PredictBias

		>SSBTLNINHBTR#Streptomyces subtilisin inhibitor signature.

		          Length = 144

		

		 Score = 30.2 bits (67), Expect = 0.011

		 Identities = 27/119 (22%), Positives = 46/119 (38%), Gaps = 15/119 (12%)

		

		Query: 87  GAPAGVAPAAP-RMPLTPNGPAAAVAAIAANLTAHASAAPSAPADVPLTPSAAAAHHLHG 145

		           G  AG + A+P   P +   P+A V  +    +A A+AAP     +   P+A+  H    

		Sbjct: 20  GPLAGASLASPATAPASLYAPSALVLTVGHGESA-ATAAPLRAVTLTCAPTASGTHPAAA 78

		

		Query: 146 DDADI------DLPSLPAHEAAAGRRTWRPGPGAAPANGAEADSMYERSKLNPVLTFDN 198

		                      D  +L A ++    R + P            D +++  +L+   TF N

		Sbjct: 79  AACAELRAAHGDPSALAAEDSVMCTREYAP-------VVVTVDGVWQGRRLSYERTFAN 130

		

		

		>HTHFIS#FIS bacterial regulatory protein HTH signature.

		          Length = 484

		

		 Score = 31.3 bits (71), Expect = 0.003

		 Identities = 34/170 (20%), Positives = 60/170 (35%), Gaps = 25/170 (14%)

		

		Query: 42  MLVDRELAWRDTRRLERLLRAAKLKNPQACVEDIEYRQTRGLDQRIVATLAGCDWVRNAQ 101

		           ++     A  + +R    L                 ++   +  R++ T           

		Sbjct: 111 LIGIIGRALAEPKRRPSKLEDDSQDGMPLVGRSAAMQEIYRVLARLMQTDL--------- 161

		

		Query: 102 NLILTGPTGAGKTWLACAFGQQACRQGFSVFYVRVARLFEELK----IAHGDGSFT---- 153

		            L++TG +G GK  +A A      R+      + +A +  +L       H  G+FT    

		Sbjct: 162 TLMITGESGTGKELVARALHDYGKRRNGPFVAINMAAIPRDLIESELFGHEKGAFTGAQT 221

		

		Query: 154 --RRLAQLAKIDVLILDDWGLQDLDQAARNDLLEVLDD----RVGTRSTV 197

		                 + A+   L LD+ G  D+   A+  LL VL       VG R+ +

		Sbjct: 222 RSTGRFEQAEGGTLFLDEIG--DMPMDAQTRLLRVLQQGEYTTVGGRTPI 269

		

		

		>TCRTETB#Tetracycline resistance protein TetB signature.

		          Length = 458

		

		 Score =  119 bits (299), Expect = 3e-31

		 Identities = 84/398 (21%), Positives = 160/398 (40%), Gaps = 16/398 (4%)

		

		Query: 30  LALGTFMEVLDTSIANVAVPTISGSLGVATSEGTWVISSYSVASAIAVPLTGWLARRVGE 89

		           L + +F  VL+  + NV++P I+       +   WV +++ +  +I   + G L+ ++G 

		Sbjct: 19  LCILSFFSVLNEMVLNVSLPDIANDFNKPPASTNWVNTAFMLTFSIGTAVYGKLSDQLGI 78

		

		Query: 90  VRLFTLSVLAFTIASALCGLA-SNFETLIAFRLLQGLVSGPMVPLSQTILMRSYPPAKRG 148

		            RL    ++     S +  +  S F  LI  R +QG  +     L   ++ R  P   RG

		Sbjct: 79  KRLLLFGIIINCFGSVIGFVGHSFFSLLIMARFIQGAGAAAFPALVMVVVARYIPKENRG 138

		

		Query: 149 LALGLWAMTVIVAPIFGPLLGGWISDNYTWPWIFYINLPIGIFSATCAYFLLRGRETRTS 208

		            A GL    V +    GP +GG I+    W ++  I +   I        L   ++    

		Sbjct: 139 KAFGLIGSIVAMGEGVGPAIGGMIAHYIHWSYLLLIPMITIITVPFLMKLL---KKEVRI 195

		

		Query: 209 KQRIDAIGLALLVIGVSCLQMMLDLGKDRDWFNSSFIVALALIAVVSLAFMLVWEATEKE 268

		           K   D  G+ L+ +G+    +          F +S+ ++  +++V+S    +       +

		Sbjct: 196 KGHFDIKGIILMSVGIVFFML----------FTTSYSISFLIVSVLSFLIFVKHIRKVTD 245

		

		Query: 269 PVVDLSLFRDRNFALGALIISFGFMAFFGSVVIFPLWLQTVMGYTAGKAGLATA-PVGLL 327

		           P VD  L ++  F +G L     F    G V + P  ++ V   +  + G     P  + 

		Sbjct: 246 PFVDPGLGKNIPFMIGVLCGGIIFGTVAGFVSMVPYMMKDVHQLSTAEIGSVIIFPGTMS 305

		

		Query: 328 ALVLSPLIGRNMHRLDLRMVASFAFIVFAGVSVWNSTFTLDVPFNHVILPRLVQGIGVAC 387

		            ++   + G  + R     V +   + F  VS   ++F L+     + +  +    G++ 

		Sbjct: 306 VIIFGYIGGILVDRRGPLYVLNIG-VTFLSVSFLTASFLLETTSWFMTIIIVFVLGGLSF 364

		

		Query: 388 FFVPMTTVTLSSISDDRLASASGLSNFLRTLSGAIGTA 425

		               ++T+  SS+      +   L NF   LS   G A

		Sbjct: 365 TKTVISTIVSSSLKQQEAGAGMSLLNFTSFLSEGTGIA 402

		

		

		>PilS_PF08805#PilS N terminal

		          Length = 185

		

		 Score = 28.7 bits (64), Expect = 0.029

		 Identities = 10/40 (25%), Positives = 21/40 (52%)

		

		Query: 1  MRARPSRFRFAARAQRERGAAIITALLVVALSAILVSGML 40

		          MR+  S      + ++++GA ++  LLVV +  +L +   

		Sbjct: 9  MRSVFSSLSARRKKEQDKGATLMEVLLVVGVIVVLAASAY 48

		

		

		>BCTERIALGSPG#Bacterial general secretion pathway protein G

		          signature.

		          Length = 145

		

		 Score = 37.2 bits (86), Expect = 1e-05

		 Identities = 19/63 (30%), Positives = 33/63 (52%), Gaps = 5/63 (7%)

		

		Query: 20 ASRRVRGFTLIELMIAIAILAVVAILAWRGLDQIMRGRDK--VASAMEDERVFAQMFDQM 77

		          A+ + RGFTL+E+M+ I I+ V+A L    +  +M  ++K     A+ D        D  

		Sbjct: 3  ATDKQRGFTLLEIMVVIVIIGVLASLV---VPNLMGNKEKADKQKAVSDIVALENALDMY 59

		

		Query: 78 RID 80

		          ++D

		Sbjct: 60 KLD 62

		

		

		>BCTERIALGSPH#Bacterial general secretion pathway protein H

		          signature.

		          Length = 170

		

		 Score = 27.2 bits (60), Expect = 0.015

		 Identities = 12/58 (20%), Positives = 25/58 (43%), Gaps = 8/58 (13%)

		

		Query: 11 SSQGFTMIEVLVALAIIAVALAASIRAVGTMATNASDLHRRLLAGWSADNALAQLRLA 68

		            +GFT++E+++ L ++ V+    + A      ++        A  +     AQLR  

		Sbjct: 2  RQRGFTLLEMMLILLLMGVSAGMVLLAFPASRDDS--------AAQTLARFEAQLRFV 51

		

		

		>FLGMOTORFLIN#Flagellar motor switch protein FliN signature.

		          Length = 137

		

		 Score = 28.3 bits (63), Expect = 0.010

		 Identities = 24/85 (28%), Positives = 43/85 (50%), Gaps = 5/85 (5%)

		

		Query: 5   ATIARPYAEALFRVAEGGDIAAWSTLVQELAQVAHLPEVLSVASSPKVTRKQVAELLLVA 64

		           AT  +  A+A+F+   GGD+   S  +Q++  +  +P  L+V      TR  + ELL + 

		Sbjct: 28  ATTTKSAADAVFQQLGGGDV---SGAMQDIDLIMDIPVKLTVELGR--TRMTIKELLRLT 82

		

		Query: 65  VKSPLAAGAEAKNFVQMLVDNHRIA 89

		             S +A    A   + +L++ + IA

		Sbjct: 83  QGSVVALDGLAGEPLDILINGYLIA 107

		

		

		>MPTASEINHBTR#Metalloprotease inhibitor signature.

		          Length = 122

		

		 Score = 28.0 bits (62), Expect = 0.018

		 Identities = 12/35 (34%), Positives = 15/35 (42%), Gaps = 2/35 (5%)

		

		Query: 1  MKRFATLAALGAATLFCSGAAHAQAT--AAPAAAS 33

		          M RF+ L       LF S  A A A+    P+ A 

		Sbjct: 1  MPRFSHLIGCVWQVLFVSAGAQAMASSFVVPSTAQ 35

		

		

		>HTHTETR#TetR bacterial regulatory protein HTH signature.

		          Length = 215

		

		 Score = 62.0 bits (150), Expect = 5e-14

		 Identities = 28/142 (19%), Positives = 51/142 (35%), Gaps = 2/142 (1%)

		

		Query: 26  RPRQSRAQATSDALQQAFVQLLLERGHANVTIREIAAVAGVSVGTFYEYFGDKQSLAALC 85

		           R  +  AQ T   +    ++L  ++G ++ ++ EIA  AGV+ G  Y +F DK  L +  

		Sbjct: 3   RKTKQEAQETRQHILDVALRLFSQQGVSSTSLGEIAKAAGVTRGAIYWHFKDKSDLFSEI 62

		

		Query: 86  IHRRVLALAERLRAAAHGLRGMPRAEVAAALVDL--QVEVIAADAALWGALFVLERQVSP 143

		                  + E          G P + +   L+ +            L   +F     V  

		Sbjct: 63  WELSESNIGELELEYQAKFPGDPLSVLREILIHVLESTVTEERRRLLMEIIFHKCEFVGE 122

		

		Query: 144 LAAYRRHYAAYVALWRDALAQA 165

		           +A  ++          D + Q 

		Sbjct: 123 MAVVQQAQRNLCLESYDRIEQT 144

		

		

		>RTXTOXIND#Gram-negative bacterial RTX secretion protein D

		           signature.

		          Length = 478

		

		 Score = 33.3 bits (76), Expect = 5e-04

		 Identities = 17/134 (12%), Positives = 39/134 (29%), Gaps = 2/134 (1%)

		

		Query: 54  RLLRDGLIAVHDTERDGAFPERTLYKLTEAGHKAGQAWL-HALLAEPAREFTAFGAGLAF 112

		           R          +   +   P+   ++            L     +    +       L  

		Sbjct: 152 RYQILSRSIELNKLPELKLPDEPYFQNVSEEEVLRLTSLIKEQFSTWQNQKYQKELNLDK 211

		

		Query: 113 LPLLDADDARRQLERRIDALEAERERLDALRNAAQGDQVPRLFLLQNEHALVMLNAELDW 172

		               +      ++ R  +    E+ RLD   +      + +  +L+ E+  V    EL  

		Sbjct: 212 KRA-ERLTVLARINRYENLSRVEKSRLDDFSSLLHKQAIAKHAVLEQENKYVEAVNELRV 270

		

		Query: 173 TRSVVEHLKIGALR 186

		            +S +E ++   L 

		Sbjct: 271 YKSQLEQIESEILS 284

		

		

		>TCRTETB#Tetracycline resistance protein TetB signature.

		          Length = 458

		

		 Score = 86.1 bits (213), Expect = 5e-20

		 Identities = 85/415 (20%), Positives = 156/415 (37%), Gaps = 22/415 (5%)

		

		Query: 15  RRAWVLAAVCMAAVALPLSFSGGAVATPAIGRDLHGGPVAMNWITNAFMLAFGSCLMAAG 74

		           R   +L  +C+ +    L+     V+ P I  D +  P + NW+  AFML F       G

		Sbjct: 11  RHNQILIWLCILSFFSVLNEMVLNVSLPDIANDFNKPPASTNWVNTAFMLTFSIGTAVYG 70

		

		Query: 75  ALADQFGRKRVFAIGVGGFTLMSVALAFAPSMLAIDLL-RAAQGLAAAAALAGGTAALAQ 133

		            L+DQ G KR+   G+      SV      S  ++ ++ R  QG  AAA  A     +A+

		Sbjct: 71  KLSDQLGIKRLLLFGIIINCFGSVIGFVGHSFFSLLIMARFIQGAGAAAFPALVMVVVAR 130

		

		Query: 134 EFDGAARTRAFSLLGTTFGVGLAFGPVLAGWLIAHHGWRAIFVTGAAAGV-LSLALGLPR 192

		                 R +AF L+G+   +G   GP + G +  +  W  + +      + +   + L +

		Sbjct: 131 YIPKENRGKAFGLIGSIVAMGEGVGPAIGGMIAHYIHWSYLLLIPMITIITVPFLMKLLK 190

		

		Query: 193 MHESRDPHATGLDWPGTVAFTGALTLFTFGVIEAPARGWTDPLVVVLLAGAALGACAFVA 252

		                  H    D  G +  +  +  F            +  +V VL          FV 

		Sbjct: 191 KEVRIKGH---FDIKGIILMSVGIVFFMLFTTSY---SISFLIVSVLSFL------IFVK 238

		

		Query: 253 IETRVARPMLDLSLFR-IPRFVGVQV--LPVSTCCCYIVLLVVLPLRFIGIDGFSEIDAG 309

		              +V  P +D  L + IP  +GV    +   T   ++ +   +P     +   S  + G

		Sbjct: 239 HIRKVTDPFVDPGLGKNIPFMIGVLCGGIIFGTVAGFVSM---VPYMMKDVHQLSTAEIG 295

		

		Query: 310 W-LMLAISAPMLIVPLVAATLTRWLSAGVISGLGLLLAAAGLVWLDVALRGGAGPAAIGP 368

		             ++   +  ++I   +   L        +  +G+   +   +     L   +    I  

		Sbjct: 296 SVIIFPGTMSVIIFGYIGGILVDRRGPLYVLNIGVTFLSVSFLTASFLLETTSWFMTIII 355

		

		Query: 369 MLAIGIGAGMPWGLMDGLSVSVVPKERAGMATGIFSTTRVAGEGIALAIAGAVLA 423

		           +  +G  +     +   +S S+  +E AG    + + T    EG  +AI G +L+

		Sbjct: 356 VFVLGGLSFTKTVISTIVSSSLKQQE-AGAGMSLLNFTSFLSEGTGIAIVGGLLS 409

		

		

		>TCRTETB#Tetracycline resistance protein TetB signature.

