>RTXTOXIND#Gram-negative bacterial RTX secretion protein D signature. Length = 478 Score = 47.5 bits (113), Expect = 5e-08 Identities = 28/176 (15%), Positives = 55/176 (31%), Gaps = 18/176 (10%) Query: 66 VGGQVTARYVDVGDRVKVGQVLAKLDVADAQLQLNAAKAQLDNAQASA------KTAADE 119 V V G+ V+ G VL KL A+ ++ L A+ + + Sbjct: 103 ENSIVKEIIVKEGESVRKGDVLLKLTALGAEADTLKTQSSLLQARLEQTRYQILSRSIEL 162 Query: 120 LKRFQQLLPINAVSRS--------QFDTVKNQYDAAQAALQQARSNYE-VSANQTGYNQL 170 K + LP ++ +K Q+ Q Q N + A + Sbjct: 163 NKLPELKLPDEPYFQNVSEEEVLRLTSLIKEQFSTWQNQKYQKELNLDKKRAERLTVLAR 222 Query: 171 VSNKNGVITARNIEIG---QVVAAGQAAYQLAIDGEREVVIGVPEQAVSEIKVGQA 223 ++ + + ++ A ++ E + V V E V + ++ Q Sbjct: 223 INRYENLSRVEKSRLDDFSSLLHKQAIAKHAVLEQENKYVEAVNELRVYKSQLEQI 278
>ACRIFLAVINRP#Acriflavin resistance protein family signature. Length = 1034 Score = 477 bits (1230), Expect = e-154 Identities = 228/1066 (21%), Positives = 451/1066 (42%), Gaps = 78/1066 (7%) Query: 5 LSEWALNNKGIVLYFMLLLGIIGAISYSKLSQSEDPPFTFKVMVVQTYWPGATAKEVSTL 64 ++ + + ++L + GA++ +L ++ P + V +PGA A+ V Sbjct: 1 MANFFIRRPIFAWVLAIILMMAGALAILQLPVAQYPTIAPPAVSVSANYPGADAQTVQDT 60 Query: 65 VTDRIEKELMTTGQYDKIMAYS-RPGESLVTFVAKDSLTSDKIPDVWYNVRKKVNDIRHE 123 VT IE+ + + + S G +T + D V+ K+ Sbjct: 61 VTQVIEQNMNGIDNLMYMSSTSDSAGSVTITLTFQSGTDPDIAQV---QVQNKLQLATPL 117 Query: 124 LPNGVQGP-FFNDEFGDTYGNIYVLTGKDFDYAL--LKEYADR-LQLQLQRVKDVSKVEL 179 LP VQ ++ +Y + + + +Y ++ L R+ V V+L Sbjct: 118 LPQEVQQQGISVEKSSSSYLMVAGFVSDNPGTTQDDISDYVASNVKDTLSRLNGVGDVQL 177 Query: 180 IGLQDQKIWIEISNTKAVQLGIPVTAIQDALQKQNSMASAGFFETGTD------RIQIRV 233 G Q + I + + + + + L+ QN +AG I Sbjct: 178 FGAQYA-MRIWLDADLLNKYKLTPVDVINQLKVQNDQIAAGQLGGTPALPGQQLNASIIA 236 Query: 234 SGHLQNIDEIKKMPLLVGD--KTIQLGDVADVYRGFSQPAQPRMRFMGENGIGIALSMRK 291 +N +E K+ L V ++L DVA V G + R G+ G+ + + Sbjct: 237 QTRFKNPEEFGKVTLRVNSDGSVVRLKDVARVELGG-ENYNVIARINGKPAAGLGIKLAT 295 Query: 292 GGDIIALGKNLDTEFAQLQKTLPLGMKLQKVSDQPVAVQRSIHEFIKVLAEAVIIVLLVS 351 G + + K + + A+LQ P GMK+ D VQ SIHE +K L EA+++V LV Sbjct: 296 GANALDTAKAIKAKLAELQPFFPQGMKVLYPYDTTPFVQLSIHEVVKTLFEAIMLVFLVM 355 Query: 352 FFSLG-FRTGLVVAFSIPLVLAMTFAGMNLFDVGLHKISLGALILALGLLVDDAIIAVEM 410 + L R L+ ++P+VL TFA + F ++ +++ ++LA+GLLVDDAI+ VE Sbjct: 356 YLFLQNMRATLIPTIAVPVVLLGTFAILAAFGYSINTLTMFGMVLAIGLLVDDAIVVVEN 415 Query: 411 MA-IKMEQGYSRIKAAGFAWKTTAFPMLTGTLITAAGFLPIATAQSGTGEYTRSIFQVVT 469 + + ME +A + ++ ++ +A F+P+A TG R + Sbjct: 416 VERVMMEDKLPPKEATEKSMSQIQGALVGIAMVLSAVFIPMAFFGGSTGAIYRQFSITIV 475 Query: 470 IALLVSWVAAVLFVPYLGEKLLPDFTKTGHQAP-----WYVRLWARLTKKPQPQTVAISQ 524 A+ +S + A++ P L LL + H+ W+ + Sbjct: 476 SAMALSVLVALILTPALCATLLKPVSAEHHENKGGFFGWFNTTFDHSVN----------- 524 Query: 525 DHHYDPYQSNFYLRFRKMVEFCVTYRKTVIATTVGVFVLSVLMFKIVPQQFFPPSNRAEI 584 H+ + R ++ + + V++F +P F P ++ Sbjct: 525 -HYTNSVGKILGSTGRYLLIY------------ALIVAGMVVLFLRLPSSFLPEEDQGVF 571 Query: 585 LVDLKLEEGASLTATEQAVKKVEKFLSKQKGIDNYVAYVGTGSPRFYLPLDQQLPQASFA 644 L ++L GA+ T++ + +V + K + + + G + Q Q + Sbjct: 572 LTMIQLPAGATQERTQKVLDQVTDYYLKNEKANVESVFTVNG----FSFSGQ--AQNAGM 625 Query: 645 QFVVLASSLDDRDEIRRSLDK---QIRQLLPQVRTRVSLLENGPPV-------GYPLQ-Y 693 FV L ++R+ S + + + L ++R + N P + G+ + Sbjct: 626 AFVSL-KPWEERNGDENSAEAVIHRAKMELGKIRDGFVIPFNMPAIVELGTATGFDFELI 684 Query: 694 RVSGEDQNLVRQEAQKVAKLISENPNT-TNVHLDWGEPSKIISIQIDQDRARQMGVSSVD 752 +G + + Q ++ + +++P + +V + E + +++DQ++A+ +GVS D Sbjct: 685 DQAGLGHDALTQARNQLLGMAAQHPASLVSVRPNGLEDTAQFKLEVDQEKAQALGVSLSD 744 Query: 753 LANFINASITGSAIEQYREKRELIEIRLRGDQSERVEVASLASLAVPTNNGTTVPLAQIA 812 + I+ ++ G+ + + ++ + ++ ++ D R+ + L V + NG VP + Sbjct: 745 INQTISTALGGTYVNDFIDRGRVKKLYVQADAKFRMLPEDVDKLYVRSANGEMVPFSAFT 804 Query: 813 KIEYKFEDGLIWHRNRLPTITVRADIRTQLQPATVVGELAESMDKLRAELPSGYLVEVGG 872 + + + N LP++ ++ + P T G+ M+ L ++LP+G + G Sbjct: 805 TSHWVYGSPRLERYNGLPSMEIQG----EAAPGTSSGDAMALMENLASKLPAGIGYDWTG 860 Query: 873 TVEESARGQNSVNAGMPLFLAVVMTLLMIQLKSLSRATIVLLTAPLGLIGVVLFLLLFNK 932 + N A + + VV L +S S V+L PLG++GV+L LFN+ Sbjct: 861 MSYQERLSGNQAPALVAISFVVVFLCLAALYESWSIPVSVMLVVPLGIVGVLLAATLFNQ 920 Query: 933 PFGFVAMLGTIALSGMIMRNSLILIDQIEQ-DRQAGHPTWEAIIEATVRRFRPIILTALA 991 M+G + G+ +N++++++ + + G EA + A R RPI++T+LA Sbjct: 921 KNDVYFMVGLLTTIGLSAKNAILIVEFAKDLMEKEGKGVVEATLMAVRMRLRPILMTSLA 980 Query: 992 AVLAMIPLSRSIFFG-----PMAVAIMGGLIVATLLTLFFLPALYA 1032 +L ++PL+ S G + + +MGG++ ATLL +FF+P + Sbjct: 981 FILGVLPLAISNGAGSGAQNAVGIGVMGGMVSATLLAIFFVPVFFV 1026 Score = 87.2 bits (216), Expect = 2e-19 Identities = 78/519 (15%), Positives = 183/519 (35%), Gaps = 45/519 (8%) Query: 542 MVEFCVTYRKTVIATTVGVFVLSVLMFKIVPQQFFPPSNRAEILVDLKLEEGASLTATEQ 601 M F + + + + L +P +P + V + T + Sbjct: 1 MANFFIRRPIFAWVLAIILMMAGALAILQLPVAQYPTIAPPAVSVSANYPGADAQTVQDT 60 Query: 602 AVKKVEKFLSKQKGIDN---YVAYVGTGSPRFYLPLDQQLPQASFAQFVVLASSLDDRDE 658 + +E+ ++ + G+ + A + + Sbjct: 61 VTQVIEQNMNGIDNLMYMSSTSDSAGSVTITLTFQSGTDPDIA--------------QVQ 106 Query: 659 IRRSLDKQIRQLLPQVRTRVSLLENGPPVGYPLQYRVSGEDQNLVRQE-----AQKVAKL 713 ++ L LLPQ + + Y + ++ + + A V Sbjct: 107 VQNKLQ-LATPLLPQEVQQQGISVEKSSSSYLMVAGFVSDNPGTTQDDISDYVASNVKDT 165 Query: 714 ISENPNTTNVHLDWGEPSKIISIQIDQDRARQMGVSSVDLANFI---NASITGSAI--EQ 768 +S +V L + + I +D D + ++ VD+ N + N I + Sbjct: 166 LSRLNGVGDVQLFGAQ--YAMRIWLDADLLNKYKLTPVDVINQLKVQNDQIAAGQLGGTP 223 Query: 769 YREKRELIEIRLRGDQSERVEVASLASLAVPTN-NGTTVPLAQIAKIEYKFEDGLIWHR- 826 ++L + Q+ + + N +G+ V L +A++E E+ + R Sbjct: 224 ALPGQQL-NASIIA-QTRFKNPEEFGKVTLRVNSDGSVVRLKDVARVELGGENYNVIARI 281 Query: 827 NRLPTITVRADIRTQLQPATVVGELAESMDKLRAELPSGYLVEVGGTVEESARGQNSVNA 886 N P + + T + + +L+ P G ++V + + Q S++ Sbjct: 282 NGKPAAGLGIKLATGANALDTAKAIKAKLAELQPFFPQG--MKVLYPYDTTPFVQLSIHE 339 Query: 887 GM-PLFLAVVMTLLMIQ--LKSLSRATIVLLTAPLGLIGVVLFLLLFNKPFGFVAMLGTI 943 + LF A+++ L++ L+++ I + P+ L+G L F + M G + Sbjct: 340 VVKTLFEAIMLVFLVMYLFLQNMRATLIPTIAVPVVLLGTFAILAAFGYSINTLTMFGMV 399 Query: 944 ALSGMIMRNSLILIDQIEQDRQAGH-PTWEAIIEATVRRFRPIILTALAAVLAMIPL--- 999 G+++ +++++++ +E+ P EA ++ + ++ A+ IP+ Sbjct: 400 LAIGLLVDDAIVVVENVERVMMEDKLPPKEATEKSMSQIQGALVGIAMVLSAVFIPMAFF 459 Query: 1000 --SRSIFFGPMAVAIMGGLIVATLLTLFFLPALYAAWFK 1036 S + ++ I+ + ++ L+ L PAL A K Sbjct: 460 GGSTGAIYRQFSITIVSAMALSVLVALILTPALCATLLK 498
>IGASERPTASE#IgA-specific serine endopeptidase (S6) signature. Length = 1541 Score = 27.7 bits (61), Expect = 0.011 Identities = 26/107 (24%), Positives = 34/107 (31%), Gaps = 18/107 (16%) Query: 22 EPAIQPGDTLESLSKARITTNVSTQTA--------TPTAQTVATDANTDVKVEDIDPIIG 73 + E +A+ +TQT T QT T V+ E+ + Sbjct: 1057 DATETTAQNREVAKEAKSNVKANTQTNEVAQSGSETKETQTTETKETATVEKEEKAKVET 1116 Query: 74 ETAAEAPKVAVQAEA----------VAAPVIENAPTLAASEPTVSVN 110 E E PKV Q A P EN PT+ EP N Sbjct: 1117 EKTQEVPKVTSQVSPKQEQSETVQPQAEPARENDPTVNIKEPQSQTN 1163
>TCRTETB#Tetracycline resistance protein TetB signature. Length = 458 Score = 46.0 bits (109), Expect = 1e-07 Identities = 38/157 (24%), Positives = 62/157 (39%), Gaps = 2/157 (1%) Query: 32 LPNIANDLGISIPTAGMLITGYALGVMLGAPFMTLWFGGFARRNALIFLMAIFTVGNLIA 91 LP+IAND + + T + L +G + L+F + I G++I Sbjct: 37 LPDIANDFNKPPASTNWVNTAFMLTFSIGTAVYGKLSDQLGIKRLLLFGIIINCFGSVIG 96 Query: 92 AFSPSYMSLL-GARLITSLNHGAFFGIGSVVAASIVPAHKQASAVATMFMGLTIANIGGV 150 S+ SLL AR I AF + VV A +P + A + + + G Sbjct: 97 FVGHSFFSLLIMARFIQGAGAAAFPALVMVVVARYIPKENRGKAFGLIGSIVAMGEGVGP 156 Query: 151 PLATWVGQNIGWRMSFLAISLLGVITMLALWKALPQG 187 + + I W L I ++ +IT+ L K L + Sbjct: 157 AIGGMIAHYIHWSYLLL-IPMITIITVPFLMKLLKKE 192
>TCRTETA#Tetracycline resistance protein signature. Length = 399 Score = 90.3 bits (224), Expect = 8e-22 Identities = 73/380 (19%), Positives = 145/380 (38%), Gaps = 10/380 (2%) Query: 7 RSTFALSSIFALRMLGLFMIIPVFSVVGQSYQYAT--PALIGLAVGVYGLSQAILQIPFS 64 R + S AL +G+ +I+PV + + ++ A G+ + +Y L Q Sbjct: 5 RPLIVILSTVALDAVGIGLIMPVLPGLLRDLVHSNDVTAHYGILLALYALMQFACAPVLG 64 Query: 65 LLADRFSRKPLVVLGLLLFAIGGAIAGLSDTIYGVIIGRAIAG-AGAVSAVVMALLADVT 123 L+DRF R+P++++ L A+ AI + ++ + IGR +AG GA AV A +AD+T Sbjct: 65 ALSDRFGRRPVLLVSLAGAAVDYAIMATAPFLWVLYIGRIVAGITGATGAVAGAYIADIT 124 Query: 124 REEQRTKAMAAMGMSIGLSFVVAFSLGPWLTSLVGISGLFFVTTIMGLIAILMLLLVPKV 183 ++R + M G V LG + + F + GL + L+P+ Sbjct: 125 DGDERARHFGFMSACFGFGMVAGPVLGGLMGGFSPHAPFFAAAALNGLNFLTGCFLLPES 184 Query: 184 TRHHRNYQQGYIAQLKQVIQMGDLNRLHVSVFALHLLLTAMFIYVPSQLIEFAHIPLA-S 242 + R + + + ++ A+ ++ + + + F Sbjct: 185 HKGERRPLRREALNPLASFRWARGMTVVAALMAVFFIMQLVGQVPAALWVIFGEDRFHWD 244 Query: 243 HGLVYLPLLVISLFFAFPSIIVAEKYRKMRGIFLTAITGIIA---GLLLLIFGYQSKYVL 299 + + L + + ++ G + G+IA G +LL F + Sbjct: 245 ATTIGISLAAFGILHSLAQAMITGPVAARLGERRALMLGMIADGTGYILLAFATRGWMAF 304 Query: 300 LAGLGIFFIAFNVMEALLPSWLSKCAPIQSKATAMGVNASSQFLGAFFGGTLGGQLLMLH 359 + + + + L + LS+ + + G A+ L + G L + Sbjct: 305 P--IMVLLASGGIGMPALQAMLSRQVDEERQGQLQGSLAALTSLTSIVGPLLFTAIYAAS 362 Query: 360 -NTAIGWSVLTGIAIIWLLI 378 T GW+ + G A+ L + Sbjct: 363 ITTWNGWAWIAGAALYLLCL 382
>cloacin#Cloacin signature. Length = 551 Score = 29.7 bits (66), Expect = 0.008 Identities = 18/51 (35%), Positives = 23/51 (45%), Gaps = 6/51 (11%) Query: 130 NAPQQGGNGYQNNNNQGGGYGQNNGGGYGGQGGFGNGGNSPQGSGFAPKAP 180 N P GG+G G +G +G G GG G GG+ G+ A AP Sbjct: 43 NNPWGGGSGS------GIHWGGGSGHGNGGGNGNSGGGSGTGGNLSAVAAP 87
>HTHTETR#TetR bacterial regulatory protein HTH signature. Length = 215 Score = 29.6 bits (66), Expect = 0.006 Identities = 9/29 (31%), Positives = 16/29 (55%) Query: 9 AKGLNRERQRAGLSLAEVARRAGVAKSTL 37 A L ++ + SL E+A+ AGV + + Sbjct: 20 ALRLFSQQGVSSTSLGEIAKAAGVTRGAI 48
>HTHTETR#TetR bacterial regulatory protein HTH signature. Length = 215 Score = 43.5 bits (102), Expect = 2e-07 Identities = 31/177 (17%), Positives = 65/177 (36%), Gaps = 10/177 (5%) Query: 1 MEIKSRGRPRSYDPEQVLERALHAFWKGGFSGTSLDTLALATGLNRPSLYAGLGDKRTIY 60 M K++ + + +L+ AL F + G S TSL +A A G+ R ++Y DK ++ Sbjct: 1 MARKTKQEAQE-TRQHILDVALRLFSQQGVSSTSLGEIAKAAGVTRGAIYWHFKDKSDLF 59 Query: 61 IKAMH-YFQKYAQTEFGKALE-HKDTDRSFADVILRYLRTALEVDGYHEDIDLSGCAVIS 118 + + E + D ++++ L + + + I Sbjct: 60 SEIWELSESNIGELELEYQAKFPGDPLSVLREILIHVLESTVTEERRR------LLMEII 113 Query: 119 TAMADALADNE-IQAVLKEVLTEMNEQLYQRLSLAKQNLELPHDTDIDALAFLMTSA 174 + + + +Q + + E +++ Q L + LP D A +M Sbjct: 114 FHKCEFVGEMAVVQQAQRNLCLESYDRIEQTLKHCIEAKMLPADLMTRRAAIIMRGY 170
>BINARYTOXINA#Clostridial binary toxin A signature. Length = 454 Score = 30.4 bits (68), Expect = 0.006 Identities = 27/85 (31%), Positives = 40/85 (47%), Gaps = 14/85 (16%) Query: 57 NNELDANAVRVAAINNISAAKQL-----SYYLYEEFGHDEMFGQDLTKYGYSSDQIVSKN 111 N ELD+ +NNI A +L + +Y G E FG LT Y ++I + + Sbjct: 309 NPELDSK------VNNIENALKLTPIPSNLIVYRRSGPQE-FGLTLTSPEYDFNKIENID 361 Query: 112 AFPETW--KLMGYLNFCVEKFGALP 134 AF E W K++ Y NF G++ Sbjct: 362 AFKEKWEGKVITYPNFISTSIGSVN 386
>HTHTETR#TetR bacterial regulatory protein HTH signature. Length = 215 Score = 46.2 bits (109), Expect = 1e-08 Identities = 24/171 (14%), Positives = 50/171 (29%), Gaps = 11/171 (6%) Query: 5 EASFRALSVLHAAKDLFNQNGFY-IGIDRIIEEAKIPKATFYNYFHSKERLIQMSLTFQI 63 EA +L A LF+Q G + I + A + + Y +F K L Sbjct: 8 EAQETRQHILDVALRLFSQQGVSSTSLGEIAKAAGVTRGAIYWHFKDKSDLFSEIWELSE 67 Query: 64 DALKHEVFSIIHSYRELMAFDKLKKIYL--LHANLDGFYRLPFKAIFEIEKIYPAAYKIV 121 + E+ + L++I + L + + R I + + +V Sbjct: 68 SNI-GELELEYQAKFPGDPLSVLREILIHVLESTVTEERRRLLMEIIFHKCEFVGEMAVV 126 Query: 122 IEYRNWFIKEIHKFL--LTVKATATVE-----DAHMFLFVIDGAMVQLLGT 165 + + E + + ++ G + L+ Sbjct: 127 QQAQRNLCLESYDRIEQTLKHCIEAKMLPADLMTRRAAIIMRGYISGLMEN 177
>PF03544#Gram-negative bacterial tonB protein Length = 243 Score = 29.2 bits (65), Expect = 0.005 Identities = 17/83 (20%), Positives = 21/83 (25%), Gaps = 1/83 (1%) Query: 61 QQVSAAPTNAAPTGAPIPADVPPAPPAGGELAPPAAPTDAVPPAPNQAPPAPQDPNTPPP 120 Q +S A P PP P E P P + AP P P Sbjct: 48 QPISVTMVAPADLEPPQAVQPPPEPVVEPEPEPEPIP-EPPKEAPVVIEKPKPKPKPKPK 106 Query: 121 PADPTQSADPMAKDGGLPADAPM 143 P + K +P Sbjct: 107 PVKKVEQPKRDVKPVESRPASPF 129
>BCTERIALGSPG#Bacterial general secretion pathway protein G signature. Length = 145 Score = 39.1 bits (91), Expect = 1e-06 Identities = 13/34 (38%), Positives = 22/34 (64%) Query: 1 MRGIIPQEGFTLVELMVTIIVMTIIAMMAAPSFT 34 MR Q GFTL+E+MV I+++ ++A + P+ Sbjct: 1 MRATDKQRGFTLLEIMVVIVIIGVLASLVVPNLM 34
>BCTERIALGSPG#Bacterial general secretion pathway protein G signature. Length = 145 Score = 36.0 bits (83), Expect = 5e-05 Identities = 17/51 (33%), Positives = 29/51 (56%), Gaps = 2/51 (3%) Query: 1 MNKIYIQQGFTLVEFMVAIV-LGLLITAAATQLFLTGQISLNTQRAMADLQ 50 M Q+GFTL+E MV IV +G+L + L + + + Q+A++D+ Sbjct: 1 MRATDKQRGFTLLEIMVVIVIIGVLASLVVPNL-MGNKEKADKQKAVSDIV 50
>BCTERIALGSPG#Bacterial general secretion pathway protein G signature. Length = 145 Score = 55.3 bits (133), Expect = 2e-12 Identities = 20/63 (31%), Positives = 35/63 (55%) Query: 1 MKKNMGFTLIELMIVVMIVAVFAAIAIPSYQAQIRRADTAAVQQELLKLAGQLERYKSQN 60 K GFTL+E+M+V++I+ V A++ +P+ +AD +++ L L+ YK N Sbjct: 4 TDKQRGFTLLEIMVVIVIIGVLASLVVPNLMGNKEKADKQKAVSDIVALENALDMYKLDN 63 Query: 61 FSY 63 Y Sbjct: 64 HHY 66
>BCTERIALGSPG#Bacterial general secretion pathway protein G signature. Length = 145 Score = 46.0 bits (109), Expect = 3e-09 Identities = 19/66 (28%), Positives = 38/66 (57%) Query: 1 MLKNGSHQGFTLIELMIVVAIIAILAAIAYPSYTQYKIRTNRTDLQAEMLRINQRLQSYK 60 M +GFTL+E+M+V+ II +LA++ P+ K + ++ ++++ + L YK Sbjct: 1 MRATDKQRGFTLLEIMVVIVIIGVLASLVVPNLMGNKEKADKQKAVSDIVALENALDMYK 60 Query: 61 VVNHSF 66 + NH + Sbjct: 61 LDNHHY 66
>ISCHRISMTASE#Isochorismatase signature. Length = 312 Score = 27.7 bits (61), Expect = 0.043 Identities = 10/38 (26%), Positives = 19/38 (50%) Query: 64 AEPLAKAIAHAKQLASQAGHAHVPVVYMSPQGKTLNEQ 101 A P+ + A+ ++L +Q +PVVY + G + Sbjct: 50 ASPVTELSANIRKLKNQCVQLGIPVVYTAQPGSQNPDD 87
>ADHESNFAMILY#Adhesin family signature. Length = 309 Score = 28.3 bits (63), Expect = 0.044 Identities = 17/82 (20%), Positives = 34/82 (41%), Gaps = 9/82 (10%) Query: 25 YWLSPDSKNTSAQVSENTAQNLASAQPTDHSSL---NEDAYHSK-SQQDTEVNCQLKTDS 80 WL+ +N +N A+ L++ P ++ N Y K + D E + Sbjct: 140 AWLNL--ENGIIFA-KNIAKQLSAKDP-NNKEFYEKNLKEYTDKLDKLDKESKDKFNKIP 195 Query: 81 SQHLVVNSQTRDCFEYFITQYG 102 ++ ++ + + F+YF YG Sbjct: 196 AEKKLIVT-SEGAFKYFSKAYG 216
>SUBTILISIN#Subtilisin serine protease family (S8) signature. Length = 326 Score = 126 bits (319), Expect = 4e-35 Identities = 74/334 (22%), Positives = 121/334 (36%), Gaps = 69/334 (20%) Query: 120 VSLLNDPNVKAVYPNRINQTTTNESLPLINQPQANTNGFTGEGSSVAVIDTGVNYLHSDF 179 V ++ +K + +I P G G VAV+DTG + H D Sbjct: 5 VHIIPYQVIKQEQ----QVNEIPRGVEMIQAPAVWNQT-RGRGVKVAVLDTGCDADHPDL 59 Query: 180 GCTAVNTPSNTCRVVYSFDSAPDDGALDDDGHGSNVSGIVSK---------VATKTKIIG 230 + R D + D +GHG++V+G ++ VA + ++ Sbjct: 60 KARII-----GGRNFTDDDEGDPEIFKDYNGHGTHVAGTIAATENENGVVGVAPEADLLI 114 Query: 231 IDVFRKVRSQGKWVSTAYDSDILAGINWAVNNAQTYNIKAVNLSLGVPGVKYTSECSDSS 290 I V K + I+ GI +A+ + +++SLG P Sbjct: 115 IKVLNKQ-------GSGQYDWIIQGIYYAIEQ----KVDIISMSLGGPE-------DVPE 156 Query: 291 YGTAFANARAAGVVPVVASGNDAFSDG----ISSPACVAGAVRVGAVYDSNIGGVSWGNP 346 A A A+ ++ + A+GN+ D + P C + VGA Sbjct: 157 LHEAVKKAVASQILVMCAAGNEGDGDDRTDELGYPGCYNEVISVGA-------------- 202 Query: 347 VKCSDPTTAADKVACFSNGGSLVTLLAPGAMITAGGY-----TMGGTSQATPHVAGAIAL 401 + FSN + V L+APG I + T GTS ATPHVAGA+AL Sbjct: 203 ------INFDRHASEFSNSNNEVDLVAPGEDILSTVPGGKYATFSGTSMATPHVAGALAL 256 Query: 402 LRA---NSVSPTESIDQTISRLKTTGKPITDSRT 432 ++ S + + ++L P+ +S Sbjct: 257 IKQLANASFERDLTEPELYAQLIKRTIPLGNSPK 290
>TYPE4SSCAGA#Type IV secretion system CagA exotoxin signature. Length = 1147 Score = 27.0 bits (59), Expect = 0.022 Identities = 25/81 (30%), Positives = 34/81 (41%), Gaps = 11/81 (13%) Query: 38 LWFLPSNQVKVSLETPEILANYTFNKHVINHHFCKNCGIHPYAQGIDPQGNS-------- 89 LW + +V SL L NY N H+ + KN I+ A G+ Q N Sbjct: 1004 LWVESAKKVPASLSAK--LDNYATNSHIRINSNIKNGAINEKATGMLTQKNPEWLKLVND 1061 Query: 90 -ILAINVRCIDDIDLDKIKIN 109 I+A NV + + DKI N Sbjct: 1062 KIVAHNVGSVPLSEYDKIGFN 1082
>RTXTOXINA#Gram-negative bacterial RTX toxin determinant A family signature. Length = 1024 Score = 28.8 bits (64), Expect = 0.015 Identities = 27/115 (23%), Positives = 46/115 (40%), Gaps = 16/115 (13%) Query: 63 DVVSYDQQKDEYLFVDCSPESPKG----RRSLCYDREALEARKDHPPKNSAIDVAKEMGA 118 DVV YD+ YL +D + + G R L D + L+ K + V K Sbjct: 639 DVVYYDKTDTGYLTIDGTKATEAGNYTVTRVLGGDVKVLQ----EVVKEQEVSVGKR--- 691 Query: 119 ELLTEEQYHELQKLGEFDFKTSSWLKTPDEIRRLDGAIFADRRYGRVF--IYHNG 171 T+ + +E + + + L + +E+ G AD+ +G F I+H Sbjct: 692 TEKTQYRSYEFTHINGKNLTETDNLYSVEELI---GTTRADKFFGSKFTDIFHGA 743
>HTHTETR#TetR bacterial regulatory protein HTH signature. Length = 215 Score = 67.0 bits (163), Expect = 6e-16 Identities = 27/135 (20%), Positives = 52/135 (38%), Gaps = 7/135 (5%) Query: 20 RGRLLRGAAYLFHKQGYDKTTVRELAQFIGIQSGSLFHHFKSKDDILAHVMEETIIYNLA 79 R +L A LF +QG T++ E+A+ G+ G+++ HFK K D+ + + E + Sbjct: 13 RQHILDVALRLFSQQGVSSTSLGEIAKAAGVTRGAIYWHFKDKSDLFSEIWELSESNIGE 72 Query: 80 RLQDAAAQ-STDPEQQLRALIKA---ELISITGDTGAAMAVLVYEWFALSKEKQDDLLKM 135 + A+ DP LR ++ ++ + F + + Sbjct: 73 LELEYQAKFPGDPLSVLREILIHVLESTVTEERRRLLMEIIFHKCEFVGEMAV---VQQA 129 Query: 136 RNEYEQIWLDVIEKL 150 + D IE+ Sbjct: 130 QRNLCLESYDRIEQT 144
>DHBDHDRGNASE#2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase signature. Length = 261 Score = 106 bits (266), Expect = 2e-29 Identities = 64/257 (24%), Positives = 111/257 (43%), Gaps = 17/257 (6%) Query: 20 KVIIVTGGGSGIGRCTAHELAALGAQVVITGRKIEKLEKVSQEIIEDGGRVHFIVCDNRE 79 K+ +TG GIG A LA+ GA + EKLEKV + + D R+ Sbjct: 9 KIAFITGAAQGIGEAVARTLASQGAHIAAVDYNPEKLEKVVSSLKAEARHAEAFPADVRD 68 Query: 80 EEQVKNMIAEVIEKFGKLDGLVNNAGGQFPSALENISANGFDAVVRNNLHATFYLMREAY 139 + + A + + G +D LVN AG P + ++S ++A N F R Sbjct: 69 SAAIDEITARIEREMGPIDILVNVAGVLRPGLIHSLSDEEWEATFSVNSTGVFNASRSVS 128 Query: 140 NQWMAKHGGSIVNMTADMWGGMP--GMGHSGAARSGVDNLTKTASVEWGKSGVRVNAVAP 197 M + GSIV + ++ G+P M ++++ TK +E + +R N V+P Sbjct: 129 KYMMDRRSGSIVTVGSNP-AGVPRTSMAAYASSKAAAVMFTKCLGLELAEYNIRCNIVSP 187 Query: 198 G----------WIVSSGMDNYSGDFAKVIIPSLAGNVPLKRMGTESEVSSAICYLLSDAA 247 G W +G + + + +PLK++ S+++ A+ +L+S A Sbjct: 188 GSTETDMQWSLWADENGAEQVIKGSLE----TFKTGIPLKKLAKPSDIADAVLFLVSGQA 243 Query: 248 AFVSGVTLRIDGAASQG 264 ++ L +DG A+ G Sbjct: 244 GHITMHNLCVDGGATLG 260
>RTXTOXIND#Gram-negative bacterial RTX secretion protein D signature. Length = 478 Score = 32.5 bits (74), Expect = 0.005 Identities = 20/90 (22%), Positives = 37/90 (41%), Gaps = 7/90 (7%) Query: 559 AIRNVTYAAPEIADVAGDGN---IRAPMDGAVVNILVNKGDQVVKGQTLLVLEAMKIQQQ 615 + V A + G I+ + V I+V +G+ V KG LL L A+ Sbjct: 76 VLGQVEIVATANGKLTHSGRSKEIKPIENSIVKEIIVKEGESVRKGDVLLKLTAL----G 131 Query: 616 IKSDVDGVVDDVLGQQGQQVKKRQMLFSIQ 645 ++D +L + +Q + + + SI+ Sbjct: 132 AEADTLKTQSSLLQARLEQTRYQILSRSIE 161 Score = 29.8 bits (67), Expect = 0.038 Identities = 14/64 (21%), Positives = 29/64 (45%), Gaps = 12/64 (18%) Query: 579 IRAPMDGAVVNILVNKGDQVVK-GQTLLVL----EAMKIQQQIKS-DVDGVVDDVLGQQG 632 IRAP+ V + V+ VV +TL+V+ + +++ +++ D+ + G Sbjct: 330 IRAPVSVKVQQLKVHTEGGVVTTAETLMVIVPEDDTLEVTALVQNKDIGFI------NVG 383 Query: 633 QQVK 636 Q Sbjct: 384 QNAI 387
>OMPADOMAIN#OMPA domain signature. Length = 346 Score = 96.5 bits (240), Expect = 1e-26 Identities = 43/121 (35%), Positives = 63/121 (52%), Gaps = 11/121 (9%) Query: 48 TLGLPERLLFDFNNAELKQSHEAELVRLANQLNKYDLN--KLKIVGHTDDVGDAAYNQKL 105 L +LF+FN A LK +A L +L +QL+ D + ++G+TD +G AYNQ L Sbjct: 214 HFTLKSDVLFNFNKATLKPEGQAALDQLYSQLSNLDPKDGSVVVLGYTDRIGSDAYNQGL 273 Query: 106 SEERAQSVANLFLARGFKKENIYVIGRGSTQPYVPNTTNENR---------AINRRVAIV 156 SE RAQSV + +++G + I G G + P NT + + A +RRV I Sbjct: 274 SERRAQSVVDYLISKGIPADKISARGMGESNPVTGNTCDNVKQRAALIDCLAPDRRVEIE 333 Query: 157 V 157 V Sbjct: 334 V 334
