F Sbjct: 95 IAVAKDYRKKGVGTALLHKAIEWAKENHFCGLMLETQDINISACHFYAKHHF 146
>DNABINDNGFIS#DNA-binding protein FIS signature. Length = 98 Score = 28.0 bits (62), Expect = 0.020 Identities = 12/29 (41%), Positives = 16/29 (55%) Query: 8 MYHETGNAGLVCTRCGISRPTLRKWLRRY 36 M + GN GI+R TLRK L++Y Sbjct: 67 MQYTRGNQTRAALMMGINRGTLRKKLKKY 95
>PF04335#VirB8 type IV secretion protein Length = 227 Score = 192 bits (489), Expect = 1e-63 Identities = 51/220 (23%), Positives = 85/220 (38%), Gaps = 9/220 (4%) Query: 4 QSDYRRALDFEASLTALQACSERRAWQVAFAAVIVAIGSVAALAVMMPFYRVVPLPIEVN 63 ++ + A +E A S++ AW VA A +A V A+A + P V P I V+ Sbjct: 11 KAYFEEAASWERDKLAAAERSKKLAWVVAGVAGALATAGVVAVAALTPLKTVEPYVITVD 70 Query: 64 KLTGEAQFIEVLDA-KHVPLREIEDKHWVEVYVRTRERYDWGLLQMDYDRVLDMSDESVA 122 + TGEA L + E K+++ YVR RE + + +D V+ MS Sbjct: 71 RNTGEASIAAKLHGDATITYDEAVRKYFLATYVRYREGWIAAAREEYFDAVMVMSARPEQ 130 Query: 123 RAYRQIYSG--PNALDQQLGASVQYRTRIVSTTLVPDEPGHAVVHLERTVRKNGIDTGEP 180 + + Y P + L I + + A V+ + + Sbjct: 131 DRWSRFYKTDNPQSPQNILANRTDVFVEIKRVSFLGGNV--AQVYFTKESVT---GSNST 185 Query: 181 AKRFVITLAFTYRPTVLVRERSAIENPFGFKVTAYSRDAE 220 V T+ + T +E +NP G++V +Y D E Sbjct: 186 KTDAVATIKYKVDGTPS-KEVDRFKNPLGYQVESYRADVE 224
>TYPE4SSCAGX#Type IV secretion system CagX conjugation protein signature. Length = 522 Score = 44.0 bits (103), Expect = 3e-07 Identities = 45/192 (23%), Positives = 68/192 (35%), Gaps = 55/192 (28%) Query: 83 DHDVYLKPKLAAHDTNLIVRTDRRSYSFDLLV----------LPLKARFGNAHEMYRV-- 130 D+ + L P +A TNL+VRT++ Y F L + L +K + HE+ V Sbjct: 265 DNSIELSPSDSAWRTNLVVRTNKALYQFILRIAQKDNFASAYLTVKLEYPQRHEVSSVIE 324 Query: 131 ------------------------SFVYPDTAASDASI-------------------AAR 147 +++ AS+ I A Sbjct: 325 EELKKREEAKRQRELIKQENLNTTAYINRVMMASNEQIINKEKIREEKQKIILDQAKALE 384 Query: 148 LACLQKRLSQPSVVRNAAYSMQVMPHAEDIAPSAVWDDGRFTYIRIPNNRRIPAIFRIED 207 + L + V RN Y ++ I PS ++DDG FTY N PAIF ++ Sbjct: 385 TQYVHNALKRNPVPRNYNYYQAPEKRSKHIMPSEIFDDGTFTYFGFKNITLQPAIFVVQP 444 Query: 208 DDTERVVDKHID 219 D + D ID Sbjct: 445 DGKLSMTDAAID 456
>ECOLNEIPORIN#E.coli/Neisseria porin superfamily signature. Length = 331 Score = 71.4 bits (175), Expect = 5e-16 Identities = 80/354 (22%), Positives = 132/354 (37%), Gaps = 53/354 (14%) Query: 1 MKLRLGVLAMLAVAQGAWAQSSVTMFGLIDSGITYVSNEG--GGKNVKFDDGIFAPNL-- 56 MK L +A+ A A + VT++G I +G+ + G + + G +L Sbjct: 1 MKKSL--IALTLAALPVAAMADVTLYGTIKAGVETSRSVAHNGAQAASVETGTGIVDLGS 58 Query: 57 -FGLRGTEDLGGGYRATFALVNQFSMANGSIVGTGIFGRNAYVGIESDRFGSITLGNQYD 115 G +G EDLG G +A + + + S+A +G R +++G++ FG + +G Sbjct: 59 KIGFKGQEDLGNGLKAIWQVEQKASIAGT---DSGWGNRQSFIGLKGG-FGKLRVGRLNS 114 Query: 116 FMVDALFSRGNAISRDISGLYGFRNGPFQRLALPGNPTGAFDWDRTAGSKPIANSVKYSS 175 + D DI+ + ++ A + SV+Y S Sbjct: 115 VLKDTG---------DINPW--DSKSDY------------LGVNKIAEPEARLISVRYDS 151 Query: 176 PTVAGFSGGVMYAFGGVAGSVGADNAVSAGVNYELGAFGV--GAAYTNEKYGPAPGVPST 233 P AG SG V YA AG ++ + AG NY+ G F V G AY V Sbjct: 152 PEFAGLSGSVQYALNDNAGRHNSE-SYHAGFNYKNGGFFVQYGGAYKRHHQV-QENVNIE 209 Query: 234 SVRNWGVGMHYDFGVVTAKA-----LMTTVRNSFNDAGVWMAEAGGLWR---IRPDIVLG 285 + + YD + A V +++ A +R + P + Sbjct: 210 KYQIHRLVSGYDNDALYASVAVQQQDAKLVEENYSHNSQTEVAATLAYRFGNVTPRV--- 266 Query: 286 AKYMYMKG---NEAVNDNHAHQISVALQYLLSKRTMVYVSADCQRANGGANAQV 336 Y + + +N Q+ V +Y SKRT VSA + G + V Sbjct: 267 -SYAHGFKGSFDATNYNNDYDQVVVGAEYDFSKRTSALVSAGWLQEGKGESKFV 319
>HTHFIS#FIS bacterial regulatory protein HTH signature. Length = 484 Score = 75.6 bits (186), Expect = 5e-18 Identities = 36/164 (21%), Positives = 69/164 (42%), Gaps = 7/164 (4%) Query: 2 PRVAIVEDHERLAGLLSQALAAAGIESDRFGNAREAAYGVDRADYALLIIDRGLPDGDGL 61 + + +D + +L+QAL+ AG + NA + D L++ D +PD + Sbjct: 4 ATILVADDDAAIRTVLNQALSRAGYDVRITSNAATLWRWIAAGDGDLVVTDVVMPDENAF 63 Query: 62 AFLRTLRAAGRMMPCLMLTARDALHDRIDGLESGADDYVTKPFEMSELVARVRTLM---- 117 L ++ A +P L+++A++ I E GA DY+ KPF+++EL+ + + Sbjct: 64 DLLPRIKKARPDLPVLVMSAQNTFMTAIKASEKGAYDYLPKPFDLTELIGIIGRALAEPK 123 Query: 118 -RRPALLTTLVASFADVTVDPPQRAMRCGDRTVLLAPAELQIML 160 R L V + + L +L +M+ Sbjct: 124 RRPSKLEDDSQDGMPLVGRSAAMQEIY--RVLARLMQTDLTLMI 165
>BLACTAMASEA#Beta-lactamase class A signature. Length = 286 Score = 28.6 bits (64), Expect = 0.048 Identities = 18/72 (25%), Positives = 28/72 (38%), Gaps = 3/72 (4%) Query: 67 ADRESRTPMREDTLFRLASVTKPIVSAAAMALVAQRKLSLDEDI---ARWLPDFRPALPD 123 A + T R D F + S K ++ A +A V L+ I + L D+ P Sbjct: 48 ASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEK 107 Query: 124 GRVPTITVRQLL 135 +TV +L Sbjct: 108 HLADGMTVGELC 119
>HTHTETR#TetR bacterial regulatory protein HTH signature. Length = 215 Score = 55.4 bits (133), Expect = 7e-12 Identities = 30/140 (21%), Positives = 50/140 (35%), Gaps = 4/140 (2%) Query: 6 SSNSRERILAAATRLAQTHGYGGLNYRDLASEVGIKAASIYHHFESKADLGAAVARRYWE 65 + +R+ IL A RL G + ++A G+ +IY HF+ K+DL + + Sbjct: 9 AQETRQHILDVALRLFSQQGVSSTSLGEIAKAAGVTRGAIYWHFKDKSDLFSEIWELSES 68 Query: 66 DSAAALDDMLAN-SRDPLDCLRRYPDTFRKALETGNRLCL---CSFMAAETDDLPEVVMK 121 + + A DPL LR ++ T R L F E VV + Sbjct: 69 NIGELELEYQAKFPGDPLSVLREILIHVLESTVTEERRRLLMEIIFHKCEFVGEMAVVQQ 128 Query: 122 EVLAFADVNVAWLSKALSAA 141 + + + L Sbjct: 129 AQRNLCLESYDRIEQTLKHC 148
>PF05043#Transcriptional activator Length = 493 Score = 31.5 bits (71), Expect = 0.005 Identities = 15/55 (27%), Positives = 31/55 (56%) Query: 22 KIRHLVLLLQIQQHGSLTRVAEHMASSQPAVTNALSELESMFGTPLFERSSRGMR 76 ++ L LL + ++ + +AE + ++ AV + LS ++S F +F S+ G+R Sbjct: 12 QLELLELLFEHKRWFHRSELAELLNCTERAVKDDLSHVKSAFPDLIFHSSTNGIR 66
>ECOLNEIPORIN#E.coli/Neisseria porin superfamily signature. Length = 331 Score = 97.6 bits (243), Expect = 6e-25 Identities = 80/388 (20%), Positives = 137/388 (35%), Gaps = 70/388 (18%) Query: 1 MKKAVVGTLSLAFVSAVAHAQSSVTLYGMLDAGIAYTNNQSGKHAWQQGSGLLSNTV--- 57 MKK++ ++L + A + VTLYG + AG+ + + + A + V Sbjct: 1 MKKSL---IALTLAALPVAAMADVTLYGTIKAGVETSRSVAHNGAQAASVETGTGIVDLG 57 Query: 58 --FGLSGNEDLGGGLHALFRLESGFNLNNGMQSYRNTLFGRRAYVGLQSDQYGTLTLGRQ 115 G G EDLG GL A++++E ++ + N R++++GL+ +G L +GR Sbjct: 58 SKIGFKGQEDLGNGLKAIWQVEQKASIAGTDSGWGN----RQSFIGLKGG-FGKLRVGRL 112 Query: 116 YDAVVDYLGPLAMANNGD---GNNLASHPFDNDNLDDSFYIDNAVKYASPTLAGWQFGGL 172 + D + D N +A ++ I +V+Y SP AG Sbjct: 113 NSVLKDTGDINPWDSKSDYLGVNKIAEP--------EARLI--SVRYDSPEFAGLSGSVQ 162 Query: 173 YGFGNAAGGFANNRAYSAGVSYANGPVSLGAAYLQLNRGGLTTGGALSANDAPNFPAVRQ 232 Y + A G N+ +Y AG +Y NG + + + Sbjct: 163 YALNDNA-GRHNSESYHAGFNYKNGGFFVQYGGAYKRHHQVQENV----------NIEKY 211 Query: 233 RVMGAGGSYAFDRLTIGALWTHTMFDETAASSLPGALNALRFDNYEVNARYA-----LTP 287 ++ Y D L ++ + + N EV A A +TP Sbjct: 212 QIHRLVSGYDNDALYA------SVAVQQQDAK-LVEENYSHNSQTEVAATLAYRFGNVTP 264 Query: 288 AVSFTGAYTFTDGRYDDATDSHRPKWHQATLMADYALSKRTDAYAETVYQHAFGVPSGAT 347 VS+ + + + D + Q + A+Y SKRT A + Sbjct: 265 RVSYAHGFKGSFDATNYNND-----YDQVVVGAEYDFSKRTSALVSAGWLQ--------- 310 Query: 348 LGFANVTGLAASSTRTQVVATVGIRHRF 375 S VG+RH+F Sbjct: 311 -------EGKGESKFVSTAGGVGLRHKF 331
>FLGMOTORFLIG#Flagellar motor switch protein FliG signature. Length = 344 Score = 32.1 bits (73), Expect = 0.003 Identities = 21/83 (25%), Positives = 47/83 (56%), Gaps = 9/83 (10%) Query: 318 LEDLVWIDQRTLFDVISAFDTYDLAKLIANLDDRAVADKLFSVMTEARRNEVSWVMRREL 377 ED+V +D R++ V+ D +LAK + ++D V +K+F M++ + +++ ++ Sbjct: 247 FEDIVLLDDRSIQRVLREIDGQELAKALKSVDI-PVQEKIFKNMSKRAAS----MLKEDM 301 Query: 378 K-LDPVEIEDIE---QRVLEAVR 396 + L P +D+E Q+++ +R Sbjct: 302 EFLGPTRRKDVEESQQKIVSLIR 324
>OMPADOMAIN#OMPA domain signature. Length = 346 Score = 61.9 bits (150), Expect = 2e-13 Identities = 37/122 (30%), Positives = 56/122 (45%), Gaps = 15/122 (12%) Query: 111 IDAKILFNVGDARLLPHSSPVLNQIAQALSEH--ATGDILVEGHTDSVPIANAKYESNWE 168 + + +LFN A L P L+Q+ LS G ++V G+TD I + Y N Sbjct: 217 LKSDVLFNFNKATLKPEGQAALDQLYSQLSNLDPKDGSVVVLGYTDR--IGSDAY--NQG 272 Query: 169 LSSARAGSVVRYLTERGVAPHRLAAIGRADTQPLVAGDDAGSRAR---------NRRVTI 219 LS RA SVV YL +G+ +++A G ++ P+ + R +RRV I Sbjct: 273 LSERRAQSVVDYLISKGIPADKISARGMGESNPVTGNTCDNVKQRAALIDCLAPDRRVEI 332 Query: 220 FV 221 V Sbjct: 333 EV 334
>HTHFIS#FIS bacterial regulatory protein HTH signature. Length = 484 Score = 48.3 bits (115), Expect = 3e-08 Identities = 18/105 (17%), Positives = 42/105 (40%), Gaps = 15/105 (14%) Query: 2 IKILIVEDETEKRRLLIETLIEVEGVALDQITYVDDALSAKKQISARRFDLLILDINIPP 61 IL+ +D+ R +L + L D +A + + I+A DL++ D+ +P Sbjct: 4 ATILVADDDAAIRTVLNQAL---SRAGYDVRI-TSNAATLWRWIAAGDGDLVVTDVVMPD 59 Query: 62 RADKPTETGAGLEVMSFVRNNNNAIPPGCIIGMTAYDDGAEAAEE 106 +++ ++ +P ++ M+A + A + Sbjct: 60 --------ENAFDLLPRIKKARPDLP---VLVMSAQNTFMTAIKA 93
>HTHFIS#FIS bacterial regulatory protein HTH signature. Length = 484 Score = 41.7 bits (98), Expect = 3e-07 Identities = 15/94 (15%), Positives = 36/94 (38%), Gaps = 16/94 (17%) Query: 2 KIYVIEDNQLKADLICAYLQEHFTDASIRLYGSFQTGLKAIETTCPDIVLLDMNLPTFDR 61 I V +D+ ++ L +R+ + T + I D+V+ D+ +P + Sbjct: 5 TILVADDDAAIRTVLNQALS--RAGYDVRITSNAATLWRWIAAGDGDLVVTDVVMPDEN- 61 Query: 62 GPNVREGRNRPLGGYDLMRKLRLRDISTRVVVIT 95 +DL+ +++ V+V++ Sbjct: 62 -------------AFDLLPRIKKARPDLPVLVMS 82
>TCRTETA#Tetracycline resistance protein signature. Length = 399 Score = 49.8 bits (119), Expect = 1e-08 Identities = 48/286 (16%), Positives = 98/286 (34%), Gaps = 30/286 (10%) Query: 82 VLGVYADKVGRKAALSLTILLMAAGTALIGIAPTYEQAGIAAPLMIVVARLLQGFSAGGE 141 VLG +D+ GR+ L +++ A A++ AP ++ + R++ G + G Sbjct: 62 VLGALSDRFGRRPVLLVSLAGAAVDYAIMATAPFLW--------VLYIGRIVAGIT-GAT 112 Query: 142 MGGATAFLTEYAPPEKRAYYSSWIQSSIGFAVLLGAATGTFVTTSLDTQALHSWGWRLPF 201 A A++ + ++RA + ++ + GF ++ G G + + PF Sbjct: 113 GAVAGAYIADITDGDERARHFGFMSACFGFGMVAGPVLGGL---------MGGFSPHAPF 163 Query: 202 ----LLGIIVGPVGYFI--RSHIDETPAFSAVESQAKESSPLKEVLHTYPRETFASFSMV 255 L + G F+ SH E S + F M Sbjct: 164 FAAAALNGLNFLTGCFLLPESHKGERRPLRREALNPLASFRWARGMTVVAALMAVFFIMQ 223 Query: 256 ILWTVCTYVLLFYMPTYSVRTLHL-PQSTGFTAGMVGGLMIMCCSPIVGRLADAWGRRVF 314 ++ V + + + H + G + G L + + I G +A G R Sbjct: 224 LVGQVPAALWVI----FGEDRFHWDATTIGISLAAFGILHSLAQAMITGPVAARLGERRA 279 Query: 315 LSGSALAILVLAWPMFSWINHAPGFASLIVFQAVFGVLIATYTGPI 360 L +A + + ++ ++V A G+ + + Sbjct: 280 LMLGMIAD-GTGYILLAFATRGWMAFPIMVLLASGGIGMPALQAML 324 Score = 29.0 bits (65), Expect = 0.042 Identities = 16/45 (35%), Positives = 27/45 (60%), Gaps = 4/45 (8%) Query: 293 LMIMCCSPIVGRLADAWGRRVF----LSGSALAILVLAWPMFSWI 333 LM C+P++G L+D +GRR L+G+A+ ++A F W+ Sbjct: 54 LMQFACAPVLGALSDRFGRRPVLLVSLAGAAVDYAIMATAPFLWV 98
>PF08280#M protein trans-acting positive regulator Length = 530 Score = 29.4 bits (66), Expect = 0.021 Identities = 16/68 (23%), Positives = 22/68 (32%), Gaps = 15/68 (22%) Query: 9 LQCLVAF-EAAVRHASFTKAAAELHLTQSAISRQIQQLEEFLGRSLFVREHRSLRL---- 63 LQ L + T A L+ S+ R + L L R+ L Sbjct: 122 LQLLAFLIKNGSHSRPLTDFARSHFLSNSSAYRMREALIPLL---------RNFELKLSK 172 Query: 64 -TIAGEQY 70 I GE+Y Sbjct: 173 NKIVGEEY 180
>HTHFIS#FIS bacterial regulatory protein HTH signature. Length = 484 Score = 70.2 bits (172), Expect = 3e-15 Identities = 41/203 (20%), Positives = 83/203 (40%), Gaps = 10/203 (4%) Query: 29 SGLSVLLVDDQPFVGEVIRRALRSEHDIDLHVCTDAHRAMAVARDVKPTVILQDLVMPEI 88 +G ++L+ DD + V+ +AL D+ + ++A +++ D+VMP+ Sbjct: 2 TGATILVADDDAAIRTVLNQALSRA-GYDVRITSNAATLWRWIAAGDGDLVVTDVVMPDE 60 Query: 89 DGLDLVRAWRADAGTARVPIIVLSAKEEPIVKREAFIAGANDYLVKLPDAMELTARIRYH 148 + DL+ + +P++V+SA+ + +A GA DYL K D EL I Sbjct: 61 NAFDLLPRIKKAR--PDLPVLVMSAQNTFMTAIKASEKGAYDYLPKPFDLTELIGIIGRA 118 Query: 149 SNSYLMSRQRDEALDFLSHDMRSPQTSILALLD-VYRTEHGDMPAIMERIAGHARRALAL 207 + E + ++ + + R D+ ++ +G + +A Sbjct: 119 LAEPKRRPSKLEDDSQDGMPLVGRSAAMQEIYRVLARLMQTDLTLMITGESGTGKELVAR 178 Query: 208 ADGFIHLTRAQSERRAHEVVSLN 230 A +H +RR V++N Sbjct: 179 A---LH---DYGKRRNGPFVAIN 195
>HTHFIS#FIS bacterial regulatory protein HTH signature. Length = 484 Score = 74.9 bits (184), Expect = 3e-16 Identities = 33/119 (27%), Positives = 54/119 (45%), Gaps = 2/119 (1%) Query: 645 RRRVLVVDDSLTVRELERKLLEKRGYDVTVAVDGMEGWNAVRSDAFDLVVTDVDMPRMDG 704 +LV DD +R + + L + GYDV + + W + + DLVVTDV MP + Sbjct: 3 GATILVADDDAAIRTVLNQALSRAGYDVRITSNAATLWRWIAAGDGDLVVTDVVMPDENA 62 Query: 705 IELVTLIKGDPMLKRVPVMIVSYKDRDEDRRRGLDAGADYYLAKSSFHDEALLDAVHDL 763 +L+ IK +PV+++S ++ + + GA YL K E + L Sbjct: 63 FDLLPRIKK--ARPDLPVLVMSAQNTFMTAIKASEKGAYDYLPKPFDLTELIGIIGRAL 119
>PF07299#Fibronectin-binding protein (FBP) Length = 219 Score = 31.8 bits (72), Expect = 0.004 Identities = 13/59 (22%), Positives = 27/59 (45%), Gaps = 3/59 (5%) Query: 262 PLFEDASREQVSGLIHLKDLLLARHAGAALEDLSDYVRPVQYVKPDTPALE-LFRRFRK 319 +FE+ + EQ + + + A + L ++ YV P + + L+ LF + +K Sbjct: 52 HVFENLTDEQKELIDTVLTVQNREDAESFLLKINPYVIP--FQEVTAQTLKKLFPKAKK 108
>TCRTETB#Tetracycline resistance protein TetB signature. Length = 458 Score = 114 bits (286), Expect = 1e-29 Identities = 81/398 (20%), Positives = 155/398 (38%), Gaps = 12/398 (3%) Query: 8 VALATLDTAIANTALPAIAADLHASPAASVWIINAYQLAMVATLLPFASLGDIVGHKRVY 67 + L+ + N +LP IA D + PA++ W+ A+ L + L D +G KR+ Sbjct: 23 SFFSVLNEMVLNVSLPDIANDFNKPPASTNWVNTAFMLTFSIGTAVYGKLSDQLGIKRLL 82 Query: 68 VAGLAVFTLASL-GCSLASTLPMLTAARIVQGFGASAIMSVNVALIRGLFPAHRLGRGVG 126 + G+ + S+ G S +L AR +QG GA+A ++ + ++ P G+ G Sbjct: 83 LFGIIINCFGSVIGFVGHSFFSLLIMARFIQGAGAAAFPALVMVVVARYIPKENRGKAFG 142 Query: 127 FNALVVGVSFAVGPTIASLILSVAAWPWLFAVNVPLGVFALAVAIPSLPQTARGKHAFDP 186 +V + VGP I +I W +L + + + + + + L + R K FD Sbjct: 143 LIGSIVAMGEGVGPAIGGMIAHYIHWSYLLLIPM-ITIITVPFLMKLLKKEVRIKGHFDI 201 Query: 187 VAALFNVITFASLIFALGEFAQRGPLSVVFAAAAVAFSFGWLLIRRQAGHPAPMLPVDLF 246 + + + + S+ F +V + ++ P + L Sbjct: 202 KGIILMSVGIVFFMLFTTSY------SISFLIVSVLSFL--IFVKHIRKVTDPFVDPGLG 253 Query: 247 RRPVFTLSALTAVCAFAAQGLAFVSLPFYFETVLHRSAVETGF-LMTPWSAIVALAAPIA 305 + F + L F +P+ + V S E G ++ P + V + I Sbjct: 254 KNIPFMIGVLCGGIIFGTVAGFVSMVPYMMKDVHQLSTAEIGSVIIFPGTMSVIIFGYIG 313 Query: 306 GRLSDRYPPGLLGAIGLALLSAGMVSLAALPVSPGVVDIGWRMMLCGAGFGFFQSPNLKA 365 G L DR P + IG+ LS ++ + L + + ++ G F ++ Sbjct: 314 GILVDRRGPLYVLNIGVTFLSVSFLTASFLLETTSWF-MTIIIVFVLGGLSFTKTVISTI 372 Query: 366 LMSSAPPERSGGASGIIATARLIGQATGAALVALSFGI 403 + SS + +G ++ + + TG A+V I Sbjct: 373 VSSSLKQQEAGAGMSLLNFTSFLSEGTGIAIVGGLLSI 410
>SUBTILISIN#Subtilisin serine protease family (S8) signature. Length = 326 Score = 43.7 bits (103), Expect = 1e-06 Identities = 51/344 (14%), Positives = 97/344 (28%), Gaps = 75/344 (21%) Query: 235 TAAGVTVGIITIGGVSQTLQDLKQFTSSNGYGTVSTQTVKTNGTGGSYTDDQDGQGEWDL 294 GV V ++ G DLK + T+ G +D G Sbjct: 39 RGRGVKVAVLD-TGCDADHPDLK--------ARIIGGRNFTDDDEGDPEIFKDYNGHGTH 89 Query: 295 DSQSIVGSAGGQVGKLVFYMADLNA---------AGNTGLTQAFNRAVSDNTAKVINVSL 345 + +I + V ADL + Q A+ +I++SL Sbjct: 90 VAGTIAATENENGVVGVAPEADLLIIKVLNKQGSGQYDWIIQGIYYAIEQK-VDIISMSL 148 Query: 346 GWCETDANADGTLDAEEQIFTTAAAQGQTFSVSSGDEGVYECNNRGYPDGSNYTVSWPAS 405 G + + A A ++G+EG + + +P Sbjct: 149 G-------GPEDVPELHEAVKKAVASQILVMCAAGNEGDGDDRTD--------ELGYPGC 193 Query: 406 SPHVLAIGGTTLYTTSAGAFSNETVWNEGLDSNGKLWATGGGVSTILPAPSWQSGSNRQL 465 V+++G ++ FSN + L A G + + +P Sbjct: 194 YNEVISVGAINFDRHAS-EFSNSN-------NEVDLVAPGEDILSTVP------------ 233 Query: 466 PDVAFDAAQSTGAYIYNYGQLQQIGGTSLAAPIFTGFWARLLAANGTGLGFPASNFYADI 525 G+ GTS+A P G A + + ++ Sbjct: 234 -----------------GGKYATFSGTSMATPHVAGALALIKQLANASFERDLTE--PEL 274 Query: 526 PSHPSLVRYDVVSGNNGYQGYGY-KAGTGWDLTTGFGSLNIANL 568 + + R + + +G G +L+ F + +A + Sbjct: 275 YAQ-LIKRTIPLGNSPKMEGNGLLYLTAVEELSRIFDTQRVAGI 317
>PHPHTRNFRASE#Phosphoenolpyruvate-protein phosphotransferase signature. Length = 572 Score = 40.2 bits (94), Expect = 1e-05 Identities = 30/143 (20%), Positives = 53/143 (37%), Gaps = 13/143 (9%) Query: 127 GVRIHDFSHPH-WRDDVRIVLRASR-APAYITLPKIANAADAAEMTAFIEGTRREL---- 180 +R+ +R +R +LRAS + P IA + + A ++ + +L Sbjct: 360 AIRL-CLEKQDIFRTQLRALLRASTYGNLKVMFPMIATLEELRQAKAIMQEEKDKLLSEG 418 Query: 181 -GIAQPIPVDVLIETHGALAQAAALAALPTVGTLSFGLMDFVSAHHGAIPDSAMRSPGQF 239 ++ I V +++E A A V S G D + A + S + Sbjct: 419 VDVSDSIEVGIMVEIPSTAVAANLFA--KEVDFFSIGTNDLIQYTMAADRMNERVSY-LY 475 Query: 240 D--HPLVRRAKLEIAAACHAHGK 260 HP + R + A H+ GK Sbjct: 476 QPYHPAILRLVDMVIKAAHSEGK 498
>BCTERIALGSPD#Bacterial general secretion pathway protein D signature. Length = 660 Score = 30.7 bits (69), Expect = 0.008 Identities = 9/33 (27%), Positives = 17/33 (51%) Query: 9 SLVDGDVAHNTRKVIDTIERVDVAGGTKLIVFP 41 L+ A ++++ +ERVD AG ++ P Sbjct: 166 VLLMTGRAAVIKRLLTIVERVDNAGDRSVVTVP 198
>DHBDHDRGNASE#2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase signature. Length = 261 Score = 92.8 bits (230), Expect = 1e-24 Identities = 68/263 (25%), Positives = 116/263 (44%), Gaps = 25/263 (9%) Query: 7 LQGKRVLVTGGTMGVGKAVVGLFRELGAKVLTTARTPPADTPADIFVAA----------D 56 ++GK +TG G+G+AV GA + P + A D Sbjct: 6 IEGKIAFITGAAQGIGEAVARTLASQGAHIAAVDYNPEKLEKVVSSLKAEARHAEAFPAD 65 Query: 57 LATLEGCEAVAEAVMANFGGVDVIVHVVGGSRSPAGGFAALSEDAWQDELNLNLLPAVRL 116 + + + + G +D++V+V G R G +LS++ W+ ++N Sbjct: 66 VRDSAAIDEITARIEREMGPIDILVNVAGVLR--PGLIHSLSDEEWEATFSVNSTGVFNA 123 Query: 117 DRALLPGMLAQRAGVVIHVTSIQRALPLPESTTAYAAAKAGLSTYSKSLSKEVSPKGIRV 176 R++ M+ +R+G ++ V S +P S AYA++KA ++K L E++ IR Sbjct: 124 SRSVSKYMMDRRSGSIVTVGSNPAGVP-RTSMAAYASSKAAAVMFTKCLGLELAEYNIRC 182 Query: 177 IRVAPGWIETEAAVAFAERLAEQAGTDYEGGKQIIMDSLG----GIPLGRPSTPGEVANL 232 V+PG ET+ + D G +Q+I SL GIPL + + P ++A+ Sbjct: 183 NIVSPGSTETD--------MQWSLWADENGAEQVIKGSLETFKTGIPLKKLAKPSDIADA 234 Query: 233 IAFLASPRAASITGAEYVIDGGT 255 + FL S +A IT +DGG Sbjct: 235 VLFLVSGQAGHITMHNLCVDGGA 257
>DHBDHDRGNASE#2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase signature. Length = 261 Score = 39.6 bits (92), Expect = 4e-06 Identities = 33/187 (17%), Positives = 67/187 (35%), Gaps = 5/187 (2%) Query: 14 ILLVAASRGLGLAMAEAFLNKGWHVTGTVREGSGRTKLHDLADRFDGRLEIGTLDICEPA 73 + A++G+G A+A ++G H+ K+ E D+ + A Sbjct: 11 AFITGAAQGIGEAVARTLASQGAHIAAVDYNPEKLEKVVSSLKAEARHAEAFPADVRDSA 70 Query: 74 QLAALRERLSGR--RFDMLFVNAGTTNDPNETIGEVTTDEFVRVMITNALAPMRAIETLQ 131 + + R+ D+L AG I ++ +E+ N+ A ++ Sbjct: 71 AIDEITARIEREMGPIDILVNVAGVLR--PGLIHSLSDEEWEATFSVNSTGVFNASRSVS 128 Query: 132 DLVPDDGLIGAMSSGQGSVANNVTGMREVYRGSKAALNQFMRSFAARQADTRRALALMAP 191 + D G++ + + A Y SKAA F + A+ +++P Sbjct: 129 KYMMDRRS-GSIVTVGSNPAGVPRTSMAAYASSKAAAVMFTKCLGLELAEYNIRCNIVSP 187 Query: 192 GWVRTEL 198 G T++ Sbjct: 188 GSTETDM 194
>TCRTETB#Tetracycline resistance protein TetB signature. Length = 458 Score = 39.9 bits (93), Expect = 1e-05 Identities = 31/154 (20%), Positives = 59/154 (38%), Gaps = 3/154 (1%) Query: 26 LPAISAGLHVSIAAAGQLTTIFSAVFALAALVAASFVARVERRTALLAALGAFAAANLCA 85 LP I+ + A+ + T F F++ V ++ + LL + ++ Sbjct: 37 LPDIANDFNKPPASTNWVNTAFMLTFSIGTAVYGKLSDQLGIKRLLLFGIIINCFGSVIG 96 Query: 86 AASPGYAS-LFAARVLMAASCATLILVATRFAAELAPVSQRGRAIGIVFMGISASLVLGV 144 + S L AR + A A + A P RG+A G++ ++ +G Sbjct: 97 FVGHSFFSLLIMARFIQGAGAAAFPALVMVVVARYIPKENRGKAFGLIGSIVAMGEGVGP 156 Query: 145 PIGMRIAEWAGWRAVFV--SIAVAALPLGIWLAR 176 IG IA + W + + I + +P + L + Sbjct: 157 AIGGMIAHYIHWSYLLLIPMITIITVPFLMKLLK 190
>ISCHRISMTASE#Isochorismatase signature. Length = 312 Score = 52.7 bits (126), Expect = 2e-10 Identities = 39/186 (20%), Positives = 66/186 (35%), Gaps = 4/186 (2%) Query: 30 LLIVDFVVGFADPATFGGGNIAPAIARTTKALALARERGWPVAHSRIVYADDGSDDNVFS 89 LLI D F D T G + A K + G PV ++ + + D + + Sbjct: 33 LLIHDMQNYFVDAFTAGASPVTELSANIRKLKNQCVQLGIPVVYTAQPGSQNPDDRALLT 92 Query: 90 -LKVPGMATLTEHHPNSAIVPELTPAPGELVVRKTVPSAFFGTQLAPWLAQRAVQTLLVA 148 PG+ + I+ EL P +LV+ K SAF T L + + L++ Sbjct: 93 DFWGPGLNSGPYEEK---IITELAPEDDDLVLTKWRYSAFKRTNLLEMMRKEGRDQLIIT 149 Query: 149 GAVTSGCVRASVVDAMSHGFRPLVLADCVGDRAIAPHDANLFDMQQKYAAVMPLDDAIAA 208 G + +A + + D V D ++ H L + A + D + Sbjct: 150 GIYAHIGCLVTACEAFMEDIKAFFVGDAVADFSLEKHQMALEYAAGRCAFTVMTDSLLDQ 209 Query: 209 IDAVQA 214 + A Sbjct: 210 LQNAPA 215
>HTHFIS#FIS bacterial regulatory protein HTH signature. Length = 484 Score = 60.2 bits (146), Expect = 4e-12 Identities = 28/114 (24%), Positives = 47/114 (41%), Gaps = 3/114 (2%) Query: 23 VLLVDDQTIVAEAVRRALVDEEGIDFHYCPRSDDAMATAVETRPTVILQDLVMPGTDGLS 82 +L+ DD + + +AL G D + +++ D+VMP + Sbjct: 6 ILVADDDAAIRTVLNQALSRA-GYDVRITSNAATLWRWIAAGDGDLVVTDVVMPDENAFD 64 Query: 83 LVKAYRANPATRDVPIIVLSTQEEPVIKSATFASGANDYLVKLPDRIELVARIR 136 L+ + A D+P++V+S Q + GA DYL K D EL+ I Sbjct: 65 LLPRIKK--ARPDLPVLVMSAQNTFMTAIKASEKGAYDYLPKPFDLTELIGIIG 116
>HTHFIS#FIS bacterial regulatory protein HTH signature. Length = 484 Score = 44.8 bits (106), Expect = 3e-07 Identities = 26/134 (19%), Positives = 51/134 (38%), Gaps = 4/134 (2%) Query: 5 IVNDLPLAVEAMRRAIARRPEHRVLWVATDGPQAVELCAAQPPDIVLMDLIMPKFDGIEA 64 + +D + +A++R + V + ++ AA D+V+ D++MP + + Sbjct: 8 VADDDAAIRTVLNQALSRAG-YDVR-ITSNAATLWRWIAAGDGDLVVTDVVMPDENAFDL 65 Query: 65 TRRIMRSERPCAILIVTSCIGANAWRVFEAMGAGALDAVDTPRLGDGAAGDTTKLLLAKI 124 RI + RP ++V S + +A GA D + P G + L Sbjct: 66 LPRI-KKARPDLPVLVMSAQNTFMTAI-KASEKGAYDYLPKPFDLTELIGIIGRALAEPK 123 Query: 125 DQIGRLLDAPGSSR 138 + +L D Sbjct: 124 RRPSKLEDDSQDGM 137
>HTHFIS#FIS bacterial regulatory protein HTH signature. Length = 484 Score = 67.2 bits (164), Expect = 2e-16 Identities = 25/117 (21%), Positives = 52/117 (44%), Gaps = 3/117 (2%) Query: 2 AKILVVDDSGTVRDEVAGFLRNHGLDVATAVDGKDGLAKLKATPGVRLVISDVNMPNMDG 61 A ILV DD +R + L G DV + + A G LV++DV MP+ + Sbjct: 4 ATILVADDDAAIRTVLNQALSRAGYDVRITSNAATLWRWIAAGDG-DLVVTDVVMPDENA 62 Query: 62 LTMVEKIRGELANTAVNVVMLTTESSPAMKERGKAAGVKGWIVKPFKGDAVLDALKK 118 ++ +I+ + V++++ +++ + G ++ KPF ++ + + Sbjct: 63 FDLLPRIKKARPDLP--VLVMSAQNTFMTAIKASEKGAYDYLPKPFDLTELIGIIGR 117
>TCRTETB#Tetracycline resistance protein TetB signature. Length = 458 Score = 145 bits (368), Expect = 8e-41 Identities = 90/397 (22%), Positives = 164/397 (41%), Gaps = 18/397 (4%) Query: 39 FMAVLDSTIVNVALPAMRTSLGATVAELAWIVDAYTLSFAALILAGGALSDRFGAKRVYL 98 F +VL+ ++NV+LP + A W+ A+ L+F+ G LSD+ G KR+ L Sbjct: 24 FFSVLNEMVLNVSLPDIANDFNKPPASTNWVNTAFMLTFSIGTAVYGKLSDQLGIKRLLL 83 Query: 99 AGLALFVGASAACGVA-SSVALLVAARFAQGMGAALFLPASLAIVRSTFDVPAERARAIA 157 G+ + S V S +LL+ ARF QG GAA F PA + +V + + R +A Sbjct: 84 FGIIINCFGSVIGFVGHSFFSLLIMARFIQGAGAAAF-PALVMVVVARYIPKENRGKAFG 142 Query: 158 VWAGIASVAVAVGPVLGGLLVDDFGWRSAFLINVPTGAVAFAGAAALVRAAAAREVRQFD 217 + I ++ VGP +GG++ W ++L+ +P + + R FD Sbjct: 143 LIGSIVAMGEGVGPAIGGMIAHYIHW--SYLLLIPMITIITVPFLMKLLKKEVRIKGHFD 200 Query: 218 WVGQCVGAAALGALCFAVIELPTRGAGATEVRCALLIAVLAAAVLVAVERRARHPMVPLA 277 G L I + L+++VL+ + V R+ P V Sbjct: 201 IKG--------IILMSVGIVFFMLFT-TSYSISFLIVSVLSFLIFVKHIRKVTDPFVDPG 251 Query: 278 WFRNRVFVAMNLMGSLVYVGYFGLLFVLSLYLHGRFGMSARQIG-LTLLPFALSLSLGNL 336 +N F+ L G +++ G + ++ + +S +IG + + P +S+ + Sbjct: 252 LGKNIPFMIGVLCGGIIFGTVAGFVSMVPYMMKDVHQLSTAEIGSVIIFPGTMSVIIFGY 311 Query: 337 LSGKLHGRVRPVTLMANGLAMAALAVPAIALALALRAPWLVVWMAMAAFGTGTALSVAPM 396 + G L R P+ ++ G+ +++ + L W + + + G + + Sbjct: 312 IGGILVDRRGPLYVLNIGVTFLSVSFLTASF-LLETTSWFMTIIIVFVLGGLSFTKT--V 368 Query: 397 IATVLEQVPADA-AGVASGFLNAARQAGSLLGVAIAG 432 I+T++ AG LN G+AI G Sbjct: 369 ISTIVSSSLKQQEAGAGMSLLNFTSFLSEGTGIAIVG 405
>TCRTETB#Tetracycline resistance protein TetB signature. Length = 458 Score = 44.1 bits (104), Expect = 9e-07 Identities = 35/159 (22%), Positives = 61/159 (38%), Gaps = 2/159 (1%) Query: 47 APVIRSEWGLSPAQLAPVFGAGLAGLMAGALVFGPFGDRFGRKRLLLACVACFGIAS-AA 105 P I +++ PA V A + G V+G D+ G KRLLL + S Sbjct: 37 LPDIANDFNKPPASTNWVNTAFMLTFSIGTAVYGKLSDQLGIKRLLLFGIIINCFGSVIG 96 Query: 106 SGSAGGLTELIVWRFVTGLGLGGAMPNAITLTSEYCPARRRSLLVTTMFCGFTIGSALGG 165 + LI+ RF+ G G + + + Y P R + +G +G Sbjct: 97 FVGHSFFSLLIMARFIQGAGAAAFPALVMVVVARYIPKENRGKAFGLIGSIVAMGEGVGP 156 Query: 166 LAAASLIEHHGWRAVLVVGGVAPLLLLPLLAWRLPESVR 204 + + W +L++ + ++ +P L L + VR Sbjct: 157 AIGGMIAHYIHWSYLLLI-PMITIITVPFLMKLLKKEVR 194
>PF07520#Virulence protein SrfB Length = 1041 Score = 31.1 bits (70), Expect = 0.009 Identities = 17/77 (22%), Positives = 23/77 (29%), Gaps = 6/77 (7%) Query: 167 DPLGLFDEILCPSPFMRDLIARFGRTPATLLPNPID----TTLVPRTPKPARRG--RLDL 220 L F E P P +R R P P T+ P P R+ + Sbjct: 91 AALEPFLEKWVPIPVLRLKNQRGAGGEELYDPGPSSWARLRTVELPQPDPETGHTHRVQI 150 Query: 221 AFVGRLEADKGLAQFLA 237 A L A ++A Sbjct: 151 ALDTALSDQDQSAHYVA 167
>HTHFIS#FIS bacterial regulatory protein HTH signature. Length = 484 Score = 392 bits (1008), Expect = e-135 Identities = 148/469 (31%), Positives = 223/469 (47%), Gaps = 42/469 (8%) Query: 33 LRKELSRRDWKVSVVAHANELRD--TSGEITCGILDLSGGHADAIGSIASTCASMRDVVW 90 L + LSR + V + ++A L +G+ + D+ +A + Sbjct: 19 LNQALSRAGYDVRITSNAATLWRWIAAGDGDLVVTDVVMPDENAFDLLPR--IKKARPDL 76 Query: 91 VALVDVGQTASPNVRALLRDYCFDYVTLPASHQRIADTVGHAYGMECLFARDREQLESEE 150 LV Q +DY+ P + +G A E + Sbjct: 77 PVLVMSAQNTFMTAIKASEKGAYDYLPKPFDLTELIGIIGRALAEPKRRPSKLEDDSQDG 136 Query: 151 KGIVGTCSAMLRLFDTVRRFARTDAPVFVFGETGTGKELTAVAIHRHSERRNGPFVAVNC 210 +VG +AM ++ + R +TD + + GE+GTGKEL A A+H + +RRNGPFVA+N Sbjct: 137 MPLVGRSAAMQEIYRVLARLMQTDLTLMITGESGTGKELVARALHDYGKRRNGPFVAINM 196 Query: 211 GAIPPHLLQSELFGYERGAFTGANARKIGYVEAANGGTLLLDEIGDLPHESQASLLRFLQ 270 AIP L++SELFG+E+GAFTGA R G E A GGTL LDEIGD+P ++Q LLR LQ Sbjct: 197 AAIPRDLIESELFGHEKGAFTGAQTRSTGRFEQAEGGTLFLDEIGDMPMDAQTRLLRVLQ 256 Query: 271 ERSIHRLGGSDPVPVDVRIVSATHVDLREAMEEGRFRADLFHRLCVMRIDQPPLRARGKD 330 + +GG P+ DVRIV+AT+ DL++++ +G FR DL++RL V+ + PPLR R +D Sbjct: 257 QGEYTTVGGRTPIRSDVRIVAATNKDLKQSINQGLFREDLYYRLNVVPLRLPPLRDRAED 316 Query: 331 IELLAHHMLERFRGDARHRVRGFSTDAITALYKHDWPGNVRELINRVRRAVVMTEGRLIT 390 I L H +++ + V+ F +A+ + H WPGNVREL N VRR + +IT Sbjct: 317 IPDLVRHFVQQAEKEGL-DVKRFDQEALELMKAHPWPGNVRELENLVRRLTALYPQDVIT 375 Query: 391 AQDLELEYCLDAASPSVA-------------------------------------DIRKS 413 + +E E + + + Sbjct: 376 REIIENELRSEIPDSPIEKAAARSGSLSISQAVEENMRQYFASFGDALPPSGLYDRVLAE 435 Query: 414 IEREAIEIALLRTRGRVAASARELGVSRATLYRWMEAYGIERPRGTGSS 462 +E I AL TRG +A LG++R TL + + G+ R + S+ Sbjct: 436 MEYPLILAALTATRGNQIKAADLLGLNRNTLRKKIRELGVSVYRSSRSA 484