		          Length = 458

		

		 Score = 42.2 bits (99), Expect = 3e-06

		 Identities = 40/173 (23%), Positives = 74/173 (42%), Gaps = 14/173 (8%)

		

		Query: 22  WLVLAVLFAVTTINYADRAAIAIAGPAIARAMHLSHVQMGFIFSAFGWSYVIAQLPGGWL 81

		           WL +   F+V      +   + ++ P IA   +       ++ +AF  ++ I     G L

		Sbjct: 18  WLCILSFFSVL-----NEMVLNVSLPDIANDFNKPPASTNWVNTAFMLTFSIGTAVYGKL 72

		

		Query: 82  LDRFGSRIVYAFSIFFWSLFTLLQGGIGFIGGAAAFGLLFALRFLVGAAEAPSFPANSRI 141

		            D+ G + +  F I      ++    IGF+G +    L+ A RF+ GA  A +FPA   +

		Sbjct: 73  SDQLGIKRLLLFGIIINCFGSV----IGFVGHSFFSLLIMA-RFIQGAGAA-AFPALVMV 126

		

		Query: 142 -VSTWFPAAERGTASAIFNAAQYAATVVFAPLMGWLV-HAFGWQWVFAVMGVL 192

		            V+ + P   RG A  +   +  A      P +G ++ H   W ++  +  + 

		Sbjct: 127 VVARYIPKENRGKAFGLI-GSIVAMGEGVGPAIGGMIAHYIHWSYLLLIPMIT 178

		

		

		>PF05272#Virulence-associated E family protein

		          Length = 892

		

		 Score = 28.1 bits (62), Expect = 0.035

		 Identities = 15/52 (28%), Positives = 22/52 (42%), Gaps = 13/52 (25%)

		

		Query: 14  IRHVAKSYRRGNQVVPVLTDITLDIAAGDFVALMGPSGSGKSTLLNLVAGID 65

		           + HVA+    G +    +              L G  G GKSTL+N + G+D

		Sbjct: 582 MGHVARVMEPGCKFDYSVV-------------LEGTGGIGKSTLINTLVGLD 620

		

		

		>RTXTOXIND#Gram-negative bacterial RTX secretion protein D

		           signature.

		          Length = 478

		

		 Score = 54.8 bits (132), Expect = 2e-10

		 Identities = 29/189 (15%), Positives = 62/189 (32%), Gaps = 22/189 (11%)

		

		Query: 9   LKIDRRPLAPAPRRRRWVRYAAAAALVAAAIAAALVLTSRPTVDTTSVTTAYPYQNDTQL 68

		           L++   P++  PR   +         +   +  A +L+    V+  +             

		Sbjct: 46  LELIETPVSRRPRLVAY--------FIMGFLVIAFILSVLGQVEIVAT------------ 85

		

		Query: 69  NATGYVVPQ-RKAAVASKGQGRVEWLGVLEGTRVKKGDIIARLESRDVEASLAQARAQVL 127

		            A G +    R   +       V+ + V EG  V+KGD++ +L +   EA   + ++ +L

		Sbjct: 86  -ANGKLTHSGRSKEIKPIENSIVKEIIVKEGESVRKGDVLLKLTALGAEADTLKTQSSLL 144

		

		Query: 128 VSRANLGVAQAELKDAEIALRRTAVLAPKGAVPAAQLDIDTARVNKARATLGSDQAAIAS 187

		            +R      Q   +  E+       L  +        +      +  +    + Q     

		Sbjct: 145 QARLEQTRYQILSRSIELNKLPELKLPDEPYFQNVSEEEVLRLTSLIKEQFSTWQNQKYQ 204

		

		Query: 188 AEANAQAAQ 196

		            E N    +

		Sbjct: 205 KELNLDKKR 213

		

		

		

		 Score = 48.7 bits (116), Expect = 2e-08

		 Identities = 41/193 (21%), Positives = 66/193 (34%), Gaps = 44/193 (22%)

		

		Query: 107 IARLESRDVEASLAQARAQVLVSRANLGVAQAELKDAEIALRRTAVLAPKGAVPAAQLDI 166

		           IA+    + E    +A  ++ V ++ L   ++E+  A+   +                 +

		Sbjct: 249 IAKHAVLEQENKYVEAVNELRVYKSQLEQIESEILSAKEEYQL----------------V 292

		

		Query: 167 DTARVNKARATLGSDQAAIASAEANAQAAQVAVDQTVIRAPFDGIV--LAKHANVGDNIT 224

		                N+    L      I          +     +VIRAP    V  L  H        

		Sbjct: 293 TQLFKNEILDKLRQTTDNIGLLTLELAKNEERQQASVIRAPVSVKVQQLKVH-------- 344

		

		Query: 225 PFSSASDSKGAVVTIA--------DMDTLEVEADVAESNIAKIRSEQPCEIQLDALPDMR 276

		                  ++G VVT A        + DTLEV A V   +I  I   Q   I+++A P  R

		Sbjct: 345 -------TEGGVVTTAETLMVIVPEDDTLEVTALVQNKDIGFINVGQNAIIKVEAFPYTR 397

		

		Query: 277 F---AGRVSRIVP 286

		           +    G+V  I  

		Sbjct: 398 YGYLVGKVKNINL 410

		

		

		>TCRTETOQM#Tetracycline resistance protein TetO/TetQ/TetM family

		           signature.

		          Length = 639

		

		 Score = 85.7 bits (212), Expect = 3e-20

		 Identities = 52/149 (34%), Positives = 77/149 (51%), Gaps = 5/149 (3%)

		

		Query: 13  VNVGTIGHVDHGKTTLTAAI--TTVLTKKFGGEAKAYDQIDAAPEEKARGITINTAHVEY 70

		           +N+G + HVD GKTTLT ++   +    + G   K   + D    E+ RGITI T    +

		Sbjct: 4   INIGVLAHVDAGKTTLTESLLYNSGAITELGSVDKGTTRTDNTLLERQRGITIQTGITSF 63

		

		Query: 71  ETANRHYAHVDCPGHADYVKNMITGAAQMDGAILVCSAADGPMPQTREHILLARQVGVPY 130

		           +  N     +D PGH D++  +    + +DGAIL+ SA DG   QTR      R++G+P 

		Sbjct: 64  QWENTKVNIIDTPGHMDFLAEVYRSLSVLDGAILLISAKDGVQAQTRILFHALRKMGIP- 122

		

		Query: 131 IIVFLNKCDMVDDAELLELVEMEVRELLS 159

		            I F+NK D       L  V  +++E LS

		Sbjct: 123 TIFFINKIDQN--GIDLSTVYQDIKEKLS 149

		

		

		>SECETRNLCASE#Bacterial translocase SecE signature.

		          Length = 127

		

		 Score = 72.2 bits (177), Expect = 1e-19

		 Identities = 37/113 (32%), Positives = 60/113 (53%)

		

		Query: 2   ANPSVETVNTSGDKLMLALGVLLVLAGFVGFFWLANQQWYVRGAALAVGIIAGVAVGLMS 61

		           AN   +      + +   + V L+L   VG +   +    +R  A+ + I A   V L++

		Sbjct: 3   ANTEAQGSGRGLEAMKWVVVVALLLVAIVGNYLYRDIMLPLRALAVVILIAAAGGVALLT 62

		

		Query: 62  APGKSLIAFAKDSYKEVRKVVWPTRKEATQTTLVVFGFVLVMAIFLWLSDKSI 114

		             GK+ +AFA+++  EVRKV+WPTR+E   TTL+V     VM++ LW  D  +

		Sbjct: 63  TKGKATVAFAREARTEVRKVIWPTRQETLHTTLIVAAVTAVMSLILWGLDGIL 115

		

		

		>TCRTETOQM#Tetracycline resistance protein TetO/TetQ/TetM family

		           signature.

		          Length = 639

		

		 Score =  620 bits (1601), Expect = 0.0

		 Identities = 168/681 (24%), Positives = 299/681 (43%), Gaps = 72/681 (10%)

		

		Query: 9   RYRNIGISAHIDAGKTTTTERILFYTGVNHKIGEVHDGAATMDWMEQEQERGITITSAAT 68

		           +  NIG+ AH+DAGKTT TE +L+ +G   ++G V  G    D    E++RGITI +  T

		Sbjct: 2   KIINIGVLAHVDAGKTTLTESLLYNSGAITELGSVDKGTTRTDNTLLERQRGITIQTGIT 61

		

		Query: 69  TAFWKGMGGNYPEHRINIIDTPGHVDFTIEVERSMRVLDGACMVYCAVGGVQPQSETVWR 128

		           +  W+         ++NIIDTPGH+DF  EV RS+ VLDGA ++  A  GVQ Q+  ++ 

		Sbjct: 62  SFQWEN-------TKVNIIDTPGHMDFLAEVYRSLSVLDGAILLISAKDGVQAQTRILFH 114

		

		Query: 129 QANKYKVPRLAFVNKMDRTGANFFKVYDQLRLRLKANPVPVVVPIGSEENFKGVVDLIKM 188

		              K  +P + F+NK+D+ G +   VY  ++ +L A  V                  IK 

		Sbjct: 115 ALRKMGIPTIFFINKIDQNGIDLSTVYQDIKEKLSAEIV------------------IKQ 156

		

		Query: 189 KAIIWDEASQGTKFDYVDIPAELAETCKEWREKMVEAAAEASEDLMNKYLEEGDLPEADI 248

		           K              Y ++        ++W     +   E ++DL+ KY+    L   ++

		Sbjct: 157 KV-----------ELYPNMCVTNFTESEQW-----DTVIEGNDDLLEKYMSGKSLEALEL 200

		

		Query: 249 IKALRDRTIACEIQPMLCGTAFKNKGVQRMLDAVIDFLPSPVDIPPVKGELENGEAAERK 308

		            +    R   C + P+  G+A  N G+  +++ + +   S                    

		Sbjct: 201 EQEESIRFHNCSLFPVYHGSAKNNIGIDNLIEVITNKFYSSTH----------------- 243

		

		Query: 309 ASDEEKFSSLAFKIMTDPFVGQLIFFRVYSGVVNSGDTLLNSTKGKKERLGRILQMHANQ 368

		              + +     FKI       +L + R+YSGV++  D++  S K K  ++  +      +

		Sbjct: 244 -RGQSELCGKVFKIEYSEKRQRLAYIRLYSGVLHLRDSVRISEKEKI-KITEMYTSINGE 301

		

		Query: 369 REEIKEVRAGDIAAAVG--LK-EATTGDTLCDPANPIVLERMVFPEPVISQAVEPKTKAD 425

		             +I +  +G+I       LK  +  GDT   P      ER+  P P++   VEP     

		Sbjct: 302 LCKIDKAYSGEIVILQNEFLKLNSVLGDTKLLPQR----ERIENPLPLLQTTVEPSKPQQ 357

		

		Query: 426 QEKMGLALNRLAQEDPSFRVQTDEESGQTIISGMGELHLEILVDRMKREFGVEATVGKPQ 485

		           +E +  AL  ++  DP  R   D  + + I+S +G++ +E+    ++ ++ VE  + +P 

		Sbjct: 358 REMLLDALLEISDSDPLLRYYVDSATHEIILSFLGKVQMEVTCALLQEKYHVEIEIKEPT 417

		

		Query: 486 VAYRETIRSTAKDVDGKFVKQSGGRGQYGHAVITLEPNEQGKGYEFFDEIKGGVIPREYI 545

		           V Y E      K  +     +      +    +++ P   G G ++   +  G + + + 

		Sbjct: 418 VIYMERP---LKKAEYTIHIEVPPNPFWASIGLSVSPLPLGSGMQYESSVSLGYLNQSFQ 474

		

		Query: 546 PAVDKGIQDTLKSGVLAGFPVVDVKVHLTFGSYHDVDSNENAFRMAGSMAFKEAMRKANP 605

		            AV +GI+   + G L G+ V D K+   +G Y+   S    FRM   +  ++ ++KA  

		Sbjct: 475 NAVMEGIRYGCEQG-LYGWNVTDCKICFKYGLYYSPVSTPADFRMLAPIVLEQVLKKAGT 533

		

		Query: 606 VVLEPMMAVEVETPEDYMGNVMGDLSGRRGIVQGMEDMVGGGKIVRAEVPLSEMFGYSTS 665

		            +LEP ++ ++  P++Y+     D       +   + +     I+  E+P   +  Y + 

		Sbjct: 534 ELLEPYLSFKIYAPQEYLSRAYTDAPKYCANIVDTQ-LKNNEVILSGEIPARCIQEYRSD 592

		

		Query: 666 LRSLTQGRATYTMEFKHYAEA 686

		           L   T GR+    E K Y   

		Sbjct: 593 LTFFTNGRSVCLTELKGYHVT 613

		

		

		>TCRTETOQM#Tetracycline resistance protein TetO/TetQ/TetM family

		           signature.