>RTXTOXIND#Gram-negative bacterial RTX secretion protein D signature. Length = 478 Score = 52.1 bits (125), Expect = 2e-09 Identities = 38/220 (17%), Positives = 74/220 (33%), Gaps = 49/220 (22%) Query: 102 RLNNQDNVARLAQARANLASAQSQAELARNLMNRKQRLFNQGFIARVEF---EQSQVDYK 158 LN A A + ++ + + ++ ++ L ++ IA+ E V+ Sbjct: 206 ELNLDKKRAERLTVLARINRYENLSRVEKSRLDDFSSLLHKQAIAKHAVLEQENKYVEAV 265 Query: 159 GQLESVKAQ-------------------------------QANVDIA------RKADQDG 181 +L K+Q Q +I K ++ Sbjct: 266 NELRVYKSQLEQIESEILSAKEEYQLVTQLFKNEILDKLRQTTDNIGLLTLELAKNEERQ 325 Query: 182 ---IITSPISGVITKRQV-EPGQTVSVGQTLFEIV-NPDQLEIQAKLPIEQQSALKVGSS 236 +I +P+S + + +V G V+ +TL IV D LE+ A + + + VG + Sbjct: 326 QASVIRAPVSVKVQQLKVHTEGGVVTTAETLMVIVPEDDTLEVTALVQNKDIGFINVGQN 385 Query: 237 IQYQI----QGNSKQLNATLTRISPVADQDSRQIEFFAVP 272 ++ L + I+ A +D R F V Sbjct: 386 AIIKVEAFPYTRYGYLVGKVKNINLDAIEDQRLGLVFNVI 425 Score = 38.3 bits (89), Expect = 5e-05 Identities = 22/116 (18%), Positives = 44/116 (37%), Gaps = 10/116 (8%) Query: 55 GALDSQTAFTGTIRAVQQS-SIQAQVSATATTVTTNVGQQVQKGQVLVRLNNQDNVARLA 113 G ++ G + +S I+ ++ + G+ V+KG VL++L Sbjct: 78 GQVEIVATANGKLTHSGRSKEIKPIENSIVKEIIVKEGESVRKGDVLLKLTA-------L 130 Query: 114 QARANLASAQSQAELARNLMNRKQRLFNQGFIARVEFEQSQVDYKGQLESVKAQQA 169 A A+ QS AR R Q L I + + ++ + ++V ++ Sbjct: 131 GAEADTLKTQSSLLQARLEQTRYQILSRS--IELNKLPELKLPDEPYFQNVSEEEV 184
>HTHFIS#FIS bacterial regulatory protein HTH signature. Length = 484 Score = 78.7 bits (194), Expect = 2e-20 Identities = 31/118 (26%), Positives = 55/118 (46%), Gaps = 2/118 (1%) Query: 9 KVMVIDDSKTIRRTAETLLQREGCEVITAVDGFEALSKIAEANPDIVFVDIMMPRLDGYQ 68 ++V DD IR L R G +V + IA + D+V D++MP + + Sbjct: 5 TILVADDDAAIRTVLNQALSRAGYDVRITSNAATLWRWIAAGDGDLVVTDVVMPDENAFD 64 Query: 69 TCALIKNSQNYQNIPVIMLSSKDGLFDQAKGRVVGSDEYLTKPFSKDELLNAIRNHVS 126 IK + ++PV+++S+++ K G+ +YL KPF EL+ I ++ Sbjct: 65 LLPRIKKA--RPDLPVLVMSAQNTFMTAIKASEKGAYDYLPKPFDLTELIGIIGRALA 120
>HTHFIS#FIS bacterial regulatory protein HTH signature. Length = 484 Score = 82.2 bits (203), Expect = 1e-21 Identities = 39/118 (33%), Positives = 58/118 (49%), Gaps = 2/118 (1%) Query: 2 ARILIVDDSPTETYRFREILTKHGYDVLEASNGADGVTLAKAEQPDLVLMDVVMPGVNGF 61 A IL+ DD + L++ GYDV SN A A DLV+ DVVMP N F Sbjct: 4 ATILVADDDAAIRTVLNQALSRAGYDVRITSNAATLWRWIAAGDGDLVVTDVVMPDENAF 63 Query: 62 QATRQITRDEDTKHIPVVIVSTKDQATDRVWGKRQGAIDYLIKPIEEKQLIDVIKQFL 119 +I + +PV+++S ++ + +GA DYL KP + +LI +I + L Sbjct: 64 DLLPRI-KKAR-PDLPVLVMSAQNTFMTAIKASEKGAYDYLPKPFDLTELIGIIGRAL 119
>FLAGELLIN#Flagellin signature. Length = 507 Score = 31.2 bits (70), Expect = 0.014 Identities = 22/228 (9%), Positives = 63/228 (27%), Gaps = 10/228 (4%) Query: 452 STAMNEMAQSIDQVSSNASESTEVAERSVQIASNGAQVVNRSIEGMDTIREQIQETSKRI 511 + + + Q S NA++ +A Q +N +++ + + Q + Sbjct: 50 ANRFTSNIKGLTQASRNANDGISIA----QTTEGALNEINNNLQRVRELSVQATNGTNSD 105 Query: 512 KRLGESSQEIGNIVSLINDIADQT-----NILALNAAIQASMAGEAGRGFAVVADEVQRL 566 L EI + I+ +++QT +L+ + ++ + G + ++ Sbjct: 106 SDLKSIQDEIQQRLEEIDRVSNQTQFNGVKVLSQDNQMKIQVGANDGETITIDLQKIDVK 165 Query: 567 AERSASATKQIETLV-KTIQTDTNEAVISMEQTTTEVVRGANLAKDAGIALDEIQKVSGD 625 + + + V + + + D D Sbjct: 166 SLGLDGFNVNGPKEATVGDLKSSFKNVTGYDTYAVGANKYRVDVNSGAVVTDTTAPTVPD 225 Query: 626 LANLMASISDAAKLQSASASHIATTMTVVQEITSQTTTATFDTARSVS 673 + A+ + + + + T + A + Sbjct: 226 KVYVNAANGQLTTDDAENNTAVDLFKTTKSTAGTAEAKAIAGAIKGGK 273
>PF07132#Harpin protein (HrpN) Length = 356 Score = 27.0 bits (59), Expect = 0.015 Identities = 24/72 (33%), Positives = 42/72 (58%), Gaps = 3/72 (4%) Query: 13 TLVGVGVGVGVGVGVGVGVGVGVGVGVGVGVGVGVGVGVGVGVGVGVGVGVGVGVGVGVG 72 T++ +G +G G+G G+G G+G +G G +G G+G G+G +G G+G +G G+G Sbjct: 57 TMMFMGSMMGGGLGGGLG---GLGSSLGGLGGGLLGGGLGGGLGSSLGSGLGSALGGGLG 113 Query: 73 VGVGVESLSSDP 84 +G + +P Sbjct: 114 GALGAGMNAMNP 125
>TCRTETOQM#Tetracycline resistance protein TetO/TetQ/TetM family signature. Length = 639 Score = 30.2 bits (68), Expect = 0.017 Identities = 7/26 (26%), Positives = 11/26 (42%) Query: 179 YKYTVGQPFIYPRNDLNYAENFLHMM 204 Y T G+P PR + + +M Sbjct: 610 YHVTTGEPVCQPRRPNSRIDKVRYMF 635
>IGASERPTASE#IgA-specific serine endopeptidase (S6) signature. Length = 1541 Score = 30.4 bits (68), Expect = 0.035 Identities = 44/193 (22%), Positives = 70/193 (36%), Gaps = 19/193 (9%) Query: 145 NNVILENGVTTGQGGAI---YAGADIAFQNSQILSSQATNGGAIYLASPNITLSASHSLL 201 N + G TG + Y G + LS +A N N+ L+ S + + Sbjct: 771 NKAQVHIGYKTGDTVCVRSDYTGYVTCTTDK--LSDKALNSFNPTNLRGNVNLTESANFV 828 Query: 202 KGNNATQGSVLSMGCFSDTVYAPRTITLTSNSIVNNGNTASTSTFEFCGKPSA------T 255 G G++ S G + LT NS V+ + A+ S T Sbjct: 829 LGKANLFGTIQSRGNSQVRLTENSHWHLTGNSDVHQLDLANGHIHLNSADNSNNVTKYNT 888 Query: 256 LSVNTIAKNIANSTNGSIIKFTGDTNNPANTSSILSSSSSLVLLN--NTIVENNANSTFL 313 L+VN++ S NGS T +N + + S++ L + E N N L Sbjct: 889 LTVNSL------SGNGSFYYLTDLSNKQGDKVVVTKSATGNFTLQVADKTGEPNHNELTL 942 Query: 314 YDKLGAKKLSFNV 326 +D A++ NV Sbjct: 943 FDASKAQRDHLNV 955
>OMPADOMAIN#OMPA domain signature. Length = 346 Score = 109 bits (274), Expect = 4e-31 Identities = 32/117 (27%), Positives = 53/117 (45%), Gaps = 11/117 (9%) Query: 76 VHFDYDSSDLSTEDYQTLQAHAQFL--MANANSKVALTGHTDERGTREYNMALGERRAKA 133 V F+++ + L E L L + + V + G+TD G+ YN L ERRA++ Sbjct: 221 VLFNFNKATLKPEGQAALDQLYSQLSNLDPKDGSVVVLGYTDRIGSDAYNQGLSERRAQS 280 Query: 134 VQSYLITNGVNPQQLEAVSYGKEAPVNAGHDESA---------WKENRRVEINYEAV 181 V YLI+ G+ ++ A G+ PV ++ +RRVEI + + Sbjct: 281 VVDYLISKGIPADKISARGMGESNPVTGNTCDNVKQRAALIDCLAPDRRVEIEVKGI 337
>ANTHRAXTOXNA#Anthrax toxin LF subunit signature. Length = 800 Score = 29.3 bits (65), Expect = 0.035 Identities = 17/110 (15%), Positives = 42/110 (38%), Gaps = 11/110 (10%) Query: 173 AERYTLQIADTDGEQPKTVLSSRDPILSPAWTPDAKKIAYVSFETKRPAIYLQDLSTGTR 232 A R+ + + E PK +++ +D + ++++ V +E + D+ + + Sbjct: 138 ASRF---VFEKKRETPKLIINIKD------YAINSEQSKEVYYEIGK--GISLDIISKDK 186 Query: 233 EVLTSFKGLNGAPSFSPDGQSMLFTASMNGNPEIYQMDLSTRQVKRMTND 282 + F L + S D +LF+ E+ + +K + Sbjct: 187 SLDPEFLNLIKSLSDDSDSSDLLFSQKFKEKLELNNKSIDINFIKENLTE 236
>IGASERPTASE#IgA-specific serine endopeptidase (S6) signature. Length = 1541 Score = 60.8 bits (147), Expect = 7e-12 Identities = 59/392 (15%), Positives = 126/392 (32%), Gaps = 43/392 (10%) Query: 49 LVKPEDLPPPLAKEVEQETTATN-EAKEVLTPIVDETLPENLPATPPPPTAQQLAAQKQK 107 V ++ P + + + +N E + P+ A+ + + Sbjct: 991 TVDTTNITTPNNIQADVPSVPSNNEEIARVDEAPVPPPAPATPSETTETVAENSKQESKT 1050 Query: 108 VEQAQQ---AKLAEQKRKAEEAAKAKQATEQQRVEEAQKQQAEAKRQTEAKARAEAEQKR 164 VE+ +Q A+ + A+EA K +A QT A++ +E K Sbjct: 1051 VEKNEQDATETTAQNREVAKEA----------------KSNVKANTQTNEVAQSGSETKE 1094 Query: 165 KAEQSAKAEADAKARQKVAEEAKRKAETDAKLKREAQKSENAKLLAQQEAKRKAEAEAKA 224 K A V +E K K ET+ + E K+ +Q K++ + Sbjct: 1095 TQTTETKETAT------VEKEEKAKVETE-------KTQEVPKVTSQVSPKQEQSETVQP 1141 Query: 225 KQQKANDDAKRKADADAKAKQQKANDDAKRKADADAKAKQQKANDDAKRKADADAKAKQQ 284 + + A ++ + +++ D + + + +Q ++ + + Sbjct: 1142 QAEPARENDPTVNIKEPQSQTNTTADTEQPAKETSSNVEQPVTESTTVNTGNSVVENPEN 1201 Query: 285 KAADDAKRKADADAKAKQQKANEDAKRKADADAKAKQQKANDDAKRKADADAKAKQQKAN 344 + ++++ K + + + R + + +ND R A N Sbjct: 1202 TTPATTQPTVNSESSNKPKNRHRRSVRSVPHNVEPATTSSND---RSTVALCDLTSTNTN 1258 Query: 345 DDAKRKADADAKAKQQKAADDAKRKAEAEAEAKAASAQKAQEEAAQKKAEAKKVASSARR 404 +DA+AK Q A + + + + + K +SS R Sbjct: 1259 -----AVLSDARAKAQFVALNVGKAVSQHISQLEMNNEGQYNVWVSNTSMNKNYSSSQYR 1313 Query: 405 DFEQK--IRRSWDVPTGSSGKTVGVRFTLSDS 434 F K + T S+ +G FT + Sbjct: 1314 RFSSKSTQTQLGWDQTISNNVQLGGVFTYVRN 1345 Score = 37.0 bits (85), Expect = 2e-04 Identities = 20/188 (10%), Positives = 56/188 (29%) Query: 277 ADAKAKQQKAADDAKRKADADAKAKQQKANEDAKRKADADAKAKQQKANDDAKRKADADA 336 + +A + + A D A + A+ +Q++ K + DA Sbjct: 1001 NNIQADVPSVPSNNEEIARVDEAPVPPPAPATPSETTETVAENSKQESKTVEKNEQDATE 1060 Query: 337 KAKQQKANDDAKRKADADAKAKQQKAADDAKRKAEAEAEAKAASAQKAQEEAAQKKAEAK 396 Q + + + A ++ K E K + + +E+A + + + Sbjct: 1061 TTAQNREVAKEAKSNVKANTQTNEVAQSGSETKETQTTETKETATVEKEEKAKVETEKTQ 1120 Query: 397 KVASSARRDFEQKIRRSWDVPTGSSGKTVGVRFTLSDSGSVNSIVITRSSGDDALDASIK 456 +V + ++ + P + + + S + ++++ Sbjct: 1121 EVPKVTSQVSPKQEQSETVQPQAEPARENDPTVNIKEPQSQTNTTADTEQPAKETSSNVE 1180 Query: 457 AAIQASAP 464 + S Sbjct: 1181 QPVTESTT 1188
>TCRTETB#Tetracycline resistance protein TetB signature. Length = 458 Score = 65.3 bits (159), Expect = 1e-13 Identities = 43/146 (29%), Positives = 71/146 (48%), Gaps = 5/146 (3%) Query: 42 KNNNQSQWVIIGIFSGMTIGQLIAGPLSDAIGRKRILFTGIIIYFLGSLLCFTTQS-FEW 100 K + WV +IG + G LSD +G KR+L GIII GS++ F S F Sbjct: 46 KPPASTNWVNTAFMLTFSIGTAVYGKLSDQLGIKRLLLFGIIINCFGSVIGFVGHSFFSL 105 Query: 101 FLVGRFIQGIGVSGPYVATISIVRDKY-SGAQMARIMSLIMMVFMVAPAVAPSLGQLIIH 159 ++ RFIQG G + + A + +V +Y + LI + + V P++G +I H Sbjct: 106 LIMARFIQGAG-AAAFPALVMVVVARYIPKENRGKAFGLIGSIVAMGEGVGPAIGGMIAH 164 Query: 160 FFGWREIFVLYMVYATVIGAWIALRL 185 + W + ++ M+ T+I ++L Sbjct: 165 YIHWSYLLLIPMI--TIITVPFLMKL 188
>PF06580#Sensor histidine kinase Length = 349 Score = 31.8 bits (72), Expect = 0.008 Identities = 19/95 (20%), Positives = 39/95 (41%), Gaps = 3/95 (3%) Query: 21 IFGFSEFLAGLALMILAWTIADVRYRFRVEVAPLPLKIITFSVVIFVGLSTILTDLWRAS 80 IF + L GL L + + ++ + + L+++ VVI + T +WR Sbjct: 43 IFNIAISLMGLVLTHAYRSFIKRQGWLKLNMGQIILRVLPACVVIGMVWFVANTSIWRLL 102 Query: 81 AWLVLSQTFITSALWQAFLAITFFITFLIWIWFAF 115 A++ T + L+I F + + ++W Sbjct: 103 AFI---NTKPVAFTLPLALSIIFNVVVVTFMWSLL 134
>SURFACELAYER#Lactobacillus surface layer protein signature. Length = 439 Score = 31.9 bits (72), Expect = 0.004 Identities = 25/124 (20%), Positives = 44/124 (35%), Gaps = 9/124 (7%) Query: 255 VFPGNQGGPLMHAIAAKAICFKEAMSDEFKAYQQQVVKNAQAMAEVLIARGYDVVSGG-- 312 + NQG + ++ A A + K A+ + L A+ +V S G Sbjct: 212 IDADNQGQLNITSVVAAINSKYFAAQYDKKQLTNVTFDTETAVKDALKAQKIEVSSVGYF 271 Query: 313 TENHLFLLSL-IKQDVTGKEADAWLGAAHITVNKNSVPNDPRSPFVTS------GIRIGT 365 H F +++ + GK A + V VP+ ++ + R+GT Sbjct: 272 KAPHTFTVNVKATSNKNGKSATLPVTVTVPNVADPVVPSQSKTIMHNAYFYDKDAKRVGT 331 Query: 366 PAVT 369 VT Sbjct: 332 DKVT 335
>ACRIFLAVINRP#Acriflavin resistance protein family signature. Length = 1034 Score = 1099 bits (2845), Expect = 0.0 Identities = 427/1042 (40%), Positives = 651/1042 (62%), Gaps = 18/1042 (1%) Query: 3 ISKFFIDRPIFAGVLSVLILLAGLLSVFKLPISEYPEVVPPSVVVRAQYPGANPKVIAET 62 ++ FFI RPIFA VL++++++AG L++ +LP+++YP + PP+V V A YPGA+ + + +T Sbjct: 1 MANFFIRRPIFAWVLAIILMMAGALAILQLPVAQYPTIAPPAVSVSANYPGADAQTVQDT 60 Query: 63 VASPLEESINGVEDMLYMQSQANSDGNLTITVNFKLGIDPDKAQQLVQNRVSQAMPRLPE 122 V +E+++NG+++++YM S ++S G++TIT+ F+ G DPD AQ VQN++ A P LP+ Sbjct: 61 VTQVIEQNMNGIDNLMYMSSTSDSAGSVTITLTFQSGTDPDIAQVQVQNKLQLATPLLPQ 120 Query: 123 DVQRLGVTTLKSSPTLTMVVHLTSPDNRYDMTYLRNYAVLNVKDRLARLQGVGEVGLFGS 182 +VQ+ G++ KSS + MV S + + +Y NVKD L+RL GVG+V LFG Sbjct: 121 EVQQQGISVEKSSSSYLMVAGFVSDNPGTTQDDISDYVASNVKDTLSRLNGVGDVQLFG- 179 Query: 183 GDYAMRVWLDPQKVAQRNLTATEIVSAIREQNIQVAAGTIGASPTNS--PVQLSVNAQGR 240 YAMR+WLD + + LT ++++ ++ QN Q+AAG +G +P + S+ AQ R Sbjct: 180 AQYAMRIWLDADLLNKYKLTPVDVINQLKVQNDQIAAGQLGGTPALPGQQLNASIIAQTR 239 Query: 241 LTTEQEFSDIILKTAPDGAVTRLGDVARVELAASQYGLRSLLDNKQAVAIPIFQAPGANA 300 +EF + L+ DG+V RL DVARVEL Y + + ++ K A + I A GANA Sbjct: 240 FKNPEEFGKVTLRVNSDGSVVRLKDVARVELGGENYNVIARINGKPAAGLGIKLATGANA 299 Query: 301 LQVSDQVRSTMKELSKDFPSSIKYDIVYDPTQFVRASIKAVVHTLLEAIALVVVVVILFL 360 L + +++ + EL FP +K YD T FV+ SI VV TL EAI LV +V+ LFL Sbjct: 300 LDTAKAIKAKLAELQPFFPQGMKVLYPYDTTPFVQLSIHEVVKTLFEAIMLVFLVMYLFL 359 Query: 361 QTWRASIIPLLAVPVSIIGTFALMLAFGYSINALSLFGMVLAIGIVVDDAIVVVENVER- 419 Q RA++IP +AVPV ++GTFA++ AFGYSIN L++FGMVLAIG++VDDAIVVVENVER Sbjct: 360 QNMRATLIPTIAVPVVLLGTFAILAAFGYSINTLTMFGMVLAIGLLVDDAIVVVENVERV 419 Query: 420 NIEAGLSPRDATYRAMREVSGPIIAIALTLVAVFVPLAFMTGLTGQFYKQFAMTIAISTV 479 +E L P++AT ++M ++ G ++ IA+ L AVF+P+AF G TG Y+QF++TI + Sbjct: 420 MMEDKLPPKEATEKSMSQIQGALVGIAMVLSAVFIPMAFFGGSTGAIYRQFSITIVSAMA 479 Query: 480 ISAFNSLTLSPALAAMLLKGHDAKPDALTRLMNRVFGRFFALFNRVFTRASDNYGKGVSR 539 +S +L L+PAL A LLK ++ + G FF FN F + ++Y V + Sbjct: 480 LSVLVALILTPALCATLLKP-------VSAEHHENKGGFFGWFNTTFDHSVNHYTNSVGK 532 Query: 540 VISHKASAMGVYAALLGLTVGISYIVPGGFVPAQDKQYLISFAQLPNGASLDRTEAVIRK 599 ++ + +YA ++ V + +P F+P +D+ ++ QLP GA+ +RT+ V+ + Sbjct: 533 ILGSTGRYLLIYALIVAGMVVLFLRLPSSFLPEEDQGVFLTMIQLPAGATQERTQKVLDQ 592 Query: 600 MSDTALK--QPGVESAVAFPGLSINGFTNSSSAGIVFVTLKPFDERKAKDLSANAIAGAL 657 ++D LK + VES G S +G + +AG+ FV+LKP++ER + SA A+ Sbjct: 593 VTDYYLKNEKANVESVFTVNGFSFSG--QAQNAGMAFVSLKPWEERNGDENSAEAVIHRA 650 Query: 658 NQKYSAIQDAYIAVFPPPPVMGLGTMGGFKLQLEDRGALGYSALNDAAQNFM-KAAQSAP 716 + I+D ++ F P ++ LGT GF +L D+ LG+ AL A + AAQ Sbjct: 651 KMELGKIRDGFVIPFNMPAIVELGTATGFDFELIDQAGLGHDALTQARNQLLGMAAQHPA 710 Query: 717 ELGPMFSSYQINVPQLNVDLDRVKAKQQGVAVTDVFNTMQIYLGSQYVNDFNRFGRVYQV 776 L + + + Q +++D+ KA+ GV+++D+ T+ LG YVNDF GRV ++ Sbjct: 711 SLVSVRPNGLEDTAQFKLEVDQEKAQALGVSLSDINQTISTALGGTYVNDFIDRGRVKKL 770 Query: 777 RAQADAPFRANPEDILQLKTRNSAGQMVPLSSLVNVTQTYGPEMVVRYNGYTSADINGGP 836 QADA FR PED+ +L R++ G+MVP S+ YG + RYNG S +I G Sbjct: 771 YVQADAKFRMLPEDVDKLYVRSANGEMVPFSAFTTSHWVYGSPRLERYNGLPSMEIQGEA 830 Query: 837 APGYSSSQAEAAVERIAAQTLPRGIKFEWTDLTYQKILAGNAGLWVFPISVLLVFLVLAA 896 APG SS A A +E +A++ LP GI ++WT ++YQ+ L+GN + IS ++VFL LAA Sbjct: 831 APGTSSGDAMALMENLASK-LPAGIGYDWTGMSYQERLSGNQAPALVAISFVVVFLCLAA 889 Query: 897 QYESLTLPLAVILIVPMGILAALTGVWLTGGDNNIFTQIGLMVLVGLACKNAILIVEFAR 956 YES ++P++V+L+VP+GI+ L L N+++ +GL+ +GL+ KNAILIVEFA+ Sbjct: 890 LYESWSIPVSVMLVVPLGIVGVLLAATLFNQKNDVYFMVGLLTTIGLSAKNAILIVEFAK 949 Query: 957 EL-EMQGATAFKAAVEASRLRLRPILMTSIAFIMGVVPLVTSTGAGSEMRHAMGIAVFFG 1015 +L E +G +A + A R+RLRPILMTS+AFI+GV+PL S GAGS ++A+GI V G Sbjct: 950 DLMEKEGKGVVEATLMAVRMRLRPILMTSLAFILGVLPLAISNGAGSGAQNAVGIGVMGG 1009 Query: 1016 MIGVTLFGLFLTPAFYVLIRTL 1037 M+ TL +F P F+V+IR Sbjct: 1010 MVSATLLAIFFVPVFFVVIRRC 1031 Score = 86.4 bits (214), Expect = 3e-19 Identities = 89/461 (19%), Positives = 171/461 (37%), Gaps = 40/461 (8%) Query: 610 VESAVAFP-GLSINGFTN-------SSSAGIVFVTLKPFDERKAKDLSANAIAGALNQKY 661 V+ V ++NG N S SAG V +TL F D++ + L Sbjct: 57 VQDTVTQVIEQNMNGIDNLMYMSSTSDSAGSVTITLT-FQSGTDPDIAQVQVQNKLQLAT 115 Query: 662 SAIQDAYIAVFPPPPVMGLGTMGGFKLQLE---DRGALGYSALNDAAQNFMKAAQSAPEL 718 + + + + + D ++D + +K L Sbjct: 116 PLLPQE----VQQQGISVEKSSSSYLMVAGFVSDNPGTTQDDISDYVASNVK-----DTL 166 Query: 719 GPMFSSYQINV----PQLNVDLDRVKAKQQGVAVTDVFNTM-----QIYLGSQYVNDFNR 769 + + + + + LD + + DV N + QI G Q Sbjct: 167 SRLNGVGDVQLFGAQYAMRIWLDADLLNKYKLTPVDVINQLKVQNDQIAAG-QLGGTPAL 225 Query: 770 FGRVYQVRAQADAPFRANPEDILQLKTR-NSAGQMVPLSSLVNVTQTYGP-EMVVRYNGY 827 G+ A F NPE+ ++ R NS G +V L + V ++ R NG Sbjct: 226 PGQQLNASIIAQTRF-KNPEEFGKVTLRVNSDGSVVRLKDVARVELGGENYNVIARINGK 284 Query: 828 TSADINGGPAPGYSSSQ-AEAAVERIA--AQTLPRGIKFEWT-DLTYQKILAGNAGLWVF 883 +A + A G ++ A+A ++A P+G+K + D T L+ + + Sbjct: 285 PAAGLGIKLATGANALDTAKAIKAKLAELQPFFPQGMKVLYPYDTTPFVQLSIHEVVKTL 344 Query: 884 PISVLLVFLVLAAQYESLTLPLAVILIVPMGILAALTGVWLTGGDNNIFTQIGLMVLVGL 943 +++LVFLV+ +++ L + VP+ +L + G N T G+++ +GL Sbjct: 345 FEAIMLVFLVMYLFLQNMRATLIPTIAVPVVLLGTFAILAAFGYSINTLTMFGMVLAIGL 404 Query: 944 ACKNAILIVE-FARELEMQGATAFKAAVEASRLRLRPILMTSIAFIMGVVPLVTSTGAGS 1002 +AI++VE R + +A ++ ++ ++ +P+ G+ Sbjct: 405 LVDDAIVVVENVERVMMEDKLPPKEATEKSMSQIQGALVGIAMVLSAVFIPMAFFGGSTG 464 Query: 1003 EMRHAMGIAVFFGMIGVTLFGLFLTPAF-YVLIRTLNSKHK 1042 + I + M L L LTPA L++ ++++H Sbjct: 465 AIYRQFSITIVSAMALSVLVALILTPALCATLLKPVSAEHH 505
>RTXTOXIND#Gram-negative bacterial RTX secretion protein D signature. Length = 478 Score = 48.7 bits (116), Expect = 2e-08 Identities = 19/99 (19%), Positives = 38/99 (38%), Gaps = 3/99 (3%) Query: 108 EAELNRAQAQLASAEAQVTYTGSNLSRIQRLIQSNAVSRQELDLAENDARSASANLQAAR 167 E + A +L ++Q+ S + + Q + L + R + N+ Sbjct: 258 ENKYVEAVNELRVYKSQLEQIESEILSAKEEYQLVTQLFKNEILDKL--RQTTDNIGLLT 315 Query: 168 AAVQSARLNLEYTRITAPVSGRISRAEV-TVGNVVSAGN 205 + + + I APVS ++ + +V T G VV+ Sbjct: 316 LELAKNEERQQASVIRAPVSVKVQQLKVHTEGGVVTTAE 354 Score = 47.9 bits (114), Expect = 4e-08 Identities = 18/108 (16%), Positives = 44/108 (40%), Gaps = 3/108 (2%) Query: 74 IRPQVSGKLISVHFKDGSLVRKGELLFTIDPRPFEAELNRAQAQLASAEAQVTYTGS--- 130 I+P + + + K+G VRKG++L + EA+ + Q+ L A + T Sbjct: 99 IKPIENSIVKEIIVKEGESVRKGDVLLKLTALGAEADTLKTQSSLLQARLEQTRYQILSR 158 Query: 131 NLSRIQRLIQSNAVSRQELDLAENDARSASANLQAARAAVQSARLNLE 178 ++ + +++E + ++ ++ + Q+ + E Sbjct: 159 SIELNKLPELKLPDEPYFQNVSEEEVLRLTSLIKEQFSTWQNQKYQKE 206
>PF03544#Gram-negative bacterial tonB protein Length = 243 Score = 27.2 bits (60), Expect = 0.050 Identities = 19/58 (32%), Positives = 23/58 (39%), Gaps = 4/58 (6%) Query: 41 PEPIILPSVEPIVLEQPKKPQINDIPKVEPEI---VAPVSIQ-AQPVIEPHNQVQAPV 94 +PI + V P LE P+ Q P VEPE P + A VIE P Sbjct: 47 AQPISVTMVAPADLEPPQAVQPPPEPVVEPEPEPEPIPEPPKEAPVVIEKPKPKPKPK 104
>ADHESNFAMILY#Adhesin family signature. Length = 309 Score = 29.4 bits (66), Expect = 0.016 Identities = 20/99 (20%), Positives = 37/99 (37%), Gaps = 18/99 (18%) Query: 20 QDYHVVVLNPKLGDINEQIRQHVVDADGMIGAGRVLNENNLAPAQKLKIISSVTVGYDNY 79 Q VV N + DI + I +D ++ G+ + + P + Sbjct: 31 QKLKVVATNSIIADITKNIAGDKIDLHSIVPIGQ--DPHEYEPLPE-------------- 74 Query: 80 DVAYLNQRKIWLANTPHVLTETTADLAFTLLLSAARKVP 118 DV ++ + N ++ ET + FT L+ A+K Sbjct: 75 DVKKTSEADLIFYNGINL--ETGGNAWFTKLVENAKKTE 111
>HTHTETR#TetR bacterial regulatory protein HTH signature. Length = 215 Score = 55.8 bits (134), Expect = 7e-12 Identities = 27/192 (14%), Positives = 55/192 (28%), Gaps = 6/192 (3%) Query: 21 RDQIVVAATEHFSRYGYEKTTVSDLAKSIGFSKAYIYKFFESKQAIGEMICANCLREIED 80 R I+ A FS+ G T++ ++AK+ G ++ IY F+ K + I I + Sbjct: 13 RQHILDVALRLFSQQGVSSTSLGEIAKAAGVTRGAIYWHFKDKSDLFSEIWELSESNIGE 72 Query: 81 EVNATIQE-AEYPAEKLRVLFK-----VIVEGSLRLFSQDRKLYEIAVSAASEKWDATVA 134 + P LR + + E RL + V + A Sbjct: 73 LELEYQAKFPGDPLSVLREILIHVLESTVTEERRRLLMEIIFHKCEFVGEMAVVQQAQRN 132 Query: 135 YENRILKVLQNIIQEGRQTGDFERKTPIDEAVKAIYLVMRPYLHPLLLQHSISYNADAPV 194 ++ ++ + A + + + L Sbjct: 133 LCLESYDRIEQTLKHCIEAKMLPADLMTRRAAIIMRGYISGLMENWLFAPQSFDLKKEAR 192 Query: 195 LLSSLVLRSLSP 206 +++L Sbjct: 193 DYVAILLEMYLL 204
>RTXTOXIND#Gram-negative bacterial RTX secretion protein D signature. Length = 478 Score = 45.2 bits (107), Expect = 2e-07 Identities = 20/135 (14%), Positives = 48/135 (35%), Gaps = 17/135 (12%) Query: 34 APLVRVATVQEEITSDSRAFTGTIGARVESDLGFRVSGKVIKRFVEAGQTVKRGQLLMRI 93 + VAT ++T R+ ++ V + V+ G++V++G +L+++ Sbjct: 78 GQVEIVATANGKLTHSGRSKE------IKPIENSIVK----EIIVKEGESVRKGDVLLKL 127 Query: 94 DPVDLELAAKAQQEAVGAAKARAE-------QAEKDEARYRDLRGSGAISASAYDQIKAA 146 + E Q ++ A+ E ++ L + +++ Sbjct: 128 TALGAEADTLKTQSSLLQARLEQTRYQILSRSIELNKLPELKLPDEPYFQNVSEEEVLRL 187 Query: 147 ADTARAQLSSTQAQA 161 + Q S+ Q Q Sbjct: 188 TSLIKEQFSTWQNQK 202