>TCRTETB#Tetracycline resistance protein TetB signature. Length = 458 Score = 64.5 bits (157), Expect = 2e-13 Identities = 44/182 (24%), Positives = 72/182 (39%), Gaps = 6/182 (3%) Query: 11 WLFLLMLVVCLPRVTIDAYLPSLPAMADALHGTDAQLQLTLTLYMVGYALSMLVSGPLSD 70 WL +L L + ++ SLP +A+ + A T +M+ +++ V G LSD Sbjct: 18 WLCILSFFSVLNEMVLNV---SLPDIANDFNKPPASTNWVNTAFMLTFSIGTAVYGKLSD 74 Query: 71 RYRRRPVLLGGLCVYVVASVACAWSTS-IPALIAARVFQALGGCCGTVIGRVIVRERFPA 129 + + +LL G+ + SV S LI AR Q G + V+V P Sbjct: 75 QLGIKRLLLFGIIINCFGSVIGFVGHSFFSLLIMARFIQGAGAAAFPALVMVVVARYIPK 134 Query: 130 ATQATMLGHISASMALSPVVAPLAGSAIAEWLGWRGVFGWLAAGGLVATAMVLRYLPETR 189 + G I + +A+ V P G IA ++ W + + T L L + Sbjct: 135 ENRGKAFGLIGSIVAMGEGVGPAIGGMIAHYIHWSYLLLIPMI--TIITVPFLMKLLKKE 192 Query: 190 ER 191 R Sbjct: 193 VR 194
>HTHFIS#FIS bacterial regulatory protein HTH signature. Length = 484 Score = 97.2 bits (242), Expect = 1e-25 Identities = 36/128 (28%), Positives = 63/128 (49%), Gaps = 1/128 (0%) Query: 2 RVLLVEDNPNLAQSLNDALSAARFAVDHMADGEAADHVLRTQDYALVILDLGLPKLDGLE 61 +L+ +D+ + LN ALS A + V ++ + D LV+ D+ +P + + Sbjct: 5 TILVADDDAAIRTVLNQALSRAGYDVRITSNAATLWRWIAAGDGDLVVTDVVMPDENAFD 64 Query: 62 VLRRLRARRNPVPVLILTAHGSVEDRVKGLDLGADDYLAKPFELTE-LEARARALIRRSL 120 +L R++ R +PVL+++A + +K + GA DYL KPF+LTE + RAL Sbjct: 65 LLPRIKKARPDLPVLVMSAQNTFMTAIKASEKGAYDYLPKPFDLTELIGIIGRALAEPKR 124 Query: 121 GHEHSRVE 128 + Sbjct: 125 RPSKLEDD 132
>PF06580#Sensor histidine kinase Length = 349 Score = 45.2 bits (107), Expect = 3e-07 Identities = 19/104 (18%), Positives = 40/104 (38%), Gaps = 24/104 (23%) Query: 367 LIDNAIRYA----GDHAVITVRISRDGEQARLDVIDNGPGIPADERDAVFERFHRGSKTQ 422 L++N I++ I ++ ++D L+V + G + + Sbjct: 263 LVENGIKHGIAQLPQGGKILLKGTKDNGTVTLEVENTGSLALKNTK-------------- 308 Query: 423 TVEGTGLGLSIVRE-IARVH--QGSVTLADAAGGGLVVTIRLPA 463 E TG GL VRE + ++ + + L++ G + +P Sbjct: 309 --ESTGTGLQNVRERLQMLYGTEAQIKLSEKQGKV-NAMVLIPG 349
>DHBDHDRGNASE#2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase signature. Length = 261 Score = 91.3 bits (226), Expect = 5e-24 Identities = 68/258 (26%), Positives = 110/258 (42%), Gaps = 11/258 (4%) Query: 5 LKGKTAVVTASTAGIGLAIAEGLARAGAHVVVNGRSDPSVQSALEKLRDTVPGASFDGVA 64 ++GK A +T + GIG A+A LA GAH+ +P + + Sbjct: 6 IEGKIAFITGAAQGIGEAVARTLASQGAHIAA-VDYNPEKLEKVVS-SLKAEARHAEAFP 63 Query: 65 ADLSDAAGVARVTQ----HTPNADILVNNAGIYGLKAFFDIDDAEWEHYFQINVMSGVRL 120 AD+ D+A + +T DILVN AG+ + D EWE F +N Sbjct: 64 ADVRDSAAIDEITARIEREMGPIDILVNVAGVLRPGLIHSLSDEEWEATFSVNSTGVFNA 123 Query: 121 ARHYLKGMIERNAGRIVFISSESGLNIPVDMIHYGFTKTAQLSIARGLAKLAAGTHVTVN 180 +R K M++R +G IV + S M Y +K A + + L A ++ N Sbjct: 124 SRSVSKYMMDRRSGSIVTVGSNPAGVPRTSMAAYASSKAAAVMFTKCLGLELAEYNIRCN 183 Query: 181 SVLPGPTMSEGVREMLKAQADETGRSIDDIAVEFVRSERASSIIQRPATTEEVANLVVYV 240 V PG T ++ ++ L A + + I F + +++ A ++A+ V+++ Sbjct: 184 IVSPGSTETD-MQWSLWADENGAEQVIKGSLETF----KTGIPLKKLAKPSDIADAVLFL 238 Query: 241 CSPQASATTGAALRVDGG 258 S QA T L VDGG Sbjct: 239 VSGQAGHITMHNLCVDGG 256
>PF06580#Sensor histidine kinase Length = 349 Score = 36.8 bits (85), Expect = 2e-04 Identities = 29/133 (21%), Positives = 54/133 (40%), Gaps = 31/133 (23%) Query: 303 RASDLKDVSLADEVRRMLDFLEIPLDEAQLRAELHGDARAAVDPSLFRRAMTNLLI---- 358 R S+ + VSLADE+ + +L++ A ++ E ++P++ + +L+ Sbjct: 209 RYSNARQVSLADELTVVDSYLQL----ASIQFEDRLQFENQINPAIMDVQVPPMLVQTLV 264 Query: 359 -NAIQH----SAPGATLNVTITRRDTLVEMAVSNPGEPIDPVQRSHVFERFYRLEEARAN 413 N I+H G + + T+ + V + V N G N Sbjct: 265 ENGIKHGIAQLPQGGKILLKGTKDNGTVTLEVENTGSLALK------------------N 306 Query: 414 SKENHGLGLSIVK 426 +KE+ G GL V+ Sbjct: 307 TKESTGTGLQNVR 319
>HTHFIS#FIS bacterial regulatory protein HTH signature. Length = 484 Score = 84.9 bits (210), Expect = 4e-21 Identities = 35/139 (25%), Positives = 66/139 (47%), Gaps = 3/139 (2%) Query: 2 KVLIVEDEPKVVEYLKSGLTEEGWVVDTALDGEDGAWKAVE-FDYDVVVLDVMLPKLDGF 60 +L+ +D+ + L L+ G+ V + W+ + D D+VV DV++P + F Sbjct: 5 TILVADDDAAIRTVLNQALSRAGYDVRITSNAAT-LWRWIAAGDGDLVVTDVVMPDENAF 63 Query: 61 GVLRALRA-QKQTPVIMLTARDRVDDRVRGLRGGADDYLTKPFSFLELIERLRALTRRAR 119 +L ++ + PV++++A++ ++ GA DYL KPF ELI + + Sbjct: 64 DLLPRIKKARPDLPVLVMSAQNTFMTAIKASEKGAYDYLPKPFDLTELIGIIGRALAEPK 123 Query: 120 VQESTLISIGDLRVDLIGR 138 + S L + L+GR Sbjct: 124 RRPSKLEDDSQDGMPLVGR 142
>RTXTOXIND#Gram-negative bacterial RTX secretion protein D signature. Length = 478 Score = 30.2 bits (68), Expect = 0.020 Identities = 14/102 (13%), Positives = 37/102 (36%) Query: 162 RNVEAAQASTEQSRDDFANARLVLSADLASSYFTLRELDTEIDVVKRSIDLQQKALDYVS 221 V + ++ + N + +L + I+ + +++ LD S Sbjct: 182 EEVLRLTSLIKEQFSTWQNQKYQKELNLDKKRAERLTVLARINRYENLSRVEKSRLDDFS 241 Query: 222 ARHDLGAVSGLDLLQQRAQLDATRTQAQLLIQQRAQVETAIA 263 + A++ +L+Q + + ++ Q Q+E+ I Sbjct: 242 SLLHKQAIAKHAVLEQENKYVEAVNELRVYKSQLEQIESEIL 283
>RTXTOXIND#Gram-negative bacterial RTX secretion protein D signature. Length = 478 Score = 39.4 bits (92), Expect = 2e-05 Identities = 21/193 (10%), Positives = 53/193 (27%), Gaps = 22/193 (11%) Query: 86 ASGYVLRWQADIGAHVKQGQTLAELDTPELNQELAQATAQRQQAQAALALAKTS------ 139 + V G V++G L +L + + + QA+ + Sbjct: 103 ENSIVKEIIVKEGESVRKGDVLLKLTALGAEADTLKTQSSLLQARLEQTRYQILSRSIEL 162 Query: 140 ----------FDRAQQLRQRDAVSQQELDDRQGAFSQGSANLAAADANMRRLT-ELKGFQ 188 Q + + + + L + FS + N+ + E Sbjct: 163 NKLPELKLPDEPYFQNVSEEEVLRLTSL--IKEQFSTWQNQKYQKELNLDKKRAERLTVL 220 Query: 189 RIVAPID---GIVTQRNVDVGDLVNSGNAGRSLFTVVQADRLRLYVQVPQAYAQQVKVGQ 245 + + + R D L++ + + + ++ +Q ++ Sbjct: 221 ARINRYENLSRVEKSRLDDFSSLLHKQAIAKHAVLEQENKYVEAVNELRVYKSQLEQIES 280 Query: 246 HVSVAQAELPGRT 258 + A+ E T Sbjct: 281 EILSAKEEYQLVT 293
>ACRIFLAVINRP#Acriflavin resistance protein family signature. Length = 1034 Score = 636 bits (1641), Expect = 0.0 Identities = 247/1056 (23%), Positives = 442/1056 (41%), Gaps = 51/1056 (4%) Query: 3 IVNLALRRPYTFIVMAIMIVLATPLALMRTPVDVLPAINIPVISVIWNYSGFSATEMTNR 62 + N +RRP V+AI++++A LA+++ PV P I P +SV NY G A + + Sbjct: 1 MANFFIRRPIFAWVLAIILMMAGALAILQLPVAQYPTIAPPAVSVSANYPGADAQTVQDT 60 Query: 63 ITSVHERILTTTVNNIQHVESTSLP-GIAVVKVFLQPGANVQTAIAQTVSSAQAIVRQMP 121 +T V E+ + ++N+ ++ STS G + + Q G + A Q + Q +P Sbjct: 61 VTQVIEQNMNG-IDNLMYMSSTSDSAGSVTITLTFQSGTDPDIAQVQVQNKLQLATPLLP 119 Query: 122 QGATPPLVITYSASSIPVIQLGLSSQTLSEQ--SLADIALNFLRPQLITVPGVQIPFPYG 179 Q + +SS ++ G S ++D + ++ L + GV +G Sbjct: 120 QEVQQQGISVEKSSSSYLMVAGFVSDNPGTTQDDISDYVASNVKDTLSRLNGVGDVQLFG 179 Query: 180 GRTRVVAIDLDPQALQAKGLTPADIVNAVNAQNLVLPTGT-----AKMGQT-EYRIDTNA 233 + + I LD L LTP D++N + QN + G A GQ I Sbjct: 180 AQ-YAMRIWLDADLLNKYKLTPVDVINQLKVQNDQIAAGQLGGTPALPGQQLNASIIAQT 238 Query: 234 SADTVADISNLPVQT-INGATTYLREVAAVRDGFAPQTNVVRQNGQRGVLISILKSGDAS 292 + + ++ +G+ L++VA V G + R NG+ + I + A+ Sbjct: 239 RFKNPEEFGKVTLRVNSDGSVVRLKDVARVELGGENYNVIARINGKPAAGLGIKLATGAN 298 Query: 293 TLKVVSDLKALLPKVIPTLPEGLTITPLFDQSVFVNAAVQGVIHEALIAAVLTAMMILLF 352 L +KA L ++ P P+G+ + +D + FV ++ V+ A +L +++ LF Sbjct: 299 ALDTAKAIKAKLAELQPFFPQGMKVLYPYDTTPFVQLSIHEVVKTLFEAIMLVFLVMYLF 358 Query: 353 LGNWRSTLIIAISIPLSIFTSLIALSALGETINIMTLGGLALAVGILVDDATVTIENIER 412 L N R+TLI I++P+ + + L+A G +IN +T+ G+ LA+G+LVDDA V +EN+ER Sbjct: 359 LQNMRATLIPTIAVPVVLLGTFAILAAFGYSINTLTMFGMVLAIGLLVDDAIVVVENVER 418 Query: 413 HLH-LGTNLHDAILEGAGEIAVPALVSTLCICIVFVPMFFLTGVARFLFVPLAEAVVFAM 471 + +A + +I + + + VF+PM F G ++ + +V AM Sbjct: 419 VMMEDKLPPKEATEKSMSQIQGALVGIAMVLSAVFIPMAFFGGSTGAIYRQFSITIVSAM 478 Query: 472 LASYVLSRTLVPTLAMLLFRPQQANTGADHSTSRFARIHHAFNHAFERLRAWYIVLLTIL 531 S +++ L P L L +P A+H ++ FN F+ Y + + Sbjct: 479 ALSVLVALILTPALCATLLKPV----SAEHHENK-GGFFGWFNTTFDHSVNHYTNSVGKI 533 Query: 532 LVRRRFYALCFLGFCVLSTGLVFMLGRDFFPNADSGNLRLHVRAPTGYRIEETARLADQV 591 L Y L + L L F P D G ++ P G E T ++ DQV Sbjct: 534 LGSTGRYLLIYALIVAGMVVLFLRLPSSFLPEEDQGVFLTMIQLPAGATQERTQKVLDQV 593 Query: 592 ERVIRATVPPDELGAIVDNLGLPVSGINLSYSNAGTIGTLDGELLIALKPGHRATGH--- 648 L N+ + S+S G ++LKP G Sbjct: 594 TDYY--------LKNEKANVESVFTVNGFSFSGQAQN---AGMAFVSLKPWEERNGDENS 642 Query: 649 ---YVQTLRTLLPQRFPGVEFFFQPSDIITQILNFGQPAAIDVQVLGNDLASNMTIAS-S 704 + + L + G F I+ L ++ +T A Sbjct: 643 AEAVIHRAKMELGKIRDGFVIPFNMPAIVE--LGTATGFDFELIDQAGLGHDALTQARNQ 700 Query: 705 LMKKIRQIPGAV-DVHVLQRNDEPTLLADMDRTRMQQLNLSAQNVAQNMLISLSGSSQTT 763 L+ Q P ++ V D ++D+ + Q L +S ++ Q + +L G+ Sbjct: 701 LLGMAAQHPASLVSVRPNGLEDTAQFKLEVDQEKAQALGVSLSDINQTISTALGGTYVND 760 Query: 764 PSFWINPRTGVQYPLQIQTPQYNLSSVDDLLGTPISASGRTGTPLQLLGNLVQVRSTVNP 823 G L +Q +D+ + ++ P Sbjct: 761 -----FIDRGRVKKLYVQADAKFRMLPEDVDKLYVRSANGEMVP---FSAFTTSHWVYGS 812 Query: 824 AVITHYNIRPAIDVYVSVEGRDLGAVAGEIDRIVADARATLPRGTDLTMRGQIETMRTSY 883 + YN P++++ G +G+ ++ + + LP G G R S Sbjct: 813 PRLERYNGLPSMEIQGEAAP---GTSSGDAMALMENLASKLPAGIGYDWTGMSYQERLSG 869 Query: 884 IGLGAGVAMAIVLVYLLIVVNFQSWLDPLIIISAMPAALAGIAWMLFITGTHLSVPALTG 943 A VA++ V+V+L + ++SW P+ ++ +P + G+ + V + G Sbjct: 870 NQAPALVAISFVVVFLCLAALYESWSIPVSVMLVVPLGIVGVLLAATLFNQKNDVYFMVG 929 Query: 944 AIMTVGVATANSILVVSFARQRLAA-GAPPLTAALEAGATRIRPVLMTALAMIIGMVPMA 1002 + T+G++ N+IL+V FA+ + G + A L A R+RP+LMT+LA I+G++P+A Sbjct: 930 LLTTIGLSAKNAILIVEFAKDLMEKEGKGVVEATLMAVRMRLRPILMTSLAFILGVLPLA 989 Query: 1003 LGLGEGAEQNAPLGRAVIGGLLFATVSTLLFVPLVF 1038 + G G+ +G V+GG++ AT+ + FVP+ F Sbjct: 990 ISNGAGSGAQNAVGIGVMGGMVSATLLAIFFVPVFF 1025 Score = 126 bits (319), Expect = 1e-31 Identities = 82/517 (15%), Positives = 179/517 (34%), Gaps = 43/517 (8%) Query: 3 IVNLALRRPYTFIVMAIMIVLATPLALMRTPVDVLPAINIPVISVIWNY-SGFSATEMTN 61 V L ++++ +IV + +R P LP + V + +G + Sbjct: 529 SVGKILGSTGRYLLIYALIVAGMVVLFLRLPSSFLPEEDQGVFLTMIQLPAGATQERTQK 588 Query: 62 RITSVHERILTTTVNNIQHVESTSLPGIAVVKVFLQPGANVQTAIAQTV----------- 110 + V + L N++ V V F G +A Sbjct: 589 VLDQVTDYYLKNEKANVESV--------FTVNGFSFSGQAQNAGMAFVSLKPWEERNGDE 640 Query: 111 SSAQAIV-RQMPQGATPPLVITYSASSIPVIQLGLSS----QTLSEQSLADIALNFLRPQ 165 +SA+A++ R + + +++LG ++ + + + L AL R Q Sbjct: 641 NSAEAVIHRAKMELGKIRDGFVIPFNMPAIVELGTATGFDFELIDQAGLGHDALTQARNQ 700 Query: 166 LITVPGVQIPFPYGGRTRVVA------IDLDPQALQAKGLTPADIVNAVNAQNLVLPTGT 219 L+ + R + +++D + QA G++ +DI ++ Sbjct: 701 LLGMAAQHPASLVSVRPNGLEDTAQFKLEVDQEKAQALGVSLSDINQTISTALGGTYVND 760 Query: 220 AKMGQTEYRIDTNASAD---TVADISNLPVQTINGATTYLREVAAVRDGFAPQTNVVRQN 276 ++ A A D+ L V++ NG + + R N Sbjct: 761 FIDRGRVKKLYVQADAKFRMLPEDVDKLYVRSANGEMVPFSAFTTSHWVYGS-PRLERYN 819 Query: 277 GQRGVLISILKSGDASTLKVVSDLKALLPKVIPTLPEGLTITPLFDQSVFVNAAVQGVIH 336 G + I + S+ ++ ++ L K LP G+ + Q Sbjct: 820 GLPSMEIQGEAAPGTSSGDAMALMENLASK----LPAGIGYDWTGMSYQERLSGNQAPA- 874 Query: 337 EALIAAVLTAMMILLFL-GNWRSTLIIAISIPLSIFTSLIALSALGETINIMTLGGLALA 395 + + + + L L +W + + + +PL I L+A + + ++ + GL Sbjct: 875 -LVAISFVVVFLCLAALYESWSIPVSVMLVVPLGIVGVLLAATLFNQKNDVYFMVGLLTT 933 Query: 396 VGILVDDATVTIENI-ERHLHLGTNLHDAILEGAGEIAVPALVSTLCICIVFVPMFFLTG 454 +G+ +A + +E + G + +A L P L+++L + +P+ G Sbjct: 934 IGLSAKNAILIVEFAKDLMEKEGKGVVEATLMAVRMRLRPILMTSLAFILGVLPLAISNG 993 Query: 455 VARFLFVPLAEAVVFAMLASYVLSRTLVPTLAMLLFR 491 + V+ M+++ +L+ VP +++ R Sbjct: 994 AGSGAQNAVGIGVMGGMVSATLLAIFFVPVFFVVIRR 1030
>cloacin#Cloacin signature. Length = 551 Score = 32.4 bits (73), Expect = 0.004 Identities = 21/82 (25%), Positives = 34/82 (41%) Query: 44 SGTNGTSGTSGASGSSGTSGSSGTSGSSGTSGTSGTSGTSGTSGTSGTSGTSGTSGTSGT 103 SG +G +GA +SG T G + G+ +S + G SG+ G Sbjct: 2 SGGDGRGHNTGAHSTSGNINGGPTGLGVGGGASDGSGWSSENNPWGGGSGSGIHWGGGSG 61 Query: 104 SGTSGTSGTSGTSGTSGTSGTS 125 G G +G SG +G + ++ Sbjct: 62 HGNGGGNGNSGGGSGTGGNLSA 83 Score = 30.8 bits (69), Expect = 0.011 Identities = 21/76 (27%), Positives = 32/76 (42%) Query: 26 GGDITAPTLAGNNIGTSTSGTNGTSGTSGASGSSGTSGSSGTSGSSGTSGTSGTSGTSGT 85 G + A + +GN G T G + G+ SS + G SGS G G G Sbjct: 8 GHNTGAHSTSGNINGGPTGLGVGGGASDGSGWSSENNPWGGGSGSGIHWGGGSGHGNGGG 67 Query: 86 SGTSGTSGTSGTSGTS 101 +G SG +G + ++ Sbjct: 68 NGNSGGGSGTGGNLSA 83
>TCRTETB#Tetracycline resistance protein TetB signature. Length = 458 Score = 142 bits (360), Expect = 8e-40 Identities = 92/412 (22%), Positives = 173/412 (41%), Gaps = 18/412 (4%) Query: 7 HSVLLWIVAAAFFMQSLDTTIVNTALPSIAQSLHASPLAMQPVVVVYTLTMAMLTPASGW 66 + +L+W+ +FF L+ ++N +LP IA + P + V + LT ++ T G Sbjct: 13 NQILIWLCILSFF-SVLNEMVLNVSLPDIANDFNKPPASTNWVNTAFMLTFSIGTAVYGK 71 Query: 67 LADRFGTRRVFSVAILVFVLASIGCAASHTLGQ-LVVARAVQGIGGSMLLPIGRLAVLRR 125 L+D+ G +R+ I++ S+ H+ L++AR +QG G + + + V R Sbjct: 72 LSDQLGIKRLLLFGIIINCFGSVIGFVGHSFFSLLIMARFIQGAGAAAFPALVMVVVARY 131 Query: 126 VPGEQYVAAIAFVSIAGQLGPIVGPTLGGWLTQAISWHWVFIVNVPVGVVGFIAVQRYLP 185 +P E A + +G VGP +GG + I HW +++ +P+ + + L Sbjct: 132 IPKENRGKAFGLIGSIVAMGEGVGPAIGGMIAHYI--HWSYLLLIPMITIITVPFLMKLL 189 Query: 186 HDQATQPPPFDFVGCALLSAAMIALSLAIDPPMSTHRAAWSAALAGLGLASALAYLPHAR 245 + FD G L+S ++ L + + L ++ H R Sbjct: 190 KKEVRIKGHFDIKGIILMSVGIVFFMLFTTSYSISFLIVSVLSF--------LIFVKHIR 241 Query: 246 RRTQPLFRLGLFREPNFGSGLLGNLLCRIGTSSVPFMLPLLMQVQLGYTPLRSG-LMMLP 304 + T P GL + F G+L + + M+P +M+ + G +++ P Sbjct: 242 KVTDPFVDPGLGKNIPFMIGVLCGGIIFGTVAGFVSMVPYMMKDVHQLSTAEIGSVIIFP 301 Query: 305 AAIAGVIAKRWIAPLVKRFG--YAAFLVVNTGIVGCAIAGFALVSARPAPVLEGVLLIVF 362 ++ +I LV R G Y + V V A F L + + +++ V Sbjct: 302 GTMSVIIFGYIGGILVDRRGPLYVLNIGVTFLSVSFLTASFLLETTSWFMTI--IIVFVL 359 Query: 363 GAANSMQFAAMNGVTLKGLSHADAGSGNSLFTMMQMLAMGLGVSIGGGLVNL 414 G + + + + L +AG+G SL L+ G G++I GGL+++ Sbjct: 360 GGLSFTKTVI-STIVSSSLKQQEAGAGMSLLNFTSFLSEGTGIAIVGGLLSI 410
>PF05272#Virulence-associated E family protein Length = 892 Score = 29.3 bits (65), Expect = 0.031 Identities = 26/145 (17%), Positives = 44/145 (30%), Gaps = 9/145 (6%) Query: 238 RDANGHERWW-LDVTGKGGRQRLVPATDEMMAE-LTRYRRTHGLPALPLDGEPTPLVLPF 295 D G+ R+W + V G+ L ++ AE L Y P D E Sbjct: 700 FDITGNRRFWPVLVPGRANLVWLQKFRGQLFAEALHLYLAGERYFPSPEDEEIYFRP--- 756 Query: 296 GQARKPLTRAALHRIVKQVFRHAAGRLRANGETGEQAARVLEQ----ASAHWLRHSAGSH 351 Q + + R+ + R A + G A S Sbjct: 757 EQELRLVETGVQGRLWALLTREGAPAAEGAAQKGYSVNTTFVTIADLVQALGADPGKSSP 816 Query: 352 MADGRVDLRLVRDNLGHVSLTTTSQ 376 M +G+V L + ++ T+ + Sbjct: 817 MLEGQVRDWLNENGWEYLRETSGQR 841
>TCRTETA#Tetracycline resistance protein signature. Length = 399 Score = 38.3 bits (89), Expect = 4e-05 Identities = 69/312 (22%), Positives = 116/312 (37%), Gaps = 28/312 (8%) Query: 40 PLMPLIAREFHLTAAQVANINI--AAVAAT-IAVRLLVGPLCDRFGPRRVYAGLLLLGAI 96 P++P + R+ + A+ I A A A ++G L DRFG R V L A+ Sbjct: 26 PVLPGLLRDLVHSNDVTAHYGILLALYALMQFACAPVLGALSDRFGRRPVLLVSLAGAAV 85 Query: 97 PVFAVSFTHDYLWFLICRLGIGAIGA-GFVITQYHTSVMFAPNVVGTANATTAGWGNAGA 155 ++ I R+ G GA G V Y A G A G+ +A Sbjct: 86 DYAIMATAPFLWVLYIGRIVAGITGATGAVAGAY-----IADITDGDERARHFGFMSACF 140 Query: 156 GATQALMPLLVAAGLMLGFGEDSSWRIALVVPGVAMLAMAWAYWRFTQDCPQGDFVALRK 215 G P+L GLM GF + + A + G+ L + + +G+ LR+ Sbjct: 141 GFGMVAGPVL--GGLMGGFSPHAPFFAAAALNGLNFLTGCF----LLPESHKGERRPLRR 194 Query: 216 QGVTVDSGKKGGWASFFRACGNYRVWMLFVTYGACFGVEVFIHNIAALYYVDHFKLSLKD 275 + + + + WA ++ V + +V + ++ D F Sbjct: 195 EALNPLASFR--WARGMTVVA----ALMAVFFIMQLVGQVPA-ALWVIFGEDRFHWDATT 247 Query: 276 AGFAVGMFGLLALFARALGGWLSDKIAARRSLDVRATLLCALIIGEGLGLIWFSHAQGIG 335 G ++ FG+L A+A+ ++ +AAR L +I +G G I + A Sbjct: 248 IGISLAAFGILHSLAQAM---ITGPVAARLG---ERRALMLGMIADGTGYILLAFATRGW 301 Query: 336 MALVAMLTFGLF 347 MA M+ Sbjct: 302 MAFPIMVLLASG 313
>HTHFIS#FIS bacterial regulatory protein HTH signature. Length = 484 Score = 45.6 bits (108), Expect = 6e-08 Identities = 33/156 (21%), Positives = 54/156 (34%), Gaps = 7/156 (4%) Query: 29 TRLRVLLVTDTDKPIGELGDALARLGYEMLNDVATPARLPAAVEEQRPDVVIIDTDSPSR 88 T +L+ D L AL+R GY++ + A L + D+V+ D P Sbjct: 2 TGATILVADDDAAIRTVLNQALSRAGYDVRI-TSNAATLWRWIAAGDGDLVVTDVVMPDE 60 Query: 89 DTLEQLAVMHATAPR-PVLMFSHDADQELIRAAVGAGVSAYLVEGLSAERLAPILEVALA 147 + + L + P PVL+ S A G YL + L I+ ALA Sbjct: 61 NAFDLLPRIKKARPDLPVLVMSAQNTFMTAIKASEKGAYDYLPKPFDLTELIGIIGRALA 120 Query: 148 RFSHDDALRRRLADVEREL-----AERKLIDRAKRV 178 + + L A +++ R+ Sbjct: 121 EPKRRPSKLEDDSQDGMPLVGRSAAMQEIYRVLARL 156
>TCRTETA#Tetracycline resistance protein signature. Length = 399 Score = 57.5 bits (139), Expect = 3e-11 Identities = 68/280 (24%), Positives = 109/280 (38%), Gaps = 17/280 (6%) Query: 43 TLIVLCALSVLPLSLFLPSLPAIVRDLHTDYALVA---LSLGGYAAVAASLECVTGPLSD 99 ++ AL + + L +P LP ++RDL + A + L YA + + V G LSD Sbjct: 9 VILSTVALDAVGIGLIMPVLPGLLRDLVHSNDVTAHYGILLALYALMQFACAPVLGALSD 68 Query: 100 RFGRRPIVLTSVALFALGSLGCAMATDIHVFLGCRLMQAAITSVYPVSMAAIRDTDGGAR 159 RFGRRP++L S+A A+ A A + V R++ + V+ A I D G Sbjct: 69 RFGRRPVLLVSLAGAAVDYAIMATAPFLWVLYIGRIVAGITGATGAVAGAYIADITDGDE 128 Query: 160 AASRIGYAAMAAAFAPMLGPTLGGALDQTVGWRASFWLLAVVGTALFAWCVRDLAETHTR 219 A G+ + F + GP LGG + A F+ A + F L E+H Sbjct: 129 RARHFGFMSACFGFGMVAGPVLGGLMGG-FSPHAPFFAAAALNGLNFLTGCFLLPESHKG 187 Query: 220 RPSSFGQQLRAYPALLRARRFWAYALCMAFSTGAFYAFLAGAPLAATTLFGI-----PPA 274 ++ A R R + + + P A +FG Sbjct: 188 ERRPLRREALNPLASFRWARGMT-VVAALMAVFFIMQLVGQVPAALWVIFGEDRFHWDAT 246 Query: 275 EIGF------YMGTITAGFVCGSFLAARVARRHALATTIL 308 IG + ++ + G +AAR+ R AL ++ Sbjct: 247 TIGISLAAFGILHSLAQAMITG-PVAARLGERRALMLGMI 285
>V8PROTEASE#V8 serine protease family signature. Length = 336 Score = 60.8 bits (147), Expect = 3e-12 Identities = 31/157 (19%), Positives = 55/157 (35%), Gaps = 26/157 (16%) Query: 151 SGSGSGFIVSADGLILTSAHVVDEATDVTVRLTDRR-----------EFKAT-VLAVDPQ 198 + SG +V +LT+ HVVD L F A + + Sbjct: 101 TFIASGVVV-GKDTLLTNKHVVDATHGDPHALKAFPSAINQDNYPNGGFTAEQITKYSGE 159 Query: 199 SDVAVLRVDATK--------LPFVRIGDSSKVRAGEPVMTIGAPDGSGNTVTAGIVSATS 250 D+A+++ + + + ++++ + + + G P G T Sbjct: 160 GDLAIVKFSPNEQNKHIGEVVKPATMSNNAETQVNQNITVTGYP-GDKPVATMWESKGKI 218 Query: 251 RRLPDGSAFPFFETDIAPNPDNSGGPVFNRAGDVIGI 287 L + D++ NSG PVFN +VIGI Sbjct: 219 TYLKG----EAMQYDLSTTGGNSGSPVFNEKNEVIGI 251
>SACTRNSFRASE#Streptothricin acetyltransferase signature. Length = 173 Score = 40.3 bits (94), Expect = 3e-06 Identities = 20/63 (31%), Positives = 29/63 (46%), Gaps = 2/63 (3%) Query: 336 RSCWTEGPYCYLQDLYTAPDARGQGAGGALIEAVYERAREAGASRVYWLTHETNTTARAL 395 RS W Y ++D+ A D R +G G AL+ E A+E + T + N +A Sbjct: 83 RSNWNG--YALIEDIAVAKDYRKKGVGTALLHKAIEWAKENHFCGLMLETQDINISACHF 140 Query: 396 YDK 398 Y K Sbjct: 141 YAK 143
>TCRTETB#Tetracycline resistance protein TetB signature. Length = 458 Score = 60.3 bits (146), Expect = 5e-12 Identities = 50/211 (23%), Positives = 83/211 (39%), Gaps = 7/211 (3%) Query: 51 IGLPSLQHEFGGSFASLSGIMSVFPFVGVFGGIAAGLLVRRWGDRRLLVTGLVILGLSSV 110 + LP + ++F AS + + + F G G L + G +RLL+ G++I SV Sbjct: 35 VSLPDIANDFNKPPASTNWVNTAFMLTFSIGTAVYGKLSDQLGIKRLLLFGIIINCFGSV 94 Query: 111 AGAWAGSFA-LLLATRFAEGLGFVIVVVAAPAVLNRVTPPERRNFAFGLWSTFMPAGMAL 169 G SF LL+ RF +G G V+ R P E R AFGL + + G Sbjct: 95 IGFVGHSFFSLLIMARFIQGAGAAAFPALVMVVVARYIPKENRGKAFGLIGSIVAMGEG- 153 Query: 170 SMLVGPLLGGWRNGWLAAAALTLVAAAAVPVTTSADAPSRQATTRIGP--ALRAVLASRS 227 VGP +GG ++ + L L+ + ++ G +L S Sbjct: 154 ---VGPAIGGMIAHYIHWSYLLLIPMITIITVPFLMKLLKKEVRIKGHFDIKGIILMSVG 210 Query: 228 TTLLALGFATYNVQFFAVMTFLPVFLMQRLS 258 L +Y++ F V + ++ + Sbjct: 211 IVFFMLFTTSYSISFLIVSVLSFLIFVKHIR 241
>SACTRNSFRASE#Streptothricin acetyltransferase signature. Length = 173 Score = 37.2 bits (86), Expect = 2e-05 Identities = 19/91 (20%), Positives = 34/91 (37%), Gaps = 13/91 (14%) Query: 152 NPAAFLFAHRLD----GQIAATARY-GFASPRDIVVDRVGTADAYRRRGLATQLLAAIVA 206 F + L+ G+I + + G+A DI V + YR++G+ T LL + Sbjct: 62 EEGKAAFLYYLENNCIGRIKIRSNWNGYALIEDIAVAK-----DYRKKGVGTALLHKAIE 116 Query: 207 HARHRGARRVWLISTEAGQP---LYRAAGFT 234 A+ + L + + Y F Sbjct: 117 WAKENHFCGLMLETQDINISACHFYAKHHFI 147
>OMADHESIN#Yersinia outer membrane adhesin signature. Length = 455 Score = 29.1 bits (64), Expect = 0.013 Identities = 15/43 (34%), Positives = 19/43 (44%) Query: 100 EPDGPGGGDTPVKPIDANAIMTRAFFPLTVPLTVGPGSIATAI 142 G GG + K I + AI A + VG GSIAT + Sbjct: 56 PVPGAGGLNASAKGIHSIAIGATAEAAKGAAVAVGAGSIATGV 98
>HTHFIS#FIS bacterial regulatory protein HTH signature. Length = 484 Score = 79.9 bits (197), Expect = 2e-19 Identities = 28/124 (22%), Positives = 50/124 (40%) Query: 25 AHVLTIEDDEITANEIVTELEGRGFTVEWVANGRDGMARALGNEFDVITLDRMLPVVDGL 84 A +L +DD + L G+ V +N + D++ D ++P + Sbjct: 4 ATILVADDDAAIRTVLNQALSRAGYDVRITSNAATLWRWIAAGDGDLVVTDVVMPDENAF 63 Query: 85 AILTTMRSVGVRTPVLMLSALGDVDERVRGLRAGGDDYLTKPFDPEEMAARLEVLLRRSQ 144 +L ++ PVL++SA ++ G DYL KPFD E+ + L + Sbjct: 64 DLLPRIKKARPDLPVLVMSAQNTFMTAIKASEKGAYDYLPKPFDLTELIGIIGRALAEPK 123 Query: 145 AAPA 148 P+ Sbjct: 124 RRPS 127
>ECOLNEIPORIN#E.coli/Neisseria porin superfamily signature. Length = 331 Score = 103 bits (258), Expect = 6e-27 Identities = 72/343 (20%), Positives = 123/343 (35%), Gaps = 52/343 (15%) Query: 15 PALLLAGTAHAQQSITLYGLIDEGLNFTSNAGGHRAWQMSSGDT-----FGSRWGLKGSE 69 AL +A A +TLYG I G+ + + + A S GS+ G KG E Sbjct: 11 AALPVAAMA----DVTLYGTIKAGVETSRSVAHNGAQAASVETGTGIVDLGSKIGFKGQE 66 Query: 70 DLGGGDKAIFQLENGFNVNSGKLGQDSSMFGRQAFVGLSSSRYGTLTLGRQYDTSVDALG 129 DLG G KAI+Q+E ++ G DS RQ+F+GL +G L +GR D Sbjct: 67 DLGNGLKAIWQVEQKASIA----GTDSGWGNRQSFIGLKGG-FGKLRVGRLNSVLKDTGD 121 Query: 130 FGGITAAGNWAGDIATHPFDNDNTDWDFRVNNAVKYVTPTYRGLTAEAMYGFSNQPGGFS 189 + ++ G + +V+Y +P + GL+ Y ++ G Sbjct: 122 INPWDSKSDYLGVNKIAEPEARLI--------SVRYDSPEFAGLSGSVQYALNDN-AGRH 172 Query: 190 NNRVWGATLNYQSGNLTAAASYLKLNNPGLAAGGAVNSGDLFNGSSQQDIGVAASYQFTH 249 N+ + A NY++G + + N Q + + Y Sbjct: 173 NSESYHAGFNYKNGGFFVQYGGAYKRHH--------QVQENVNIEKYQIHRLVSGY---- 220 Query: 250 VLVGAAWSHVDVYNPAGNAWIDNTALQNGATWNAWKFDNFELNAQYYFTHALWLGASYTF 309 + V +A ++ + N+ E+ A + + + Sbjct: 221 ---DNDALYASVAVQQQDA----KLVEENYSHNS----QTEVAATLAYR---FGNVTPRV 266 Query: 310 TIAHLYTSDTKYV---PKWHQIGMMLDYDLSKRTSLYLQGAWQ 349 + AH + + Q+ + +YD SKRTS + W Sbjct: 267 SYAHGFKGSFDATNYNNDYDQVVVGAEYDFSKRTSALVSAGWL 309
>ECOLNEIPORIN#E.coli/Neisseria porin superfamily signature. Length = 331 Score = 208 bits (532), Expect = 4e-67 Identities = 97/373 (26%), Positives = 147/373 (39%), Gaps = 53/373 (14%) Query: 1 MNKTLIVAAAAASFATVAHAQSSVTLYGVLDAGITYQSNVGGKSLWS----MGSGIDQ-- 54 M K+LI AA A + VTLYG + AG+ +V + G+GI Sbjct: 1 MKKSLIALTLAA---LPVAAMADVTLYGTIKAGVETSRSVAHNGAQAASVETGTGIVDLG 57 Query: 55 SRFGLRGSEDLGGGLKAIFTLESGFNIGNGRFANGNGGMFNRQAFVGLSSQYGTVTLGKQ 114 S+ G +G EDLG GLKAI+ +E +I A + G NRQ+F+GL +G + +G+ Sbjct: 58 SKIGFKGQEDLGNGLKAIWQVEQKASI-----AGTDSGWGNRQSFIGLKGGFGKLRVGRL 112 Query: 115 YDATQDY--LAPLTATGSW-GGTYFAHPLNNDRLSTNGDVALNNSIKYTSANYAGLQFGG 171 +D + P + + G A P RL S++Y S +AGL Sbjct: 113 NSVLKDTGDINPWDSKSDYLGVNKIAEP--EARLI---------SVRYDSPEFAGLSGSV 161 Query: 172 TYSFSNNTNFGNNRAYSGGLSYQFQGLKLGAAYSQANLGDGTNTNGASTLGGQGRVRTYG 231 Y+ ++N N+ +Y G +Y+ G + + V Y Sbjct: 162 QYALNDNAGRHNSESYHAGFNYKNGGFFVQYGGAYKRHHQVQENVNIEKYQIHRLVSGYD 221 Query: 232 AAAGYAFGPAQVGAA--WTQSRIDNQAAGVPTLRADNYEVNAKYNLTPALGLGAAYTYTN 289 A YA Q A ++ N V A + N ++ A G ++ T Sbjct: 222 NDALYASVAVQQQDAKLVEENYSHNSQTEVAATLAYRFG-NVTPRVSYAHGFKGSFDAT- 279 Query: 290 AKVNNGSSHWNQFGVQADYALSKRTDVYAQAVYQRGAKGNNIVGTGIYNGDNTTASSSSV 349 N ++ ++Q V A+Y SKRT A + + KG S Sbjct: 280 ----NYNNDYDQVVVGAEYDFSKRTSALVSAGWLQEGKG-----------------ESKF 318 Query: 350 NQTAATVGLRHRF 362 TA VGLRH+F Sbjct: 319 VSTAGGVGLRHKF 331
>DHBDHDRGNASE#2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase signature. Length = 261 Score = 103 bits (258), Expect = 1e-28 Identities = 67/250 (26%), Positives = 98/250 (39%), Gaps = 7/250 (2%) Query: 7 RTIAITGAGTGIGAACARRFARRGDRVVLIGRRQAPLDALAAETGGLA-----LAGDAAS 61 + ITGA GIG A AR A +G + + L+ + + A D Sbjct: 9 KIAFITGAAQGIGEAVARTLASQGAHIAAVDYNPEKLEKVVSSLKAEARHAEAFPADVRD 68 Query: 62 PADWAGFVQRIAERFGRVDALVACAGGHGIGRADETDDAQWRDAMHANLDTAFVSARACL 121 A RI G +D LV AG G D +W N F ++R+ Sbjct: 69 SAAIDEITARIEREMGPIDILVNVAGVLRPGLIHSLSDEEWEATFSVNSTGVFNASRSVS 128 Query: 122 PDLIAQR-GNIVLVASIAALAAGPGVCGYTVGKHALLGLARSLARDYGPHGVRANAVCPG 180 ++ +R G+IV V S A + Y K A + + L + + +R N V PG Sbjct: 129 KYMMDRRSGSIVTVGSNPAGVPRTSMAAYASSKAAAVMFTKCLGLELAEYNIRCNIVSPG 188 Query: 181 WVRTPMADAEMAPLMAAHDDSLDGAYARVSADVPLRRAADPDEIAAVCAFLASPDASFVT 240 T M + A A + + G+ +PL++ A P +IA FL S A +T Sbjct: 189 STETDMQWSLWADENGA-EQVIKGSLETFKTGIPLKKLAKPSDIADAVLFLVSGQAGHIT 247 Query: 241 GATLVADGGA 250 L DGGA Sbjct: 248 MHNLCVDGGA 257
>TCRTETA#Tetracycline resistance protein signature. Length = 399 Score = 32.5 bits (74), Expect = 0.003 Identities = 26/82 (31%), Positives = 32/82 (39%), Gaps = 6/82 (7%) Query: 247 LLIAGGSRIGSDVLYALIVVFTLTYVTTVLHLSRPVALTAVMIGTACNALAVPFFGALSD 306 L A G + VL L+ + H +AL A+M P GALSD Sbjct: 15 ALDAVGIGLIMPVLPGLLRDLVHS-NDVTAHYGILLALYALM-----QFACAPVLGALSD 68 Query: 307 RFGRRPVYLAGAIAGIVWAFVF 328 RFGRRPV L V + Sbjct: 69 RFGRRPVLLVSLAGAAVDYAIM 90
>NUCEPIMERASE#Nucleotide sugar epimerase signature. Length = 334 Score = 43.6 bits (103), Expect = 6e-07 Identities = 42/203 (20%), Positives = 75/203 (36%), Gaps = 37/203 (18%) Query: 13 LVLGASGGIGGEVARQLRDAGWQVRA-----------LKRGLDAEVVERDGIAWVRGDAL 61 LV GA+G IG V+++L +AG QV LK+ E++ + G + + D Sbjct: 4 LVTGAAGFIGFHVSKRLLEAGHQVVGIDNLNDYYDVSLKQA-RLELLAQPGFQFHKIDLA 62 Query: 62 DRDAVVRAAR--GCSVIVHAVNPPGYR----NWATQVLPMID---NTIAAARAAQ-ATVV 111 DR+ + + + + R N + N + R + ++ Sbjct: 63 DREGMTDLFASGHFERVFISPHRLAVRYSLENPHAYADSNLTGFLNILEGCRHNKIQHLL 122 Query: 112 LPGTVYNFGADA-FPVLREDAPQHPATRKGAIRVELERRLQDASA-HGVPAIVVRAGDFF 169 + +G + P +D+ HP + A + E S +G+PA +R + Sbjct: 123 YASSSSVYGLNRKMPFSTDDSVDHPVSLYAATKKANELMAHTYSHLYGLPATGLRFFTVY 182 Query: 170 GPQLGNSWFSQGLVKAGRPVAAI 192 GP GRP A+ Sbjct: 183 GP-------------WGRPDMAL 192
>PF05616#Neisseria meningitidis TspB protein Length = 501 Score = 27.8 bits (61), Expect = 0.007 Identities = 15/40 (37%), Positives = 17/40 (42%) Query: 57 TTPTPEPPADPNRDPEDDPFSSPPGHHDNPQQPDGPPSKD 96 T P PEP D N D D P D+P PD P + Sbjct: 349 TRPNPEPDPDLNPDANPDTDGQPGTRPDSPAVPDRPNGRH 388