		          Length = 639

		

		 Score = 85.7 bits (212), Expect = 3e-20

		 Identities = 52/149 (34%), Positives = 77/149 (51%), Gaps = 5/149 (3%)

		

		Query: 13  VNVGTIGHVDHGKTTLTAAI--TTVLTKKFGGEAKAYDQIDAAPEEKARGITINTAHVEY 70

		           +N+G + HVD GKTTLT ++   +    + G   K   + D    E+ RGITI T    +

		Sbjct: 4   INIGVLAHVDAGKTTLTESLLYNSGAITELGSVDKGTTRTDNTLLERQRGITIQTGITSF 63

		

		Query: 71  ETANRHYAHVDCPGHADYVKNMITGAAQMDGAILVCSAADGPMPQTREHILLARQVGVPY 130

		           +  N     +D PGH D++  +    + +DGAIL+ SA DG   QTR      R++G+P 

		Sbjct: 64  QWENTKVNIIDTPGHMDFLAEVYRSLSVLDGAILLISAKDGVQAQTRILFHALRKMGIP- 122

		

		Query: 131 IIVFLNKCDMVDDAELLELVEMEVRELLS 159

		            I F+NK D       L  V  +++E LS

		Sbjct: 123 TIFFINKIDQN--GIDLSTVYQDIKEKLS 149

		

		

		>SECYTRNLCASE#Preprotein translocase SecY subunit signature.

		          Length = 437

		

		 Score =  447 bits (1152), Expect = e-158

		 Identities = 193/432 (44%), Positives = 273/432 (63%), Gaps = 20/432 (4%)

		

		Query: 19  DLRRRAMFLLLALIVYRIGAHIPVPGIDPDQLAKLFQSQAG--GILGMFNMFSGGALSRF 76

		           DLR++ +F L  ++VYR+G HIP+PG+D   + +  +  +G  G+ G+ NMFSGGAL + 

		Sbjct: 13  DLRKKLLFTLAIIVVYRVGTHIPIPGVDYKNVQQCVREASGNQGLFGLVNMFSGGALLQI 72

		

		Query: 77  TIFALGIMPYISASIIMQLLAIVSPQLEALKKEGQAGQRKITQYTRYFTVVLATFQAFGI 136

		           TIFALGIMPYI+ASII+QLL +V P+LEALKKEGQAG  KITQYTRY TV LA  Q  G+

		Sbjct: 73  TIFALGIMPYITASIILQLLTVVIPRLEALKKEGQAGTAKITQYTRYLTVALAILQGTGL 132

		

		Query: 137 AAALENQP---------GLVIDPGMLFRLTTVVTLVTGTMFLMWLGEQITERGLGNGISI 187

		            A   + P          +V D  +   +T V+ +  GT  +MWLGE IT+RG+GNG+SI

		Sbjct: 133 VATARSAPLFGRCSVGGQIVPDQSIFTTITMVICMTAGTCVVMWLGELITDRGIGNGMSI 192

		

		Query: 188 IIFGGIAAGFPNAVGGLFELVRTGSMSIISAIIIVVLIAAVTYLVVFIERGQRKILVNYA 247

		           ++F  IAA FP+A+  + +        I    +I V +  +  LVVF+E+ QR+I V YA

		Sbjct: 193 LMFISIAATFPSALWAIKKQGTLAGGWIEFGTVIAVGL-IMVALVVFVEQAQRRIPVQYA 251

		

		Query: 248 KRQVGNKIYGGQSSHLPLKLNMSGVIPPIFASSIILFPATILGWFSTGQPSGSWISNTLH 307

		           KR +G + YGG S+++PLK+N +GVIP IFASS++  PA +  +        SW+   L 

		Sbjct: 252 KRMIGRRSYGGTSTYIPLKVNQAGVIPVIFASSLLYIPALVAQFAGGNSGWKSWVEQNL- 310

		

		Query: 308 NVAEALKPGQPVYVLLYTLAIVFFCFFYTALVFNSRETADNLKKSGAFVPGIRPGDQTAR 367

		                 K   P+Y++ Y L IVFF FFY A+ FN  E ADN+KK G F+PGIR G  TA 

		Sbjct: 311 -----TKGDHPIYIVTYFLLIVFFAFFYVAISFNPEEVADNMKKYGGFIPGIRAGRPTAE 365

		

		Query: 368 YIDRILTRLTLAGAIYIVFVCLLPEFLVLRWNVP--FYFGGTSLLIIVVVTMDFMAQVQS 425

		           Y+  +L R+T  G++Y+  + L+P   ++ +     F FGGTS+LIIV V ++ + Q++S

		Sbjct: 366 YLSYVLNRITWPGSLYLGLIALVPTMALVGFGASQNFPFGGTSILIIVGVGLETVKQIES 425

		

		Query: 426 YVMSQQYESLLK 437

		            +  + YE  L+

		Sbjct: 426 QLQQRNYEGFLR 437

		

		

		>V8PROTEASE#V8 serine protease family signature.

		          Length = 336

		

		 Score = 67.0 bits (163), Expect = 2e-14

		 Identities = 33/183 (18%), Positives = 63/183 (34%), Gaps = 38/183 (20%)

		

		Query: 117 NLGSGVIVSPEGYILTNQHVVDGADQIEVALA------------DGRTATAKVIGSDPET 164

		            + SGV+V     +LTN+HVVD       AL             +G     ++     E 

		Sbjct: 102 FIASGVVVGK-DTLLTNKHVVDATHGDPHALKAFPSAINQDNYPNGGFTAEQITKYSGEG 160

		

		Query: 165 DLAVLKINMTD--------LPTITLGRSDRSRVGDVVLAIGNPFGVGQTVTMGIISALGR 216

		           DLA++K +  +        +   T+  +  ++V   +   G P           ++ +  

		Sbjct: 161 DLAIVKFSPNEQNKHIGEVVKPATMSNNAETQVNQNITVTGYPGD-------KPVATMWE 213

		

		Query: 217 NHLGINTFEN-FIQTDAPINPGNSGGALVDVNGNLLGINTAIYSRSGGSLGIGFAIPVST 275

		           +   I   +   +Q D     GNSG  + +    ++GI+           G+      + 

		Sbjct: 214 SKGKITYLKGEAMQYDLSTTGGNSGSPVFNEKNEVIGIHWG---------GVPNEFNGAV 264

		

		Query: 276 ART 278

		              

		Sbjct: 265 FIN 267

		

		

		>RTXTOXINA#Gram-negative bacterial RTX toxin determinant A family

		            signature.

		          Length = 1024

		

		 Score = 32.2 bits (73), Expect = 0.013

		 Identities = 27/135 (20%), Positives = 54/135 (40%), Gaps = 12/135 (8%)

		

		Query: 913  SPEAAQAAASGQLASQLQGMAPAASTA---AMGFASGSGAGAALGGLAGAALPAAAAAVG 969

		            +    +AAA  +L +++ G      +    A   A G    AA  GL  +A+  A + + 

		Sbjct: 263  ADTRTKAAAGVELTTKVLGNVGKGISQYIIAQRAAQGLSTSAAAAGLIASAVTLAISPLS 322

		

		Query: 970  GAGVASAVQTASSLSGAAKQVAAMVQTARQGGLAALA-----APAANAASGALQSALPGV 1024

		               +A   + A+ +   +++   +       G + LA       A +A+   + + L  V

		Sbjct: 323  FLSIADKFKRANKIEEYSQRFKKL----GYDGDSLLAAFHKETGAIDASLTTISTVLASV 378

		

		Query: 1025 AGVAGKAATTTATAS 1039

		            +     AATT+   +

		Sbjct: 379  SSGISAAATTSLVGA 393

		

		

		>SSPANPROTEIN#Salmonella invasion protein InvJ signature.

		          Length = 336

		

		 Score = 28.2 bits (62), Expect = 0.023

		 Identities = 22/58 (37%), Positives = 27/58 (46%), Gaps = 5/58 (8%)

		

		Query: 23  AAPLLGSAASAVMQAAGIGKPELPDSQKPPRNIGL-----TLAAASNLNAANDRKPLA 75

		            APL    A A M AA  GKPE  D +K      L     T+A  S L   +++ PLA

		Sbjct: 183 GAPLARDVAPARMAAANTGKPEDKDHKKVKDVSQLPLQPTTIADLSQLTGGDEKMPLA 240

		

		

		>DHBDHDRGNASE#2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase

		           signature.

		          Length = 261

		

		 Score =  131 bits (331), Expect = 2e-39

		 Identities = 81/254 (31%), Positives = 134/254 (52%), Gaps = 8/254 (3%)

		

		Query: 4   LAGKVAAVTGAARGIGAAIAHAFAREGACVALLDVDVEHAQRTAAAIAAEVDGARVLALH 63

		           + GK+A +TGAA+GIG A+A   A +GA +A +D + E  ++  +++ AE   A   A  

		Sbjct: 6   IEGKIAFITGAAQGIGEAVARTLASQGAHIAAVDYNPEKLEKVVSSLKAEARHAE--AFP 63

		

		Query: 64  ADVTRQDSVRAALARTEAEFGPLDVLVNNAGINVFADPLTMSDDDWRRCFAVDLDGVWHG 123

		           ADV    ++    AR E E GP+D+LVN AG+       ++SD++W   F+V+  GV++ 

		Sbjct: 64  ADVRDSAAIDEITARIEREMGPIDILVNVAGVLRPGLIHSLSDEEWEATFSVNSTGVFNA 123

		

		Query: 124 CRAALPGMVERGRGCIVNIASTHAFSIIPGCFPYPVAKHGVLGLTRALGIEYAAHNVRVN 183

		            R+    M++R  G IV + S  A         Y  +K   +  T+ LG+E A +N+R N

		Sbjct: 124 SRSVSKYMMDRRSGSIVTVGSNPAGVPRTSMAAYASSKAAAVMFTKCLGLELAEYNIRCN 183

		

		Query: 184 AIAPGYIDTQLTRDWWEAQDDPAAARAQTLALQ-----PMKRIGQPDEVAMTAVFLASDE 238

		            ++PG  +T +    W A ++ A    +          P+K++ +P ++A   +FL S +

		Sbjct: 184 IVSPGSTETDMQWSLW-ADENGAEQVIKGSLETFKTGIPLKKLAKPSDIADAVLFLVSGQ 242

		

		Query: 239 APFINATCITVDGG 252

		           A  I    + VDGG

		Sbjct: 243 AGHITMHNLCVDGG 256

		

		

		>PF05272#Virulence-associated E family protein

		          Length = 892

		

		 Score = 29.3 bits (65), Expect = 0.041

		 Identities = 14/38 (36%), Positives = 17/38 (44%), Gaps = 5/38 (13%)

		

		Query: 18  RALD-GISFDVHAGEVHGLMGENGAGKSTLLKILGGEY 54

		           R ++ G  FD        L G  G GKSTL+  L G  

		Sbjct: 587 RVMEPGCKFDY----SVVLEGTGGIGKSTLINTLVGLD 620

		

		

		>DHBDHDRGNASE#2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase

		           signature.

		          Length = 261

		

		 Score =  115 bits (289), Expect = 4e-33

		 Identities = 76/251 (30%), Positives = 113/251 (45%), Gaps = 11/251 (4%)

		

		Query: 21  RAVLITGGATGIGASFVEHFARQGARVAFVDLDAQAGAALAERLVGEPEVRHAPLFVACD 80

		           +   ITG A GIG +     A QGA +A VD + +    +   L  + E RHA  F A D

		Sbjct: 9   KIAFITGAAQGIGEAVARTLASQGAHIAAVDYNPEKLEKVVSSL--KAEARHAEAFPA-D 65

		

		Query: 81  LTDIDALRGTIDAIRARLGAIDVLVNNAANDARHAIADVTPASFDAGIAVNLRHQFFAAQ 140

		           + D  A+      I   +G ID+LVN A       I  ++   ++A  +VN    F A++

		Sbjct: 66  VRDSAAIDEITARIEREMGPIDILVNVAGVLRPGLIHSLSDEEWEATFSVNSTGVFNASR 125

		

		Query: 141 AVIDDMKRQGGGAIINLGSISWMLKNGGYPVYVMAKAAVQGLTRGLARDLGPFGIRVNSL 200

		           +V   M  +  G+I+ +GS    +       Y  +KAA    T+ L  +L  + IR N +

		Sbjct: 126 SVSKYMMDRRSGSIVTVGSNPAGVPRTSMAAYASSKAAAVMFTKCLGLELAEYNIRCNIV 185

		

		Query: 201 VPGWVMTDKQRRLWLDDAGRAAIKAGQCIDAEL--------LPDDLARMALFLAADDSRM 252

		            PG   TD Q  LW D+ G   +  G     +          P D+A   LFL +  +  

		Sbjct: 186 SPGSTETDMQWSLWADENGAEQVIKGSLETFKTGIPLKKLAKPSDIADAVLFLVSGQAGH 245

		

		Query: 253 ITAQDVVVDGG 263

		           IT  ++ VDGG

		Sbjct: 246 ITMHNLCVDGG 256

		

		

		>TCRTETA#Tetracycline resistance protein signature.