>ACRIFLAVINRP#Acriflavin resistance protein family signature. Length = 1034 Score = 436 bits (1124), Expect = e-139 Identities = 218/1047 (20%), Positives = 421/1047 (40%), Gaps = 63/1047 (6%) Query: 8 LSALAVRERGITLFLIFLISIAGIVAFFKLGRAEDPAFTVKVMTIVTAWPGATAQEMQDQ 67 ++ +R L ++ +AG +A +L A+ P +++ +PGA AQ +QD Sbjct: 1 MANFFIRRPIFAWVLAIILMMAGALAILQLPVAQYPTIAPPAVSVSANYPGADAQTVQDT 60 Query: 68 VAEKIEKRMQELRWYDRTETYT-RPGLAFTTLTLLDSTPPSQVQEEFYQARKKANDEISN 126 V + IE+ M + + + G TLT T P Q Q + K Sbjct: 61 VTQVIEQNMNGIDNLMYMSSTSDSAGSVTITLTFQSGTDPDIAQV---QVQNKLQLATPL 117 Query: 127 LPSGVIGPLVNDEYADVTFTLYAL--KAKNEAQRLLVRD--AETIRQQLLHVPGVKKVNI 182 LP V ++ E + ++ + A + + D A ++ L + GV V + Sbjct: 118 LPQEVQQQGISVEKSSSSYLMVAGFVSDNPGTTQDDISDYVASNVKDTLSRLNGVGDVQL 177 Query: 183 IGEQPERIYIEFSHERLATLGVNPQDVFAALNNQNVLTPAGSIET------KGPQVFVRL 236 G Q + I + L + P DV L QN AG + + + Sbjct: 178 FGAQ-YAMRIWLDADLLNKYKLTPVDVINQLKVQNDQIAAGQLGGTPALPGQQLNASIIA 236 Query: 237 DGAFDKLQKIRDTPI--TAQGRTLKLSDIATVKRGYEDPATFIIRNDGEPALLLGVVMRE 294 F ++ + + G ++L D+A V+ G E+ R +G+PA LG+ + Sbjct: 237 QTRFKNPEEFGKVTLRVNSDGSVVRLKDVARVELGGENYNVIA-RINGKPAAGLGIKLAT 295 Query: 295 GWNGLDLGKALENEVGSINEDLPLGISLNKVTDQAVNISSSVNEFMIKFFAALLVVMFVS 354 G N LD KA++ ++ + P G+ + D + S++E + F A+++V V Sbjct: 296 GANALDTAKAIKAKLAELQPFFPQGMKVLYPYDTTPFVQLSIHEVVKTLFEAIMLVFLVM 355 Query: 355 FISMG-WRVGLVVAMAVPLTLAIVFVAMLATGKNFDRITLGSLILALGLLVDDAIIAIEM 413 ++ + R L+ +AVP+ L F + A G + + +T+ ++LA+GLLVDDAI+ +E Sbjct: 356 YLFLQNMRATLIPTIAVPVVLLGTFAILAAFGYSINTLTMFGMVLAIGLLVDDAIVVVEN 415 Query: 414 MV-VKMEEGFSRIAASAYAWSHTAAPMLSGTLVTAVGFMPNGFARSTAGEYTSNMFWIVG 472 + V ME+ A+ + S ++ +V + F+P F + G + Sbjct: 416 VERVMMEDKLPPKEATEKSMSQIQGALVGIAMVLSAVFIPMAFFGGSTGAIYRQFSITIV 475 Query: 473 IALIASWIVAVVFTPYLGVKMLPDFKKVEGGHHA-----------IYDTPRYNRFRQILE 521 A+ S +VA++ TP L +L K V HH +D N + + Sbjct: 476 SAMALSVLVALILTPALCATLL---KPVSAEHHENKGGFFGWFNTTFD-HSVNHYTNSVG 531 Query: 522 RVIARKWLVAGSVIGLFVLAIGGMTLVKKQFFPISDRPEVLVEVQMPYGTSITQTSATTA 581 +++ + + + F P D+ L +Q+P G + +T Sbjct: 532 KILGSTGRYLLIYALIVAGMVVLFLRLPSSFLPEEDQGVFLTMIQLPAGATQERTQKVLD 591 Query: 582 KVEAWLSKQNEAKIVTSYIGQGAPRFYLSMGPELPDPSFAKIVI-----RTDNQEEREAL 636 +V + K NE V S S + + A + + R ++ EA+ Sbjct: 592 QVTDYYLK-NEKANVESVFTVNG----FSFSGQAQNAGMAFVSLKPWEERNGDENSAEAV 646 Query: 637 KHRLRQAV-----SNGLASEAQVRVTQLVFGPYSPYPVAYRVTGPDPEKLRVIAAQVQHV 691 HR + + + V + + G + L Q+ + Sbjct: 647 IHRAKMELGKIRDGFVIPFNMPAIVELGTATGFDFELID--QAGLGHDALTQARNQLLGM 704 Query: 692 MNASP-MMRTVNTDWGTRTPALHFTLQQDRLQAVGLTSASVAQQLQFLLTGIPITSVRED 750 P + +V + T + Q++ QA+G++ + + Q + L G + + Sbjct: 705 AAQHPASLVSVRPNGLEDTAQFKLEVDQEKAQALGVSLSDINQTISTALGGTYVNDFIDR 764 Query: 751 IRTVQVVARSAGDIRLDPAKIGDFTLTGANGQRIPLSQIGKIEVRMEEPVIRRRDRVPTI 810 R ++ ++ R+ P + + ANG+ +P S P + R + +P++ Sbjct: 765 GRVKKLYVQADAKFRMLPEDVDKLYVRSANGEMVPFSAFTTSHWVYGSPRLERYNGLPSM 824 Query: 811 TVRGDIAEGLQPPDVSTAITKQLQSVIKNLPKGYRIVEAGSIEESGKATKAMLPIFPIML 870 ++G+ A G D + +++ LP G G + + + I Sbjct: 825 EIQGEAAPGTSSGDAMALM----ENLASKLPAGIGYDWTGMSYQERLSGNQAPALVAISF 880 Query: 871 AMTLLIIILQVRSIAAMIMVFLTSPLGLIGVVPTLLLFQQPFGINALVGLIALSGILMRN 930 + L + S + + V L PLG++GV+ LF Q + +VGL+ G+ +N Sbjct: 881 VVVFLCLAALYESWSIPVSVMLVVPLGIVGVLLAATLFNQKNDVYFMVGLLTTIGLSAKN 940 Query: 931 TLILIGQIQQNKQA-GLDPLDAVVEATVQRARPVILTALAAILAFIPLTHSVFWGT---- 985 ++++ + + G ++A + A R RP+++T+LA IL +PL S G+ Sbjct: 941 AILIVEFAKDLMEKEGKGVVEATLMAVRMRLRPILMTSLAFILGVLPLAISNGAGSGAQN 1000 Query: 986 -LAYTLIGGTLAGTILTLVFLPAMYSI 1011 + ++GG ++ T+L + F+P + + Sbjct: 1001 AVGIGVMGGMVSATLLAIFFVPVFFVV 1027 Score = 80.3 bits (198), Expect = 2e-17 Identities = 57/325 (17%), Positives = 129/325 (39%), Gaps = 20/325 (6%) Query: 711 ALHFTLQQDRLQAVGLTSASVAQQLQF----LLTGIPITSVREDIRTVQVVARSAGDIRL 766 A+ L D L LT V QL+ + G + + + + + Sbjct: 183 AMRIWLDADLLNKYKLTPVDVINQLKVQNDQIAAGQLGGTPALPGQQLNASIIAQTRFK- 241 Query: 767 DPAKIGDFTL-TGANGQRIPLSQIGKIEVRMEEPVIRRR-DRVPTITVRGDIAEGLQPPD 824 +P + G TL ++G + L + ++E+ E + R + P + +A G D Sbjct: 242 NPEEFGKVTLRVNSDGSVVRLKDVARVELGGENYNVIARINGKPAAGLGIKLATGANALD 301 Query: 825 VSTAITKQLQSVIKNLPKGYRIVEA----GSIEESGKATKAMLPIFPIMLAMTLLIIILQ 880 + AI +L + P+G +++ ++ S L IML L++ L Sbjct: 302 TAKAIKAKLAELQPFFPQGMKVLYPYDTTPFVQLSIHEVVKTL-FEAIMLV--FLVMYLF 358 Query: 881 VRSIAAMIMVFLTSPLGLIGVVPTLLLFQQPFGINALVGLIALSGILMRNTLILIGQIQQ 940 ++++ A ++ + P+ L+G L F + G++ G+L+ + ++++ +++ Sbjct: 359 LQNMRATLIPTIAVPVVLLGTFAILAAFGYSINTLTMFGMVLAIGLLVDDAIVVVENVER 418 Query: 941 -NKQAGLDPLDAVVEATVQRARPVILTALAAILAFIPL-----THSVFWGTLAYTLIGGT 994 + L P +A ++ Q ++ A+ FIP+ + + + T++ Sbjct: 419 VMMEDKLPPKEATEKSMSQIQGALVGIAMVLSAVFIPMAFFGGSTGAIYRQFSITIVSAM 478 Query: 995 LAGTILTLVFLPAMYSIWFKIRVKP 1019 ++ L+ PA+ + K Sbjct: 479 ALSVLVALILTPALCATLLKPVSAE 503
>DHBDHDRGNASE#2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase signature. Length = 261 Score = 97.8 bits (243), Expect = 2e-26 Identities = 51/186 (27%), Positives = 83/186 (44%), Gaps = 8/186 (4%) Query: 5 QVVVITGVSSGIGQVTAEKFAKKGHKVFGTVRNKVKAQPIEGVELIE--------MDVSD 56 ++ ITG + GIG+ A A +G + N K + + E DV D Sbjct: 9 KIAFITGAAQGIGEAVARTLASQGAHIAAVDYNPEKLEKVVSSLKAEARHAEAFPADVRD 68 Query: 57 EDSVQLGIHSIIDKAGRIDILINNAGASLTGAIEETSIKEAEFLFNTNVFSILRTIQAVL 116 ++ I + G IDIL+N AG G I S +E E F+ N + ++V Sbjct: 69 SAAIDEITARIEREMGPIDILVNVAGVLRPGLIHSLSDEEWEATFSVNSTGVFNASRSVS 128 Query: 117 PYMRIQHYGRIINISSVLGFLPSPYMGVYSATKHAVEGLSESLDHELRQFGIRVTLVQPS 176 YM + G I+ + S +P M Y+++K A ++ L EL ++ IR +V P Sbjct: 129 KYMMDRRSGSIVTVGSNPAGVPRTSMAAYASSKAAAVMFTKCLGLELAEYNIRCNIVSPG 188 Query: 177 FTKTNL 182 T+T++ Sbjct: 189 STETDM 194
>TCRTETA#Tetracycline resistance protein signature. Length = 399 Score = 52.9 bits (127), Expect = 7e-10 Identities = 66/345 (19%), Positives = 125/345 (36%), Gaps = 21/345 (6%) Query: 19 GHFISAYALGVVIGAPIIAILGAKVPRKTLLLGLMLFYGVANACTALAHTPETVLISRFI 78 G ++ YAL AP++ L + R+ +LL + V A A A + I R + Sbjct: 46 GILLALYALMQFACAPVLGALSDRFGRRPVLLVSLAGAAVDYAIMATAPFLWVLYIGRIV 105 Query: 79 AGLPHGAYFGVGALVAAELAGPSRRASAVAQMMMGLTVATVIGVPLATWLGQNFGWRAGF 138 AG+ GA V A++ RA M V G L +G F A F Sbjct: 106 AGIT-GATGAVAGAYIADITDGDERARHFGFMSACFGFGMVAGPVLGGLMGG-FSPHAPF 163 Query: 139 EFSATIAFVTLIAVGFFVPNIPVQATAS-----IKTELAGLKNINMWLTLAVGAIGFGGM 193 +A + + + F +P + LA + +A F M Sbjct: 164 FAAAALNGLNFLTGCFLLPE-SHKGERRPLRREALNPLASFRWARGMTVVAALMAVFFIM 222 Query: 194 FSVYSYVSPILTEYTQ----VNIQIVPIALAIWGI-GMVIGGLAAGWLADKNLNKTIVGV 248 V + + + + + + I+LA +GI + + G +A + + + + Sbjct: 223 QLVGQVPAALWVIFGEDRFHWDATTIGISLAAFGILHSLAQAMITGPVAARLGERRALML 282 Query: 249 -LISSAIAFVVASFLMSNIYSAIASLFLIGLTVMGLGGALQTRL-MDVAGDAQTLAASLN 306 +I+ +++ +F + + A + L+ +G+ ALQ L V + Q Sbjct: 283 GMIADGTGYILLAFA-TRGWMAFPIMVLLASGGIGM-PALQAMLSRQVDEERQGQLQGSL 340 Query: 307 HSAFNMANALGAFLGGWVLSHQMGWIAPIWVGFVLSLGGLIILLI 351 + ++ + +G L + + W G+ G + LL Sbjct: 341 AALTSLTSIVGPLLFTAIYAAS----ITTWNGWAWIAGAALYLLC 381
>PF00577#Outer membrane usher protein FimD Length = 878 Score = 295 bits (756), Expect = 2e-89 Identities = 146/797 (18%), Positives = 275/797 (34%), Gaps = 72/797 (9%) Query: 62 LNVSINSN--ASED--LVAAKQSKDGKLFIRSGVLKTLRLKIDEQLPDSQW---VCIN-- 112 +++ +N+ A+ D + + L ++ L + C+ Sbjct: 80 VDIYLNNGYMATRDVTFNTGDSEQGIVPCLTRAQLASMGLNTASVSGMNLLADDACVPLT 139 Query: 113 -ELKGIQFKYLENEQALNLQVPSSMLTGYSVDLSGQKVTSPHLLKMKPLTAAILNYSLY- 170 + + +Q LNL +P + ++ + P L + A +LNY+ Sbjct: 140 SMIHDATAQLDVGQQRLNLTIPQAFMS-----NRARGYIPPELWD-PGINAGLLNYNFSG 193 Query: 171 NTITNDENVFSGSAEGIFNSAIGNFSSGVL-------YNGSNETSYSHEKWVRLESKWQY 223 N++ N S A S + N + L YN S+ +S S KW + + + Sbjct: 194 NSVQNRIGGNSHYAYLNLQSGL-NIGAWRLRDNTTWSYNSSDSSSGSKNKWQHINTWLER 252 Query: 224 VDPEKVRIYTLGDFISNSSDWGNSVRLAGFQWSSAYTQRGDIVTSAFPQFSGSAALPSTL 283 TLGD + + + G Q +S D P G A + + Sbjct: 253 DIIPLRSRLTLGDGYTQGDIFD-GINFRGAQLASDDNMLPDSQRGFAPVIHGIARGTAQV 311 Query: 284 DLYVNQQKIYSGLVPSGPFDIKQLPFISG-NEVTLVTTDATGQQSITKQAYYFSSKILAK 342 + N IY+ VP GPF I + ++ + +A G I Y + + Sbjct: 312 TIKQNGYDIYNSTVPPGPFTINDIYAAGNSGDLQVTIKEADGSTQIFTVPYSSVPLLQRE 371 Query: 343 GINEFSVDVGVPRYNYGLFSNDYDDATFASGAIRYGYSNSLTLSGGAEASTDGLSNLGTG 402 G +S+ G R + F + +G T+ GG + + D G Sbjct: 372 GHTRYSITAGEYRSGNAQ----QEKPRFFQSTLLHGLPAGWTIYGGTQLA-DRYRAFNFG 426 Query: 403 FAKNLFGFGVINADIAASQYKDENGYSALVGLEGRISKNISFN--------TSYRKVFDN 454 KN+ G ++ D+ + + S G R N S N YR Sbjct: 427 IGKNMGALGALSVDMTQANSTLPDD-SQHDGQSVRFLYNKSLNESGTNIQLVGYRYSTSG 485 Query: 455 YFDLARVSQIRY------LKDNQMTSEPQNYLSYSALADEIFRAGMSYN--FYEGYSAYL 506 YF+ A + R +D + +P+ Y+ ++ + ++ + YL Sbjct: 486 YFNFADTTYSRMNGYNIETQDGVIQVKPKFTDYYNLAYNKRGKLQLTVTQQLGRTSTLYL 545 Query: 507 GYNQIKY--SDNANKLVSANLSGTLNN-NWGFYASAYKD-YENQKDYGIYFAL------- 555 + Y + N ++ A L+ + NW S K+ ++ +D + + Sbjct: 546 SGSHQTYWGTSNVDEQFQAGLNTAFEDINWTLSYSLTKNAWQKGRDQMLALNVNIPFSHW 605 Query: 556 ----RYTPSTRVNAITSVSSD-NGSLRYRQELFGLSEPQIGSFGWG---GYVERDQDAQE 607 + +A S+S D NG + ++G + + + + GY Sbjct: 606 LRSDSKSQWRHASASYSMSHDLNGRMTNLAGVYG-TLLEDNNLSYSVQTGYAGGGDGNSG 664 Query: 608 NNASIYGSYRARAAYLTGRYNRIGDNDQVAVSATGSLVAAAGRIFAANEIGDGYAVVTNA 667 + +YR Y+ D Q+ +G ++A A + + D +V Sbjct: 665 STGYATLNYRGGYGNANIGYSHSDDIKQLYYGVSGGVLAHANGVTLGQPLNDTVVLVKAP 724 Query: 668 GPQSQILNGGVNLGTTDKSGRFLIPSLMPYRENHIYLDPSYLPLNWSVKSTDQKTVVGYR 727 G + + TD G ++P YREN + LD + L N + + V Sbjct: 725 GAKDAKVENQ-TGVRTDWRGYAVLPYATEYRENRVALDTNTLADNVDLDNAVANVVPTRG 783 Query: 728 QGGLIDFGAHQVISGLVKLVDQNNSPLLPGYTVR-INGQQEGVVGYDGEVFIPNLLKQNQ 786 +F A I L+ + NN PL G V + Q G+V +G+V++ + + Sbjct: 784 AIVRAEFKARVGIKLLM-TLTHNNKPLPFGAMVTSESSQSSGIVADNGQVYLSGMPLAGK 842 Query: 787 LEVDLLDHGSCQVDFTY 803 ++V + + Y Sbjct: 843 VQVKWGEEENAHCVANY 859
>2FE2SRDCTASE#Ferric iron reductase signature. Length = 262 Score = 30.8 bits (69), Expect = 0.003 Identities = 11/35 (31%), Positives = 17/35 (48%), Gaps = 3/35 (8%) Query: 64 STRIARYLEETYPDTPRLYPEDPNQKALAELWEDW 98 S+ +A Y + Y + P + E+ K L LW W Sbjct: 67 SSLLAVYSDHIYRNQPMMIREN---KPLISLWAQW 98
>DHBDHDRGNASE#2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase signature. Length = 261 Score = 54.7 bits (131), Expect = 5e-11 Identities = 37/173 (21%), Positives = 72/173 (41%), Gaps = 10/173 (5%) Query: 8 KKIDCAVVIGVGALQGIGAAVSHRFAKEGLKVYVAGRTFQKIEAVAAEIHSKGGDAVAFR 67 K I+ + GA QGIG AV+ A +G + +K+E V + + ++ A AF Sbjct: 4 KGIEGKIAFITGAAQGIGEAVARTLASQGAHIAAVDYNPEKLEKVVSSLKAEARHAEAFP 63 Query: 68 LDAEDIKQVQALFDTITSQNERITAVIHNVGGNIPSIFLRSPL-SFFTQMWQSTF----L 122 D D + + I + I ++ N+ + + S + W++TF Sbjct: 64 ADVRDSAAIDEITARIEREMGPIDILV-----NVAGVLRPGLIHSLSDEEWEATFSVNST 118 Query: 123 SAYLVSQICLKIFKDQNHGTLIFTGASASLRGKPFFAAFTMGKSALRAYALNL 175 + S+ K D+ G+++ G++ + + AA+ K+A + L Sbjct: 119 GVFNASRSVSKYMMDRRSGSIVTVGSNPAGVPRTSMAAYASSKAAAVMFTKCL 171
>HTHTETR#TetR bacterial regulatory protein HTH signature. Length = 215 Score = 47.3 bits (112), Expect = 5e-09 Identities = 23/128 (17%), Positives = 42/128 (32%), Gaps = 3/128 (2%) Query: 12 RVLHVARNLFNQYGFNNVGVDRIVKDAKIPKATFYNCFSCKEKLVEMCLTFQKDALKDEV 71 +L VA LF+Q G ++ + I K A + + Y F K L + + E+ Sbjct: 15 HILDVALRLFSQQGVSSTSLGEIAKAAGVTRGAIYWHFKDKSDLFSEIWELSESNI-GEL 73 Query: 72 FSIIHSYRELMVFDKLKKIF--FLHADLEGFYHLQFKAIFEIEKLYPTAYKIVSDYRNWF 129 + L++I L + + I + + +V + Sbjct: 74 ELEYQAKFPGDPLSVLREILIHVLESTVTEERRRLLMEIIFHKCEFVGEMAVVQQAQRNL 133 Query: 130 IKEIYKLI 137 E Y I Sbjct: 134 CLESYDRI 141
>SACTRNSFRASE#Streptothricin acetyltransferase signature. Length = 173 Score = 38.8 bits (90), Expect = 3e-06 Identities = 27/119 (22%), Positives = 51/119 (42%), Gaps = 12/119 (10%) Query: 23 AFQNAEHTSHTEHFIVNSLRNYG--QLTISLVAVEDGSIIGHVA----ISPVQISSGEIG 76 AF+N T E F + Y + +S V E + + I ++I S G Sbjct: 29 AFENGVWTYTEERFSKPYFKQYEDDDMDVSYVEEEGKAAFLYYLENNCIGRIKIRSNWNG 88 Query: 77 WYGLGPISVHPDKQGLGIGSLLMNKSLEKLKNLGAKGCVL------LDDPNYYSRFGFK 129 + + I+V D + G+G+ L++K++E K G +L + ++Y++ F Sbjct: 89 YALIEDIAVAKDYRKKGVGTALLHKAIEWAKENHFCGLMLETQDINISACHFYAKHHFI 147
>OUTRMMBRANEA#Outer membrane protein A signature. Length = 346 Score = 33.0 bits (75), Expect = 0.002 Identities = 42/191 (21%), Positives = 61/191 (31%), Gaps = 36/191 (18%) Query: 200 TLGQAIPITN---LGNKSKAAS------IRAWTPTIEAQYQFGKSGINKFRPYVGVGLMY 250 T+ QA P N G K + I PT E Q G G + PYVG + Y Sbjct: 17 TVAQAAPKDNTWYTGAKLGWSQYHDTGFINNNGPTHENQLGAGAFGGYQVNPYVGFEMGY 76 Query: 251 AHFNDIKLNDGIRSDLVSA---------GHMIQNVLD--GKAGAALDRKESSGKMVVDVN 299 + + + A G+ I + LD + G + R ++ V N Sbjct: 77 DWLGRMPYKGSVENGAYKAQGVQLTAKLGYPITDDLDIYTRLGGMVWRADTKSN-VYGKN 135 Query: 300 ADDAIAPIFTAGFTYDFNDSWYTVASVSYAKLSNNAQIDVVNQNTGTRLIHATTKVDIDP 359 D ++P+F G Y T + +A + G Sbjct: 136 HDTGVSPVFAGGVEYAITPEIATRLEYQWTNNIGDAHTIGTRPDNGM------------- 182 Query: 360 LITYLGVGYRF 370 LGV YRF Sbjct: 183 --LSLGVSYRF 191
>PF03544#Gram-negative bacterial tonB protein Length = 243 Score = 29.6 bits (66), Expect = 0.014 Identities = 8/102 (7%), Positives = 16/102 (15%), Gaps = 6/102 (5%) Query: 99 ELLNQKVDPESAQSDNP----TNSDTPATASTETPAVENKVVNAAPTGTPSTTPPPQPEA 154 ++ P + E P V+ P + Sbjct: 53 TMVAPADLEPPQAVQPPPEPVVEPEPEPEPIPEPPKEAPVVIEKPKPKPKPKPKPVKKVE 112 Query: 155 SQPPS--QNQSNPIELEKAAYTVALDAYKQGGAKKAIAPMQN 194 +S P + + A Sbjct: 113 QPKRDVKPVESRPASPFENTAPARPTSSTATAATSKPVTSVA 154
>BACTRLTOXIN#Bacterial toxin signature. Length = 266 Score = 25.3 bits (55), Expect = 0.046 Identities = 12/42 (28%), Positives = 23/42 (54%) Query: 37 LLNIKELTNEHHPLVTQAFTTDHFENHNMAGNVIKKALHGFD 78 + N+K L ++H+ T+ + D F H++ N+ K L +D Sbjct: 48 MGNMKYLYDDHYVSATKVKSVDKFLAHDLIYNISDKKLKNYD 89
>PF07132#Harpin protein (HrpN) Length = 356 Score = 35.1 bits (80), Expect = 9e-04 Identities = 38/94 (40%), Positives = 45/94 (47%), Gaps = 6/94 (6%) Query: 260 GGLLGSLGKLLTSALSAGGGLLGGVLGKGKKGVGKLGKGLGKLLKFGRGLPVIGALAAGA 319 GGL G LG L +S GGGLLGG LG G LG GLG L G G GAL AG Sbjct: 67 GGLGGGLGGLGSSLGGLGGGLLGGGLGGG--LGSSLGSGLGSALGGGLG----GALGAGM 120 Query: 320 SLLDWNEQSTQEKGGTVGSLAGGAIGGTVGSLFG 353 + ++ + + L GG + G LFG Sbjct: 121 NAMNPSAMMGSLLFSALEDLLGGGMSQQQGGLFG 154
>TATBPROTEIN#Bacterial sec-independent translocation TatB protein signature. Length = 171 Score = 29.2 bits (65), Expect = 0.013 Identities = 11/49 (22%), Positives = 21/49 (42%), Gaps = 1/49 (2%) Query: 175 FDDAKKYLETMPLQELAPTERDTLQRLEKFVDNLAARYPAL-ENPLAYE 222 F D+ K +E L L P + ++ L + +++ Y A + E Sbjct: 59 FQDSLKKVEKASLTNLTPELKASMDELRQAAESMKRSYVANDPEKASDE 107
>TCRTETA#Tetracycline resistance protein signature. Length = 399 Score = 29.4 bits (66), Expect = 0.027 Identities = 50/305 (16%), Positives = 101/305 (33%), Gaps = 18/305 (5%) Query: 61 WMSRVGRKAGFITGTLSGVVAAIISIVAMIQHSFMLLCLGMLFLGIYQAFAQFYRFAAAE 120 R GR+ + AA+ + +L +G + GI A A+ Sbjct: 66 LSDRFGRRPVLLVSLAG---AAVDYAIMATAPFLWVLYIGRIVAGITGATGAVAGAYIAD 122 Query: 121 IAPPVFRTKAISLVLA----GGVIAALLGPFLASIGSTLFSVAYMGSFLFMGILASLGLL 176 I R + + A G V +LG + + + G+ G Sbjct: 123 ITDGDERARHFGFMSACFGFGMVAGPVLGGLMGGFSPHA---PFFAAAALNGLNFLTGCF 179 Query: 177 LLSRLQIPMQSNDLTEQ---VLSRPWIKVISQPAYLVALFSGASGFGIMVLGLTATPIAM 233 LL + E + S W + ++ A L+A+F G + L Sbjct: 180 LLPESHKGERRPLRREALNPLASFRWARGMTVVAALMAVFFIMQLVGQVPAALWVIFGED 239 Query: 234 KHYGFDLSQIAAVIQ-LHILGRFIPSFFTAKLIDRFGVIKIMLVGILL-LIAYIIVVLSG 291 + + +D + I + IL + T + R G + +++G++ YI++ + Sbjct: 240 R-FHWDATTIGISLAAFGILHSLAQAMITGPVAARLGERRALMLGMIADGTGYILLAFAT 298 Query: 292 VTWGFFAAALILMGIGWNFLYIGGTSLLATTYSTGEKGVAQAANDMSVFIFSVICSLGAG 351 W F ++L G + ++L+ +G Q + + S++ L Sbjct: 299 RGWMAFPIMVLLASGGIGMPAL--QAMLSRQVDEERQGQLQGSLAALTSLTSIVGPLLFT 356 Query: 352 PLLNL 356 + Sbjct: 357 AIYAA 361
>RTXTOXINA#Gram-negative bacterial RTX toxin determinant A family signature. Length = 1024 Score = 27.6 bits (61), Expect = 0.010 Identities = 15/77 (19%), Positives = 33/77 (42%), Gaps = 9/77 (11%) Query: 18 DLSLLIKFYRLEKNMRQVDLAEA-VEVSLSTIKRIENADTSVET--------GALLKTIW 68 + LIK + N+ +LA+A +E+ + + + + +V + G++L Sbjct: 161 KIDELIKKQKSGGNVSSSELAKASIELINQLVDTVASLNNNVNSFSQQLNTLGSVLSNTK 220 Query: 69 YLGILDQLSQALPKIKK 85 +L + Q LP + Sbjct: 221 HLNGVGNKLQNLPNLDN 237
>GPOSANCHOR#Gram-positive coccus surface protein anchor signature. Length = 539 Score = 43.9 bits (103), Expect = 1e-05 Identities = 55/421 (13%), Positives = 136/421 (32%), Gaps = 31/421 (7%) Query: 126 QTGNSTLTGNSSVVGDTSVAGNSAVAGSMAVGTTLTVAGIPIDPKAFQGALQDAIDKLEE 185 +TG +++ +V+G V + V+ T T+ + F+ K + Sbjct: 16 KTGTASVAVALTVLGAGLVVNTNEVSAVATRSQTDTLEKVQERADKFEIENNTLKLKNSD 75 Query: 186 LKEELKEQGEKIDENKDQVSQEIDEKIKEVEELIENIKDSDAYKLLEEGINHIDEEVQKI 245 L K + DE +++S ++ K + L S+ ++E + + + Sbjct: 76 LSFNNKALKDHNDELTEELSNAKEKLRKNDKSL------SEKASKIQELEARKADLEKAL 129 Query: 246 HDQVKEVGKEAQSKIDEVRAYIDQEIIDTKLIVEQHTNDANLRLDEANQRIDQSVQANEA 305 + +KI + A + + N ++ + ++++A +A Sbjct: 130 EGAMNFS-TADSAKIKTLEAEKAALAARKADLEKALEGAMNFSTADSAKI--KTLEAEKA 186 Query: 306 MVADAQQRAIRAEKELDDKIGFIKSETDSIIADVRSDSDEIRLVAENAKKVADQEIIDRK 365 + Q +A + + ++ ++ A+ + + + + + + Sbjct: 187 ALEARQAELEKALEGAMNFSTADSAKIKTLEAEKAALAARKADLEKALEGAMNFS----- 241 Query: 366 KQVDEALIVVDQTKAALKQDIDQNLIKAGQMVDAAKLAMGEQTNTLINQKIEPIVSQTES 425 + ++ KAAL+ + ++ + + + Sbjct: 242 TADSAKIKTLEAEKAALEARQAELEKALEGAMNFSTADSAKIKTLEAEKAALEAEKADLE 301 Query: 426 TVKRVDQVAAQYVDLDKKVTTGFLAEAEARANDKEAITQSFELKFSEMQNELGKSTALIS 485 +V Q + D + + EA E + E ++ +L S Sbjct: 302 HQSQVLNANRQSLRRDLDASREAKKQLEAEHQKLEEQNKISEASRQSLRRDLDASRE--- 358 Query: 486 EESKTRAAQDKAFTE-QISSAQSQIGDNKAAINSVERTVVELDKSVAEKTGQLQASLDTA 544 + + A K + +IS A S + +LD S K Q++ +L+ A Sbjct: 359 AKKQLEAEHQKLEEQNKISEA------------SRQSLRRDLDASREAKK-QVEKALEEA 405 Query: 545 N 545 N Sbjct: 406 N 406
>GPOSANCHOR#Gram-positive coccus surface protein anchor signature. Length = 539 Score = 36.2 bits (83), Expect = 4e-04 Identities = 30/203 (14%), Positives = 66/203 (32%), Gaps = 7/203 (3%) Query: 307 LAGRIMKLINQNSNRFKRLQAKKAEKAKALADAESRIEQKQNQLNSLNAEISNLLNDLDQ 366 L L + ++ K L+ A + +E ++ L + AE+ L Sbjct: 146 LEAEKAALAARKADLEKALEGAMNFS-TADSAKIKTLEAEKAALEARQAELEKALEGAMN 204 Query: 367 LQTSLQSKQSEENEEIIEENSLNDNSPDSISHEEAER--LRADLKRLNADPQWAGEDGLR 424 T+ +K E + + ++ A +K L A+ Sbjct: 205 FSTADSAKIKTLEAEKAALAARKADLEKALEGAMNFSTADSAKIKTLEAEKAALEAR--- 261 Query: 425 YQAFYERINKAVEGDSEAVSWARKWISELDEQDLAQQQAELESKKLIEAEIEANQKRDEE 484 QA E+ + S A S K + A++ +++ A ++ ++ + Sbjct: 262 -QAELEKALEGAMNFSTADSAKIKTLEAEKAALEAEKADLEHQSQVLNANRQSLRRDLDA 320 Query: 485 VLAARSAGMAENKMMQAWLDTLE 507 A+ AE++ ++ E Sbjct: 321 SREAKKQLEAEHQKLEEQNKISE 343 Score = 32.3 bits (73), Expect = 0.006 Identities = 38/187 (20%), Positives = 73/187 (39%), Gaps = 8/187 (4%) Query: 309 GRIMKLINQNSNRFKRLQAKKAEKAKALADAESRIEQKQNQLNSLNAEISNLLNDLDQLQ 368 + K + N AK A E+ ++Q LNA +L DLD + Sbjct: 263 AELEKALEGAMNFSTADSAKIKTLEAEKAALEAEKADLEHQSQVLNANRQSLRRDLDASR 322 Query: 369 TSLQSKQSE----ENEEIIEENSLNDNSPD-SISHEEAERLRADLKRLNADPQWAGEDGL 423 + + ++E E + I E S D S E ++L A+ ++L + + Sbjct: 323 EAKKQLEAEHQKLEEQNKISEASRQSLRRDLDASREAKKQLEAEHQKLEEQNKISEASRQ 382 Query: 424 RYQAFYER---INKAVEGDSEAVSWARKWISELDEQDLAQQQAELESKKLIEAEIEANQK 480 + + K VE E + + +L+++ ++ + K ++A++EA K Sbjct: 383 SLRRDLDASREAKKQVEKALEEANSKLAALEKLNKELEESKKLTEKEKAELQAKLEAEAK 442 Query: 481 RDEEVLA 487 +E LA Sbjct: 443 ALKEKLA 449
>NUCEPIMERASE#Nucleotide sugar epimerase signature. Length = 334 Score = 29.4 bits (66), Expect = 0.028 Identities = 16/76 (21%), Positives = 29/76 (38%), Gaps = 11/76 (14%) Query: 268 KLGKQHNLVLGISELKDGYLKSLKAYGFTKYHQKIYKNTNYQFLNSKLNDLKVLNEALSE 327 +L + + V+GI L D Y SLK + ++ +QF L D + + + + Sbjct: 19 RLLEAGHQVVGIDNLNDYYDVSLK-----QARLELLAQPGFQFHKIDLADREGMTDLFAS 73 Query: 328 SKLDY------RAGVP 337 + R V Sbjct: 74 GHFERVFISPHRLAVR 89
>SACTRNSFRASE#Streptothricin acetyltransferase signature. Length = 173 Score = 39.5 bits (92), Expect = 5e-06 Identities = 20/84 (23%), Positives = 34/84 (40%), Gaps = 2/84 (2%) Query: 209 IWLAIKNNKIVGSVAIDGEDLGNNEAHLRWFILSDDCRGQGIGKKLLKEAINFCDQKQFS 268 +L N +G + I N A + ++ D R +G+G LL +AI + + F Sbjct: 67 AFLYYLENNCIGRIKIRSN--WNGYALIEDIAVAKDYRKKGVGTALLHKAIEWAKENHFC 124 Query: 269 AVQLWTFSGLSAARKLYETFGFKL 292 + L T +A Y F + Sbjct: 125 GLMLETQDINISACHFYAKHHFII 148
>TCRTETA#Tetracycline resistance protein signature. Length = 399 Score = 47.1 bits (112), Expect = 8e-08 Identities = 39/179 (21%), Positives = 64/179 (35%), Gaps = 5/179 (2%) Query: 33 IICFLIIFTDGIDTAAMGFIAPALAQDWGVDRSQ---LGPVMSAALGGMIIGALVSGPTA 89 I+ + D + + + P L +D G +++ A V G + Sbjct: 8 IVILSTVALDAVGIGLIMPVLPGLLRDLVHSNDVTAHYGILLALYALMQFACAPVLGALS 67 Query: 90 DRFGRKIVLAFSMLVFGGFTLASAYATNLDSLVVLRFLTGIGLGAAMPNATTLFSEYCPT 149 DRFGR+ VL S+ A A L L + R + GI GA A ++ Sbjct: 68 DRFGRRPVLLVSLAGAAVDYAIMATAPFLWVLYIGRIVAGIT-GATGAVAGAYIADITDG 126 Query: 150 RIRSLLVTCMFCGYNLGMATGGFISSWLIPTYGWHSLFLLGGWSPLILMVLVIFVLPES 208 R+ M + GM G + + + H+ F + + F+LPES Sbjct: 127 DERARHFGFMSACFGFGMVAGPVLGGLM-GGFSPHAPFFAAAALNGLNFLTGCFLLPES 184 Score = 29.0 bits (65), Expect = 0.037 Identities = 33/132 (25%), Positives = 53/132 (40%), Gaps = 11/132 (8%) Query: 289 LPTLMRETGASMERAAFIG---GLFQFGGVVSALFIGWAMDKFNPNRVIAIFYFAAGLFA 345 LP L+R+ S + A G L+ A +G D+F V+ + L Sbjct: 28 LPGLLRDLVHSNDVTAHYGILLALYALMQFACAPVLGALSDRFGRRPVLLV-----SLAG 82 Query: 346 IAVGQSL-GNSTLLAVLVLCAGIA-INGAQSSMP-ALSARFYPTQCRATGVSWMTGIGRF 402 AV ++ + L VL + +A I GA ++ A A RA +M+ F Sbjct: 83 AAVDYAIMATAPFLWVLYIGRIVAGITGATGAVAGAYIADITDGDERARHFGFMSACFGF 142 Query: 403 GAVFGAWIGAVL 414 G V G +G ++ Sbjct: 143 GMVAGPVLGGLM 154
>NUCEPIMERASE#Nucleotide sugar epimerase signature. Length = 334 Score = 27.8 bits (62), Expect = 0.047 Identities = 11/25 (44%), Positives = 15/25 (60%) Query: 1 MRIAVTGASGQLGQLVISQLLERTD 25 M+ VTGA+G +G V +LLE Sbjct: 1 MKYLVTGAAGFIGFHVSKRLLEAGH 25