>DHBDHDRGNASE#2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase signature. Length = 261 Score = 117 bits (293), Expect = 5e-34 Identities = 76/255 (29%), Positives = 119/255 (46%), Gaps = 25/255 (9%) Query: 2 LVTGASSGIGRACAVALAQAGARVVAAGRDMAALDTLAGEIAC-----DTLRLDVGGDQH 56 +TGA+ GIG A A LA GA + A + L+ + + + DV D Sbjct: 12 FITGAAQGIGEAVARTLASQGAHIAAVDYNPEKLEKVVSSLKAEARHAEAFPADVR-DSA 70 Query: 57 AIDAALAAYDA----FDGLVNCAGIASLEPALEVCAAQFDHVMAVNARGAALVARAVARK 112 AID A + D LVN AG+ + +++ +VN+ G +R+V++ Sbjct: 71 AIDEITARIEREMGPIDILVNVAGVLRPGLIHSLSDEEWEATFSVNSTGVFNASRSVSKY 130 Query: 113 MIERDGRGAAHARGSIVNVSSQAALVGLPAHLSYCASKAAMDAITRVLCIELGPHGIRVN 172 M++R GSIV V S A V + +Y +SKAA T+ L +EL + IR N Sbjct: 131 MMDRRS-------GSIVTVGSNPAGVPRTSMAAYASSKAAAVMFTKCLGLELAEYNIRCN 183 Query: 173 SVNPTVTLTPMAQFAWSEPEKRAPMLA--------AIPLGRFAEPHEVVEPILFLLSDAA 224 V+P T T M W++ ++ IPL + A+P ++ + +LFL+S A Sbjct: 184 IVSPGSTETDMQWSLWADENGAEQVIKGSLETFKTGIPLKKLAKPSDIADAVLFLVSGQA 243 Query: 225 SMISGVSLPIDGGYT 239 I+ +L +DGG T Sbjct: 244 GHITMHNLCVDGGAT 258
>NUCEPIMERASE#Nucleotide sugar epimerase signature. Length = 334 Score = 29.8 bits (67), Expect = 0.013 Identities = 18/64 (28%), Positives = 27/64 (42%), Gaps = 13/64 (20%) Query: 1 MRILVVG-AGAVGGYFGGRLVAAGRDVTFL----------VRDGRAAALARDGLLIRSPR 49 M+ LV G AG +G + RL+ AG V + ++ R LA+ G + Sbjct: 1 MKYLVTGAAGFIGFHVSKRLLEAGHQVVGIDNLNDYYDVSLKQARLELLAQPGFQFH--K 58 Query: 50 GDLT 53 DL Sbjct: 59 IDLA 62
>HTHFIS#FIS bacterial regulatory protein HTH signature. Length = 484 Score = 28.6 bits (64), Expect = 0.022 Identities = 12/61 (19%), Positives = 27/61 (44%), Gaps = 3/61 (4%) Query: 34 VAVYRSAAELVASLGGVDCDIVLVDYAIRGDEQMDGLALFDWLRRMRPNVGIVALVANEN 93 V + +AA L + D D+V+ D + + L +++ RP++ ++ + A Sbjct: 30 VRITSNAATLWRWIAAGDGDLVVTD--VV-MPDENAFDLLPRIKKARPDLPVLVMSAQNT 86 Query: 94 P 94 Sbjct: 87 F 87
>HTHFIS#FIS bacterial regulatory protein HTH signature. Length = 484 Score = 357 bits (919), Expect = e-121 Identities = 145/466 (31%), Positives = 211/466 (45%), Gaps = 48/466 (10%) Query: 39 AALVDVLASRGWDVWRAKTVADALNLVKANRPHAGIVDFGSFASPDVASFEAL----LRD 94 L L+ G+DV A + A + D PD +F+ L Sbjct: 17 TVLNQALSRAGYDVRITSNAATLWRWIAAGDGDLVVTDV---VMPDENAFDLLPRIKKAR 73 Query: 95 PRVGWVALADGERLRNITIARLIRHCCFDYVRNAGAYTTIGYLVGHAYGMLKLADGDPAA 154 P + + ++ A +DY+ T + ++G A K Sbjct: 74 PDLPVLVMSAQNTFMTAIKA--SEKGAYDYLPKPFDLTELIGIIGRALAEPK-RRPSKLE 130 Query: 155 EAPPPGGTMIGACGAMRRLFATIRKVANTEATVFIAGESGTGKELTAAAIHRQSSRADAP 214 + G ++G AM+ ++ + ++ T+ T+ I GESGTGKEL A A+H R + P Sbjct: 131 DDSQDGMPLVGRSAAMQEIYRVLARLMQTDLTLMITGESGTGKELVARALHDYGKRRNGP 190 Query: 215 FVAVNCAAIPTTLLQAELFGHERGAFTGAHQRKIGRIEAAHGGTLFLDEIGDMPFESQAS 274 FVA+N AAIP L+++ELFGHE+GAFTGA R GR E A GGTLFLDEIGDMP ++Q Sbjct: 191 FVAINMAAIPRDLIESELFGHEKGAFTGAQTRSTGRFEQAEGGTLFLDEIGDMPMDAQTR 250 Query: 275 LLRFLQEGKIERLGGHASIPVDVRIVSATHVDLEAAMQAGRFRADLYYRLCVLRIDEPPL 334 LLR LQ+G+ +GG I DVRIV+AT+ DL+ ++ G FR DLYYRL V+ + PPL Sbjct: 251 LLRVLQQGEYTTVGGRTPIRSDVRIVAATNKDLKQSINQGLFREDLYYRLNVVPLRLPPL 310 Query: 335 RMRGRDIMLLADDVLRRYRDDGSYRIRGFTPCAIEAIHNYPWPGNVRELINRIRFAVVMT 394 R R DI L +++ +G ++ F A+E + +PWPGNVREL N +R + Sbjct: 311 RDRAEDIPDLVRHFVQQAEKEG-LDVKRFDQEALELMKAHPWPGNVRELENLVRRLTALY 369 Query: 395 NGPLISAADLELR-------------------------------------PYTSLRPPTL 417 +I+ +E Sbjct: 370 PQDVITREIIENELRSEIPDSPIEKAAARSGSLSISQAVEENMRQYFASFGDALPPSGLY 429 Query: 418 AQARRQAERHAIEETLLRHRHQHADVAAELGISRATLYRLMIAHGL 463 + + E I L R A LG++R TL + + G+ Sbjct: 430 DRVLAEMEYPLILAALTATRGNQIKAADLLGLNRNTLRKKIRELGV 475
>IGASERPTASE#IgA-specific serine endopeptidase (S6) signature. Length = 1541 Score = 47.8 bits (113), Expect = 1e-07 Identities = 46/259 (17%), Positives = 72/259 (27%), Gaps = 13/259 (5%) Query: 306 PTVAAAVPVAAAPAAAAPAVAAAPAASVVPAAAMAAVPAAAVIAAPAVADKAAPAPAAPV 365 P V P A SV A A + PA A + Sbjct: 983 PEVEKRNQTVDTTNITTPNNIQADVPSVPSNNEEIARVDEAPVPPPAPATPSETTETVAE 1042 Query: 366 ADTKAAEPVQPVVDKAAEPAPTVADKAPEAAPAVADKTPEPAPAVADKAPEPAQPVADKA 425 + ++ V+ A E + A EA V T A + + Q K Sbjct: 1043 NSKQESKTVEKNEQDATETTAQNREVAKEAKSNVKANTQTNEVAQSGSETKETQTTETKE 1102 Query: 426 PEPMPAA------TDTAQAVGEPVAE--PMPAAAVVAAPAADAKAAEPAPQATAEAPAPA 477 + T+ Q V + ++ P + P A+ A E P + P Sbjct: 1103 TATVEKEEKAKVETEKTQEVPKVTSQVSPKQEQSETVQPQAEP-ARENDPTVNIKEPQSQ 1161 Query: 478 APQPAVAAAPADMPAADAKVPDAVESAGTAAAQAAGMPALTDPAQALPPATVDKQAAP-- 535 A PA +++ + P + P T PA P + P Sbjct: 1162 TNTTADTEQPAKETSSNVEQPVTESTTVNTGNSVVENPENTTPATTQPTVNSESSNKPKN 1221 Query: 536 --AAPVAPAPTVISTSTSS 552 V P + +T+S Sbjct: 1222 RHRRSVRSVPHNVEPATTS 1240 Score = 46.6 bits (110), Expect = 3e-07 Identities = 75/514 (14%), Positives = 145/514 (28%), Gaps = 54/514 (10%) Query: 28 STSSAQSSTSSTAISQGGGSSMNTNTTSSRGGNATSSSGVRGSGNSSVNVN----VTMPS 83 S ++ S + G ++ + G A ++ GNS V + + Sbjct: 800 DKLSDKALNSFNPTNLRGNVNLTESANFVLG-KANLFGTIQSRGNSQVRLTENSHWHLTG 858 Query: 84 STAGGNVTPQSTN---TLAAGAPGSSPYNTQATENVNYSGTQTIKTNPSIQAPGLTTTLS 140 ++ + + + A + + YNT +++ +G+ T+ S G ++ Sbjct: 859 NSDVHQLDLANGHIHLNSADNSNNVTKYNTLTVNSLSGNGSFYYLTDLS-NKQGDKVVVT 917 Query: 141 DTCMGSVSVGVS-FPGFGATGGTTLVDQACVRR-----------LDAREFRAMGLTDVAL 188 + G+ ++ V+ G TL D + +R +D ++ Sbjct: 918 KSATGNFTLQVADKTGEPNHNELTLFDASKAQRDHLNVSLVGNTVDLGAWKYKLRNVNGR 977 Query: 189 ALLCQSDA--NRRAVEATGHLCPGTTAPLARSNVAPSVEATVADDVKYRDPIVRDRMGLP 246 L + + V+ T T P PSV + + + D +P Sbjct: 978 YDLYNPEVEKRNQTVDTTN-----ITTPNNIQADVPSVPSNNEEIARV------DEAPVP 1026 Query: 247 PLGSAAPAPAATRPIETASMRAAPVSVPVPVPVPALAPVAAAPAVATPAVAAAAPAVAVP 306 P A P+ E + + V A A V A V Sbjct: 1027 PPAPATPSETTETVAENSKQESKTVEKNEQDATETTAQNREVAKEAKSNVKANTQTNEVA 1086 Query: 307 TVAAAVPVAAAPAAAAPAVAAAPAASVVPAAAMAAVPAAAVIAAPAVADKAAPAPAAPVA 366 + A V A V P V + +P Sbjct: 1087 QSGSET------KETQTTETKETAT--VEKEEKAKVETEKTQEVPKVTSQVSPKQEQSET 1138 Query: 367 DTKAAEPVQPVVDKAAEPAPTVADKAPEAAPAVADKTPEPAPAVADKAPEPAQPVADKAP 426 AEP A E PTV K P++ T +PA + QPV + Sbjct: 1139 VQPQAEP-------ARENDPTVNIKEPQSQTNTTADTEQPAKET---SSNVEQPVTESTT 1188 Query: 427 -EPMPAATDTAQAVGEPVAEPMPAAAVVAAPAADAKAAEPAPQATAEAPAPAAPQPAVAA 485 + + + +P + P + + + E ++ + Sbjct: 1189 VNTGNSVVENPENTTPATTQPTVNSESSNKPKNRHRRSVRSVPHNVEPATTSSNDRS-TV 1247 Query: 486 APADMPAADAKVPDAVESAGTAAAQAAGMPALTD 519 A D+ + + + A A++ Sbjct: 1248 ALCDLTSTNTNAVLSDARAKAQFVALNVGKAVSQ 1281
>cloacin#Cloacin signature. Length = 551 Score = 26.6 bits (58), Expect = 0.025 Identities = 22/69 (31%), Positives = 27/69 (39%), Gaps = 2/69 (2%) Query: 36 MAGVAGFGHFTATDSGSALGAAGATAGGGSSGSISYTNHTQTSTV--GGFGFGGAQAGGS 93 M+G G GH T S S G T G G+ + + + GG G G GGS Sbjct: 1 MSGGDGRGHNTGAHSTSGNINGGPTGLGVGGGASDGSGWSSENNPWGGGSGSGIHWGGGS 60 Query: 94 SGANAGSTG 102 N G G Sbjct: 61 GHGNGGGNG 69
>FLGMOTORFLIN#Flagellar motor switch protein FliN signature. Length = 137 Score = 54.5 bits (131), Expect = 2e-11 Identities = 25/73 (34%), Positives = 37/73 (50%), Gaps = 1/73 (1%) Query: 312 VDLRFELPPTSMPLGELSALQPGAVIELQQGINQSVIHLVANGMLIGTGHLIAVGQKLGV 371 V L EL T M + EL L G+V+ L + + ++ NG LI G ++ V K GV Sbjct: 62 VKLTVELGRTRMTIKELLRLTQGSVVALDGLAGEPL-DILINGYLIAQGEVVVVADKYGV 120 Query: 372 RVVTLTQPAPRER 384 R+ + P+ R R Sbjct: 121 RITDIITPSERMR 133 Score = 29.9 bits (67), Expect = 0.007 Identities = 17/57 (29%), Positives = 27/57 (47%), Gaps = 3/57 (5%) Query: 189 ALAVFFAAAPAALADARAAYANL---PVPLVFEIGRTELTTAELADVVGGDIIAIER 242 A AVF ++ A + PV L E+GRT +T EL + G ++A++ Sbjct: 35 ADAVFQQLGGGDVSGAMQDIDLIMDIPVKLTVELGRTRMTIKELLRLTQGSVVALDG 91
>TYPE3IMPPROT#Type III secretion system inner membrane P protein family signature. Length = 224 Score = 226 bits (578), Expect = 2e-77 Identities = 82/220 (37%), Positives = 129/220 (58%), Gaps = 10/220 (4%) Query: 6 NPVALIAVIAALGIAPFAALMVTSYTKLVVVLGLLRSALGIQQVPPNLVLNGIALILSLF 65 N ++LIA++A + PF T + K +V ++R+ALG+QQ+P N+ LNG+AL+LS+F Sbjct: 3 NDISLIALLAFSTLLPFIIASGTCFVKFSIVFVMVRNALGLQQIPSNMTLNGVALLLSMF 62 Query: 66 IMAPVGMSIRDALQARHFDASGQLSTSDIGALADAALPPIKDFLVSHTRQRDREFFVRTA 125 +M P+ + + S + D L +D+L+ ++ + +FF Sbjct: 63 VMWPIMHDAYVYFEDEDVTFNDI---SSLSKHVDEGLDGYRDYLIKYSDRELVQFFENAQ 119 Query: 126 TSVWPKNRA-------DGIKDDDLLVLVPSFTLAELTKAFQIGFVIYIVFIVVDLLVANI 178 D I+ + L+P++ L+E+ AF+IGF +Y+ F+VVDL+V+++ Sbjct: 120 LKRQYGEETETVKRDKDEIEKPSIFALLPAYALSEIKSAFKIGFYLYLPFVVVDLVVSSV 179 Query: 179 LLALGMQMISPTTISVPFKLLLFVALDGWSLLVHGLVLSY 218 LLALGM M+SP TIS P KL+LFVALDGW+LL GL+L Y Sbjct: 180 LLALGMMMMSPVTISTPIKLVLFVALDGWTLLSKGLILQY 219
>PF03544#Gram-negative bacterial tonB protein Length = 243 Score = 35.0 bits (80), Expect = 0.005 Identities = 12/67 (17%), Positives = 19/67 (28%) Query: 23 LVVAPPPPPPPPPKKDDPAAGPANPTAAPPIPVTASLATDPSKPTNAEIQSATSLIQSMA 82 VV P P P PK P+ + + + P +AT+ Sbjct: 91 PVVIEKPKPKPKPKPKPVKKVEQPKRDVKPVESRPASPFENTAPARPTSSTATAATSKPV 150 Query: 83 AQYTAPP 89 + P Sbjct: 151 TSVASGP 157
>TYPE3IMSPROT#Type III secretion system inner membrane S protein family signature. Length = 354 Score = 247 bits (633), Expect = 3e-82 Identities = 95/339 (28%), Positives = 175/339 (51%), Gaps = 3/339 (0%) Query: 2 AEKDQKPTAKRLREAREKGDVPKSAETVSSAFFVGVCVALAVGIGSLFARVQALFRLVFD 61 EK ++PT K++R+AR+KG V KS E VS+A V + L F L + + Sbjct: 3 GEKTEQPTPKKIRDARKKGQVAKSKEVVSTALIVALSAMLMGLSDYYFEHFSKLMLIPAE 62 Query: 62 AVGAADPSARLAALIDGAARDWATLSAQIVAAGLLAGLLAGFVQVGGVMAWSRLVPQLSR 121 S L+ ++D ++ L ++ L + + VQ G +++ + P + + Sbjct: 63 QSYL-PFSQALSYVVDNVLLEFFYLCFPLLTVAALMAIASHVVQYGFLISGEAIKPDIKK 121 Query: 122 LNPAEGMKNLWSLRNLVNLAKMLLKTALLVATLGWLIVESLDPSVQSGFTRPASILALIV 181 +NP EG K ++S+++LV K +LK LL + +I +L +Q I L+ Sbjct: 122 INPIEGAKRIFSIKSLVEFLKSILKVVLLSILIWIIIKGNLVTLLQLPTCGIECITPLLG 181 Query: 182 KLLMLLFGWAALIYIVMALIDIVHQRHEFNQKMKMSIDEVRREHKEDEGDPHIQAKRRQL 241 ++L L + ++V+++ D + +++ +++KMS DE++RE+KE EG P I++KRRQ Sbjct: 182 QILRQLMVICTVGFVVISIADYAFEYYQYIKELKMSKDEIKREYKEMEGSPEIKSKRRQF 241 Query: 242 AREAQFASLPDRIGYASVVVYSP-RVAVALYYG-GMGSLPWVLARGEGDAGERIVRLARD 299 +E Q ++ + + +SVVV +P +A+ + Y G LP V + + + ++A + Sbjct: 242 HQEIQSRNMRENVKRSSVVVANPTHIAIGILYKRGETPLPLVTFKYTDAQVQTVRKIAEE 301 Query: 300 ALRPTLANVGLAQALYETTPENGTIQPQHFRAVAQLLKW 338 P L + LA+ALY + I + A A++L+W Sbjct: 302 EGVPILQRIPLARALYWDALVDHYIPAEQIEATAEVLRW 340
>TYPE3IMRPROT#Type III secretion system inner membrane R protein family signature. Length = 261 Score = 133 bits (337), Expect = 4e-40 Identities = 61/248 (24%), Positives = 114/248 (45%), Gaps = 3/248 (1%) Query: 15 LRPLLYVMPRLLPIMFVVPVFNEQIITGLVRNGIAVVIAAFVAPTIDAAQVAALPFLMWC 74 L + + R+L ++ P+ +E+ + V+ G+A++I +AP++ A V F Sbjct: 13 LNLYFWPLLRVLALISTAPILSERSVPKRVKLGLAMMITFAIAPSLPANDVPVFSFF-AL 71 Query: 75 LLVAKEAMVGMLLAGAFSAVLFAIQGVGYLIDFQTGSGSAAFFDPMGGHEGGPTSGFLNF 134 L ++ ++G+ L A++ G +I Q G A F DP + ++ Sbjct: 72 WLAVQQILIGIALGFTMQFAFAAVRTAGEIIGLQMGLSFATFVDPASHLNMPVLARIMDM 131 Query: 135 VAIALFVTAGGLQVLVQLFAQSYAWWPIGSLGPDFSSMLQTFIVRQTDTIFEWMVKLAAP 194 +A+ LF+T G L+ L ++ PIG +S + + IF + LA P Sbjct: 132 LALLLFLTFNGHLWLISLLVDTFHTLPIGG--EPLNSNAFLALTKAGSLIFLNGLMLALP 189 Query: 195 VTIVLVLVELGVGLVGRAVPQLNIFVFSQPLKSALAVLMMILFLPVVYASLHSLLSPDSG 254 + +L+ + L +GL+ R PQL+IFV PL + + +M +P++ L S Sbjct: 190 LITLLLTLNLALGLLNRMAPQLSIFVIGFPLTLTVGISLMAALMPLIAPFCEHLFSEIFN 249 Query: 255 LMALLRAL 262 L+A + + Sbjct: 250 LLADIISE 257
>IGASERPTASE#IgA-specific serine endopeptidase (S6) signature. Length = 1541 Score = 34.3 bits (78), Expect = 4e-04 Identities = 13/100 (13%), Positives = 28/100 (28%) Query: 114 PKRKARAASKTVSGAGPKAAPKTAVKAAPKPASKSSTNPATKPATKPLSKPATKPATKPA 173 + V + PK + +PK + P +PA + K Sbjct: 1103 TATVEKEEKAKVETEKTQEVPKVTSQVSPKQEQSETVQPQAEPARENDPTVNIKEPQSQT 1162 Query: 174 TKPASAQKTKQAAKSTSKPASAQKPKPASKSSPAPAPKRV 213 A ++ + S + + + +S P+ Sbjct: 1163 NTTADTEQPAKETSSNVEQPVTESTTVNTGNSVVENPENT 1202
>ACRIFLAVINRP#Acriflavin resistance protein family signature. Length = 1034 Score = 24.0 bits (52), Expect = 0.048 Identities = 16/50 (32%), Positives = 27/50 (54%), Gaps = 8/50 (16%) Query: 9 LLISLVLVAIVVYPYVRIVRRTGHSGWWILTMFVPVLNFVMLWVFAFARW 58 L +++LV +V+Y +++ +R T I T+ VPV V+L FA Sbjct: 344 LFEAIMLVFLVMYLFLQNMRAT-----LIPTIAVPV---VLLGTFAILAA 385
>BLACTAMASEA#Beta-lactamase class A signature. Length = 286 Score = 372 bits (958), Expect = e-133 Identities = 119/270 (44%), Positives = 162/270 (60%), Gaps = 1/270 (0%) Query: 41 AAAAADAIAPAAAATTLADLERDAGGRLGVCAIDTASGR-IIEHRAGERFPFCSTFKAML 99 A A + E GR+G+ +D ASGR + RA ERFP STFK +L Sbjct: 13 ATLPLAVHASPQPLEQIKLSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVL 72 Query: 100 SAAVLAQSVERPGLLQQRVTYTKADLVNYSPVSEKHVGSGMTVAALCEAAIQYSDNSAAN 159 AVLA+ L++++ Y + DLV+YSPVSEKH+ GMTV LC AAI SDNSAAN Sbjct: 73 CGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAAN 132 Query: 160 LLMKLIGGPSAVTAYARSIGDDTFRLDRWETELNTALPGDPRDTTTPAAMAASLRVLTLG 219 LL+ +GGP+ +TA+ R IGD+ RLDRWETELN ALPGD RDTTTPA+MAA+LR L Sbjct: 133 LLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLTS 192 Query: 220 DALPAAQRAQLVAWLRGNKVGDKRIRAGVPAGWVVGDKTGTGDYGTTNDAGVIWPTSRAP 279 L A + QL+ W+ ++V IR+ +PAGW + DKTG G+ G ++ P ++A Sbjct: 193 QRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGAGERGARGIVALLGPNNKAE 252 Query: 280 IVLAVYYTQTRADARAKDDVIASVARIVAQ 309 ++ +Y T A ++ IA + + + Sbjct: 253 RIVVIYLRDTPASMAERNQQIAGIGAALIE 282
>INTIMIN#Intimin signature. Length = 939 Score = 43.1 bits (101), Expect = 2e-05 Identities = 66/279 (23%), Positives = 96/279 (34%), Gaps = 22/279 (7%) Query: 1648 STGAVNLAGTGATFDVSGATGTQTVGALSGAAGTNVNLGANALALNGSGSSTFGGTIGGA 1707 T A+ T V+ A + +SG A L AN+ NGSG +T Sbjct: 574 GTEAITYTATVKKNGVAQANVPVSFNIVSGTA----VLSANSANTNGSGKATVTLKSDKP 629 Query: 1708 GGVTVASGTQMLTG----------DNTYTGGTTIAAGGTLQLGNGGTSGSVAGNVVDNGA 1757 G V V++ T +T D T T I A T + NG + + V+ Sbjct: 630 GQVVVSAKTAEMTSALNANAVIFVDQTKASITEIKADKTTAVANGQDAITYTVKVMKGDK 689 Query: 1758 LIVNQSGNVTIASVLSGTGSLTQAGSGRLTLTGTSTLSGPTTVGAGTLAVNGSLGQSTVT 1817 + NQ T + +G +T TST G + V A V + V Sbjct: 690 PVSNQEVTFTTTLGKLSNSTEKTDTNGYAKVTLTSTTPGKSLVSARVSDVAVDVKAPEVE 749 Query: 1818 VQNGATLTGTG-TIGGLVVQGGATAAATQPGAALNV--GGNVTFQPGSTFQVAATPQQSG 1874 T+ I G V+G Q G GGN + S A+ Sbjct: 750 FFTTLTIDDGNIEIVGTGVKGKLPTVWLQYGQVNLKASGGNGKYTWRSANPAIASVD--- 806 Query: 1875 SLAASGTATLNGGTVQVLANQSGYQPSTTYTILSASSGV 1913 A+SG TL ++ S + TYTI + +S + Sbjct: 807 --ASSGQVTLKEKGTTTISVISSDNQTATYTIATPNSLI 843
>CHLAMIDIAOMP#Chlamydia major outer membrane protein signature. Length = 393 Score = 26.1 bits (57), Expect = 0.014 Identities = 11/35 (31%), Positives = 19/35 (54%) Query: 42 FTDAVHPVSLRKVKKRRRKTCRIVISDSLSGSKKY 76 D + VSL+ K + RK+C I + ++ + KY Sbjct: 337 LGDTMQIVSLQLNKMKSRKSCGIAVGTTIVDADKY 371
>OMPADOMAIN#OMPA domain signature. Length = 346 Score = 30.7 bits (69), Expect = 0.004 Identities = 9/24 (37%), Positives = 17/24 (70%) Query: 103 GLNEATAMRDYLVARGVPADRIAV 126 A ++ DYL+++G+PAD+I+ Sbjct: 274 SERRAQSVVDYLISKGIPADKISA 297
>SHAPEPROTEIN#Bacterial cell shape determinant MreB/Mbl protein signature. Length = 347 Score = 354 bits (910), Expect = e-124 Identities = 166/340 (48%), Positives = 226/340 (66%), Gaps = 2/340 (0%) Query: 1 MSTPLFGKLFAQPVAIDPGTASTRIYTHERGVVLNQPSVVCFRKGGASDARPTLEAVGEL 60 M G +F+ ++ID GTA+T IY +G+VLN+PSVV R+ A + AVG Sbjct: 1 MLKKFRG-MFSNDLSIDLGTANTLIYVKGQGIVLNEPSVVAIRQDRAGSPKSVA-AVGHD 58 Query: 61 AKALLGREPGHLEAVRPMRHGVIADAHAAEQMIRSFIDMSRTRSRFGRRVEVTLCVPSDA 120 AK +LGR PG++ A+RPM+ GVIAD E+M++ FI + S V +CVP A Sbjct: 59 AKQMLGRTPGNIAAIRPMKDGVIADFFVTEKMLQHFIKQVHSNSFMRPSPRVLVCVPVGA 118 Query: 121 TAVERRAIREAAFAAGVSEVELIEESLAAGLGAGLPVTEPVGSMVIDIGGGTTEVAVIAL 180 T VERRAIRE+A AG EV LIEE +AA +GAGLPV+E GSMV+DIGGGTTEVAVI+L Sbjct: 119 TQVERRAIRESAQGAGAREVFLIEEPMAAAIGAGLPVSEATGSMVVDIGGGTTEVAVISL 178 Query: 181 GGIVYREAIRVGGSQFDAAIVNHVRNLYGVLLGEQTAEHVKKAIGSATSAVPRTSTRAVG 240 G+VY ++R+GG +FD AI+N+VR YG L+GE TAE +K IGSA G Sbjct: 179 NGVVYSSSVRIGGDRFDEAIINYVRRNYGSLIGEATAERIKHEIGSAYPGDEVREIEVRG 238 Query: 241 RSIGDGLPRSVELSNHDVADALAAPLKQVIGAVKSVLENAPAELVTDIANRGVVLTGGGA 300 R++ +G+PR L+++++ +AL PL ++ AV LE P EL +DI+ RG+VLTGGGA Sbjct: 239 RNLAEGVPRGFTLNSNEILEALQEPLTGIVSAVMVALEQCPPELASDISERGMVLTGGGA 298 Query: 301 LLADLERLLYDETGLVARIADEPATCAVRGAGEAMGRLAM 340 LL +L+RLL +ETG+ +A++P TC RG G+A+ + M Sbjct: 299 LLRNLDRLLMEETGIPVVVAEDPLTCVARGGGKALEMIDM 338
>PF06580#Sensor histidine kinase Length = 349 Score = 31.8 bits (72), Expect = 0.004 Identities = 34/184 (18%), Positives = 70/184 (38%), Gaps = 35/184 (19%) Query: 201 DSIAQDVTELEELIDMSLTYARLEYSSLQSNLEMTAPVAWFEHQVNDAQLLYPDRAIESR 260 + +T L EL+ SL Y+ SL L + + + A + + DR ++ Sbjct: 191 TKAREMLTSLSELMRYSLRYSNARQVSLADELTVV------DSYLQLASIQFEDR-LQFE 243 Query: 261 IEIGADLRVKMDRRLMSYAMRNLLRNASKYA------KSRIVVGISLVHGNVGIFVEDDG 314 +I + D ++ ++ L+ N K+ +I++ + +G V + VE+ G Sbjct: 244 NQINPAIM---DVQVPPMLVQTLVENGIKHGIAQLPQGGKILLKGTKDNGTVTLEVENTG 300 Query: 315 PGVPESERERIFDAFVRLDRRTGGYGLGLSITR---QVLHAHNGRIAVVDPVELGGARFE 371 ++ +E G GL R Q+L+ +I + + + G Sbjct: 301 SLALKNTKE--------------STGTGLQNVRERLQMLYGTEAQIKLSE--KQGKVNAM 344 Query: 372 ISWP 375 + P Sbjct: 345 VLIP 348
>HTHFIS#FIS bacterial regulatory protein HTH signature. Length = 484 Score = 69.9 bits (171), Expect = 6e-16 Identities = 29/124 (23%), Positives = 59/124 (47%), Gaps = 1/124 (0%) Query: 10 RILLVEDDTRLSTLIAGYLRKNDYEVDTVLHGDAAVPAILSIRPDLVILDVNLPGKDGFE 69 IL+ +DD + T++ L + Y+V + I + DLV+ DV +P ++ F+ Sbjct: 5 TILVADDDAAIRTVLNQALSRAGYDVRITSNAATLWRWIAAGDGDLVVTDVVMPDENAFD 64 Query: 70 ICREARKQYDGV-IIMVTARDEPFDELLGLEFGADDYVHKPVEPRILLARIKAQLRRAPA 128 + +K + +++++A++ + E GA DY+ KP + L+ I L Sbjct: 65 LLPRIKKARPDLPVLVMSAQNTFMTAIKASEKGAYDYLPKPFDLTELIGIIGRALAEPKR 124 Query: 129 RAAE 132 R ++ Sbjct: 125 RPSK 128
>DHBDHDRGNASE#2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase signature. Length = 261 Score = 63.1 bits (153), Expect = 1e-13 Identities = 51/207 (24%), Positives = 88/207 (42%), Gaps = 19/207 (9%) Query: 9 GRRIVITGANSGTGKEATRRLVAAGADVIMAVRSESKGDAARRDIRKEFPGTSIEVRTLD 68 G+ ITGA G G+ R L + GA + + K + ++ E E D Sbjct: 8 GKIAFITGAAQGIGEAVARTLASQGAHIAAVDYNPEKLEKVVSSLKAE--ARHAEAFPAD 65 Query: 69 LSSLASVRNFGRQLLEEGRPLDVLVNNAGIMMP-PTRVLSSDGFELQLATNFLGHFALTN 127 + A++ ++ E P+D+LVN AG++ P LS + +E + N G F + Sbjct: 66 VRDSAAIDEITARIEREMGPIDILVNVAGVLRPGLIHSLSDEEWEATFSVNSTGVFNASR 125 Query: 128 LLLPLLLEAKSPRVATMTSSAAMGATINFDDLQGERSYKPMTAYAQSKLACLLLANRLA- 186 + +++ +S + T+ S+ A + M AYA SK A ++ L Sbjct: 126 SVSKYMMDRRSGSIVTVGSNPAGVPRTS------------MAAYASSKAAAVMFTKCLGL 173 Query: 187 EIARERGWPLLSTSAHPGHTRTNLQTS 213 E+A + + PG T T++Q S Sbjct: 174 ELA---EYNIRCNIVSPGSTETDMQWS 197
>YERSSTKINASE#Yersinia serine/threonine protein kinase signature. Length = 732 Score = 34.7 bits (79), Expect = 7e-04 Identities = 32/105 (30%), Positives = 43/105 (40%), Gaps = 16/105 (15%) Query: 262 AGGHPNLIPVIGKLRGHPDGT---HGLVMELVD-----PALTNLAGPPSFASCTRDVYAA 313 AG HPNL V G + P G L+M+ VD L LA + Y Sbjct: 187 AGKHPNLANVHG-MAVVPYGNRKEEALLMDEVDGWRCSDTLRTLADSWKQGKINSEAYWG 245 Query: 314 DARFEPAQALRIAHGIASVAGHLHARGIMHGDLYAHNILHDGAGG 358 +F IAH + V HL G++H D+ N++ D A G Sbjct: 246 TIKF-------IAHRLLDVTNHLAKAGVVHNDIKPGNVVFDRASG 283
>TCRTETB#Tetracycline resistance protein TetB signature. Length = 458 Score = 54.9 bits (132), Expect = 3e-10 Identities = 73/363 (20%), Positives = 128/363 (35%), Gaps = 50/363 (13%) Query: 85 LPAFAHEFNVGAASSSLSLSLSTGMLAVSILCAGALSERVGRRGLMFASMTLAALFNLLA 144 LP A++FN AS++ + ++ G LS+++G + L+ + + +++ Sbjct: 37 LPDIANDFNKPPASTNWVNTAFMLTFSIGTAVYGKLSDQLGIKRLLLFGIIINCFGSVIG 96 Query: 145 AWSPNWHLLLVW-RALEGFALGGVPAVAMAYLAEEIAADGLGFSMGLYVGGTAFGGMIGR 203 ++ LL+ R ++G PA+ M +A I + G + GL A G +G Sbjct: 97 FVGHSFFSLLIMARFIQGAGAAAFPALVMVVVARYIPKENRGKAFGLIGSIVAMGEGVGP 156 Query: 204 IGMSALEEHFSWRTAML--SIGVVDLLAAIAF----------------VMLLPASRRFVK 245 + + W +L I ++ + + +++ F+ Sbjct: 157 AIGGMIAHYIHWSYLLLIPMITIITVPFLMKLLKKEVRIKGHFDIKGIILMSVGIVFFML 216 Query: 246 RTDLTLRHHLRLW-------HAQLRHARLPFV---------FAIGFLVMG-AFVTIYNYA 288 T L + +R PFV F IG L G F T+ A Sbjct: 217 FTTSYSISFLIVSVLSFLIFVKHIRKVTDPFVDPGLGKNIPFMIGVLCGGIIFGTV---A 273 Query: 289 GFRLMAA-----PFNLSPTACG--LIFGAYLFGMVSSSSAGALADRLGRAPVLVSGIVVF 341 GF M LS G +IF + ++ G L DR G VL G+ Sbjct: 274 GFVSMVPYMMKDVHQLSTAEIGSVIIFPGTMSVIIFGYIGGILVDRRGPLYVLNIGVTFL 333 Query: 342 AAG---LALTLSHSLVAIVVGIVLVTIGFFVAHSVASGWV-GALAGAAKGHAASLYLLAY 397 + + L + + + IV V G +V S V +L G SL Sbjct: 334 SVSFLTASFLLETTSWFMTIIIVFVLGGLSFTKTVISTIVSSSLKQQEAGAGMSLLNFTS 393 Query: 398 YVG 400 ++ Sbjct: 394 FLS 396
>ISCHRISMTASE#Isochorismatase signature. Length = 312 Score = 55.8 bits (134), Expect = 5e-10 Identities = 30/63 (47%), Positives = 38/63 (60%), Gaps = 3/63 (4%) Query: 31 IAELLDESVDEIASLDDDEDLLSCGLDSIRLMYLQTRVNRLGHALTFDALARTPTLGAWT 90 IAELL E+ ++I D EDLL GLDS+R+M L + R G +TF LA PT+ W Sbjct: 239 IAELLQETPEDI---TDQEDLLDRGLDSVRIMTLVEQWRREGAEVTFVELAERPTIEEWQ 295 Query: 91 ALL 93 LL Sbjct: 296 KLL 298
>IGASERPTASE#IgA-specific serine endopeptidase (S6) signature. Length = 1541 Score = 36.2 bits (83), Expect = 0.001 Identities = 17/145 (11%), Positives = 37/145 (25%), Gaps = 4/145 (2%) Query: 44 QRKQQNQRAAADAFAISATPPPTPLPLAERV---ARLEATVDTLTRELDALRAQLAGAKA 100 + +N + + + V A+ +T T E+ ++ + Sbjct: 1038 ETVAENSKQESKTVEKNEQDATETTAQNREVAKEAKSNVKANTQTNEVAQSGSETKETQT 1097 Query: 101 GAATS-GDIAQTASAGASAVPLPAHVPTTPTPQPVAARADTPASISTPAPAAAPATAART 159 + + A T P +++T + PA P + Sbjct: 1098 TETKETATVEKEEKAKVETEKTQEVPKVTSQVSPKQEQSETVQPQAEPARENDPTVNIKE 1157 Query: 160 ATASAHANTTASAPATSTRPAPPAP 184 + + PA T P Sbjct: 1158 PQSQTNTTADTEQPAKETSSNVEQP 1182
>SACTRNSFRASE#Streptothricin acetyltransferase signature. Length = 173 Score = 50.3 bits (120), Expect = 7e-10 Identities = 28/120 (23%), Positives = 46/120 (38%), Gaps = 18/120 (15%) Query: 61 DQDEDVTRRRAEAGECYVAVCGGRVVGTATLYATDPSSACSLYRREGVASVRQVAVDPAC 120 D D DV+ E ++ +G + S + Y A + +AV Sbjct: 52 DDDMDVSYVEEEGKAAFLYYLENNCIGRIKI-----RSNWNGY-----ALIEDIAVAKDY 101 Query: 121 QSRGIGALLMSFAEQWAALRGYALLALDTPH---PAAHLLAFYGAQGFEV--VDVMRFAG 175 + +G+G L+ A +WA + L L+T A H FY F + VD M ++ Sbjct: 102 RKKGVGTALLHKAIEWAKENHFCGLMLETQDINISACH---FYAKHHFIIGAVDTMLYSN 158
>GPOSANCHOR#Gram-positive coccus surface protein anchor signature. Length = 539 Score = 32.7 bits (74), Expect = 0.003 Identities = 16/38 (42%), Positives = 26/38 (68%) Query: 200 IHDAPRVAMREDEDVSREIQQALEADGIKLELQSRIAN 237 + +A R ++R D D SRE ++ LEA+ KLE Q++I+ Sbjct: 306 VLNANRQSLRRDLDASREAKKQLEAEHQKLEEQNKISE 343
>TCRTETB#Tetracycline resistance protein TetB signature. Length = 458 Score = 38.3 bits (89), Expect = 5e-05 Identities = 28/156 (17%), Positives = 62/156 (39%), Gaps = 1/156 (0%) Query: 252 IFSSKIFWIFGIIYFLDVFGIYGYTLWAPTIIKSLGVERNSLIGLLAALPNAVAVIVM-I 310 + + F I + + + G+ P ++K + + IG + P ++VI+ Sbjct: 252 LGKNIPFMIGVLCGGIIFGTVAGFVSMVPYMMKDVHQLSTAEIGSVIIFPGTMSVIIFGY 311 Query: 311 IAGRKADSRRERRLLVAALFLMAAAGLTLALVWHGTLWLSIAALCIANAGLLSIPPIFWG 370 I G D R +L + ++ + LT + + T W + GL + Sbjct: 312 IGGILVDRRGPLYVLNIGVTFLSVSFLTASFLLETTSWFMTIIIVFVLGGLSFTKTVIST 371 Query: 371 MPTAVLSPRNAASGIAWISAIGNIGGFFGPYVVGLL 406 + ++ L + A +G++ ++ + G +VG L Sbjct: 372 IVSSSLKQQEAGAGMSLLNFTSFLSEGTGIAIVGGL 407 Score = 35.2 bits (81), Expect = 5e-04 Identities = 32/161 (19%), Positives = 60/161 (37%), Gaps = 2/161 (1%) Query: 246 SINQNNIFSSKIFWIFGIIYFLDVFGIYGYTLWAPTIIKSLGVERNSLIGLLAALPNAVA 305 S +Q+N+ ++I I+ F V + P I S + A + Sbjct: 4 SYSQSNLRHNQILIWLCILSFFSVLNEMVLNVSLPDIANDFNKPPASTNWVNTAFMLTFS 63 Query: 306 VIVMIIAGRKADSRRERRLLVAALFLMAAAGLTLALVWHGTLWLSIAALCIANAGLLSIP 365 + + G+ +D +RLL+ + + + + V H L I A I AG + P Sbjct: 64 IGTAVY-GKLSDQLGIKRLLLFGIIINCFGSV-IGFVGHSFFSLLIMARFIQGAGAAAFP 121 Query: 366 PIFWGMPTAVLSPRNAASGIAWISAIGNIGGFFGPYVVGLL 406 + + + N I +I +G GP + G++ Sbjct: 122 ALVMVVVARYIPKENRGKAFGLIGSIVAMGEGVGPAIGGMI 162
>HTHFIS#FIS bacterial regulatory protein HTH signature. Length = 484 Score = 99.5 bits (248), Expect = 1e-26 Identities = 32/143 (22%), Positives = 62/143 (43%) Query: 16 VVDDDDSMRSALGMLLRSVGLRVELFSSAQEFLAFDKPDVSSCLILDVRLKGQSGLVLQE 75 V DDD ++R+ L L G V + S+A + ++ DV + ++ L Sbjct: 8 VADDDAAIRTVLNQALSRAGYDVRITSNAATLWRWIAAGDGDLVVTDVVMPDENAFDLLP 67 Query: 76 QIVAGDMGLPIIFITAHGDVAMSVKAMKNGALDFLSKPFRDQEMLDAVEGALLKHEARRR 135 +I LP++ ++A ++KA + GA D+L KPF E++ + AL + + R Sbjct: 68 RIKKARPDLPVLVMSAQNTFMTAIKASEKGAYDYLPKPFDLTELIGIIGRALAEPKRRPS 127 Query: 136 TDGRVAEVRRRYESLTPREREVM 158 ++ + +E+ Sbjct: 128 KLEDDSQDGMPLVGRSAAMQEIY 150
>HTHFIS#FIS bacterial regulatory protein HTH signature. Length = 484 Score = 62.5 bits (152), Expect = 4e-15 Identities = 17/86 (19%), Positives = 36/86 (41%) Query: 1 MRSLGWEVRTYESGEEFLSAERIADVACIISDVQMPGISGLEMYEMLLERGVAPPVIFIT 60 + G++VR + D +++DV MP + ++ + + PV+ ++ Sbjct: 23 LSRAGYDVRITSNAATLWRWIAAGDGDLVVTDVVMPDENAFDLLPRIKKARPDLPVLVMS 82 Query: 61 SFPSEATHRQAMKLGAICVFSKPVDP 86 + + T +A + GA KP D Sbjct: 83 AQNTFMTAIKASEKGAYDYLPKPFDL 108
>TCRTETB#Tetracycline resistance protein TetB signature. Length = 458 Score = 58.0 bits (140), Expect = 3e-11 Identities = 36/151 (23%), Positives = 64/151 (42%), Gaps = 5/151 (3%) Query: 37 LPVMAKDFGLPVPTVAVLVIVFTLVLALSSPISTVATGRMARKWVLLAAMSLFAIGNVTA 96 LP +A DF P + + F L ++ + + + ++ K +LL + + G+V Sbjct: 37 LPDIANDFNKPPASTNWVNTAFMLTFSIGTAVYGKLSDQLGIKRLLLFGIIINCFGSVIG 96 Query: 97 AVSASFA-LLIGARVLMAIAAGLYVPAANGLAGVIVPPSMRGRALAIVSAGQTLAIALGL 155 V SF LLI AR + A + + +P RG+A ++ + + +G Sbjct: 97 FVGHSFFSLLIMARFIQGAGAAAFPALVMVVVARYIPKENRGKAFGLIGSIVAMGEGVGP 156 Query: 156 PLGGMIGHAFGWRATFLLVGAMSVIAIAGIF 186 +GGMI H W L+ +I I + Sbjct: 157 AIGGMIAHYIHWSYLLLI----PMITIITVP 183
>DHBDHDRGNASE#2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase signature. Length = 261 Score = 72.8 bits (178), Expect = 2e-17 Identities = 43/190 (22%), Positives = 83/190 (43%), Gaps = 5/190 (2%) Query: 3 MTGNTIFITGGTSGIGRALAEQFHALGNKVIIAGRRKALLDEVTTANPGM----EGVALD 58 + G FITG GIG A+A + G + L++V ++ E D Sbjct: 6 IEGKIAFITGAAQGIGEAVARTLASQGAHIAAVDYNPEKLEKVVSSLKAEARHAEAFPAD 65 Query: 59 ISDAADIDRVAAQLIRDYPSLNVLINNAGIMPFDDPSGRIDDSVSRQILDTNLLGPIRLT 118 + D+A ID + A++ R+ +++L+N AG++ + D N G + Sbjct: 66 VRDSAAIDEITARIEREMGPIDILVNVAGVLRPG-LIHSLSDEEWEATFSVNSTGVFNAS 124 Query: 119 SALIEHLKAQPRATIIHNTSVLAYVPIATNAVYSASKAALHSYALSQRFMLKGTSVSVQE 178 ++ +++ + +I+ S A VP + A Y++SKAA + L ++ Sbjct: 125 RSVSKYMMDRRSGSIVTVGSNPAGVPRTSMAAYASSKAAAVMFTKCLGLELAEYNIRCNI 184 Query: 179 IAPPWVDTDL 188 ++P +TD+ Sbjct: 185 VSPGSTETDM 194