		          Length = 399

		

		 Score = 52.9 bits (127), Expect = 1e-09

		 Identities = 82/399 (20%), Positives = 132/399 (33%), Gaps = 61/399 (15%)

		

		Query: 50  VAPSVIAEWHVPKQA---LGPVFSASLFGMLLGALGLSVLADRIGRRPVLIGSTLFFAVT 106

		           V P ++ +           G + +         A  L  L+DR GRRPVL+ S    AV 

		Sbjct: 27  VLPGLLRDLVHSNDVTAHYGILLALYALMQFACAPVLGALSDRFGRRPVLLVSLAGAAVD 86

		

		Query: 107 MLATPFASSIPVLIALRFVTGLGLGCIMPNAMALVGEFSPAAHGVKRM----MIVSCGFT 162

		                 A  + VL   R V G+  G     A A + + +      +           G  

		Sbjct: 87  YAIMATAPFLWVLYIGRIVAGIT-GATGAVAGAYIADITDGDERARHFGFMSACFGFGMV 145

		

		Query: 163 LGAALGGFISAALIPALGWRAVFFVGGAVPLVLAIAMLARLPESLQFLVLKGRVAQARDW 222

		            G  LGG +           A FF   A+  +  +     LPES +              

		Sbjct: 146 AGPVLGGLMG-----GFSPHAPFFAAAALNGLNFLTGCFLLPESHK-------------- 186

		

		Query: 223 LARFAPHAGIDADTRLVVRERAASGAPVAELFRAGRLPVTLLLWAISF-MNLIDLYFLSN 281

		                         R  +R  A +  P+A    A  + V   L A+ F M L+     + 

		Sbjct: 187 ------------GERRPLRREALN--PLASFRWARGMTVVAALMAVFFIMQLVGQVPAAL 232

		

		Query: 282 WLPTVMRDAGYTPGTAVIVGTVLQTGGVIGTLS----LGWFIERYGFVRVLFACFACAAV 337

		           W+        +   T   +G  L   G++ +L+     G    R G  R L         

		Sbjct: 233 WVIFGEDRFHWDATT---IGISLAAFGILHSLAQAMITGPVAARLGERRALMLGMIADGT 289

		

		Query: 338 SVGLIGSVAHA-LPWLLVVVFAGGFCVVGGQPAVNALAGQYYPTSLRSTGIGWSLGIGRI 396

		              L+       + + ++V+ A G     G PA+ A+  +      +    G    +  +

		Sbjct: 290 GYILLAFATRGWMAFPIMVLLASGGI---GMPALQAMLSRQVDEERQGQLQGSLAALTSL 346

		

		Query: 397 GSVLGPLVGGQLIALN--------WSNGALFHAAALPVL 427

		            S++GPL+   + A +        W  GA  +   LP L

		Sbjct: 347 TSIVGPLLFTAIYAASITTWNGWAWIAGAALYLLCLPAL 385

		

		

		>TCRTETA#Tetracycline resistance protein signature.

		          Length = 399

		

		 Score = 47.5 bits (113), Expect = 5e-08

		 Identities = 87/362 (24%), Positives = 143/362 (39%), Gaps = 24/362 (6%)

		

		Query: 6   SRDFVALILSVAVVGLGTGATLPLTALALTEAGHGTNVV---GMLTAAQALGGLAIVPFV 62

		           +R  + ++ +VA+  +G G  +P+    L +  H  +V    G+L A  AL   A  P +

		Sbjct: 4   NRPLIVILSTVALDAVGIGLIMPVLPGLLRDLVHSNDVTAHYGILLALYALMQFACAPVL 63

		

		Query: 63  TALARRLGARRAIVVSVVLLAAATALMQFTSNLIVWGVLRVLCGAALMLLFTIGEAWVNQ 122

		            AL+ R G R  ++VS+   A   A+M     L V  + R++ G         G A++  

		Sbjct: 64  GALSDRFGRRPVLLVSLAGAAVDYAIMATAPFLWVLYIGRIVAGITGATGAVAG-AYIAD 122

		

		Query: 123 LADDSTRGRVVAIYATNFTLFQMAGPVLVSQIAGATS-IRFALCGALFLLA-------LP 174

		           + D   R R     +  F    +AGPVL   + G +    F    AL  L        LP

		Sbjct: 123 ITDGDERARHFGFMSACFGFGMVAGPVLGGLMGGFSPHAPFFAAAALNGLNFLTGCFLLP 182

		

		Query: 175 TLATIRRAPLAGDDARQAAHDSWLAVLPRMPALIIGTGFFALFDTLALSLLPLYAMD--H 232

		                 R PL  +     A   W   +  + AL+       L   +  +L  ++  D  H

		Sbjct: 183 ESHKGERRPLRREALNPLASFRWARGMTVVAALMAVFFIMQLVGQVPAALWVIFGEDRFH 242

		

		Query: 233 GVASATAVLLASIMLCGDTAMQFPIGWLADKLGRERVHLGAGCIVLAGLPLLPFVIADPW 292

		             A+   + LA+  +    A     G +A +LG  R  +        G  LL F     W

		Sbjct: 243 WDATTIGISLAAFGILHSLAQAMITGPVAARLGERRALMLGMIADGTGYILLAF-ATRGW 301

		

		Query: 293 LCWPLLFVLGAADGSIYTL----SLVACGERFRGAALVTASSLVSASWSAASFGGPLVAG 348

		           + +P++ +L +    +  L    S     ER +G    + ++L     S  S  GPL+  

		Sbjct: 302 MAFPIMVLLASGGIGMPALQAMLSRQVDEER-QGQLQGSLAALT----SLTSIVGPLLFT 356

		

		Query: 349 AL 350

		           A+

		Sbjct: 357 AI 358

		

		

		>TCRTETB#Tetracycline resistance protein TetB signature.

		          Length = 458

		

		 Score = 46.0 bits (109), Expect = 2e-07

		 Identities = 30/153 (19%), Positives = 66/153 (43%), Gaps = 1/153 (0%)

		

		Query: 5   LFALAVAAFGIGTTEFVIMGLLPNVARDLGVSIPAAGMLVSGYALGVTIGAPILAVVTAK 64

		           L  L + +F     E V+   LP++A D      +   + + + L  +IG  +   ++ +

		Sbjct: 16  LIWLCILSFFSVLNEMVLNVSLPDIANDFNKPPASTNWVNTAFMLTFSIGTAVYGKLSDQ 75

		

		Query: 65  MPRKRALMGLIGLFIAGNLLCALAPGYA-VLMAARVVTAFCHGAFFGIGSVVASSLVAPN 123

		           +  KR L+  I +   G+++  +   +  +L+ AR +      AF  +  VV +  +   

		Sbjct: 76  LGIKRLLLFGIIINCFGSVIGFVGHSFFSLLIMARFIQGAGAAAFPALVMVVVARYIPKE 135

		

		Query: 124 RRAQAIALMFTGLTLANVLGVPLGTALGQAYGW 156

		            R +A  L+ + + +   +G  +G  +     W

		Sbjct: 136 NRGKAFGLIGSIVAMGEGVGPAIGGMIAHYIHW 168

		

		

		>TCRTETA#Tetracycline resistance protein signature.

		          Length = 399

		

		 Score = 30.6 bits (69), Expect = 0.011

		 Identities = 76/363 (20%), Positives = 128/363 (35%), Gaps = 36/363 (9%)

		

		Query: 18  QIVSVVCFTFVCYLTIGLPLAVLPGFVHDDLGYSAIVAGAAISVQYFAT--LASRPLAGR 75

		            ++ ++    +  + IGL + VLPG + D +  + + A   I +  +A    A  P+ G 

		Sbjct: 6   PLIVILSTVALDAVGIGLIMPVLPGLLRDLVHSNDVTAHYGILLALYALMQFACAPVLGA 65

		

		Query: 76  FADTLGPKQTVLRGLIGCGVSGVLLLVALLLARWPAASLVLLIGSRLVLGV-GESLCGTG 134

		            +D  G +  +L  L G  V   ++  A  L        VL IG R+V G+ G +    G

		Sbjct: 66  LSDRFGRRPVLLVSLAGAAVDYAIMATAPFLW-------VLYIG-RIVAGITGATGAVAG 117

		

		Query: 135 AILWGIGRVGIAHNAKVISWNGIATYGALALGAPVGVAIAHALNPALIGVLVIALAAAGF 194

		           A +  I        A+   +   A +G   +  PV   +    +P        AL    F

		Sbjct: 118 AYIADI--TDGDERARHFGFMS-ACFGFGMVAGPVLGGLMGGFSPHAPFFAAAALNGLNF 174

		

		Query: 195 YLARLIDAVPLVHGERMSYAS-------------VFTRVLPHGLGLALGSAGFGSI-ATF 240

		                +  +P  H                         V+   + +       G + A  

		Sbjct: 175 LTGCFL--LPESHKGERRPLRREALNPLASFRWARGMTVVAALMAVFFIMQLVGQVPAAL 232

		

		Query: 241 VTLYYAAR-HWPNA--ALSLTVFGTLFIGARLLFANMIKTYGGFRVAI-VSFAFESSGLL 296

		             ++   R HW      +SL  FG L   A+ +    +    G R A+ +    + +G +

		Sbjct: 233 WVIFGEDRFHWDATTIGISLAAFGILHSLAQAMITGPVAARLGERRALMLGMIADGTGYI 292

		

		Query: 297 LLWLAPVPHVALVGAALTGFGFALIFPALGVEAVALVPPASRGAALSAYSVFLDLSLGIT 356

		           LL  A    +A     L   G  +  PAL       V    +G    + +    L+  I 

		Sbjct: 293 LLAFATRGWMAFPIMVLLASG-GIGMPALQAMLSRQVDEERQGQLQGSLAALTSLT-SIV 350

		

		Query: 357 GPL 359

		           GPL

		Sbjct: 351 GPL 353

		

		

		>TCRTETB#Tetracycline resistance protein TetB signature.

		          Length = 458

		

		 Score =  124 bits (314), Expect = 2e-33

		 Identities = 78/413 (18%), Positives = 169/413 (40%), Gaps = 28/413 (6%)

		

		Query: 14  LIVLCLGVLMIVLDSTIVNVALPSIGADLHFTGTALVWVVNAYLLTFGGCLLLGGRLGDL 73

		           LI LC+     VL+  ++NV+LP I  D +    +  WV  A++LTF     + G+L D 

		Sbjct: 16  LIWLCILSFFSVLNEMVLNVSLPDIANDFNKPPASTNWVNTAFMLTFSIGTAVYGKLSDQ 75

		

		Query: 74  YGQRRMFLAGLVVFTLASLACGVAPSQ-TLLIAARAVQGFGGAVVSAVSLSLIMNLFTEP 132

		            G +R+ L G+++    S+   V  S  +LLI AR +QG G A   A+ + +++  +   

		Sbjct: 76  LGIKRLLLFGIIINCFGSVIGFVGHSFFSLLIMARFIQGAGAAAFPALVM-VVVARYIPK 134

		

		Query: 133 GERARAMGVYGFVCAGGGSLGVLLGGLLTSTLSWHWIFLVNLPIGIAVYAMCVALLPRVR 192

		             R +A G+ G + A G  +G  +GG++   +  HW +L+ +P+        + +   ++

		Sbjct: 135 ENRGKAFGLIGSIVAMGEGVGPAIGGMIAHYI--HWSYLLLIPM-----ITIITVPFLMK 187

		

		Query: 193 VPADAAR----LDVAGALTVTASLMLAVYGIVGGNEAGWLSPQTVGLIGAALALLAAFIA 248

		           +     R     D+ G + ++  ++  +          +L    +  +         F+ 

		Sbjct: 188 LLKKEVRIKGHFDIKGIILMSVGIVFFMLF-TTSYSISFLIVSVLSFL--------IFVK 238

		

		Query: 249 IEARVAHPLMPLTLFAARNVALANVIGVLWAAAMFAWFFLSALYMQRVLGYGPLQVGLAF 308

		              +V  P +   L       +  + G +    +  +  +    M+ V      ++G   

		Sbjct: 239 HIRKVTDPFVDPGLGKNIPFMIGVLCGGIIFGTVAGFVSMVPYMMKDVHQLSTAEIGSVI 298

		

		Query: 309 LPANLIMAAFSLGLSARIVMRCGIRGPIAAGLLIAACGLALFSRAPVDGGFVWHVLPGMT 368

		           +    +       +   +V R G    +  G+   +      S    +    +  +  + 

		Sbjct: 299 IFPGTMSVIIFGYIGGILVDRRGPLYVLNIGVTFLSVSFLTASFLL-ETTSWFMTIIIVF 357

		

		Query: 369 LLGIGAGVAFNPVLLA--AMSDVEPADSGLASGIVNTAFMMGGALGLAVLASL 419

		           +LG   G++F   +++    S ++  ++G    ++N    +    G+A++  L

		Sbjct: 358 VLG---GLSFTKTVISTIVSSSLKQQEAGAGMSLLNFTSFLSEGTGIAIVGGL 407

		

		

		

		 Score = 32.5 bits (74), Expect = 0.003

		 Identities = 19/98 (19%), Positives = 34/98 (34%), Gaps = 1/98 (1%)

		

		Query: 66  LGGRLGDLYGQRRMFLAGLVVFTLASLACGVAPSQTLLIAARAVQG-FGGAVVSAVSLSL 124

		           +GG L D  G   +   G+   +++ L        T       +    GG   +   +S 

		Sbjct: 312 IGGILVDRRGPLYVLNIGVTFLSVSFLTASFLLETTSWFMTIIIVFVLGGLSFTKTVIST 371

		

		Query: 125 IMNLFTEPGERARAMGVYGFVCAGGGSLGVLLGGLLTS 162

		           I++   +  E    M +  F        G+ + G L S

		Sbjct: 372 IVSSSLKQQEAGAGMSLLNFTSFLSEGTGIAIVGGLLS 409

		

		

		>UREASE#Urea amidohydrolase (urease) protein signature.