>HTHTETR#TetR bacterial regulatory protein HTH signature. Length = 215 Score = 63.1 bits (153), Expect = 1e-14 Identities = 31/180 (17%), Positives = 65/180 (36%), Gaps = 15/180 (8%) Query: 5 ERSSKKLHVIHTAIELFNLYGFHNTGVDLIAKESKIPKATFYNYFHSKEQLIERCVSFQK 64 E + H++ A+ LF+ G +T + IAK + + + Y +F K L + Sbjct: 8 EAQETRQHILDVALRLFSQQGVSSTSLGEIAKAAGVTRGAIYWHFKDKSDLFSEIWELSE 67 Query: 65 SRLKEEVLAIIYSSCYRTSSDKLKEIIVLHVNF---NSLYYLLLKAIFE----------I 111 S + E L + L+EI++ + LL++ IF + Sbjct: 68 SNIGELELEYQ-AKFPGDPLSVLREILIHVLESTVTEERRRLLMEIIFHKCEFVGEMAVV 126 Query: 112 KKIYSQAYQMAIEYRKWLLRELFDLVFSLENNTLKPDANMVLNLIDGLMFQ-ILSSNRLD 170 ++ + + + L+ + + + A ++ I GLM + + D Sbjct: 127 QQAQRNLCLESYDRIEQTLKHCIEAKMLPADLMTRRAAIIMRGYISGLMENWLFAPQSFD 186
>HTHTETR#TetR bacterial regulatory protein HTH signature. Length = 215 Score = 50.0 bits (119), Expect = 8e-10 Identities = 19/62 (30%), Positives = 32/62 (51%), Gaps = 2/62 (3%) Query: 18 REALLINGLQLLESSQGVD-FSMRELTRMIGVSPNAVYRHFANKEELLTALAIYGFEQLI 76 R+ +L L+L S QGV S+ E+ + GV+ A+Y HF +K +L + + + Sbjct: 13 RQHILDVALRLF-SQQGVSSTSLGEIAKAAGVTRGAIYWHFKDKSDLFSEIWELSESNIG 71 Query: 77 EA 78 E Sbjct: 72 EL 73
>YERSSTKINASE#Yersinia serine/threonine protein kinase signature. Length = 732 Score = 28.6 bits (63), Expect = 0.022 Identities = 14/31 (45%), Positives = 22/31 (70%), Gaps = 3/31 (9%) Query: 54 VSLEDFGFVNRLSDGRYTLASEVMRLNTIYQ 84 VS E +GF+NRL++ + TL+ + LNT+ Q Sbjct: 586 VSSETYGFLNRLTEAKITLSQQ---LNTLQQ 613
>RTXTOXINA#Gram-negative bacterial RTX toxin determinant A family signature. Length = 1024 Score = 75.0 bits (184), Expect = 6e-16 Identities = 62/218 (28%), Positives = 88/218 (40%), Gaps = 12/218 (5%) Query: 280 GGDGNDTLISNTGTDYLYGGAGNDTLVYGGNSNAYTALLGQAGND--TYIIDKVLLTSSS 337 GDG+D + + G+ +Y G G+D + Y Y + G + Y + +VL Sbjct: 616 LGDGDDKVFLSAGSANIYAGKGHDVVYYDKTDTGYLTIDGTKATEAGNYTVTRVLGGDVK 675 Query: 338 YIHILDNAAEENTLQLKSVLSSDILLKQSDSLIIISFNDSASTIRFGKDNLSSIVFDDGT 397 + E Q SV + F DNL S+ GT Sbjct: 676 VLQ------EVVKEQEVSVGKRTEKTQYRSY----EFTHINGKNLTETDNLYSVEELIGT 725 Query: 398 VWDKAQIEANTIGKLLGTDEADALQADAEISTIYGLGGNDTIQGGVQNDYLYGGDGDDTL 457 + G D D ++ + +YG GNDT+ GG +D LYGGDG+D L Sbjct: 726 TRADKFFGSKFTDIFHGADGDDLIEGNDGNDRLYGDKGNDTLSGGNGDDQLYGGDGNDKL 785 Query: 458 ISNTGSDYLYGGAGNDTLVYGGNSNAYTALLGQTGDDT 495 I G++YL GG G+D GNS A L G G+D Sbjct: 786 IGVAGNNYLNGGDGDDEFQVQGNSLAKNVLFGGKGNDK 823 Score = 72.3 bits (177), Expect = 4e-15 Identities = 64/218 (29%), Positives = 86/218 (39%), Gaps = 12/218 (5%) Query: 110 GGDGNDTLISNTGSDYLYAGAGNDTLIYGGNSNAYTALLGQAGND--TYIIDKVLLTSSS 167 GDG+D + + GS +YAG G+D + Y Y + G + Y + +VL Sbjct: 616 LGDGDDKVFLSAGSANIYAGKGHDVVYYDKTDTGYLTIDGTKATEAGNYTVTRVLGGDVK 675 Query: 168 YIHILDNAAEENTLQLKSVSSGDISLRQSDSLIIISFNDSASTIRFGEGQLSSIVFDDGT 227 + E Q SV + F L S+ GT Sbjct: 676 VLQ------EVVKEQEVSVGKRTEKTQYRSY----EFTHINGKNLTETDNLYSVEELIGT 725 Query: 228 VWDKAQIEANTIGKLLGTDEADALQADAEISTIYGLGGNDTIQGGVQNDYLYGGDGNDTL 287 + G D D ++ + +YG GNDT+ GG +D LYGGDGND L Sbjct: 726 TRADKFFGSKFTDIFHGADGDDLIEGNDGNDRLYGDKGNDTLSGGNGDDQLYGGDGNDKL 785 Query: 288 ISNTGTDYLYGGAGNDTLVYGGNSNAYTALLGQAGNDT 325 I G +YL GG G+D GNS A L G GND Sbjct: 786 IGVAGNNYLNGGDGDDEFQVQGNSLAKNVLFGGKGNDK 823 Score = 57.7 bits (139), Expect = 1e-10 Identities = 29/60 (48%), Positives = 34/60 (56%) Query: 96 NQIVKGSTGNDYLYGGDGNDTLISNTGSDYLYAGAGNDTLIYGGNSNAYTALLGQAGNDT 155 N + G G+D LYGGDGND LI G++YL G G+D GNS A L G GND Sbjct: 764 NDTLSGGNGDDQLYGGDGNDKLIGVAGNNYLNGGDGDDEFQVQGNSLAKNVLFGGKGNDK 823 Score = 51.1 bits (122), Expect = 1e-08 Identities = 43/136 (31%), Positives = 60/136 (44%), Gaps = 10/136 (7%) Query: 96 NQIVKGSTGNDYLYGGDGNDTLISNTGSDYLYAGAGNDTLIYGGNSNAYTALLGQAGNDT 155 + +++G+ GND LYG GNDTL G D LY G GND LI G N Y L G G+D Sbjct: 746 DDLIEGNDGNDRLYGDKGNDTLSGGNGDDQLYGGDGNDKLI-GVAGNNY--LNGGDGDDE 802 Query: 156 YIIDKVLLTSSSYIHILDNAAEENTLQLKSVSSGDISLRQSDSLIIISFNDSASTIRFGE 215 + + +S ++L + L S G L + ++ R+ Sbjct: 803 F----QVQGNSLAKNVLFGGKGNDKL---YGSEGADLLDGGEGDDLLKGGYGNDIYRYLS 855 Query: 216 GQLSSIVFDDGTVWDK 231 G I+ DDG DK Sbjct: 856 GYGHHIIDDDGGKEDK 871 Score = 48.8 bits (116), Expect = 6e-08 Identities = 27/65 (41%), Positives = 33/65 (50%), Gaps = 3/65 (4%) Query: 93 TTSNQIVKGSTGNDYLYGGDGNDTLISNTGSDYLYAGAGNDTLIYGGNSNAYTALLGQAG 152 TT GS D +G DG+D + N G+D LY GNDT + GGN + L G G Sbjct: 725 TTRADKFFGSKFTDIFHGADGDDLIEGNDGNDRLYGDKGNDT-LSGGNGDDQ--LYGGDG 781 Query: 153 NDTYI 157 ND I Sbjct: 782 NDKLI 786 Score = 33.0 bits (75), Expect = 0.005 Identities = 17/77 (22%), Positives = 29/77 (37%), Gaps = 2/77 (2%) Query: 80 IINTASGTYKPTDTTSNQIVKGSTGNDYLYGGDGNDTLI--SNTGSDYLYAGAGNDTLIY 137 ++ G K + ++ G G+D L GG GND S G + G + + Sbjct: 814 VLFGGKGNDKLYGSEGADLLDGGEGDDLLKGGYGNDIYRYLSGYGHHIIDDDGGKEDKLS 873 Query: 138 GGNSNAYTALLGQAGND 154 + + + GND Sbjct: 874 LADIDFRDVAFKREGND 890
>PF05860#haemagglutination activity domain. Length = 117 Score = 66.8 bits (163), Expect = 6e-15 Identities = 19/144 (13%), Positives = 45/144 (31%), Gaps = 29/144 (20%) Query: 74 AGIVADSAANAANRAVIGAGKNSAGTVVPVVNIQTPK-NGISHNIYKQFDVLAEGAVLNN 132 A I D+ + ++ T + + H+ +++F V G N Sbjct: 1 AQITPDTTLPINSNITTEGNT-------RIIERGTQAGSNLFHS-FQEFSVPTSGTAFFN 52 Query: 133 SRQGATTQTVGNVAANPFLATGEARVILNEVNSSAASRFEGNLEVAGQMADVIIANPSGI 192 + + I++ V + S +G + A++ + NP+GI Sbjct: 53 N-------------------PTNIQNIISRVTGGSVSNIDGLIRANAT-ANLFLINPNGI 92 Query: 193 SIKGGGFINANKAIFTTGKPQLNA 216 ++ + + +L Sbjct: 93 IFGQNARLDIGGSFVGSTANRLKF 116
>PF07269#Transport secretion system IV, VirB7 protein Length = 55 Score = 29.6 bits (66), Expect = 0.001 Identities = 18/61 (29%), Positives = 27/61 (44%), Gaps = 7/61 (11%) Query: 1 MKRCLLVLLLGLGLAACNDNDHDDQVSTEKPALAPSLDVGTYIISTETDEELPMAGKYYS 60 MK CLL L + L C N D+ ++ K + P L+VG + +D MA + Sbjct: 1 MKYCLLCLA--IVLTGCQTN---DKPASCKGPIFP-LNVGRW-QPAPSDLHPGMADGQHE 53 Query: 61 G 61 Sbjct: 54 R 54
>HTHTETR#TetR bacterial regulatory protein HTH signature. Length = 215 Score = 50.8 bits (121), Expect = 3e-10 Identities = 11/46 (23%), Positives = 21/46 (45%) Query: 12 SVLHSSRYLFNKYGFHNVGVDRIIEAANIPKATFYNYFHSKERLIE 57 +L + LF++ G + + I +AA + + Y +F K L Sbjct: 15 HILDVALRLFSQQGVSSTSLGEIAKAAGVTRGAIYWHFKDKSDLFS 60
>PF00577#Outer membrane usher protein FimD Length = 878 Score = 758 bits (1959), Expect = 0.0 Identities = 254/852 (29%), Positives = 402/852 (47%), Gaps = 47/852 (5%) Query: 37 ETVASAPVEAEFDSAFLIGDAQ-KVDISRFKYGNPVLPGEYNVDVYVNGQWFGKRRMFFK 95 + E F+ FL D Q D+SRF+ G + PG Y VD+Y+N + R + F Sbjct: 38 AQAPLSSAELYFNPRFLADDPQAVADLSRFENGQELPPGTYRVDIYLNNGYMATRDVTFN 97 Query: 96 ALESNKNAVTCFTGNTLAEYGVKQEILAQHASLQKENSSCYKIEEWVENAFYEFDNSRLR 155 +S + V C T LA G+ ++ + +C + + +A + D + R Sbjct: 98 TGDSEQGIVPCLTRAQLASMGLNTASVSG--MNLLADDACVPLTSMIHDATAQLDVGQQR 155 Query: 156 VDISIPQVALQKNAQGYVDPSLWDRGINAAFLSYNGSAYKTFTQSNDQSETTNAFMGVTA 215 ++++IPQ + A+GY+ P LWD GINA L+YN S Q+ + A++ + + Sbjct: 156 LNLTIPQAFMSNRARGYIPPELWDPGINAGLLNYNFSGNSV--QNRIGGNSHYAYLNLQS 213 Query: 216 GLNLGGWQLRHNGQWQWQDTPAENQSKSSYEETSTYLQRAFPKYRGVLTLGDSFTNGEIF 275 GLN+G W+LR N W + + + + SK+ ++ +T+L+R R LTLGD +T G+IF Sbjct: 214 GLNIGAWRLRDNTTWSYNSSDSSSGSKNKWQHINTWLERDIIPLRSRLTLGDGYTQGDIF 273 Query: 276 DSYGYRGIDFSSDDRMLPNSMLGYAPRIRGNAKTNAKIEVRQQGQLIYQTTVAPGNFEIN 335 D +RG +SDD MLP+S G+AP I G A+ A++ ++Q G IY +TV PG F IN Sbjct: 274 DGINFRGAQLASDDNMLPDSQRGFAPVIHGIARGTAQVTIKQNGYDIYNSTVPPGPFTIN 333 Query: 336 DLYPTGFGGEIEVTVIEANGEIQKFAVPYASVVQMLRPGMNRYSLTVGQFRDQDIDLD-P 394 D+Y G G+++VT+ EA+G Q F VPY+SV + R G RYS+T G++R + + P Sbjct: 334 DIYAAGNSGDLQVTIKEADGSTQIFTVPYSSVPLLQREGHTRYSITAGEYRSGNAQQEKP 393 Query: 395 WVVQGKYQQGINNYLTGYTGIQATENYAAVLLGAAFAT-PIGAIALDVTHSEAEFEKQSS 453 Q G+ T Y G Q + Y A G +GA+++D+T + + S Sbjct: 394 RFFQSTLLHGLPAGWTIYGGTQLADRYRAFNFGIGKNMGALGALSVDMTQANSTLPDDSQ 453 Query: 454 QSGQSFRLSYSKLITPTNTNLTLAAYRYSTENFYKLRDALLIRDFEEKGINT-------- 505 GQS R Y+K + + TN+ L YRYST ++ D R Sbjct: 454 HDGQSVRFLYNKSLNESGTNIQLVGYRYSTSGYFNFADTTYSRMNGYNIETQDGVIQVKP 513 Query: 506 ------YSAGRQRSEFQITLNQGLPEGWGNFYVVGSWVDYWNRSESTKQYQLGYSNNFHG 559 A +R + Q+T+ Q L Y+ GS YW S +Q+Q G + F Sbjct: 514 KFTDYYNLAYNKRGKLQLTVTQQLGR-TSTLYLSGSHQTYWGTSNVDEQFQAGLNTAFED 572 Query: 560 LTYGLSAINRKVEYGSTNQTHDTEYLMTLSFPIDFKKN----------SVNVNVTASEDS 609 + + LS K + D + ++ P S + +++ + Sbjct: 573 INWTLSYSLTKNAWQKGR---DQMLALNVNIPFSHWLRSDSKSQWRHASASYSMSHDLNG 629 Query: 610 RT---VGASGMVG--DRFSYGASMSHQD----YANPSFNVNGRYRTNYTTVGGSYSVADS 660 R G G + + SY + + + YR Y YS +D Sbjct: 630 RMTNLAGVYGTLLEDNNLSYSVQTGYAGGGDGNSGSTGYATLNYRGGYGNANIGYSHSDD 689 Query: 661 YQQAMVSLTGSVVAHSEGILFGPEQGQTMVLVHAPEAAGAKVNNAVGLSVNKAGYAVVPY 720 +Q ++G V+AH+ G+ G T+VLV AP A AKV N G+ + GYAV+PY Sbjct: 690 IKQLYYGVSGGVLAHANGVTLGQPLNDTVVLVKAPGAKDAKVENQTGVRTDWRGYAVLPY 749 Query: 721 VTPYRLNDITLDPQEMSSEVELEETSQRIAPFAGAIAKVDFATKTGYAVYINSKTVDGNS 780 T YR N + LD ++ V+L+ + P GAI + +F + G + + T + Sbjct: 750 ATEYRENRVALDTNTLADNVDLDNAVANVVPTRGAIVRAEFKARVGIKLLMTL-THNNKP 808 Query: 781 LPFAAQVFNQKDEAVGIVAQGSMIYLRTPLAQDRLYVKWGDESNERCSVEYNISNQLQNK 840 LPF A V ++ ++ GIVA +YL ++ VKWG+E N C Y + +++ Sbjct: 809 LPFGAMVTSESSQSSGIVADNGQVYLSGMPLAGKVQVKWGEEENAHCVANYQL--PPESQ 866 Query: 841 QQSMVMTEAVCK 852 QQ + A C+ Sbjct: 867 QQLLTQLSAECR 878
>BICOMPNTOXIN#Staphylococcal bi-component toxin signature. Length = 315 Score = 28.0 bits (62), Expect = 0.013 Identities = 20/62 (32%), Positives = 26/62 (41%), Gaps = 6/62 (9%) Query: 76 KHKNKDEYILWLAGFIERITTGGEAKLPPISKFIPPDFKFNYDEPPKVSSSTRDDGEMII 135 K NKD IL + GFI TT K K + F++N + T D +I Sbjct: 70 KKYNKDALILKMQGFISSRTTYYNYKKTNHVKAMRWPFQYN------IGLKTNDKYVSLI 123 Query: 136 NY 137 NY Sbjct: 124 NY 125
>RTXTOXINA#Gram-negative bacterial RTX toxin determinant A family signature. Length = 1024 Score = 29.5 bits (66), Expect = 0.037 Identities = 28/76 (36%), Positives = 37/76 (48%), Gaps = 9/76 (11%) Query: 325 GGSLLAVMNTASEYGFGAIIASLPG----FAMISHAMSSTFTNPLVNGAVTTTVLAGITG 380 G SLLA A GAI ASL A +S +S+ T LV GA + ++ +TG Sbjct: 350 GDSLLA----AFHKETGAIDASLTTISTVLASVSSGISAAATTSLV-GAPVSALVGAVTG 404 Query: 381 SASGGMSIALSAMAEH 396 SG + + AM EH Sbjct: 405 IISGILEASKQAMFEH 420
>TCRTETB#Tetracycline resistance protein TetB signature. Length = 458 Score = 62.6 bits (152), Expect = 6e-13 Identities = 44/178 (24%), Positives = 82/178 (46%), Gaps = 3/178 (1%) Query: 2 NAIHRPPLWLLTLLIMFPQLVETIYSPALTYISHSFAVTSKQAAQTLSVYFIAFAIGVGL 61 N H L L +L F L E + + +L I++ F + + + F+IG + Sbjct: 9 NLRHNQILIWLCILSFFSVLNEMVLNVSLPDIANDFNKPPASTNWVNTAFMLTFSIGTAV 68 Query: 62 WGWLSDQIGRRYAMMLGLICYGAGTLLA-ITTVNFKILLFARMISAFGAAAGSVVVQTML 120 +G LSDQ+G + ++ G+I G+++ + F +L+ AR I GAAA +V ++ Sbjct: 69 YGKLSDQLGIKRLLLFGIIINCFGSVIGFVGHSFFSLLIMARFIQGAGAAAFPALVMVVV 128 Query: 121 RDSYKSTKLASVFTLMGAALAISPVFGLVSGGWLVS--HWGYMGVFIALFLLAILLLI 176 F L+G+ +A+ G GG + HW Y+ + + ++ + L+ Sbjct: 129 ARYIPKENRGKAFGLIGSIVAMGEGVGPAIGGMIAHYIHWSYLLLIPMITIITVPFLM 186
>PF07520#Virulence protein SrfB Length = 1041 Score = 26.1 bits (57), Expect = 0.034 Identities = 11/59 (18%), Positives = 21/59 (35%), Gaps = 10/59 (16%) Query: 38 GGGLVKVTMTGRYLVKRIEINPELLQDEP----------DMIEDLIAAAVNDAVRQAEV 86 GGG + +T ++PE E +I ++ + D++ QA Sbjct: 603 GGGTTDLMVTTYRGEDNRVLHPEQTFREGFRVAGDDLVHRVISAIVLPRLQDSIAQAGG 661
>DNABINDINGHU#Prokaryotic integration host factor signature. Length = 91 Score = 121 bits (305), Expect = 7e-40 Identities = 49/88 (55%), Positives = 68/88 (77%) Query: 2 NKSELIDAIAEKGGVSKTDAGKALDATIASITEALKKGDTVTLVGFGTFSVKERAARTGR 61 NK +LI +AE ++K D+ A+DA ++++ L KG+ V L+GFG F V+ERAAR GR Sbjct: 3 NKQDLIAKVAEATELTKKDSAAAVDAVFSAVSSYLAKGEKVQLIGFGNFEVRERAARKGR 62 Query: 62 NPKTGEELQIKATKVPSFKAGKGLKDSV 89 NP+TGEE++IKA+KVP+FKAGK LKD+V Sbjct: 63 NPQTGEEIKIKASKVPAFKAGKALKDAV 90
>TYPE3IMSPROT#Type III secretion system inner membrane S protein family signature. Length = 354 Score = 26.3 bits (58), Expect = 0.031 Identities = 14/88 (15%), Positives = 35/88 (39%), Gaps = 1/88 (1%) Query: 4 ILIALLIVVFGYSLALVLQNPTELSVDLLFTQV-PAMRLGLLLLLTLVLGTVVGLLLGVQ 62 + L +V+ + ++++ + L + L +L L++ VG ++ Sbjct: 141 LKSILKVVLLSILIWIIIKGNLVTLLQLPTCGIECITPLLGQILRQLMVICTVGFVVISI 200 Query: 63 VFRVFQKGWEIKRLRKDIDHLRKEQIQS 90 F+ IK L+ D +++E + Sbjct: 201 ADYAFEYYQYIKELKMSKDEIKREYKEM 228
>DNABINDINGHU#Prokaryotic integration host factor signature. Length = 91 Score = 105 bits (263), Expect = 2e-33 Identities = 34/89 (38%), Positives = 51/89 (57%), Gaps = 1/89 (1%) Query: 7 NKSDLIERIALKNPHLAEPLVEEAVKIMIDQMIEALSTDNRIEIRGFGSFALHHRDPRVG 66 NK DLI ++A L + AV + + L+ ++++ GFG+F + R R G Sbjct: 3 NKQDLIAKVAEAT-ELTKKDSAAAVDAVFSAVSSYLAKGEKVQLIGFGNFEVRERAARKG 61 Query: 67 RNPKTGRSVEVAAKAVPHFKPGKALRDAV 95 RNP+TG +++ A VP FK GKAL+DAV Sbjct: 62 RNPQTGEEIKIKASKVPAFKAGKALKDAV 90
>PF00577#Outer membrane usher protein FimD Length = 878 Score = 711 bits (1836), Expect = 0.0 Identities = 239/873 (27%), Positives = 390/873 (44%), Gaps = 53/873 (6%) Query: 11 LKSPFTCYVASSIALFMPLAAYAQNNVDVSGFSKAEFDSNFLVGNAQ-KIDIGRFKYGNP 69 + F + + A + + F+ FL + Q D+ RF+ G Sbjct: 22 RLAGFFVRLFVACAFAAQAPLSSA---------ELYFNPRFLADDPQAVADLSRFENGQE 72 Query: 70 ILAGEYSLDVYINDQWFGKRRMRFNASSPNVNAETCFTEAMLLEYGVKADVLSQHSHTSS 129 + G Y +D+Y+N+ + R + FN C T A L G+ +S + + Sbjct: 73 LPPGTYRVDIYLNNGYMATRDVTFNTGDSEQGIVPCLTRAQLASMGLNTASVSGMNLLAD 132 Query: 130 LSCDALGHWIDNAFYLFDSSRLRIDISIPQVTLEKNAQGYIDPHLWDRGINAAFLTYNAT 189 +C L I +A D + R++++IPQ + A+GYI P LWD GINA L YN + Sbjct: 133 DACVPLTSMIHDATAQLDVGQQRLNLTIPQAFMSNRARGYIPPELWDPGINAGLLNYNFS 192 Query: 190 AYRIVNEQH-ESVYAFMGTNLGANLASWQFRHNGQWKWQDHTDFQSDNSSYTSTNTYIQK 248 + N S YA++ G N+ +W+ R N W + + + NT++++ Sbjct: 193 GNSVQNRIGGNSHYAYLNLQSGLNIGAWRLRDNTTWSYNSSDSSSGSKNKWQHINTWLER 252 Query: 249 AFPKIHGVVTLGDYFTNSDFIDSLPYRGVNISSDDRMLPNSMLGYAPRVRGYAKTNAKVE 308 + +TLGD +T D D + +RG ++SDD MLP+S G+AP + G A+ A+V Sbjct: 253 DIIPLRSRLTLGDGYTQGDIFDGINFRGAQLASDDNMLPDSQRGFAPVIHGIARGTAQVT 312 Query: 309 VRQQGNLIYQTTVPPGNFEINDLYPTGFGGELQVSVIESNGVIQKFAIPYASVVEMLRPQ 368 ++Q G IY +TVPPG F IND+Y G G+LQV++ E++G Q F +PY+SV + R Sbjct: 313 IKQNGYDIYNSTVPPGPFTINDIYAAGNSGDLQVTIKEADGSTQIFTVPYSSVPLLQREG 372 Query: 369 MSRYSFTLGQFR-DSNLGLNPWLIQGKYQRGINNYLTTYTALQATQQYLSLLLGTAFST- 426 +RYS T G++R + P Q G+ T Y Q +Y + G + Sbjct: 373 HTRYSITAGEYRSGNAQQEKPRFFQSTLLHGLPAGWTIYGGTQLADRYRAFNFGIGKNMG 432 Query: 427 PIGAISFDATQSKTEFDHQPTMTGQSYRLSYSKLFSPTNTSLTLATYRYSTENYLKLRDA 486 +GA+S D TQ+ + GQS R Y+K + + T++ L YRYST Y D Sbjct: 433 ALGALSVDMTQANSTLPDDSQHDGQSVRFLYNKSLNESGTNIQLVGYRYSTSGYFNFADT 492 Query: 487 ILIQDLQKQNIDSFSVG--------------KQKSEFQITLNQVLPKQWGNFYLVGSWIN 532 + V ++ + Q+T+ Q L + YL GS Sbjct: 493 TYSRMNGYNIETQDGVIQVKPKFTDYYNLAYNKRGKLQLTVTQQLGR-TSTLYLSGSHQT 551 Query: 533 YWNQPKTNKQFQLGYSNQFKDLTYSLSAMSSEIEEDGARTGQDTQYLASFSFPLDFKKNS 592 YW ++QFQ G + F+D+ ++LS + ++ + G+D + + P S Sbjct: 552 YWGTSNVDEQFQAGLNTAFEDINWTLSYSLT---KNAWQKGRDQMLALNVNIPFSHWLRS 608 Query: 593 LTFNSVI-------------GDNSQILSFSG--FTGNRLNYGASISNQDHD----QTNLN 633 + + G + + G N L+Y + Sbjct: 609 DSKSQWRHASASYSMSHDLNGRMTNLAGVYGTLLEDNNLSYSVQTGYAGGGDGNSGSTGY 668 Query: 634 INGTYKTNYTTLGASFSHANSYQQEMLSFSGNVVAHSQGILFGPDQAQTMVLVYAPDATG 693 Y+ Y +SH++ +Q SG V+AH+ G+ G T+VLV AP A Sbjct: 669 ATLNYRGGYGNANIGYSHSDDIKQLYYGVSGGVLAHANGVTLGQPLNDTVVLVKAPGAKD 728 Query: 694 AQVGNTPGLSINKNGYAVIPYVTPYRMNDISLDPQDISTQVELAESSLRIAPYAGSITKV 753 A+V N G+ + GYAV+PY T YR N ++LD ++ V+L + + P G+I + Sbjct: 729 AKVENQTGVRTDWRGYAVLPYATEYRENRVALDTNTLADNVDLDNAVANVVPTRGAIVRA 788 Query: 754 QFSTKKGYALFISTTTLDGSHLPFAAQVYNQNNEVIGIVAQGSRIYLRTPLTHDRLYVKW 813 +F + G L + T T + LPF A V +++++ GIVA ++YL ++ VKW Sbjct: 789 EFKARVGIKLLM-TLTHNNKPLPFGAMVTSESSQSSGIVADNGQVYLSGMPLAGKVQVKW 847 Query: 814 GNTSTEKCEIEYDIADQIKHNNQPIIMTKAVCK 846 G C Y + + + Q + A C+ Sbjct: 848 GEEENAHCVANYQLPPESQ--QQLLTQLSAECR 878
>DHBDHDRGNASE#2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase signature. Length = 261 Score = 106 bits (265), Expect = 2e-29 Identities = 75/255 (29%), Positives = 119/255 (46%), Gaps = 15/255 (5%) Query: 44 LKDKVAVISGGDSGIGRSVAVLFAREGADIAILYLEEDKDAEITKQLVEREGQHCLLLKG 103 ++ K+A I+G GIG +VA A +GA IA + +K E ++ E +H Sbjct: 6 IEGKIAFITGAAQGIGEAVARTLASQGAHIAAVDYNPEK-LEKVVSSLKAEARHAEAFPA 64 Query: 104 DISDPDVAKLDIDKVLQHYGKINILVNNAGVQYQQKEIESISNEQLEKTFKTNIFPMFYL 163 D+ D ++ + G I+ILVN AGV + I S+S+E+ E TF N +F Sbjct: 65 DVRDSAAIDEITARIEREMGPIDILVNVAGV-LRPGLIHSLSDEEWEATFSVNSTGVFNA 123 Query: 164 TKEAIPYM--EEGDSIINTTSITSYQGHDELIDYASTKGAITTFTRSLSNNLMKQKKGIR 221 ++ YM SI+ S + + YAS+K A FT+ L L + IR Sbjct: 124 SRSVSKYMMDRRSGSIVTVGSNPAGVPRTSMAAYASSKAAAVMFTKCLGLELAEY--NIR 181 Query: 222 VNGVAPGPI-----WTPLIPSSFDAETVKEFGKD----TPMGRMGQPSEVAPAYLFLASD 272 N V+PG W+ + + +K + P+ ++ +PS++A A LFL S Sbjct: 182 CNIVSPGSTETDMQWSLWADENGAEQVIKGSLETFKTGIPLKKLAKPSDIADAVLFLVSG 241 Query: 273 DASYITGQVIHVNGG 287 A +IT + V+GG Sbjct: 242 QAGHITMHNLCVDGG 256
>HTHTETR#TetR bacterial regulatory protein HTH signature. Length = 215 Score = 70.0 bits (171), Expect = 4e-17 Identities = 30/168 (17%), Positives = 65/168 (38%), Gaps = 11/168 (6%) Query: 9 MQERMEQNRKSILSSARKIISEGGFKDAQIQTIAEQAGVSSGLVYRYFDNKSQVLIEVLS 68 ++ ++ R+ IL A ++ S+ G + IA+ AGV+ G +Y +F +KS + E+ Sbjct: 5 TKQEAQETRQHILDVALRLFSQQGVSSTSLGEIAKAAGVTRGAIYWHFKDKSDLFSEIWE 64 Query: 69 EAINTELLVIDSITESELSAKQKLHKAVATFVKRALNSPQLAYSLMFEPVDSTVEH--ER 126 + + + + + + V + + + L+ E + E E Sbjct: 65 LSESNIGELELEYQAKFPGDPLSVLREILIHVLESTVTEE-RRRLLMEIIFHKCEFVGEM 123 Query: 127 FRVKQLIKQS-------IKKILADGNASGEFVLD-DLNTAALCVVGAM 166 V+Q + I++ L + D AA+ + G + Sbjct: 124 AVVQQAQRNLCLESYDRIEQTLKHCIEAKMLPADLMTRRAAIIMRGYI 171
>PHPHTRNFRASE#Phosphoenolpyruvate-protein phosphotransferase signature. Length = 572 Score = 28.6 bits (64), Expect = 0.026 Identities = 27/149 (18%), Positives = 57/149 (38%), Gaps = 29/149 (19%) Query: 105 RVHGIAFGGGMGLASACDICIASTDAKFATSEVRLGLAPSTISPY---VIRAIGARQASR 161 ++ GIA G+ +A A F E + + ++I+ + + A + S+ Sbjct: 4 KITGIAASSGVAIAKA-----------FIHLEPNVDIEKTSITDVSTEIEKLTAALEKSK 52 Query: 162 YFLTAERISAREAKHIGLAH--------EVADAEDLDKKVQEIVDALLLGGPHAQAASKQ 213 L I + +G V D +L ++ ++ +A+ A K+ Sbjct: 53 EEL--RAIKDQTEASMGADKAEIFAAHLLVLDDPELVDGIKGKIEN---EQMNAEYALKE 107 Query: 214 LIQMVSNQ--TMSNELLQQTAHHIAQVRQ 240 + M + +M NE +++ A I V + Sbjct: 108 VSDMFVSMFESMDNEYMKERAADIRDVSK 136
>RTXTOXIND#Gram-negative bacterial RTX secretion protein D signature. Length = 478 Score = 29.4 bits (66), Expect = 0.045 Identities = 12/45 (26%), Positives = 22/45 (48%) Query: 590 LKAPMPGVVTQVLVSANHSVKKDDILMTLEAMKMEYTIRAPKDGL 634 +K +V +++V SV+K D+L+ L A+ E + L Sbjct: 99 IKPIENSIVKEIIVKEGESVRKGDVLLKLTALGAEADTLKTQSSL 143
>OMPADOMAIN#OMPA domain signature. Length = 346 Score = 96.9 bits (241), Expect = 1e-25 Identities = 42/112 (37%), Positives = 59/112 (52%), Gaps = 11/112 (9%) Query: 154 FESGSAVLTDAGQKILDEMAVALNKVGGK--KVKIVGHTDSSGDATKNLKLSQDRALAVK 211 F A L GQ LD++ L+ + K V ++G+TD G N LS+ RA +V Sbjct: 223 FNFNKATLKPEGQAALDQLYSQLSNLDPKDGSVVVLGYTDRIGSDAYNQGLSERRAQSVV 282 Query: 212 NYLISKSIPADHLSAEGLGSSKPVADNTSPEGRKK---------NRRIEFTV 254 +YLISK IPAD +SA G+G S PV NT +++ +RR+E V Sbjct: 283 DYLISKGIPADKISARGMGESNPVTGNTCDNVKQRAALIDCLAPDRRVEIEV 334
>FRAGILYSIN#Fragilysin metallopeptidase (M10C) enterotoxin signature. Length = 405 Score = 28.9 bits (64), Expect = 0.018 Identities = 16/50 (32%), Positives = 23/50 (46%), Gaps = 7/50 (14%) Query: 48 LTSSPILLMAGKAKDGITFIGEIDKYPLVGQFTTARFEENDELIAVISEK 97 L + + L G+ KD +FI L +F RF N E I+ I+ K Sbjct: 93 LDNENVRLFNGRDKDSTSFI-------LGDEFAVLRFYRNGESISYIAYK 135
>OMADHESIN#Yersinia outer membrane adhesin signature. Length = 455 Score = 31.8 bits (71), Expect = 0.014 Identities = 45/178 (25%), Positives = 66/178 (37%), Gaps = 17/178 (9%) Query: 307 QTMTLIDNMKQNLVANSIQAKFKIIDSNEQQRKKITEPYLQAAIQR----------AERM 356 Q L K N Q K +I + E K+ E A A Sbjct: 195 QLTHLAAGTKDTDAVNVAQLKKEIEKTQENTNKRSAELLANANAYADNKSSSVLGIANNY 254 Query: 357 GDKKGLENLKNFEKNAPAKAAAELEKQRAEAVKQATVDGDHAWKKYQAQLDLNGLEKFRK 416 D K E L+N K A A++ L +A + A + A +++ + LE + Sbjct: 255 TDSKSAETLENARKEAFAQSKDVLNMAKAHSNSVARTTLETA-EEHANSVARTTLETAEE 313 Query: 417 DVDKKSEESYAAAARYVDDHYNWLVSSNLLKGL-FYFDQSEELKQGKTPKESNGFIFH 473 +KKS E+ A+A Y D SS+ LK Y D + K +ESN + H Sbjct: 314 HANKKSAEALASANVYADSK-----SSHTLKTANSYTDVTVSNSTKKAIRESNQYTDH 366