>HTHFIS#FIS bacterial regulatory protein HTH signature. Length = 484 Score = 30.6 bits (69), Expect = 0.013 Identities = 19/115 (16%), Positives = 36/115 (31%), Gaps = 11/115 (9%) Query: 119 SRRPRARRVQIFSPDALEQANAALDGADASQQQCARPLLEKAGSNDGCRKLPDIQKALKR 178 RP + + + + A A + A L + G R L + ++ + Sbjct: 71 KARPDLPVLVMSAQNTFMTAIKASE-KGAYDYLPKPFDLTELIGIIG-RALAEPKRRPSK 128 Query: 179 LDVARGSFANL---SEPIGKLMVDLVLASAVRSREFRVRPILLMGEPGVGKTHFA 230 L+ L S + ++ L +++ GE G GK A Sbjct: 129 LEDDSQDGMPLVGRSAAMQEIYRVLARLMQTDL------TLMITGESGTGKELVA 177
>OMADHESIN#Yersinia outer membrane adhesin signature. Length = 455 Score = 35.3 bits (80), Expect = 0.003 Identities = 44/129 (34%), Positives = 65/129 (50%), Gaps = 2/129 (1%) Query: 244 GATGRNVAIGSSGTTANGATAAGGAVAIGRGQVATGDGAVAIGDPNSATGTGALAIGAND 303 G I S A A G AVA+G G +ATG +VAIG + A G A+ GA Sbjct: 62 GLNASAKGIHSIAIGATAEAAKGAAVAVGAGSIATGVNSVAIGPLSKALGDSAVTYGAAS 121 Query: 304 TSNGSGAIALGNSNSASGTGSVALGNSSTATNSAVAIGSSASATGTNG-AIAIGNAATAN 362 T+ G +A+G S S TG NS ++VAIG S+ +G +IAIG+ + + Sbjct: 122 TAQKDG-VAIGARASTSDTGVAVGFNSKADAKNSVAIGHSSHVAANHGYSIAIGDRSKTD 180 Query: 363 GTGAIALGN 371 ++++G+ Sbjct: 181 RENSVSIGH 189 Score = 35.3 bits (80), Expect = 0.003 Identities = 64/294 (21%), Positives = 109/294 (37%) Query: 2265 AAGVNASAAGASSVAVGDGSNAQTAGAVAIGQNASATGGKAVSIGSGNTASGDGAVAIGD 2324 A G+NASA G S+A+G + A AVA+G + ATG +V+IG + A GD AV G Sbjct: 60 AGGLNASAKGIHSIAIGATAEAAKGAAVAVGAGSIATGVNSVAIGPLSKALGDSAVTYGA 119 Query: 2325 PNVATGTGAVAMGANNTATGDGAVSLGNQNTATGASALALGSSNQATADNTIALGSQATA 2384 + A G +T+ AV ++ A + A+ S A +IA+G ++ Sbjct: 120 ASTAQKDGVAIGARASTSDTGVAVGFNSKADAKNSVAIGHSSHVAANHGYSIAIGDRSKT 179 Query: 2385 GATGAQAYGSAAKATAADALAFGTNAQANVANSIALGANSVTAAAVGTSSATIGGVTYPF 2444 + + G + LA GT V + T SA + + Sbjct: 180 DRENSVSIGHESLNRQLTHLAAGTKDTDAVNVAQLKKEIEKTQENTNKRSAELLANANAY 239 Query: 2445 AGGSPVGVVSVGAPGQERQITNVAAGRISATSTDAINGSQLNATNNAINTLSTSTASNVA 2504 A V+ + + + + + + ++ +T + Sbjct: 240 ADNKSSSVLGIANNYTDSKSAETLENARKEAFAQSKDVLNMAKAHSNSVARTTLETAEEH 299 Query: 2505 SLSTGINSLSTGLSTTNSNVASLSTSTSTAINSLSTGLSTTNNNVNSLSTSTST 2558 + S +L T N A S + +S S+ T N+ ++ S ST Sbjct: 300 ANSVARTTLETAEEHANKKSAEALASANVYADSKSSHTLKTANSYTDVTVSNST 353
>DHBDHDRGNASE#2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase signature. Length = 261 Score = 52.0 bits (124), Expect = 2e-10 Identities = 50/198 (25%), Positives = 78/198 (39%), Gaps = 19/198 (9%) Query: 24 ADVTRPETIVSA----LADIAHVDHLVLLAGTFVAGKVLDADVDYLRRAFDERVWAAVHT 79 ADV I ++ +D LV +AG G + + F + Sbjct: 64 ADVRDSAAIDEITARIEREMGPIDILVNVAGVLRPGLIHSLSDEEWEATFSVNSTGVFNA 123 Query: 80 LRALGDRLAA--DASVTFISGVLADRPNAYGTAILASASAAMEALARGLVLELAPR--RV 135 R++ + S+ + A P A AS+ AA + L LELA R Sbjct: 124 SRSVSKYMMDRRSGSIVTVGSNPAGVPRT-SMAAYASSKAAAVMFTKCLGLELAEYNIRC 182 Query: 136 NTVSPGTTDTPLLARTLGEGRDA-------YVNALKDKLPLHRLGTAEEVGAAVVFLMSN 188 N VSPG+T+T + +L + + K +PL +L ++ AV+FL+S Sbjct: 183 NIVSPGSTETD-MQWSLWADENGAEQVIKGSLETFKTGIPLKKLAKPSDIADAVLFLVSG 241 Query: 189 --GSMNGETIHVDGGARL 204 G + + VDGGA L Sbjct: 242 QAGHITMHNLCVDGGATL 259
>TCRTETB#Tetracycline resistance protein TetB signature. Length = 458 Score = 46.8 bits (111), Expect = 8e-08 Identities = 30/155 (19%), Positives = 61/155 (39%), Gaps = 3/155 (1%) Query: 40 LTPIAHDLNATEGIAGQAISISGFFAVLASLFVAPLAGRFD-RRHVLMSMTVLMLISIVL 98 L IA+D N + + + L+ + +R +L + + S++ Sbjct: 37 LPDIANDFNKPPASTNWVNTAFMLTFSIGTAVYGKLSDQLGIKRLLLFGIIINCFGSVIG 96 Query: 99 IAVSPNFAVLMIARAFLGLAVGGFWSLSTATVIQLVPAQRVPKALGTIYMGNAIATAFAA 158 F++L++AR G F +L V + +P + KA G I A+ Sbjct: 97 FVGHSFFSLLIMARFIQGAGAAAFPALVMVVVARYIPKENRGKAFGLIGSIVAMGEGVGP 156 Query: 159 PIGAYVGGHLGWRFVFAALVPLVLVNLVWQAVSLP 193 IG + ++ W ++ L+P++ + V + L Sbjct: 157 AIGGMIAHYIHWSYLL--LIPMITIITVPFLMKLL 189
>ECOLNEIPORIN#E.coli/Neisseria porin superfamily signature. Length = 331 Score = 96.0 bits (239), Expect = 2e-24 Identities = 86/390 (22%), Positives = 134/390 (34%), Gaps = 64/390 (16%) Query: 1 MNKKLLTIAALAATAGTAHAQSSVTLYGVIDAGISYVNHSKTANGGTGKLFKYDDGVAQG 60 M K L+ AL A A + VTLYG I AG+ + V G Sbjct: 1 MKKSLI---ALTLAALPVAAMADVTLYGTIKAGVETSRSVAHNGAQAASVETGTGIVDLG 57 Query: 61 SRWGLRGTEDLGGGLKAIFVLENGFNSGNGTIGQGGAIFGRQAYVGLSQSQYGTVTFGRQ 120 S+ G +G EDLG GLKAI+ +E G RQ+++GL +G + GR Sbjct: 58 SKIGFKGQEDLGNGLKAIWQVE----QKASIAGTDSGWGNRQSFIGLK-GGFGKLRVGRL 112 Query: 121 YSFSTDILGSNYSTGGNTVAGNYAYHVNDIDQLTSSRINNAVKFQSANYSGFTFGALYGF 180 S D N + G + +L S V++ S ++G + Y Sbjct: 113 NSVLKDTGDINPWDSKSDYLGVNKIAEPE-ARLIS------VRYDSPEFAGLSGSVQYAL 165 Query: 181 SNSTDFAGAPATTTGTTTTAGSSRAYSFGLNYANGPVSVGAAYTDIRYPSQSTPGFSTTI 240 +++ +S +Y G NY NG V R+ Sbjct: 166 NDNAGR--------------HNSESYHAGFNYKNGGFFVQYGGAYKRHHQVQ-------- 203 Query: 241 ANLSTGNVRDLRTYGVGGRYVWGPATAWLLWTRTQFSTVSGAGGTFYNAYEAGAKYAF-- 298 N+ + + + Y A + + Q + + + + E A A+ Sbjct: 204 ---ENVNIEKYQIHRLVSGYDNDALYA-SVAVQQQDAKLVEENYSHNSQTEVAATLAYRF 259 Query: 299 ---TPALSGGLGYTYTNATQNGNSWHWNQVNGIADYALSKRTDVYGLVVYQQASGKGVQA 355 TP +S G+ + N N+ ++QV A+Y SKRT + Q Sbjct: 260 GNVTPRVSYAHGFKGSFDATNYNN-DYDQVVVGAEYDFSKRTSALVSAGWLQ-------- 310 Query: 356 QIGSSTSYFNTSGTGSKNQIAARIGIRHKF 385 G A +G+RHKF Sbjct: 311 ---------EGKGESKFVSTAGGVGLRHKF 331
>FERRIBNDNGPP#Ferrichrome-binding periplasmic protein signature. Length = 296 Score = 60.7 bits (147), Expect = 8e-13 Identities = 72/284 (25%), Positives = 115/284 (40%), Gaps = 25/284 (8%) Query: 10 RRSLLGGAAASALAGALPGGVLAQVAAAAPKRVIVIGGALAETAFAL-----GGAETPRY 64 RR LL A S L + A AA P R++ + E AL G A+T Y Sbjct: 9 RRRLLTAMALSPLLWQMNT---AHAAAIDPNRIVALEWLPVELLLALGIVPYGVADTINY 65 Query: 65 RLVGADTTCTYPDAAKRLPKVGYQRALSAEGLLSLRPDLVLASAEAGP-PTAIAQVKGAG 123 RL ++ P + VG + + E L ++P ++ SA GP P +A++ G Sbjct: 66 RLWVSE-----PPLPDSVIDVGLRTEPNLELLTEMKPSFMVWSAGYGPSPEMLARI-APG 119 Query: 124 VTVTTFDERHDVESVRAKITGVAQALDVRDAGTVLLQRFDRDWQAARDAVAARVPGGAQP 183 D + + R +T +A L+++ A L +++ ++ + R Sbjct: 120 RGFNFSDGKQPLAMARKSLTEMADLLNLQSAAETHLAQYEDFIRSMK----PRFVKRGAR 175 Query: 184 PRVLFVLNHTGTQALVAGQRTAADAMIRYAGARNAMQGFDHYKPLTT---EALAAAAPDV 240 P +L L LV G + ++ G NA QG ++ T + LAA Sbjct: 176 PLLLTTLIDP-RHMLVFGPNSLFQEILDEYGIPNAWQGETNFWGSTAVSIDRLAAYKDVD 234 Query: 241 VLISDEGLAAVGGHAALLATPGFGATPAGRARRVVSLDALFLLG 284 VL D + AL+ATP + A P RA R + A++ G Sbjct: 235 VLCFDHDNSKD--MDALMATPLWQAMPFVRAGRFQRVPAVWFYG 276
>DHBDHDRGNASE#2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase signature. Length = 261 Score = 65.1 bits (158), Expect = 9e-15 Identities = 52/208 (25%), Positives = 88/208 (42%), Gaps = 17/208 (8%) Query: 3 IEGAVVFITGANRGLGLEFAKQALERGARKVYAGARDP-------ASVTLPGVVP--VKL 53 IEG + FITGA +G+G A+ +GA + A +P +S+ Sbjct: 6 IEGKIAFITGAAQGIGEAVARTLASQGA-HIAAVDYNPEKLEKVVSSLKAEARHAEAFPA 64 Query: 54 DVTDPAAVAA-----AADAARDVTLLINNAGIARLGSLTDEGAVDALRAHLETNVFGMLA 108 DV D AA+ + + +L+N AG+ R G L + + A N G+ Sbjct: 65 DVRDSAAIDEITARIEREMGP-IDILVNVAGVLRPG-LIHSLSDEEWEATFSVNSTGVFN 122 Query: 109 MSRAFAGTLAAHGGGAILNILSVASWVNRPILSGYGVSKSAAWALTNGLRHSLREQHTQV 168 SR+ + + G+I+ + S + V R ++ Y SK+AA T L L E + + Sbjct: 123 ASRSVSKYMMDRRSGSIVTVGSNPAGVPRTSMAAYASSKAAAVMFTKCLGLELAEYNIRC 182 Query: 169 VGLHAGFIDTDLTAGLDVPKATPADVVR 196 + G +TD+ L + V++ Sbjct: 183 NIVSPGSTETDMQWSLWADENGAEQVIK 210
>HTHTETR#TetR bacterial regulatory protein HTH signature. Length = 215 Score = 61.6 bits (149), Expect = 5e-14 Identities = 42/205 (20%), Positives = 67/205 (32%), Gaps = 15/205 (7%) Query: 1 MGVSRQQAAENRHAIVAAAERLFRLRGVDAVGLTELMKEAGFTQGGFYNHFKSKDALVAE 60 ++Q+A E R I+ A RLF +GV + L E+ K AG T+G Y HFK K L +E Sbjct: 2 ARKTKQEAQETRQHILDVALRLFSQQGVSSTSLGEIAKAAGVTRGAIYWHFKDKSDLFSE 61 Query: 61 VMDKAMQ------DRADSPNAGSVAKQVTAYLSGAHRDNVEGG---------CPLSGFAG 105 + + + + G + L V F G Sbjct: 62 IWELSESNIGELELEYQAKFPGDPLSVLREILIHVLESTVTEERRRLLMEIIFHKCEFVG 121 Query: 106 DAPRLIDAARACYTRGVAAYLERLERMVATEGSAAADARDDAIAVLSQMVGALVLSRAVA 165 + + A R + L+ + + A A ++ + L+ + A Sbjct: 122 EMAVVQQAQRNLCLESYDRIEQTLKHCIEAKMLPADLMTRRAAIIMRGYISGLMENWLFA 181 Query: 166 GTDPALADEILDAARRTLVGQPDDP 190 L E D L P Sbjct: 182 PQSFDLKKEARDYVAILLEMYLLCP 206
>AUTOINDCRSYN#Autoinducer synthesis protein signature. Length = 216 Score = 27.1 bits (60), Expect = 0.030 Identities = 7/41 (17%), Positives = 18/41 (43%), Gaps = 2/41 (4%) Query: 109 VAARLMAAAEAAARDAGKTVLVLDTVTGGDAERLYERAGWQ 149 +++ L + ++D G + T+ + +R+GW Sbjct: 119 ISSMLFLSMINYSKDKGYDGIY--TIVSHPMLTILKRSGWG 157
>TCRTETB#Tetracycline resistance protein TetB signature. Length = 458 Score = 29.5 bits (66), Expect = 0.029 Identities = 81/460 (17%), Positives = 160/460 (34%), Gaps = 79/460 (17%) Query: 34 LALAYFFNYLDRTSVGFAALTMNRDLGLTATQFGWGAGIMFAGYCVFEVPSNLALYRFGA 93 L + FF+ L+ + + + D W + + + G Sbjct: 19 LCILSFFSVLNEMVLNVSLPDIANDFNKPPASTNWVNTAFMLTFSIGTAVYGKLSDQLGI 78 Query: 94 RRWLARIMITWGLMAAATALATGPTSFYAI----RLLLGIGEAGFFPGVIFFLAVWFPAS 149 +R L + + + + SF+++ R + G G A F V+ +A + P Sbjct: 79 KRLL---LFGIIINCFGSVIGFVGHSFFSLLIMARFIQGAGAAAFPALVMVVVARYIPKE 135 Query: 150 YRTRVLA-------------------------W-FTVSTPLSSLVGGPLSTWLL----QL 179 R + W + + P+ +++ P LL ++ Sbjct: 136 NRGKAFGLIGSIVAMGEGVGPAIGGMIAHYIHWSYLLLIPMITIITVPFLMKLLKKEVRI 195 Query: 180 DGTFGLAGWKWMFI-----VEGLPACALGFLVLKLLSDSPANAAWLSDDERAALQRAFER 234 G F + G M + + + ++ FL++ +LS + + F Sbjct: 196 KGHFDIKGIILMSVGIVFFMLFTTSYSISFLIVSVLS------FLIFVKHIRKVTDPF-- 247 Query: 235 DGAAAGRKKRFGVALRDVRVYVLALISFGFTMGSY-GIGIWLPQMLK-AHGMSTMQTGWL 292 L +++ ++ G G+ G +P M+K H +ST + G + Sbjct: 248 ----------VDPGLGKNIPFMIGVLCGGIIFGTVAGFVSMVPYMMKDVHQLSTAEIGSV 297 Query: 293 SAVPYFFATIALLWWAKRVDRRGGPVANLAIGLCIGAVA-LGVS-THFLTLGPALVGITL 350 P + I + + R GP+ L IG+ +V+ L S T + I Sbjct: 298 IIFPGTMSVIIFGYIGGILVDRRGPLYVLNIGVTFLSVSFLTASFLLETTSWFMTIIIVF 357 Query: 351 ALIGTIAGRTIFYTLPSRFLSGQAAAGGLALINSIGALGGFAGPYLVGYL---------- 400 L G +T+ T+ S L Q A G++L+N L G +VG L Sbjct: 358 VLGGLSFTKTVISTIVSSSLKQQEAGAGMSLLNFTSFLSEGTGIAIVGGLLSIPLLDQRL 417 Query: 401 -----KDSFGTFTAGMLGLAIVLAITTLLTLSLYAFDRSE 435 S ++ +L + ++ I+ L+TL++Y + + Sbjct: 418 LPMEVDQSTYLYSNLLLLFSGIIVISWLVTLNVYKHSQRD 457
>TCRTETB#Tetracycline resistance protein TetB signature. Length = 458 Score = 45.6 bits (108), Expect = 2e-07 Identities = 57/377 (15%), Positives = 123/377 (32%), Gaps = 54/377 (14%) Query: 57 LAPDLGASARAIGFVPTLTQLGYALGILLLAPLGDRFDRRRVIVTKAAALVVALLLASIA 116 +A D + +V T L +++G + L D+ +R+++ ++ + Sbjct: 40 IANDFNKPPASTNWVNTAFMLTFSIGTAVYGKLSDQLGIKRLLLFGIIINCFGSVIGFVG 99 Query: 117 PS-LGLLLAASF--AIGLAATMAQDVVPAAATLAHDAHRGRIVGTVMTGLLLGILLSRVV 173 S LL+ A F G AA A +V A +RG+ G + + + +G + + Sbjct: 100 HSFFSLLIMARFIQGAGAAAFPALVMV-VVARYIPKENRGKAFGLIGSIVAMGEGVGPAI 158 Query: 174 AGFVAETAGWRAMFALAAASVAVIGAVAARGLPRFEPTTRLPYRA-------------LI 220 G +A W + + + +I L + E + + ++ Sbjct: 159 GGMIAHYIHWSYLLLIPMIT--IITVPFLMKLLKKEVRIKGHFDIKGIILMSVGIVFFML 216 Query: 221 GSLGALWR-----------------------------AHSALRRAALAQGLLAVGFSAFW 251 + + L G++ + F Sbjct: 217 FTTSYSISFLIVSVLSFLIFVKHIRKVTDPFVDPGLGKNIPFMIGVLCGGIIFGTVAGFV 276 Query: 252 STLAVMLHGAPFHLGSAAAGAFGL--AGAAGALAAPVAGRLADHHGPERVTRIGIGIATL 309 S + M+ L +A G+ + + + + G L D GP V IG+ ++ Sbjct: 277 SMVPYMM-KDVHQLSTAEIGSVIIFPGTMSVIIFGYIGGILVDRRGPLYVLNIGVTFLSV 335 Query: 310 SFASMAAAPLMSPHAQLVLLAVATIGFDLGVQATLIAHQSIVYRIDPASRSRLNAVLFVG 369 SF + + + +++ V +G + + + + ++L Sbjct: 336 SFLTASFLLETTSWFMTIII-VFVLGGLSFTK--TVISTIVSSSLKQQEAGAGMSLLNFT 392 Query: 370 MFIGMAAGAAIGSLLLA 386 F+ G AI LL+ Sbjct: 393 SFLSEGTGIAIVGGLLS 409
>PRTACTNFAMLY#Pertactin virulence factor family signature. Length = 910 Score = 31.2 bits (70), Expect = 0.008 Identities = 46/198 (23%), Positives = 66/198 (33%), Gaps = 18/198 (9%) Query: 8 TVTRPGQAMLAAMTAAETGDDVWGDDPTVLRLQAVTAERAGKEAGLFFPSGTQSNLAALM 67 TVT ++A D W DD L + A+ + ++ L G Q Sbjct: 112 TVTVKAGKLVADHATLANVGDTWDDDGIALYVAGEQAQASIADSTLQGAGGVQ------- 164 Query: 68 SHCERGDEYIVGQLAHTYKYEGGGAAVLGSIQPQPIENAPDGTLPLAKIAAAIKPLDNHF 127 ERG V + A GG + G++Q E+ P + L P Sbjct: 165 --IERGANVTVQRSA----IVDGGLHI-GALQSLQPEDLPPSRVVLRDTNVTAVPASGAP 217 Query: 128 ARTRLL-ALENTIGGQVLPEGYVQEAVAFARSRGLATHLDGARVCNAAVASGRPIAELCA 186 A +L A E T+ G + G A A +G HL A + +G + Sbjct: 218 AAVSVLGASELTLDGGHITGG---RAAGVAAMQGAVVHLQRATIRRGDAPAGGAVPGGAV 274 Query: 187 PFDTVSICFSKGLGAPVG 204 P V F G PV Sbjct: 275 PGGAVPGGFGPGGFGPVL 292
>cloacin#Cloacin signature. Length = 551 Score = 27.0 bits (59), Expect = 0.045 Identities = 25/82 (30%), Positives = 34/82 (41%), Gaps = 1/82 (1%) Query: 88 GAAFNGGTGAAVGAGAGLLAGSVVGAGAAQGSAYDVQRR-YDYAYLQCMYATGNRVPVPG 146 G N G + G G G VG GA+ GS + + + ++ G G Sbjct: 6 GRGHNTGAHSTSGNINGGPTGLGVGGGASDGSGWSSENNPWGGGSGSGIHWGGGSGHGNG 65 Query: 147 GMSGGSGGGYGGGGYGTAPRAA 168 G +G SGGG G GG +A A Sbjct: 66 GGNGNSGGGSGTGGNLSAVAAP 87
>HTHFIS#FIS bacterial regulatory protein HTH signature. Length = 484 Score = 29.0 bits (65), Expect = 0.025 Identities = 11/19 (57%), Positives = 14/19 (73%) Query: 56 TVGLVGESGCGKSTLARAL 74 T+ + GESG GK +ARAL Sbjct: 162 TLMITGESGTGKELVARAL 180
>PF06580#Sensor histidine kinase Length = 349 Score = 29.8 bits (67), Expect = 0.007 Identities = 20/95 (21%), Positives = 29/95 (30%), Gaps = 8/95 (8%) Query: 101 WSLFGVSWGLAVFGIVQELTLGRRTRLLSMILYV---LMGWLALVAVRPLIHALP----- 152 W G+ WG+ +L +L SMI + LMG + A R I Sbjct: 13 WYCQGIGWGVYTLTGFGFASLYGSPKLHSMIFNIAISLMGLVLTHAYRSFIKRQGWLKLN 72 Query: 153 PIGTAWLVAGGVIYSAGIYFFINDERIRHGHGIWH 187 V + ++F N R I Sbjct: 73 MGQIILRVLPACVVIGMVWFVANTSIWRLLAFINT 107
>ACRIFLAVINRP#Acriflavin resistance protein family signature. Length = 1034 Score = 30.2 bits (68), Expect = 0.035 Identities = 10/70 (14%), Positives = 25/70 (35%) Query: 165 FGAFLIMVIILAVLALIVVKALTNSPWGTFTVAATIPIALFMGVYTRYIRPGRIGEVSII 224 +V I V+ + + AL S +V +P+ + + + + ++ Sbjct: 869 GNQAPALVAISFVVVFLCLAALYESWSIPVSVMLVVPLGIVGVLLAATLFNQKNDVYFMV 928 Query: 225 GFIGLMAAIA 234 G + + A Sbjct: 929 GLLTTIGLSA 938
>MALTOSEBP#Maltose binding protein signature. Length = 396 Score = 52.0 bits (124), Expect = 2e-09 Identities = 35/100 (35%), Positives = 51/100 (51%), Gaps = 8/100 (8%) Query: 88 APDVVNWHAGERMAYYAKRGLFEDLSGDWSKNGWDAMYASTRSASSYNGKQYAAPTVYYS 147 PD++ W A +R YA+ GL +++ D K D +Y T A YNGK A P + Sbjct: 82 GPDIIFW-AHDRFGGYAQSGLLAEITPD--KAFQDKLYPFTWDAVRYNGKLIAYPIAVEA 138 Query: 148 WGLFYRKDLFRKVGIADEPKTWDQFLDACKKLKAAGITPI 187 L Y KDL + + PKTW++ K+LKA G + + Sbjct: 139 LSLIYNKDL-----LPNPPKTWEEIPALDKELKAKGKSAL 173
>RTXTOXIND#Gram-negative bacterial RTX secretion protein D signature. Length = 478 Score = 42.9 bits (101), Expect = 1e-06 Identities = 20/162 (12%), Positives = 50/162 (30%), Gaps = 14/162 (8%) Query: 92 AGALLGALYEEALKAARDSLDADREQVRADMADAEQRLRDATIRQETLEGALARGEARNE 151 + EE + + + E L + T+ + R E + Sbjct: 172 DEPYFQNVSEEEVLRLTSLIKEQFSTWQNQKYQKELNLDKKRAERLTVLARINRYENLSR 231 Query: 152 QLQARVTELEIQLASQTTHGSASEATLLT---TVARLEKELAAAAGRIDAEQAQNAALRD 208 ++R+ + L + + ++ +L EL ++ + Sbjct: 232 VEKSRLDDFS-SLLHK---QAIAKHAVLEQENKYVEAVNELRVYKSQL-------EQIES 280 Query: 209 RIDALQAELQQRTEHYAQQIKDAVAEAERRVKPMLVELDSLR 250 I + + E Q T+ + +I D + + + + +EL Sbjct: 281 EILSAKEEYQLVTQLFKNEILDKLRQTTDNIGLLTLELAKNE 322
>TCRTETB#Tetracycline resistance protein TetB signature. Length = 458 Score = 57.2 bits (138), Expect = 6e-11 Identities = 74/443 (16%), Positives = 167/443 (37%), Gaps = 43/443 (9%) Query: 24 LVFLMCFVIVLLDGFDTAAIGFIAPSLLGEWNLTKPDLAPVLSAALFGLACGALVSGPLS 83 ++ +C + + + P + ++N V +A + + G V G LS Sbjct: 15 ILIWLCI-LSFFSVLNEMVLNVSLPDIANDFNKPPASTNWVNTAFMLTFSIGTAVYGKLS 73 Query: 84 DRLGRRSLLLGSVFLFGVACLMSAFSNTIGHLTIL-RFITGVGLGAAMPNAVTMMGEFCP 142 D+LG + LLL + + ++ ++ L I+ RFI G G A + ++ + P Sbjct: 74 DQLGIKRLLLFGIIINCFGSVIGFVGHSFFSLLIMARFIQGAGAAAFPALVMVVVARYIP 133 Query: 143 DKRRATVINLMFCGFPLGAAFGGFLAAWMIPHFGWRSVLMLGGVTPLLLGVLLLLK-MPE 201 + R L+ +G G + + + W +L++ +T ++ V L+K + + Sbjct: 134 KENRGKAFGLIGSIVAMGEGVGPAIGGMIAHYIHWSYLLLIPMIT--IITVPFLMKLLKK 191 Query: 202 SVR----------FMVASGQSIDKIRATLSRISRDALNAGSFAL---TEAAPQTGGKGLG 248 VR +++ G + T IS ++ SF + G Sbjct: 192 EVRIKGHFDIKGIILMSVGIVFFMLFTTSYSISFLIVSVLSFLIFVKHIRKVTDPFVDPG 251 Query: 249 VVLSRSYIVGSVMLWLAYFMGLVIFYASINWMPILLKDA-GLTPKSATLISALFP---LG 304 + + +++G + + + ++ +P ++KD L+ + +FP Sbjct: 252 LGKNIPFMIGVLCGGIIF----GTVAGFVSMVPYMMKDVHQLSTAEIGSV-IIFPGTMSV 306 Query: 305 GVGAVLCGVLMDRFNANRVIAVCYALTAVSVYAIG--QAAGNVGLLVLVVFVAGVLMNTA 362 + + G+L+DR V+ + +VS + + +++VFV G L T Sbjct: 307 IIFGYIGGILVDRRGPLYVLNIGVTFLSVSFLTASFLLETTSWFMTIIIVFVLGGLSFTK 366 Query: 363 QSSMPALAAAFYPTE--------------GRGTGVAWMLGVGRFGGIAGSFLVAELTRRH 408 ++++ E GTG+A + G+ + L E+ + Sbjct: 367 TVISTIVSSSLKQQEAGAGMSLLNFTSFLSEGTGIAIVGGLLSIPLLDQRLLPMEVDQST 426 Query: 409 FSFAGVFATIAVAGVLACVALLI 431 + ++ + + V++ + L Sbjct: 427 YLYSNLLLLFSGIIVISWLVTLN 449
>HTHTETR#TetR bacterial regulatory protein HTH signature. Length = 215 Score = 66.2 bits (161), Expect = 3e-15 Identities = 26/109 (23%), Positives = 47/109 (43%), Gaps = 1/109 (0%) Query: 33 EPRGARRKRETRARLLDAAFVLMAQKGMEGVAINEITEAADVGFGSFYNHFESKEAIHAA 92 + + +ETR +LD A L +Q+G+ ++ EI +AA V G+ Y HF+ K + + Sbjct: 2 ARKTKQEAQETRQHILDVALRLFSQQGVSSTSLGEIAKAAGVTRGAIYWHFKDKSDLFSE 61 Query: 93 VLEIVFEEFADTLDRIAGSLT-DPAEIISVSLRHTLLRARSEPVWGQFL 140 + E+ + DP ++ L H L +E + Sbjct: 62 IWELSESNIGELELEYQAKFPGDPLSVLREILIHVLESTVTEERRRLLM 110
>RTXTOXIND#Gram-negative bacterial RTX secretion protein D signature. Length = 478 Score = 136 bits (343), Expect = 5e-38 Identities = 65/413 (15%), Positives = 130/413 (31%), Gaps = 68/413 (16%) Query: 14 RFSRRQLIAAGVVLAVIALAVFGWHWWT-VGRFIESTDDAYVRADVVTVSSRVSGYVTQV 72 SRR + A ++ + +A F V + + + V ++ Sbjct: 52 PVSRRPRLVAYFIMGFLVIA-FILSVLGQVEIVATANGKLTHSGRSKEIKPIENSIVKEI 110 Query: 73 AVDDNQPVKRGDVLVRLDDRDYRAKVDDAQAAVAAADAT--------------------- 111 V + + V++GDVL++L A Q+++ A Sbjct: 111 IVKEGESVRKGDVLLKLTALGAEADTLKTQSSLLQARLEQTRYQILSRSIELNKLPELKL 170 Query: 112 ------------------------LQAEQAAAAMLDAQIGQQRSQIAQADADAAAARAEA 147 Q + + ++R++ A + Sbjct: 171 PDEPYFQNVSEEEVLRLTSLIKEQFSTWQNQKYQKELNLDKKRAERLTVLARINRYENLS 230 Query: 148 ARRDADATRYKQLLAESAASGQRWEQAHADALKARAELTRAGAAV--------RVQTDQQ 199 + + LL + A + + ++A EL + + + + Q Sbjct: 231 RVEKSRLDDFSSLLHKQAIAKHAVLEQENKYVEAVNELRVYKSQLEQIESEILSAKEEYQ 290 Query: 200 TVLQRRREQSTAAIAQARARLAAAQAKLALAQLDLDHTVIRATRDGSVGQRAVRA-GQYV 258 V Q + + + Q + +LA + +VIRA V Q V G V Sbjct: 291 LVTQLFKNEILDKLRQTTDNIGLLTLELAKNEERQQASVIRAPVSVKVQQLKVHTEGGVV 350 Query: 259 EVGMPLLAVVPLSDVYVV-ANFKETQLGAMHDGQPVQIDVDTYSGHTLHGRVIGLAPGSG 317 L+ +VP D V A + +G ++ GQ I V+ + +T +G ++G Sbjct: 351 TTAETLMVIVPEDDTLEVTALVQNKDIGFINVGQNAIIKVEAFP-YTRYGYLVG------ 403 Query: 318 AQFALLPPDNATGNFTKIVQRIPVKIRVDTPPA---GVVLRPGMSVIARVDTR 367 + + D +V + + I + + L GM+V A + T Sbjct: 404 -KVKNINLDAIEDQRLGLVFNVIISIEENCLSTGNKNIPLSSGMAVTAEIKTG 455
>TCRTETB#Tetracycline resistance protein TetB signature. Length = 458 Score = 101 bits (252), Expect = 6e-25 Identities = 79/400 (19%), Positives = 158/400 (39%), Gaps = 17/400 (4%) Query: 30 FMAGMNVHVTNASLPDIRGSLGASFEEGSWITTAYLVAEIVVIPLTGWLVQVFSARRVLL 89 F + +N V N SLPDI +W+ TA+++ + + G L +R+LL Sbjct: 24 FFSVLNEMVLNVSLPDIANDFNKPPASTNWVNTAFMLTFSIGTAVYGKLSDQLGIKRLLL 83 Query: 90 VGATGFLAFSLACSVAPS-ISTMIIARALQGAFGGVLIPLSFQLIVTELPPSKHPLGMAL 148 G S+ V S S +I+AR +QGA L ++ +P L Sbjct: 84 FGIIINCFGSVIGFVGHSFFSLLIMARFIQGAGAAAFPALVMVVVARYIPKENRGKAFGL 143 Query: 149 FAIANNVAQAAGPSVGGWLTDMYSWRWIFYLQIPPAIALVAAIGWAIRPVPVQLGMLRRA 208 + + GP++GG + W ++ + + + + + ++ + ++ + Sbjct: 144 IGSIVAMGEGVGPAIGGMIAHYIHWSYLLLI----PMITIITVPFLMKLLKKEVRIKGHF 199 Query: 209 DWFGIATMAVGLSALQIVLEEGGRKDWFASDLIVELSIVAALGLAAFVAIELRRKEPFIN 268 D GI M+VG+ + F + + IV+ L FV + +PF++ Sbjct: 200 DIKGIILMSVGIVFFML----------FTTSYSISFLIVSVLSFLIFVKHIRKVTDPFVD 249 Query: 269 LRLLGQYNFGIASLMQFLFGAVVFGVVFLVPNYFAELHGYSARDIG-LAMIPYGLVQFAM 327 L F I L + V G V +VP ++H S +IG + + P + Sbjct: 250 PGLGKNIPFMIGVLCGGIIFGTVAGFVSMVPYMMKDVHQLSTAEIGSVIIFPGTMSVIIF 309 Query: 328 SFLTPPLMRRTSPRTTIVLGFVLVAAGCLMNIHLDADAASNVIVPSLIVRGIGQSFVVIA 387 ++ L+ R P + +G ++ L L + S + ++ G SF Sbjct: 310 GYIGGILVDRRGPLYVLNIGVTFLSVSFLTASFLL-ETTSWFMTIIIVFVLGGLSFTKTV 368 Query: 388 LAVMAVDGIEKAQLGSASGVFNMVRNVGGAIGIAVMSQIV 427 ++ + +++ + G+ + N + GIA++ ++ Sbjct: 369 ISTIVSSSLKQQEAGAGMSLLNFTSFLSEGTGIAIVGGLL 408
>PF06580#Sensor histidine kinase Length = 349 Score = 30.2 bits (68), Expect = 0.016 Identities = 16/82 (19%), Positives = 30/82 (36%), Gaps = 14/82 (17%) Query: 395 GEIRVSGARDGRHYRFSVTDTGPGVPDDALPRLFEPFFTTRTDGLGLGLPLCDTLAQR-- 452 G+I + G +D V +TG + T + G GL + + L Sbjct: 279 GKILLKGTKDNGTVTLEVENTGSLALKN----------TKESTGTGLQN-VRERLQMLYG 327 Query: 453 QDGALTIRNLPSGGAEAVLLLP 474 + + + G A++L+P Sbjct: 328 TEAQIKLSEKQ-GKVNAMVLIP 348
>HTHFIS#FIS bacterial regulatory protein HTH signature. Length = 484 Score = 95.7 bits (238), Expect = 3e-25 Identities = 38/150 (25%), Positives = 63/150 (42%), Gaps = 1/150 (0%) Query: 16 VAIVDDDEAVRDGLALLLWTVGLRTRRFADAHAFLAEADDSTLGCVLLDLRMPGMSGLDA 75 + + DDD A+R L L G R ++A V+ D+ MP + D Sbjct: 6 ILVADDDAAIRTVLNQALSRAGYDVRITSNAATLWRWIAAGDGDLVVTDVVMPDENAFDL 65 Query: 76 LDCLAGRRS-LPVIVLTGHGNVDACRRAFKRGACDFLRKPVDDDELIDVVQQALRGHADR 134 L + R LPV+V++ +A ++GA D+L KP D ELI ++ +AL R Sbjct: 66 LPRIKKARPDLPVLVMSAQNTFMTAIKASEKGAYDYLPKPFDLTELIGIIGRALAEPKRR 125 Query: 135 RDGDAAEQARASRMATLSARERDVLDGIVR 164 + + SA +++ + R Sbjct: 126 PSKLEDDSQDGMPLVGRSAAMQEIYRVLAR 155
>TCRTETB#Tetracycline resistance protein TetB signature. Length = 458 Score = 64.5 bits (157), Expect = 2e-13 Identities = 35/138 (25%), Positives = 64/138 (46%), Gaps = 2/138 (1%) Query: 40 VPEMPSALHTSPAMVQLTLSVYMVVLGLGQLMFGPLSDRLGRRPVLLGGALLFSVASLAL 99 +P++ + + PA + +M+ +G ++G LSD+LG + +LL G ++ S+ Sbjct: 37 LPDIANDFNKPPASTNWVNTAFMLTFSIGTAVYGKLSDQLGIKRLLLFGIIINCFGSVIG 96 Query: 100 AMAGSG-GVFVALRLLQALGASAALVATFATVRDVYADRPEGSTLYSQFGAILAFVPALG 158 + S + + R +Q GA AA A V Y + + G+I+A +G Sbjct: 97 FVGHSFFSLLIMARFIQGAGA-AAFPALVMVVVARYIPKENRGKAFGLIGSIVAMGEGVG 155 Query: 159 PMLGAGIAHGFGWRAIFM 176 P +G IAH W + + Sbjct: 156 PAIGGMIAHYIHWSYLLL 173
>cloacin#Cloacin signature. Length = 551 Score = 33.1 bits (75), Expect = 0.002 Identities = 35/111 (31%), Positives = 49/111 (44%), Gaps = 11/111 (9%) Query: 248 GTLTGGLGGGSSSGSGGTSGTSSGGPLAPITGLLGTVTGALGGIGSSGTSGTGGTSGTGG 307 G G+GGG+S GSG +S + G G + G SG GG +GG Sbjct: 23 GPTGLGVGGGASDGSGWSSENNPWG---------GGSGSGIHWGGGSGHGNGGGNGNSGG 73 Query: 308 TSGTGGAGLGGLLAPVTNLVNSLTPLGASLTGTVTTPGGNLSGTLGGVLTS 358 SGTGG L + APV +L+ GA V+ G LS + ++ + Sbjct: 74 GSGTGG-NLSAVAAPVAFGFPALSTPGAGGLA-VSISAGALSAAIADIMAA 122 Score = 32.8 bits (74), Expect = 0.003 Identities = 36/131 (27%), Positives = 50/131 (38%), Gaps = 14/131 (10%) Query: 250 LTGGLGGGSSSGSGGTSGTSSGGPLAPITGLLGTVTGALGGIGSSGT---------SGTG 300 ++GG G G ++G+ TSG +GGP LG GA G G S SG Sbjct: 1 MSGGDGRGHNTGAHSTSGNINGGP-----TGLGVGGGASDGSGWSSENNPWGGGSGSGIH 55 Query: 301 GTSGTGGTSGTGGAGLGGLLAPVTNLVNSLTPLGASLTGTVTTPGGNLSGTLGGVLTSGP 360 G+G +G G GG NL P+ T G L+ ++ S Sbjct: 56 WGGGSGHGNGGGNGNSGGGSGTGGNLSAVAAPVAFGFPALSTPGAGGLAVSISAGALSAA 115 Query: 361 VGTLTGALGTP 371 + + AL P Sbjct: 116 IADIMAALKGP 126 Score = 30.8 bits (69), Expect = 0.011 Identities = 28/115 (24%), Positives = 43/115 (37%) Query: 165 GGVTLLGTPLNGLLSTLGSGLGLAGTKVGGATDNPVGAGLGGVVTQLGNTVTSTGGLVHD 224 G +NG + LG G G + + +NP G G G + G + GG + Sbjct: 11 TGAHSTSGNINGGPTGLGVGGGASDGSGWSSENNPWGGGSGSGIHWGGGSGHGNGGGNGN 70 Query: 225 NNAGSSSSGTGGSNPLAPITGLLGTLTGGLGGGSSSGSGGTSGTSSGGPLAPITG 279 + GS + G + G T G GG + S S G + +A + G Sbjct: 71 SGGGSGTGGNLSAVAAPVAFGFPALSTPGAGGLAVSISAGALSAAIADIMAALKG 125
>DHBDHDRGNASE#2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase signature. Length = 261 Score = 65.5 bits (159), Expect = 2e-14 Identities = 49/193 (25%), Positives = 82/193 (42%), Gaps = 2/193 (1%) Query: 2 KGFSGKVAAITGAGSGMGRSLAVELARRGCEVALADVSETGLAGTAAACAQHGVRVSTRR 61 KG GK+A ITGA G+G ++A LA +G +A D + L ++ Sbjct: 4 KGIEGKIAFITGAAQGIGEAVARTLASQGAHIAAVDYNPEKLEKVVSSLKAEARHAEAFP 63 Query: 62 LDVADRDAVFAWADFVRAEHGKVNLIFNNAGVSLAASAETARLADLEWIVGINFWGVVHG 121 DV D A+ + E G ++++ N AGV + + E +N GV + Sbjct: 64 ADVRDSAAIDEITARIEREMGPIDILVNVAGVLRPGLIHSLSDEEWEATFSVNSTGVFNA 123 Query: 122 TQAFLPHLRASGDGHVVNTSSLFGLVAMPTQSAYNATKFAVRGFTEALRMELELDGAPVS 181 +++ ++ G +V S V + +AY ++K A FT+ L +EL + Sbjct: 124 SRSVSKYMMDRRSGSIVTVGSNPAGVPRTSMAAYASSKAAAVMFTKCLGLELA--EYNIR 181 Query: 182 ATCVHPGGVATSI 194 V PG T + Sbjct: 182 CNIVSPGSTETDM 194
>HTHTETR#TetR bacterial regulatory protein HTH signature. Length = 215 Score = 55.8 bits (134), Expect = 8e-12 Identities = 24/179 (13%), Positives = 48/179 (26%), Gaps = 15/179 (8%) Query: 27 RAAERRDALIRAATRVFGTVGFRKATVRSICQEAKLNDRYFYAAFDSTEDLLRCTYLHHA 86 A E R ++ A R+F G ++ I + A + Y F DL + Sbjct: 8 EAQETRQHILDVALRLFSQQGVSSTSLGEIAKAAGVTRGAIYWHFKDKSDLFSEIWELSE 67 Query: 87 QQLHDAVAQAVAARGGELRERVDAGLAAFFAFLRDPCAARVLLLEVMGVSADT------- 139 + + + A G+ + L R LL+E++ + Sbjct: 68 SNIGELELEYQAKFPGDPLSVLREILIHVLESTVTE-ERRRLLMEIIFHKCEFVGEMAVV 126 Query: 140 ----DMTYQRMLIDFGKLIMAIGAPGEAVTPAERTEQRLIGLALVGAMTNVGAAWLLTD 194 + + R + + G ++ + WL Sbjct: 127 QQAQRNLCLESYDRIEQTLKHCIEAKMLPAD---LMTRRAAIIMRGYISGLMENWLFAP 182