		          Length = 570

		

		 Score = 31.6 bits (72), Expect = 0.005

		 Identities = 19/83 (22%), Positives = 31/83 (37%), Gaps = 19/83 (22%)

		

		Query: 19  RQADVFVADGKIAALGTAPAGFNADNT----------IDASGLIVAPGLVDLCARLREPG 68

		            +AD+ + DG+IAA+G A                   I   G IV  G +D       P 

		Sbjct: 84  VKADIGLKDGRIAAIGKAGNPDMQPGVTIIVGPGTEVIAGEGKIVTAGGMDSHIHFICP- 142

		

		Query: 69  YEHKATLASEMAAAVAGGVTTLV 91

		                    ++  A+  G+T ++

		Sbjct: 143 --------QQIEEALMSGLTCML 157

		

		

		>NUCEPIMERASE#Nucleotide sugar epimerase signature.

		          Length = 334

		

		 Score =  176 bits (449), Expect = 8e-55

		 Identities = 87/350 (24%), Positives = 136/350 (38%), Gaps = 43/350 (12%)

		

		Query: 2   ILVTGGAGFIGANFVIDWLRQSDEAVLNVDKLT--YAGNLRTL-QSLNGNPKHVFVRVDI 58

		            LVTG AGFIG +     L    + V+ +D L   Y  +L+     L   P   F ++D+

		Sbjct: 3   YLVTGAAGFIGFHVSKRLLEAGHQ-VVGIDNLNDYYDVSLKQARLELLAQPGFQFHKIDL 61

		

		Query: 59  CDRAALDALLAAHRPRAILHFAAESHVDRSIHGPAEFVQTNVVGTFTLLEAARQYWSALP 118

		            DR  +  L A+     +        V  S+  P  +  +N+ G   +LE  R       

		Sbjct: 62  ADREGMTDLFASGHFERVFISPHRLAVRYSLENPHAYADSNLTGFLNILEGCRHN----- 116

		

		Query: 119 GAEQAGFRFLHVSTDEVFGSLSATDPQFSETTPYA-PNSPYSATKAGSDHLVRAYHHTYG 177

		             +      L+ S+  V+G L+   P FS       P S Y+ATK  ++ +   Y H YG

		Sbjct: 117 KIQ----HLLYASSSSVYG-LNRKMP-FSTDDSVDHPVSLYAATKKANELMAHTYSHLYG 170

		

		Query: 178 LPTLTTNCSNNYGPYQFPEKLIPLMIANALAGKPLPVYGDGQNIRDWLYVGD---HCSAI 234

		           LP         YGP+  P+  +       L GK + VY  G+  RD+ Y+ D       +

		Sbjct: 171 LPATGLRFFTVYGPWGRPDMALFKFTKAMLEGKSIDVYNYGKMKRDFTYIDDIAEAIIRL 230

		

		Query: 235 REVLARGT---------------PGETYNVGGWNEMTNLDVVHTLCDLLDDARPRAQGTY 279

		           ++V+                   P   YN+G  + +  +D +  L D L      A    

		Sbjct: 231 QDVIPHADTQWTVETGTPAASIAPYRVYNIGNSSPVELMDYIQALEDALG---IEA---- 283

		

		Query: 280 RDHITYVKDRPGHDRRYAIDARKLERELGWKPAETFATGLAKTVAWYLDN 329

		                 +  +PG     + D + L   +G+ P  T   G+   V WY D 

		Sbjct: 284 --KKNMLPLQPGDVLETSADTKALYEVIGFTPETTVKDGVKNFVNWYRDF 331

		

		

		>NUCEPIMERASE#Nucleotide sugar epimerase signature.

		          Length = 334

		

		 Score = 48.2 bits (115), Expect = 1e-08

		 Identities = 54/258 (20%), Positives = 90/258 (34%), Gaps = 43/258 (16%)

		

		Query: 6   TILVTGVTGQVGFELLRSLQGLG-RVVACD-------------RSML-----------DL 40

		             LVTG  G +GF + + L   G +VV  D             R  L           DL

		Sbjct: 2   KYLVTGAAGFIGFHVSKRLLEAGHQVVGIDNLNDYYDVSLKQARLELLAQPGFQFHKIDL 61

		

		Query: 41  SDLDRIRAVVRALEPAFIVNPAAYTAVDNAEDDVDAARRINADVPRVLAEEAARSGAV-- 98

		           +D + +  +  +     +       AV  + ++  A    N      +  E  R   +  

		Sbjct: 62  ADREGMTDLFASGHFERVFISPHRLAVRYSLENPHAYADSNLTGFLNIL-EGCRHNKIQH 120

		

		Query: 99  LIHYSTDYVFDGAKAGAYTETDAVN-PLNVYGTTKLEGER----AIENAGCAYLTLRTSW 153

		           L++ S+  V+   +   ++  D+V+ P+++Y  TK   E          G     LR   

		Sbjct: 121 LLYASSSSVYGLNRKMPFSTDDSVDHPVSLYAATKKANELMAHTYSHLYGLPATGLRFFT 180

		

		Query: 154 VYGRRGR------NFLRTMLKLGAERPELRVVADQVGAPTWSKTIAAATAHILSKGLAAH 207

		           VYG  GR       F + ML+   +  ++          T+   IA A   +       H

		Sbjct: 181 VYGPWGRPDMALFKFTKAMLE--GKSIDVYNYGKMKRDFTYIDDIAEAIIRLQDV--IPH 236

		

		Query: 208 DEAWWQARSGTYHLSAAG 225

		            +  W   +GT   S A 

		Sbjct: 237 ADTQWTVETGTPAASIAP 254

		

		

		>ABC2TRNSPORT#ABC-2 type transport system membrane protein

		           signature.

		          Length = 262

		

		 Score = 28.7 bits (64), Expect = 0.027

		 Identities = 23/93 (24%), Positives = 44/93 (47%), Gaps = 5/93 (5%)

		

		Query: 176 PWTAILF--PVVMLP-LIVGSLGLAWFLSALGVYIRDISQITGVITSVLMFLSPVFYPVS 232

		            W ++L+  PV+ L  L   SLG+   ++AL            ++ + ++FLS   +PV 

		Sbjct: 143 QWLSLLYALPVIALTGLAFASLGM--VVTALAPSYDYFIFYQTLVITPILFLSGAVFPVD 200

		

		Query: 233 NLPPQYRSWIELNPLTFIIEEGRNTLIFGHLPD 265

		            LP  +++     PL+  I+  R  ++   + D

		Sbjct: 201 QLPIVFQTAARFLPLSHSIDLIRPIMLGHPVVD 233

		

		

		>SUBTILISIN#Subtilisin serine protease family (S8) signature.

		          Length = 326

		

		 Score = 52.2 bits (125), Expect = 1e-09

		 Identities = 24/122 (19%), Positives = 47/122 (38%), Gaps = 18/122 (14%)

		

		Query: 147 VHAIAPKAKI----VLVEAASASFTDLMAAVDVAVKRGASVVSMSFGGNEFFSGETAYDG 202

		           V  +AP+A +    VL +  S  +  ++  +  A+++   ++SMS GG E          

		Sbjct: 103 VVGVAPEADLLIIKVLNKQGSGQYDWIIQGIYYAIEQKVDIISMSLGGPEDVPELHEAVK 162

		

		Query: 203 HFNVPGVTFVASSGDSGTGTE------YPAASPYVVAVGGTTLSVDAAGNYVGEAAWSSS 256

		                 +  + ++G+ G G +      YP     V++VG               A+  S+

		Sbjct: 163 KAVASQILVMCAAGNEGDGDDRTDELGYPGCYNEVISVGAINFD--------RHASEFSN 214

		

		Query: 257 GG 258

		             

		Sbjct: 215 SN 216

		

		

		>ECOLNEIPORIN#E.coli/Neisseria porin superfamily signature.

		          Length = 331

		

		 Score =  126 bits (319), Expect = 1e-35

		 Identities = 91/388 (23%), Positives = 139/388 (35%), Gaps = 65/388 (16%)

		

		Query: 1   MKKTLIVAALAGIPAIAAHAQSSVTLYGLIDAGITYTNNQGGHSAW-----QETSGSING 55

		           MKK+LI   LA +P  A    + VTLYG I AG+  + +   + A        T     G

		Sbjct: 1   MKKSLIALTLAALPVAAM---ADVTLYGTIKAGVETSRSVAHNGAQAASVETGTGIVDLG 57

		

		Query: 56  SRWGLRGTEDLGGGLKAIFTLENGFGINNGTLKQNGREFGRQAFVGLAHDGFGSLTLGRQ 115

		           S+ G +G EDLG GLKAI+ +E    I       +     RQ+F+GL    FG L +GR 

		Sbjct: 58  SKIGFKGQEDLGNGLKAIWQVEQKASIAGT----DSGWGNRQSFIGLKGG-FGKLRVGRL 112

		

		Query: 116 YDSVVDYLG--PLSLTGTQYGGTEFAHPFDNDNLNNSFRINNAIKYQSVNYGGLKFGALY 173

		              + D     P        G  + A P   +    S      ++Y S  + GL     Y

		Sbjct: 113 NSVLKDTGDINPWDSKSDYLGVNKIAEP---EARLIS------VRYDSPEFAGLSGSVQY 163

		

		Query: 174 GFSNATNFANNRAYSVGASYSYLGFNVAAAYMQLNNNVNAPALAASDPGAVAGDWTFAAG 233

		             ++     N+ +Y  G +Y   GF V        ++                       

		Sbjct: 164 ALNDNAGRHNSESYHAGFNYKNGGFFVQYGGAYKRHHQ--------------VQENVNIE 209

		

		Query: 234 RQRTWGAGLNYGFGPATAGFVFTQTRLTDSAGISAGQSGVSR-GIALTGGTRFNNYEVNG 292

		           + +       Y      A +     +  D+  +    S  S+  +A T   RF N     

		Sbjct: 210 KYQIHRLVSGYD---NDALYASVAVQQQDAKLVEENYSHNSQTEVAATLAYRFGNV---- 262

		

		Query: 293 RYALTPAFSLAGSYTYTDARLDGQSPSWHQFNLQADYALSKRTDLYLQGEYQRVNADGLA 352

		              ++ A    GS+  T       +  + Q  + A+Y  SKRT   +   + +       

		Sbjct: 263 TPRVSYAHGFKGSFDAT-----NYNNDYDQVVVGAEYDFSKRTSALVSAGWLQEG----- 312

		

		Query: 353 IGANINGLGSASSTNKQIAVTAGMRHRF 380

		                 G     ST    A   G+RH+F

		Sbjct: 313 -----KGESKFVST----AGGVGLRHKF 331

		

		

		>PF03544#Gram-negative bacterial tonB protein

		          Length = 243

		

		 Score = 28.4 bits (63), Expect = 0.050

		 Identities = 13/105 (12%), Positives = 20/105 (19%), Gaps = 10/105 (9%)

		

		Query: 3   ETTPSPAGLPGTFSASPDSRRSEPPRAADVPAAPAAQAAAAHDVADDGASPVTAASEPGA 62

		              P P   P            E P+    P     +         D     +  + P  

		Sbjct: 73  VVEPEPEPEPIPEPPKEAPVVIEKPKPKPKPKPKPVKKVEQ--PKRDVKPVESRPASPFE 130

		

		Query: 63  AGTPGAAGEAAPPKPGAAPPGFGAQPDFDTPRPPPASAQNAPPAY 107

		              P     +      + P               P +     P Y

		Sbjct: 131 NTAPARPTSSTATAATSKPVTS--------VASGPRALSRNQPQY 167

		

		

		>RTXTOXIND#Gram-negative bacterial RTX secretion protein D

		           signature.

		          Length = 478

		

		 Score = 31.3 bits (71), Expect = 0.003

		 Identities = 18/140 (12%), Positives = 44/140 (31%), Gaps = 22/140 (15%)

		

		Query: 108 FQDKQLWRVIKSQDKSRAQMVY-ENFVQQTAQLADVELRRTELQAQKAFLERMIALQANR 166

		             D+  ++ +  ++  R   +  E F     Q    EL   + +A++  +   I    N 

		Sbjct: 170 LPDEPYFQNVSEEEVLRLTSLIKEQFSTWQNQKYQKELNLDKKRAERLTVLARINRYENL 229

		

		Query: 167 AQQLQADLSIARS--------------QQAEVAQ-RQRSAREQAQALQVEKRAAQLQLR- 210

		           ++  ++ L    S              Q+ +  +        ++Q  Q+E      +   

		Sbjct: 230 SRVEKSRLDDFSSLLHKQAIAKHAVLEQENKYVEAVNELRVYKSQLEQIESEILSAKEEY 289

		

		Query: 211 -----DLQKQVRQLERQAEM 225

		                  + ++    RQ   

		Sbjct: 290 QLVTQLFKNEILDKLRQTTD 309

		

		

		

		 Score = 30.6 bits (69), Expect = 0.005

		 Identities = 15/94 (15%), Positives = 36/94 (38%), Gaps = 2/94 (2%)

		

		Query: 134 QQTAQLADVELRRTELQAQKAFLERMIALQA-NRAQQLQADLSIARSQQAEVAQRQRSAR 192

		           +  +++    L        K  + +   L+  N+  +   +L + +SQ  ++     SA+

		Sbjct: 227 ENLSRVEKSRLDDFSSLLHKQAIAKHAVLEQENKYVEAVNELRVYKSQLEQIESEILSAK 286

		

		Query: 193 EQAQALQVEKRAAQL-QLRDLQKQVRQLERQAEM 225

		           E+ Q +    +   L +LR     +  L  +   

		Sbjct: 287 EEYQLVTQLFKNEILDKLRQTTDNIGLLTLELAK 320

		

		

		>TCRTETA#Tetracycline resistance protein signature.