>HTHTETR#TetR bacterial regulatory protein HTH signature. Length = 215 Score = 53.9 bits (129), Expect = 2e-11 Identities = 36/186 (19%), Positives = 66/186 (35%), Gaps = 15/186 (8%) Query: 12 RVLHVAKDLFNQDGFHKVGVDRIIAEAKIPKATFYNDFHSKARLIEMCLTFQKDALKVKV 71 +L VA LF+Q G + I A + + Y F K+ L + + + Sbjct: 15 HILDVALRLFSQQGVSSTSLGEIAKAAGVTRGAIYWHFKDKSDLFSEIWELSESNIGE-L 73 Query: 72 FSILKSYREEMVLDKLKQIYL--LHTDLNGFYRLLFKAIFEIEKLYPKAYSVVIEYRTWL 129 ++ L L++I + L + + R L I + + +VV + + L Sbjct: 74 ELEYQAKFPGDPLSVLREILIHVLESTVTEERRRLLMEIIFHKCEFVGEMAVVQQAQRNL 133 Query: 130 INEVYKLL-----LTVKTTASMKD------AHMFLFVIDGAMVQ-LLSKNSVDERDKLLE 177 E Y + ++ D A + I G M L + S D + + + Sbjct: 134 CLESYDRIEQTLKHCIEAKMLPADLMTRRAAIIMRGYISGLMENWLFAPQSFDLKKEARD 193 Query: 178 YFFIML 183 Y I+L Sbjct: 194 YVAILL 199
>TYPE3IMSPROT#Type III secretion system inner membrane S protein family signature. Length = 354 Score = 25.1 bits (55), Expect = 0.022 Identities = 5/34 (14%), Positives = 18/34 (52%) Query: 3 IIKTILKILKWLIVLFLMFVILLGMIEFIANKFF 36 I + +IL+ L+V+ + +++ + ++ + Sbjct: 176 ITPLLGQILRQLMVICTVGFVVISIADYAFEYYQ 209
>RTXTOXIND#Gram-negative bacterial RTX secretion protein D signature. Length = 478 Score = 31.3 bits (71), Expect = 0.010 Identities = 13/49 (26%), Positives = 23/49 (46%) Query: 509 APINGVISAWKVENGEQVTEGQVVAIMEAMKMEVQVLAHRSGVIQISAE 557 N ++ V+ GE V +G V+ + A+ E L +S ++Q E Sbjct: 101 PIENSIVKEIIVKEGESVRKGDVLLKLTALGAEADTLKTQSSLLQARLE 149
>HTHTETR#TetR bacterial regulatory protein HTH signature. Length = 215 Score = 49.2 bits (117), Expect = 1e-09 Identities = 13/70 (18%), Positives = 26/70 (37%), Gaps = 1/70 (1%) Query: 7 PTRAMQVLNTSIDLFHHHGFHTVGIDRIVKESKIPKATFYNYFHSKERFVEICLIVQKER 66 TR +L+ ++ LF G + + I K + + + Y +F K + + Sbjct: 11 ETRQ-HILDVALRLFSQQGVSSTSLGEIAKAAGVTRGAIYWHFKDKSDLFSEIWELSESN 69 Query: 67 LKEKVLSIAE 76 + E L Sbjct: 70 IGELELEYQA 79
>HTHTETR#TetR bacterial regulatory protein HTH signature. Length = 215 Score = 46.9 bits (111), Expect = 7e-09 Identities = 13/92 (14%), Positives = 30/92 (32%), Gaps = 1/92 (1%) Query: 7 PTRAIQVINTSIYLFHHHGFHTVGVDRIVKECQIPKATFYNYFHSKERFIEICLIVQKER 66 TR +++ ++ LF G + + I K + + Y +F K + + Sbjct: 11 ETRQ-HILDVALRLFSQQGVSSTSLGEIAKAAGVTRGAIYWHFKDKSDLFSEIWELSESN 69 Query: 67 LKEKVVSIAEYDRGTSVKDKLKALYLLHTDLE 98 + E + G + + L + Sbjct: 70 IGELELEYQAKFPGDPLSVLREILIHVLESTV 101
>TCRTETB#Tetracycline resistance protein TetB signature. Length = 458 Score = 35.2 bits (81), Expect = 4e-04 Identities = 35/151 (23%), Positives = 62/151 (41%), Gaps = 14/151 (9%) Query: 257 NTLIASSLLIFSGIGSLVGNISARWLHIFFSVKFLMLFSIILMIIGSIIMSFARGPIWIT 316 N + + +L FS ++ G +S + +K L+LF II+ GS+I Sbjct: 52 NWVNTAFMLTFSIGTAVYGKLSDQ-----LGIKRLLLFGIIINCFGSVIGFVGHSFF--- 103 Query: 317 SILISIGYFLWGLCLGLFNIYSATYRQKVVPPEAMGKLVGAARTLIYGAMPLGSLSGGLI 376 S+LI + F+ G F + +P E GK G +++ +G GG+I Sbjct: 104 SLLI-MARFIQGAGAAAFPALVMVVVARYIPKENRGKAFGLIGSIVAMGEGVGPAIGGMI 162 Query: 377 VDFLGSRYVFLFNCLINLISLVILFFSLRKV 407 ++ Y+ L + +I L K+ Sbjct: 163 AHYIHWSYLLLI-----PMITIITVPFLMKL 188
>LPSBIOSNTHSS#Lipopolysaccharide core biosynthesis protein signature. Length = 166 Score = 27.1 bits (60), Expect = 0.022 Identities = 8/37 (21%), Positives = 17/37 (45%) Query: 115 FIPNDCWILTSENIVKIIADREGPKKELLPDIIQAAV 151 + + S ++VK +A G + +P + AA+ Sbjct: 116 LTTSTEYSFLSSSLVKEVARFGGNVEHFVPSHVAAAL 152
>SECBCHAPRONE#Bacterial protein-transport SecB chaperone protein signature. Length = 170 Score = 28.7 bits (64), Expect = 0.005 Identities = 9/45 (20%), Positives = 21/45 (46%) Query: 80 FRFEVIDEEEVEQKLNNCIPSICYPYMRSFLNTLFANSGVEPVYL 124 F ++E ++ L + P++ +PY R +++L + L Sbjct: 95 FTISGLEEMQMAHCLTSQCPNMLFPYARELVSSLVNRGTFPALNL 139
>HTHFIS#FIS bacterial regulatory protein HTH signature. Length = 484 Score = 408 bits (1050), Expect = e-140 Identities = 137/372 (36%), Positives = 209/372 (56%), Gaps = 26/372 (6%) Query: 210 PEPMEKELIALQAELFELKKSIYSDSEADYQLFSSVGKSASYKQVCALLTKAAGSKVSIL 269 P + + + + L E K+ + VG+SA+ +++ +L + + ++++ Sbjct: 105 PFDLTELIGIIGRALAEPKRRPSKLEDDSQDGMPLVGRSAAMQEIYRVLARLMQTDLTLM 164 Query: 270 LQGETGVGKEAFARGVHANSQRKDQPFIAVNCAAIPPELIESELFGVEKGAYTGAHQSRL 329 + GE+G GKE AR +H +R++ PF+A+N AAIP +LIESELFG EKGA+TGA Sbjct: 165 ITGESGTGKELVARALHDYGKRRNGPFVAINMAAIPRDLIESELFGHEKGAFTGAQTRST 224 Query: 330 GKFERANGGTIFLDEVIELSPRAQAALLRILQEGEFERVGDSQTRILDVRVITATNEDLE 389 G+FE+A GGT+FLDE+ ++ AQ LLR+LQ+GE+ VG DVR++ ATN+DL+ Sbjct: 225 GRFEQAEGGTLFLDEIGDMPMDAQTRLLRVLQQGEYTTVGGRTPIRSDVRIVAATNKDLK 284 Query: 390 QAVKTGRFRADLYYRLNIFPVQIPPLRERREDIPLLVEHFLRRFEKMYGKTIQGVSEKTK 449 Q++ G FR DLYYRLN+ P+++PPLR+R EDIP LV HF+++ EK G ++ ++ Sbjct: 285 QSINQGLFREDLYYRLNVVPLRLPPLRDRAEDIPDLVRHFVQQAEKE-GLDVKRFDQEAL 343 Query: 450 VFMQQYEWPGNIRELENLLERAVLLTDDQQL------IKLNAIFPQIKHDPEQA------ 497 M+ + WPGN+RELENL+ R L + +L + P + A Sbjct: 344 ELMKAHPWPGNVRELENLVRRLTALYPQDVITREIIENELRSEIPDSPIEKAAARSGSLS 403 Query: 498 --VAVKTDFEQLLQAEFN-----------LEEHEKQLILTALKKANHNVSEAARLLGLTR 544 AV+ + Q + + L E E LIL AL N +AA LLGL R Sbjct: 404 ISQAVEENMRQYFASFGDALPPSGLYDRVLAEMEYPLILAALTATRGNQIKAADLLGLNR 463 Query: 545 AALDYRIKKFQL 556 L +I++ + Sbjct: 464 NTLRKKIRELGV 475
>PF05932#Tir chaperone protein (CesT) Length = 127 Score = 29.0 bits (65), Expect = 0.017 Identities = 9/52 (17%), Positives = 15/52 (28%) Query: 253 AGSWGKQGGGSYGFENGHMLLWTQWANPEDRPNFPKADEYTEKYGEAMSKWM 304 A + G G + L + P ++ + P E M W Sbjct: 72 ALNPLLNAGPGLGLDEKSGLYHAYQSIPREKLSVPTLKREMAGLLEWMRGWR 123
>CARBMTKINASE#Bacterial carbamate kinase signature. Length = 314 Score = 35.6 bits (82), Expect = 3e-04 Identities = 27/116 (23%), Positives = 47/116 (40%), Gaps = 27/116 (23%) Query: 125 LDAGRVIVVAGFQGFDANGNITTLGRGGS----------DTSGVALAAALKADECQIYTD 174 ++ G +++ +G G + + G D +G LA + AD I TD Sbjct: 183 VERGVIVIASG------GGGVPVILEDGEIKGVEAVIDKDLAGEKLAEEVNADIFMILTD 236 Query: 175 VDGVYTTDPRVAPKAKKIDRISFEEMLEMA--------SLGSKVLQ-IRSVEFAGK 221 V+G K + + + EE+ + S+G KVL IR +E+ G+ Sbjct: 237 VNGAALYYGT--EKEQWLREVKVEELRKYYEEGHFKAGSMGPKVLAAIRFIEWGGE 290
>HTHTETR#TetR bacterial regulatory protein HTH signature. Length = 215 Score = 62.0 bits (150), Expect = 5e-14 Identities = 22/119 (18%), Positives = 49/119 (41%) Query: 5 KPRQTRAKVTVDTIIEAGFIAVALHGPSGTTTRHIAEIAGVSVGSLYEYFKNKEEIYDAM 64 + + A+ T I++ + G S T+ IA+ AGV+ G++Y +FK+K +++ + Sbjct: 3 RKTKQEAQETRQHILDVALRLFSQQGVSSTSLGEIAKAAGVTRGAIYWHFKDKSDLFSEI 62 Query: 65 NHFFVREILDMITELTPTILQLELEPVIEMIFYTFSDLLKKNNDRYLTVLRYAGELQYD 123 I ++ E L + E++ + + + R L + + Sbjct: 63 WELSESNIGELELEYQAKFPGDPLSVLREILIHVLESTVTEERRRLLMEIIFHKCEFVG 121
>DHBDHDRGNASE#2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase signature. Length = 261 Score = 94.0 bits (233), Expect = 6e-25 Identities = 53/178 (29%), Positives = 85/178 (47%), Gaps = 1/178 (0%) Query: 17 AVVTGAGSGIGRSFALELAKRGGSVVCADINLEAAEETVKLLEQEGAKAFAMRCDVGNAE 76 A +TGA GIG + A LA +G + D N E E+ V L+ E A A DV ++ Sbjct: 11 AFITGAAQGIGEAVARTLASQGAHIAAVDYNPEKLEKVVSSLKAEARHAEAFPADVRDSA 70 Query: 77 QVNHLAETAEILLGHPVTLVINNAGVGLGGKFDELSLEDWNWVMNINLWGVIHGCHAFVP 136 ++ + E +G P+ +++N AGV G LS E+W ++N GV + + Sbjct: 71 AIDEITARIEREMG-PIDILVNVAGVLRPGLIHSLSDEEWEATFSVNSTGVFNASRSVSK 129 Query: 137 KFKKLGYGAIINVASAASYTAAPEMTAYNVTKAGVRALSETLSAELHKFNIKVNVLCP 194 G+I+ V S + M AY +KA ++ L EL ++NI+ N++ P Sbjct: 130 YMMDRRSGSIVTVGSNPAGVPRTSMAAYASSKAAAVMFTKCLGLELAEYNIRCNIVSP 187
>TCRTETA#Tetracycline resistance protein signature. Length = 399 Score = 56.4 bits (136), Expect = 8e-11 Identities = 57/331 (17%), Positives = 116/331 (35%), Gaps = 12/331 (3%) Query: 65 AILGGRFADIVGRKKILIFSILLFGIMSLLTAYAANFSLLLLIRFCTGLGMGGALPMMIT 124 A + G +D GR+ +L+ S+ + + A A +L + R G+ G + Sbjct: 60 APVLGALSDRFGRRPVLLVSLAGAAVDYAIMATAPFLWVLYIGRIVAGI-TGATGAVAGA 118 Query: 125 LASEAVPDKYKGTAVSIMYSGIPFGGLLTSVVAMSLAGDAEWRHIFYIGGIAPILLIPLI 184 ++ + M S G++ V L G F+ L Sbjct: 119 YIADITDGDERARHFGFM-SACFGFGMVAGPVLGGLMGGFSPHAPFFAAAALNGLNFLTG 177 Query: 185 MRFLPESNDYLQRKGQAQKTTPFLEVLFAKERRMSTIQLWVSFFCTLVVLYFLLNWLPLL 244 LPES+ +R + + P +A+ + + V F LV W ++ Sbjct: 178 CFLLPESHKGERRPLRREALNPLASFRWARGMTVVAALMAVFFIMQLVGQVPAALW--VI 235 Query: 245 MGAQGLSKLQANYVQMGYNVGGILGSILMGVLLDKLRMSF-VIKLIYLGILFSLCCLAIS 303 G A + + GIL S+ ++ + + + LG++ + Sbjct: 236 FGEDRFH-WDATTIGISLAAFGILHSLAQAMITGPVAARLGERRALMLGMIADGTGYILL 294 Query: 304 PTVALLALSAVGCGLFIVGG--QSALYGLAAMYYPTEMRGTGVGSAVAIGRIGSFAGPLM 361 ++ L GG AL + + E +G GS A+ + S GPL+ Sbjct: 295 AFATRGWMAFPIMVLLASGGIGMPALQAMLSRQVDEERQGQLQGSLAALTSLTSIVGPLL 354 Query: 362 AGFLLSLGQSS----TIVIGSSIPVILIAAI 388 + + ++ + G+++ ++ + A+ Sbjct: 355 FTAIYAASITTWNGWAWIAGAALYLLCLPAL 385
>PF07520#Virulence protein SrfB Length = 1041 Score = 27.6 bits (61), Expect = 0.018 Identities = 9/36 (25%), Positives = 18/36 (50%), Gaps = 1/36 (2%) Query: 42 NPRGTVE-GGMICAMLDDVMGLFAYLANDRKPATTI 76 +P+ TV GGM+ A+ ++ + F + +T Sbjct: 858 DPKSTVAVGGMLIALSENRIPNFKVTTGAFQMKSTA 893
>PHAGEIV#Gene IV protein signature. Length = 426 Score = 29.1 bits (65), Expect = 0.003 Identities = 13/46 (28%), Positives = 21/46 (45%) Query: 34 AAGTTAGTVGGAATGASVGAAIGTIAGPLGVIVGGTVGTFVGAISA 79 AAG+ GTV G + + + + G G+ G +G V A+ Sbjct: 218 AAGSQRGTVAGGVNTDRLTSVLSSAGGSFGIFNGDVLGLSVRALKT 263
>CABNDNGRPT#NodO calcium binding signature. Length = 479 Score = 26.9 bits (59), Expect = 0.031 Identities = 16/88 (18%), Positives = 25/88 (28%), Gaps = 6/88 (6%) Query: 1 MSLKKFLLLPISLAFSAAGCAGIGPNATYYMGTTSVNYNPSYNTYDVKLN------NHII 54 ++ + P G++ NYN S H I Sbjct: 131 ITFGNYTRDASGNLDYGTQAYAYYPGNYQGAGSSWYNYNQSNIRNPGSEEYGRQTFTHEI 190 Query: 55 GGALGSMNTSPVILGLQNVTWKDAKTGE 82 G ALG + G + ++ DA E Sbjct: 191 GHALGLAHPGEYNAGEGDPSYNDAVYAE 218
>FLGHOOKAP1#Flagellar hook-associated protein signature. Length = 546 Score = 31.5 bits (71), Expect = 0.016 Identities = 20/110 (18%), Positives = 35/110 (31%), Gaps = 6/110 (5%) Query: 721 INALDSVTVGSGQSINVSTDEHLILNAKKKVSLFAGEEDLKIYAAKGKFDLQSQDNVLDV 780 N L + + ++ N N FA + + K K D+ V D Sbjct: 294 RNTLGQLALAFAEAFNTQHKAGFDANGDAGEDFFAIGKPAVLQNTKNKGDVAIGATVTDA 353 Query: 781 SARLDV--KITSSEGKVEIHSP----TEIVFKAKDSALKINGDGVTVITP 824 SA L KI+ + ++ T V + + +G +T Sbjct: 354 SAVLATDYKISFDNNQWQVTRLASNTTFTVTPDANGKVAFDGLELTFTGT 403
>HTHTETR#TetR bacterial regulatory protein HTH signature. Length = 215 Score = 50.8 bits (121), Expect = 3e-10 Identities = 30/186 (16%), Positives = 59/186 (31%), Gaps = 21/186 (11%) Query: 12 SVLHTSRYLFNNYGFHNVWVDRIIESAKIPKATFYNYFHSKERLIQMSLTFQKDGLKHEV 71 +L + LF+ G + + I ++A + + Y +F K L + + E+ Sbjct: 15 HILDVALRLFSQQGVSSTSLGEIAKAAGVTRGAIYWHFKDKSDLFSEIWELSESNI-GEL 73 Query: 72 LSIIHDQKELTLVEKLRKLYFLHADLDGLYHLP----FKAIFEIAKTHPKVYQVVVEYRN 127 + + LR++ L L+ I VV + + Sbjct: 74 ELEYQAKFPGDPLSVLREI--LIHVLESTVTEERRRLLMEIIFHKCEFVGEMAVVQQAQR 131 Query: 128 WFINEIYNLL------------LTTNTNASKQDAHMFLFVIDGAMVQ-LLDPNKPDEREK 174 E Y+ + L + + A + I G M L P D +++ Sbjct: 132 NLCLESYDRIEQTLKHCIEAKMLPADLMTRRA-AIIMRGYISGLMENWLFAPQSFDLKKE 190 Query: 175 LLDYFS 180 DY + Sbjct: 191 ARDYVA 196
>TCRTETA#Tetracycline resistance protein signature. Length = 399 Score = 37.1 bits (86), Expect = 1e-04 Identities = 50/275 (18%), Positives = 91/275 (33%), Gaps = 46/275 (16%) Query: 62 NTYGIFAAGY-----FFRPLGGVVMAHFGDLVGRKKLFSLSILLMALPTLFIGILPTFEN 116 YGI A Y P+ G D GR+ + +S+ A+ + P Sbjct: 43 AHYGILLALYALMQFACAPVLG----ALSDRFGRRPVLLVSLAGAAVDYAIMATAPFLW- 97 Query: 117 IGYLAPLLLLLMRVVQGIAIGGEIPAAWTFVSEHVPE----RKIGLANGLLTAGLSLGIL 172 +L + R+V GI G A ++++ R G + G+ G + Sbjct: 98 -------VLYIGRIVAGIT-GATGAVAGAYIADITDGDERARHFGFMSACFGFGMVAGPV 149 Query: 173 LGALMSLWISLNFSEGQIHDWAWRIPFIAGGIFGLVALYLRTYLKETPVFKAMQARKEIS 232 LG LM G PF A + +L + + + Sbjct: 150 LGGLM----------GGFSP---HAPFFAAAALNGLNFLTGCFLLPESHKGERRPLRREA 196 Query: 233 KEMPVKQVLKTHKTAVAIGMLFTWFLTGCVVVVILAMPNLLIGSFGFERAQ------TFE 286 T VA ++ +F+ + ++ +P L FG +R Sbjct: 197 LNPLASFRWARGMTVVAA-LMAVFFI----MQLVGQVPAALWVIFGEDRFHWDATTIGIS 251 Query: 287 MQSAAIVMQMVGCILAGYFADRFGCGKVMMVGALA 321 + + I+ + ++ G A R G + +M+G +A Sbjct: 252 LAAFGILHSLAQAMITGPVAARLGERRALMLGMIA 286
>DHBDHDRGNASE#2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase signature. Length = 261 Score = 100 bits (251), Expect = 1e-27 Identities = 71/257 (27%), Positives = 121/257 (47%), Gaps = 8/257 (3%) Query: 5 VEGKVAVVTGGSSGIGLAAVEILVAEGAKVAWCGRDEERLNASKHYILEKFPHANIFTKA 64 +EGK+A +TG + GIG A L ++GA +A + E+L + + HA F Sbjct: 6 IEGKIAFITGAAQGIGEAVARTLASQGAHIAAVDYNPEKLEKVVSSLKAEARHAEAF--P 63 Query: 65 CNVLKKEEVQQFAKDVKLNLGNVDMLINNAGQGRVSNFENTQDEDWMKEIELKYFSVLHP 124 +V + + ++ +G +D+L+N AG R + DE+W + V + Sbjct: 64 ADVRDSAAIDEITARIEREMGPIDILVNVAGVLRPGLIHSLSDEEWEATFSVNSTGVFNA 123 Query: 125 VRAFLDDLKQSANASITNVNSLLALQPEPHMIATSSARAALLNLTHSLAHEFTQYGVRVN 184 R+ + + SI V S A P M A +S++AA + T L E +Y +R N Sbjct: 124 SRSVSKYMMDRRSGSIVTVGSNPAGVPRTSMAAYASSKAAAVMFTKCLGLELAEYNIRCN 183 Query: 185 SILLGMVESA-QWKRRYETRSDLNLSWEEWTGNIAKNR-GIPMQRLGRPEEPARALVFLA 242 + G E+ QW +D N + + G++ + GIP+++L +P + A A++FL Sbjct: 184 IVSPGSTETDMQW----SLWADENGAEQVIKGSLETFKTGIPLKKLAKPSDIADAVLFLV 239 Query: 243 SPLASYTTGSAIDVSGG 259 S A + T + V GG Sbjct: 240 SGQAGHITMHNLCVDGG 256
>TCRTETA#Tetracycline resistance protein signature. Length = 399 Score = 41.3 bits (97), Expect = 4e-06 Identities = 74/366 (20%), Positives = 135/366 (36%), Gaps = 32/366 (8%) Query: 52 AKLGWLMTSFLLAYGFSSVFLSFLGDIFNPKKMLFWSVTSWGLLMFCMGFTTSYSGMLIL 111 A G L+ + L + L L D F + +L S+ + M + I Sbjct: 43 AHYGILLALYALMQFACAPVLGALSDRFGRRPVLLVSLAGAAVDYAIMATAPFLWVLYIG 102 Query: 112 RVLLGLAEGPLFALAYTIVKQTYTDHQQARA----STMFLLGTPIGAFLGFPITANVLAH 167 R++ G+ G A+A + ++AR S F G G P+ ++ Sbjct: 103 RIVAGIT-GATGAVAGAYIADITDGDERARHFGFMSACFGFGMVAG-----PVLGGLMGG 156 Query: 168 HDWHTTFFVMAGLTVIAIFSIVFGLRNLQL--KKTVEIDGESKRTNFKGHIANTKLLLSN 225 H FF A L + + F L ++ + + + +F+ T + Sbjct: 157 FSPHAPFFAAAALNGLNFLTGCFLLPESHKGERRPLRREALNPLASFRWARGMTVVAALM 216 Query: 226 SAFWLVCLFNIALMTYLWGLNS-----WVPSYLMQDKGFNLKEFGMYSSFPFIAMLIGEI 280 + F+++ L LW + W + G +L FG+ S AM+ G Sbjct: 217 AVFFIMQLVGQVPAA-LWVIFGEDRFHWDAT----TIGISLAAFGILHSL-AQAMITG-- 268 Query: 281 IGAFLSDKLGRRAIQVFSGLLLAGIFMYVMVIMTEPLLIIAAMSLSAMAWGFGVAAVFAL 340 ++ +LG R + G++ G ++ T + M L A + G G+ A+ A+ Sbjct: 269 ---PVAARLGERRA-LMLGMIADGTGYILLAFATRGWMAFPIMVLLA-SGGIGMPALQAM 323 Query: 341 LARVTTSNVGATAGGIFNGLGNFASAIAPVLIGYIVMQTHSFNLGITFLAAVAVIGSLFL 400 L+R G L + S + P+L I + + G ++A A+ L Sbjct: 324 LSRQVDEERQGQLQGSLAALTSLTSIVGPLLFTAIYAASITTWNGWAWIAGAALY--LLC 381 Query: 401 VPLLKR 406 +P L+R Sbjct: 382 LPALRR 387
>HTHTETR#TetR bacterial regulatory protein HTH signature. Length = 215 Score = 60.4 bits (146), Expect = 1e-13 Identities = 34/170 (20%), Positives = 72/170 (42%), Gaps = 14/170 (8%) Query: 12 RREEIMNAALDVIYEVGLSNTTIAQIAKKAELSTGIVSHYFGDKQGLINTCMQEMLNVLR 71 R+ I++ AL + + G+S+T++ +IAK A ++ G + +F DK L + + + + Sbjct: 12 TRQHILDVALRLFSQQGVSSTSLGEIAKAAGVTRGAIYWHFKDKSDLFSEIWELSESNIG 71 Query: 72 RKTEQYRAEADSHPESQIKAIIDSNFDISQVNEKAMRVWLDFWSASMH----VPDLSRLQ 127 +Y+A+ P S ++ I+ + S V E+ R+ ++ + + + Q Sbjct: 72 ELELEYQAKFPGDPLSVLREILIHVLE-STVTEERRRLLMEIIFHKCEFVGEMAVVQQAQ 130 Query: 128 KINDHRLYSNLKFYFLKLMNEQQ------ASVAARGLAALIDGL---WLR 168 + Y ++ + + AA + I GL WL Sbjct: 131 RNLCLESYDRIEQTLKHCIEAKMLPADLMTRRAAIIMRGYISGLMENWLF 180
>FbpA_PF05833#Fibronectin-binding protein Length = 577 Score = 28.7 bits (64), Expect = 0.028 Identities = 10/57 (17%), Positives = 26/57 (45%) Query: 210 QAIKEIKGLIPESVQIGAYANAFPPQDESATANDGLDEIRKDLDAPAYLGFAKQWQK 266 ++ + + ++ + Y + +A D ++EI+K+L Y+ F K ++ Sbjct: 395 KSEEAANEQLLQNEEELNYLYSVLTNINNADNYDEIEEIKKELIETGYIKFKKIYKS 451
>PF03544#Gram-negative bacterial tonB protein Length = 243 Score = 39.2 bits (91), Expect = 9e-06 Identities = 11/58 (18%), Positives = 29/58 (50%), Gaps = 1/58 (1%) Query: 241 VELRIRINEKGQPIDIQLRQSSGIASLDKRVMQATRKSRFKPHKINGRAVTIVVDFPV 298 V+++ + G+ ++Q+ + ++ V A R+ R++P K G + + + F + Sbjct: 180 VKVKFDVTPDGRVDNVQILSAKPANMFEREVKNAMRRWRYEPGK-PGSGIVVNILFKI 236
>TCRTETB#Tetracycline resistance protein TetB signature. Length = 458 Score = 51.0 bits (122), Expect = 5e-09 Identities = 39/174 (22%), Positives = 73/174 (41%), Gaps = 1/174 (0%) Query: 41 IATFFDAYTVLAIAFALPQLITEWHLTPAYVGAIIAAGYVGQLVGAIFFGSLAEKVGRLK 100 I +FF + + +LP + +++ PA + A + +G +G L++++G + Sbjct: 21 ILSFFSVLNEMVLNVSLPDIANDFNKPPASTNWVNTAFMLTFSIGTAVYGKLSDQLGIKR 80 Query: 101 VLSFTILLFVAMDISCLFAWSGMSLLIF-RFLQGVGTGGEVPVASAYINEFIGAEKRGKF 159 +L F I++ + S SLLI RF+QG G + + +I E RGK Sbjct: 81 LLLFGIIINCFGSVIGFVGHSFFSLLIMARFIQGAGAAAFPALVMVVVARYIPKENRGKA 140 Query: 160 FLLYEVLFPLGLMFAGMAAFFLMPIYGWKVMFIVGLIPSLLVIPLRFFLPESPR 213 F L + +G + W + ++ +I + V L L + R Sbjct: 141 FGLIGSIVAMGEGVGPAIGGMIAHYIHWSYLLLIPMITIITVPFLMKLLKKEVR 194
>TCRTETB#Tetracycline resistance protein TetB signature. Length = 458 Score = 107 bits (269), Expect = 3e-27 Identities = 88/397 (22%), Positives = 162/397 (40%), Gaps = 20/397 (5%) Query: 27 FMVVLDTTIANVSVPHITGNLAVSSTQGTWVVTSYAVAEAICVPLTGWLAGRFGTVRVFI 86 F VL+ + NVS+P I + WV T++ + +I + G L+ + G R+ + Sbjct: 24 FFSVLNEMVLNVSLPDIANDFNKPPASTNWVNTAFMLTFSIGTAVYGKLSDQLGIKRLLL 83 Query: 87 FGLIGFTIFSFLCGLANS-LGMLVFFRIGQGLCGGPLMPLSQTLLMRIFPQEKHAQAMGL 145 FG+I S + + +S +L+ R QG L ++ R P+E +A GL Sbjct: 84 FGIIINCFGSVIGFVGHSFFSLLIMARFIQGAGAAAFPALVMVVVARYIPKENRGKAFGL 143 Query: 146 WAMTTVVGPILGPILGGLISDNLSWHWIFFINIP-VGIVCVLAAIRLLKPAETETISLRI 204 +G +GP +GG+I+ + HW + + IP + I+ V ++LLK I Sbjct: 144 IGSIVAMGEGVGPAIGGMIAHYI--HWSYLLLIPMITIITVPFLMKLLKKEVRIKGHFDI 201 Query: 205 DTVGLGLLILWIGALQLMLDLGHERDWFNSTSIVVLGLTAAIGFVVFLIWELTDKHPVVD 264 G++++ +G + ML F S+ + F++F+ P VD Sbjct: 202 ----KGIILMSVGIVFFMLFTTSYSISFLIVSV--------LSFLIFVKHIRKVTDPFVD 249 Query: 265 VKVFRHRGFAISVLALSLGFGAFFGSIVLIPQWLQM--NLSYTATWAGYLTATMGFGSLT 322 + ++ F I VL + FG G + ++P ++ LS + + + Sbjct: 250 PGLGKNIPFMIGVLCGGIIFGTVAGFVSMVPYMMKDVHQLSTAEIGSVIIFPGTMSVIIF 309 Query: 323 MSPIVAKLSTKHDPRALASFGLILLGGVTLMRAFWTTDADFMALAWPQILQGFAVPFFFI 382 I L + P + + G+ L L +F + + + + F Sbjct: 310 -GYIGGILVDRRGPLYVLNIGVTFLSVSFLTASF-LLETTSWFMTIIIVFVLGGLSFTKT 367 Query: 383 PLSNIALGSVLQQEIASAAGLMNFLRTMAGAIGASIA 419 +S I S+ QQE + L+NF ++ G +I Sbjct: 368 VISTIVSSSLKQQEAGAGMSLLNFTSFLSEGTGIAIV 404
>RTXTOXIND#Gram-negative bacterial RTX secretion protein D signature. Length = 478 Score = 112 bits (282), Expect = 1e-29 Identities = 69/411 (16%), Positives = 157/411 (38%), Gaps = 70/411 (17%) Query: 25 KRKKFLGFFALILLIAAILYAIWALFLNNSVSTDNAYVGAETAQITSMVSGQVAQVVVKD 84 +R + + +F + L+ A + ++ + + + +I + + V +++VK+ Sbjct: 55 RRPRLVAYFIMGFLVIAFILSVLGQVEIVATANGKLTHSGRSKEIKPIENSIVKEIIVKE 114 Query: 85 TQTVHRGEVLVRIDDR--DAKIALAQAEAELAKAKRQYKQTAANSSSLNS---------- 132 ++V +G+VL+++ +A Q+ A+ ++ Q + S LN Sbjct: 115 GESVRKGDVLLKLTALGAEADTLKTQSSLLQARLEQTRYQILSRSIELNKLPELKLPDEP 174 Query: 133 -------QVVVRADE-----INSAKAQVAQAQADYDKAGLE------------------- 161 + V+R ++ + Q Q + + DK E Sbjct: 175 YFQNVSEEEVLRLTSLIKEQFSTWQNQKYQKELNLDKKRAERLTVLARINRYENLSRVEK 234 Query: 162 --LNRRAQLAASGAVSKEELTKAQSAVETAKAGLELAKAGLAQASSSRKAAESTLAANEA 219 L+ + L A++K + + ++ A L + K+ L Q S +A+ Sbjct: 235 SRLDDFSSLLHKQAIAKHAVLEQENKYVEAVNELRVYKSQLEQIESEILSAKEEYQLVTQ 294 Query: 220 LIQGVSEVST------PDVQVAQAHVEQAQLDLERTVIRAPVDGVVTRRNIQ-VGQRVAP 272 L + +E+ ++ + + + + + +VIRAPV V + + G V Sbjct: 295 LFK--NEILDKLRQTTDNIGLLTLELAKNEERQQASVIRAPVSVKVQQLKVHTEGGVVTT 352 Query: 273 GTSMMMIVPLND-LYVDANFKESQLKKVRPGQIVTLTSDLYGDDVEYHGKVMGFSGGTGS 331 ++M+IVP +D L V A + + + GQ + + + +G ++G Sbjct: 353 AETLMVIVPEDDTLEVTALVQNKDIGFINVGQNAIIKVEAF--PYTRYGYLVG------- 403 Query: 332 AFALIPAQNATGNWIKVVQRLPVRIALDPKELAEH----PLRVGLSMEAKV 378 I + +V V I+++ L+ PL G+++ A++ Sbjct: 404 KVKNINLDAIEDQRLGLVFN--VIISIEENCLSTGNKNIPLSSGMAVTAEI 452