>RTXTOXIND#Gram-negative bacterial RTX secretion protein D signature. Length = 478 Score = 52.5 bits (126), Expect = 2e-09 Identities = 33/210 (15%), Positives = 74/210 (35%), Gaps = 30/210 (14%) Query: 223 ASTDLADRRSELLTAERRLSGARATYERERTLWKERISAEQDYQQAQVQLREAEIAVQNA 282 A +L +S+L E + A+ Y+ L+K I +Q + + + Sbjct: 264 AVNELRVYKSQLEQIESEILSAKEEYQLVTQLFKNEIL--DKLRQTTDNIGLLTLELAKN 321 Query: 283 RQKLAALNAPVGAGALNRYELRAPFAGTIVE-KHATPGEAI-AADASMFVISDLSTVWAE 340 ++ +RAP + + + K T G + A+ M ++ + T+ Sbjct: 322 EERQQ------------ASVIRAPVSVKVQQLKVHTEGGVVTTAETLMVIVPEDDTLEVT 369 Query: 341 MAVPAQRLNDVRVGRDATVSATAFESRSSGPI----AYVG--SLLGEQTRT-APARVVLP 393 V + + + VG++A + AF G + + ++ ++ + + Sbjct: 370 ALVQNKDIGFINVGQNAIIKVEAFPYTRYGYLVGKVKNINLDAIEDQRLGLVFNVIISIE 429 Query: 394 -------NPDRVWRPGMFVNVSVDAGRQAV 416 N + GM V + G ++V Sbjct: 430 ENCLSTGNKNIPLSSGMAVTAEIKTGMRSV 459 Score = 38.7 bits (90), Expect = 4e-05 Identities = 23/132 (17%), Positives = 46/132 (34%), Gaps = 11/132 (8%) Query: 181 PGEIKFNEDRTAHVVPRVAGIVEQVSVSLGQNVAKGQVLAVIASTDLADRRSELLTAERR 240 G++ + + P IV+++ V G++V KG VL + + ++ L + Sbjct: 87 NGKLTHSGRSKE-IKPIENSIVKEIIVKEGESVRKGDVLLKLTALGA---EADTLKTQSS 142 Query: 241 LSGARATYERERTLWKE-------RISAEQDYQQAQVQLREAEIAVQNARQKLAALNAPV 293 L AR R + L + + + V E +++ + Sbjct: 143 LLQARLEQTRYQILSRSIELNKLPELKLPDEPYFQNVSEEEVLRLTSLIKEQFSTWQNQK 202 Query: 294 GAGALNRYELRA 305 LN + RA Sbjct: 203 YQKELNLDKKRA 214
>ACRIFLAVINRP#Acriflavin resistance protein family signature. Length = 1034 Score = 819 bits (2116), Expect = 0.0 Identities = 234/1065 (21%), Positives = 433/1065 (40%), Gaps = 62/1065 (5%) Query: 5 LIRFAIAHRWLVMLAIAAVAALGVFSYQRLPIDAVPDITNVQVQINTSAPGYSPLEAEQR 64 + F I + + G + +LP+ P I V ++ + PG + Sbjct: 1 MANFFIRRPIFAWVLAIILMMAGALAILQLPVAQYPTIAPPAVSVSANYPGADAQTVQDT 60 Query: 65 ITYPVETVMAGLPGLEQTRSIS-RYGLSQVTVIFKDGTDIYFARQLVNERIQEAKDKLPP 123 +T +E M G+ L S S G +T+ F+ GTD A+ V ++Q A LP Sbjct: 61 VTQVIEQNMNGIDNLMYMSSTSDSAGSVTITLTFQSGTDPDIAQVQVQNKLQLATPLLPQ 120 Query: 124 GIAPAMGPTSTGLGEIYLWTVEADANARKPDGTRYTAADLRELQDWVVRPQLRNVRGVTE 183 + YL D T D+ + V+ L + GV + Sbjct: 121 EVQQQGISVEKSSS-SYLMVA-----GFVSDNPGTTQDDISDYVASNVKDTLSRLNGVGD 174 Query: 184 VNSIGGYVKEYRVAPNPAKLMSYGLTLADVVRALERNNDNVGAGYI------EKRGEQYL 237 V G R+ + L Y LT DV+ L+ ND + AG + + Sbjct: 175 VQLFGAQ-YAMRIWLDADLLNKYKLTPVDVINQLKVQNDQIAAGQLGGTPALPGQQLNAS 233 Query: 238 VRVPGQARTVDDIANIVL-TNVGGVPVRMKDVGVVDIGRELRTGAATSNGEEVVLGTVFM 296 + + + ++ + L N G VR+KDV V++G E A NG+ + + Sbjct: 234 IIAQTRFKNPEEFGKVTLRVNSDGSVVRLKDVARVELGGENYNVIARINGKPAAGLGIKL 293 Query: 297 LMGENSRTVSKAVAAKMEDVNRTLPAGVKAIPVYDRTVLVEKAVATVKKNLLEGAVLVIA 356 G N+ +KA+ AK+ ++ P G+K + YD T V+ ++ V K L E +LV Sbjct: 294 ATGANALDTAKAIKAKLAELQPFFPQGMKVLYPYDTTPFVQLSIHEVVKTLFEAIMLVFL 353 Query: 357 VLFLFLGNIRAALITALVIPLSMLMTFTGMVNAKVSANLMSLG--ALDFGIIVDGAVVIV 414 V++LFL N+RA LI + +P+ +L TF + S N +++ L G++VD A+V+V Sbjct: 354 VMYLFLQNMRATLIPTIAVPVVLLGTFAILAAFGYSINTLTMFGMVLAIGLLVDDAIVVV 413 Query: 415 ENCVRRLAHAQSAAGRPLTRDERFAEVFGASQEARRALIFGQLIIMVVYLPIFALTGVEG 474 EN R + + + + + AL+ +++ V++P+ G G Sbjct: 414 ENVERVMMEDKLP---------PKEATEKSMSQIQGALVGIAMVLSAVFIPMAFFGGSTG 464 Query: 475 KMFHPMAITVVMALAAAMVLTVTFIPAAVALFIGERVE---EKENRLMGWARRA------ 525 ++ +IT+V A+A ++++ + PA A + E + GW Sbjct: 465 AIYRQFSITIVSAMALSVLVALILTPALCATLLKPVSAEHHENKGGFFGWFNTTFDHSVN 524 Query: 526 -YEPVLAAFMTRPARVMIGAGAIVLVTLGLATRLGSEFIPSLNEGDLAVSALRIPGTSLS 584 Y + + R ++ IV + L RL S F+P ++G G + Sbjct: 525 HYTNSVGKILGSTGRYLLIYALIVAGMVVLFLRLPSSFLPEEDQGVFLTMIQLPAGATQE 584 Query: 585 QSVE-MQKSIEKTLKARFPEIERVFARTGTAEIAADPMPPNLSDGYIMLKPADTWPDPKK 643 ++ + + + + LK +E VF G + N ++ LKP + + Sbjct: 585 RTQKVLDQVTDYYLKNEKANVESVFTVNG---FSFSGQAQNAGMAFVSLKPWEERNGDEN 641 Query: 644 PRDQLVREIEEALAELP-GNAYEFSQPIQLRFNELISGVRSDVA-VKIFGDDMAVLNQTG 701 + ++ + L ++ G F+ P EL + D + G L Q Sbjct: 642 SAEAVIHRAKMELGKIRDGFVIPFNMP---AIVELGTATGFDFELIDQAGLGHDALTQAR 698 Query: 702 EQIAAALQKVPGA-SEVKVEQTTGLPVLTVNLDRDKLARYGVSVADLQDSVAAAVGGQKA 760 Q+ + P + V+ + +D++K GVS++D+ +++ A+GG Sbjct: 699 NQLLGMAAQHPASLVSVRPNGLEDTAQFKLEVDQEKAQALGVSLSDINQTISTALGGTYV 758 Query: 761 GTLFQGDRRFDIVVRLPDELRSDIEAIKRLPIALPAPAAGASAPLAAAPYVPLAELATID 820 R + V+ + R E + +L + A VP + T Sbjct: 759 NDFIDRGRVKKLYVQADAKFRMLPEDVDKLYV-----------RSANGEMVPFSAFTTSH 807 Query: 821 VAPGPNQISREDGKRRVVVSANVRGRDVGSFVADAREQLQQ-DVRVPAGYWVSWGGQFEQ 879 G ++ R +G + + G+ DA ++ ++PAG W G Q Sbjct: 808 WVYGSPRLERYNGLPSMEIQGEAAP---GTSSGDAMALMENLASKLPAGIGYDWTGMSYQ 864 Query: 880 LQSASERLKLVVPLALFMVFVLLFVMFNNVKDGLLVFTGIPFALSGGVVSLWLRGIPLSI 939 + + + +V ++ +VF+ L ++ + + V +P + G +++ L + Sbjct: 865 ERLSGNQAPALVAISFVVVFLCLAALYESWSIPVSVMLVVPLGIVGVLLAATLFNQKNDV 924 Query: 940 TAAVGFIALSGVAVLNGLVMISFIRNLRD-EGMPLDAAVHDGALTRLRPVLMTALVASLG 998 VG + G++ N ++++ F ++L + EG + A RLRP+LMT+L LG Sbjct: 925 YFMVGLLTTIGLSAKNAILIVEFAKDLMEKEGKGVVEATLMAVRMRLRPILMTSLAFILG 984 Query: 999 FLPMAFATGTGAEVQRPLATVVIGGILSSTALTLLVLPVLYRVSH 1043 LP+A + G G+ Q + V+GG++S+T L + +PV + V Sbjct: 985 VLPLAISNGAGSGAQNAVGIGVMGGMVSATLLAIFFVPVFFVVIR 1029 Score = 87.2 bits (216), Expect = 2e-19 Identities = 76/532 (14%), Positives = 154/532 (28%), Gaps = 56/532 (10%) Query: 2 FERLIRFAIAHRWLVMLAIAAVAALGVFSYQRLPIDAVPDITNVQVQINTSAPGYSPLEA 61 + + + +L A + A V + RLP +P+ P + E Sbjct: 526 YTNSVGKILGSTGRYLLIYALIVAGMVVLFLRLPSSFLPEEDQGVFLTMIQLPAGATQER 585 Query: 62 EQRITYPVETVMAGLPGLEQTRSISRYGLSQ---------VTVIFKDGTDIYFARQLVNE 112 Q++ V + G S V K + Sbjct: 586 TQKVLDQVTDYYLKNEKANVESVFTVNGFSFSGQAQNAGMAFVSLKPWEERNGDENSAEA 645 Query: 113 RIQEAKDKLPP----GIAPAMGPTSTGLGEIYLWTVEADANARKPDGTRYTAADLRELQD 168 I AK +L + P P LG A + L Sbjct: 646 VIHRAKMELGKIRDGFVIPFNMPAIVELG---------TATGFDFELIDQAGLGHDALTQ 696 Query: 169 WV---------VRPQLRNVRGVTEVNSIGGYVKEYRVAPNPAKLMSYGLTLADVVRALER 219 L +VR ++ ++++ + K + G++L+D+ + + Sbjct: 697 ARNQLLGMAAQHPASLVSVRPNGLEDT-----AQFKLEVDQEKAQALGVSLSDINQTIST 751 Query: 220 NNDNVGAGYIEKRGEQY--LVRVPGQAR-TVDDIANIVLTNVGGVPVRMKDVGVVDIGRE 276 RG V+ + R +D+ + + + G V Sbjct: 752 ALGGTYVNDFIDRGRVKKLYVQADAKFRMLPEDVDKLYVRSANGEMVPFSAFTTSHWV-- 809 Query: 277 LRTGAATSNGEEVVLGTVFMLMGENSRTVSKAVAAKMEDVNRTLPAGVKAIPVYDRTVLV 336 G+ + ++ + T S A ME++ LPAG+ + Sbjct: 810 --YGSPRLERYNGLP-SMEIQGEAAPGTSSGDAMALMENLASKLPAGI-GYDWTGMSYQE 865 Query: 337 EKAVATVKKNLLEGAVLVIAVLFLFLGNIRAALITALVIPLSMLMTFTGMVNAKVSANLM 396 + + V+V L + + LV+PL ++ ++ Sbjct: 866 RLSGNQAPALVAISFVVVFLCLAALYESWSIPVSVMLVVPLGIVGVLLAATLFNQKNDVY 925 Query: 397 SLGAL--DFGIIVDGAVVIVENCVRRLAHAQSAAGRPLTRDERFAEVFGASQEARRALIF 454 + L G+ A++IVE G+ + A + R ++ Sbjct: 926 FMVGLLTTIGLSAKNAILIVE----FAKDLMEKEGKGV-----VEATLMAVRMRLRPILM 976 Query: 455 GQLIIMVVYLPIFALTGVEGKMFHPMAITVVMALAAAMVLTVTFIPAAVALF 506 L ++ LP+ G + + I V+ + +A +L + F+P + Sbjct: 977 TSLAFILGVLPLAISNGAGSGAQNAVGIGVMGGMVSATLLAIFFVPVFFVVI 1028
>HTHFIS#FIS bacterial regulatory protein HTH signature. Length = 484 Score = 81.8 bits (202), Expect = 3e-20 Identities = 40/135 (29%), Positives = 63/135 (46%), Gaps = 1/135 (0%) Query: 3 RILIVEDEPKTGAYLRKGLTEAGYVVDWVEDGITGQHQAETEEYDLLVLDVMLPGQDGWT 62 IL+ +D+ L + L+ AGY V + T + DL+V DV++P ++ + Sbjct: 5 TILVADDDAAIRTVLNQALSRAGYDVRITSNAATLWRWIAAGDGDLVVTDVVMPDENAFD 64 Query: 63 LLQNLR-RSKSTPVLFLTARDDVGDRVKGLELGADDYLAKPFDFVELTARIKSILRRGQP 121 LL ++ PVL ++A++ +K E GA DYL KPFD EL I L + Sbjct: 65 LLPRIKKARPDLPVLVMSAQNTFMTAIKASEKGAYDYLPKPFDLTELIGIIGRALAEPKR 124 Query: 122 RDSNTLRVADLELDL 136 R S + + L Sbjct: 125 RPSKLEDDSQDGMPL 139
>ECOLNEIPORIN#E.coli/Neisseria porin superfamily signature. Length = 331 Score = 87.9 bits (218), Expect = 1e-21 Identities = 90/342 (26%), Positives = 124/342 (36%), Gaps = 46/342 (13%) Query: 14 LLTAAHAAHATEVTLYG----LFDTSLTVVWNADAQGRNLVGLGNGNLLGNRFGVKGAED 69 L A A +VTLYG +TS +V N G G +L G++ G KG ED Sbjct: 9 TLAALPVAAMADVTLYGTIKAGVETSRSVAHNGAQAASVETGTGIVDL-GSKIGFKGQED 67 Query: 70 LGGGLKAIFTLENGFNPNTGALGQGNRMFGRQAFVGLESARWGTLTLGRQYDALADV--- 126 LG GLKAI+ +E G + RQ+F+GL +G L +GR L D Sbjct: 68 LGNGLKAIWQVEQ----KASIAGTDSGWGNRQSFIGL-KGGFGKLRVGRLNSVLKDTGDI 122 Query: 127 -AWPITGDFYFGSVYATPGDVDNYDTSSRTDNAVKYTSPVVGGFQFVGMYALGGVAGKSG 185 W D+ + A P + S V+Y SP G YAL AG+ Sbjct: 123 NPWDSKSDYLGVNKIAEP---EARLIS------VRYDSPEFAGLSGSVQYALNDNAGRHN 173 Query: 186 AGQTWSAGLSYNHGPFDAAGGYYYAANRASLANGVRTGWNGTSDGTFDGSLVNGGYLSAK 245 +++ AG +Y +G F G Y + N G + Y S Sbjct: 174 -SESYHAGFNYKNGGFFVQYGGAYKRHHQVQENV--NIEKYQIHRLVSGYDNDALYAS-- 228 Query: 246 SIGIARGALRYTFAPFTIGIDYSNAQYKADAMTAFRSTQKYDTARGFFNYQATASLLVGV 305 A++ A N+Q + A A+R F N S G Sbjct: 229 ------VAVQQQDAKLVEENYSHNSQTEVAATLAYR----------FGNVTPRVSYAHGF 272 Query: 306 GYSYTKARGDTSATYHQVSAGADYVLSKRTDLYAVGAWQRAN 347 S+ + Y QV GA+Y SKRT W + Sbjct: 273 KGSFDATNYNN--DYDQVVVGAEYDFSKRTSALVSAGWLQEG 312
>TCRTETB#Tetracycline resistance protein TetB signature. Length = 458 Score = 33.3 bits (76), Expect = 0.002 Identities = 34/158 (21%), Positives = 58/158 (36%), Gaps = 1/158 (0%) Query: 53 LDSIARDFGVSQAAVGGVITATQLGCALALLFVVPLGDLLNRKRLIAVQLVLLSAACIGV 112 L IA DF A+ V TA L ++ L D L KRL+ +++ + Sbjct: 37 LPDIANDFNKPPASTNWVNTAFMLTFSIGTAVYGKLSDQLGIKRLLLFGIIINCFGSVIG 96 Query: 113 ATAPTRGALLAGMVAIGLLGTAMTQGLIACSAA-LAGAGERGRVVGAAQGGVVVGLLAAR 171 + +LL I G A L+ A RG+ G V +G Sbjct: 97 FVGHSFFSLLIMARFIQGAGAAAFPALVMVVVARYIPKENRGKAFGLIGSIVAMGEGVGP 156 Query: 172 SLAGVVTDIAGWRAVYLVSGALAIAMLVVLSRLLPDMR 209 ++ G++ W + L+ I + ++ L ++R Sbjct: 157 AIGGMIAHYIHWSYLLLIPMITIITVPFLMKLLKKEVR 194
>TCRTETB#Tetracycline resistance protein TetB signature. Length = 458 Score = 133 bits (335), Expect = 3e-36 Identities = 83/399 (20%), Positives = 157/399 (39%), Gaps = 21/399 (5%) Query: 39 LDVTIVNIALAHLAADLHLPVAGLQWVVDAYTLAFAVLMLSAGALGDRFGTRRLYVAGLL 98 L+ ++N++L +A D + P A WV A+ L F++ G L D+ G +RL + G++ Sbjct: 28 LNEMVLNVSLPDIANDFNKPPASTNWVNTAFMLTFSIGTAVYGKLSDQLGIKRLLLFGII 87 Query: 99 LFAFASLACGAAVAPA-MLIAARALQGVGAAAMLPNSLALLNDACRHDPRLRARAVSGWT 157 + F S+ + +LI AR +QG GAAA + ++ R +A Sbjct: 88 INCFGSVIGFVGHSFFSLLIMARFIQGAGAAAFPALVMVVVARYI--PKENRGKAFGLIG 145 Query: 158 AAGSIAIAAGPVVGGLLIAAWGWRGIFLVNLPLCAAGLAATFAWVPARREQAAPARSTRS 217 + ++ GP +GG++ W + L+ + R Sbjct: 146 SIVAMGEGVGPAIGGMIAHYIHWSYLLLIPMITIITVPFLMKLLKKE-------VRIKGH 198 Query: 218 LDPRGQFIAIAMLTVLTGAVIEWRPLGFTHPVVASGFVLAALAALAFVAVESRTATPMLP 277 D +G + + + FT S +++ L+ L FV + P + Sbjct: 199 FDIKGIILMSVGIVFF---------MLFTTSYSISFLIVSVLSFLIFVKHIRKVTDPFVD 249 Query: 278 LSLFRHPAFSTAVLFGICVNLTYYGTVFVLALYLQRARGESALQAGLAFL-PLTGGFLLS 336 L ++ F VL G + T G V ++ ++ S + G + P T ++ Sbjct: 250 PGLGKNIPFMIGVLCGGIIFGTVAGFVSMVPYMMKDVHQLSTAEIGSVIIFPGTMSVIIF 309 Query: 337 NLASGRVVARHGPRVPMVAGALVAALGYGSLHFVDAATPLGVLLVPFLLIPSGMGFAVPA 396 G +V R GP + G ++ + + F+ T + + + + G+ F Sbjct: 310 GYIGGILVDRRGPLYVLNIGVTFLSVSFLTASFLLETTSW-FMTIIIVFVLGGLSFTKTV 368 Query: 397 MTTAVLASVAPERAGIASAVLNTARQAGGAIGVAAFGAL 435 ++T V +S+ + AG ++LN G+A G L Sbjct: 369 ISTIVSSSLKQQEAGAGMSLLNFTSFLSEGTGIAIVGGL 407
>SACTRNSFRASE#Streptothricin acetyltransferase signature. Length = 173 Score = 44.6 bits (105), Expect = 2e-08 Identities = 17/55 (30%), Positives = 27/55 (49%) Query: 80 ITSLVVDESCRGQGVGGALIAAAHSWFESVGCVKLEVTSGDHRLDAHRFYARYGF 134 I + V + R +GVG AL+ A W + L + + D + A FYA++ F Sbjct: 92 IEDIAVAKDYRKKGVGTALLHKAIEWAKENHFCGLMLETQDINISACHFYAKHHF 146
>INFPOTNTIATR#Macrophage infectivity potentiator signature. Length = 233 Score = 92.7 bits (230), Expect = 1e-26 Identities = 46/111 (41%), Positives = 63/111 (56%), Gaps = 2/111 (1%) Query: 3 VITTESGLKYEDLTEGTGAEAQAGKTVSVHYTGWLTDGQKFDSSKDRNDPFAFVLGGGMV 62 ++ SGL+Y+ + GTGA+ TV+V YTG L DG FDS++ P F + V Sbjct: 121 IVVLPSGLQYKIIDAGTGAKPGKSDTVTVEYTGTLIDGTVFDSTEKAGKPATFQVS--QV 178 Query: 63 IKGWDEGVQGMKVGGVRRLTIPPQLGYGPRGAGGVIPPNATLVFEVELLDV 113 I GW E +Q M G + +P L YGPR GG I PN TL+F++ L+ V Sbjct: 179 IPGWTEALQLMPAGSTWEVFVPADLAYGPRSVGGPIGPNETLIFKIHLISV 229
>HTHFIS#FIS bacterial regulatory protein HTH signature. Length = 484 Score = 384 bits (989), Expect = e-132 Identities = 139/383 (36%), Positives = 202/383 (52%), Gaps = 40/383 (10%) Query: 104 FDYVTLPLPYEWISHVLGHARGMAALDRVDGAAYAASIGEHGMIGNCEAMQQLFSTIRKV 163 +DY+ P + ++G A +A R S ++G AMQ+++ + ++ Sbjct: 99 YDYLPKPFDLTELIGIIGRA--LAEPKRRPSKLEDDSQDGMPLVGRSAAMQEIYRVLARL 156 Query: 164 AKTDASVFISGESGTGKELTALAIHERSGRGKGPFVAINCGAIPHHLLQSELFGYERGAF 223 +TD ++ I+GESGTGKEL A A+H+ R GPFVAIN AIP L++SELFG+E+GAF Sbjct: 157 MQTDLTLMITGESGTGKELVARALHDYGKRRNGPFVAINMAAIPRDLIESELFGHEKGAF 216 Query: 224 TGANQRRAGRIESANGGTLFLDEIGDMPVESQASLLRFLQEGKIERLGGQESIVVDVRII 283 TGA R GR E A GGTLFLDEIGDMP+++Q LLR LQ+G+ +GG+ I DVRI+ Sbjct: 217 TGAQTRSTGRFEQAEGGTLFLDEIGDMPMDAQTRLLRVLQQGEYTTVGGRTPIRSDVRIV 276 Query: 284 SATHVDLDGAVEAGRFRADLYHRLCVLRIHEPPLRARGKDIDILAHYVLQKFKADSGRKI 343 +AT+ DL ++ G FR DLY+RL V+ + PPLR R +DI L + +Q+ + + G + Sbjct: 277 AATNKDLKQSINQGLFREDLYYRLNVVPLRLPPLRDRAEDIPDLVRHFVQQAEKE-GLDV 335 Query: 344 SGFTSAALDAMRRYEWPGNVRELINRVRRAIVMAESRLLTPHDLGLDTPGET-------- 395 F AL+ M+ + WPGNVREL N VRR + ++T + + E Sbjct: 336 KRFDQEALELMKAHPWPGNVRELENLVRRLTALYPQDVITREIIENELRSEIPDSPIEKA 395 Query: 396 -----------------------------EPVTLEQARALAERTAIENALLRNDHRINKA 426 ++ A E I AL KA Sbjct: 396 AARSGSLSISQAVEENMRQYFASFGDALPPSGLYDRVLAEMEYPLILAALTATRGNQIKA 455 Query: 427 AAELGISRVTLYRMMIEHGLNDH 449 A LG++R TL + + E G++ + Sbjct: 456 ADLLGLNRNTLRKKIRELGVSVY 478
>INTIMIN#Intimin signature. Length = 939 Score = 33.5 bits (76), Expect = 0.004 Identities = 24/100 (24%), Positives = 38/100 (38%), Gaps = 1/100 (1%) Query: 83 SARDTTADADETAVRTTHAPTVQPAVVQQPRVDIAGTANSMTKKLNEVSVEDDANQSDEQ 142 +A T+A AD T T A TV+ V Q V ++ S T L+ S + + Sbjct: 564 TADKTSAKADGTEAITYTA-TVKKNGVAQANVPVSFNIVSGTAVLSANSANTNGSGKATV 622 Query: 143 PAAAAAPGKSKVRDRRAKEKALLKEAFATSTPGTAEELEE 182 + PG+ V + A+ + L T + E Sbjct: 623 TLKSDKPGQVVVSAKTAEMTSALNANAVIFVDQTKASITE 662
>IGASERPTASE#IgA-specific serine endopeptidase (S6) signature. Length = 1541 Score = 53.5 bits (128), Expect = 2e-09 Identities = 30/179 (16%), Positives = 54/179 (30%), Gaps = 21/179 (11%) Query: 397 APEAFAQHRANAPHAEVPVPHPPGATHDTRQQAMQREHAAQETRAAAQQQQQQRAEMQRH 456 P + + A E PVP P AT + + + +Q Q Sbjct: 1007 VPSVPSNNEEIARVDEAPVPPPAPATPSETTETVAENSKQESKTVEKNEQDATETTAQNR 1066 Query: 457 DAAQQ-----REALQQRNAAQQQEHAQAQQRDEAQQQQRVEAQ--QRDEARQQQRS---- 505 + A++ + Q AQ + Q E ++ VE + + E + Q Sbjct: 1067 EVAKEAKSNVKANTQTNEVAQSGSETKETQTTETKETATVEKEEKAKVETEKTQEVPKVT 1126 Query: 506 --EAAQQQQRKEMQPHPEAPP--------REHAAPQPRQAAPEHAHAPHPAESHPPHES 554 + +Q+Q + +QP E +E + A E + P Sbjct: 1127 SQVSPKQEQSETVQPQAEPARENDPTVNIKEPQSQTNTTADTEQPAKETSSNVEQPVTE 1185 Score = 41.6 bits (97), Expect = 9e-06 Identities = 27/188 (14%), Positives = 50/188 (26%), Gaps = 38/188 (20%) Query: 397 APEAFAQHRANAPHAEVPVPHPPGATHDTRQQAMQREHAAQETRAAAQQ----------- 445 A E AQ+R A A+ V + + +E ET+ A Sbjct: 1058 ATETTAQNREVAKEAKSNVKANTQTNEVAQSGSETKETQTTETKETATVEKEEKAKVETE 1117 Query: 446 QQQQRAEMQRHDAAQQREALQQRNAAQ-QQEHAQAQQRDEAQQQQRVEAQQRDEARQQQR 504 + Q+ ++ + +Q ++ + A+ +E+ E Q Q A A++ Sbjct: 1118 KTQEVPKVTSQVSPKQEQSETVQPQAEPARENDPTVNIKEPQSQTNTTADTEQPAKETSS 1177 Query: 505 --------------------------SEAAQQQQRKEMQPHPEAPPREHAAPQPRQAAPE 538 Q E P+ R P P Sbjct: 1178 NVEQPVTESTTVNTGNSVVENPENTTPATTQPTVNSESSNKPKNRHRRSVRSVPHNVEPA 1237 Query: 539 HAHAPHPA 546 + + Sbjct: 1238 TTSSNDRS 1245 Score = 36.2 bits (83), Expect = 5e-04 Identities = 20/158 (12%), Positives = 41/158 (25%), Gaps = 8/158 (5%) Query: 401 FAQHRANAPHAEVPVPHPPGATHDTRQQAMQREHAAQETRAAAQQQQQQRAEMQRHDAAQ 460 + + V T + Q + + E A + Sbjct: 978 YDLYNPEVEKRNQTVDTTNITTPNNIQADVPSVPSNNEEIARVDEAPVPPPAPATPSETT 1037 Query: 461 QREALQQRNAAQQQEHAQAQQRDEAQQQQRV--EAQQRDEARQQQRSEAAQQQQRKEMQP 518 + A + ++ E + + Q + V EA+ +A Q +E AQ + Sbjct: 1038 ETVAENSKQESKTVEKNEQDATETTAQNREVAKEAKSNVKANTQT-NEVAQSGSETK--- 1093 Query: 519 HPEAPPREHAAPQPRQAAPEHAHAPHPAESHPPHESRE 556 E E + + + P S+ Sbjct: 1094 --ETQTTETKETATVEKEEKAKVETEKTQEVPKVTSQV 1129
>SUBTILISIN#Subtilisin serine protease family (S8) signature. Length = 326 Score = 44.8 bits (106), Expect = 6e-07 Identities = 51/243 (20%), Positives = 75/243 (30%), Gaps = 40/243 (16%) Query: 302 TDTDGTVEWNLDSQSIVGAAGG----SVKQVVFYVAPSMTLTAITAAYNKAVTDNVAKVI 357 T GT+ + +VG A +K V S I A+ V +I Sbjct: 88 THVAGTIAATENENGVVGVAPEADLLIIK--VLNKQGSGQYDWIIQGIYYAIEQKV-DII 144 Query: 358 NVSLGVCESSANSTGSQATDDTIFKQAVAQGQTFSVSAGDHGAYECASGTPSRSTYTVSE 417 ++SLG K+AVA +AG+ G + T + Sbjct: 145 SMSLG-------GPEDVPELHEAVKKAVASQILVMCAAGNEGDGDD-------RTDELGY 190 Query: 418 PATSPYVIAVGGTTLFTNTSTNAYNSEIVWNDPSWQPGT-VWST--GGGYSKYE----AA 470 P VI+VG + S PG + ST GG Y+ + A Sbjct: 191 PGCYNEVISVGAINF---DRHASEFSNSNNEVDLVAPGEDILSTVPGGKYATFSGTSMAT 247 Query: 471 P------TWQSSTLTGSTKRALPDVGFDADLRTGAILVVNGQTSDTLWGSGYLNNEGGTS 524 P S +R L + A L I + N S + G+G L Sbjct: 248 PHVAGALALIKQLANASFERDLTEPELYAQLIKRTIPLGN---SPKMEGNGLLYLTAVEE 304 Query: 525 LAA 527 L+ Sbjct: 305 LSR 307
>HTHFIS#FIS bacterial regulatory protein HTH signature. Length = 484 Score = 86.8 bits (215), Expect = 6e-22 Identities = 43/182 (23%), Positives = 85/182 (46%), Gaps = 16/182 (8%) Query: 1 MTNSLILIAEDEPDISDILDAYLKHDGFRTYRVADGQAVLDMQPHLKPDLILLDVKMPRK 60 MT + IL+A+D+ I +L+ L G+ ++ + DL++ DV MP + Sbjct: 1 MTGATILVADDDAAIRTVLNQALSRAGYDVRITSNAATLWRWIAAGDGDLVVTDVVMPDE 60 Query: 61 NGWDVLAELRRRD-NTPVVVLTAFDRDLDRLQALHAGADDYIVKPFNPAEVVARL-RAIL 118 N +D+L +++ + PV+V++A + + ++A GA DY+ KPF+ E++ + RA+ Sbjct: 61 NAFDLLPRIKKARPDLPVLVMSAQNTFMTAIKASEKGAYDYLPKPFDLTELIGIIGRALA 120 Query: 119 RRSAAPPTLRMLRVGDLEIDTDSYLARVRTAGTEVPITLTLTEFRLLAHMARSPSRVFTR 178 P L + + S A ++ +R+LA + ++ + Sbjct: 121 EPKRRPSKLEDDSQDGMPLVGRS--AAMQEI------------YRVLARLMQTDLTLMIT 166 Query: 179 GE 180 GE Sbjct: 167 GE 168
>ACRIFLAVINRP#Acriflavin resistance protein family signature. Length = 1034 Score = 1090 bits (2821), Expect = 0.0 Identities = 532/1028 (51%), Positives = 718/1028 (69%), Gaps = 7/1028 (0%) Query: 1 MAEFFIRRPVFAWVIALFIILTGLIAIPQLPVARYPSVAPPSVTITASYPGATPQTMNDG 60 MA FFIRRP+FAWV+A+ +++ G +AI QLPVA+YP++APP+V+++A+YPGA QT+ D Sbjct: 1 MANFFIRRPIFAWVLAIILMMAGALAILQLPVAQYPTIAPPAVSVSANYPGADAQTVQDT 60 Query: 61 VLSLIERELSGVKNLLYFESSADTSGQAQITVTFKPGTNPEMAQVDVQNKIKSVEPRLPA 120 V +IE+ ++G+ NL+Y S++D++G IT+TF+ GT+P++AQV VQNK++ P LP Sbjct: 61 VTQVIEQNMNGIDNLMYMSSTSDSAGSVTITLTFQSGTDPDIAQVQVQNKLQLATPLLPQ 120 Query: 121 AVRQNGLIVESASSGFLMIVSLRSDNGRFDEGALADYMARSVSEELRRIDGVGRVLQFGS 180 V+Q G+ VE +SS +LM+ SDN + ++DY+A +V + L R++GVG V FG+ Sbjct: 121 EVQQQGISVEKSSSSYLMVAGFVSDNPGTTQDDISDYVASNVKDTLSRLNGVGDVQLFGA 180 Query: 181 ERAMRIWVDPQKLINFGLSMSDLTTAIGQQNVQIAPGSLGALPALPGQRVTVPLTAQGQL 240 + AMRIW+D L + L+ D+ + QN QIA G LG PALPGQ++ + AQ + Sbjct: 181 QYAMRIWLDADLLNKYKLTPVDVINQLKVQNDQIAAGQLGGTPALPGQQLNASIIAQTRF 240 Query: 241 TTPEAFAKVVLRANADGSKVVLGDVARVELGSQNYTFVSRENNKPATLAGVQLAPGANAV 300 PE F KV LR N+DGS V L DVARVELG +NY ++R N KPA G++LA GANA+ Sbjct: 241 KNPEEFGKVTLRVNSDGSVVRLKDVARVELGGENYNVIARINGKPAAGLGIKLATGANAL 300 Query: 301 KTADAIRARMAELSKSMPSGMSYSIPLDTSPFVKISIEKVLHTLLEAMVLVFLVMYLFLQ 360 TA AI+A++AEL P GM P DT+PFV++SI +V+ TL EA++LVFLVMYLFLQ Sbjct: 301 DTAKAIKAKLAELQPFFPQGMKVLYPYDTTPFVQLSIHEVVKTLFEAIMLVFLVMYLFLQ 360 Query: 361 NVRYTLIPAIVAPVAMLGTFTVMLLTGFSINVLTMFGMVLAIGIIVDDAIVVVENVERLM 420 N+R TLIP I PV +LGTF ++ G+SIN LTMFGMVLAIG++VDDAIVVVENVER+M Sbjct: 361 NMRATLIPTIAVPVVLLGTFAILAAFGYSINTLTMFGMVLAIGLLVDDAIVVVENVERVM 420 Query: 421 AEEGLSPKDATSKAMKEITGAIIGVTLVLTAVFLPMAMASGSVGVIYKQFTLSMAVSILF 480 E+ L PK+AT K+M +I GA++G+ +VL+AVF+PMA GS G IY+QF++++ ++ Sbjct: 421 MEDKLPPKEATEKSMSQIQGALVGIAMVLSAVFIPMAFFGGSTGAIYRQFSITIVSAMAL 480 Query: 481 SALLALTLTPALCATMLKPIAAGHHE-KRGFFGWFNRRFDRLTKWYETRVGRLVGRTGRV 539 S L+AL LTPALCAT+LKP++A HHE K GFFGWFN FD Y VG+++G TGR Sbjct: 481 SVLVALILTPALCATLLKPVSAEHHENKGGFFGWFNTTFDHSVNHYTNSVGKILGSTGRY 540 Query: 540 MLVFVAISGALVLGFRSLPSSFLPDEDQGYFITSFLLPADATAERTHDVVKTLEKHL--A 597 +L++ I +V+ F LPSSFLP+EDQG F+T LPA AT ERT V+ + + Sbjct: 541 LLIYALIVAGMVVLFLRLPSSFLPEEDQGVFLTMIQLPAGATQERTQKVLDQVTDYYLKN 600 Query: 598 SRPAIQSSISVIGYGFSGQGSNAAINWSVMKDWKNRGGASTIEEGML--AQQAMAGVTEG 655 + ++S +V G+ FSGQ NA + + +K W+ R G E ++ A+ + + +G Sbjct: 601 EKANVESVFTVNGFSFSGQAQNAGMAFVSLKPWEERNGDENSAEAVIHRAKMELGKIRDG 660 Query: 656 TVMSLLPPAIDELGNSSGFSMRLEDRANQGAAALKAAEVKLLELAAQSKV-VTGVYPDSL 714 V+ PAI ELG ++GF L D+A G AL A +LL +AAQ + V P+ L Sbjct: 661 FVIPFNMPAIVELGTATGFDFELIDQAGLGHDALTQARNQLLGMAAQHPASLVSVRPNGL 720 Query: 715 PAGTSIRLEIDRAKAQALGVSFTTLSDTLSTAMGSTYVNDFPNAGRMQQVIIQADAPARM 774 +LE+D+ KAQALGVS + ++ T+STA+G TYVNDF + GR++++ +QADA RM Sbjct: 721 EDTAQFKLEVDQEKAQALGVSLSDINQTISTALGGTYVNDFIDRGRVKKLYVQADAKFRM 780 Query: 775 QIDNVMKLYVRNAAGGMVPLSEVVRPVWTDTPLQMVRFKGYPSARIAGNAAPGQSSGAAM 834 ++V KLYVR+A G MVP S W ++ R+ G PS I G AAPG SSG AM Sbjct: 781 LPEDVDKLYVRSANGEMVPFSAFTTSHWVYGSPRLERYNGLPSMEIQGEAAPGTSSGDAM 840 Query: 835 AEMERLAAQLPPGFAVEWTGQSLQERQSASQAPMLMVLSMIVVFLVLAALYESWSIPLSV 894 A ME LA++LP G +WTG S QER S +QAP L+ +S +VVFL LAALYESWSIP+SV Sbjct: 841 ALMENLASKLPAGIGYDWTGMSYQERLSGNQAPALVAISFVVVFLCLAALYESWSIPVSV 900 Query: 895 MLVVPLGLIGAIGAVLLRGMPNDVFFKVGMITVIGLSAKNAILIVEFAKQLRE-EGKGLI 953 MLVVPLG++G + A L NDV+F VG++T IGLSAKNAILIVEFAK L E EGKG++ Sbjct: 901 MLVVPLGIVGVLLAATLFNQKNDVYFMVGLLTTIGLSAKNAILIVEFAKDLMEKEGKGVV 960 Query: 954 EAAVQASKLRLRPILMTSLAFGLGVVPLMIATGASAETQHAIGTGVFGGMVTATVLAIFF 1013 EA + A ++RLRPILMTSLAF LGV+PL I+ GA + Q+A+G GV GGMV+AT+LAIFF Sbjct: 961 EATLMAVRMRLRPILMTSLAFILGVLPLAISNGAGSGAQNAVGIGVMGGMVSATLLAIFF 1020 Query: 1014 VPVFFVFV 1021 VPVFFV + Sbjct: 1021 VPVFFVVI 1028 Score = 80.7 bits (199), Expect = 2e-17 Identities = 57/323 (17%), Positives = 124/323 (38%), Gaps = 17/323 (5%) Query: 719 SIRLEIDRAKAQALGVSFTTLSDTLSTA---MGSTYVNDFPNA-GRMQQVIIQADAPARM 774 ++R+ +D ++ + + L + + + P G+ I A R Sbjct: 183 AMRIWLDADLLNKYKLTPVDVINQLKVQNDQIAAGQLGGTPALPGQQLNASIIAQT--RF 240 Query: 775 Q-IDNVMKLYVR-NAAGGMVPLSEVVRPVWTDTPLQ--MVRFKGYPSARIAGNAAPGQS- 829 + + K+ +R N+ G +V L +V R V + R G P+A + A G + Sbjct: 241 KNPEEFGKVTLRVNSDGSVVRLKDVAR-VELGGENYNVIARINGKPAAGLGIKLATGANA 299 Query: 830 ---SGAAMAEMERLAAQLPPGFAVEWT-GQSLQERQSASQAPMLMVLSMIVVFLVLAALY 885 + A A++ L P G V + + + S + + ++++VFLV+ Sbjct: 300 LDTAKAIKAKLAELQPFFPQGMKVLYPYDTTPFVQLSIHEVVKTLFEAIMLVFLVMYLFL 359 Query: 886 ESWSIPLSVMLVVPLGLIGAIGAVLLRGMPNDVFFKVGMITVIGLSAKNAILIVE-FAKQ 944 ++ L + VP+ L+G + G + GM+ IGL +AI++VE + Sbjct: 360 QNMRATLIPTIAVPVVLLGTFAILAAFGYSINTLTMFGMVLAIGLLVDDAIVVVENVERV 419 Query: 945 LREEGKGLIEAAVQASKLRLRPILMTSLAFGLGVVPLMIATGASAETQHAIGTGVFGGMV 1004 + E+ EA ++ ++ ++ +P+ G++ + M Sbjct: 420 MMEDKLPPKEATEKSMSQIQGALVGIAMVLSAVFIPMAFFGGSTGAIYRQFSITIVSAMA 479 Query: 1005 TATVLAIFFVPVFFVFVMSIQER 1027 + ++A+ P ++ Sbjct: 480 LSVLVALILTPALCATLLKPVSA 502
>RTXTOXIND#Gram-negative bacterial RTX secretion protein D signature. Length = 478 Score = 49.8 bits (119), Expect = 9e-09 Identities = 33/213 (15%), Positives = 74/213 (34%), Gaps = 32/213 (15%) Query: 43 AATRVDVTEDLPGRVAAV-RVAEIRPQVSGIVQRRLFEQGTEVRAGQPLFQINPAPFKAE 101 +V++ G++ R EI+P + IV+ + ++G VR G L ++ +A+ Sbjct: 76 VLGQVEIVATANGKLTHSGRSKEIKPIENSIVKEIIVKEGESVRKGDVLLKLTALGAEAD 135 Query: 102 MDTAAASLQRAQAALERAKVQ----------------TARFKPLVEADAISRQVYDDAVS 145 +SL +A+ R ++ F+ + E + + Sbjct: 136 TLKTQSSLLQARLEQTRYQILSRSIELNKLPELKLPDEPYFQNVSEEEVLRLTSL--IKE 193 Query: 146 QRDQAAADVAQARATLARRQLDLKFATVEAPIAGRIDQALVTEGALVSSSDSQPMA---- 201 Q Q L +++ + TV A I + + V + L D + Sbjct: 194 QFSTWQNQKYQKELNLDKKRAER--LTVLARINRYENLSRVEKSRL---DDFSSLLHKQA 248 Query: 202 ----RIQQIDQVYVDVRQPAASLEALRDALASQ 230 + + + YV+ ++ + + S+ Sbjct: 249 IAKHAVLEQENKYVEAVNELRVYKSQLEQIESE 281 Score = 29.0 bits (65), Expect = 0.034 Identities = 11/36 (30%), Positives = 18/36 (50%), Gaps = 1/36 (2%) Query: 61 RVAEIRPQVSGIVQR-RLFEQGTEVRAGQPLFQINP 95 + + IR VS VQ+ ++ +G V + L I P Sbjct: 326 QASVIRAPVSVKVQQLKVHTEGGVVTTAETLMVIVP 361
>TCRTETB#Tetracycline resistance protein TetB signature. Length = 458 Score = 86.9 bits (215), Expect = 2e-20 Identities = 66/400 (16%), Positives = 158/400 (39%), Gaps = 15/400 (3%) Query: 32 ALMATLDISITNSALPQIQGEIGATGTEGTWISTGYLMSEIVMIPLAAWLTRVFGLRNFL 91 + + L+ + N +LP I + W++T ++++ + + L+ G++ L Sbjct: 23 SFFSVLNEMVLNVSLPDIANDFNKPPASTNWVNTAFMLTFSIGTAVYGKLSDQLGIKRLL 82 Query: 92 LTNSALFIAFSMMCGWSHS-LPMMIAGRIGQGFTGGALIPTAQTIIRTRLPLSQLPVGMT 150 L + S++ HS ++I R QG A ++ +P Sbjct: 83 LFGIIINCFGSVIGFVGHSFFSLLIMARFIQGAGAAAFPALVMVVVARYIPKENRGKAFG 142 Query: 151 LFGLIVLLGPLFGPVLGGWLAENVNWSWCFFLNLPVCLLLMALLVFGLPSDRPQWSAFFN 210 L G IV +G GP +GG +A ++WS + L +P+ ++ + L + + + Sbjct: 143 LIGSIVAMGEGVGPAIGGMIAHYIHWS--YLLLIPMITIITVPFLMKLL--KKEVRIKGH 198 Query: 211 ADWLGILGLAIGLSSLTVVLEEGQRERWFESQMIVTLSIVSFIGMVLIALSQRFAKRPIM 270 D GI+ +++G+ + +L F + ++ IVS + ++ R P + Sbjct: 199 FDIKGIILMSVGI--VFFML--------FTTSYSISFLIVSVLSFLIFVKHIRKVTDPFV 248 Query: 271 RLSLMRNPRYASVIVIVSAVGAGLYGVSYLLPQFLAIVAGYNAEQAGAIMLLSGLPAFLV 330 L +N + ++ + + G ++P + V + + G++++ G + ++ Sbjct: 249 DPGLGKNIPFMIGVLCGGIIFGTVAGFVSMVPYMMKDVHQLSTAEIGSVIIFPGTMSVII 308 Query: 331 MPILPRLLGKVDFRILVITGLLLFCLSCMLDISLTAQSVGHDFVWSQLIRGLAQMLAMMP 390 + +L + V+ + F L S ++ + Sbjct: 309 FGYIGGILVDRRGPLYVLNIGVTFLSVSFLTASFLLETTSWFMTIIIVFVLGGLSFTKTV 368 Query: 391 LNQASMAAVAREDSGDAAGLYNMARNLGGSIGLAIIGTVI 430 ++ +++ ++++G L N L G+AI+G ++ Sbjct: 369 ISTIVSSSLKQQEAGAGMSLLNFTSFLSEGTGIAIVGGLL 408
>RTXTOXIND#Gram-negative bacterial RTX secretion protein D signature. Length = 478 Score = 129 bits (326), Expect = 1e-35 Identities = 56/370 (15%), Positives = 114/370 (30%), Gaps = 81/370 (21%) Query: 69 SMTAAPKVAGYVTDVYVRDNQPVKAGDPLVRLD-------VRQYQVALAQAQATV----- 116 S P V ++ V++ + V+ GD L++L + Q +L QA+ Sbjct: 96 SKEIKPIENSIVKEIIVKEGESVRKGDVLLKLTALGAEADTLKTQSSLLQARLEQTRYQI 155 Query: 117 ----------------------------------------DARRADIARAEADISQQRAN 136 + + E ++ ++RA Sbjct: 156 LSRSIELNKLPELKLPDEPYFQNVSEEEVLRLTSLIKEQFSTWQNQKYQKELNLDKKRAE 215 Query: 137 LEQADAQAKVSRINAQHASDEYTRYAPLAATGAETHERVADLKSTRDQAAATLAANNASI 196 A+ ++ ++ L A V + ++ +A L + + Sbjct: 216 RLTVLARINRYENLSRVEKSRLDDFSSLLHKQAIAKHAVLEQENKYVEAVNELRVYKSQL 275 Query: 197 AAARTQIASFTA---------------QLQQARAQLEAAQASAAQAQLDLDNTIVRSTLA 241 ++I S +L+Q + A+ + +++R+ ++ Sbjct: 276 EQIESEILSAKEEYQLVTQLFKNEILDKLRQTTDNIGLLTLELAKNEERQQASVIRAPVS 335 Query: 242 GRVGDRTVR-VGQYVQPGTRLLTVVPVDSIYLV-ANFKETQIGNMRIGQPVELHVDALPD 299 +V V G V L+ +VP D V A + IG + +GQ + V+A P Sbjct: 336 VKVQQLKVHTEGGVVTTAETLMVIVPEDDTLEVTALVQNKDIGFINVGQNAIIKVEAFPY 395 Query: 300 ---GPLSGVVDSFAPGTGAQFALLPPENATGNFTKIVQRVPVRIRLAANARAQRMLLPGL 356 G L G V + + G ++ + N L G+ Sbjct: 396 TRYGYLVGKVKNINLDA-------IEDQRLGLVFNVIISIEENCLSTGN--KNIPLSSGM 446 Query: 357 SVTVDVDTRS 366 +VT ++ T Sbjct: 447 AVTAEIKTGM 456