		          Length = 399

		

		 Score = 33.3 bits (76), Expect = 0.002

		 Identities = 34/196 (17%), Positives = 60/196 (30%), Gaps = 27/196 (13%)

		

		Query: 239 VVIAGMGMVIMTTVSFYMITAYTPTFGKEVLHLSSLDALVVTVCVGLSNLVWLPLSGALS 298

		           V +  +G+ ++  V   ++     +      H   L A        L      P+ GALS

		Sbjct: 14  VALDAVGIGLIMPVLPGLLRDLVHS-NDVTAHYGILLA-----LYALMQFACAPVLGALS 67

		

		Query: 299 DRIGRRPVLIAFTVLTLLSAYPAVQWLVGEPSFLRLLAVELWLSFLYGSYNGAMVVALTE 358

		           DR GRRPVL+       +        ++    FL +L +   ++ + G+        + +

		Sbjct: 68  DRFGRRPVLLVSLAGAAVDYA-----IMATAPFLWVLYIGRIVAGITGATGAVAGAYIAD 122

		

		Query: 359 VMPADVRT-------AGFSLAYSLATTIGGFTPAISTLLIHETGNKAAPGLWLSVAAICG 411

		           +   D R        A F         +GG     S           AP    +      

		Sbjct: 123 ITDGDERARHFGFMSACFGFGMVAGPVLGGLMGGFSP---------HAPFFAAAALNGLN 173

		

		Query: 412 LIATLVLYRTPEARNQ 427

		            +    L        +

		Sbjct: 174 FLTGCFLLPESHKGER 189

		

		

		>SYCDCHAPRONE#Gram-negative bacterial type III secretion SycD

		           chaperone signature.

		          Length = 168

		

		 Score = 51.1 bits (122), Expect = 1e-09

		 Identities = 21/112 (18%), Positives = 39/112 (34%), Gaps = 3/112 (2%)

		

		Query: 9   LSVSSSVMDSAFDRAYAAHRAGRLAEAEHGYRAALATNPADADALHLFGVLRHQQGQHAE 68

		             +SS  ++  +  A+  +++G+  +A   ++A    +  D+      G  R   GQ+  

		Sbjct: 29  NEISSDTLEQLYSLAFNQYQSGKYEDAHKVFQALCVLDHYDSRFFLGLGACRQAMGQYDL 88

		

		Query: 69  AADLVGRAVELRPGDAALQLNLGNALKALGRLDEAIDRFRNALTLA---PEF 117

		           A         +   +     +    L   G L EA      A  L     EF

		Sbjct: 89  AIHSYSYGAIMDIKEPRFPFHAAECLLQKGELAEAESGLFLAQELIADKTEF 140

		

		

		

		 Score = 48.0 bits (114), Expect = 1e-08

		 Identities = 18/101 (17%), Positives = 36/101 (35%)

		

		Query: 47  PADADALHLFGVLRHQQGQHAEAADLVGRAVELRPGDAALQLNLGNALKALGRLDEAIDR 106

		               + L+     ++Q G++ +A  +      L   D+   L LG   +A+G+ D AI  

		Sbjct: 33  SDTLEQLYSLAFNQYQSGKYEDAHKVFQALCVLDHYDSRFFLGLGACRQAMGQYDLAIHS 92

		

		Query: 107 FRNALTLAPEFPLAHYNLGNAYAALQRHEDAVDAFGRALRL 147

		           +     +  + P   ++            +A      A  L

		Sbjct: 93  YSYGAIMDIKEPRFPFHAAECLLQKGELAEAESGLFLAQEL 133

		

		

		

		 Score = 41.8 bits (98), Expect = 2e-06

		 Identities = 20/105 (19%), Positives = 34/105 (32%)

		

		Query: 145 LRLTPDDASIHNNLGNALNALGRHDDALAAFHRALELRPGHAGAHNNLAMALNAMGRAND 204

		             ++ D      +L       G+++DA   F     L    +     L     AMG+ + 

		Sbjct: 29  NEISSDTLEQLYSLAFNQYQSGKYEDAHKVFQALCVLDHYDSRFFLGLGACRQAMGQYDL 88

		

		Query: 205 AIAHFQAALAAEPRFVAAHFNLGNTFEALGRHAEAAAAFEAALAL 249

		           AI  +      + +     F+        G  AEA +    A  L

		Sbjct: 89  AIHSYSYGAIMDIKEPRFPFHAAECLLQKGELAEAESGLFLAQEL 133

		

		

		

		 Score = 41.8 bits (98), Expect = 2e-06

		 Identities = 17/74 (22%), Positives = 27/74 (36%)

		

		Query: 191 NLAMALNAMGRANDAIAHFQAALAAEPRFVAAHFNLGNTFEALGRHAEAAAAFEAALALH 250

		           +LA      G+  DA   FQA    +         LG   +A+G++  A  ++     + 

		Sbjct: 41  SLAFNQYQSGKYEDAHKVFQALCVLDHYDSRFFLGLGACRQAMGQYDLAIHSYSYGAIMD 100

		

		Query: 251 PPFPLALFGLANAL 264

		              P   F  A  L

		Sbjct: 101 IKEPRFPFHAAECL 114

		

		

		

		 Score = 41.1 bits (96), Expect = 3e-06

		 Identities = 20/81 (24%), Positives = 35/81 (43%)

		

		Query: 257 LFGLANALSAQGRHRDALPCYERAVGLDPSFSLAWLNLGNAHHALGAHEMALRAFDQALR 316

		           L+ LA      G++ DA   ++    LD   S  +L LG    A+G +++A+ ++     

		Sbjct: 39  LYSLAFNQYQSGKYEDAHKVFQALCVLDHYDSRFFLGLGACRQAMGQYDLAIHSYSYGAI 98

		

		Query: 317 VAPDLTLARLHRAVTLLTLGD 337

		           +         H A  LL  G+

		Sbjct: 99  MDIKEPRFPFHAAECLLQKGE 119

		

		

		

		 Score = 40.7 bits (95), Expect = 4e-06

		 Identities = 21/127 (16%), Positives = 41/127 (32%), Gaps = 9/127 (7%)

		

		Query: 102 EAIDRFRNALTLA------PEFPLAHYNLGNAYAALQRHEDAVDAFGRALRLTPDDASIH 155

		                 +   T+A       +     Y+L        ++EDA   F     L   D+   

		Sbjct: 14  AMESFLKGGGTIAMLNEISSDTLEQLYSLAFNQYQSGKYEDAHKVFQALCVLDHYDSRFF 73

		

		Query: 156 NNLGNALNALGRHDDALAAFHRALELRPGHAGAHNNLA---MALNAMGRANDAIAHFQAA 212

		             LG    A+G++D A+ ++     +         + A   +    +  A   +   Q  

		Sbjct: 74  LGLGACRQAMGQYDLAIHSYSYGAIMDIKEPRFPFHAAECLLQKGELAEAESGLFLAQEL 133

		

		Query: 213 LAAEPRF 219

		           +A +  F

		Sbjct: 134 IADKTEF 140

		

		

		>PF07520#Virulence protein SrfB

		          Length = 1041

		

		 Score = 25.7 bits (56), Expect = 0.044

		 Identities = 12/37 (32%), Positives = 15/37 (40%), Gaps = 10/37 (27%)

		

		Query: 68  TLWDELARPTPPPAPLPLP------VDTQHAMAGGTT 98

		           T  D   +P P PA    P      +D    + GGTT

		Sbjct: 575 TFLDLKGQPRPDPAGGESPSLRLACID----VGGGTT 607

		

		

		>HTHFIS#FIS bacterial regulatory protein HTH signature.

		          Length = 484

		

		 Score =  369 bits (949), Expect = e-126

		 Identities = 134/386 (34%), Positives = 198/386 (51%), Gaps = 43/386 (11%)

		

		Query: 101 FDYVTMPYETARIVETVGHAHGMIALADAAATAAAPVGAGRSEGEMVGTCDAMLGLFRTI 160

		           +DY+  P++   ++  +G A     LA+     +      +    +VG   AM  ++R +

		Sbjct: 99  YDYLPKPFDLTELIGIIGRA-----LAEPKRRPSKLEDDSQDGMPLVGRSAAMQEIYRVL 153

		

		Query: 161 RRVATTDAPVFISGESGTGKELTAAAIHERSTRAPGPFVAINCGAIPSTLLQAELFGYER 220

		            R+  TD  + I+GESGTGKEL A A+H+   R  GPFVAIN  AIP  L+++ELFG+E+

		Sbjct: 154 ARLMQTDLTLMITGESGTGKELVARALHDYGKRRNGPFVAINMAAIPRDLIESELFGHEK 213

		

		Query: 221 GAFTGATQRKVGRVEAANGGTLFLDEIGDLPFESQASLLRFLQEGKIERLGAHVSVPVDV 280

		           GAFTGA  R  GR E A GGTLFLDEIGD+P ++Q  LLR LQ+G+   +G    +  DV

		Sbjct: 214 GAFTGAQTRSTGRFEQAEGGTLFLDEIGDMPMDAQTRLLRVLQQGEYTTVGGRTPIRSDV 273

		

		Query: 281 RVICATHVDMEAALREGRFREDLYHRLCVLKIEEPPLRARGKDIELLARHMLERFKGDAH 340

		           R++ AT+ D++ ++ +G FREDLY+RL V+ +  PPLR R +DI  L RH +++ + +  

		Sbjct: 274 RIVAATNKDLKQSINQGLFREDLYYRLNVVPLRLPPLRDRAEDIPDLVRHFVQQAEKEG- 332

		

		Query: 341 RRLRGFSPDAIAALYGYAWPGNVRELINRVRRAIVMSEGRMITAADLELN---------- 390

		             ++ F  +A+  +  + WPGNVREL N VRR   +    +IT   +E            

		Sbjct: 333 LDVKRFDQEALELMKAHPWPGNVRELENLVRRLTALYPQDVITREIIENELRSEIPDSPI 392

		

		Query: 391 ---------------------------EFAVLAPVSLNEAREAAERQAIEQALLRHRGRF 423

		                                        A+      +      E   I  AL   RG  

		Sbjct: 393 EKAAARSGSLSISQAVEENMRQYFASFGDALPPSGLYDRVLAEMEYPLILAALTATRGNQ 452

		

		Query: 424 ADAARELGVSRVTLYRLMCAHGMRDR 449

		             AA  LG++R TL + +   G+   

		Sbjct: 453 IKAADLLGLNRNTLRKKIRELGVSVY 478

		

		

		>IGASERPTASE#IgA-specific serine endopeptidase (S6) signature.

		          Length = 1541

		

		 Score = 38.5 bits (89), Expect = 1e-04

		 Identities = 38/233 (16%), Positives = 62/233 (26%), Gaps = 28/233 (12%)

		

		Query: 609  RTPNAAAPNAAHFANGAAAQAPGPAQHQAVGAGNGVPHPPTAGNSPAAHDGAHAAAAPAP 668

		             T N   PN        A     P+ ++ +   +  P PP A  +P+      A  +   

		Sbjct: 993  DTTNITTPNNIQ-----ADVPSVPSNNEEIARVDEAPVPPPAPATPSETTETVAENSKQ- 1046

		

		Query: 669  VWMQPHTPMDRQRPNPPTALHAAGQNALPPVRAAAPTPRPQTPAGAQPGERQPTPHEAPQ 728

		                     + Q     TA     QN     R  A   +    A  Q  E   +  E  +

		Sbjct: 1047 --ESKTVEKNEQDATETTA-----QN-----REVAKEAKSNVKANTQTNEVAQSGSETKE 1094

		

		Query: 729  PRFDTSAQMQQPRPHADFAAPAQHGQPRAERPAPAPQPRADFAQPAPHREVAPPHVSEYR 788

		                   Q  + +  A      +  +   E+    P+  +  +      E   P     R

		Sbjct: 1095 ------TQTTETKETATVEK-EEKAKVETEKTQEVPKVTSQVSPKQEQSETVQPQAEPAR 1147

		

		Query: 789  PPAPVVHEMPRPQPAPRMEPRPSMPAPHVEPRPQPAPHVEAPHPSNPPPAAHE 841

		               P V+     +P  +         P  E        V      N   +  E

		Sbjct: 1148 ENDPTVNI---KEPQSQTNTTADTEQPAKETSSNVEQPVTESTTVNTGNSVVE 1197

		

		

		>AUTOINDCRSYN#Autoinducer synthesis protein signature.

		          Length = 216

		

		 Score = 36.7 bits (85), Expect = 4e-05

		 Identities = 23/139 (16%), Positives = 42/139 (30%), Gaps = 10/139 (7%)

		

		Query: 43  TEDELREAQRLRYTVFAEEMGAQVSGPSGLDVDPFDAYCDHLLVRDLDTLKVVGTYRVLP 102

		           +E +  E   LR   F + +   V    G++ D +D      L    D   V+ + R + 

		Sbjct: 13  SETKSGELFTLRKETFKDRLNWAVQCTDGMEFDQYDNNNTTYLFGIKDN-TVICSLRFIE 71

		

		Query: 103 PHQAARVGRLYAEGEFDLSRLTHLRGKMVEVGRSCVHSDY------RSGAVIMALWGGLG 156

		                 +   +         +    G  +E  R  V              +   L+  + 

		Sbjct: 72  TKYPNMITGTFFP---YFKEINIPEGNYLESSRFFVDKSRAKDILGNEYPISSMLFLSMI 128

		

		Query: 157 AYMMQNGYETMLGCASVSM 175

		            Y    GY+ +    S  M

		Sbjct: 129 NYSKDKGYDGIYTIVSHPM 147

		

		

		>RTXTOXIND#Gram-negative bacterial RTX secretion protein D

		           signature.