>NUCEPIMERASE#Nucleotide sugar epimerase signature. Length = 334 Score = 45.2 bits (107), Expect = 2e-07 Identities = 42/241 (17%), Positives = 83/241 (34%), Gaps = 50/241 (20%) Query: 4 NVLITGASGFIGTHLIKFLLQKNYNVIAV-------------TRQA-----------GKK 39 L+TGA+GFIG H+ K LL+ + V+ + R Sbjct: 2 KYLVTGAAGFIGFHVSKRLLEAGHQVVGIDNLNDYYDVSLKQARLELLAQPGFQFHKIDL 61 Query: 40 SDHPALQWVQKFEDITTRQIDYVVNLAG-ANIGEKRWTGSRKKQLIESRVNTTRKLYAWL 98 +D + F + V + R++ +S + + Sbjct: 62 ADREGMT--DLFAS---GHFERVFISPHRLAV---RYSLENPHAYADSNLTGFLNILEGC 113 Query: 99 KQSEIFPEVIVSGSAIGYYGIDDQENWTEVCTEQSSPQPIFM----SKLCQEWEHAALAD 154 + ++I + S S++ YG++ + ++ + S P+ + K + H Sbjct: 114 RHNKIQHLLYASSSSV--YGLNRKMPFST---DDSVDHPVSLYAATKKANELMAHTYSHL 168 Query: 155 AQQNTKIIRLGVVFGQGGGILPKMLLP--IRLNLVGQ----IGHGRQPVVWVHIEDVLSA 208 +R V+G G P M L + L G+ +G+ + +I+D+ A Sbjct: 169 YGLPATGLRFFTVYGPWGR--PDMALFKFTKAMLEGKSIDVYNYGKMKRDFTYIDDIAEA 226 Query: 209 I 209 I Sbjct: 227 I 227
>RTXTOXIND#Gram-negative bacterial RTX secretion protein D signature. Length = 478 Score = 35.6 bits (82), Expect = 0.001 Identities = 32/175 (18%), Positives = 68/175 (38%), Gaps = 14/175 (8%) Query: 415 AQLQQNQIHLQQQLTQTQQYAVLDKGLSAHLHQLGQFIQNYQAIEQQLGNPTLARQKLSE 474 A + Q L Q + +Y +L + + L++L + + Q + + L Sbjct: 134 ADTLKTQSSLLQARLEQTRYQILSRSIE--LNKLPELKLPDEPYFQNVS----EEEVLRL 187 Query: 475 AKSELEQLVTSLGTVEQIELKLEQQRKDKDQKLAQIT----QLDLIQQKIIIYHELYAEL 530 EQ T Q EL L+++R ++ LA+I + + ++ + L + Sbjct: 188 TSLIKEQFSTWQNQKYQKELNLDKKRAERLTVLARINRYENLSRVEKSRLDDFSSLLHK- 246 Query: 531 QQFTEKQTQTSAQEQQLKTVCQLAEQEYQTSKTEREKLQHILQQQRLLHTENIEQ 585 Q K + + ++ V +L + Q + E E L +++ L T+ + Sbjct: 247 -QAIAKHAVLEQENKYVEAVNELRVYKSQLEQIESEILS--AKEEYQLVTQLFKN 298 Score = 32.5 bits (74), Expect = 0.012 Identities = 29/208 (13%), Positives = 62/208 (29%), Gaps = 17/208 (8%) Query: 168 AQSEVTAFLKARDSERGELLEYLTNSSIFAKIGELAFRKTADIAKQRKQLEEFLGHIEIL 227 A+++ + R E Y S + + Q EE L Sbjct: 132 AEADTLKTQSSLLQARLEQTRYQILSRSIELNKLPELKLPDEPYFQNVSEEEVLR----- 186 Query: 228 SDEEIAAFTEQYQQAEQNHHQLEQQKNVLDKQQQWFERKA-KLEQEVQAKQQQFQT---- 282 + EQ+ + +Q E + ++ + + E + ++ + Sbjct: 187 ---LTSLIKEQFSTWQNQKYQKELNLDKKRAERLTVLARINRYENLSRVEKSRLDDFSSL 243 Query: 283 -QQNHHQQLAGEREQLKRLEVFSEIRQQVFQQAQNLQTLQQLEPQIQQAQTKFNELVQVF 341 + + A ++ K +E +E+R Q Q + + + Q F + Sbjct: 244 LHKQAIAKHAVLEQENKYVEAVNELRVYKSQLEQIESEILSAKEEYQLVTQLFKNEIL-- 301 Query: 342 ETGQKQYQLAEQELKQTLDFEQQHQQAL 369 +Q L L ++ QQA Sbjct: 302 -DKLRQTTDNIGLLTLELAKNEERQQAS 328 Score = 30.6 bits (69), Expect = 0.043 Identities = 24/158 (15%), Positives = 53/158 (33%), Gaps = 26/158 (16%) Query: 610 DSAVSKALFDLQQQQEQQAVALEQTKFNAWQTQQH----ALTQCRAELEQVQKYLTQLKA 665 ++ +++ + +L + +F+ WQ Q++ L + RAE V + + + Sbjct: 169 KLPDEPYFQNVSEEEVLRLTSLIKEQFSTWQNQKYQKELNLDKKRAERLTVLARINRYEN 228 Query: 666 KQSSLQQELK------------------QQFSLNQLQIELNQAPEQILLMLNELRQAAQT 707 + L Q+ + EL Q+ + +E+ A + Sbjct: 229 LSRVEKSRLDDFSSLLHKQAIAKHAVLEQENKYVEAVNELRVYKSQLEQIESEILSAKEE 288 Query: 708 AI---NSFDSE-NVRLAQSIKQHNQLVQTIQRNESLLN 741 F +E +L Q+ L + +NE Sbjct: 289 YQLVTQLFKNEILDKLRQTTDNIGLLTLELAKNEERQQ 326
>SACTRNSFRASE#Streptothricin acetyltransferase signature. Length = 173 Score = 44.2 bits (104), Expect = 3e-08 Identities = 18/73 (24%), Positives = 31/73 (42%), Gaps = 1/73 (1%) Query: 66 MAVDPKMQGQGLGYELLNASIDQLKNQPV-QIFLEVRESNKAAIGLYEKTGFHQIDLRRN 124 +AV + +G+G LL+ +I+ K + LE ++ N +A Y K F + Sbjct: 95 IAVAKDYRKKGVGTALLHKAIEWAKENHFCGLMLETQDINISACHFYAKHHFIIGAVDTM 154 Query: 125 YYPTPEGGREHAV 137 Y E A+ Sbjct: 155 LYSNFPTANEIAI 167
>TCRTETOQM#Tetracycline resistance protein TetO/TetQ/TetM family signature. Length = 639 Score = 77.2 bits (190), Expect = 2e-17 Identities = 50/149 (33%), Positives = 77/149 (51%), Gaps = 5/149 (3%) Query: 13 VNVGTIGHVDHGKTTLTAAI--ATICAKTYGGEAKDYSQIDSAPEEKARGITINTSHVEY 70 +N+G + HVD GKTTLT ++ + G K ++ D+ E+ RGITI T + Sbjct: 4 INIGVLAHVDAGKTTLTESLLYNSGAITELGSVDKGTTRTDNTLLERQRGITIQTGITSF 63 Query: 71 DSPIRHYAHVDCPGHADYVKNMITGAAQMDGAILVCAATDGPMPQTREHILLSRQVGVPY 130 +D PGH D++ + + +DGAIL+ +A DG QTR R++G+P Sbjct: 64 QWENTKVNIIDTPGHMDFLAEVYRSLSVLDGAILLISAKDGVQAQTRILFHALRKMGIP- 122 Query: 131 IIVFLNKCDLVDDEELLELVEMEVRELLS 159 I F+NK D + L V +++E LS Sbjct: 123 TIFFINKIDQNGID--LSTVYQDIKEKLS 149
>TCRTETOQM#Tetracycline resistance protein TetO/TetQ/TetM family signature. Length = 639 Score = 596 bits (1538), Expect = 0.0 Identities = 168/686 (24%), Positives = 280/686 (40%), Gaps = 78/686 (11%) Query: 9 RYRNIGISAHIDAGKTTTTERILFYTGVSHKIGEVHDGAATMDWMEQEQERGITITSAAT 68 + NIG+ AH+DAGKTT TE +L+ +G ++G V G D E++RGITI + T Sbjct: 2 KIINIGVLAHVDAGKTTLTESLLYNSGAITELGSVDKGTTRTDNTLLERQRGITIQTGIT 61 Query: 69 TCFWSGMGNQFEQHRINVIDTPGHVDFTIEVERSMRVLDGACMVYCAVGGVQPQSETVWR 128 + W ++N+IDTPGH+DF EV RS+ VLDGA ++ A GVQ Q+ ++ Sbjct: 62 SFQWEN-------TKVNIIDTPGHMDFLAEVYRSLSVLDGAILLISAKDGVQAQTRILFH 114 Query: 129 QANKYKVPRLAFVNKMDRTGANFFRAVEQVKTRLGGNPVPIVVPIGAEDTFQGVVDLIEM 188 K +P + F+NK+D+ G + + +K +L V Q V M Sbjct: 115 ALRKMGIPTIFFINKIDQNGIDLSTVYQDIKEKLSAEIVIK----------QKVELYPNM 164 Query: 189 KAIIWDEASQGMKFEYADIPADLVDTSNEWRTKMVEAAAEASEELMDKYLEEGDLSKEEI 248 + E+ Q + E +++L++KY+ L E+ Sbjct: 165 CVTNFTESEQ------------------------WDTVIEGNDDLLEKYMSGKSLEALEL 200 Query: 249 IAGLRARTLASEIQVMLCGSAFKNKGVQRMLDAVIEFLPSPTEVKAIEGILDDKDETKAS 308 R + + GSA N G+ +++ + S T Sbjct: 201 EQEESIRFHNCSLFPVYHGSAKNNIGIDNLIEVITNKFYSSTH----------------- 243 Query: 309 REASDEAPFSALAFKIMNDKFVGNLTFVRVYSGVLKQGDPVYNPVKSKRERIGRIVQMHA 368 ++ FKI + L ++R+YSGVL D V K K +I + Sbjct: 244 ---RGQSELCGKVFKIEYSEKRQRLAYIRLYSGVLHLRDSVRISEKEK-IKITEMYTSIN 299 Query: 369 NERQDLDEIRAGDIAACVG----LKDVTTGDTLCDEKNIITLERMEFPEPVISLAVEPKT 424 E +D+ +G+I L V GDT + ER+E P P++ VEP Sbjct: 300 GELCKIDKAYSGEIVILQNEFLKLNSV-LGDTKLLPQR----ERIENPLPLLQTTVEPSK 354 Query: 425 KADQEKMSIALGRLAKEDPSFRVRTDEESGQTIIAGMGELHLDIIVDRMKREFGVEANIG 484 +E + AL ++ DP R D + + I++ +G++ +++ ++ ++ VE I Sbjct: 355 PQQREMLLDALLEISDSDPLLRYYVDSATHEIILSFLGKVQMEVTCALLQEKYHVEIEIK 414 Query: 485 KPMVAYRETIKKSVEQEGKFVRQTGGKGKFGHVYVRLEPLDVEEAGKEYQFVEEVVGGVV 544 +P V Y E K E + + + + + PL G Q+ V G + Sbjct: 415 EPTVIYMERPLKKA--EYTIHIEVPPNPFWASIGLSVSPL---PLGSGMQYESSVSLGYL 469 Query: 545 PKEFFGAVDKGIQERMKNGVLAGYPVVGIKATLFDGSYHDVDSDELSFKMAGSYAFRDGF 604 + F AV +GI+ + G L G+ V K G Y+ S F+M Sbjct: 470 NQSFQNAVMEGIRYGCEQG-LYGWNVTDCKICFKYGLYYSPVSTPADFRMLAPIVLEQVL 528 Query: 605 MKADPILLEPIMKVEVETPEDYMGDIMGDLNRRRGMVQGMDDLPGGTKAIKAEVPLAEMF 664 KA LLEP + ++ P++Y+ D + + L + E+P + Sbjct: 529 KKAGTELLEPYLSFKIYAPQEYLSRAYTDAPKYCANIVDT-QLKNNEVILSGEIPARCIQ 587 Query: 665 GYATQMRSMSQGRATYSMEFAKYAET 690 Y + + + GR+ E Y T Sbjct: 588 EYRSDLTFFTNGRSVCLTELKGYHVT 613
>PF06580#Sensor histidine kinase Length = 349 Score = 36.8 bits (85), Expect = 2e-04 Identities = 21/109 (19%), Positives = 42/109 (38%), Gaps = 24/109 (22%) Query: 431 VVQNLVGNAVRYC------DNKVRITGGVHSDGMAFVCVEDDGAGIPEQDRQRVFEAFAR 484 +VQ LV N +++ K+ + G +G + VE+ G+ + ++ Sbjct: 259 LVQTLVENGIKHGIAQLPQGGKILLKG-TKDNGTVTLEVENTGSLALKNTKE-------- 309 Query: 485 LDDSRTRASGGYGLGLSIVSRIAYWFGGEIKVDESPTLGGARFIMTWPA 533 S G GL ++ R+ +G E ++ S G ++ P Sbjct: 310 --------STGTGL-QNVRERLQMLYGTEAQIKLSEKQGKVNAMVLIPG 349
>HTHFIS#FIS bacterial regulatory protein HTH signature. Length = 484 Score = 87.2 bits (216), Expect = 6e-22 Identities = 33/137 (24%), Positives = 59/137 (43%), Gaps = 1/137 (0%) Query: 8 PKILIVEDDERLARLTQEYLIRNGLEVGVETDGNRAIRRIISEQPDLVVLDVMLPGADGL 67 IL+ +DD + + + L R G +V + ++ R I + DLVV DV++P + Sbjct: 4 ATILVADDDAAIRTVLNQALSRAGYDVRITSNAATLWRWIAAGDGDLVVTDVVMPDENAF 63 Query: 68 TVCREVRPHY-HQPILMLTARTEDMDQVLGLEMGADDYVAKPVQPRVLLARIRALLRRTD 126 + ++ P+L+++A+ M + E GA DY+ KP L+ I L Sbjct: 64 DLLPRIKKARPDLPVLVMSAQNTFMTAIKASEKGAYDYLPKPFDLTELIGIIGRALAEPK 123 Query: 127 KTVEDEVAQRIEFDDLV 143 + + LV Sbjct: 124 RRPSKLEDDSQDGMPLV 140
>HTHFIS#FIS bacterial regulatory protein HTH signature. Length = 484 Score = 28.6 bits (64), Expect = 0.028 Identities = 12/39 (30%), Positives = 22/39 (56%), Gaps = 1/39 (2%) Query: 2 NWDDTKILLAIGRTGG-LSRSAKLLGISVSTVHRRAVEL 39 + IL A+ T G ++A LLG++ +T+ ++ EL Sbjct: 435 EMEYPLILAALTATRGNQIKAADLLGLNRNTLRKKIREL 473
>HTHTETR#TetR bacterial regulatory protein HTH signature. Length = 215 Score = 67.3 bits (164), Expect = 4e-16 Identities = 29/186 (15%), Positives = 63/186 (33%), Gaps = 17/186 (9%) Query: 11 RPRQARSVATFEAILEAAARILESLGFAGFNTNAVAELAGVSIGSLYQYFPSKDALIVEL 70 R + + T + IL+ A R+ G + + +A+ AGV+ G++Y +F K L E+ Sbjct: 3 RKTKQEAQETRQHILDVALRLFSQQGVSSTSLGEIAKAAGVTRGAIYWHFKDKSDLFSEI 62 Query: 71 IRRERAKLSNHIVEAIQQHEAADLKEKLKLIIRAAVQHQLSRPQLARTLEFASELIGKDI 130 + + +E + L ++R + H L E L+ + I Sbjct: 63 WELSESNIGELELEYQAKFPGDPLS-----VLREILIHVLESTV----TEERRRLLMEII 113 Query: 131 EESELQHELETIISDLFIRSGISHAQTAAQDVIALSKGMINAAGIAGESDLNNLQQRVEK 190 ++ + + + + A + + +R Sbjct: 114 FHKCEFVGEMAVV--------QQAQRNLCLESYDRIEQTLKHCIEAKMLPADLMTRRAAI 165 Query: 191 AVFGYL 196 + GY+ Sbjct: 166 IMRGYI 171
>ARGDEIMINASE#Bacterial arginine deiminase signature. Length = 409 Score = 27.5 bits (61), Expect = 0.045 Identities = 17/88 (19%), Positives = 31/88 (35%), Gaps = 22/88 (25%) Query: 71 VLHSNGQVKTGFLDQYGRTGRIRSQEQEK--------------VKVLIGG---DEWHYYI 113 VL S+ ++ F+ Q+ I++ + +I G +E Y Sbjct: 79 VLVSSVALENKFISQFILEAEIKTDFTINLLKDYFSSLTIDNMISKMISGVVTEELKNYT 138 Query: 114 SRFGGTIEDNTYIKFLDFVGDPIPNLEF 141 S + F+ DP+PN+ F Sbjct: 139 SSLDDLVNGAN-----LFIIDPMPNVLF 161
>INTIMIN#Intimin signature. Length = 939 Score = 30.8 bits (69), Expect = 0.013 Identities = 17/57 (29%), Positives = 25/57 (43%), Gaps = 10/57 (17%) Query: 353 VRYDDDQWALNLGLGQR-FSPKWLGSVSVGWDSGAGDKVSTGGPTKGYYNLGVGAQY 408 RY D ++ NLG GQR F P+ + +V D + LG+G +Y Sbjct: 248 ARYIDSRFTANLGAGQRFFLPENMLGYNVFIDQDF---------SGDNTRLGIGGEY 295
>TCRTETA#Tetracycline resistance protein signature. Length = 399 Score = 36.7 bits (85), Expect = 2e-04 Identities = 58/299 (19%), Positives = 109/299 (36%), Gaps = 41/299 (13%) Query: 64 LMRPLGAIFLGAYVDRVGRRKGLIVTLSLMAIGTILITFVPGYETIGIIAPILVVIGRLL 123 LM+ A LGA DR GRR L+V+L+ A+ ++ P ++ IGR++ Sbjct: 54 LMQFACAPVLGALSDRFGRRPVLLVSLAGAAVDYAIMATAPFLW--------VLYIGRIV 105 Query: 124 QGFSAGVESGGVSIYLAEIATDKNRGFITSWQSGSQQIAVVFAALLGYWLNTILTTAQVG 183 G + G Y+A+I R + S +V +LG + G Sbjct: 106 AGIT-GATGAVAGAYIADITDGDERARHFGFMSACFGFGMVAGPVLGGLM---------G 155 Query: 184 EWGWRIPFLI-----GCLIIPLIFLFRRTLEETEDFKAQKTHPSTKEIFSTLASNWRIVL 238 + PF G + FL + + P +E + LAS +R Sbjct: 156 GFSPHAPFFAAAALNGLNFLTGCFLLPES-------HKGERRPLRREALNPLAS-FRWAR 207 Query: 239 AGMMMSAMTTTTF-------YFITVYTTVYAKRTLEMSVTDSLLATVFVGLSNFFWLPMG 291 +++A+ F ++ R + T + F L + + Sbjct: 208 GMTVVAALMAVFFIMQLVGQVPAALWVIFGEDRFHWDATTIGISLAAFGILHSLAQAMIT 267 Query: 292 GLLSDKIG-RRPVLVGITTLAIFTTYPVLSWLVSDISFTNLIITLAYFSFFFGMYNGTM 349 G ++ ++G RR +++G+ +A T Y +L++ +++ LA + Sbjct: 268 GPVAARLGERRALMLGM--IADGTGYILLAFATRGWMAFPIMVLLASGGIGMPALQAML 324
>TCRTETA#Tetracycline resistance protein signature. Length = 399 Score = 28.6 bits (64), Expect = 0.039 Identities = 13/46 (28%), Positives = 23/46 (50%), Gaps = 3/46 (6%) Query: 305 DRGFIFLLILVSASGLALMAFRNTPYMALLLIFHLATVMTFFITMP 350 +R + L ++ +G L+AF +MA ++ LA + I MP Sbjct: 276 ERRALMLGMIADGTGYILLAFATRGWMAFPIMVLLA---SGGIGMP 318
>HTHTETR#TetR bacterial regulatory protein HTH signature. Length = 215 Score = 61.6 bits (149), Expect = 4e-14 Identities = 27/181 (14%), Positives = 60/181 (33%), Gaps = 26/181 (14%) Query: 7 KILDTAEKLFNENSFVGVGVDLIRDESGCSKTTMYTYYKNKNQLVKSVLVARDERFKQSL 66 ILD A +LF++ + I +G ++ +Y ++K+K+ L + + + Sbjct: 15 HILDVALRLFSQQGVSSTSLGEIAKAAGVTRGAIYWHFKDKSDLFSEIWELSESNIGELE 74 Query: 67 LGYVGDATG------LEAINKILDWHTNWFRQDFFKGCLF------------VRAVAESN 108 L Y G E + +L+ R+ +F +A Sbjct: 75 LEYQAKFPGDPLSVLREILIHVLESTVTEERRRLLMEIIFHKCEFVGEMAVVQQAQRNLC 134 Query: 109 QDDQDII--SISKAHKQWIKVLIAQNCNVPNGEALSELIYTVIEGLISRFLVDGFDETLA 166 + D I ++ + + + + + ++ I GL+ +L L Sbjct: 135 LESYDRIEQTLKHCIEAKM---LPADLMT---RRAAIIMRGYISGLMENWLFAPQSFDLK 188 Query: 167 T 167 Sbjct: 189 K 189
>HTHFIS#FIS bacterial regulatory protein HTH signature. Length = 484 Score = 29.4 bits (66), Expect = 0.025 Identities = 10/19 (52%), Positives = 12/19 (63%) Query: 293 RDELIPLLSEHFLQKTAKE 311 R E IP L HF+Q+ KE Sbjct: 313 RAEDIPDLVRHFVQQAEKE 331
>TCRTETA#Tetracycline resistance protein signature. Length = 399 Score = 52.5 bits (126), Expect = 2e-09 Identities = 62/395 (15%), Positives = 123/395 (31%), Gaps = 29/395 (7%) Query: 34 ALLFAYFAMVVDGIDIMLLSYSLTSLKAEFGLSTFQAGALGSA----SLAGMGIGGILGG 89 L+ + +D + I L+ L L + S G +L +LG Sbjct: 6 PLIVILSTVALDAVGIGLIMPVLPGLLRDLVHSNDVTAHYGILLALYALMQFACAPVLGA 65 Query: 90 WACDKFGRVRTIANSVTFFSVATCLLGFTQSFEQFMALRFIGALGIGALYMACNTLMAEY 149 + D+FGR + S+ +V ++ R + + GA +A+ Sbjct: 66 LS-DRFGRRPVLLVSLAGAAVDYAIMATAPFLWVLYIGRIVAGI-TGATGAVAGAYIADI 123 Query: 150 VPTTYRTTVLGTLQTGQTVGYIAATLLAGAIIPDHGWRVLFFLTVVPAFVNIFLQRFVPE 209 R G + G +A +L G + F + + +PE Sbjct: 124 TDGDERARHFGFMSACFGFGMVAGPVLGGLMGGFSPHAPFFAAAALNGLNFLTGCFLLPE 183 Query: 210 PKSWQLTKIESLQGNRQPKERVVAEKPKSGSIYKQIFNNFKHRKMFLLWMTTAFFLQ-FG 268 +G R+P R A P + + + + M F +Q G Sbjct: 184 SH----------KGERRP-LRREALNPLASFRWARGM------TVVAALMAVFFIMQLVG 226 Query: 269 YYGINNWMPSYLETEVHMNFKNLT-SYMVGSYTAMILGKILAGYLADKFNRRAVFVFGTI 327 W+ + E H + + S + ++ G +A + R + G I Sbjct: 227 QVPAALWV-IFGEDRFHWDATTIGISLAAFGILHSLAQAMITGPVAARLGERRALMLGMI 285 Query: 328 ASAVFLPIIIFFNTPDNILYLLITFGFLYGIPYGVNATYMAESFSTDVRGTAIGGAYNIG 387 A ++ F +++ GI ++ + +G G + Sbjct: 286 ADGTGYILLAFATRGWMAFPIMVLLAS-GGIGMPALQAMLSRQVDEERQGQLQGSLAALT 344 Query: 388 RVGAAIAPATIGFL--ASGGTFTMAFIVMGAAYFV 420 + + + P + AS T+ + GAA ++ Sbjct: 345 SLTSIVGPLLFTAIYAASITTWNGWAWIAGAALYL 379
>NUCEPIMERASE#Nucleotide sugar epimerase signature. Length = 334 Score = 59.4 bits (144), Expect = 1e-11 Identities = 32/127 (25%), Positives = 52/127 (40%), Gaps = 9/127 (7%) Query: 16 TILVTGAAGFIGSRLIVDLLREGHQVIAALRNAATKKDKLLGFIATEGLVDPSISFVEYD 75 LVTGAAGFIG + LL GHQV+ + N D L E L P F + D Sbjct: 2 KYLVTGAAGFIGFHVSKRLLEAGHQVV-GIDNLNDYYDVSLKQARLELLAQPGFQFHKID 60 Query: 76 LSRDFKLDSLLADAQAKIHVIYHLAA----SFNWGISKAEAERTNIKSGLALIEWAATLK 131 L+ + L A ++ ++ A A+ +N+ L ++E Sbjct: 61 LADREGMTDLFASGH--FERVFISPHRLAVRYSLENPHAYAD-SNLTGFLNILE-GCRHN 116 Query: 132 QLERFIW 138 +++ ++ Sbjct: 117 KIQHLLY 123
>ACRIFLAVINRP#Acriflavin resistance protein family signature. Length = 1034 Score = 87.6 bits (217), Expect = 2e-19 Identities = 50/233 (21%), Positives = 97/233 (41%), Gaps = 15/233 (6%) Query: 726 QRYAKITILLKTGSN-----HRIKEILESLKTYMAGQLGDKAVVSFGGDVTQTIALTETM 780 + A + I L TG+N IK L L+ + G K + + D T + + Sbjct: 284 KPAAGLGIKLATGANALDTAKAIKAKLAELQPFFPQ--GMKVLYPY--DTTPFV---QLS 336 Query: 781 VHGKLMNILQISFAVFFISALVFRSFSAGLIVLTPLLFSILAIFGVMGWLDIPLNIPNSL 840 +H + + + VF + L ++ A LI + +L F ++ +N Sbjct: 337 IHEVVKTLFEAIMLVFLVMYLFLQNMRATLIPTIAVPVVLLGTFAILAAFGYSINTLTMF 396 Query: 841 ISAMAVGIGADYAIYFLYRLREILSEEGSDIKDAIRKTLSTAGKASLFVATAVAGGYGVL 900 +A+G+ D AI + + ++ E+ K+A K++S A + +A ++ + + Sbjct: 397 GMVLAIGLLVDDAIVVVENVERVMMEDKLPPKEATEKSMSQIQGALVGIAMVLSAVFIPM 456 Query: 901 SLSQG--FHVHQWLAMFIVIAMLFSVFATLIMVPTM-ILMLKPRFIFPSNKKN 950 + G +++ ++ IV AM SV LI+ P + +LKP K Sbjct: 457 AFFGGSTGAIYRQFSITIVSAMALSVLVALILTPALCATLLKPVSAEHHENKG 509 Score = 60.6 bits (147), Expect = 3e-11 Identities = 27/156 (17%), Positives = 64/156 (41%), Gaps = 10/156 (6%) Query: 793 FAVFFISALVFRSFSAGLIVLTPLLFSILAIFGVMGWLDIPLNIPNSLISAMAVGIGADY 852 VF A ++ S+S + V+ + I+ + + ++ + +G+ A Sbjct: 881 VVVFLCLAALYESWSIPVSVMLVVPLGIVGVLLAATLFNQKNDVYFMVGLLTTIGLSAKN 940 Query: 853 AIYFLYRLREILSEEGSDIKDAIRKTLSTAGKASL--FVATAVAGGYGVL----SLSQGF 906 AI + ++++ +EG + +A A + L + T++A GVL S G Sbjct: 941 AILIVEFAKDLMEKEGKGVVEATLM----AVRMRLRPILMTSLAFILGVLPLAISNGAGS 996 Query: 907 HVHQWLAMFIVIAMLFSVFATLIMVPTMILMLKPRF 942 + + ++ M+ + + VP ++++ F Sbjct: 997 GAQNAVGIGVMGGMVSATLLAIFFVPVFFVVIRRCF 1032 Score = 43.7 bits (103), Expect = 5e-06 Identities = 41/223 (18%), Positives = 82/223 (36%), Gaps = 30/223 (13%) Query: 395 VLVIGLLHFEAFRSKQGLILPLVTALLSVTWGMGMMGLFKQPMDIFNSPTPILILAIAAG 454 V ++ L + R+ + + LL + G + +F ++LAI Sbjct: 351 VFLVMYLFLQNMRATLIPTIAVPVVLLGTFAILAAFGYSINTLTMFG-----MVLAIGLL 405 Query: 455 --HAVQLLKRYYEDFDRLIAQGMEPKTANSEAVVQSMVRVGPVMILAGGIAAAGFFSLLT 512 A+ +++ ++ + PK EA +SM ++ ++ + +A F + Sbjct: 406 VDDAIVVVENVE---RVMMEDKLPPK----EATEKSMSQIQGALVGIAMVLSAVFIPMAF 458 Query: 513 FNIPT---IRSFGIFTGIGIISTLIIEMTFIPVLRSML--PPPSVTKVARKGLPIW---- 563 F T R F I + ++++ + P L + L P + + G W Sbjct: 459 FGGSTGAIYRQFSITIVSAMALSVLVALILTPALCATLLKPVSAEHHENKGGFFGWFNTT 518 Query: 564 -DWIPKRIGDV---ILSVRPRMMLMTVIAVLG---VFLALGTS 599 D + IL R +L+ + V G +FL L +S Sbjct: 519 FDHSVNHYTNSVGKILGSTGRYLLIYALIVAGMVVLFLRLPSS 561 Score = 36.7 bits (85), Expect = 7e-04 Identities = 30/186 (16%), Positives = 69/186 (37%), Gaps = 23/186 (12%) Query: 366 MTISVGGNPVYLDKAEDYSKRINILFPIAVLVIGLLHFEAFRSKQGLILPLVTALLSVTW 425 + G + + L I+ +V+ L + S + ++ L + Sbjct: 854 IGYDWTGMSYQERLSG---NQAPALVAISFVVVFLCLAALYESWSIPVSVMLVVPLGIVG 910 Query: 426 GMGMMGLFKQPMDIFNSPTPILILAIAAGHAVQLLKRYYEDF--DRLIAQGMEPKTANSE 483 + LF Q D++ + + ++A +A+ ++ +F D + +G A Sbjct: 911 VLLAATLFNQKNDVYFMVGLLTTIGLSAKNAILIV-----EFAKDLMEKEGKGVVEATLM 965 Query: 484 AVVQSMVRVGPVMILAGGIAAAGFFSLLTFNIPTIRSFGIFTGI------GIISTLIIEM 537 AV +R+ P+++ + A +L I G + G++S ++ + Sbjct: 966 AVR---MRLRPILM----TSLAFILGVLPLAISNGAGSGAQNAVGIGVMGGMVSATLLAI 1018 Query: 538 TFIPVL 543 F+PV Sbjct: 1019 FFVPVF 1024
>ISCHRISMTASE#Isochorismatase signature. Length = 312 Score = 25.7 bits (56), Expect = 0.024 Identities = 19/73 (26%), Positives = 34/73 (46%), Gaps = 5/73 (6%) Query: 12 IRTLVAKEMRVEPETINPDQKFTSYGLDSIVALSVSGDLEDLTKL--ELEPTLLWDYPTI 69 IR +A+ ++ PE I + GLDS+ +++ +E + E+ L + PTI Sbjct: 235 IRKQIAELLQETPEDITDQEDLLDRGLDSVRIMTL---VEQWRREGAEVTFVELAERPTI 291 Query: 70 NALAEYLVSELQQ 82 + L + QQ Sbjct: 292 EEWQKLLTTRSQQ 304
>AUTOINDCRSYN#Autoinducer synthesis protein signature. Length = 216 Score = 128 bits (323), Expect = 1e-39 Identities = 33/144 (22%), Positives = 60/144 (41%), Gaps = 5/144 (3%) Query: 21 SYRYKVFVEHLGWELNCPNNEELDQFDKIDTAYVVAQDRESNIIGCARLLPTTQPYLLGE 80 + R + F + L W + C + E DQ+D +T Y+ ++ +I R + T P ++ Sbjct: 22 TLRKETFKDRLNWAVQCTDGMEFDQYDNNNTTYLFGIK-DNTVICSLRFIETKYPNMITG 80 Query: 81 IFPQLMNGMPIPCSPEIWELSRFSAVDFSNPPTSANQAVSSPVSIAILQEAINFARKQGA 140 F + IP E SRF VD S P+S + IN+++ +G Sbjct: 81 TFFPYFKEINIPEGN-YLESSRF-FVDKSRAKDILGNE--YPISSMLFLSMINYSKDKGY 136 Query: 141 KQLITTSPLGVERLLRAAGFRAHR 164 + T + +L+ +G+ Sbjct: 137 DGIYTIVSHPMLTILKRSGWGIRV 160
>TCRTETB#Tetracycline resistance protein TetB signature. Length = 458 Score = 28.7 bits (64), Expect = 0.049 Identities = 61/398 (15%), Positives = 124/398 (31%), Gaps = 100/398 (25%) Query: 75 LGGLVFGHFGDKIGRKSMLLLTLMLMGIPTVLIGLLPTYESIGYWAAICLVVLRFIQGMA 134 +G V+G D++G K +LL +++ +V+ + ++ S+ L++ RFIQG Sbjct: 64 IGTAVYGKLSDQLGIKRLLLFGIIINCFGSVIGFVGHSFFSL-------LIMARFIQGA- 115 Query: 135 MGGEWGGAVLMAV------EHAPEGGKGFWGSLPQASTGGGLMLASIALGLVSLLPEQAL 188 G A++M V + G GS+ G G + + + Sbjct: 116 -GAAAFPALVMVVVARYIPKENRGKAFGLIGSIVAMGEGVGPAIGGMIAHYI-------- 166 Query: 189 FSWGWRLPFLASIILLAVGWYIRVKVPESPDFEKVKQQSEEVKVPALQVFKNHPKQLITI 248 W L +I + ++ + + ++K + + + V I Sbjct: 167 ---HWSYLLLIPMITIITVPFLMKLLKKE---VRIKGHFDIKGIILMSVG-------IVF 213 Query: 249 ILARAAENAW-FYIASTFTLAYTTAQ--------------------LGIARQDILFATIC 287 + + F I S + +G+ I+F T+ Sbjct: 214 FMLFTTSYSISFLIVSVLSFLIFVKHIRKVTDPFVDPGLGKNIPFMIGVLCGGIIFGTVA 273 Query: 288 GAIVIL----------------------------FMTPLCGHLSDKVGQRNMFMFGLCIL 319 G + ++ + G L D+ G + G+ L Sbjct: 274 GFVSMVPYMMKDVHQLSTAEIGSVIIFPGTMSVIIFGYIGGILVDRRGPLYVLNIGVTFL 333 Query: 320 ALYCYPFFTMLNTKDPVLVWTAIVLAIGVVFPIMYAPQAQLFARQF------PAEIRYSG 373 ++ F T + + I +VF + + E +G Sbjct: 334 SV---SFLTASFLLETTSWFMTI----IIVFVLGGLSFTKTVISTIVSSSLKQQEAG-AG 385 Query: 374 ISISVQLAGVLGGGLAPLIATKLLSIGQGNPYLIMIYI 411 +S+ + L G I LLSI + L+ + + Sbjct: 386 MSL-LNFTSFLSEGTGIAIVGGLLSIPLLDQRLLPMEV 422