>HTHTETR#TetR bacterial regulatory protein HTH signature. Length = 215 Score = 63.1 bits (153), Expect = 5e-14 Identities = 20/93 (21%), Positives = 41/93 (44%), Gaps = 2/93 (2%) Query: 16 ARGDETRQRIIEAAIELFGERGFAGASTREIAAMAGVNAPALQYYFENKEGVYRACVETI 75 ETRQ I++ A+ LF ++G + S EIA AGV A+ ++F++K ++ E Sbjct: 7 QEAQETRQHILDVALRLFSQQGVSSTSLGEIAKAAGVTRGAIYWHFKDKSDLFSEIWELS 66 Query: 76 AEHGWQVFAPAVGHARAMLDGHASVDALIDAFI 108 + ++ + + ++ + Sbjct: 67 ESNIGELELEYQAKFPGDP--LSVLREILIHVL 97
>PYOCINKILLER#Pyocin S killer protein signature. Length = 617 Score = 30.9 bits (69), Expect = 0.024 Identities = 37/177 (20%), Positives = 60/177 (33%), Gaps = 18/177 (10%) Query: 9 LLAAVVSAAHAAAPAPAAASAASGAAPALTPQEARQALNVLENPRDRAQVETTLRAIAAV 68 L +S+ AA A+ AA A +E A + + E R AA+ Sbjct: 192 LFTEAISSLQIRMNTLTAAKASIEAAAANKAREQAAA-------EAKRKAEEQARQQAAI 244 Query: 69 GALSAPAVPASAAPATSGASAAAAPAALTSNGLASML---VRQGSRWATQIGNALQESLR 125 A + A+PA+ + + A A + LA + + R + + Sbjct: 245 RAANTYAMPANGSVVATAAGRGLIQVAQGAASLAQAISDAIAVLGRVLASAPSVMAVGFA 304 Query: 126 SLLDIGSVGSWWHDKLVSADQRADLTRTLGILVAVLLPALIVEWLAKRLLRRALATV 182 SL W D+ + + A LG+ A L V A + +A TV Sbjct: 305 SLTYSSRTAEQWQDQTPDSVRYA-----LGMDAAKLGLPPSVNLNA---VAKASGTV 353
>PF05272#Virulence-associated E family protein Length = 892 Score = 30.8 bits (69), Expect = 0.011 Identities = 9/31 (29%), Positives = 15/31 (48%) Query: 37 LTLLGPSGSGKTTCLMMLAGFEFPTGGEIRL 67 + L G G GK+T + L G +F + + Sbjct: 599 VVLEGTGGIGKSTLINTLVGLDFFSDTHFDI 629
>PF06580#Sensor histidine kinase Length = 349 Score = 28.7 bits (64), Expect = 0.040 Identities = 17/109 (15%), Positives = 43/109 (39%), Gaps = 12/109 (11%) Query: 195 SIYLAIFGRTFVIGIAVTLFALLLGYPLAYWISTLSERRANLVMILVLIPFWTSVLVRVA 254 S+Y + + + IA++L L+L + +I + N+ I++ + + +V Sbjct: 32 SLYGSPKLHSMIFNIAISLMGLVLTHAYRSFIKRQGWLKLNMGQIILRV--LPACVVIGM 89 Query: 255 AWIV----------LLQSEGLINTALIGSGLISHPLTLLFNRVGVYISM 293 W V + ++ + T + +I + + + F +Y Sbjct: 90 VWFVANTSIWRLLAFINTKPVAFTLPLALSIIFNVVVVTFMWSLLYFGW 138
>ECOLNEIPORIN#E.coli/Neisseria porin superfamily signature. Length = 331 Score = 80.6 bits (199), Expect = 4e-19 Identities = 75/322 (23%), Positives = 119/322 (36%), Gaps = 31/322 (9%) Query: 20 AACLAAPAAHAQSSVTMYGIMDAGIEFTNHAAPQGGNSVKLKSGNKNT---SRWGLRGVE 76 A LAA A + VT+YG + AG+E + A G + +++G S+ G +G E Sbjct: 7 ALTLAALPVAAMADVTLYGTIKAGVETSRSVAHNGAQAASVETGTGIVDLGSKIGFKGQE 66 Query: 77 DLGGGLKAVFRLESGIDLANGASDDGPDSIFARRATVGLKGKWGELSLGRNFTVTYDY-- 134 DLG GLKA++++E +A S G R++ +GLKG +G+L +GR +V D Sbjct: 67 DLGNGLKAIWQVEQKASIAGTDSGWG-----NRQSFIGLKGGFGKLRVGRLNSVLKDTGD 121 Query: 135 MLPFDPMGYAQNYSWATSSMATGGRKDGLFTRSSNAVRYDG-EFSGFKFGALYGFGNVPG 193 + P+D + +A + +VRYD EF+G Y + G Sbjct: 122 INPWDSKS----DYLGVNKIA---EPEARLI----SVRYDSPEFAGLSGSVQYALNDNAG 170 Query: 194 SMKTSSKYDFAVGYETGPFAAVVTFDRQNGAADSVTPADTVNYIQGIHAGLSYDFGNLKT 253 S Y Y+ G F + V + Q YD L Sbjct: 171 R-HNSESYHAGFNYKNGGFFVQYGGAYKR--HHQVQENVNIEKYQIHRLVSGYDNDAL-Y 226 Query: 254 MAGYRNYRRTFHTTAANQLSDMYWLGGSYQF-----TPTFSLIAAVYHQNIKGGTDTDPT 308 + + + + + + TP S + D Sbjct: 227 ASVAVQQQDAKLVEENYSHNSQTEVAATLAYRFGNVTPRVSYAHGFKGSFDATNYNNDYD 286 Query: 309 LVSVRAQYALSKRTVLYAAGAF 330 V V A+Y SKRT + + Sbjct: 287 QVVVGAEYDFSKRTSALVSAGW 308
>FLGPRINGFLGI#Flagellar P-ring protein signature. Length = 373 Score = 28.0 bits (62), Expect = 0.035 Identities = 14/42 (33%), Positives = 21/42 (50%), Gaps = 1/42 (2%) Query: 71 IGVHQGLLKLAIFNVSGRGCTFS-GVPSGGWFGEGSVIKREL 111 V QG L + F+ G T + GV + G++I+REL Sbjct: 142 YAVAQGALIVNGFSAQGDAATLTQGVTTSARVPNGAIIEREL 183
>HTHFIS#FIS bacterial regulatory protein HTH signature. Length = 484 Score = 331 bits (850), Expect = e-113 Identities = 123/344 (35%), Positives = 171/344 (49%), Gaps = 32/344 (9%) Query: 26 ANRTKQRADGRRLSGRSAAMRTLLGRIEKIAPTRASVMIAGESGVGKDIVARRLHDLSAR 85 + DG L GRSAAM+ + + ++ T ++MI GESG GK++VAR LHD R Sbjct: 127 SKLEDDSQDGMPLVGRSAAMQEIYRVLARLMQTDLTLMITGESGTGKELVARALHDYGKR 186 Query: 86 RDGPFVPMNCGAIPAELAEAQLFGHEKGSFTGAITQREGFFEAARGGTLLLDEIAEMPAA 145 R+GPFV +N AIP +L E++LFGHEKG+FTGA T+ G FE A GGTL LDEI +MP Sbjct: 187 RNGPFVAINMAAIPRDLIESELFGHEKGAFTGAQTRSTGRFEQAEGGTLFLDEIGDMPMD 246 Query: 146 LQVKLLRAIESNTIVRVGGTEPIPIDVRFVSATRHNPAEAVRDGRLREDLFYRLAAFAIY 205 Q +LLR ++ VGG PI DVR V+AT + +++ G REDL+YRL + Sbjct: 247 AQTRLLRVLQQGEYTTVGGRTPIRSDVRIVAATNKDLKQSINQGLFREDLYYRLNVVPLR 306 Query: 206 VPPLRQRDGDVETIAQEFVDTLNARHRAHKRLTDAAIAALRTYSWPGNVRELHNTIERAY 265 +PPLR R D+ + + FV KR A+ ++ + WPGNVREL N + R Sbjct: 307 LPPLRDRAEDIPDLVRHFVQQAEKEGLDVKRFDQEALELMKAHPWPGNVRELENLVRRLT 366 Query: 266 ILADEG----------IDVALPKQALPAAESTSEGAM------------------ALPVG 297 L + + +P + A + S ALP Sbjct: 367 ALYPQDVITREIIENELRSEIPDSPIEKAAARSGSLSISQAVEENMRQYFASFGDALPPS 426 Query: 298 ATLHHAQQRF----IAETLRHFDGNKPRAAKALGISLKTLYNRL 337 I L GN+ +AA LG++ TL ++ Sbjct: 427 GLYDRVLAEMEYPLILAALTATRGNQIKAADLLGLNRNTLRKKI 470
>HTHFIS#FIS bacterial regulatory protein HTH signature. Length = 484 Score = 91.8 bits (228), Expect = 1e-21 Identities = 35/118 (29%), Positives = 53/118 (44%), Gaps = 3/118 (2%) Query: 527 LDGQRVLVVDDDATSRTSLAAALETMGAQVSTARSGHDALEAVERQPPSVVLSDLAMPDG 586 + G +LV DDDA RT L AL G V + + +V++D+ MPD Sbjct: 1 MTGATILVADDDAAIRTVLNQALSRAGYDVRITSNAATLWRWIAAGDGDLVVTDVVMPDE 60 Query: 587 DGYWLLDRIRRLPNGGGHLPVVAVTAHAGKADRRRVMAAGFDAYLCKPVDMPTLASVI 644 + + LL RI++ LPV+ ++A + G YL KP D+ L +I Sbjct: 61 NAFDLLPRIKKA---RPDLPVLVMSAQNTFMTAIKASEKGAYDYLPKPFDLTELIGII 115
>CHANLCOLICIN#Channel forming colicin signature. Length = 522 Score = 27.3 bits (60), Expect = 0.039 Identities = 12/45 (26%), Positives = 18/45 (40%), Gaps = 1/45 (2%) Query: 66 LEGVAIGAIVGLAGAALLYLGGLHSPLAWIGVPLVGGYVGALCGA 110 LE A A V ALL+ + L G+ +V G + + Sbjct: 467 LEKKAADAGVS-YVVALLFSLLAGTTLGIWGIAIVTGILCSYIDK 510
>PF05272#Virulence-associated E family protein Length = 892 Score = 29.7 bits (66), Expect = 0.005 Identities = 11/43 (25%), Positives = 14/43 (32%) Query: 109 DKGRWPAMADPAWAEALHAYYGSSPYWLIEEGETALDSPPYEA 151 + +AEALH Y Y+ E E P E Sbjct: 718 NLVWLQKFRGQLFAEALHLYLAGERYFPSPEDEEIYFRPEQEL 760
>TCRTETB#Tetracycline resistance protein TetB signature. Length = 458 Score = 31.0 bits (70), Expect = 0.009 Identities = 31/150 (20%), Positives = 58/150 (38%), Gaps = 3/150 (2%) Query: 8 MILMCFLANVINFIDRANLAIAAPSIRADLGLDAVGMGLVLSAFFWTYAFLQLPAGWFID 67 +I +C L+ + ++ L ++ P I D V +AF T++ G D Sbjct: 16 LIWLCILS-FFSVLNEMVLNVSLPDIANDFNKPPASTNWVNTAFMLTFSIGTAVYGKLSD 74 Query: 68 KVGVRVSLALAVGWWSVFTVATGAARGLAQ-LVGVRLMLGVGEAAAIPSFAKVAFNWFPR 126 ++G++ L + +V L+ R + G G AA V + P+ Sbjct: 75 QLGIKRLLLFGIIINCFGSVIGFVGHSFFSLLIMARFIQGAGAAAFPALVMVVVARYIPK 134 Query: 127 SERGLASSIFDSGSRVGSALSLPLVAWLIS 156 RG A + S +G + P + +I+ Sbjct: 135 ENRGKAFGLIGSIVAMGEGVG-PAIGGMIA 163
>PF06057#Type IV secretory pathway VirJ component Length = 243 Score = 307 bits (789), Expect = e-106 Identities = 73/211 (34%), Positives = 104/211 (49%), Gaps = 3/211 (1%) Query: 215 ELDVSDLPLVELPAKGGSDRLAIVISGDGGWRDLDKTIAEALQRDGVSVVGIDSLRYFWS 274 L V V + L I +SGDGGW LDK + LQ+ G VVG SL+Y+W Sbjct: 33 LLPVEPSTQVNAASSHTKPPLVIFLSGDGGWATLDKAVGGILQQQGWPVVGWSSLKYYWK 92 Query: 275 EKPPAQVSRDLARVMRTYMARWHASRVALVGYSFGADVMPFAYNRLPADLRDKVAVMSLL 334 +K P V++D ++ Y A + +V L+GYSFGA+V+PF N +PA R V LL Sbjct: 93 QKDPKDVTQDTLAIIDKYQAEFGTQKVILIGYSFGAEVIPFVLNEMPARYRKNVLGAVLL 152 Query: 335 GFAPSADFQIRVTGWLGMPASDKALKVAPEIAKVPPTLVQCFYGAEETDT--MCPALANT 392 + S+DF+I V+ + PE+ K + C YG E+ +CP + Sbjct: 153 SPSQSSDFEIHVSEMVTSDNQSARYLTLPEVNKQTTVPMLCLYGKEDDAPLHLCPEVKQP 212 Query: 393 GADVIKTQGDHHFGRDYIALEKKILGGFGKP 423 V++ G H F DY + K I G+ KP Sbjct: 213 NVTVMELSGGHSFDDDYDKVVKLIK-GWLKP 242 Score = 38.7 bits (90), Expect = 3e-05 Identities = 17/76 (22%), Positives = 25/76 (32%) Query: 17 MMLAGAACAAQPADVKAETVSGGRYGPVTVTKPSGPLRGFVVLFSREAGWHVADQQAADA 76 + A A + AD T+ S V+ S + GW D+ Sbjct: 14 LCSTANAFADEFADNLGLTLLPVEPSTQVNAASSHTKPPLVIFLSGDGGWATLDKAVGGI 73 Query: 77 LAKAGAMTVGVDSGRY 92 L + G VG S +Y Sbjct: 74 LQQQGWPVVGWSSLKY 89
>PF06580#Sensor histidine kinase Length = 349 Score = 32.9 bits (75), Expect = 0.006 Identities = 26/154 (16%), Positives = 46/154 (29%), Gaps = 16/154 (10%) Query: 438 WWMTFA----LTLASLALSLAKG---LAFVEAGVLGTLLVLLLVSRRRFNRHSSLLAERF 490 W+ TL + G L + + +L+ L+L R +R Sbjct: 13 WYCQGIGWGVYTLTGFGFASLYGSPKLHSMIFNIAISLMGLVLTHAYRS------FIKRQ 66 Query: 491 TVSWFVSVAMVLMLAVWVLFFAFRDVPYTRDLWSHFSFDARAPRALRATLAAGVF---VA 547 ++L + + +W +F P A LA + V Sbjct: 67 GWLKLNMGQIILRVLPACVVIGMVWFVANTSIWRLLAFINTKPVAFTLPLALSIIFNVVV 126 Query: 548 LFALWQLLRPAPGRFVKPAQQDLIDAEQIIRAQE 581 + +W LL F Q ++ + AQE Sbjct: 127 VTFMWSLLYFGWHFFKNYKQAEIDQWKMASMAQE 160
>FLGLRINGFLGH#Flagellar L-ring protein signature. Length = 232 Score = 26.9 bits (59), Expect = 0.030 Identities = 14/40 (35%), Positives = 19/40 (47%), Gaps = 1/40 (2%) Query: 7 FPIRTLLIATALGAVAIGSAPAV-GQTSTSTVPAGSAAAT 45 + I +LL+ + G I S P V G TS VP + A Sbjct: 9 YAISSLLVLSLTGCAWIPSTPLVQGATSAQPVPGPTPVAN 48
>DHBDHDRGNASE#2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase signature. Length = 261 Score = 95.9 bits (238), Expect = 8e-26 Identities = 52/184 (28%), Positives = 77/184 (41%), Gaps = 6/184 (3%) Query: 4 KRILITGAGTGFGREVALRLAERGHDVTAGVRTAVEIDALTDAAAQRGTALRAVKLDVTS 63 K ITGA G G VA LA +G + A +++ + + A DV Sbjct: 9 KIAFITGAAQGIGEAVARTLASQGAHIAAVDYNPEKLEKVVSSLKAEARHAEAFPADVRD 68 Query: 64 A------YDRARAAELDVDVLVNNAGVGEAGALVDLPVEIVRELFDVNVFGPLELTQQIA 117 + R +D+LVN AGV G + L E F VN G ++ ++ Sbjct: 69 SAAIDEITARIEREMGPIDILVNVAGVLRPGLIHSLSDEEWEATFSVNSTGVFNASRSVS 128 Query: 118 RGMLARKHGKIVFVSSIAGLITGPFTGAYCASKHAIESVAEAMHAELAPHGIRVAVVNPG 177 + M+ R+ G IV V S + AY +SK A + + ELA + IR +V+PG Sbjct: 129 KYMMDRRSGSIVTVGSNPAGVPRTSMAAYASSKAAAVMFTKCLGLELAEYNIRCNIVSPG 188 Query: 178 PYRT 181 T Sbjct: 189 STET 192
>SECBCHAPRONE#Bacterial protein-transport SecB chaperone protein signature. Length = 170 Score = 28.7 bits (64), Expect = 0.004 Identities = 10/56 (17%), Positives = 18/56 (32%), Gaps = 4/56 (7%) Query: 10 TRVCPLDD----IVPNTGVCALVNGEQVAVFHVAHADGGVFAIDNVDPVSQAAVMS 61 T + D + N V + F GVF I ++ + A ++ Sbjct: 55 TEAKQVGDDLYEVCLNISVETTMESSGDVAFICEVKQAGVFTISGLEEMQMAHCLT 110
>DHBDHDRGNASE#2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase signature. Length = 261 Score = 97.8 bits (243), Expect = 1e-26 Identities = 62/196 (31%), Positives = 95/196 (48%), Gaps = 3/196 (1%) Query: 3 VSKKFAAVTGAGSGIGRAAAIALARAGFTVALLGRTEASLSETQNAIRAAGGDAQVFPVD 62 + K A +TGA GIG A A LA G +A + L + ++++A A+ FP D Sbjct: 6 IEGKIAFITGAAQGIGEAVARTLASQGAHIAAVDYNPEKLEKVVSSLKAEARHAEAFPAD 65 Query: 63 VTDEASVDHAFAQIAQRFGRLDVLFNNAGRNAPVVALDEYELDVWNSVVATNLTGVFLCA 122 V D A++D A+I + G +D+L N AG P + + W + + N TGVF + Sbjct: 66 VRDSAAIDEITARIEREMGPIDILVNVAGVLRP-GLIHSLSDEEWEATFSVNSTGVFNAS 124 Query: 123 RAAWRLMKTQTPQGGRIINNGSISAHAPRPDTIAYTATKHAVTGITKSLALDGRRYNIAC 182 R+ + M + + G I+ GS A PR AY ++K A TK L L+ YNI C Sbjct: 125 RSVSKYMMDR--RSGSIVTVGSNPAGVPRTSMAAYASSKAAAVMFTKCLGLELAEYNIRC 182 Query: 183 GQIDIGNAATALTERM 198 + G+ T + + Sbjct: 183 NIVSPGSTETDMQWSL 198
>HTHFIS#FIS bacterial regulatory protein HTH signature. Length = 484 Score = 83.7 bits (207), Expect = 6e-21 Identities = 39/139 (28%), Positives = 59/139 (42%), Gaps = 2/139 (1%) Query: 2 AHILTIEDDPLIADHIAHTLRAAGHQIDIARTGRDGMARAMSANYDVVTLDRMLPDLDGL 61 A IL +DD I + L AG+ + I + + D+V D ++PD + Sbjct: 4 ATILVADDDAAIRTVLNQALSRAGYDVRITSNAATLWRWIAAGDGDLVVTDVVMPDENAF 63 Query: 62 TILATMRGVGLDTPVLVMSAMSGVDQRIEGLRAGGDDYLVKPFSLEEMCARIDVLIRRRP 121 +L ++ D PVLVMSA + I+ G DYL KPF L E+ I + Sbjct: 64 DLLPRIKKARPDLPVLVMSAQNTFMTAIKASEKGAYDYLPKPFDLTELIGIIGRALAEPK 123 Query: 122 RGARVETVLRAGELALDLV 140 R R + + + LV Sbjct: 124 R--RPSKLEDDSQDGMPLV 140
>ACRIFLAVINRP#Acriflavin resistance protein family signature. Length = 1034 Score = 641 bits (1655), Expect = 0.0 Identities = 247/1079 (22%), Positives = 435/1079 (40%), Gaps = 68/1079 (6%) Query: 4 IVRLALTRPYTFVVLALLILIAGPLAAVRTPIDIFPDIRIPVISVVWNYAGLQPDDMSGR 63 + + RP VLA+++++AG LA ++ P+ +P I P +SV NY G + Sbjct: 1 MANFFIRRPIFAWVLAIILMMAGALAILQLPVAQYPTIAPPAVSVSANYPGADAQTVQDT 60 Query: 64 VITYYERTLGTTVNDVQHIESQSFR-GYGIVKIFFQPTVDIRTATAQVTSISQTVLKQMP 122 V E+ + ++++ ++ S S G + + FQ D A QV + Q +P Sbjct: 61 VTQVIEQNM-NGIDNLMYMSSTSDSAGSVTITLTFQSGTDPDIAQVQVQNKLQLATPLLP 119 Query: 123 PGTTPPQILNYNASTVPVLQIALTSNTLDEQK--LGDYAVNFIRPQLLSVPGVAIPTPYG 180 I +S+ ++ S+ + + DY + ++ L + GV +G Sbjct: 120 QEVQQQGISVEKSSSSYLMVAGFVSDNPGTTQDDISDYVASNVKDTLSRLNGVGDVQLFG 179 Query: 181 GKTREVQIDLDPQALQSKGLSAQDVAHALAQQNQIIPAGT------QKIGRFEYNIKLNN 234 + ++I LD L L+ DV + L QN I AG + +I Sbjct: 180 AQ-YAMRIWLDADLLNKYKLTPVDVINQLKVQNDQIAAGQLGGTPALPGQQLNASIIAQT 238 Query: 235 SPLSLDALNDLPIKSVG-GTTIYIRDVAHVRDGYPPQGNIVRVDGHRAVLMSILKNGSAS 293 + + + ++ G+ + ++DVA V G I R++G A + I A+ Sbjct: 239 RFKNPEEFGKVTLRVNSDGSVVRLKDVARVELGGENYNVIARINGKPAAGLGIKLATGAN 298 Query: 294 TLDIIAGVKAKLPLVEQTLPPGLKLVTMGDQSTFVNGAVSGVAREGIIAAALTSLMILLF 353 LD +KAKL ++ P G+K++ D + FV ++ V + A L L++ LF Sbjct: 299 ALDTAKAIKAKLAELQPFFPQGMKVLYPYDTTPFVQLSIHEVVKTLFEAIMLVFLVMYLF 358 Query: 354 LGSWRSTLIIAASIPLAVLSAIALLAATGETLNVMTLGGLALAVGILVDDATVTIENV-N 412 L + R+TLI ++P+ +L A+LAA G ++N +T+ G+ LA+G+LVDDA V +ENV Sbjct: 359 LQNMRATLIPTIAVPVVLLGTFAILAAFGYSINTLTMFGMVLAIGLLVDDAIVVVENVER 418 Query: 413 WHLEQGKDTRTAIVDGAKQIVMPALVSLLCICIVFVPMLMLDGISRFLFVPMAKAVIFSM 472 +E + A QI + + + VF+PM G + ++ + ++ +M Sbjct: 419 VMMEDKLPPKEATEKSMSQIQGALVGIAMVLSAVFIPMAFFGGSTGAIYRQFSITIVSAM 478 Query: 473 VSSFVLSRTFVPMLAQYLLKPHASAGHASGELAAVMDPHAGHAGAHDVPPSRNPLVRFQR 532 S +++ P L LLKP ++ H F Sbjct: 479 ALSVLVALILTPALCATLLKPVSAEHH-------------------------ENKGGFFG 513 Query: 533 AFERRFESVRASYRILLGLALTRRKPFVVAFLCIVAASFLLAPSLGRNFFPTIDSGEIAL 592 F F+ Y +G L +++ + IVA +L L +F P D G Sbjct: 514 WFNTTFDHSVNHYTNSVGKILGSTGRYLLIYALIVAGMVVLFLRLPSSFLPEEDQGVFLT 573 Query: 593 HVRAPVGTRVEETAAELDRIENTIRGVIPPAQLREVIDNIGLPNSGINLTYNNSGTLGPQ 652 ++ P G E T LD++ + L+ N+ + +++ Sbjct: 574 MIQLPAGATQERTQKVLDQVTDYY--------LKNEKANVESVFTVNGFSFSGQ---AQN 622 Query: 653 DGDILISL-----SRDHAPTADYV-HTLRERLPRAYPGTTFSFLPADIVSQILNFGAPAP 706 G +SL +A+ V H + L + G F IV L Sbjct: 623 AGMAFVSLKPWEERNGDENSAEAVIHRAKMELGKIRDGFVIPFNMPAIVE--LGTATGFD 680 Query: 707 VDLQVAGPNQQANLAYAHELYRKLR--LIAGVADPRIQQASTYPQFTVTVDRTRADQLGI 764 +L L A + A + R QF + VD+ +A LG+ Sbjct: 681 FELIDQAGLGHDALTQARNQLLGMAAQHPASLVSVRPNGLEDTAQFKLEVDQEKAQALGV 740 Query: 765 TEQDVTNSVVATLAGTSQVDPTYWLNPRNGVSYPIVAQTPQYRMTTLSALQNLPVTGANG 824 + D+ ++ L GT D G + Q + L V ANG Sbjct: 741 SLSDINQTISTALGGTYVNDFI-----DRGRVKKLYVQADAKFRMLPEDVDKLYVRSANG 795 Query: 825 QSQLLGGLATITRGVGNAVVSHYNIEPLFDIYATTQGRDLGAVATDIDDVVKATAKDLPK 884 + T G+ + YN P +I G + D +++ A LP Sbjct: 796 EMVPFSAFTTSHWVYGSPRLERYNGLPSMEIQGEAAP---GTSSGDAMALMENLASKLPA 852 Query: 885 GSTVTLRGQVQTMNGAFAGLLLGLVGAIVLIYLLIVVNFHSWADAFVIVSALPAALAGIV 944 G G + + + V+++L + + SW+ ++ +P + G++ Sbjct: 853 GIGYDWTGMSYQERLSGNQAPALVAISFVVVFLCLAALYESWSIPVSVMLVVPLGIVGVL 912 Query: 945 WMLFTTHTPLSVPALTGAILCMGVATANSILVVSFARERLAETGNALASA-LEAGFTRFR 1003 + V + G + +G++ N+IL+V FA++ + + G + A L A R R Sbjct: 913 LAATLFNQKNDVYFMVGLLTTIGLSAKNAILIVEFAKDLMEKEGKGVVEATLMAVRMRLR 972 Query: 1004 PVLMTALAMIIGMAPMALGLGDGGEQNAPLGRAVIGGLACATIATLFFVPVVFSLVHRR 1062 P+LMT+LA I+G+ P+A+ G G +G V+GG+ AT+ +FFVPV F ++ R Sbjct: 973 PILMTSLAFILGVLPLAISNGAGSGAQNAVGIGVMGGMVSATLLAIFFVPVFFVVIRRC 1031 Score = 92.6 bits (230), Expect = 5e-21 Identities = 93/535 (17%), Positives = 189/535 (35%), Gaps = 50/535 (9%) Query: 550 GLALTRRKPFVVAFLCIVAASFLLAPSLGRNFFPTIDSGEIALHVRAPVGTRVEETAAEL 609 + R V + ++ A L L +PTI +++ P G + + Sbjct: 3 NFFIRRPIFAWVLAIILMMAGALAILQLPVAQYPTIAPPAVSVSANYP-GADAQTVQDTV 61 Query: 610 DR-IENTIRGVIPPAQLREVIDNIGLPNSGINLTYNNSGTLGPQDGDILISLSRDHAPTA 668 + IE + G+ + D+ G I LT+ D I+ + Sbjct: 62 TQVIEQNMNGIDNLMYMSSTSDSAGS--VTITLTFQ-------SGTDPDIAQVQ------ 106 Query: 669 DYVHTLRERLPRAYPGTTFSFLPADIVSQILNFGAPAPVDLQV------AGPNQQANLAY 722 ++ +L A P LP ++ Q ++ + L V Q +++ Sbjct: 107 -----VQNKLQLATP-----LLPQEVQQQGISVEKSSSSYLMVAGFVSDNPGTTQDDISD 156 Query: 723 --AHELYRKLRLIAGVADPRIQQASTYPQFTVTVDRTRADQLGITEQDVTNSVVATLA-- 778 A + L + GV D +Q + +D ++ +T DV N + Sbjct: 157 YVASNVKDTLSRLNGVGD--VQLFGAQYAMRIWLDADLLNKYKLTPVDVINQLKVQNDQI 214 Query: 779 GTSQVDPTYWLNPRNGVSYPIVAQTPQYRMTTLSALQNLPV-TGANGQSQLLGGLATITR 837 Q+ T L P ++ I+AQT R + + ++G L +A + Sbjct: 215 AAGQLGGTPAL-PGQQLNASIIAQT---RFKNPEEFGKVTLRVNSDGSVVRLKDVARVEL 270 Query: 838 GVGN-AVVSHYNIEP--LFDIYATTQGRDLGAVATDIDDVVKATAKDLPKG-STVTLRGQ 893 G N V++ N +P I T L A I + P+G + Sbjct: 271 GGENYNVIARINGKPAAGLGIKLATGANAL-DTAKAIKAKLAELQPFFPQGMKVLYPYDT 329 Query: 894 VQTMNGAFAGLLLGLVGAIVLIYLLIVVNFHSWADAFVIVSALPAALAGIVWMLFTTHTP 953 + + ++ L AI+L++L++ + + + A+P L G +L Sbjct: 330 TPFVQLSIHEVVKTLFEAIMLVFLVMYLFLQNMRATLIPTIAVPVVLLGTFAILAAFGYS 389 Query: 954 LSVPALTGAILCMGVATANSILVVSFARERLAETGNALASALEAGFTRFRPVLMTALAMI 1013 ++ + G +L +G+ ++I+VV + E A E ++ + L+ ++ Sbjct: 390 INTLTMFGMVLAIGLLVDDAIVVVENVERVMMEDKLPPKEATEKSMSQIQGALVGIAMVL 449 Query: 1014 IGM-APMALGLGDGGEQNAPLGRAVIGGLACATIATLFFVPVVFSLVHRRDALKH 1067 + PMA G G ++ +A + + L P + + + + + +H Sbjct: 450 SAVFIPMAFFGGSTGAIYRQFSITIVSAMALSVLVALILTPALCATLLKPVSAEH 504
>RTXTOXIND#Gram-negative bacterial RTX secretion protein D signature. Length = 478 Score = 34.8 bits (80), Expect = 5e-04 Identities = 24/148 (16%), Positives = 49/148 (33%), Gaps = 13/148 (8%) Query: 117 ELDQQLQQARADLQSSLANEKLAASTAARWTRMLAQDSVSQQETDEKTSDLAAKQAIVAA 176 E +L+ ++ L + +E L+A + L ++ + + ++ +A Sbjct: 263 EAVNELRVYKSQL-EQIESEILSAKEEYQLVTQLFKNEILDKLRQTT-DNIGLLTLELAK 320 Query: 177 NEANVRRLDALEAFKRIVAPFDGVVTARKT-DIGQLISAGGGAGPELFAVSDVHRMRVYV 235 NE + I AP V K G +++ + V + + V Sbjct: 321 NEERQQASV-------IRAPVSVKVQQLKVHTEGGVVTTA---ETLMVIVPEDDTLEVTA 370 Query: 236 SVPQNEAAAIRPGMTATLTVPEHPGETF 263 V + I G A + V P + Sbjct: 371 LVQNKDIGFINVGQNAIIKVEAFPYTRY 398 Score = 34.0 bits (78), Expect = 9e-04 Identities = 18/104 (17%), Positives = 32/104 (30%), Gaps = 13/104 (12%) Query: 85 IHAQVSGYLHAWYTDIGAHVKSGQLLGLIDTPELDQQLQQARADLQSSLANEKLAASTAA 144 I + + G V+ G +L + A AD + ++ A Sbjct: 99 IKPIENSIVKEIIVKEGESVRKGDVLLKLTAL-------GAEADTLKTQSSLLQARLEQT 151 Query: 145 RWTRMLAQDSVSQQETDEKT-SDLAAKQAIVAANEANVRRLDAL 187 R+ Q E ++ L + +E V RL +L Sbjct: 152 RY-----QILSRSIELNKLPELKLPDEPYFQNVSEEEVLRLTSL 190
>ECOLNEIPORIN#E.coli/Neisseria porin superfamily signature. Length = 331 Score = 105 bits (264), Expect = 1e-27 Identities = 76/395 (19%), Positives = 137/395 (34%), Gaps = 68/395 (17%) Query: 19 MKKYLAIPAAVACLLASAAHAQSSVTLYGTIDAGLDYISNQKSAAGAGPVYGVQSGNVST 78 MKK L I +A L +A + VTLYGTI AG++ + +G V Sbjct: 1 MKKSL-IALTLAALPVAAM---ADVTLYGTIKAGVETSRSVAHNGAQAASVETGTGIVDL 56 Query: 79 -SRWGLRGNEDLGGGLAAVFTLENGFNVANGKLGNGGDEFGRQAWVGLASRQWGTVTLGR 137 S+ G +G EDLG GL A++ +E ++A G RQ+++GL +G + +GR Sbjct: 57 GSKIGFKGQEDLGNGLKAIWQVEQKASIA----GTDSGWGNRQSFIGLKG-GFGKLRVGR 111 Query: 138 QYDFLVDF--VAPLSATGSGFGGNLVDHPYDNDNLANDTRMNNAVKFRSANYGGFTFGGA 195 L D + P + G N + P + R+ + ++ S + G + Sbjct: 112 LNSVLKDTGDINPWDSKSDYLGVNKIAEP--------EARLISV-RYDSPEFAGLSGSVQ 162 Query: 196 YGFSNQGGGFSNDNAYSVGAQYVNGPVDLAVAYLQSNQPGGVDAPQNTGGSLSSADGDAM 255 Y ++ G N +Y G Y NG + Sbjct: 163 YALND-NAGRHNSESYHAGFNYKNGGFFVQYGGAYKR----------------HHQVQEN 205 Query: 256 LTGGRWRTFGAGAHYAFDHAAI-GFVYTRTILNDPRELSQGGAYGRVNGQLLTFSNYELN 314 + +++ + Y D+ A+ V + + + ++ T + N Sbjct: 206 VNIEKYQIHRLVSGY--DNDALYASVAVQQQDAKL--VEENYSHNSQTEVAATLAYRFGN 261 Query: 315 GRYFLTPALSLGGAYTFTQGRFDDAGRGIAPKWNQFMLQADYALSRRTDLYLEGVYQRVT 374 ++ A G++ ++Q ++ A+Y S+RT + + + Sbjct: 262 VTPRVSYAHGFKGSFD---------ATNYNNDYDQVVVGAEYDFSKRTSALVSAGWLQ-- 310 Query: 375 GADGVAVLGHAGIFNLAASGNDRQAVVAAGIRHKF 409 G G+RHKF Sbjct: 311 EGKG--------------ESKFVSTAGGVGLRHKF 331
>HTHFIS#FIS bacterial regulatory protein HTH signature. Length = 484 Score = 74.1 bits (182), Expect = 1e-15 Identities = 33/120 (27%), Positives = 57/120 (47%), Gaps = 1/120 (0%) Query: 931 RRTILVVDDLDDQRDIVVQLLTPLGFDVAEAASGTDALRWLAMHTADAIIMDISMPLMDG 990 TILV DD R ++ Q L+ G+DV ++ RW+A D ++ D+ MP + Sbjct: 3 GATILVADDDAAIRTVLNQALSRAGYDVRITSNAATLWRWIAAGDGDLVVTDVVMPDENA 62 Query: 991 YETSRLISENQLSNAPIVLLSANAFADDRDRASATGCKGYLVKPLQVNLLLDKLAQLLAL 1050 ++ I + + P++++SA +AS G YL KP + L+ + + LA Sbjct: 63 FDLLPRIKK-ARPDLPVLVMSAQNTFMTAIKASEKGAYDYLPKPFDLTELIGIIGRALAE 121
>HTHFIS#FIS bacterial regulatory protein HTH signature. Length = 484 Score = 89.5 bits (222), Expect = 4e-22 Identities = 34/125 (27%), Positives = 54/125 (43%), Gaps = 2/125 (1%) Query: 2 ILIVDDTPENLAFLSDTLQAHGYVVIVALSGEDALKRLARVTPDVVLLDAMMPDMDGFET 61 IL+ DD L+ L GY V + + + +A D+V+ D +MPD + F+ Sbjct: 6 ILVADDDAAIRTVLNQALSRAGYDVRITSNAATLWRWIAAGDGDLVVTDVVMPDENAFDL 65 Query: 62 CVRIKQDGRHEHLPVIFMTALTESEHVVRGFRVGGIDYVTKPVQPEELCARIGAHVRRSR 121 RIK+ LPV+ M+A ++ G DY+ KP EL IG + + Sbjct: 66 LPRIKK--ARPDLPVLVMSAQNTFMTAIKASEKGAYDYLPKPFDLTELIGIIGRALAEPK 123 Query: 122 AQLYA 126 + Sbjct: 124 RRPSK 128
>TCRTETA#Tetracycline resistance protein signature. Length = 399 Score = 42.9 bits (101), Expect = 2e-06 Identities = 36/133 (27%), Positives = 58/133 (43%), Gaps = 8/133 (6%) Query: 42 GIISGALPLIARDFGLDYRAQE----LVAAAILLGAVIGALAGTRMSAAFGRRKTITIVS 97 G+I LP + RD L+A L+ + G +S FGRR + + Sbjct: 22 GLIMPVLPGLLRDLVHSNDVTAHYGILLALYALMQFACAPVLG-ALSDRFGRRPVLLVSL 80 Query: 98 AIYAAGVLAAALSPDAWSLAASRLVLGFAVGGSTQIVPT-YIAELAEPDKRGRLVTYFNV 156 A A A +P W L R+V G + G+T V YIA++ + D+R R + + Sbjct: 81 AGAAVDYAIMATAPFLWVLYIGRIVAG--ITGATGAVAGAYIADITDGDERARHFGFMSA 138 Query: 157 SIGIGILLAALIG 169 G G++ ++G Sbjct: 139 CFGFGMVAGPVLG 151
>PREPILNPTASE#Type IV prepilin cysteine protease (C20) family signature. Length = 290 Score = 29.8 bits (67), Expect = 0.031 Identities = 14/46 (30%), Positives = 19/46 (41%) Query: 48 ARAALASLLAGALGIASALHLGFAITTGAVGILFSMIAPLFLRDAH 93 AR L LL L +A A+ L T A +L ++ L D Sbjct: 108 ARYPLVELLTALLSVAVAMTLAPGWGTLAALLLTWVLVALTFIDLD 153
>SECA#SecA protein signature. Length = 901 Score = 29.8 bits (67), Expect = 0.020 Identities = 16/54 (29%), Positives = 25/54 (46%), Gaps = 1/54 (1%) Query: 193 TRAAPGGTGDAKCGGNYAASLAAQAEAIREGCEQVVFLDAVERRWIEELGGMNV 246 T A GT D GG++ A +AA E E++ V + E GG+++ Sbjct: 504 TNMAGRGT-DIVLGGSWQAEVAALENPTAEQIEKIKADWQVRHDAVLEAGGLHI 556
>RTXTOXIND#Gram-negative bacterial RTX secretion protein D signature. Length = 478 Score = 74.9 bits (184), Expect = 5e-17 Identities = 58/423 (13%), Positives = 121/423 (28%), Gaps = 102/423 (24%) Query: 8 RPSVKGRVIALAIVALGIAALAYAY--HRTTAYPSTDDASIDADVVHVASPVGGRIVQLA 65 S + R++A I+ + A + + + + + ++ Sbjct: 52 PVSRRPRLVAYFIMGFLVIAFILSVLGQVEIVATANGKLTHSGRSKEIKPIENSIVKEII 111 Query: 66 VHENQRVAKGDLLYVIDPVPYRLTVAQAQADLELAR-------ASLDTRRR------SLI 112 V E + V KGD+L + + + Q+ L AR + L Sbjct: 112 VKEGESVRKGDVLLKLTALGAEADTLKTQSSLLQARLEQTRYQILSRSIELNKLPELKLP 171 Query: 113 GERSNASVAAEQVKRATQNY-------------------------DLATRDVNRL----- 142 E +V+ E+V R T +NR Sbjct: 172 DEPYFQNVSEEEVLRLTSLIKEQFSTWQNQKYQKELNLDKKRAERLTVLARINRYENLSR 231 Query: 143 ---------APLAAQGYVSAQQF----------------DQAKVRQRDASVSLAQAQEQQ 177 + L + ++ ++++ Q ++ + A+ + Q Sbjct: 232 VEKSRLDDFSSLLHKQAIAKHAVLEQENKYVEAVNELRVYKSQLEQIESEILSAKEEYQL 291 Query: 178 RAS---AQTIGDDADAIATLHAREAALARAQHALDDTVVRAPHDGLVTGLSVL-PGETLA 233 + + + LA+ + +V+RAP V L V G + Sbjct: 292 VTQLFKNEILDKLRQTTDNIGLLTLELAKNEERQQASVIRAPVSVKVQQLKVHTEGGVVT 351 Query: 234 PNQSIFTLIDASEWFAV-GNFRETSLNRIAVGDCATV-YSMIDRSR--PLTGKVVGIGAG 289 +++ ++ + V + + I VG A + +R L GKV I Sbjct: 352 TAETLMVIVPEDDTLEVTALVQNKDIGFINVGQNAIIKVEAFPYTRYGYLVGKVKNINLD 411 Query: 290 IADSARINLPRSLPIVQNSVNWVHVAQRFPVRVKLDEP------DGKLVRVGASAIVEVR 343 + R+ L F V + ++E + G + E++ Sbjct: 412 AIEDQRLGLV------------------FNVIISIEENCLSTGNKNIPLSSGMAVTAEIK 453 Query: 344 HGS 346 G Sbjct: 454 TGM 456
>adhesinmafb#Neisseria meningitidis: adhesin MafB signature. Length = 467 Score = 30.4 bits (68), Expect = 0.027 Identities = 27/108 (25%), Positives = 34/108 (31%), Gaps = 13/108 (12%) Query: 281 AILERGGYPVDVTLALPPADALPPLARIAATDLQDAITHFAEPGATA--------PTVDA 332 IL Y +D A+ LP + A ++ F + A P Sbjct: 250 DILYGTRYAIDKA-AMRNIAPLPAEGKFAVIGGLGSVAGFEKNTREAVDRWIQENPNAAE 308 Query: 333 TAEASANATPAAAAATPEAPAAAPAPAPHGGFFLPDARTN---PDHIR 377 T EA N AA A A AA P A G F + D R Sbjct: 309 TVEAVFNVAAAAKVAK-LAKAAKPGKAAVSGDFADSYKKKLALSDSAR 355
>CHANLCOLICIN#Channel forming colicin signature. Length = 522 Score = 31.6 bits (71), Expect = 0.009 Identities = 27/101 (26%), Positives = 43/101 (42%), Gaps = 1/101 (0%) Query: 402 SAVLMQARNDAESASARLTRTKEEAVRQVVAAQNAVQTSLASHDAAKALVDAAQTSYDAA 461 + +A +AE + R K E RQ+ A+ + A + AKA V+ AQ AA Sbjct: 143 AEAAEKAFQEAEQRRKEIEREKAETERQLKLAEAEEKRLAALSEEAKA-VEIAQKKLSAA 201 Query: 462 LTAYRNGVGSVTDATIAQSQLLAARNAEVDSYAGALSAAAA 502 + G + S + AR+AE+ + AG + A Sbjct: 202 QSEVVKMDGEIKTLNSRLSSSIHARDAEMKTLAGKRNELAQ 242
>AUTOINDCRSYN#Autoinducer synthesis protein signature. Length = 216 Score = 132 bits (333), Expect = 6e-41 Identities = 30/155 (19%), Positives = 61/155 (39%), Gaps = 10/155 (6%) Query: 11 LPHELAADLGRYRRRVFVEQLGWALPSANESFERDQFDRDDTVYVFARNADGDMCGCARL 70 L + +L R+ F ++L WA+ + E DQ+D ++T Y+F D + R Sbjct: 12 LSETKSGELFTLRKETFKDRLNWAVQCTD-GMEFDQYDNNNTTYLFGIK-DNTVICSLRF 69 Query: 71 LPTTRPYLLKSLFADLVAEDMPLPQSAAVWELSRFAATDDEGGSGNAEWAVRP----MLA 126 + T P ++ F ++ +P+ E SRF D+ + + P + Sbjct: 70 IETKYPNMITGTFFPYFK-EINIPEG-NYLESSRFFV--DKSRAKDILGNEYPISSMLFL 125 Query: 127 AVVECAAQLGARQLIGVTFASMERLFRRIGIHAHR 161 +++ + G + + M + +R G Sbjct: 126 SMINYSKDKGYDGIYTIVSHPMLTILKRSGWGIRV 160