		          Length = 478

		

		 Score = 29.4 bits (66), Expect = 0.014

		 Identities = 13/71 (18%), Positives = 31/71 (43%), Gaps = 14/71 (19%)

		

		Query: 140 SAGTPV--QAAATGTVVYAGNGLRGYGNLIILKHNADYLTAYAHNRALLVREGQSVTQGQ 197

		           S    V   A A G + ++G           +K   + +      + ++V+EG+SV +G 

		Sbjct: 75  SVLGQVEIVATANGKLTHSGR-------SKEIKPIENSIV-----KEIIVKEGESVRKGD 122

		

		Query: 198 TIAEMGSSDSD 208

		            + ++ +  ++

		Sbjct: 123 VLLKLTALGAE 133

		

		

		>SECA#SecA protein signature.

		          Length = 901

		

		 Score = 27.1 bits (60), Expect = 0.048

		 Identities = 17/53 (32%), Positives = 25/53 (47%), Gaps = 5/53 (9%)

		

		Query: 112 NELRTRADALVAAEAELKSKTDELDERLAGLVTRENDLLARVQAFEAEQEAAK 164

		           N +    + L  ++ ELK KT E   RL      EN +    +AF   +EA+K

		Sbjct: 29  NAMEPEMEKL--SDEELKGKTAEFRARLEKGEVLENLI---PEAFAVVREASK 76

		

		

		>HTHFIS#FIS bacterial regulatory protein HTH signature.

		          Length = 484

		

		 Score = 26.7 bits (59), Expect = 0.019

		 Identities = 10/60 (16%), Positives = 22/60 (36%), Gaps = 2/60 (3%)

		

		Query: 1   MSTSDTSKKAAEDWDKADIKHALEKKGWNIRRLANACGYSNSSALRKA--FDSSYPKAER 58

		           +  S    +   + +   I  AL     N  + A+  G + ++  +K      S  ++ R

		Sbjct: 423 LPPSGLYDRVLAEMEYPLILAALTATRGNQIKAADLLGLNRNTLRKKIRELGVSVYRSSR 482

		

		

		>PF03544#Gram-negative bacterial tonB protein

		          Length = 243

		

		 Score = 40.3 bits (94), Expect = 8e-06

		 Identities = 17/77 (22%), Positives = 21/77 (27%), Gaps = 2/77 (2%)

		

		Query: 199 RAPAPVAPAAAVAPAPAPAPAASAVPAAHTPAAA--VTPAAVPATAAPAPTAPATAAPAP 256

		             P P   A  V   P P P     P          V P      +    TAPA    + 

		Sbjct: 82  PIPEPPKEAPVVIEKPKPKPKPKPKPVKKVEQPKRDVKPVESRPASPFENTAPARPTSST 141

		

		Query: 257 TAPAPTAPAPTAPPDAR 273

		              A + P  +     R

		Sbjct: 142 ATAATSKPVTSVASGPR 158

		

		

		

		 Score = 35.0 bits (80), Expect = 4e-04

		 Identities = 16/76 (21%), Positives = 19/76 (25%), Gaps = 3/76 (3%)

		

		Query: 201 PAPVAPAAAVAPAPAPAPAASAVPAAHTPAAAVTPAAVPATAAPAPTAPATAAPAPTAPA 260

		           PAP  P +    APA         A   P   V          P P   A        P 

		Sbjct: 44  PAPAQPISVTMVAPADLEP---PQAVQPPPEPVVEPEPEPEPIPEPPKEAPVVIEKPKPK 100

		

		Query: 261 PTAPAPTAPPDARRRR 276

		           P           + +R

		Sbjct: 101 PKPKPKPVKKVEQPKR 116

		

		

		

		 Score = 34.2 bits (78), Expect = 7e-04

		 Identities = 17/75 (22%), Positives = 20/75 (26%), Gaps = 4/75 (5%)

		

		Query: 200 APAPVAPAAAVAPAPAPA--PAASAVPAAHTPAAAVTPAAVPATAAPAPTAPATAAPAPT 257

		           APA + P  AV P P P   P     P    P  A  P  +          P        

		Sbjct: 56  APADLEPPQAVQPPPEPVVEPEPEPEPIPEPPKEA--PVVIEKPKPKPKPKPKPVKKVEQ 113

		

		Query: 258 APAPTAPAPTAPPDA 272

		                 P  + P   

		Sbjct: 114 PKRDVKPVESRPASP 128

		

		

		>DHBDHDRGNASE#2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase

		           signature.

		          Length = 261

		

		 Score = 94.7 bits (235), Expect = 2e-25

		 Identities = 73/254 (28%), Positives = 121/254 (47%), Gaps = 14/254 (5%)

		

		Query: 4   LAGKVAIVTGASKGIGAAIAKALAAEGASVV-VNYASSKAGADAVVGAIVEAGGRAVAVG 62

		           + GK+A +TGA++GIG A+A+ LA++GA +  V+Y   K   + VV ++      A A  

		Sbjct: 6   IEGKIAFITGAAQGIGEAVARTLASQGAHIAAVDYNPEKL--EKVVSSLKAEARHAEAFP 63

		

		Query: 63  GDVSKGADAQRIVDTAIETYGRLDVLVNNSGVYEFAPIEAITEAHYRRQFDTNVFGLLLT 122

		            DV   A    I        G +D+LVN +GV     I ++++  +   F  N  G+   

		Sbjct: 64  ADVRDSAAIDEITARIEREMGPIDILVNVAGVLRPGLIHSLSDEEWEATFSVNSTGVFNA 123

		

		Query: 123 TQAAVKHL--GEGASIINISSVVTSITPPASAVYSGTKGAVDAITGVLALELGARKIRVN 180

		           +++  K++      SI+ + S    +   + A Y+ +K A    T  L LEL    IR N

		Sbjct: 124 SRSVSKYMMDRRSGSIVTVGSNPAGVPRTSMAAYASSKAAAVMFTKCLGLELAEYNIRCN 183

		

		Query: 181 AINPGMIVTEGTHAAGITGSDLEAQVLSQT--------PLGRLGEPNDIASVAVFLASDD 232

		            ++PG   T+   +      +   QV+  +        PL +L +P+DIA   +FL S  

		Sbjct: 184 IVSPGSTETDMQWSLW-ADENGAEQVIKGSLETFKTGIPLKKLAKPSDIADAVLFLVSGQ 242

		

		Query: 233 ARWMTGEHVVVSGG 246

		           A  +T  ++ V GG

		Sbjct: 243 AGHITMHNLCVDGG 256

		

		

		>HTHTETR#TetR bacterial regulatory protein HTH signature.

		          Length = 215

		

		 Score =  105 bits (262), Expect = 4e-30

		 Identities = 45/182 (24%), Positives = 88/182 (48%), Gaps = 3/182 (1%)

		

		Query: 1   MARKTREESLAIKHRILDAAELVLLEQGVAQTAMADLAEAAGMSRGAVYGHYRNKMEVCL 60

		           MARKT++E+   +  ILD A  +  +QGV+ T++ ++A+AAG++RGA+Y H+++K ++  

		Sbjct: 1   MARKTKQEAQETRQHILDVALRLFSQQGVSSTSLGEIAKAAGVTRGAIYWHFKDKSDLFS 60

		

		Query: 61  ALCDRAFARTSEGFEAADGLPA---FATLRRAASHYLRQCGEPGSMQRVLVILYTKCEQS 117

		            + + + +   E              + LR    H L         + ++ I++ KCE  

		Sbjct: 61  EIWELSESNIGELELEYQAKFPGDPLSVLREILIHVLESTVTEERRRLLMEIIFHKCEFV 120

		

		Query: 118 EENGALLRRRTLLELQILRITKALLRRAIAGGELAADLDVHLAAVYLVSLLEGVFASMIW 177

		            E   + + +  L L+     +  L+  I    L ADL    AA+ +   + G+  + ++

		Sbjct: 121 GEMAVVQQAQRNLCLESYDRIEQTLKHCIEAKMLPADLMTRRAAIIMRGYISGLMENWLF 180

		

		Query: 178 TD 179

		             

		Sbjct: 181 AP 182

		

		

		>RTXTOXIND#Gram-negative bacterial RTX secretion protein D

		           signature.

		          Length = 478

		

		 Score = 38.3 bits (89), Expect = 5e-05

		 Identities = 20/133 (15%), Positives = 42/133 (31%), Gaps = 5/133 (3%)

		

		Query: 69  EVRARVAGIVTARTYDEGQEVKQGAVLFRIDSAPLKAARDAAQGALAKAQAAALAATDKR 128

		           E++     IV      EG+ V++G VL ++ +   +A     Q +L +A+          

		Sbjct: 98  EIKPIENSIVKEIIVKEGESVRKGDVLLKLTALGAEADTLKTQSSLLQARLEQTRYQILS 157

		

		Query: 129 RRYDDLVRDRAVSERDLTEAVAADTQARAEVVSAKAELA-----RAQLQLDYATVTAPIA 183

		           R  +           +      ++ +        K + +     + Q +L+     A   

		Sbjct: 158 RSIELNKLPELKLPDEPYFQNVSEEEVLRLTSLIKEQFSTWQNQKYQKELNLDKKRAERL 217

		

		Query: 184 GRARRALVTEGAL 196

		               R    E   

		Sbjct: 218 TVLARINRYENLS 230

		

		

		

		 Score = 34.4 bits (79), Expect = 6e-04

		 Identities = 14/101 (13%), Positives = 39/101 (38%), Gaps = 10/101 (9%)

		

		Query: 103 LKAARDAAQGALAKAQAAALAATDKRRRYDDLVRDRAVSERDLTEAVAADTQARAEVVSA 162

		                   +  L + ++  L+A ++ +    L ++  + +           Q    +   

		Sbjct: 264 AVNELRVYKSQLEQIESEILSAKEEYQLVTQLFKNEILDKL---------RQTTDNIGLL 314

		

		Query: 163 KAELARAQLQLDYATVTAPIAGR-ARRALVTEGALVGQDQA 202

		             ELA+ + +   + + AP++ +  +  + TEG +V   + 

		Sbjct: 315 TLELAKNEERQQASVIRAPVSVKVQQLKVHTEGGVVTTAET 355

		

		

		>ACRIFLAVINRP#Acriflavin resistance protein family signature.

		          Length = 1034

		

		 Score = 1062 bits (2748), Expect = 0.0

		 Identities = 523/1032 (50%), Positives = 714/1032 (69%), Gaps = 6/1032 (0%)

		

		Query: 1    MARFFIDRPVFAWVIALFILLGGGFAIRALPVAQYPDIAPPVVSIYASYPGASAQVVEES 60

		            MA FFI RP+FAWV+A+ +++ G  AI  LPVAQYP IAPP VS+ A+YPGA AQ V+++

		Sbjct: 1    MANFFIRRPIFAWVLAIILMMAGALAILQLPVAQYPTIAPPAVSVSANYPGADAQTVQDT 60

		

		Query: 61   VTALIEREMNGAPGLLY-TSASSSAGSASLYLTFKQGVNADLAAVEVQNRLKTVDARLPE 119

		            VT +IE+ MNG   L+Y +S S SAGS ++ LTF+ G + D+A V+VQN+L+     LP+

		Sbjct: 61   VTQVIEQNMNGIDNLMYMSSTSDSAGSVTITLTFQSGTDPDIAQVQVQNKLQLATPLLPQ 120

		

		Query: 120  PVRRAGIQVEKAADNIQLVVSLTSDDGRMTDVQLGEYASANVVQALRRVDGVGRVQFWGA 179

		             V++ GI VEK++ +  +V    SD+   T   + +Y ++NV   L R++GVG VQ +GA

		Sbjct: 121  EVQQQGISVEKSSSSYLMVAGFVSDNPGTTQDDISDYVASNVKDTLSRLNGVGDVQLFGA 180

		

		Query: 180  EYAMRIWPDPDKLAGHGVTASDIASAVRAHNARVTIGDIGRSAVPDSAPIAATVFADAPL 239

		            +YAMRIW D D L  + +T  D+ + ++  N ++  G +G +       + A++ A    

		Sbjct: 181  QYAMRIWLDADLLNKYKLTPVDVINQLKVQNDQIAAGQLGGTPALPGQQLNASIIAQTRF 240

		

		Query: 240  KTPADFGAIALRTQPDGSALYLRDVARVEFGGNDYNYPSYVNGKVATGMGIKLAPGSNAV 299

		            K P +FG + LR   DGS + L+DVARVE GG +YN  + +NGK A G+GIKLA G+NA+

		Sbjct: 241  KNPEEFGKVTLRVNSDGSVVRLKDVARVELGGENYNVIARINGKPAAGLGIKLATGANAL 300

		

		Query: 300  ATERRVRAAMDELSAYFPPGVKYQIPYETSSFVRVSMNKVVTTLIEAGVLVFLVMFLFMQ 359

		             T + ++A + EL  +FP G+K   PY+T+ FV++S+++VV TL EA +LVFLVM+LF+Q

		Sbjct: 301  DTAKAIKAKLAELQPFFPQGMKVLYPYDTTPFVQLSIHEVVKTLFEAIMLVFLVMYLFLQ 360

		

		Query: 360  NLRATLIPTLVVPVALAGTFGVMQALGFSINVLTMFGMVLAIGILVDDAIVVVENVERLM 419

		            N+RATLIPT+ VPV L GTF ++ A G+SIN LTMFGMVLAIG+LVDDAIVVVENVER+M

		Sbjct: 361  NMRATLIPTIAVPVVLLGTFAILAAFGYSINTLTMFGMVLAIGLLVDDAIVVVENVERVM 420

		