>TCRTETA#Tetracycline resistance protein signature. Length = 399 Score = 45.2 bits (107), Expect = 2e-07 Identities = 62/337 (18%), Positives = 111/337 (32%), Gaps = 17/337 (5%) Query: 58 AYAGQLIAVYALGSVLAAIPLISLTRSWNRRPLLLSAIAGLLLFNAITALSNDYILTLIA 117 A+ G L+A+YAL A L +L+ + RRP+LL ++AG + AI A + + I Sbjct: 43 AHYGILLALYALMQFACAPVLGALSDRFGRRPVLLVSLAGAAVDYAIMATAPFLWVLYIG 102 Query: 118 RFIAGMAAGVIWGLLAGYVRRMVAASYQGRALAIAGVGQPIALSIGVPLGAWLGTLFEWR 177 R +AG+ + Y+ + + R + G LG +G F Sbjct: 103 RIVAGITGATG-AVAGAYIADITDGDERARHFGFMSACFGFGMVAGPVLGGLMGG-FSPH 160 Query: 178 GVFWIMSLLALILFFWIRFSIPD--------FAGQSAQKRLPILKVLLMPGIRAILAVVF 229 F+ + L + F F +P+ ++ M + A++AV F Sbjct: 161 APFFAAAALNGLNFLTGCFLLPESHKGERRPLRREALNPLASFRWARGMTVVAALMAVFF 220 Query: 230 LWILAHSILYTYISPFLASTGQPYNVETILFIFGISSIVGILITGMFIDHSLRK-----I 284 + L + F ++ TI I+ L M + Sbjct: 221 IMQLVGQVPAALWVIFGEDRFH-WDATTIGISLAAFGILHSLAQAMITGPVAARLGERRA 279 Query: 285 TILSLFIFAIATALLGVYSSSSFVVLVGVVLWGVTFGGAPTLLQTALANTAGHEADVAQS 344 +L + LL + + V+L G P L Q Sbjct: 280 LMLGMIADGTGYILLAFATRGWMAFPIMVLLASGGI-GMPALQAMLSRQVDEERQGQLQG 338 Query: 345 MLVTVFNLAIASGGMVGGGLLESFGAAYFPWFMLVFA 381 L + +L G ++ + + + W + A Sbjct: 339 SLAALTSLTSIVGPLLFTAIYAASITTWNGWAWIAGA 375
>HTHTETR#TetR bacterial regulatory protein HTH signature. Length = 215 Score = 63.5 bits (154), Expect = 8e-15 Identities = 28/165 (16%), Positives = 70/165 (42%), Gaps = 10/165 (6%) Query: 9 DEIADAAMQVFWRRGYAATSVQDLVDGTGLSRSSLYSTFQNKQGLYQKALQR-YELLTTL 67 I D A+++F ++G ++TS+ ++ G++R ++Y F++K L+ + + + L Sbjct: 14 QHILDVALRLFSQQGVSSTSLGEIAKAAGVTRGAIYWHFKDKSDLFSEIWELSESNIGEL 73 Query: 68 NNVKLLSGSGSAKVLIRQLLLNIVEDELSDPEHKGCLV-----ANACLELAGHDEDVAQF 122 G ++R++L++++E +++ + + E+A + Sbjct: 74 ELEYQAKFPGDPLSVLREILIHVLESTVTEERRRLLMEIIFHKCEFVGEMAVVQQAQRNL 133 Query: 123 VVSNLQKIQHALESLFIKAQQSGEIPSTQNPRALASFFVNTIQGL 167 + + +I E ++ +P+ R A I GL Sbjct: 134 CLESYDRI----EQTLKHCIEAKMLPADLMTRRAAIIMRGYISGL 174
>DHBDHDRGNASE#2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase signature. Length = 261 Score = 39.6 bits (92), Expect = 5e-06 Identities = 26/77 (33%), Positives = 34/77 (44%) Query: 4 NIIIFGYGTGISKAVAHKFGKEGYKIGLVARNAEKLEKAILELKTQGIEAYTFTCDLAVL 63 I G GI +AVA +G I V N EKLEK + LK + A F D+ Sbjct: 10 IAFITGAAQGIGEAVARTLASQGAHIAAVDYNPEKLEKVVSSLKAEARHAEAFPADVRDS 69 Query: 64 EDIPNLVKRIKDQFGEI 80 I + RI+ + G I Sbjct: 70 AAIDEITARIEREMGPI 86
>ANTHRAXTOXNA#Anthrax toxin LF subunit signature. Length = 800 Score = 32.8 bits (74), Expect = 0.002 Identities = 17/46 (36%), Positives = 26/46 (56%), Gaps = 4/46 (8%) Query: 232 LALYPLSAFRAMNK----AAETVYETLRKEGTQKNVVDIMQTRKEL 273 L LY F MNK E + E+L+KEG +K+ +D+++ K L Sbjct: 257 LELYAPDMFEYMNKLEKGGFEKISESLKKEGVEKDRIDVLKGEKAL 302
>PF04183#IucA / IucC family Length = 580 Score = 29.5 bits (66), Expect = 0.047 Identities = 18/90 (20%), Positives = 37/90 (41%), Gaps = 17/90 (18%) Query: 457 ALRRNDREWVEQLPAEMENKIIHKLYYGHFFCHVFHQDYILKK-GHDPLEMEHQMWKLLD 515 +L + R+ +L A+ +IH L GHF + ++ + G E + ++LL Sbjct: 459 SLPQEVRDVTSRLSADY---LIHDLQTGHFVTVLRFISPLMVRLGVP----ERRFYQLLA 511 Query: 516 ARRAEYPAEHNVGHLYIAKPALANFYQKLD 545 A ++Y +H P ++ + Sbjct: 512 AVLSDYMKKH---------PQMSERFALFS 532
>FLGMRINGFLIF#Flagellar M-ring protein signature. Length = 559 Score = 33.0 bits (75), Expect = 0.004 Identities = 26/124 (20%), Positives = 41/124 (33%), Gaps = 18/124 (14%) Query: 216 VTSVLLPNRKVSEQDILQILQQHHLVQPLEDNEKEYSNIVIVMEESFWDSHHLDNGFSKD 275 VT L P R + E I + HLV N+ +V + + +G + Sbjct: 175 VTVTLEPGRALDEGQISAV---VHLVSSAVAGLPP-GNVTLVDQSGHLLTQSNTSGRDLN 230 Query: 276 LLSFVH--------QNQISNLLSPSFGGG------TANVEFEVLTSLNTTFFPNELLYVS 321 Q +I +LSP G G TA ++F + PN + Sbjct: 231 DAQLKFANDVESRIQRRIEAILSPIVGNGNVHAQVTAQLDFANKEQTEEHYSPNGDASKA 290 Query: 322 KLKK 325 L+ Sbjct: 291 TLRS 294
>NUCEPIMERASE#Nucleotide sugar epimerase signature. Length = 334 Score = 171 bits (435), Expect = 7e-53 Identities = 84/348 (24%), Positives = 143/348 (41%), Gaps = 35/348 (10%) Query: 3 KILVTGGAGYIGSHTCVELLNAGHEVIVFDNLSNSSEESL--TRVQDITQKSLAFVKGDI 60 K LVTG AG+IG H LL AGH+V+ DNL++ + SL R++ + Q F K D+ Sbjct: 2 KYLVTGAAGFIGFHVSKRLLEAGHQVVGIDNLNDYYDVSLKQARLELLAQPGFQFHKIDL 61 Query: 61 RNVNELDRVFQDHSIDAVIHFAGLKAVGESQEKPLIYFDNNIAGSIQLVKSMEKAGVYTL 120 + + +F + V AV S E P Y D+N+ G + +++ + L Sbjct: 62 ADREGMTDLFASGHFERVFISPHRLAVRYSLENPHAYADSNLTGFLNILEGCRHNKIQHL 121 Query: 121 VFSSSATVYDEANISPLNEDMPTGMPSNNYGYTKLIVEQLLQKLSNSDSKWSIALLRYFN 180 +++SS++VY P + D P + Y TK E + S+ LR+F Sbjct: 122 LYASSSSVYGLNRKMPFSTDDSVDHPVSLYAATKKANELMAHTYSHL-YGLPATGLRFFT 180 Query: 181 PVGAHKSGRIGEDPQGIPNNLMPYVTQVAVGRREKLSIYGNDYNTVDGTGVRDYIHVVDL 240 G P G P+ + T+ A+ + + +Y G RD+ ++ D+ Sbjct: 181 VYG----------PWGRPDMALFKFTK-AMLEGKSIDVYN------YGKMKRDFTYIDDI 223 Query: 241 ANAHLCALNNRLEVTGC---------------RAWNIGTGNGSSVLQVKNTFEQVNGVPV 285 A A + + R +NIG + ++ E G+ Sbjct: 224 AEAIIRLQDVIPHADTQWTVETGTPAASIAPYRVYNIGNSSPVELMDYIQALEDALGIEA 283 Query: 286 AFEFAPRRAGDVATSFADNARAVAELGWQPQYGLEDMLKDSWNWQKQN 333 P + GDV + AD +G+ P+ ++D +K+ NW + Sbjct: 284 KKNMLPLQPGDVLETSADTKALYEVIGFTPETTVKDGVKNFVNWYRDF 331
>PF05616#Neisseria meningitidis TspB protein Length = 501 Score = 30.1 bits (67), Expect = 0.023 Identities = 11/24 (45%), Positives = 18/24 (75%) Query: 104 LRLPVDYSKFPELTAQVHSQLQRM 127 +RL DYS+FPE+ + SQ++R+ Sbjct: 152 MRLMSDYSRFPEVKELMESQMERL 175
>INFPOTNTIATR#Macrophage infectivity potentiator signature. Length = 233 Score = 29.2 bits (65), Expect = 0.007 Identities = 19/79 (24%), Positives = 37/79 (46%), Gaps = 2/79 (2%) Query: 3 EIIQPNEEIRITDGSKVDLHFSVAIENGVEIDNTRNREEPVTLTIGDGNLLPGFEKALFG 62 +II + V + ++ + +G D+T +P T + ++PG+ +AL Sbjct: 131 KIIDAGTGAKPGKSDTVTVEYTGTLIDGTVFDSTEKAGKPATFQVS--QVIPGWTEALQL 188 Query: 63 LRAGDRRTVHLPPEDAFGP 81 + AG V +P + A+GP Sbjct: 189 MPAGSTWEVFVPADLAYGP 207
>HTHTETR#TetR bacterial regulatory protein HTH signature. Length = 215 Score = 67.7 bits (165), Expect = 4e-16 Identities = 36/179 (20%), Positives = 71/179 (39%), Gaps = 7/179 (3%) Query: 6 QSGRPKDLEKRARILQAAKAIFLKSGYHGTSMNQIAQEAGVTKLTVYNHFQDKANLFICA 65 + + + E R IL A +F + G TS+ +IA+ AGVT+ +Y HF+DK++LF Sbjct: 3 RKTKQEAQETRQHILDVALRLFSQQGVSSTSLGEIAKAAGVTRGAIYWHFKDKSDLFS-E 61 Query: 66 ITQTCEETLNPKQFELDASV--DFYQALFIVCSRALQIIYSPEALKLEHVL---FELAAE 120 I + E + + E A D L + L+ + E +L + Sbjct: 62 IWELSESNIGELELEYQAKFPGDPLSVLREILIHVLESTVTEERRRLLMEIIFHKCEFVG 121 Query: 121 QSPLAEQFFDASHTRLQNQLAAFFQKAAELGFIQAD-DPIYQTELLLTLLLGVRHHKVL 178 + + +Q +++ + E + AD ++ + G+ + + Sbjct: 122 EMAVVQQAQRNLCLESYDRIEQTLKHCIEAKMLPADLMTRRAAIIMRGYISGLMENWLF 180
>PF06580#Sensor histidine kinase Length = 349 Score = 30.6 bits (69), Expect = 0.013 Identities = 20/103 (19%), Positives = 34/103 (33%), Gaps = 25/103 (24%) Query: 347 LITNAIKY----TPKGGTITIGWHDDGEHAFFSVQDTGIGINPKHLPRLTERFYRVDSDR 402 L+ N IK+ P+GG I + D V++TG Sbjct: 263 LVENGIKHGIAQLPQGGKILLKGTKDNGTVTLEVENTGSLALK----------------- 305 Query: 403 SRQTGGTGLGLAIVKH---VLMQHGAYLDVQSKENEGSTFTAV 442 TG GL V+ +L A + + K+ + + + Sbjct: 306 -NTKESTGTGLQNVRERLQMLYGTEAQIKLSEKQGKVNAMVLI 347
>HTHFIS#FIS bacterial regulatory protein HTH signature. Length = 484 Score = 82.2 bits (203), Expect = 3e-20 Identities = 32/123 (26%), Positives = 60/123 (48%), Gaps = 3/123 (2%) Query: 6 ILIVDDELPIREMIHTSLDMAGFQCLQAEDAKQAHQIIVDQRPALILLDWMLPGGVSGVD 65 IL+ DD+ IR +++ +L AG+ +A + I L++ D ++P + D Sbjct: 6 ILVADDDAAIRTVLNQALSRAGYDVRITSNAATLWRWIAAGDGDLVVTDVVMPDE-NAFD 64 Query: 66 LCRRLKRDENLAEIPVIMLTARGEEDHKVQGLDAGADDYMTKPFSTRELVSRIKAVLRRA 125 L R+K+ ++PV++++A+ ++ + GA DY+ KPF EL+ I L Sbjct: 65 LLPRIKKAR--PDLPVLVMSAQNTFMTAIKASEKGAYDYLPKPFDLTELIGIIGRALAEP 122 Query: 126 NAL 128 Sbjct: 123 KRR 125
>HTHTETR#TetR bacterial regulatory protein HTH signature. Length = 215 Score = 61.2 bits (148), Expect = 1e-13 Identities = 25/175 (14%), Positives = 62/175 (35%), Gaps = 5/175 (2%) Query: 27 SERKEARREKLIEAGIATYGTLGFFSVTVKDVCQEAKLTERYFYESFKKSEDLFQTIFLK 86 + + R+ +++ + + G S ++ ++ + A +T Y FK DLF I+ Sbjct: 6 KQEAQETRQHILDVALRLFSQQGVSSTSLGEIAKAAGVTRGAIYWHFKDKSDLFSEIWEL 65 Query: 87 MIEELQQNLMQAVIKATPDPEKMVDAGLRALLTTLKDDPRLARIIYVDAVLVQELHNQAT 146 + + ++ K DP ++ L +L + + R ++ + + + A Sbjct: 66 SESNIGELELEYQAKFPGDPLSVLREILIHVLESTVTEERRRLLMEIIFHKCEFVGEMAV 125 Query: 147 IQETLTQFD-RMIQAFVMLTMPQIQHHE----NELSLIATGLNGYVTQIAIRWVM 196 +Q+ I+ A + GY++ + W+ Sbjct: 126 VQQAQRNLCLESYDRIEQTLKHCIEAKMLPADLMTRRAAIIMRGYISGLMENWLF 180
>DHBDHDRGNASE#2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase signature. Length = 261 Score = 74.3 bits (182), Expect = 1e-17 Identities = 52/202 (25%), Positives = 92/202 (45%), Gaps = 3/202 (1%) Query: 2 KNFKNKVAAITGAGSGIGQQLAILLAKQGCHLSLSDINEKGLQQTVELLKPYSNITVTTK 61 K + K+A ITGA GIG+ +A LA QG H++ D N + L++ V LK + Sbjct: 4 KGIEGKIAFITGAAQGIGEAVARTLASQGAHIAAVDYNPEKLEKVVSSLKAEAR-HAEAF 62 Query: 62 KLDVSDRDAVKQWAQETVQDHGSVNLIFNNAGVALGSTVEGATYEDLEWIVGINFWGVVY 121 DV D A+ + ++ G ++++ N AGV + + E+ E +N GV Sbjct: 63 PADVRDSAAIDEITARIEREMGPIDILVNVAGVLRPGLIHSLSDEEWEATFSVNSTGVFN 122 Query: 122 GTKEFLPFIKQTQDGHIINISSLFGLTAQPTQSGYNATKFAVRGFTESLRQELDIEKSGV 181 ++ ++ + G I+ + S + + + Y ++K A FT+ L EL + + Sbjct: 123 ASRSVSKYMMDRRSGSIVTVGSNPAGVPRTSMAAYASSKAAAVMFTKCLGLEL--AEYNI 180 Query: 182 SSLCVHPGGIRTNIAKSAKMSD 203 V PG T++ S + Sbjct: 181 RCNIVSPGSTETDMQWSLWADE 202
>TCRTETB#Tetracycline resistance protein TetB signature. Length = 458 Score = 52.2 bits (125), Expect = 2e-09 Identities = 72/360 (20%), Positives = 127/360 (35%), Gaps = 44/360 (12%) Query: 55 LPAFSQSFQISPASSSLALSLTTAFLAISIVLSSAFSQAIGRRGVIFSSMLCAAILNIVA 114 LP + F PAS++ + +I + S +G + ++ ++ +++ Sbjct: 37 LPDIANDFNKPPASTNWVNTAFMLTFSIGTAVYGKLSDQLGIKRLLLFGIIINCFGSVIG 96 Query: 115 MFTPNWHSLLI-ARALEGLLLGGVPAVTMAWIAEEIAPEYLGKTMGLYIAGTAFGGMMGR 173 ++ SLLI AR ++G PA+ M +A I E GK GL + A G +G Sbjct: 97 FVGHSFFSLLIMARFIQGAGAAAFPALVMVVVARYIPKENRGKAFGLIGSIVAMGEGVGP 156 Query: 174 VGMGILIEYFSW---------------------------RTALGLLGAICFICSIAFLNL 206 G++ Y W + + G I I F L Sbjct: 157 AIGGMIAHYIHWSYLLLIPMITIITVPFLMKLLKKEVRIKGHFDIKGIILMSVGIVFFML 216 Query: 207 LP--ASRNFVQKKGLNLNFHLQMWRTHLSNFKLLRLFTIGFLLTSVFV--TLFNYATFRL 262 S +F+ L+ ++ R F L + V +F + Sbjct: 217 FTTSYSISFLIVSVLSFLIFVKHIRKVTDPFVDPGLGKNIPFMIGVLCGGIIFGTVAGFV 276 Query: 263 SAAPYSLSQTQ--------ISLIFLSYSFGMVSSSLAGTLADRFGKKTMMMSGFALMIVG 314 S PY + +IF ++ + G L DR G ++ G + V Sbjct: 277 SMVPYMMKDVHQLSTAEIGSVIIFPGTMSVIIFGYIGGILVDRRGPLYVLNIGVTFLSVS 336 Query: 315 SL---MTLLSSLFGIIIGIAFITTGFFITHSLTSSSVGAESKQAKAHAS-SLYLLFYYMG 370 L L ++ + + I I F+ G T ++ S+ V + KQ +A A SL ++ Sbjct: 337 FLTASFLLETTSWFMTIIIVFVLGGLSFTKTVISTIVSSSLKQQEAGAGMSLLNFTSFLS 396
>ACRIFLAVINRP#Acriflavin resistance protein family signature. Length = 1034 Score = 487 bits (1254), Expect = e-157 Identities = 225/1040 (21%), Positives = 460/1040 (44%), Gaps = 52/1040 (5%) Query: 6 LSSWGLQHRTLIIFAMLLSLLLGTVAYFKLGRAEDPNLTIKVMTIDVNWPGATTRDLEQQ 65 ++++ ++ ++ ++ G +A +L A+ P + +++ N+PGA + ++ Sbjct: 1 MANFFIRRPIFAWVLAIILMMAGALAILQLPVAQYPTIAPPAVSVSANYPGADAQTVQDT 60 Query: 66 VVEKIQRTLQEVPNYDYVQSY-VRPGQATIFLVLKDWTRKSQIEESWYQARKRVNDIRQN 124 V + I++ + + N Y+ S G TI L + T + + Q + ++ Sbjct: 61 VTQVIEQNMNGIDNLMYMSSTSDSAGSVTITLTFQSGT---DPDIAQVQVQNKLQLATPL 117 Query: 125 LPQDIQGP-FFNDDFGDTFGSIYAFHADGFDDVQM---KQVLLSTRDHLLQVPDVSKVIL 180 LPQ++Q + ++ + F +D Q V + +D L ++ V V L Sbjct: 118 LPQEVQQQGISVEKSSSSYLMVAGFVSDNPGTTQDDISDYVASNVKDTLSRLNGVGDVQL 177 Query: 181 LGVQEPRFYIEFNYAKLAQLGISPLDLVNELQKQNAVEPAGTFEGPHA------RIYARV 234 G + I + L + ++P+D++N+L+ QN AG G A Sbjct: 178 FG-AQYAMRIWLDADLLNKYKLTPVDVINQLKVQNDQIAAGQLGGTPALPGQQLNASIIA 236 Query: 235 DGDVKSVQDLKNIVVQVGTH--NIHLGDVAHIDKGFIDPPQMSMRRNGERVTGLAVSMTE 292 K+ ++ + ++V + + L DVA ++ G + ++ R NG+ GL + + Sbjct: 237 QTRFKNPEEFGKVTLRVNSDGSVVRLKDVARVELGGENYNVIA-RINGKPAAGLGIKLAT 295 Query: 293 KGDILSLGKHLDQRIKEVQENLPAGIFIEKVVDQPSLVEHSVNEFLGHFILALGIV-LAV 351 + L K + ++ E+Q P G+ + D V+ S++E + A+ +V L + Sbjct: 296 GANALDTAKAIKAKLAELQPFFPQGMKVLYPYDTTPFVQLSIHEVVKTLFEAIMLVFLVM 355 Query: 352 SLFALGVRTGIVVALSVPLVLGITFFFMWRLDINLQRISLGALIIALGLLVDDAIIAVEM 411 LF +R ++ ++VP+VL TF + ++ +++ +++A+GLLVDDAI+ VE Sbjct: 356 YLFLQNMRATLIPTIAVPVVLLGTFAILAAFGYSINTLTMFGMVLAIGLLVDDAIVVVEN 415 Query: 412 MQ-VKMEEGLDRFKAASFAWSNTAFPMLTGTLITAAGFVPVGFALSSTSEFTGSIFWVVG 470 ++ V ME+ L +A + S ++ ++ +A F+P+ F ST + Sbjct: 416 VERVMMEDKLPPKEATEKSMSQIQGALVGIAMVLSAVFIPMAFFGGSTGAIYRQFSITIV 475 Query: 471 ISLIVSWFVAVLFTPFLGTILL-PKVQPHHSHSSK-----NSYRDKLSQWFSRKIAWCVK 524 ++ +S VA++ TP L LL P HH + N+ D ++ + + Sbjct: 476 SAMALSVLVALILTPALCATLLKPVSAEHHENKGGFFGWFNTTFDHSVNHYTNSVGKILG 535 Query: 525 KRKWVLLTTVLSFVLALVAFQFVPKQFFPDSPRAEILIDVQLEEGASYTATLNATKQVEK 584 LL L +V F +P F P+ + L +QL GA+ T QV Sbjct: 536 STGRYLLIYALIVAGMVVLFLRLPSSFLPEEDQGVFLTMIQLPAGATQERTQKVLDQVTD 595 Query: 585 LLSSDQRVRDYTAYVGSGSPRFYLSLDPETPKNNYSQLIVYPKDIEQASQLTSD-LHNRL 643 +++ + + +G S + + + + P + + +++ + +R Sbjct: 596 YYLKNEKANVESVFTVNG-----FSFSGQAQNAGMAFVSLKPWEERNGDENSAEAVIHRA 650 Query: 644 IQQFPHIR-TRVYR------LELGPTVGYPVQFRVR-GKDPEKVREIAAEVRDIMRQHP- 694 + IR V +ELG G+ + + G + + + ++ + QHP Sbjct: 651 KMELGKIRDGFVIPFNMPAIVELGTATGFDFELIDQAGLGHDALTQARNQLLGMAAQHPA 710 Query: 695 NVRDVNFQWNERSKAIRFIINQERARSLGVSSQDISRTLQMLLSGYTVTQIREGTELIDV 754 ++ V E + + ++QE+A++LGVS DI++T+ L G V + + + Sbjct: 711 SLVSVRPNGLEDTAQFKLEVDQEKAQALGVSLSDINQTISTALGGTYVNDFIDRGRVKKL 770 Query: 755 VARAKADNRLDTAQMGQITIRASNGKNIPLDQVAELRPVLEEGGIWIRNRLPTLSVRADV 814 +A A R+ + ++ +R++NG+ +P V + N LP++ ++ + Sbjct: 771 YVQADAKFRMLPEDVDKLYVRSANGEMVPFSAFTTSHWVYGSPRLERYNGLPSMEIQGEA 830 Query: 815 S-GAQAPDVSKQIEPMLNDLRKMLPIGYSIETGGTIEESAKADTAIQSVMPVMLLLWAIF 873 + G + D +E +L LP G + G + + +++ + ++ + Sbjct: 831 APGTSSGDAMALME----NLASKLPAGIGYDWTGMSYQERLSGNQAPALVAISFVVVFLC 886 Query: 874 LMLQLQSFSRMFMVVLTAPLGMIGVSLALLITRAPFGFVATLGVIALAGMIMRNSVILVD 933 L +S+S V+L PLG++GV LA + +G++ G+ +N++++V+ Sbjct: 887 LAALYESWSIPVSVMLVVPLGIVGVLLAATLFNQKNDVYFMVGLLTTIGLSAKNAILIVE 946 Query: 934 QI-DRNISTGQTPEQAIIQATVGRTRPVLLTALAAILAMIPLTLSTLWG-----PMAIAI 987 D G+ +A + A R RP+L+T+LA IL ++PL +S G + I + Sbjct: 947 FAKDLMEKEGKGVVEATLMAVRMRLRPILMTSLAFILGVLPLAISNGAGSGAQNAVGIGV 1006 Query: 988 MGGLAVATILTLFFVPALYA 1007 MGG+ AT+L +FFVP + Sbjct: 1007 MGGMVSATLLAIFFVPVFFV 1026 Score = 91.8 bits (228), Expect = 7e-21 Identities = 87/513 (16%), Positives = 197/513 (38%), Gaps = 56/513 (10%) Query: 528 WVLLTTVLSFVLALVAFQFVPKQFFPDSPRAEILIDVQLEEGASYTATLNATKQVEKLLS 587 WVL ++ + +A +P +P + + + T T+ +E+ ++ Sbjct: 13 WVL--AIILMMAGALAILQLPVAQYPTIAPPAVSVSANYPGADAQTVQDTVTQVIEQNMN 70 Query: 588 SDQRVRDYTAYVGS-GSPRFYLSLDPETPKNNYSQLIVYPKDIEQASQLTSDLHNRLIQQ 646 + ++ S GS L+ T D + A + Sbjct: 71 GIDNLMYMSSTSDSAGSVTITLTFQSGT-------------DPDIAQVQVQNKLQLATPL 117 Query: 647 FPHI--RTRVYRLELGPTVGYPVQFRVRGKD---PEKVREIAAEVRDIMRQHPNVRDVNF 701 P + + + + F + +A+ V+D + + V DV Sbjct: 118 LPQEVQQQGISVEKSSSSYLMVAGFVSDNPGTTQDDISDYVASNVKDTLSRLNGVGDVQL 177 Query: 702 QWNERSKAIRFIINQERARSLGVSSQDISRTLQ----MLLSGYTV-TQIREGTELIDVVA 756 A+R ++ + ++ D+ L+ + +G T G +L A Sbjct: 178 --FGAQYAMRIWLDADLLNKYKLTPVDVINQLKVQNDQIAAGQLGGTPALPGQQL---NA 232 Query: 757 RAKADNRLDTA-QMGQITIRAS-NGKNIPLDQVA--ELRPVLEEGGIWIRNRLPTLSVRA 812 A R + G++T+R + +G + L VA EL I + Sbjct: 233 SIIAQTRFKNPEEFGKVTLRVNSDGSVVRLKDVARVELGGENYNVIARINGKPAAGLGIK 292 Query: 813 DVSGAQAPDVSKQIEPMLNDLRKMLPIGYSIE----TGGTIEESAKADTAIQSVMPVMLL 868 +GA A D +K I+ L +L+ P G + T ++ S ++++ ++L Sbjct: 293 LATGANALDTAKAIKAKLAELQPFFPQGMKVLYPYDTTPFVQLSI--HEVVKTLFEAIML 350 Query: 869 LWAIFLMLQLQSFSRMFMVVLTAPLGMIGVSLALLITRAPFGF---VATLGVIALA-GMI 924 + + + L LQ+ + + P+ ++G + A+L A FG+ T+ + LA G++ Sbjct: 351 V-FLVMYLFLQNMRATLIPTIAVPVVLLG-TFAIL---AAFGYSINTLTMFGMVLAIGLL 405 Query: 925 MRNSVILVDQIDRNISTGQTPEQAIIQATVGRTRPVLLTALAAILAM-IPLTLST----- 978 + +++++V+ ++R + + P + + ++ + + L+ + A+ IP+ Sbjct: 406 VDDAIVVVENVERVMMEDKLPPKEATEKSMSQIQGALVGIAMVLSAVFIPMAFFGGSTGA 465 Query: 979 LWGPMAIAIMGGLAVATILTLFFVPALYAAWFR 1011 ++ +I I+ +A++ ++ L PAL A + Sbjct: 466 IYRQFSITIVSAMALSVLVALILTPALCATLLK 498
>RTXTOXIND#Gram-negative bacterial RTX secretion protein D signature. Length = 478 Score = 71.8 bits (176), Expect = 8e-16 Identities = 41/224 (18%), Positives = 80/224 (35%), Gaps = 30/224 (13%) Query: 84 IIKRLVDTGASITKNQALAQLDDTPFRLSIQEATAELHQAQSTLTRLQRDLQRNR-SLVN 142 L+ A I K+ L Q EA EL +S L +++ ++ + Sbjct: 239 DFSSLLHKQA-IAKHAVLEQ------ENKYVEAVNELRVYKSQLEQIESEILSAKEEYQL 291 Query: 143 IGAISRSDLDSLENLYQNTQAQVNAAQ--SRLDRAQNDLSYTTLRSPAVGTIAEVQAES- 199 + + ++++ L + Q N L + + + +R+P + +++ + Sbjct: 292 VTQLFKNEI-----LDKLRQTTDNIGLLTLELAKNEERQQASVIRAPVSVKVQQLKVHTE 346 Query: 200 GQVVSAGTPIFKLA-QNGENEVQIDVPESQINEIKIDQPVSIKLLSLSDHTF---TGHVR 255 G VV+ + + ++ EV V I I + Q IK+ + + G V+ Sbjct: 347 GGVVTTAETLMVIVPEDDTLEVTALVQNKDIGFINVGQNAIIKVEAFPYTRYGYLVGKVK 406 Query: 256 EIA--TVADPNSRT-YRVRISI-SNLPAAA------KLGMTATV 289 I + D + V ISI N + GM T Sbjct: 407 NINLDAIEDQRLGLVFNVIISIEENCLSTGNKNIPLSSGMAVTA 450 Score = 40.2 bits (94), Expect = 1e-05 Identities = 40/286 (13%), Positives = 84/286 (29%), Gaps = 54/286 (18%) Query: 65 SGNIVPRVESQLSFRVAGRIIKR-LVDTGASITKNQALAQLDDTPFRLSIQEATAELHQA 123 +G + S+ + I+K +V G S+ K L +L + + L QA Sbjct: 87 NGKLTHSGRSKEIKPIENSIVKEIIVKEGESVRKGDVLLKLTALGAEADTLKTQSSLLQA 146 Query: 124 QSTLTRLQ---------------------------RDLQRNRSLV--------NIGAISR 148 + TR Q ++ R SL+ N Sbjct: 147 RLEQTRYQILSRSIELNKLPELKLPDEPYFQNVSEEEVLRLTSLIKEQFSTWQNQKYQKE 206 Query: 149 SDLDSLENLYQNTQAQVNAAQSRLDRAQNDLS-YTTLRSPAVGTIAEVQAESGQVVSAGT 207 +LD A++N ++ ++ L +++L V + + V A Sbjct: 207 LNLDKKRAERLTVLARINRYENLSRVEKSRLDDFSSLLHKQAIAKHAVLEQENKYVEAV- 265 Query: 208 PIFKLAQNGENEVQIDVPESQINEIKIDQPVSIKLLSLSDHTFTGHVREIATVADPNSRT 267 + + Q++ ES+I K + L F + + N Sbjct: 266 -----NELRVYKSQLEQIESEILSAKEE-------YQLVTQLFKNEILDKLRQTTDNIGL 313 Query: 268 YRVRISISNLPAAAKLGMTATVHFLNKNVDQQIILPIGALFQKGQQ 313 + ++ + + ++ V Q + G + + Sbjct: 314 LTLELAK----NEERQQASVIRAPVSVKVQQLKVHTEGGVVTTAET 355
>RTXTOXIND#Gram-negative bacterial RTX secretion protein D signature. Length = 478 Score = 29.4 bits (66), Expect = 0.007 Identities = 4/31 (12%), Positives = 17/31 (54%) Query: 128 QRPTAGWERVLGWIYIILIPLAFVFAIVATI 158 + P + R++ + + + +AF+ +++ + Sbjct: 50 ETPVSRRPRLVAYFIMGFLVIAFILSVLGQV 80
>SACTRNSFRASE#Streptothricin acetyltransferase signature. Length = 173 Score = 32.2 bits (73), Expect = 3e-04 Identities = 20/114 (17%), Positives = 33/114 (28%), Gaps = 10/114 (8%) Query: 21 ERLYDTSPEFGDGHDAIEQLEQDLQQYTTLYTAEFNTKIIGAI-WSSGQGESKVLEYIVV 79 E + P F D + ++ + IG I S ++E I V Sbjct: 39 EERFS-KPYFKQYEDDDMDVSYVEEEGKAAFLYYLENNCIGRIKIRSNWNGYALIEDIAV 97 Query: 80 HPANRGRGVAERLVEEACRIEESKGV--------KIFEPGCGAIHRCLAHIGKL 125 R +GV L+ +A + I C + IG + Sbjct: 98 AKDYRKKGVGTALLHKAIEWAKENHFCGLMLETQDINISACHFYAKHHFIIGAV 151
>SACTRNSFRASE#Streptothricin acetyltransferase signature. Length = 173 Score = 27.6 bits (61), Expect = 0.015 Identities = 16/95 (16%), Positives = 37/95 (38%), Gaps = 3/95 (3%) Query: 32 ETDIFRKVSQQDDLFLVAIKDEQLIG--TLMGGYDGHRGWINYLAVHPHQQRLGIATALV 89 + V ++ + + IG + ++G I +AV ++ G+ TAL+ Sbjct: 53 DDMDVSYVEEEGKAAFLYYLENNCIGRIKIRSNWNG-YALIEDIAVAKDYRKKGVGTALL 111 Query: 90 QQLEKRLIARGCPKLQLLVRKDNLNVLNFYEQLGY 124 + + L L + N++ +FY + + Sbjct: 112 HKAIEWAKENHFCGLMLETQDINISACHFYAKHHF 146
>PF06580#Sensor histidine kinase Length = 349 Score = 40.2 bits (94), Expect = 1e-05 Identities = 23/129 (17%), Positives = 46/129 (35%), Gaps = 33/129 (25%) Query: 340 LDIQFEMQDVPIIPARSLSLKRLIANLINNAKRYGAEP------IDLSAKVENENILITV 393 I + DV + P L+ L+ N ++G I L +N + + V Sbjct: 244 NQINPAIMDVQVPPM-------LVQTLVENGIKHGIAQLPQGGKILLKGTKDNGTVTLEV 296 Query: 394 ADHGEGIPPDQIEELMQPFVRGDAARTIQGSGLGLAIVKRIVDIHHGE---IQIHNREQG 450 + G + E +G GL V+ + + +G I++ +QG Sbjct: 297 ENTGSLALKNTKE----------------STGTGLQNVRERLQMLYGTEAQIKLSE-KQG 339 Query: 451 GLEVIISLP 459 + ++ +P Sbjct: 340 KVNAMVLIP 348
>HTHFIS#FIS bacterial regulatory protein HTH signature. Length = 484 Score = 101 bits (252), Expect = 1e-26 Identities = 40/136 (29%), Positives = 73/136 (53%), Gaps = 3/136 (2%) Query: 22 RILVVDDDVRLRTLLQRFLEDKGFVVKTAHDASQMDRLLQRELFSLIVLDFMLPVEDGLS 81 ILV DDD +RT+L + L G+ V+ +A+ + R + L+V D ++P E+ Sbjct: 5 TILVADDDAAIRTVLNQALSRAGYDVRITSNAATLWRWIAAGDGDLVVTDVVMPDENAFD 64 Query: 82 ICRRLRQSNIDTPIIMLTARGSDSDRIAGLEAGADDYLPKPFNPNELLARIRAVL---RR 138 + R++++ D P+++++A+ + I E GA DYLPKPF+ EL+ I L +R Sbjct: 65 LLPRIKKARPDLPVLVMSAQNTFMTAIKASEKGAYDYLPKPFDLTELIGIIGRALAEPKR 124 Query: 139 QVREVPGAPSQQVEVV 154 + ++ + +V Sbjct: 125 RPSKLEDDSQDGMPLV 140