>ISCHRISMTASE#Isochorismatase signature. Length = 312 Score = 60.8 bits (147), Expect = 3e-13 Identities = 49/219 (22%), Positives = 74/219 (33%), Gaps = 25/219 (11%) Query: 1 MCQPREHAMQHPTIRTLAGASAPTSIAAARTALLVIDFQNEYFSGRLP--IPDGPRALGN 58 M P Q PT + R LL+ D Q YF N Sbjct: 1 MAIPAIQPYQMPTASDMPQNKVSWVPDPNRAVLLIHDMQ-NYFVDAFTAGASPVTELSAN 59 Query: 59 ARRVIAFADRAGIPVFHVQHVGT---ADSPIFAD----GSDGFRFH----SDLQPAPHHA 107 R++ + GIPV + G+ D + D G + + ++L P Sbjct: 60 IRKLKNQCVQLGIPVVYTAQPGSQNPDDRALLTDFWGPGLNSGPYEEKIITELAPEDDDL 119 Query: 108 VVKKTSVSVFPTTDLDARLKAAGIDTLIVTGLMTHACVAGAARDAVPLGYAVIVVDDACA 167 V+ K S F T+L ++ G D LI+TG+ H A +A V DA Sbjct: 120 VLTKWRYSAFKRTNLLEMMRKEGRDQLIITGIYAHIGCLVTACEAFMEDIKAFFVGDA-- 177 Query: 168 TRDLDVADGGTVPHRDLHRATLAALSDTFGDVLTTEQVL 206 VAD + H+ L + + T+ +L Sbjct: 178 -----VADFS----LEKHQMALEYAAGRCAFTVMTDSLL 207
>TCRTETA#Tetracycline resistance protein signature. Length = 399 Score = 118 bits (298), Expect = 1e-31 Identities = 92/360 (25%), Positives = 153/360 (42%), Gaps = 23/360 (6%) Query: 42 LLAIALDAMGFGLVYPMMSAIFSDPHAGILPADAGVHARNFYLGLGYGIYPLCMFFGSSL 101 L +ALDA+G GL+ P++ + D D H G+ +Y L F + + Sbjct: 11 LSTVALDAVGIGLIMPVLPGLLRDLV---HSNDVTAH-----YGILLALYALMQFACAPV 62 Query: 102 MGELSDRYGRRRVLLLCVLGLAAGYAMMAAGAWHASVALLLAGRGLTGLMAGCQGIAQAA 161 +G LSDR+GRR VLL+ + G A YA+MA + +L GR + G+ +A A Sbjct: 63 LGALSDRFGRRPVLLVSLAGAAVDYAIMATA---PFLWVLYIGRIVAGITGATGAVAGAY 119 Query: 162 ITDLSTSDTKAYNMSIMSLAFSAGVIVGPVLGGVTSDRTISPLFDYGTPFMLVAALSLIC 221 I D++ D +A + MS F G++ GPVLGG+ SP PF AAL+ + Sbjct: 120 IADITDGDERARHFGFMSACFGFGMVAGPVLGGLMGG--FSP----HAPFFAAAALNGLN 173 Query: 222 ACWTWAAYRDSAAPRGDT-RIDPLLPLRIIVEAARQRDVAFLSVVFFLMQVGYGLYLQTI 280 +S R + L PL A VA L VFF+MQ+ + Sbjct: 174 FLTGCFLLPESHKGERRPLRREALNPLASFRWARGMTVVAALMAVFFIMQLVGQVPAALW 233 Query: 281 MLLLQAKFGYTSARLGLFSGVIGLCFVFGLLCVVRLMLRVWRVIDIAKTGLLVAGLGQIL 340 ++ + +F + + +G+ G+ + + G++ G G IL Sbjct: 234 VIFGEDRFHWDATTIGISLAAFGILHSLAQAMITGPVAARLGERRALMLGMIADGTGYIL 293 Query: 341 SALFPHEPVLWALAMVVGCFDMV--AYTTMYTAFSDAVSDDRQGWALGVAGSVMAVAWVV 398 A + + + +++ + A M S V ++RQG G ++ ++ +V Sbjct: 294 LAFATRGWMAFPIMVLLASGGIGMPALQAM---LSRQVDEERQGQLQGSLAALTSLTSIV 350
>ACRIFLAVINRP#Acriflavin resistance protein family signature. Length = 1034 Score = 1000 bits (2586), Expect = 0.0 Identities = 433/1045 (41%), Positives = 621/1045 (59%), Gaps = 20/1045 (1%) Query: 4 SRFFIDRPIFAVVLSIVIFALGLISIPMLPAGEYPEVVPPSVVVRATYPGANPKEIAESV 63 + FFI RPIFA VL+I++ G ++I LP +YP + PP+V V A YPGA+ + + ++V Sbjct: 2 ANFFIRRPIFAWVLAIILMMAGALAILQLPVAQYPTIAPPAVSVSANYPGADAQTVQDTV 61 Query: 64 AEPLEEAINGVEGIMYMKSVAGSDGSLQVVVTFLQGVDPDTAAVRVQNRVSQALSRLPDE 123 + +E+ +NG++ +MYM S + S GS+ + +TF G DPD A V+VQN++ A LP E Sbjct: 62 TQVIEQNMNGIDNLMYMSSTSDSAGSVTITLTFQSGTDPDIAQVQVQNKLQLATPLLPQE 121 Query: 124 VRQYGVTTQKQSPTPLMYVSLYSPDNSRDSLYLRNYLTLHVKDELSRLTGIGDVGVYGSG 183 V+Q G++ +K S + LM S + + +Y+ +VKD LSRL G+GDV ++G Sbjct: 122 VQQQGISVEKSSSSYLMVAGFVSDNPGTTQDDISDYVASNVKDTLSRLNGVGDVQLFG-A 180 Query: 184 DYAMRLWLDPNRLASRGLTASDVIAAVREQNVQVSAGQLGAEPSPKKNDFLVSINVRGRL 243 YAMR+WLD + L LT DVI ++ QN Q++AGQLG P+ SI + R Sbjct: 181 QYAMRIWLDADLLNKYKLTPVDVINQLKVQNDQIAAGQLGGTPALPGQQLNASIIAQTRF 240 Query: 244 RTVQEFSDIVLRNGDDGQVVKLSDVARIELGAGDYTLRSYFNDRHSAVVGIFLSPGANAL 303 + +EF + LR DG VV+L DVAR+ELG +Y + + N + +A +GI L+ GANAL Sbjct: 241 KNPEEFGKVTLRVNSDGSVVRLKDVARVELGGENYNVIARINGKPAAGLGIKLATGANAL 300 Query: 304 DVAKAVYAKLDELSKRFPPGVAYRPVWDPTVFVRESIRAVQHTLIEAVVLVVLVVILFLQ 363 D AKA+ AKL EL FP G+ +D T FV+ SI V TL EA++LV LV+ LFLQ Sbjct: 301 DTAKAIKAKLAELQPFFPQGMKVLYPYDTTPFVQLSIHEVVKTLFEAIMLVFLVMYLFLQ 360 Query: 364 TWRASIIPLVAVPVSVVGTFAWLYLLGYSINTLTLFGLVLAIGIVVDDAIVVVENVERNI 423 RA++IP +AVPV ++GTFA L GYSINTLT+FG+VLAIG++VDDAIVVVENVER + Sbjct: 361 NMRATLIPTIAVPVVLLGTFAILAAFGYSINTLTMFGMVLAIGLLVDDAIVVVENVERVM 420 Query: 424 A-QGLSPRDAAHQAMREVSGPIVAIALVLCAVFVPMAFMSGVTGQFYKQFAVTIAISTVI 482 L P++A ++M ++ G +V IA+VL AVF+PMAF G TG Y+QF++TI + + Sbjct: 421 MEDKLPPKEATEKSMSQIQGALVGIAMVLSAVFIPMAFFGGSTGAIYRQFSITIVSAMAL 480 Query: 483 SAINSLTLSPALAAKLLRPHGAPKDALTRALDRAFGWLFHPFNRFFERSSDRYHGVVGRT 542 S + +L L+PAL A LL+P A FGW FN F+ S + Y VG+ Sbjct: 481 SVLVALILTPALCATLLKPVSAEHHENKGGF---FGW----FNTTFDHSVNHYTNSVGKI 533 Query: 543 LKRRGVVFAVYAALLAATALLFNAVPGGFIPVQDKLYLFAGAKLPEGASLARTSAVTEQM 602 L G +YA ++A +LF +P F+P +D+ +LP GA+ RT V +Q+ Sbjct: 534 LGSTGRYLLIYALIVAGMVVLFLRLPSSFLPEEDQGVFLTMIQLPAGATQERTQKVLDQV 593 Query: 603 TKIALGT--DGVEMVPAFAGLNALQGVNTPNITNSYVILKPFDQRHR---TAAQINADLN 657 T L VE V G + N ++V LKP+++R+ +A + Sbjct: 594 TDYYLKNEKANVESVFTVNGFSF--SGQAQNAGMAFVSLKPWEERNGDENSAEAVIHRAK 651 Query: 658 ARFAAIDGGITYALMPPPIQGLGNGSGYSLYLEDRGGLGYGELQKALTAFQAAVAKTPGM 717 I G P I LG +G+ L D+ GLG+ L +A A+ P Sbjct: 652 MELGKIRDGFVIPFNMPAIVELGTATGFDFELIDQAGLGHDALTQARNQLLGMAAQHPAS 711 Query: 718 SYPV-SSYQANIPQLEVKVDRLKAKAQGVALTDLFNTLQVYLGSMYVNDFNVFGRVYRVM 776 V + + Q +++VD+ KA+A GV+L+D+ T+ LG YVNDF GRV ++ Sbjct: 712 LVSVRPNGLEDTAQFKLEVDQEKAQALGVSLSDINQTISTALGGTYVNDFIDRGRVKKLY 771 Query: 777 AQADAGHRQTAADIANLRTRNAKGEMVPIGSMVTVGPAYGPDPVVRYNGYPAADLIGDAD 836 QADA R D+ L R+A GEMVP + T YG + RYNG P+ ++ G+A Sbjct: 772 VQADAKFRMLPEDVDKLYVRSANGEMVPFSAFTTSHWVYGSPRLERYNGLPSMEIQGEAA 831 Query: 837 PKAMSSSQAIAKLQQIAKDVLPPGITLEWTDLSYQQVTQSNAAIVVFPLAVMLVFLVLAS 896 P SS A+A ++ +A LP GI +WT +SYQ+ N A + ++ ++VFL LA+ Sbjct: 832 PGT-SSGDAMALMENLASK-LPAGIGYDWTGMSYQERLSGNQAPALVAISFVVVFLCLAA 889 Query: 897 LYESWTLPLAVILIVPVCMCAALFGVWLSGGDNNVFVQVGLVVLMGLACKNAILIVEFAR 956 LYESW++P++V+L+VP+ + L L N+V+ VGL+ +GL+ KNAILIVEFA+ Sbjct: 890 LYESWSIPVSVMLVVPLGIVGVLLAATLFNQKNDVYFMVGLLTTIGLSAKNAILIVEFAK 949 Query: 957 EL-EIQGKGVVEAALEACKLRLRPIVMTSVAFIAGSVPLLIGSGAGSEVRAATGVTVFAG 1015 +L E +GKGVVEA L A ++RLRPI+MTS+AFI G +PL I +GAGS + A G+ V G Sbjct: 950 DLMEKEGKGVVEATLMAVRMRLRPILMTSLAFILGVLPLAISNGAGSGAQNAVGIGVMGG 1009 Query: 1016 MLGVTLFGLFLTPVFYVAIRKLAGG 1040 M+ TL +F PVF+V IR+ G Sbjct: 1010 MVSATLLAIFFVPVFFVVIRRCFKG 1034 Score = 85.3 bits (211), Expect = 7e-19 Identities = 63/329 (19%), Positives = 117/329 (35%), Gaps = 23/329 (6%) Query: 730 QLEVKVDRLKAKAQGVALTDLFNTLQ---VYLGSMYVNDFNVFGRVYRVMAQADAGHRQT 786 + + +D + D+ N L+ + + + + + Sbjct: 183 AMRIWLDADLLNKYKLTPVDVINQLKVQNDQIAAGQLGGTPALPGQQLNASIIAQTRFKN 242 Query: 787 AADIANLRTR-NAKGEMVPIGSMVTVGPAYGPDP-VVRYNGYPAADLI----GDADPKAM 840 + + R N+ G +V + + V + R NG PAA L A+ Sbjct: 243 PEEFGKVTLRVNSDGSVVRLKDVARVELGGENYNVIARINGKPAAGLGIKLATGANALDT 302 Query: 841 SSS--QAIAKLQQIAKDVLPPGITLEWTDLSYQQVTQSNAAI--VVFPL--AVMLVFLVL 894 + + +A+LQ P G+ + + Y +I VV L A+MLVFLV+ Sbjct: 303 AKAIKAKLAELQPF----FPQGMKVLYP---YDTTPFVQLSIHEVVKTLFEAIMLVFLVM 355 Query: 895 ASLYESWTLPLAVILIVPVCMCAALFGVWLSGGDNNVFVQVGLVVLMGLACKNAILIVE- 953 ++ L + VPV + + G N G+V+ +GL +AI++VE Sbjct: 356 YLFLQNMRATLIPTIAVPVVLLGTFAILAAFGYSINTLTMFGMVLAIGLLVDDAIVVVEN 415 Query: 954 FARELEIQGKGVVEAALEACKLRLRPIVMTSVAFIAGSVPLLIGSGAGSEVRAATGVTVF 1013 R + EA ++ +V ++ A +P+ G+ + +T+ Sbjct: 416 VERVMMEDKLPPKEATEKSMSQIQGALVGIAMVLSAVFIPMAFFGGSTGAIYRQFSITIV 475 Query: 1014 AGMLGVTLFGLFLTPVFYVAIRKLAGGTP 1042 + M L L LTP + K Sbjct: 476 SAMALSVLVALILTPALCATLLKPVSAEH 504
>RTXTOXIND#Gram-negative bacterial RTX secretion protein D signature. Length = 478 Score = 43.7 bits (103), Expect = 8e-07 Identities = 18/130 (13%), Positives = 46/130 (35%), Gaps = 28/130 (21%) Query: 67 ELRPRVSGYLQRVAYKEGDVVAQGALLFEIDPRPYRIALDRANAQQQRARAAA------- 119 E++P + ++ + KEG+ V +G +L ++ + + +AR Sbjct: 98 EIKPIENSIVKEIIVKEGESVRKGDVLLKLTALGAEADTLKTQSSLLQARLEQTRYQILS 157 Query: 120 --------------------SLANVQLKRVQTLIDAH-ATSQEELDNARATAEQARADLQ 158 +++ ++ R+ +LI +T Q + ++ RA+ Sbjct: 158 RSIELNKLPELKLPDEPYFQNVSEEEVLRLTSLIKEQFSTWQNQKYQKELNLDKKRAERL 217 Query: 159 AADAAVADAK 168 A + + Sbjct: 218 TVLARINRYE 227 Score = 43.7 bits (103), Expect = 1e-06 Identities = 19/114 (16%), Positives = 42/114 (36%), Gaps = 10/114 (8%) Query: 109 NAQQQRARAAASLANVQLKRVQTLIDAHATSQEELDNARATAE--------QARADLQAA 160 + + A L V +++ + +++EE + Q ++ Sbjct: 256 EQENKYVEAVNELR-VYKSQLEQIESEILSAKEEYQLVTQLFKNEILDKLRQTTDNIGLL 314 Query: 161 DAAVADAKLNLGFTEVRAPIAGRV-GRAVATVGNLARADDTLLTTVVSQDPVYV 213 +A + + +RAP++ +V V T G + +TL+ V D + V Sbjct: 315 TLELAKNEERQQASVIRAPVSVKVQQLKVHTEGGVVTTAETLMVIVPEDDTLEV 368
>DHBDHDRGNASE#2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase signature. Length = 261 Score = 75.9 bits (186), Expect = 2e-18 Identities = 74/258 (28%), Positives = 110/258 (42%), Gaps = 18/258 (6%) Query: 8 RTAIVTGGSSGIGFAIASRLVQDGYRVAIVGRDAARLEAAVARLGGAAIGQVGDLSVRHD 67 + A +TG + GIG A+A L G +A V + +LE V+ L A + D Sbjct: 9 KIAFITGAAQGIGEAVARTLASQGAHIAAVDYNPEKLEKVVSSLKAEARHAEAFPADVRD 68 Query: 68 AEAVVAAIVARW----PRIDVLVNNAGLTGRVGADTKAGEAEAVWDAVLHANLKSLFLTT 123 + A+ I AR ID+LVN AG+ R G + E W+A N +F + Sbjct: 69 SAAI-DEITARIEREMGPIDILVNVAGVL-RPGLIHSLSDEE--WEATFSVNSTGVFNAS 124 Query: 124 MAVLPHVAD-RAARIVNIGSIAARAGSLLPGGLAYAAAKAGVEGFTVALARELGPRGATV 182 +V ++ D R+ IV +GS A AYA++KA FT L EL Sbjct: 125 RSVSKYMMDRRSGSIVTVGSNPAGVPRTSMA--AYASSKAAAVMFTKCLGLELAEYNIRC 182 Query: 183 NTVAPGYIAG-------TRFFGDSGVAPAVAAMIRVQTPVGRAGQPDDVADAVAWLAGPR 235 N V+PG G V + P+ + +P D+ADAV +L + Sbjct: 183 NIVSPGSTETDMQWSLWADENGAEQVIKGSLETFKTGIPLKKLAKPSDIADAVLFLVSGQ 242 Query: 236 ASFVTGATIAVNGGWRVG 253 A +T + V+GG +G Sbjct: 243 AGHITMHNLCVDGGATLG 260
>HTHTETR#TetR bacterial regulatory protein HTH signature. Length = 215 Score = 68.9 bits (168), Expect = 2e-16 Identities = 34/205 (16%), Positives = 66/205 (32%), Gaps = 12/205 (5%) Query: 9 PSKRRTRGRPLADASVGPDVILRAARRTFAKRGYDATSVREVARELGIDAALIAHHFGTK 68 K + + IL A R F+++G +TS+ E+A+ G+ I HF K Sbjct: 2 ARKTKQEAQETRQH------ILDVALRLFSQQGVSSTSLGEIAKAAGVTRGAIYWHFKDK 55 Query: 69 ETLWLAVVEQIVELAEPMFDALRALRASSLPH--RDRVRRALELCVDHEFAEPDI--GMF 124 L+ + E + +A R+ + LE V E + +F Sbjct: 56 SDLFSEIWELSESNIGELELEYQAKFPGDPLSVLREILIHVLESTV-TEERRRLLMEIIF 114 Query: 125 FSTAATEEGGRLDRLQERIVRPYHDAMFPLLADAVEAGAIRP-VDPNVLFFMIASAIGTT 183 E + + Q + +D + L +EA + + ++ I Sbjct: 115 HKCEFVGEMAVVQQAQRNLCLESYDRIEQTLKHCIEAKMLPADLMTRRAAIIMRGYISGL 174 Query: 184 VSYSHMMLEYTSLPTRPEAFREAVL 208 + + L + +L Sbjct: 175 MENWLFAPQSFDLKKEARDYVAILL 199
>TCRTETA#Tetracycline resistance protein signature. Length = 399 Score = 30.6 bits (69), Expect = 0.014 Identities = 75/359 (20%), Positives = 136/359 (37%), Gaps = 52/359 (14%) Query: 82 IGAYADRVGRKPALVLTVALMALGTGIIGFAPTYAQIGIAAPLLIVIGRLLQGFSAGGEV 141 +GA +DR GR+P L++++A A+ I+ AP ++ IGR++ G + G Sbjct: 63 LGALSDRFGRRPVLLVSLAGAAVDYAIMATAPFLW--------VLYIGRIVAGIT-GATG 113 Query: 142 GAATTLLMESGGARRSGELVSWQMASQGGAALAGALVALTLSRWLPSDALQGWGWRVPFV 201 A + + + A G +AG ++ + + P PF Sbjct: 114 AVAGAYIADITDGDERARHFGFMSACFGFGMVAGPVLGGLMGGFSP---------HAPFF 164 Query: 202 LGLLIGPVGFYLRRHLDDTLPHPAAGAPRVSRRIPWRQVAAGTLLVIGGTSTMYTIVFFL 261 + + F L LP G R P R+ A L M + + Sbjct: 165 AAAALNGLNFLTGCFL---LPESHKG-----ERRPLRREALNPLASFRWARGMTVVAALM 216 Query: 262 PSFLTLTL--GMPASVALLSG--------------CTAGAVM--LVGSPFAGRFADRLRR 303 F + L +PA++ ++ G A ++ L + G A RL Sbjct: 217 AVFFIMQLVGQVPAALWVIFGEDRFHWDATTIGISLAAFGILHSLAQAMITGPVAARLGE 276 Query: 304 RKPMLRTVCAISTALVLPAFHAMRTWPSVVTVLAVVVVLIGLMTLSSPAGFVMILEALRP 363 R+ ++ + A T +L AF A R W + ++VL+ + PA M+ + Sbjct: 277 RRALMLGMIADGTGYILLAF-ATRGW-----MAFPIMVLLASGGIGMPALQAMLSRQVDE 330 Query: 364 EVRATSLGMIYALGVTIFGGFAQLIVSALWRATGSFYAPAWYVLAGGSASLVGLALFRE 422 E + G + AL ++ L+ +A++ A+ + W +AG + L+ L R Sbjct: 331 ERQGQLQGSLAAL-TSLTSIVGPLLFTAIYAASIT-TWNGWAWIAGAALYLLCLPALRR 387
>ECOLNEIPORIN#E.coli/Neisseria porin superfamily signature. Length = 331 Score = 54.8 bits (132), Expect = 2e-10 Identities = 65/323 (20%), Positives = 117/323 (36%), Gaps = 46/323 (14%) Query: 43 VALYGSVDMGINYQS-VGGRSTWQTQSG-----GEWTSKFGFFGRENLGGGWRAEFNLES 96 V LYG++ G+ V + SK GF G+E+LG G +A + +E Sbjct: 21 VTLYGTIKAGVETSRSVAHNGAQAASVETGTGIVDLGSKIGFKGQEDLGNGLKAIWQVEQ 80 Query: 97 GFLANNGAQQDTQSFFNRQSWIGLMSDRYGRLRLGKQIGTGLPLFIDVFGTVGTNSVYTW 156 + A D+ NRQS+IGL +G+LR+G+ + D +S + Sbjct: 81 K---ASIAGTDSGW-GNRQSFIGLKGG-FGKLRVGRLNS----VLKDTGDINPWDSKSDY 131 Query: 157 LGAAAVQTARGVGYNSDLGPGATQLPARVDN---AITYRTPIVAGTTTLMLMYAPSNVAG 213 LG + A + ++ Y +P AG + + YA ++ AG Sbjct: 132 LGVNKI--------------------AEPEARLISVRYDSPEFAGLSG-SVQYALNDNAG 170 Query: 214 RAPAASAQGALLQWYNGTTYLAASY---NQVWGVNGASTVRNDLYGLGAVYDTGRLVLSA 270 R + + A + NG ++ + + ++ L + YD L S Sbjct: 171 R-HNSESYHAGFNYKNGGFFVQYGGAYKRHHQVQENVNIEKYQIHRLVSGYDNDALYASV 229 Query: 271 SFNQYAPKLAGDGIARVYT--LGTIVPFGVNAVRASIVYRDTSGVRDAAGRPAKDSALGV 328 + Q KL + + + + + V + Y + V Sbjct: 230 AVQQQDAKLVEENYSHNSQTEVAATLAYRFGNVTPRVSYAHGFK-GSFDATNYNNDYDQV 288 Query: 329 MLGYDYLLSKRTGLYARTGFIRN 351 ++G +Y SKRT G+++ Sbjct: 289 VVGAEYDFSKRTSALVSAGWLQE 311
>OMPTIN#Omptin serine protease signature. Length = 317 Score = 33.4 bits (76), Expect = 0.001 Identities = 24/119 (20%), Positives = 48/119 (40%), Gaps = 17/119 (14%) Query: 235 AAVVTVGTFHAGTAPNVIPETATLQLSVRSLDAATRDEVEARIRRIADAQARAYGTVAQV 294 + + +F + + P+ +S+ +L T++ V +A+ R V+Q+ Sbjct: 11 TTPIAISSFASTETLSFTPDNINADISLGTLSGKTKERV-----YLAEEGGR---KVSQL 62 Query: 295 DYQAISRVVVNDAA--AADLAVETITALA-GAGGLTLLADGVMGSEDFSWMTERVPGCY 350 D++ N+AA + + + ++ GA G T L D WM PG + Sbjct: 63 DWK------FNNAAIIKGAINWDLMPQISIGAAGWTTLGSRGGNMVDQDWMDSSNPGTW 115
>SACTRNSFRASE#Streptothricin acetyltransferase signature. Length = 173 Score = 37.6 bits (87), Expect = 7e-06 Identities = 25/109 (22%), Positives = 41/109 (37%), Gaps = 18/109 (16%) Query: 41 EPTDAAAVLVRIDDGRAYVAVDPQGTCVGFAFYRLLDAQRLYLEELDVAPSHAGQRIGAR 100 E AA L +++ C+G R +E++ VA + + +G Sbjct: 61 EEEGKAAFLYYLEN-----------NCIGRIKIRSNWNGYALIEDIAVAKDYRKKGVGTA 109 Query: 101 LIEQVIARAAREHVEQVVLSTFRDAPWNAP---YYARLGFRIID-DTAL 145 L+ + I A H ++L T N +YA+ F I DT L Sbjct: 110 LLHKAIEWAKENHFCGLMLETQDI---NISACHFYAKHHFIIGAVDTML 155
>HTHTETR#TetR bacterial regulatory protein HTH signature. Length = 215 Score = 29.2 bits (65), Expect = 0.018 Identities = 21/114 (18%), Positives = 39/114 (34%), Gaps = 4/114 (3%) Query: 10 VTASDVAARAGVSRSAVSRAFSPTASIAPQTRERVMVAARAL--GYQVNLIARDMITQRS 67 + ++A AGV+R A+ F + + + E L YQ + R Sbjct: 32 TSLGEIAKAAGVTRGAIYWHFKDKSDLFSEIWELSESNIGELELEYQAKFPGDPLSVLRE 91 Query: 68 SMIGVVTAGFENPFRARLLSDLMAALGQRALTPLVTNAED--PRQVRQSLEQLL 119 +I V+ + R L+ + +V A+ + +EQ L Sbjct: 92 ILIHVLESTVTEERRRLLMEIIFHKCEFVGEMAVVQQAQRNLCLESYDRIEQTL 145
>VACCYTOTOXIN#Helicobacter pylori vacuolating cytotoxin signature. Length = 1291 Score = 31.9 bits (72), Expect = 0.003 Identities = 14/40 (35%), Positives = 18/40 (45%), Gaps = 3/40 (7%) Query: 62 APTFEHFASVWANGIGAPLFNSLLVGFGTTLLALALAFPA 101 AP +E +VWAN IG NS G +L + A Sbjct: 1016 APKYEKPTNVWANAIGGTSLNS---GGNASLYGTSAGVDA 1052
>ECOLNEIPORIN#E.coli/Neisseria porin superfamily signature. Length = 331 Score = 68.7 bits (168), Expect = 6e-15 Identities = 77/355 (21%), Positives = 117/355 (32%), Gaps = 45/355 (12%) Query: 21 AQTSGSVTLYGTVDTGIIYSTNQQFTRADGSTGGGHAWQMGGGNLVPSRFGFQGAEPLGG 80 VTLYGT+ G+ S + + G + S+ GF+G E LG Sbjct: 15 VAAMADVTLYGTIKAGVETSRSVA-HNGAQAASVETG---TGIVDLGSKIGFKGQEDLGN 70 Query: 81 GLDAVFTLEQQFLSANGQALQGGTAFSRQAWVGLRQEGIGTLGLGRQYDSYTDMLGAYVS 140 GL A++ +EQ+ A +RQ+++GL+ G G L +GR D Sbjct: 71 GLKAIWQVEQK----ASIAGTDSGWGNRQSFIGLKG-GFGKLRVGRLNSVLKD----TGD 121 Query: 141 SNNWSTPYGSHLGDVDNLNAAFNFNNAVKFTSADFNGLTFGGTFSFGGQAGDFSAKRGYA 200 N W +LG V+ + +V++ S +F GL+ ++ AG Y Sbjct: 122 INPW-DSKSDYLG-VNKIAEPEARLISVRYDSPEFAGLSGSVQYALNDNAG-RHNSESYH 178 Query: 201 VAATYTRAPVAFSVGYLDLHQPLDAALGGASSYIGDFACSNPGAMYCLLQDAGSMRAFGA 260 Y G Y + Y D ++ A A Sbjct: 179 AGFNYKNGGFFVQYGGAYKRHHQVQENVNIEKY----QIHRLVSGY----DNDALYASVA 230 Query: 261 GGSVTLGAATVALTYTHTRLGDSRYFSTAAQPRTQAFTFDIGELNVTYMFTPALQGGVAY 320 A V Y+H AA + G + TP + A+ Sbjct: 231 --VQQQDAKLVEENYSHN-----SQTEVAAT-----LAYRFGNV------TPRV--SYAH 270 Query: 321 IFNAAHTDGRGTTRFHQVNVGANYSLSKRTALYAVAIGQVASGTGLGTDADGNAA 375 F + + QV VGA Y SKRT+ V+ G + G G Sbjct: 271 GFKGSFDATNYNNDYDQVVVGAEYDFSKRTSAL-VSAGWLQEGKGESKFVSTAGG 324
>HTHTETR#TetR bacterial regulatory protein HTH signature. Length = 215 Score = 55.8 bits (134), Expect = 7e-12 Identities = 35/201 (17%), Positives = 74/201 (36%), Gaps = 15/201 (7%) Query: 16 PRQRRSVATVDAIVEAAARILERDGFDGYTTNAVAALAGVSIGSLYQYFPNRDALTAALV 75 ++ + T I++ A R+ + G + +A AGV+ G++Y +F ++ L + + Sbjct: 4 KTKQEAQETRQHILDVALRLFSQQGVSSTSLGEIAKAAGVTRGAIYWHFKDKSDLFSEIW 63 Query: 76 ERESAHLLDDVE----------RAAALSSCDDVLRALVRGAVAHQMRRPVLARLIDFEEA 125 E +++ + + VL + V + + + E Sbjct: 64 ELSESNIGELELEYQAKFPGDPLSVLREILIHVLESTVTEERRRLLMEIIFHKCEFVGEM 123 Query: 126 RLPLGART---ERVADRIHATLLHALGARDAPRVAAPDVVAHDLLAIVKGIVDAAGARGE 182 + A+ DRI TL H + A+ P A + + G+++ + Sbjct: 124 AVVQQAQRNLCLESYDRIEQTLKHCIEAKMLPADLMTRRAAIIMRGYISGLMENWLFAPQ 183 Query: 183 TDANALEARAWRAV--RGYLR 201 + EAR + A+ YL Sbjct: 184 SFDLKKEARDYVAILLEMYLL 204
>TCRTETB#Tetracycline resistance protein TetB signature. Length = 458 Score = 116 bits (291), Expect = 3e-30 Identities = 86/407 (21%), Positives = 166/407 (40%), Gaps = 15/407 (3%) Query: 18 LIVACAL-FMESVDANIIVTALPAMARDFGHNPVTLNIAITAYVVGLGVFIPICGWLADR 76 LI C L F ++ ++ +LP +A DF P + N TA+++ + + G L+D+ Sbjct: 16 LIWLCILSFFSVLNEMVLNVSLPDIANDFNKPPASTNWVNTAFMLTFSIGTAVYGKLSDQ 75 Query: 77 FSARAVFRTAIGIFVVGSLMCAASNS-LGVLTFARFIQGVGGAMMVPVGRIIIFRAVPRA 135 + + I I GS++ +S +L ARFIQG G A + +++ R +P+ Sbjct: 76 LGIKRLLLFGIIINCFGSVIGFVGHSFFSLLIMARFIQGAGAAAFPALVMVVVARYIPKE 135 Query: 136 DLVRAMNYLAIPALFGPTVGPLVGGFITTYLHWRMIFFINVPIGIYGIYLASKHIANTHE 195 + +A + G VGP +GG I Y+HW + I + I I + K + Sbjct: 136 NRGKAFGLIGSIVAMGEGVGPAIGGMIAHYIHWSYLLLIPM-ITIITVPFLMKLLKKEVR 194 Query: 196 PDPGPLDWFGFLLSASGAALLLMGLTLIDGSLTSRSNAIIMCAAGAAMLALYVPYARRKE 255 G D G +L + G ++ T S +I ++V + R+ Sbjct: 195 IK-GHFDIKGIILMSVGIVFFMLFTT---------SYSISFLIVSVLSFLIFVKHIRKVT 244 Query: 256 RPVLDLSFLKIPTYHASVVGGSLFRIGLGAVPFLLPLALQEGLGMSAFHSG-LITCASAL 314 P +D K + V+ G + + ++P +++ +S G +I + Sbjct: 245 DPFVDPGLGKNIPFMIGVLCGGIIFGTVAGFVSMVPYMMKDVHQLSTAEIGSVIIFPGTM 304 Query: 315 GGAVSRSTATHTLRRFGFRTVLIYNAAFAGLAIAAYGVFHPGMATWAIWLIVLVGGIFPA 374 + + R G VL F ++ + + +IV V G Sbjct: 305 SVIIFGYIGGILVDRRGPLYVLNIGVTFLSVSFLTASFLLETTSWFMTIIIVFVLGGLSF 364 Query: 375 LQFTSLNSMIYADISPRDAGRATSLGSVVQQMSLGLGVTVAGLVLHV 421 + T +++++ + + ++AG SL + +S G G+ + G +L + Sbjct: 365 TK-TVISTIVSSSLKQQEAGAGMSLLNFTSFLSEGTGIAIVGGLLSI 410
>DHBDHDRGNASE#2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase signature. Length = 261 Score = 49.7 bits (118), Expect = 3e-09 Identities = 45/185 (24%), Positives = 68/185 (36%), Gaps = 7/185 (3%) Query: 6 KRGLVVGIANGQSIAWGCARAFCRAGATL-AVTWQSDKTLPHVEPLFAQLDAPIRMPLDV 64 K + G A G I AR GA + AV + +K V L A+ P DV Sbjct: 9 KIAFITGAAQG--IGEAVARTLASQGAHIAAVDYNPEKLEKVVSSLKAEARHAEAFPADV 66 Query: 65 GRSDQMAAVFDAIAVQWGAIDFVLHSVAYAPKADLQGRVVDSSPEGFSLAMDTSCHSFIR 124 S + + I + G ID +++ + + FS+ S F Sbjct: 67 RDSAAIDEITARIEREMGPIDILVNVAGVLRPGLIHSLSDEEWEATFSV---NSTGVFNA 123 Query: 125 MARLAEPLMT-RGGSLMAMSYLGAEQVVANYGVMGPVKAALEASVRYLAAELGGAGIRVN 183 +++ +M R GS++ + A + KAA + L EL IR N Sbjct: 124 SRSVSKYMMDRRSGSIVTVGSNPAGVPRTSMAAYASSKAAAVMFTKCLGLELAEYNIRCN 183 Query: 184 AVSPG 188 VSPG Sbjct: 184 IVSPG 188
>ACETATEKNASE#Acetate kinase family signature. Length = 400 Score = 357 bits (918), Expect = e-123 Identities = 151/398 (37%), Positives = 226/398 (56%), Gaps = 16/398 (4%) Query: 5 VLVLNAGSSSLKFSVYDTHEDCSLDAGLHGQVENLHDTPHLFVTDAHGATLADSAVARPG 64 +LV+N GSSSLK+ + ++ + L GL E + +T Sbjct: 3 ILVINCGSSSLKYQLIESKDGNVLAKGL---AERIG-INDSLLTHNANGEKIKIKKDMKD 58 Query: 65 HQGAI-EALHAWFAAHVG---REAALDGVGHRVVHGGPYFTAPVRIDARVLDAIAALAPL 120 H+ AI L A + G + +D VGHRVVHGG YFT+ V I VL AI L Sbjct: 59 HKDAIKLVLDALVNSDYGVIKDMSEIDAVGHRVVHGGEYFTSSVLITDDVLKAITDCIEL 118 Query: 121 APLHQPHHVDAIRAVAAVAPNLPQVACFDTAFHATVPALEREFALPRAL-TEQGIVRYGF 179 APLH P +++ I+A + P++P VA FDTAFH T+P + +P T+ I +YGF Sbjct: 119 APLHNPANIEGIKACTQIMPDVPMVAVFDTAFHQTMPDYAYLYPIPYEYYTKYKIRKYGF 178 Query: 180 HGLSYEYIATALAA-LDPSWMQHRTVVAHLGNGASLCALANGRSVATTMGFTAVDGLPMG 238 HG S++Y++ A L+ + + HLGNG+S+ A+ NG+S+ T+MGFT ++GL MG Sbjct: 179 HGTSHKYVSQRAAEILNKPIESLKIITCHLGNGSSIAAVKNGKSIDTSMGFTPLEGLAMG 238 Query: 239 TRTGALDPGVILYLQRHTGRSLDEVEHLIYAESGLLGVSGVSSDMRTLLASDA----PSA 294 TR+G++DP +I YL S +EV +++ +SG+ G+SG+SSD R L + A Sbjct: 239 TRSGSIDPSIISYLMEKENISAEEVVNILNKKSGVYGISGISSDFRDLEDAAFKNGDKRA 298 Query: 295 AHAVELFAYRAARELAALAGVLGGLDTLVFTAGIGEHAPRVRERICRRAAWLGIVLDDAA 354 A+ +FAYR + + + A +GG+D +VFTAGIGE+ P +RE I +LG LD Sbjct: 299 QLALNVFAYRVKKTIGSYAAAMGGVDVIVFTAGIGENGPEIREFILDGLEFLGFKLDKEK 358 Query: 355 N-AAGLP-VMSSDASRVTVRVIPTDENLMIARHTRRVL 390 N G ++S+ S+V V V+PT+E MIA+ T +++ Sbjct: 359 NKVRGEEAIISTADSKVNVMVVPTNEEYMIAKDTEKIV 396
>SACTRNSFRASE#Streptothricin acetyltransferase signature. Length = 173 Score = 33.8 bits (77), Expect = 1e-04 Identities = 15/59 (25%), Positives = 25/59 (42%), Gaps = 2/59 (3%) Query: 61 GWLHVDLLVVPEAARGQGAGTRIMDLAEREAVARGCHSAWLDTFDFQ--ARPFYEKRGY 117 G+ ++ + V + R +G GT ++ A A L+T D A FY K + Sbjct: 88 GYALIEDIAVAKDYRKKGVGTALLHKAIEWAKENHFCGLMLETQDINISACHFYAKHHF 146
>HTHFIS#FIS bacterial regulatory protein HTH signature. Length = 484 Score = 93.0 bits (231), Expect = 3e-24 Identities = 31/127 (24%), Positives = 59/127 (46%) Query: 2 RVLLVEDDPLIGSGLEQGLKQEGFAVDWVKDGDAASLALRATGYGLLLLDLGLPNRDGLS 61 +L+ +DD I + L Q L + G+ V + + A L++ D+ +P+ + Sbjct: 5 TILVADDDAAIRTVLNQALSRAGYDVRITSNAATLWRWIAAGDGDLVVTDVVMPDENAFD 64 Query: 62 VLAALRRRDENLPAIIITARDGVPDRIAGLDSGADDYLVKPFELDELLARIRAVNRRHAG 121 +L +++ +LP ++++A++ I + GA DYL KPF+L EL+ I Sbjct: 65 LLPRIKKARPDLPVLVMSAQNTFMTAIKASEKGAYDYLPKPFDLTELIGIIGRALAEPKR 124 Query: 122 RAQTTLA 128 R Sbjct: 125 RPSKLED 131
>PF06580#Sensor histidine kinase Length = 349 Score = 39.5 bits (92), Expect = 2e-05 Identities = 19/108 (17%), Positives = 37/108 (34%), Gaps = 23/108 (21%) Query: 350 LLNNLVDNAIRYA----GEGARVDVSARIDGTTPVLEVADDGPGIPEAERTDVWERFYRG 405 L+ LV+N I++ +G ++ + D T LEV + G + + Sbjct: 259 LVQTLVENGIKHGIAQLPQGGKILLKGTKDNGTVTLEVENTGSLALKNTK---------- 308 Query: 406 EGAQAATSSGSGLGLSIV-KRIAEQHRASVALGTTRGGRGLTVTVRFP 452 +G GL V +R+ + + + + V P Sbjct: 309 --------ESTGTGLQNVRERLQMLYGTEAQIKLSEKQGKVNAMVLIP 348
>TYPE4SSCAGA#Type IV secretion system CagA exotoxin signature. Length = 1147 Score = 30.8 bits (69), Expect = 0.009 Identities = 15/48 (31%), Positives = 25/48 (52%), Gaps = 1/48 (2%) Query: 96 GGIPFELHSP-DDMSLIGVVVEPELMQQIEDAADVRLDARALRHGVVE 142 G P + H DD+S +G+ EL Q+I++ +A+A G +E Sbjct: 940 AGFPLKRHDKVDDLSKVGLSRNQELAQKIDNLNQAVSEAKAGFFGNLE 987
>THERMOLYSIN#Thermolysin metalloprotease (M4) family signature. Length = 544 Score = 65.8 bits (160), Expect = 2e-13 Identities = 91/488 (18%), Positives = 168/488 (34%), Gaps = 65/488 (13%) Query: 109 VVTSERNDADFTVVRLQQQAAGLPVYGSDIAVTVAKDGRILYVASNTISGVVA-TTRKSQ 167 ++ ++ ++ TV+R +Q A G+ + V DG + ++ I + T + Sbjct: 78 LIGNKLDELGHTVMRFEQAIAASLCMGAVLVAHV-NDGELSSLSGTLIPNLDKRTLKTEA 136 Query: 168 AVDQQQALDRARAYLGVSGFTHL-------DAQLVAFVDQAGTHTAWKVRGRPQDGPKGD 220 A+ QQA A+ + +LV + D+ A++V R G+ Sbjct: 137 AISIQQAEMIAKQDVADRVTKERPAAEEGKPTRLVIYPDEETPRLAYEVNVRFLTPVPGN 196 Query: 221 WELLIDSGSGEVLRAEDKAFYA-TDGTGFVFRPDPLSPTKSSYGSTGYKDSSDADSTQLT 279 W +ID+ G+VL ++ A G V + + G Y + T + Sbjct: 197 WIYMIDAADGKVLNKWNQMDEAKPGGAQPVAGTSTVGVGRGVLGDQKYIN------TTYS 250 Query: 280 AARVRVTLKELAQSGTRYTLTGPYAACIDFDAPLDKACP----SQSTPAFEFTRGNLYFE 335 + L++ + +T +D P + F + Sbjct: 251 SYYGYYYLQDNTRGSGIFT----------YDGRNRTVLPGSLWADGDNQFF---ASYDAA 297 Query: 336 AVNAYYH---IDTFLRYVNQTLGIKALPYQYTGGVQYDPHGESGDDNSSYSSSSGRLTFG 392 AV+A+Y+ + + + V+ L V Y G +N+ ++ S + +G Sbjct: 298 AVDAHYYAGVVYDYYKNVHGRLSYDGSNAAIRSTVHYG----RGYNNAFWNGSQ--MVYG 351 Query: 393 QGGVDD----AEDADVVIHELGHGIHDWVTNGGLSQQEG-LSEGTGD---YLAAAYSRDF 444 G + DVV HEL H + D+ + G ++E D L Y+ Sbjct: 352 DGDGQTFLPFSGGIDVVGHELTHAVTDYTAGLVYQNESGAINEAMSDIFGTLVEFYANRN 411 Query: 445 NQWSPSDAQYQWVYNWDG----HNEFWGGRVTNWNVGRTYAQARGAEIHTAGQY------ 494 W + Y D + G +++ T Q G +G Sbjct: 412 PDWEIGEDIYTPGVAGDALRSMSDPAKYGDPDHYSKRYTGTQDNGGVHTNSGIINKAAYL 471 Query: 495 ---WASCNLVARDAIGAQAMDKAFLKGLSM-TNSSTNQKAAAQAVLTAAAALGYS-STQL 549 V+ IG M K F + L ++N A + AAA L S S ++ Sbjct: 472 LSQGGVHYGVSVTGIGRDKMGKIFYRALVYYLTPTSNFSQLRAACVQAAADLYGSTSQEV 531 Query: 550 TAIGNAYN 557 ++ A+N Sbjct: 532 NSVKQAFN 539
>TCRTETA#Tetracycline resistance protein signature. Length = 399 Score = 33.3 bits (76), Expect = 0.002 Identities = 47/270 (17%), Positives = 95/270 (35%), Gaps = 14/270 (5%) Query: 70 MFALTLVVGQVADRYDRRRIATICQSVEALAAGVFLLGAVQGWLAAPAVYAL--AAIVGT 127 FA V+G ++DR+ RR + + S+ A ++ AP ++ L IV Sbjct: 56 QFACAPVLGALSDRFGRRPV--LLVSLAGAAVDYAIMAT------APFLWVLYIGRIVAG 107 Query: 128 ARAFESPSVSSLLPAVVPRSDLPRATALSTSANQAAQILGPAFGGLLYGIGAPVAFGTSV 187 + + + + R ++ + GP GGL+ G F + Sbjct: 108 ITGATGAVAGAYIADITDGDERARHFGFMSACFGFGMVAGPVLGGLMGGFSPHAPFFAAA 167 Query: 188 AAFAIAAMLSGTIPLRSAPPAREPVTLRSV--FSGIAFIRREPAILGALSLDLFAVLFGG 245 A + + + S R P+ ++ + + R + +++ L G Sbjct: 168 ALNGLNFLTGCFLLPESHKGERRPLRREALNPLASFRWARGMTVVAALMAVFFIMQLVGQ 227 Query: 246 A-TALLPIYARDILQVGPWGLG-ALRAAPAVGALAGTLWLTRFPLKGRPGRAMFGGVIAF 303 AL I+ D +G +L A + +LA + + RA+ G+IA Sbjct: 228 VPAALWVIFGEDRFHWDATTIGISLAAFGILHSLAQAMITGPVAARLGERRALMLGMIAD 287 Query: 304 GIATIVFGLSRHFALSLVALAALGASDVIS 333 G I+ + ++ + L + + Sbjct: 288 GTGYILLAFATRGWMAFPIMVLLASGGIGM 317