		Query: 420  VEERLEPYEATVKAMQQISGAIVGITVVLTSVFVPMAFFGGAVGNIYRQFALALAVSIAF 479

		            +E++L P EAT K+M QI GA+VGI +VL++VF+PMAFFGG+ G IYRQF++ +  ++A 

		Sbjct: 421  MEDKLPPKEATEKSMSQIQGALVGIAMVLSAVFIPMAFFGGSTGAIYRQFSITIVSAMAL 480

		

		Query: 480  SAFLALSLTPALCATLLKPVDGGHHD-KRGFFGAFNRFVARATQRYATRVGTMLARPLRW 538

		            S  +AL LTPALCATLLKPV   HH+ K GFFG FN     +   Y   VG +L    R+

		Sbjct: 481  SVLVALILTPALCATLLKPVSAEHHENKGGFFGWFNTTFDHSVNHYTNSVGKILGSTGRY 540

		

		Query: 539  LVVYGALTAAAVLMLTQLPSAFLPDEDQGNFMVMVIRPQGTPLAETMRSVREV-DAYLRR 597

		            L++Y  + A  V++  +LPS+FLP+EDQG F+ M+  P G     T + + +V D YL+ 

		Sbjct: 541  LLIYALIVAGMVVLFLRLPSSFLPEEDQGVFLTMIQLPAGATQERTQKVLDQVTDYYLKN 600

		

		Query: 598  EEPAAY-TFALGGFNLYGEGPNGGMIFVSLKDWRARKAARDHVQAIVARINARFAGTPNT 656

		            E+      F + GF+  G+  N GM FVSLK W  R    +  +A++ R         + 

		Sbjct: 601  EKANVESVFTVNGFSFSGQAQNAGMAFVSLKPWEERNGDENSAEAVIHRAKMELGKIRDG 660

		

		Query: 657  TVFAMNAPALPYLGSTSGFDFRLQNRGGLDYAAFSAAREQLLAAAGRDPA-LTDVMFAGM 715

		             V   N PA+  LG+ +GFDF L ++ GL + A + AR QLL  A + PA L  V   G+

		Sbjct: 661  FVIPFNMPAIVELGTATGFDFELIDQAGLGHDALTQARNQLLGMAAQHPASLVSVRPNGL 720

		

		Query: 716  QDAPQLKLDVDRAKASALGVSMDEINTTLAVMFGSDYIGDFMHGTQVRRVIVQADGQHRV 775

		            +D  Q KL+VD+ KA ALGVS+ +IN T++   G  Y+ DF+   +V+++ VQAD + R+

		Sbjct: 721  EDTAQFKLEVDQEKAQALGVSLSDINQTISTALGGTYVNDFIDRGRVKKLYVQADAKFRM 780

		

		Query: 776  DPDDVKKLRVRNARGEMVPLAAFTTLHWTLGPPQLTRYNGFPSFTINGSAAPGHSSGEAM 835

		             P+DV KL VR+A GEMVP +AFTT HW  G P+L RYNG PS  I G AAPG SSG+AM

		Sbjct: 781  LPEDVDKLYVRSANGEMVPFSAFTTSHWVYGSPRLERYNGLPSMEIQGEAAPGTSSGDAM 840

		

		Query: 836  AALERLAATLPAGIGHAWSGQSFEERLSGAQAPMLFALSVLVVFLALAALYESWSIPFAV 895

		            A +E LA+ LPAGIG+ W+G S++ERLSG QAP L A+S +VVFL LAALYESWSIP +V

		Sbjct: 841  ALMENLASKLPAGIGYDWTGMSYQERLSGNQAPALVAISFVVVFLCLAALYESWSIPVSV 900

		

		Query: 896  MLVVPLGVIGAVLGVTLRAMPNDIYFKVGLIATIGLSAKNAILIVEVAKDLVAQR-MPLI 954

		            MLVVPLG++G +L  TL    ND+YF VGL+ TIGLSAKNAILIVE AKDL+ +    ++

		Sbjct: 901  MLVVPLGIVGVLLAATLFNQKNDVYFMVGLLTTIGLSAKNAILIVEFAKDLMEKEGKGVV 960

		

		Query: 955  DAAREAARLRLRPIVMTSLAFGVGVLPLAFASGAASGAQMAIGTGVLGGVITATVLAVFL 1014

		            +A   A R+RLRPI+MTSLAF +GVLPLA ++GA SGAQ A+G GV+GG+++AT+LA+F 

		Sbjct: 961  EATLMAVRMRLRPILMTSLAFILGVLPLAISNGAGSGAQNAVGIGVMGGMVSATLLAIFF 1020

		

		Query: 1015 VPLFFVMVGRVF 1026

		            VP+FFV++ R F

		Sbjct: 1021 VPVFFVVIRRCF 1032

		

		

		>PF05272#Virulence-associated E family protein

		          Length = 892

		

		 Score = 28.9 bits (64), Expect = 0.031

		 Identities = 12/23 (52%), Positives = 13/23 (56%)

		

		Query: 35  VTALCGPNGCGKSTLLRTLAGLQ 57

		              L G  G GKSTL+ TL GL 

		Sbjct: 598 SVVLEGTGGIGKSTLINTLVGLD 620

		

		

		>2FE2SRDCTASE#Ferric iron reductase signature.

		          Length = 262

		

		 Score = 74.3 bits (182), Expect = 8e-18

		 Identities = 53/204 (25%), Positives = 82/204 (40%), Gaps = 18/204 (8%)

		

		Query: 58  ALLDAMVRHYGGDP---ARHARALISQWSKYYFGRAAPAAVAAALTLGRPLDMAPRRTFV 114

		           +LL     H   +     R  + LIS W+++Y G   P  + A LT  + LD++P     

		Sbjct: 68  SLLAVYSDHIYRNQPMMIRENKPLISLWAQWYIGLMVPPLMLALLTQEKALDVSPEHFHA 127

		

		Query: 115 AL-DDGMPGALYF--APDALGAPCDAPAPRYAGLRAHLHAVIELLAEIGRVTPRVLWSNA 171

		              + G     +     D    P          +   L  V++ L   G +  +++WSN 

		Sbjct: 128 EFHETGRVACFWVDVCEDKNATPHSPQHRMETLISQALVPVVQALEATGEINGKLIWSNT 187

		

		Query: 172 GNLLDHLFGMYRTL--PCVADPVRDACWLFGASCVDGEPNPLRMPVRDAVPRSALLPTPF 229

		           G L++      + L      + +R A + F  +  +GE NPL    R  V R  LL    

		Sbjct: 188 GYLINWYLTEMKQLLGEATVESLRHALF-FEKTLTNGEDNPL---WRTVVLRDGLL---- 239

		

		Query: 230 RARRVCCLRYEIPGETRLCASCPL 253

		             RR CC RY +P   + C  C L

		Sbjct: 240 -VRRTCCQRYRLPD-VQQCGDCTL 261

		

		

		>FERRIBNDNGPP#Ferrichrome-binding periplasmic protein signature.

		          Length = 296

		

		 Score =  110 bits (275), Expect = 5e-30

		 Identities = 79/303 (26%), Positives = 123/303 (40%), Gaps = 25/303 (8%)

		

		Query: 41  TATALQAGRSLAGNPVVSQASATMPLRAQRVVALDFMFAESAIALDIVPVGMADTAFYPG 100

		           TA AL     L      + A+A  P    R+VAL+++  E  +AL IVP G+ADT  Y  

		Sbjct: 14  TAMALSP---LLWQMNTAHAAAIDP---NRIVALEWLPVELLLALGIVPYGVADTINYRL 67

		

		Query: 101 WLGYASDRLAHVTDVGSRQEPGLEAIAAVQPDLILGVGFRHAPIFDALDRIAPTILFQFS 160

		           W+         V DVG R EP LE +  ++P  ++     + P  + L RIAP   F FS

		Sbjct: 68  WVSEPP-LPDSVIDVGLRTEPNLELLTEMKPSFMVW-SAGYGPSPEMLARIAPGRGFNFS 125

		

		Query: 161 PNVPERGAPRSLPITQLDWMREIFRTIGAVTGRGARAQAVEAQLDAGIARNAARVAAAGR 220

		                       P   L   R+    +  +    + A+   AQ +  I     R     +

		Sbjct: 126 DG--------KQP---LAMARKSLTEMADLLNLQSAAETHLAQYEDFIRSMKPRFV---K 171

		

		Query: 221 GGERIALLQDLGLPDRYWAYTGNSTSAGLARAMGLA-PWPNTPTREGTLYVTSADLLKQR 279

		            G R  LL  L  P     +  NS    +    G+   W       G+  V+   L   +

		Sbjct: 172 RGARPLLLTTLIDPRHMLVFGPNSLFQEILDEYGIPNAWQGETNFWGSTAVSIDRLAAYK 231

		

		Query: 280 DLAVLFVTASGPDVPLAAKLDSPVWRFVPALREHRIALVERNIWGFGGPMSALKLADVMT 339

		           D+ VL          + A + +P+W+ +P +R  R   V   +W +G  +SA+    V+ 

		Sbjct: 232 DVDVLCFDHDNSKD-MDALMATPLWQAMPFVRAGRFQRVP-AVWFYGATLSAMHFVRVLD 289

		

		Query: 340 DTM 342

		           + +

		Sbjct: 290 NAI 292

		

		

		>SUBTILISIN#Subtilisin serine protease family (S8) signature.

		          Length = 326

		

		 Score = 28.3 bits (63), Expect = 0.045

		 Identities = 17/100 (17%), Positives = 32/100 (32%), Gaps = 18/100 (18%)

		

		Query: 7   KPADPRDS------VEGDVAAALDG------APHATPIAERMLHAWRPDDAPAALLAEFV 54

		            P   +D       V G +AA  +       AP A  +  ++L     +   +      +

		Sbjct: 76  DPEIFKDYNGHGTHVAGTIAATENENGVVGVAPEADLLIIKVL-----NKQGSGQYDWII 130

		

		Query: 55  ALFNTDTRHDAATVSVPLG-AADPAAVAAYVARAVREGVI 93

		                        +S+ LG   D   +   V +AV   ++

		Sbjct: 131 QGIYYAIEQKVDIISMSLGGPEDVPELHEAVKKAVASQIL 170

		

		

		>V8PROTEASE#V8 serine protease family signature.

		          Length = 336

		

		 Score = 35.0 bits (80), Expect = 6e-04

		 Identities = 40/260 (15%), Positives = 79/260 (30%), Gaps = 47/260 (18%)

		

		Query: 27  ANSIKTHNDQLR-AFSYETPWLAVGEVG--------GCTATWLGDNGGWTYVLTAAHCAG 77

		           AN I  +ND+ +   +    +  V  +           +   +G +     +LT  H   

		Sbjct: 67  ANVILPNNDRHQITDTTNGHYAPVTYIQVEAPTGTFIASGVVVGKD----TLLTNKHVVD 122

		

		Query: 78  YQGTETAVTKRFTTLDRRVVASGRGTAYVPPQRINKPAGMGGASTDIAILKLPTLHPIAD 137

		                     +             G      ++I K +G G    D+AI+K         

		Sbjct: 123 -ATHGDPHALKAFPSAINQDNYPNGGFTA--EQITKYSGEG----DLAIVKF-------- 167

		

		Query: 138 VLGKPVERPILNDDPHEKDRDVIFVGYGSWGVGAKGSGSYWPANGERRLYGRSRIDSIFE 197

		               P E    N    E  +           V    + + +P +        S+    + 

		Sbjct: 168 ---SPNE---QNKHIGEVVKPATMSNNAETQVNQNITVTGYPGDKPVATMWESKGKITYL 221

		

		Query: 198 LGYGIGASYRSAGPSPFWTRTASGDSGSAWWQIRDGKPVIIATTNGGGDNYSTGARVSKY 257

		            G  +           +   T  G+SGS      +   VI     G  + ++    +++ 

		Sbjct: 222 KGEAMQ----------YDLSTTGGNSGSP--VFNEKNEVIGIHWGGVPNEFNGAVFINEN 269

		

		Query: 258 V-DWIKSVYPEARFLSAEQP 276

		           V +++K    +  F + +QP

		Sbjct: 270 VRNFLKQNIEDIHFANDDQP 289

		

		

		>HTHFIS#FIS bacterial regulatory protein HTH signature.

		          Length = 484

		

		 Score = 38.7 bits (90), Expect = 3e-05

		 Identities = 35/178 (19%), Positives = 56/178 (31%), Gaps = 20/178 (11%)

		

		Query: 7   QRTRAVFPFAALVAQEP-----LQQALLLAAIDPALGGVLVSGPRGTAKSTAARALAELL 61

		           +          LV +        +    L   D     ++++G  GT K   ARAL +  

		Sbjct: 128 KLEDDSQDGMPLVGRSAAMQEIYRVLARLMQTDLT---LMITGESGTGKELVARALHDYG 184

		

		Query: 62  P--EGEFVTLPLSASDEQVTGTLDLAHALAE--NGVRFRPGLLARAHRGVLYVDEVNLLA 117

		               G FV + ++A    +  +    H             G   +A  G L++DE+  + 

		Sbjct: 185 KRRNGPFVAINMAAIPRDLIESELFGHEKGAFTGAQTRSTGRFEQAEGGTLFLDEIGDMP 244

		

		Query: 118 DGLVDTLLDVAASGVNVVERDGVSHAH--DARFVLVGTMNPE----EGELRPQLLDRF 169

		                 LL V   G       G       D R V     + +    +G  R  L  R 

		Sbjct: 245 MDAQTRLLRVLQQG--EYTTVGGRTPIRSDVRIVAATNKDLKQSINQGLFREDLYYRL 300