>ECOLNEIPORIN#E.coli/Neisseria porin superfamily signature. Length = 331 Score = 88.3 bits (219), Expect = 1e-21 Identities = 74/369 (20%), Positives = 125/369 (33%), Gaps = 67/369 (18%) Query: 24 AQSSVTLYGILDAGITYVNNTGGSHVVKFDDGVA-----YGNRFGLKGTEDLGGGLKAVF 78 A + VTLYG + AG+ + + G++ G KG EDLG GLKA++ Sbjct: 17 AMADVTLYGTIKAGVETSRSVAHNGAQAASVETGTGIVDLGSKIGFKGQEDLGNGLKAIW 76 Query: 79 TLESGFHLGNGQLGFGGAEFGRQAYVGLQNDWGTLSFGNQLDITNELVSIYNISAWGSGY 138 +E G RQ+++GL+ +G L G + L +I+ W S Sbjct: 77 QVEQ----KASIAGTDSGWGNRQSFIGLKGGFGKLRVGRLNSV---LKDTGDINPWDSKS 129 Query: 139 AIHQGDFDRFNGDRLPNSVKFLSNDLSGFKFGAMYSFGNVAGNFHRNSAWSAGASFTKGD 198 + RL SV++ S + +G Y+ + AG H + ++ AG ++ G Sbjct: 130 DYLGVNKIAEPEARL-ISVRYDSPEFAGLSGSVQYALNDNAG-RHNSESYHAGFNYKNGG 187 Query: 199 FSIGAAYTRLNNPNGIYAFDPYAMIGTHTFLGQQTVTVDPATGARTDLFANTPMDVDSQG 258 F + + Q+ V ++ R Sbjct: 188 FFVQYGGAYKRHHQ-----------------VQENVNIEKYQIHRL------------VS 218 Query: 259 TFGIGTSYTIGKLTLDANYSYTTIKGFGQSSHMQVYEGGGLYQF-----TPALSFIAGYQ 313 + Y + SH E + TP +S+ G++ Sbjct: 219 GYDNDALYASVAVQQQDAKLVE-----ENYSHNSQTEVAATLAYRFGNVTPRVSYAHGFK 273 Query: 314 HTRF---EGHHWNQGTAGLHYLLSKRTDIYISGDYLRASQGVDAVVGYSFTPSTTQTQAD 370 + + ++Q G Y SKRT +S +L+ +G T Sbjct: 274 GSFDATNYNNDYDQVVVGAEYDFSKRTSALVSAGWLQEGKGES---------KFVSTAGG 324 Query: 371 VRIGMRHSF 379 V G+RH F Sbjct: 325 V--GLRHKF 331
>TCRTETA#Tetracycline resistance protein signature. Length = 399 Score = 30.2 bits (68), Expect = 0.015 Identities = 41/220 (18%), Positives = 67/220 (30%), Gaps = 7/220 (3%) Query: 158 VYNVGRMVGPTIAGFVYPTLGPRTSFAIYAL--ALCFMAACVRSIRTATVDRPSRAESGL 215 + G + GP + G + P F A L F+ C + +R L Sbjct: 139 CFGFGMVAGPVLGGLM-GGFSPHAPFFAAAALNGLNFLTGCFLLPESHKGERRPLRREAL 197 Query: 216 RDAVGYVLSDAFS--ARYLPILACIGLFAGSYQTLVPLLADQGFHDAARFTGVFFACAGA 273 + + + A + + + L L + + FH A G+ A G Sbjct: 198 NPLASFRWARGMTVVAALMAVFFIMQLVGQVPAALWVIFGEDRFHWDATTIGISLAAFGI 257 Query: 274 GSLSAAVLLSSAFGPRAS-RRFIAYAPWTAVGALAVLAATTDAAGSIPAFYALGFSLTFA 332 A +++ R RR + +LA T + P L Sbjct: 258 LHSLAQAMITGPVAARLGERRALMLGMIADGTGYILLAFATRGWMAFPIMVLLASG-GIG 316 Query: 333 ATSTNATIQRQCPEHVRGGLVGMYGMAYNGTMPFGYLLVG 372 + A + RQ E +G L G + T G LL Sbjct: 317 MPALQAMLSRQVDEERQGQLQGSLAALTSLTSIVGPLLFT 356
>TCRTETA#Tetracycline resistance protein signature. Length = 399 Score = 34.0 bits (78), Expect = 0.001 Identities = 63/364 (17%), Positives = 111/364 (30%), Gaps = 36/364 (9%) Query: 53 LPTLALQFGLN---KAQLGMFTSVTAAGQIIGGILFGFVSDRIGRVRTALLCVGIYSLFS 109 LP L + A G+ ++ A Q + G +SDR GR L+ + ++ Sbjct: 28 LPGLLRDLVHSNDVTAHYGILLALYALMQFACAPVLGALSDRFGRRPVLLVSLAGAAVDY 87 Query: 110 GLIAFAPDAHAFATLRFFGALGMGGTWTAGAALIAETWHPGRRGKGGALMQMGLPIGAIL 169 ++A AP R + G T A IA+ R + M G + Sbjct: 88 AIMATAPFLWVLYIGRIVAGI-TGATGAVAGAYIADITDGDERARHFGFMSACFGFGMVA 146 Query: 170 AIAISGIVGATHGGLGGDSWRLLFLIGASPFFILFWVARKTPESPIWLERRHAKPQARKP 229 + G+ +GG S F A+ + F ERR + +A P Sbjct: 147 GPVLGGL-------MGGFSPHAPFFAAAALNGLNFLTGCFLLPESHKGERRPLRREALNP 199 Query: 230 DTAGHEKLNVRGLLTAFCFIFFLQYLYWGV------------FTWTPTFLITVKHLDFVH 277 + + + A +FF+ L V F W T + Sbjct: 200 LASFRWARGMTV-VAALMAVFFIMQLVGQVPAALWVIFGEDRFHWDATTI---------- 248 Query: 278 SLKFVLALQFGAITGFLLFSAWVDRLGRRPMFLAYLVVGALAVGVYIVSANPLLLMTAIF 337 + ++ ++ RLG R + ++ + + + + Sbjct: 249 GISLAAFGILHSLAQAMITGPVAARLGERRALMLGMIADGTGYILLAFATRGWMAFPIMV 308 Query: 338 LTGFSVNGIFAGAGPFLAEIIGNTASRGFFMGLAYNGGRLGGFIAPLIIGALASTSGGFV 397 L GI A + + +G G L + PL+ A+ + S Sbjct: 309 LLASG--GIGMPALQAMLSRQVDEERQGQLQGSLAALTSLTSIVGPLLFTAIYAASITTW 366 Query: 398 LGLA 401 G A Sbjct: 367 NGWA 370 Score = 32.9 bits (75), Expect = 0.003 Identities = 29/129 (22%), Positives = 48/129 (37%), Gaps = 7/129 (5%) Query: 298 AWVDRLGRRPMFLAYLVVGALAVGVYIVSANPLLLMTAIFLTGFSVNGIFAGAGPFLAEI 357 A DR GRRP+ L L A+ + + +L + G + A AG ++A+I Sbjct: 65 ALSDRFGRRPVLLVSLAGAAVDYAIMATAPFLWVLYIGRIVAGIT-GATGAVAGAYIADI 123 Query: 358 I-GNTASRGF-FMGLAYNGGRLGGFIAPLIIGALASTSGGFVLGLATTIVAFVAAAAVVL 415 G+ +R F FM + G +A ++G L A + + Sbjct: 124 TDGDERARHFGFMSACFG----FGMVAGPVLGGLMGGFSPHAPFFAAAALNGLNFLTGCF 179 Query: 416 FAPETRGKT 424 PE+ Sbjct: 180 LLPESHKGE 188
>ECOLNEIPORIN#E.coli/Neisseria porin superfamily signature. Length = 331 Score = 66.7 bits (163), Expect = 2e-14 Identities = 81/365 (22%), Positives = 126/365 (34%), Gaps = 66/365 (18%) Query: 35 AQSSVTLYGIADVGVEHVNNTNTGGAQTRE----ASGNLSGSRWGLKGVEDLGGGMKAIF 90 A + VTLYG GVE + GAQ GS+ G KG EDLG G+KAI+ Sbjct: 17 AMADVTLYGTIKAGVETSRSVAHNGAQAASVETGTGIVDLGSKIGFKGQEDLGNGLKAIW 76 Query: 91 QLENGFNINDGTTAQSTKGLGSNAATTSRIFGRQAWVGLAYRGQQLTFGRQNALFYEQAV 150 Q+E +I + RQ+++GL +L GR N++ + Sbjct: 77 QVEQKASIAGTDSGWGN---------------RQSFIGLKGGFGKLRVGRLNSVLKD--- 118 Query: 151 AFDPMGASSRYSVLSVDYAAAARIDN---SVKYTG-VFGPLTAQAMYSTRYDTGYGAEVP 206 D S+ L V+ A + SV+Y F L+ Y+ + G Sbjct: 119 TGDINPWDSKSDYLGVNK--IAEPEARLISVRYDSPEFAGLSGSVQYALNDNAGRH---- 172 Query: 207 GAQLTGRFFSAALTFSQGPLAASVSYEQRNSNTVATNTGTERRATAAASYAIGPVKGFAG 266 + A + G + + V N E+ + + +G Sbjct: 173 ----NSESYHAGFNYKNGGFFVQYGGAYKRHHQVQENVNIEK----YQIHRLV-----SG 219 Query: 267 YRY--LRASNAFLPANPIRVANGAEASTANLYWAGAQYAVSPAFVVTATAYYQ----DVH 320 Y L AS A + V ++ A A V +Y Sbjct: 220 YDNDALYASVAVQQQDAKLVEENYSHNSQTE--VAATLAYRFGNVTPRVSYAHGFKGSFD 277 Query: 321 STSADPWL--AVLCADYLLSKRTDIYATAGFARNKGGSALGVNGYGTVAPDHNQTGVVIG 378 +T+ + V+ A+Y SKRT +AG+ + G + V T +G Sbjct: 278 ATNYNNDYDQVVVGAEYDFSKRTSALVSAGWLQEGKGESKFV-----------STAGGVG 326 Query: 379 MRQKF 383 +R KF Sbjct: 327 LRHKF 331
>TCRTETB#Tetracycline resistance protein TetB signature. Length = 458 Score = 37.9 bits (88), Expect = 6e-05 Identities = 33/182 (18%), Positives = 69/182 (37%), Gaps = 8/182 (4%) Query: 258 STLRDAMTNWRVFVLAFVNFCGIVGSLGVGLWMPQIIKQFGVEHAVVGWLTAIPYAIGAG 317 S LR N + L ++F ++ + + + +P I F A W+ + Sbjct: 8 SNLRH---NQILIWLCILSFFSVLNEMVLNVSLPDIANDFNKPPASTNWVNTAFMLTFSI 64 Query: 318 AMLWWARLANRAANRIPYVAGALALAAAALCASAFIHAPVFKLI-ALCVTVSGILAFQAT 376 + +L+++ + + G + ++ H+ LI A + +G AF A Sbjct: 65 GTAVYGKLSDQLGIKRLLLFGIIINCFGSVIG-FVGHSFFSLLIMARFIQGAGAAAFPAL 123 Query: 377 YWAIPSGFLTGRAAAGGLALIVSVGNLGGFVGPSMIGALKQFSGG---FTAPLIAVSGVL 433 + + ++ LI S+ +G VGP++ G + + P+I + V Sbjct: 124 VMVVVARYIPKENRGKAFGLIGSIVAMGEGVGPAIGGMIAHYIHWSYLLLIPMITIITVP 183 Query: 434 LL 435 L Sbjct: 184 FL 185
>HTHTETR#TetR bacterial regulatory protein HTH signature. Length = 215 Score = 80.8 bits (199), Expect = 5e-21 Identities = 33/194 (17%), Positives = 62/194 (31%), Gaps = 1/194 (0%) Query: 14 PPKQHDDLVATRDMLLRTGLEILTEKGFSATGLDEILGRAGVPKGSFYHYFDSKEAFGLK 73 K + TR +L L + +++G S+T L EI AGV +G+ Y +F K + Sbjct: 2 ARKTKQEAQETRQHILDVALRLFSQQGVSSTSLGEIAKAAGVTRGAIYWHFKDKSDLFSE 61 Query: 74 LIDRYAEFFARKLDRHFSQLERSPLARVRAFVDDARDGMARHAYNRGCL-IGNLGQEMGT 132 + + + ++ PL+ +R + + R + I E Sbjct: 62 IWELSESNIGELELEYQAKFPGDPLSVLREILIHVLESTVTEERRRLLMEIIFHKCEFVG 121 Query: 133 LPESFRARLRATFEDWQRRLAECLDAAQQAGELAESADPAALAAFFWIGWEGAVLRAKLE 192 + R + R+ + L +A L A G + Sbjct: 122 EMAVVQQAQRNLCLESYDRIEQTLKHCIEAKMLPADLMTRRAAIIMRGYISGLMENWLFA 181 Query: 193 RSDQPLALFAQFFF 206 L A+ + Sbjct: 182 PQSFDLKKEARDYV 195
>NUCEPIMERASE#Nucleotide sugar epimerase signature. Length = 334 Score = 33.6 bits (77), Expect = 8e-04 Identities = 15/53 (28%), Positives = 24/53 (45%) Query: 151 IVVTGAAGGVGSVATALLARLGYRVVAVTGRPADADYLRQLGAAEILDRAQFS 203 +VTGAAG +G + L G++VV + D + E+L + F Sbjct: 3 YLVTGAAGFIGFHVSKRLLEAGHQVVGIDNLNDYYDVSLKQARLELLAQPGFQ 55
>DHBDHDRGNASE#2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase signature. Length = 261 Score = 99.0 bits (246), Expect = 1e-26 Identities = 51/188 (27%), Positives = 84/188 (44%), Gaps = 9/188 (4%) Query: 3 KVWLVTGAARGLGRAISEAVLAAGDRLVAGARDPARLADLAE------RYGDRLLPVELD 56 K+ +TGAA+G+G A++ + + G + A +P +L + R+ + D Sbjct: 9 KIAFITGAAQGIGEAVARTLASQGAHIAAVDYNPEKLEKVVSSLKAEARHAEAF---PAD 65 Query: 57 VTDEAAAAQAVSAARAAFGRIDVLVNNAGYGHTAPFEQMSADAFRDQIETNLFGVINLTR 116 V D AA + + G ID+LVN AG +S + + N GV N +R Sbjct: 66 VRDSAAIDEITARIEREMGPIDILVNVAGVLRPGLIHSLSDEEWEATFSVNSTGVFNASR 125 Query: 117 AVLPTMRAQRAGHIFQVSSVGGRTSTPGLSAYQAAKWAVGGFSDVLAKEAAPFGVRVCTL 176 +V M +R+G I V S ++AY ++K A F+ L E A + +R + Sbjct: 126 SVSKYMMDRRSGSIVTVGSNPAGVPRTSMAAYASSKAAAVMFTKCLGLELAEYNIRCNIV 185 Query: 177 EPGGMRTE 184 PG T+ Sbjct: 186 SPGSTETD 193
>HTHTETR#TetR bacterial regulatory protein HTH signature. Length = 215 Score = 48.5 bits (115), Expect = 2e-09 Identities = 35/189 (18%), Positives = 67/189 (35%), Gaps = 10/189 (5%) Query: 3 RPRSPDKHDAILAAAARALAEDGASATTAR-IAKLAGVAEGTVFTYFETKDALLNALYLS 61 + + + IL A R ++ G S+T+ IAK AGV G ++ +F+ K L + ++ Sbjct: 6 KQEAQETRQHILDVALRLFSQQGVSSTSLGEIAKAAGVTRGAIYWHFKDKSDLFSEIWEL 65 Query: 62 LKAGLREAMMTGFPE-HAPAEQAVRHAWNGYVSWGVANPDGRRAL-------QQLGVSGR 113 ++ + E + + +R + V R + + +G Sbjct: 66 SESNIGELELEYQAKFPGDPLSVLREILIHVLESTVTEERRRLLMEIIFHKCEFVGEMAV 125 Query: 114 IDDAHRAAGAEGFGGIGSLLREQVGASGTLNRDEAHAFCSALFTSIAETAMESIARDPAR 173 + A R E + I L+ + A + I+ ME+ P Sbjct: 126 VQQAQRNLCLESYDRIEQTLKHCIEAKMLPADLMTRRAAIIMRGYISGL-MENWLFAPQS 184 Query: 174 ADAYREAGF 182 D +EA Sbjct: 185 FDLKKEARD 193
>NUCEPIMERASE#Nucleotide sugar epimerase signature. Length = 334 Score = 44.4 bits (105), Expect = 5e-07 Identities = 60/320 (18%), Positives = 103/320 (32%), Gaps = 76/320 (23%) Query: 187 LVTGGTGFIGETLVNQLLDAGQTVTLL---------ARDPLRAAYL-------FQGRVRS 230 LVTG GFIG + +LL+AG V + + R L + + Sbjct: 4 LVTGAAGFIGFHVSKRLLEAGHQVVGIDNLNDYYDVSLKQARLELLAQPGFQFHKIDLAD 63 Query: 231 VTSIDQLQPHERFDTVVNLAGAPVLGARWSKRRQALLLASRVGVTQALMRWVETAEVKPR 290 + L F+ V L R+S S + ++ +++ Sbjct: 64 REGMTDLFASGHFERVFISPHR--LAVRYSLENPHAYADSNLTGFLNILEGCRHNKIQHL 121 Query: 291 TWIQASAIGYYGVRPG-----DERLDEGSS--AGTGFMSDLCRRWEAAAEPL-----ERH 338 + +S++ YG+ D+ +D S A T + A E + + Sbjct: 122 LYASSSSV--YGLNRKMPFSTDDSVDHPVSLYAAT----------KKANELMAHTYSHLY 169 Query: 339 GVRAVVLRLGIVFGPGGALRPMLLPHYFG---LGGR----FGDGAQVMSWIHRDDVLRIV 391 G+ A LR V+GP G RP + F L G+ + G + + DD+ + Sbjct: 170 GLPATGLRFFTVYGPWG--RPDMALFKFTKAMLEGKSIDVYNYGKMKRDFTYIDDIAEAI 227 Query: 392 ARAMSNP------------------GMHGVYN--AVAPVPLTQRAFVQVVTKVLRRPA-- 429 R + VYN +PV L ++Q + L A Sbjct: 228 IRLQDVIPHADTQWTVETGTPAASIAPYRVYNIGNSSPVELMD--YIQALEDALGIEAKK 285 Query: 430 -FLHMPAAPLRAAMGEMAEL 448 L + + + L Sbjct: 286 NMLPLQPGDVLETSADTKAL 305
>NUCEPIMERASE#Nucleotide sugar epimerase signature. Length = 334 Score = 44.8 bits (106), Expect = 4e-07 Identities = 62/292 (21%), Positives = 100/292 (34%), Gaps = 62/292 (21%) Query: 20 TVLVCGANGFIGRALCAQLEAGGHRVLRGVRHAAGPYDVAIDFAH--------------D 65 LV GA GFIG + +L GH+V+ G+ + YDV++ A D Sbjct: 2 KYLVTGAAGFIGFHVSKRLLEAGHQVV-GIDNLNDYYDVSLKQARLELLAQPGFQFHKID 60 Query: 66 VDPHAWLARL---KGVDVVINAVGMLADRR----GATLDAVHRAAPSALFTACCRAGVRR 118 + + L + V + LA R + + C ++ Sbjct: 61 LADREGMTDLFASGHFERVFISPHRLAVRYSLENPHAYADSNLTGFLNILEGCRHNKIQH 120 Query: 119 VIQISALGVERGDTR----------------YFASKQAADRFLQTLP----IDFRIVRPA 158 ++ S+ V G R Y A+K+A + T + +R Sbjct: 121 LLYASSSSV-YGLNRKMPFSTDDSVDHPVSLYAATKKANELMAHTYSHLYGLPATGLRFF 179 Query: 159 LVYGAAG----ASARFFR-MLASLPVHVLPAGGHQRLRPVHVDDLAEVVARLVMQPSDSP 213 VYG G A +F + ML + V G +R ++DD+AE + RL + Sbjct: 180 TVYGPWGRPDMALFKFTKAMLEGKSIDVYNYGKMKR-DFTYIDDIAEAIIRLQDVIPHAD 238 Query: 214 PARAR------------RVIDVVGRDEVEYREMLAAYRAALGFPPAARVTLP 253 RV ++ VE + + A ALG A + LP Sbjct: 239 TQWTVETGTPAASIAPYRVYNIGNSSPVELMDYIQALEDALG-IEAKKNMLP 289
>ENTEROTOXINA#Heat-labile enterotoxin A chain signature. Length = 258 Score = 26.5 bits (58), Expect = 0.025 Identities = 17/57 (29%), Positives = 23/57 (40%), Gaps = 10/57 (17%) Query: 43 LGRFHERLVGPHPAWSYQIAFDAARFDDIVPWLVLNHGALDIFLHPNTHDELRDHRD 99 LG + PHP A + I W +N G +D LH N R++RD Sbjct: 119 LGVY-----SPHPYEQEVSALGGIPYSQIYGWYRVNFGVIDERLHRN-----REYRD 165
>TCRTETB#Tetracycline resistance protein TetB signature. Length = 458 Score = 130 bits (329), Expect = 2e-35 Identities = 81/404 (20%), Positives = 154/404 (38%), Gaps = 14/404 (3%) Query: 13 RVLAATCVSYMLVLLDASIVNVALTDIAHTFGSRVAGLQWIVNAYTLAFASLLLTGGTLG 72 ++L C+ +L+ ++NV+L DIA+ F A W+ A+ L F+ G L Sbjct: 14 QILIWLCILSFFSVLNEMVLNVSLPDIANDFNKPPASTNWVNTAFMLTFSIGTAVYGKLS 73 Query: 73 DRLGDRTVYVAGLAVFVAASALCGVAPT-LPALAVARALQGVGSAMLVPCSLALINRAFP 131 D+LG + + + G+ + S + V + L +AR +QG G+A P + ++ + Sbjct: 74 DQLGIKRLLLFGIIINCFGSVIGFVGHSFFSLLIMARFIQGAGAAAF-PALVMVVVARYI 132 Query: 132 EPAARASAISVWMGCGGIAMASGPLIGGLLIDLSGWRSLFFVNLPLGLAGIWLGRTVAPA 191 R A + + GP IGG++ W L + + + + + + Sbjct: 133 PKENRGKAFGLIGSIVAMGEGVGPAIGGMIAHYIHWSYLLLIPM-ITIITVPFLMKLLKK 191 Query: 192 AVDRSRQFDWGGQAAAIVAIGALIGTLIEGPSLGWRSAPIVGGAMASVVAWIAFIAIEAR 251 V FD G I+ + I + + S IV SV++++ F+ + Sbjct: 192 EVRIKGHFDIKG----IILMSVGIVFFMLFTTSYSISFLIV-----SVLSFLIFVKHIRK 242 Query: 252 RRAPMLPLAFFRNRLFAGSTFVSMASAFVFYGLLFVLSLFYRQVRGASPLDTGLAFL-PM 310 P + +N F G + ++ + V S + G + P Sbjct: 243 VTDPFVDPGLGKNIPFMIGVLCGGIIFGTVAGFVSMVPYMMKDVHQLSTAEIGSVIIFPG 302 Query: 311 TAMVALGGLTSGRVVARFGARGTMCAAFGLYAAGALGITAIGATTPAWLAVAPMLAIGFA 370 T V + G G +V R G + + L + + TT ++ + + +G Sbjct: 303 TMSVIIFGYIGGILVDRRGPLYVLNIGVTFLSVSFLTASFLLETTSWFMTIIIVFVLGGL 362 Query: 371 SGFISPAATAPALGTIDRPRAGVAAAVLNAARQSGSALGVAIFG 414 S F + ++ + AG ++LN G+AI G Sbjct: 363 S-FTKTVISTIVSSSLKQQEAGAGMSLLNFTSFLSEGTGIAIVG 405
>TONBPROTEIN#Gram-negative bacterial tonB protein signature. Length = 239 Score = 30.7 bits (69), Expect = 0.011 Identities = 22/131 (16%), Positives = 40/131 (30%), Gaps = 6/131 (4%) Query: 361 AGASGVAVSLVCADEAPQLAAIEALIRQTLRREEEPGFEAEHRVPETSATGEIIKKPKKP 420 A A ++V++V + A++ + E EP E + KPK Sbjct: 40 APAQPISVTMVTPADLEPPQAVQPPPEPVVEPEPEPEPIPEPPKEAPVVIEKPKPKPKPK 99 Query: 421 KKPKVQQAAPVGRQAQPGKKPP-----TQGGEGKRKPVAQHAKPAVGTGTDYTIGSPFSV 475 KP + R +P + P A A + + + S Sbjct: 100 PKPVKKVQEQPKRDVKPVESRPASPFENTAPARLTSSTAT-AATSKPVTSVASGPRALSR 158 Query: 476 QKPRSKPAGKA 486 +P+ +A Sbjct: 159 NQPQYPARAQA 169
>PF06580#Sensor histidine kinase Length = 349 Score = 37.9 bits (88), Expect = 6e-05 Identities = 17/62 (27%), Positives = 28/62 (45%), Gaps = 6/62 (9%) Query: 417 HTVTLTIADNGCGFDAERSQADVRHGIGLRNMRERLDALGG---TLTITSQVGHTIVAAS 473 TVTL + + G ++ G GL+N+RERL L G + ++ + G Sbjct: 290 GTVTLEVENTGSLALKNTKES---TGTGLQNVRERLQMLYGTEAQIKLSEKQGKVNAMVL 346 Query: 474 VP 475 +P Sbjct: 347 IP 348
>HTHFIS#FIS bacterial regulatory protein HTH signature. Length = 484 Score = 70.6 bits (173), Expect = 1e-16 Identities = 33/120 (27%), Positives = 48/120 (40%), Gaps = 1/120 (0%) Query: 9 PAARLLLVDDHPLVRDGLRMRLEAADLSVVGEAGNADEALALAESLEPDLALMDVGMNGM 68 A +L+ DD +R L L A V NA + + DL + DV M Sbjct: 2 TGATILVADDDAAIRTVLNQALSRAGYDVRI-TSNAATLWRWIAAGDGDLVVTDVVMPDE 60 Query: 69 NGITLAGVFHERFPGIRVLMLSMHDNIEYVTQAVRAGASGYLLKDSPASEIVRAIGAVLA 128 N L + P + VL++S + +A GA YL K +E++ IG LA Sbjct: 61 NAFDLLPRIKKARPDLPVLVMSAQNTFMTAIKASEKGAYDYLPKPFDLTELIGIIGRALA 120
>TCRTETB#Tetracycline resistance protein TetB signature. Length = 458 Score = 130 bits (328), Expect = 4e-35 Identities = 86/432 (19%), Positives = 167/432 (38%), Gaps = 15/432 (3%) Query: 2 SRYRRAALVLAACLGTFLATLDISIVNVALPTLQTALDTDIGGLQWVVNAYALALSAFML 61 S R +++ C+ +F + L+ ++NV+LP + + WV A+ L S Sbjct: 8 SNLRHNQILIWLCILSFFSVLNEMVLNVSLPDIANDFNKPPASTNWVNTAFMLTFSIGTA 67 Query: 62 SAGPLGDRYGHKRVWLASVILFTAGSIVCACAGRIEPLL-AGRAIQGLAGALLIPGAMPI 120 G L D+ G KR+ L +I+ GS++ LL R IQG AGA P + + Sbjct: 68 VYGKLSDQLGIKRLLLFGIIINCFGSVIGFVGHSFFSLLIMARFIQG-AGAAAFPALVMV 126 Query: 121 LTHAFPDARERARVIGGWSAFSALALIVGPLLGGLLVEHGGWQDIFLVNVPIGIVAVLLG 180 + + R + G + A+ VGP +GG++ + W + L+ + I L Sbjct: 127 VVARYIPKENRGKAFGLIGSIVAMGEGVGPAIGGMIAHYIHWSYLLLIPMITIITVPFLM 186 Query: 181 AWGIPERRHPEHAAFDPFGQVLSVAWLGLLTYGLIGIGEAGTSHVKVLAPLAGAAVAFVV 240 E R H FD G +L + TS+ + + ++F++ Sbjct: 187 KLLKKEVRIKGH--FDIKGIILMSVGIVFFMLFT-------TSYSISFLIV--SVLSFLI 235 Query: 241 FVRVETRVARPLLPVWLFRDRRLVRANLASFVLGFSGYSSLFFLSLFLQQAQGRAPAAAG 300 FV+ +V P + L ++ + L ++ + + + ++ + A G Sbjct: 236 FVKHIRKVTDPFVDPGLGKNIPFMIGVLCGGIIFGTVAGFVSMVPYMMKDVHQLSTAEIG 295 Query: 301 WQLM-PQFVMTAITSMLFGRIAARIPLRALMVAGYGLIGAMLAVMAGFGAATPYAALGVV 359 ++ P + I + G + R ++ G + + T + ++ Sbjct: 296 SVIIFPGTMSVIIFGYIGGILVDRRGPLYVLNIGVTFLSVSFLTASFLLETTSWFMTIII 355 Query: 360 LALLGVGMGLAVPATGMTVMELAPAERAGMASATMNALRQTGMSLGIAVLGSMMSVGALH 419 + +LG + + L E AG + +N GIA++G ++S+ L Sbjct: 356 VFVLGGLSFTKTVISTIVSSSLKQQE-AGAGMSLLNFTSFLSEGTGIAIVGGLLSIPLLD 414 Query: 420 RMTVAMHVAGSA 431 + + M V S Sbjct: 415 QRLLPMEVDQST 426
>HTHTETR#TetR bacterial regulatory protein HTH signature. Length = 215 Score = 64.3 bits (156), Expect = 8e-15 Identities = 31/201 (15%), Positives = 73/201 (36%), Gaps = 13/201 (6%) Query: 20 KPRTKPAEVRLEELMAAAETLFLAQGVEATTISEIVEHAQVAKGTFYHYFESKADMLAAL 79 + + A+ + ++ A LF QGV +T++ EI + A V +G Y +F+ K+D+ + + Sbjct: 3 RKTKQEAQETRQHILDVALRLFSQQGVSSTSLGEIAKAAGVTRGAIYWHFKDKSDLFSEI 62 Query: 80 AQRYTASFLDQLQHAVNGCDADDWLARLRAWIRASIE----------IYAATYRTHDIVY 129 + ++ + D + LR + +E + + + V Sbjct: 63 WELSESNIGELELEYQAKFPGDPL-SVLREILIHVLESTVTEERRRLLMEIIFHKCEFVG 121 Query: 130 TNHHHHDRENADKNAILEQLGAILDGGVRAGAWRLAHPP-VTALLIYAGVHGATDHIIAS 188 + +++ L + A A+++ + G ++ + + Sbjct: 122 EMAVVQQAQRNLCLESYDRIEQTLKHCIEAKMLPADLMTRRAAIIMRGYISGLMENWLFA 181 Query: 189 PET-DRAAFVDAVVDDCLRML 208 P++ D V L M Sbjct: 182 PQSFDLKKEARDYVAILLEMY 202
>ACRIFLAVINRP#Acriflavin resistance protein family signature. Length = 1034 Score = 58.3 bits (141), Expect = 1e-10 Identities = 49/205 (23%), Positives = 82/205 (40%), Gaps = 18/205 (8%) Query: 284 TLLAVLVILWLALRSKRMIGSVLVTLFVGLVVTAALGLAMVGSLNMISVAFMVLFVGLGV 343 +L LV+ L L++ R + + V L+ T A+ A S+N +++ MVL +GL V Sbjct: 348 IMLVFLVMY-LFLQNMRATLIPTIAVPVVLLGTFAILAAFGYSINTLTMFGMVLAIGLLV 406 Query: 344 DFSIQYGVKYREERFRDERID--HALIGAAHSMGMPLALATAAVAASFFSFIPTAYRGVS 401 D +I V+ E ++++ A + + L ++A FIP A+ G S Sbjct: 407 DDAIVV-VENVERVMMEDKLPPKEATEKSMSQIQGALVGIAMVLSA---VFIPMAFFGGS 462 Query: 402 E------LGLIAGVGMFVALLTTLTLLPALLRLF-----APPGESKTPGFPWLAPVDDYL 450 + M +++L L L PAL A E+K F W D+ Sbjct: 463 TGAIYRQFSITIVSAMALSVLVALILTPALCATLLKPVSAEHHENKGGFFGWFNTTFDHS 522 Query: 451 DRHRKPILIGTLAVVIGALPLLAFL 475 H + L L + A + Sbjct: 523 VNHYTNSVGKILGSTGRYLLIYALI 547 Score = 31.7 bits (72), Expect = 0.013 Identities = 31/182 (17%), Positives = 63/182 (34%), Gaps = 36/182 (19%) Query: 268 DEFASVEDGAALNGVLTLLAVLVILWLALRSKRMIGSVLVTLFVGLVVTAALGLAMVGSL 327 + + A ++ + V + L S + SV++ + +G+V L + Sbjct: 863 YQERLSGNQAPALVAISFVVVFLCLAALYESWSIPVSVMLVVPLGIV-GVLLAATLFNQ- 920 Query: 328 NMISVAFMVLFVGLG----------VDFSIQYGVKYREERFRDERIDHA---------LI 368 V FMV + V+F+ + +E + E A + Sbjct: 921 -KNDVYFMVGLLTTIGLSAKNAILIVEFAKD--LMEKEGKGVVEATLMAVRMRLRPILMT 977 Query: 369 GAAHSMGM-PLALATAAVAASFFSFIPTAYRGVSELGLIAGVGMFVALLTTLTLLPALLR 427 A +G+ PLA++ A + + + G+ +G GM A L + +P Sbjct: 978 SLAFILGVLPLAISNGAGSGAQNAV------GIGVMG-----GMVSATLLAIFFVPVFFV 1026 Query: 428 LF 429 + Sbjct: 1027 VI 1028
>VACJLIPOPROT#VacJ lipoprotein signature. Length = 251 Score = 217 bits (555), Expect = 8e-72 Identities = 75/238 (31%), Positives = 117/238 (49%), Gaps = 8/238 (3%) Query: 3 KVRIIAATVAASAVLTGCATGP--NRNPNDPLEPMNRAMYKFN-DTVDTNIAQPIAKGYQ 59 K+R+ A + + +L GCA+ + +DPLE NR MY FN + +D I +P+A ++ Sbjct: 2 KLRLSALALGTT-LLVGCASSGTDQQGRSDPLEGFNRTMYNFNFNVLDPYIVRPVAVAWR 60 Query: 60 KVTPTPVRTAISNFFSNLGDLGNMANNLLQLRITDATQDLMRVAMNSLFGVAGLIDIATP 119 P P R +SNF NL + M N LQ R +N++ G+ G ID+A Sbjct: 61 DYVPQPARNGLSNFTGNLEEPAVMVNYFLQGDPYQGMVHFTRFFLNTILGMGGFIDVAGM 120 Query: 120 AGLPKH---HQDFGLTMARWGMPSGPYLVLPVFGPSTIRDGVGRAVDVRFNLLNYIEPAA 176 A FG T+ +G+ GPY+ LP +G T+RD G D + +L+++ Sbjct: 121 ANPKLQRTEPHRFGSTLGHYGVGYGPYVQLPFYGSFTLRDDGGDMADALYPVLSWLTWPM 180 Query: 177 RNPMYIAQFISARSDLLGATDLLKQAALDPYSFVRDAYLQQRKSLTYHGQSASAAAPN 234 + + I R+ LL + LL+Q + DPY VR+AY Q+ + G+ PN Sbjct: 181 SVGKWTLEGIETRAQLLDSDGLLRQ-SSDPYIMVREAYFQRHDFIANGGELKPQENPN 237
>TCRTETA#Tetracycline resistance protein signature. Length = 399 Score = 58.3 bits (141), Expect = 2e-11 Identities = 63/356 (17%), Positives = 114/356 (32%), Gaps = 38/356 (10%) Query: 39 ELGLSNT---ELGVAFSAFAYSYAICQIGGGWIADRFGARITLIGCGLIWVVATFTTGLV 95 +L SN G+ + +A C G ++DRFG R L+ V Sbjct: 34 DLVHSNDVTAHYGILLALYALMQFACAPVLGALSDRFGRRPVLLVSLAGAAVDYAIMATA 93 Query: 96 HSLGLLFAARLLLGIGEGATLPAQARAVTHWFPRERRGVVQGFTHSFSRLGNA-----VT 150 L +L+ R++ GI GAT + + R F + V Sbjct: 94 PFLWVLYIGRIVAGI-TGATGAVAGAYIADITDGDER------ARHFGFMSACFGFGMVA 146 Query: 151 PPIVAALMTWLSWRAAFFVIGAVTLVWLAWWIVGFREHPAGDDDGRTRTARPAAPSGPTP 210 P++ LM S A FF A+ + E G+ R A P Sbjct: 147 GPVLGGLMGGFSPHAPFFAAAALNGLNFLTGCFLLPESHKGERRPLRREA--LNPLASFR 204 Query: 211 WGPLFRRMAPTIFVYFC------YGWTAWLFFTWLPTFFLNGQGLNVKSTALFASGVFFA 264 W +A + V+F W+ F F + + + A Sbjct: 205 WARGMTVVAALMAVFFIMQLVGQVPAALWVIFG-EDRFHWDATTIGISLAAFGILHSLAQ 263 Query: 265 GVVGDTLGGWLCDRIYRKTGNLALSRQSVIVTSFVGALVCLLPLAFVHSTAGVALCLSGS 324 ++ + L +R G + I+ +F P+ + ++ G+ + + Sbjct: 264 AMITGPVAARLGERRALMLG-MIADGTGYILLAFATRGWMAFPIMVLLASGGIGMPALQA 322 Query: 325 FLSLELTIGPIWAVPSDIAPTHAGIASGMMNAGSAISGILSPILFGYLVDRT-GSW 379 LS + G G + A ++++ I+ P+LF + + +W Sbjct: 323 MLS------------RQVDEERQGQLQGSLAALTSLTSIVGPLLFTAIYAASITTW 366
>PF06580#Sensor histidine kinase Length = 349 Score = 38.7 bits (90), Expect = 3e-05 Identities = 16/71 (22%), Positives = 26/71 (36%), Gaps = 20/71 (28%) Query: 254 LLENARRHAV-----PGAIRIQTRIEDGMCRLRVEDDGPGIPAEFAPHVFQAFRRVDESQ 308 L+EN +H + G I ++ ++G L VE+ G ++ Sbjct: 263 LVENGIKHGIAQLPQGGKILLKGTKDNGTVTLEVENTGSLAL---------------KNT 307 Query: 309 PGGTGLGLAVV 319 TG GL V Sbjct: 308 KESTGTGLQNV 318
>HTHFIS#FIS bacterial regulatory protein HTH signature. Length = 484 Score = 81.0 bits (200), Expect = 8e-20 Identities = 31/137 (22%), Positives = 58/137 (42%), Gaps = 6/137 (4%) Query: 18 VLIAEDEPEIAEILTAYFARNGLRTVHAADGRRALELHLSLKPDLVLLDVQMPHVDGWKV 77 +L+A+D+ I +L +R G ++ + DLV+ DV MP + + + Sbjct: 6 ILVADDDAAIRTVLNQALSRAGYDVRITSNAATLWRWIAAGDGDLVVTDVVMPDENAFDL 65 Query: 78 LAEIR-HRGDTPVIMLTALDQDIDKLTGLRIGADDYVVKPFNPAEVVARAQAVLRRSMAG 136 L I+ R D PV++++A + + + GA DY+ KPF+ E++ L Sbjct: 66 LPRIKKARPDLPVLVMSAQNTFMTAIKASEKGAYDYLPKPFDLTELIGIIGRALAE---- 121 Query: 137 SRQEEQRVLRAAPFEID 153 + L + Sbjct: 122 -PKRRPSKLEDDSQDGM 137
>HTHTETR#TetR bacterial regulatory protein HTH signature. Length = 215 Score = 62.0 bits (150), Expect = 4e-14 Identities = 30/188 (15%), Positives = 61/188 (32%), Gaps = 7/188 (3%) Query: 8 RAERRDATRERLIDAARVIFAEKGYAAASVEDIAAAAGHTRGAFYSNFRGKADVLFELLG 67 + TR+ ++D A +F+++G ++ S+ +IA AAG TRGA Y +F+ K+D+ E+ Sbjct: 5 TKQEAQETRQHILDVALRLFSQQGVSSTSLGEIAKAAGVTRGAIYWHFKDKSDLFSEIWE 64 Query: 68 RDQDEAAAALQRIVGAHDPDDDAQ-----RAMLAYWRRGTTQPASRLMWLDAQLQAARDP 122 + D + +L + + Sbjct: 65 LSESNIGELELEYQAKFPGDPLSVLREILIHVLESTVTEERRRLLMEIIFHKCEFVGEMA 124 Query: 123 QFRARFGALLHDRRALAAACIDAYAARVGVSLPLPTQVLALGLTALCDGMHSHGAAEARP 182 + L + + + L T+ A+ + G+ + P Sbjct: 125 VVQQAQRNLCLESYDRIEQTLKHCIEAKMLPADLMTRRAAIIMRGYISGLMEN--WLFAP 182 Query: 183 TDDTLADT 190 L Sbjct: 183 QSFDLKKE 190
>TYPE4SSCAGX#Type IV secretion system CagX conjugation protein signature. Length = 522 Score = 27.1 bits (59), Expect = 0.024 Identities = 19/90 (21%), Positives = 43/90 (47%), Gaps = 1/90 (1%) Query: 32 EQAASAAASPRAAKKAERAADRAFAKKVRQAIVRAPGVGNAQ-VTVFAKAKTGDVTLAGQ 90 EQA A R +K ERA +RA + + A+ + N + ++ K + + + Sbjct: 156 EQAQKAQKDKREKRKEERAKNRANLENLTNAMSNPQNLSNNKNLSELIKQQRENELDQME 215 Query: 91 IADESQDRAAVDAARQVPGVTSVKSKLQLR 120 ++ Q++A +A +Q+ + +++ +R Sbjct: 216 RLEDMQEQAQANALKQIEELNKKQAEEAVR 245
>PF06580#Sensor histidine kinase Length = 349 Score = 29.4 bits (66), Expect = 4e-04 Identities = 10/46 (21%), Positives = 23/46 (50%) Query: 1 MLGTILIIVLILLLIGAFPAWPHSRSWGYWPSGTVGLIVVIVVILV 46 M+ I I ++ L+L A+ ++ + W G + L V+ +++ Sbjct: 42 MIFNIAISLMGLVLTHAYRSFIKRQGWLKLNMGQIILRVLPACVVI 87
>DHBDHDRGNASE#2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase signature. Length = 261 Score = 124 bits (313), Expect = 8e-37 Identities = 87/255 (34%), Positives = 121/255 (47%), Gaps = 9/255 (3%) Query: 8 LTGKIALVTGASRGIGEEIAKLLAEQGAYVIVSSRKLDDCQAVADAIVAAGGRAEALACH 67 + GKIA +TGA++GIGE +A+ LA QGA++ + + V ++ A AEA Sbjct: 6 IEGKIAFITGAAQGIGEAVARTLASQGAHIAAVDYNPEKLEKVVSSLKAEARHAEAFPAD 65 Query: 68 VGRLEDIAATFEHIRGKHGRLDILVNNAAANPYFGHILDTDLAAYEKTVDVNIRGYFFMS 127 V I I + G +DILVN A G I +E T VN G F S Sbjct: 66 VRDSAAIDEITARIEREMGPIDILVN-VAGVLRPGLIHSLSDEEWEATFSVNSTGVFNAS 124 Query: 128 VEAGKLMKTHGGGAIVNTASVNALQPGDWQGIYSITKAAVVNMTKAFAKECGPLGIRVNA 187 K M G+IV S A P Y+ +KAA V TK E IR N Sbjct: 125 RSVSKYMMDRRSGSIVTVGSNPAGVPRTSMAAYASSKAAAVMFTKCLGLELAEYNIRCNI 184 Query: 188 LLPGLTKTKFAGALFADKD--------IYETWMTKIPLRRHAEPREMAGTVLYLVSDAAS 239 + PG T+T +L+AD++ ET+ T IPL++ A+P ++A VL+LVS A Sbjct: 185 VSPGSTETDMQWSLWADENGAEQVIKGSLETFKTGIPLKKLAKPSDIADAVLFLVSGQAG 244 Query: 240 YTNGECIVVDGGLTI 254 + + VDGG T+ Sbjct: 245 HITMHNLCVDGGATL 259
>DHBDHDRGNASE#2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase signature. Length = 261 Score = 112 bits (281), Expect = 4e-32 Identities = 81/259 (31%), Positives = 121/259 (46%), Gaps = 10/259 (3%) Query: 1 MKLDSYAGQAVMITGAASGFGALLASELAAMGARLALGDLNGDALERVAAPLRAAGADVI 60 M G+ ITGAA G G +A LA+ GA +A D N + LE+V + L+A Sbjct: 1 MNAKGIEGKIAFITGAAQGIGEAVARTLASQGAHIAAVDYNPEKLEKVVSSLKAEARHAE 60 Query: 61 AQRCDVRVETEVAALVQEAVARFGRLDVGINNAGIAPPMKALIDTDEADLDLNFAVNAKG 120 A DVR + + G +D+ +N AG+ P + + + + F+VN+ G Sbjct: 61 AFPADVRDSAAIDEITARIEREMGPIDILVNVAGVLRP-GLIHSLSDEEWEATFSVNSTG 119 Query: 121 VFFGMKHQIRQMLAQREGVILNVASMAGLGGAPKLAAYAASKHAVVGLTKTAALEYARHG 180 VF + + M+ +R G I+ V S +AAYA+SK A V TK LE A + Sbjct: 120 VFNASRSVSKYMMDRRSGSIVTVGSNPAGVPRTSMAAYASSKAAAVMFTKCLGLELAEYN 179 Query: 181 IRVNAVCPFYSTTPM---VTDSEIGERQ---DFLAQ---GSPMKRLGRPDEIVATMLMLC 231 IR N V P + T M + E G Q L G P+K+L +P +I +L L Sbjct: 180 IRCNIVSPGSTETDMQWSLWADENGAEQVIKGSLETFKTGIPLKKLAKPSDIADAVLFLV 239 Query: 232 AKDNTYLTGQAVAVDGGVS 250 + ++T + VDGG + Sbjct: 240 SGQAGHITMHNLCVDGGAT 258