>DHBDHDRGNASE#2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase signature. Length = 261 Score = 95.1 bits (236), Expect = 3e-25 Identities = 55/177 (31%), Positives = 91/177 (51%), Gaps = 2/177 (1%) Query: 13 VQDKVILVTGASSGIGLTISNKLADAGAHVLLVARTKETLEEVKADIESRGGKASIFPCD 72 ++ K+ +TGA+ GIG ++ LA GAH+ V E LE+V + +++ A FP D Sbjct: 6 IEGKIAFITGAAQGIGEAVARTLASQGAHIAAVDYNPEKLEKVVSSLKAEARHAEAFPAD 65 Query: 73 LNDMDMIDQVSKEILATVDHIDILINNAGRSIRRAVHESYDRFHDFERTMQLNYFGAVRL 132 + D ID+++ I + IDIL+N AG +H D ++E T +N G Sbjct: 66 VRDSAAIDEITARIEREMGPIDILVNVAGVLRPGLIHSLSD--EEWEATFSVNSTGVFNA 123 Query: 133 VLNILPHMIQRKDGQIINISSIGVLANATRFSAYVASKAALDAFSRCLSAEVHAHKI 189 ++ +M+ R+ G I+ + S T +AY +SKAA F++CL E+ + I Sbjct: 124 SRSVSKYMMDRRSGSIVTVGSNPAGVPRTSMAAYASSKAAAVMFTKCLGLELAEYNI 180
>SECA#SecA protein signature. Length = 901 Score = 1216 bits (3147), Expect = 0.0 Identities = 530/909 (58%), Positives = 679/909 (74%), Gaps = 12/909 (1%) Query: 1 MLASLIGGIFGTKNERELKRMRKIVEQINALEPTISALSDADLSAKTPEFKQRYNNGESL 60 ML L+ +FG++N+R L+RMRK+V INA+EP + LSD +L KT EF+ R GE L Sbjct: 1 MLIKLLTKVFGSRNDRTLRRMRKVVNIINAMEPEMEKLSDEELKGKTAEFRARLEKGEVL 60 Query: 61 DKLLPEAFAVCREAAKRVMGMRHYDVQLIGGITLHEGKIAEMRTGEGKTLMGTLACYLNA 120 + L+PEAFAV REA+KRV GMRH+DVQL+GG+ L+E IAEMRTGEGKTL TL YLNA Sbjct: 61 ENLIPEAFAVVREASKRVFGMRHFDVQLLGGMVLNERCIAEMRTGEGKTLTATLPAYLNA 120 Query: 121 LSGEGVHVITVNDYLAQRDAELNRPLFEFLGLSIGTIYSMQGPSEKAEAYLADITYGTNN 180 L+G+GVHV+TVNDYLAQRDAE NRPLFEFLGL++G K EAY ADITYGTNN Sbjct: 121 LTGKGVHVVTVNDYLAQRDAENNRPLFEFLGLTVGINLPGMPAPAKREAYAADITYGTNN 180 Query: 181 EFGFDYLRDNMVFSLAEKKQRGLHYAIIDEVDSILIDEARTPLIISGQSEDSSHLYSAIN 240 E+GFDYLRDNM FS E+ QR LHYA++DEVDSILIDEARTPLIISG +EDSS +Y +N Sbjct: 181 EYGFDYLRDNMAFSPEERVQRKLHYALVDEVDSILIDEARTPLIISGPAEDSSEMYKRVN 240 Query: 241 TIPPKLHPQK---EEKVADGGHFWIDEKQRSVEMTEIGYETVEQELIQMGLLAEGESLYS 297 I P L Q+ E GHF +DEK R V +TE G +E+ L++ G++ EGESLYS Sbjct: 241 KIIPHLIRQEKEDSETFQGEGHFSVDEKSRQVNLTERGLVLIEELLVKEGIMDEGESLYS 300 Query: 298 ATNLSLVHHVSAAIRAHFLFQRDVHYIIHDGEVVIVDEHTGRTMPGRRWSEGLHQAVEAK 357 N+ L+HHV+AA+RAH LF RDV YI+ DGEV+IVDEHTGRTM GRRWS+GLHQAVEAK Sbjct: 301 PANIMLMHHVTAALRAHALFTRDVDYIVKDGEVIIVDEHTGRTMQGRRWSDGLHQAVEAK 360 Query: 358 EGLEIQPENQTLATTTFQNYFRLYKKLSGMTGTADTEAAEMKEIYGLDVVIIPTHRPMVR 417 EG++IQ ENQTLA+ TFQNYFRLY+KL+GMTGTADTEA E IY LD V++PT+RPM+R Sbjct: 361 EGVQIQNENQTLASITFQNYFRLYEKLAGMTGTADTEAFEFSSIYKLDTVVVPTNRPMIR 420 Query: 418 NDQNDLIYLNRNGKYDAIIQEITNIREQGVAPILIGTATIEASEILSSKLMQAGIHHEVL 477 D DL+Y+ K AII++I +G P+L+GT +IE SE++S++L +AGI H VL Sbjct: 421 KDLPDLVYMTEAEKIQAIIEDIKERTAKG-QPVLVGTISIEKSELVSNELTKAGIKHNVL 479 Query: 478 NAKQHEREADIIAQAGSPNAVTIATNMAGRGTDIILGGNWKAKLAKLENPTAEDEARLKA 537 NAK H EA I+AQAG P AVTIATNMAGRGTDI+LGG+W+A++A LENPTAE ++KA Sbjct: 480 NAKFHANEAAIVAQAGYPAAVTIATNMAGRGTDIVLGGSWQAEVAALENPTAEQIEKIKA 539 Query: 538 QWEQDHEDVLKSGGLHIIGSERHESRRIDNQLRGRAGRQGDPGVSRFYLSLEDDLMRIFA 597 W+ H+ VL++GGLHIIG+ERHESRRIDNQLRGR+GRQGD G SRFYLS+ED LMRIFA Sbjct: 540 DWQVRHDAVLEAGGLHIIGTERHESRRIDNQLRGRSGRQGDAGSSRFYLSMEDALMRIFA 599 Query: 598 GDRVVGMMRAMGLQENEAIEHKMVSRSIENAQRKVEARNFDIRKNLLKYDDVNNEQRKII 657 DRV GMMR +G++ EAIEH V+++I NAQRKVE+RNFDIRK LL+YDDV N+QR+ I Sbjct: 600 SDRVSGMMRKLGMKPGEAIEHPWVTKAIANAQRKVESRNFDIRKQLLEYDDVANDQRRAI 659 Query: 658 YSQRDEVLAENTLKEYVEEMHHEVMKGVIANFIPPESIHDQWDVEGLENALRIDLGIELP 717 YSQR+E+L + + E + + +V K I +IPP+S+ + WD+ GL+ L+ D ++LP Sbjct: 660 YSQRNELLDVSDVSETINSIREDVFKATIDAYIPPQSLEEMWDIPGLQERLKNDFDLDLP 719 Query: 718 IQEWLDQDRRLDEEGLVERISDEVIERYRQRRAQMGDESAAMLERHFVLNSLDRHWKDHL 777 I EWLD++ L EE L ERI + IE Y+++ +G E E+ +L +LD WK+HL Sbjct: 720 IAEWLDKEPELHEETLRERILAQSIEVYQRKEEVVGAEMMRHFEKGVMLQTLDSLWKEHL 779 Query: 778 AAMDYLRQGIHLRGYAQKNPEQEYKKEAFNLFVNMLGIIKTDVVTDLSRVHIPTPEELAE 837 AAMDYLRQGIHLRGYAQK+P+QEYK+E+F++F ML +K +V++ LS+V + PEE+ E Sbjct: 780 AAMDYLRQGIHLRGYAQKDPKQEYKRESFSMFAAMLESLKYEVISTLSKVQVRMPEEVEE 839 Query: 838 MEAQQQQQAESMKLSFEHDDVDGLTGEVTLSQESVNESNDQQAFPVPESRNAPCPCGSGL 897 +E Q++ +AE + + + + + ++ +++ RN PCPCGSG Sbjct: 840 LEQQRRMEAERLA---QMQQLSHQDDDSAAAAALAAQTGERKV-----GRNDPCPCGSGK 891 Query: 898 KYKQCHGKI 906 KYKQCHG++ Sbjct: 892 KYKQCHGRL 900
>TCRTETA#Tetracycline resistance protein signature. Length = 399 Score = 32.9 bits (75), Expect = 0.002 Identities = 70/375 (18%), Positives = 133/375 (35%), Gaps = 48/375 (12%) Query: 64 LATFAIA-FIARPIGAAIFGHLGDRIGRKATLVAALLTMGISTVCIGLLPTYAHIGIFAP 122 LA +A+ F P+ G L DR GR+ L+ +L + + P Sbjct: 49 LALYALMQFACAPVL----GALSDRFGRRPVLLVSLAGAAVDYAIMATAPFLW------- 97 Query: 123 LLLAVCRLGQGLGLGGEWSGAVLLATENAPEGKRA-WYGMFPQLGAPIGFILATGSFLLL 181 +L + R+ G+ G + A + +RA +G + A GF + G L Sbjct: 98 -VLYIGRIVAGIT-GATGAVAGAYIADITDGDERARHFGF---MSACFGFGMVAGPVL-- 150 Query: 182 SATIPEQAFM-QWGWRIPFIASAVLVIVG-LYIRLKLHETPAFQKVLDKQKEVN----IP 235 M + PF A+A L + L L E+ ++ +++ +N Sbjct: 151 ------GGLMGGFSPHAPFFAAAALNGLNFLTGCFLLPESHKGERRPLRREALNPLASFR 204 Query: 236 FKEVITKHTGKLILGTIAAICTFV---VFYLTTVFALNWGTTKLGYARGEFLELQLFATL 292 + +T + + I + V ++ + +W T +G + L F L Sbjct: 205 WARGMTVVAALMAVFFIMQLVGQVPAALWVIFGEDRFHWDATTIGIS------LAAFGIL 258 Query: 293 CFAAFIPLSAIFAEKFGRKTTSIGVCIAAAIFGLFFSSMLESG-NTLIVFLFLCTGLAIM 351 A ++ A + G + + + + A G + G + + L +G M Sbjct: 259 HSLAQAMITGPVAARLGERRA-LMLGMIADGTGYILLAFATRGWMAFPIMVLLASGGIGM 317 Query: 352 GLTYGPIGTVLSELFPTSVRYTGSALTFNLAGIFGASFAPLIATKLAETYGLYAVGYYLT 411 + + E ++ + +ALT +L I G PL+ T + G+ Sbjct: 318 PALQAMLSRQVDEERQGQLQGSLAALT-SLTSIVG----PLLFTAIYAASITTWNGWAWI 372 Query: 412 AASLLSLIAFLLIRE 426 A + L L+ +R Sbjct: 373 AGAALYLLCLPALRR 387
>SACTRNSFRASE#Streptothricin acetyltransferase signature. Length = 173 Score = 36.1 bits (83), Expect = 1e-05 Identities = 16/60 (26%), Positives = 27/60 (45%), Gaps = 3/60 (5%) Query: 65 SVGRVAVLVPYRKQGIGKILMQHIIDYARRHKLSYLKLSAQTYVTA---FYEALGFHVQG 121 + +AV YRK+G+G L+ I++A+ + L L Q + FY F + Sbjct: 91 LIEDIAVAKDYRKKGVGTALLHKAIEWAKENHFCGLMLETQDINISACHFYAKHHFIIGA 150
>PF06580#Sensor histidine kinase Length = 349 Score = 26.8 bits (59), Expect = 0.009 Identities = 9/51 (17%), Positives = 17/51 (33%), Gaps = 7/51 (13%) Query: 11 VLGWKF--VLIVGVLSAIFLGFFYLAMSNEPDYMPGAQRKAQQEQMQQKAE 59 L F V++ + S Y +Y + + M Q+A+ Sbjct: 117 ALSIIFNVVVVTFMWSL-----LYFGWHFFKNYKQAEIDQWKMASMAQEAQ 162
>ACRIFLAVINRP#Acriflavin resistance protein family signature. Length = 1034 Score = 788 bits (2037), Expect = 0.0 Identities = 286/1037 (27%), Positives = 493/1037 (47%), Gaps = 34/1037 (3%) Query: 5 RISVKYPVFTIMMMISLMVLGLASWKRMTVEEFPNVDFPFVVVTTQYAGASPEAVESDIT 64 ++ P+F ++ I LM+ G + ++ V ++P + P V V+ Y GA + V+ +T Sbjct: 3 NFFIRRPIFAWVLAIILMMAGALAILQLPVAQYPTIAPPAVSVSANYPGADAQTVQDTVT 62 Query: 65 KKLEDQINTISGIKQITSRS-SEGFSMIVAEFNLDTSSALAAQDVRDKIAPVTAQFRDEI 123 + +E +N I + ++S S S G I F T +A V++K+ T E+ Sbjct: 63 QVIEQNMNGIDNLMYMSSTSDSAGSVTITLTFQSGTDPDIAQVQVQNKLQLATPLLPQEV 122 Query: 124 DTPIVQRYDPSSSPIMSVVFESSSMSLAQ--LSSYVDKRIVPQLKTVSGVGNVNLLGDAK 181 + SSS +M F S + Q +S YV + L ++GVG+V L G A+ Sbjct: 123 QQQGISVEKSSSSYLMVAGFVSDNPGTTQDDISDYVASNVKDTLSRLNGVGDVQLFG-AQ 181 Query: 182 RQIRIKILPEQLQSYGIGIDQVINTLKNENIEVPAGTL------QQKNSELVVQIQSKVI 235 +RI + + L Y + VIN LK +N ++ AG L + + Q++ Sbjct: 182 YAMRIWLDADLLNKYKLTPVDVINQLKVQNDQIAAGQLGGTPALPGQQLNASIIAQTRFK 241 Query: 236 HPLAFGDLVI-ANKNSSPIFLKQVATIEDTQAELQSSAFYNGRTAVSVDILKSSDANVIQ 294 +P FG + + N + S + LK VA +E A NG+ A + I ++ AN + Sbjct: 242 NPEEFGKVTLRVNSDGSVVRLKDVARVELGGENYNVIARINGKPAAGLGIKLATGANALD 301 Query: 295 VVDKTYQTLEKLKTQMPAGLNYKVVADSSKGIRASIKDVTRTIIEGAALAVLIVLLFLGS 354 L +L+ P G+ D++ ++ SI +V +T+ E L L++ LFL + Sbjct: 302 TAKAIKAKLAELQPFFPQGMKVLYPYDTTPFVQLSIHEVVKTLFEAIMLVFLVMYLFLQN 361 Query: 355 FRSTVITGLTLPITLLGTLTFIWAFGFSINMMTLLALSLSIGLLIDDAIVVRENIVRH-T 413 R+T+I + +P+ LLGT + AFG+SIN +T+ + L+IGLL+DDAIVV EN+ R Sbjct: 362 MRATLIPTIAVPVVLLGTFAILAAFGYSINTLTMFGMVLAIGLLVDDAIVVVENVERVMM 421 Query: 414 ELGKDHVTAALEGTKEIGLAVLATTLTIVAVFLPVAFMGGLIGRFFYQFGVTVSTAVLIS 473 E A + +I A++ + + AVF+P+AF GG G + QF +T+ +A+ +S Sbjct: 422 EDKLPPKEATEKSMSQIQGALVGIAMVLSAVFIPMAFFGGSTGAIYRQFSITIVSAMALS 481 Query: 474 MFISFTLDPMLSAHWKDPVKKKD-NWLQRFFNHISNVLDRLTHVYEKLLKLALRFRFITV 532 + ++ L P L A PV + FF + D + Y + L + Sbjct: 482 VLVALILTPALCATLLKPVSAEHHENKGGFFGWFNTTFDHSVNHYTNSVGKILGSTGRYL 541 Query: 533 IIAIVSLFAALGLSKLIGTEFVPTPDKGEVRIQFETPVDASLEYTQAKLHQVDKII--RQ 590 +I + + + L + + F+P D+G + P A+ E TQ L QV + Sbjct: 542 LIYALIVAGMVVLFLRLPSSFLPEEDQGVFLTMIQLPAGATQERTQKVLDQVTDYYLKNE 601 Query: 591 FPDVVSTYGVVNSEVDSGKNHAGLG-VTLKPKQERSSDLNTLNNEFRDRLQSVAGIRVTS 649 +V S + V +AG+ V+LKP +ER+ D N+ + IR Sbjct: 602 KANVESVFTVNGFSFSGQAQNAGMAFVSLKPWEERNGDENSAEAVIHRAKMELGKIRDGF 661 Query: 650 VAAAQDS------VSGGQKPIMISIKGSDLNELQKISDRFIAEMEK-IKGVVDLESSLKE 702 V + G +I G + L + ++ + + +V + + E Sbjct: 662 VIPFNMPAIVELGTATGFDFELIDQAGLGHDALTQARNQLLGMAAQHPASLVSVRPNGLE 721 Query: 703 PKPTLGVHINRVLASDLGLSVSQIANAIRPLIAGDNVTTWEDRDGENYDVNVRLNENKRM 762 + +++ A LG+S+S I I + G V + D G + V+ + RM Sbjct: 722 DTAQFKLEVDQEKAQALGVSLSDINQTISTALGGTYVNDFID-RGRVKKLYVQADAKFRM 780 Query: 763 LPQDVQNLYLNSNKTNATGQNILVPLSAVATTEEKLGASQINRRDLEREVLIEAN-TSGR 821 LP+DV LY+ +A G+ +VP SA T+ G+ ++ R + + I+ G Sbjct: 781 LPEDVDKLYV----RSANGE--MVPFSAFTTSHWVYGSPRLERYNGLPSMEIQGEAAPGT 834 Query: 822 PSGDIGQDIDKMQKVFKLPAGYTFDTQGANADMAESAGYALTAITLSIVFIYIVLGSQFN 881 SGD ++ + KLPAG +D G + S A + +S V +++ L + + Sbjct: 835 SSGDAMALMENLAS--KLPAGIGYDWTGMSYQERLSGNQAPALVAISFVVVFLCLAALYE 892 Query: 882 SFIHPAAIMTSLPLSLIGVFLALFLFKSTLNLFSIIGIIMLMGLVTKNAILLIDFIKKAM 941 S+ P ++M +PL ++GV LA LF +++ ++G++ +GL KNAIL+++F K M Sbjct: 893 SWSIPVSVMLVVPLGIVGVLLAATLFNQKNDVYFMVGLLTTIGLSAKNAILIVEFAKDLM 952 Query: 942 D-QGTSRYDAILQAGKTRLRPILMTTSAMVMGMVPLALGLGEGGEQSAPMAHAVIGGVIT 1000 + +G +A L A + RLRPILMT+ A ++G++PLA+ G G + V+GG+++ Sbjct: 953 EKEGKGVVEATLMAVRMRLRPILMTSLAFILGVLPLAISNGAGSGAQNAVGIGVMGGMVS 1012 Query: 1001 STLLTLVVVPVIFTYLD 1017 +TLL + VPV F + Sbjct: 1013 ATLLAIFFVPVFFVVIR 1029
>HTHFIS#FIS bacterial regulatory protein HTH signature. Length = 484 Score = 83.0 bits (205), Expect = 2e-18 Identities = 28/124 (22%), Positives = 55/124 (44%), Gaps = 2/124 (1%) Query: 1377 IMIVDDSVTVRKVTTRLLERQGYDVVTAKDGIDAIEQLENIKPDLMLLDIEMPRMDGFEV 1436 I++ DD +R V + L R GYDV + + DL++ D+ MP + F++ Sbjct: 6 ILVADDDAAIRTVLNQALSRAGYDVRITSNAATLWRWIAAGDGDLVVTDVVMPDENAFDL 65 Query: 1437 LNLVRHHDLHQHMPVIMITSRTGEKHRERAFALGVNQYMGKPFQEEDLLHNIDAFFTTRE 1496 L ++ +PV++++++ +A G Y+ KPF +L+ I + Sbjct: 66 LPRIKKAR--PDLPVLVMSAQNTFMTAIKASEKGAYDYLPKPFDLTELIGIIGRALAEPK 123 Query: 1497 EELA 1500 + Sbjct: 124 RRPS 127
>TCRTETA#Tetracycline resistance protein signature. Length = 399 Score = 29.0 bits (65), Expect = 0.035 Identities = 43/216 (19%), Positives = 77/216 (35%), Gaps = 19/216 (8%) Query: 106 LFAFFISLLLMNLTGATQDIATDALAVNLLKHDQQHWGNTFQVIGSRLGF-IVGGGAVLW 164 L+ +I ++ +TGAT +A +A ++ F + + GF +V G + Sbjct: 96 LWVLYIGRIVAGITGATGAVAGAYIADITDGDERARH---FGFMSACFGFGMVAGPVLGG 152 Query: 165 CLDWLTWQPTFLLLAALVFLNTLPVLLFKEPKHAVYSGHQLKPSQQNLVIKIKAYLSYFS 224 + + F AAL LN L H K ++ L + L+ F Sbjct: 153 LMGGFSPHAPFFAAAALNGLNFLTGCFLLPESH--------KGERRPLRREALNPLASFR 204 Query: 225 QNKELRSWLVVLITFKVAD--GLAGPLLKPLMVD--MGLSFTQIGVYITMLGAVAALAGA 280 + + ++ F + G L + + T IG+ + G + +LA A Sbjct: 205 WARGMTVVAALMAVFFIMQLVGQVPAALWVIFGEDRFHWDATTIGISLAAFGILHSLAQA 264 Query: 281 AIAGGVLKYFSRPTTLIIFSVFKIMSLAAYAYLAYA 316 I G V ++ + I Y LA+A Sbjct: 265 MITGPVAARLGE-RRALMLGM--IADGTGYILLAFA 297
>56KDTSANTIGN#Rickettsia 56kDa type-specific antigen protein signature. Length = 533 Score = 34.9 bits (80), Expect = 5e-04 Identities = 12/32 (37%), Positives = 14/32 (43%) Query: 51 IQQQSQVQQQQQQVQQQQQVQLAEVKAQPVAA 82 I + Q QQ Q Q Q Q A+ AQ A Sbjct: 330 IHLNFVMPPQAQQQQGQGQQQQAQATAQEAVA 361 Score = 30.7 bits (69), Expect = 0.014 Identities = 12/30 (40%), Positives = 13/30 (43%) Query: 53 QQSQVQQQQQQVQQQQQVQLAEVKAQPVAA 82 QQQQ QQQQ Q +A AA Sbjct: 335 VMPPQAQQQQGQGQQQQAQATAQEAVAAAA 364 Score = 30.3 bits (68), Expect = 0.016 Identities = 18/43 (41%), Positives = 21/43 (48%), Gaps = 4/43 (9%) Query: 47 LKALIQQQSQVQQQQQQVQQQQQVQLAEVKAQPVAAPVSPLAG 89 L ++ Q+Q QQ Q Q QQQ Q E A AA V L G Sbjct: 332 LNFVMPPQAQQQQGQGQ-QQQAQATAQEAVA---AAAVRLLNG 370
>HTHFIS#FIS bacterial regulatory protein HTH signature. Length = 484 Score = 77.9 bits (192), Expect = 7e-19 Identities = 33/139 (23%), Positives = 63/139 (45%), Gaps = 3/139 (2%) Query: 2 TKILMIEDDFMIAESTITLLQYHQFEVEWVNNGLDGLAQLAKNKFDIILLDLGLPMMDGM 61 IL+ +DD I L ++V +N +A D+++ D+ +P + Sbjct: 4 ATILVADDDAAIRTVLNQALSRAGYDVRITSNAATLWRWIAAGDGDLVVTDVVMPDENAF 63 Query: 62 QVLKQIRQR-AVTPVLIISARDQLQNRVDGLNHGADDYLIKPYEFDELLARIHALLRRTG 120 +L +I++ PVL++SA++ + GA DYL KP++ EL+ I L Sbjct: 64 DLLPRIKKARPDLPVLVMSAQNTFMTAIKASEKGAYDYLPKPFDLTELIGIIGRALAEP- 122 Query: 121 VEAQLANHEQLLQNGDLVL 139 + + + E Q+G ++ Sbjct: 123 -KRRPSKLEDDSQDGMPLV 140
>PF05272#Virulence-associated E family protein Length = 892 Score = 30.4 bits (68), Expect = 0.014 Identities = 18/76 (23%), Positives = 31/76 (40%), Gaps = 5/76 (6%) Query: 111 GGIAERAKMRSQAIATLALVALVYP---FFEGMVWNGNYGLQKWLEATFGAAFHDFAGSV 167 G A+ QAI A + V+P + + W+ L+KWL G D+ Sbjct: 510 GTGEASAQTTEQAINVAADMNRVHPFRDWVKAQQWDEVPRLEKWLVHVLGKTPDDYKPRR 569 Query: 168 V--VHAMGGWIALAAV 181 + + +G +I + V Sbjct: 570 LRYLQLVGKYILMGHV 585
>DHBDHDRGNASE#2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase signature. Length = 261 Score = 90.9 bits (225), Expect = 6e-24 Identities = 55/189 (29%), Positives = 99/189 (52%), Gaps = 1/189 (0%) Query: 7 LQNKVVWITGASSGLGKALAGELALQGAEVILTSRRFEELEEVRVGLLNADRHVSVV-AD 65 ++ K+ +ITGA+ G+G+A+A LA QGA + E+LE+V L RH AD Sbjct: 6 IEGKIAFITGAAQGIGEAVARTLASQGAHIAAVDYNPEKLEKVVSSLKAEARHAEAFPAD 65 Query: 66 ITDEKQVNEAYKQILKAKGRIDWLINNAGLSQRALIKDTTMATERAIMEVDYFSQVALTK 125 + D ++E +I + G ID L+N AG+ + LI + A V+ ++ Sbjct: 66 VRDSAAIDEITARIEREMGPIDILVNVAGVLRPGLIHSLSDEEWEATFSVNSTGVFNASR 125 Query: 126 TVLPTMLKQKSGRVVFVSSVAGLLGTQYRASYSAAKAAIHMWANSLRAEVSDQGVEVSVI 185 +V M+ ++SG +V V S + A+Y+++KAA M+ L E+++ + +++ Sbjct: 126 SVSKYMMDRRSGSIVTVGSNPAGVPRTSMAAYASSKAAAVMFTKCLGLELAEYNIRCNIV 185 Query: 186 FPGFVKTNV 194 PG +T++ Sbjct: 186 SPGSTETDM 194
>RTXTOXIND#Gram-negative bacterial RTX secretion protein D signature. Length = 478 Score = 30.2 bits (68), Expect = 0.023 Identities = 24/166 (14%), Positives = 53/166 (31%), Gaps = 28/166 (16%) Query: 79 DLRTATLNIERAQQQYRITQNNQLPTIGASGSAIRQVSQSRDPNNPYSTYQVGLGVTAYE 138 L A L R Q R + N+LP + Q + Sbjct: 142 SLLQARLEQTRYQILSRSIELNKLPELKLPDEPYFQNVSEEEVL---------------- 185 Query: 139 LDFWGRVRSLKDAALDSYLSTQSARDSTQISLISQVAQAWLNYSFATANLRLAEQTLKAQ 198 R+ SL ++ Q+ + +++L + A+ A + E + + Sbjct: 186 -----RLTSLIKEQFSTW---QNQKYQKELNLDKKRAER----LTVLARINRYENLSRVE 233 Query: 199 QDSYNLNKKRFDVGIDSEVPLRQAQISVETARNDVANYKTQIAQAQ 244 + + ++ + + + A N++ YK+Q+ Q + Sbjct: 234 KSRLDDFSSLLHKQAIAKHAVLEQENKYVEAVNELRVYKSQLEQIE 279
>ACRIFLAVINRP#Acriflavin resistance protein family signature. Length = 1034 Score = 1187 bits (3073), Expect = 0.0 Identities = 606/1048 (57%), Positives = 783/1048 (74%), Gaps = 18/1048 (1%) Query: 1 MAQFFIHRPIFAWVIALVIMLAGILTLTKMPIAQYPTIAPPTVTIAATYPGASAETVENT 60 MA FFI RPIFAWV+A+++M+AG L + ++P+AQYPTIAPP V+++A YPGA A+TV++T Sbjct: 1 MANFFIRRPIFAWVLAIILMMAGALAILQLPVAQYPTIAPPAVSVSANYPGADAQTVQDT 60 Query: 61 VTQIIEQQMNGLDGLRYISSNSAGNGQASIQLNFEQGIDPDIAQVQVQNKLQSATALLPE 120 VTQ+IEQ MNG+D L Y+SS S G +I L F+ G DPDIAQVQVQNKLQ AT LLP+ Sbjct: 61 VTQVIEQNMNGIDNLMYMSSTSDSAGSVTITLTFQSGTDPDIAQVQVQNKLQLATPLLPQ 120 Query: 121 DVQRQGVTVTKSGASFLQVIAFYSPDNTLSDSDIKDYVNSSIKEPLSRVAGVGEVQVFGG 180 +VQ+QG++V KS +S+L V F S + + DI DYV S++K+ LSR+ GVG+VQ+FG Sbjct: 121 EVQQQGISVEKSSSSYLMVAGFVSDNPGTTQDDISDYVASNVKDTLSRLNGVGDVQLFGA 180 Query: 181 SYAMRIWLDPAKLTNYQLTPSDIATALQAQNSQVAVGQLGGAPAVQGQVLNATVNAQSLL 240 YAMRIWLD L Y+LTP D+ L+ QN Q+A GQLGG PA+ GQ LNA++ AQ+ Sbjct: 181 QYAMRIWLDADLLNKYKLTPVDVINQLKVQNDQIAAGQLGGTPALPGQQLNASIIAQTRF 240 Query: 241 QTPEQFKNIFLKNTASGAEVRLKDVARVELGSDNYQFDSKFNGKPAGGLAIKIATGANAL 300 + PE+F + L+ + G+ VRLKDVARVELG +NY ++ NGKPA GL IK+ATGANAL Sbjct: 241 KNPEEFGKVTLRVNSDGSVVRLKDVARVELGGENYNVIARINGKPAAGLGIKLATGANAL 300 Query: 301 DTADAVEHRLAELRKNYPTGLADKLAYDTTPFIRLSIESVVHTLIEAVILVFIVMFLFLQ 360 DTA A++ +LAEL+ +P G+ YDTTPF++LSI VV TL EA++LVF+VM+LFLQ Sbjct: 301 DTAKAIKAKLAELQPFFPQGMKVLYPYDTTPFVQLSIHEVVKTLFEAIMLVFLVMYLFLQ 360 Query: 361 NWRATIIPTLAVPVVVLGTFAVINIFGFSINTLTMFAMVLAIGLLVDDAIVVVENVERVM 420 N RAT+IPT+AVPVV+LGTFA++ FG+SINTLTMF MVLAIGLLVDDAIVVVENVERVM Sbjct: 361 NMRATLIPTIAVPVVLLGTFAILAAFGYSINTLTMFGMVLAIGLLVDDAIVVVENVERVM 420 Query: 421 SEEHTDPVTATSRSMQQISGALIGITSVLTAVFVPMAFFGGTTGVIYRQFSITLVTAMVL 480 E+ P AT +SM QI GAL+GI VL+AVF+PMAFFGG+TG IYRQFSIT+V+AM L Sbjct: 421 MEDKLPPKEATEKSMSQIQGALVGIAMVLSAVFIPMAFFGGSTGAIYRQFSITIVSAMAL 480 Query: 481 SLIVALTFTPALCATILKQHDPNKEPSNNIFARFFRGFNNGFDRMSHSYQNGVSRMLKGK 540 S++VAL TPALCAT+LK P + FF FN FD + Y N V ++L Sbjct: 481 SVLVALILTPALCATLLK---PVSAEHHENKGGFFGWFNTTFDHSVNHYTNSVGKILGST 537 Query: 541 IFSGVLYAVVIGLLVFLFQKLPSSFLPEEDQGVVMTLVQLPPNATLDRTGKVIDTMTNFF 600 ++YA+++ +V LF +LPSSFLPEEDQGV +T++QLP AT +RT KV+D +T+++ Sbjct: 538 GRYLLIYALIVAGMVVLFLRLPSSFLPEEDQGVFLTMIQLPAGATQERTQKVLDQVTDYY 597 Query: 601 M-NEKDTVESIFTVSGFSFTGVGQNAGIGFVKLKDWSERTSPESQIGALIQRGMALNMIV 659 + NEK VES+FTV+GFSF+G QNAG+ FV LK W ER E+ A+I R + Sbjct: 598 LKNEKANVESVFTVNGFSFSGQAQNAGMAFVSLKPWEERNGDENSAEAVIHRAKMELGKI 657 Query: 660 KDASYIMPLQLPAMPELGVTAGFNLQLKDSSGQGHEKLIAARNTILGLASQD-KRLVGVR 718 +D +++P +PA+ ELG GF+ +L D +G GH+ L ARN +LG+A+Q LV VR Sbjct: 658 RDG-FVIPFNMPAIVELGTATGFDFELIDQAGLGHDALTQARNQLLGMAAQHPASLVSVR 716 Query: 719 PNGQEDTPQYQINVDQAQAGAMGVSIADINNTMRIAWGGSYINDFVDRGRVKKVYVQGDS 778 PNG EDT Q+++ VDQ +A A+GVS++DIN T+ A GG+Y+NDF+DRGRVKK+YVQ D+ Sbjct: 717 PNGLEDTAQFKLEVDQEKAQALGVSLSDINQTISTALGGTYVNDFIDRGRVKKLYVQADA 776 Query: 779 DSRMMPEDLNKWYVRNSKGEMVPFSAFATGKWTYGSPRLERYNGVSSVNIQGTPAPGVSS 838 RM+PED++K YVR++ GEMVPFSAF T W YGSPRLERYNG+ S+ IQG APG SS Sbjct: 777 KFRMLPEDVDKLYVRSANGEMVPFSAFTTSHWVYGSPRLERYNGLPSMEIQGEAAPGTSS 836 Query: 839 GDSMKAMEEIIAKLPSMGLQGFDYEWTGLSLEERESGAQAPFLYALSLLIVFLCLAALYE 898 GD+M ME + +KLP G Y+WTG+S +ER SG QAP L A+S ++VFLCLAALYE Sbjct: 837 GDAMALMENLASKLP----AGIGYDWTGMSYQERLSGNQAPALVAISFVVVFLCLAALYE 892 Query: 899 SWSIPFSVLLVVPLGIIGAIVLTYLGMIIKGDPNLSNNIYFQVAMIAVIGLSAKNAILIV 958 SWSIP SV+LVVPLGI+G ++ L N N++YF V ++ IGLSAKNAILIV Sbjct: 893 SWSIPVSVMLVVPLGIVGVLLAATLF-------NQKNDVYFMVGLLTTIGLSAKNAILIV 945 Query: 959 EFAKELQEK-GEDLLEATLHASKMRLRPIIMTTLAFGFGVLPLALSTGAGAGSQHSVGFG 1017 EFAK+L EK G+ ++EATL A +MRLRPI+MT+LAF GVLPLA+S GAG+G+Q++VG G Sbjct: 946 EFAKDLMEKEGKGVVEATLMAVRMRLRPILMTSLAFILGVLPLAISNGAGSGAQNAVGIG 1005 Query: 1018 VLGGVLSATFLGIFFIPVFYVWIRSIFK 1045 V+GG++SAT L IFF+PVF+V IR FK Sbjct: 1006 VMGGMVSATLLAIFFVPVFFVVIRRCFK 1033
>RTXTOXIND#Gram-negative bacterial RTX secretion protein D signature. Length = 478 Score = 47.5 bits (113), Expect = 6e-08 Identities = 39/238 (16%), Positives = 88/238 (36%), Gaps = 35/238 (14%) Query: 81 ILKRLFAEGSYVREGQALYELDSRTNRATLENAKASLLQQQANLASLRTKLNRYKQLVSS 140 L + + + A+ E +++ A L ++ L + +++ K+ Sbjct: 239 DFSSLLHKQAIAK--HAVLEQENKYVEAV-----NELRVYKSQLEQIESEILSAKEEYQL 291 Query: 141 NAVSKQEYDDLLGQVNVAEAQVSAAKAQVTNANVDLGYSTIRSPISGQSGRSSV-TAGAL 199 + ++L ++ + ++ S IR+P+S + + V T G + Sbjct: 292 VTQLFKN--EILDKLRQTTDNIGLLTLELAKNEERQQASVIRAPVSVKVQQLKVHTEGGV 349 Query: 200 VTANQTDPLVTIQQLDPIYVDINQSSAELLRLRQQLSKGSLNNSNNTKVKLKLE--DGST 257 VT +T +V + + D + V + ++ + + +K+E + Sbjct: 350 VTTAET-LMVIVPEDDTLEVTALVQNKDIGFINVGQN-----------AIIKVEAFPYTR 397 Query: 258 YP-IEGQLA--FSDASVNQDTGTIT--LRAVFSN------PNHLLLPGMYTTAQIVQG 304 Y + G++ DA +Q G + + ++ N N L GM TA+I G Sbjct: 398 YGYLVGKVKNINLDAIEDQRLGLVFNVIISIEENCLSTGNKNIPLSSGMAVTAEIKTG 455 Score = 42.5 bits (100), Expect = 2e-06 Identities = 27/130 (20%), Positives = 58/130 (44%), Gaps = 8/130 (6%) Query: 55 VEQSVELSGR-TSAYQISEVRPQTSGVILKRLFAEGSYVREGQALYELDSRTNRATLENA 113 VE +G+ T + + E++P + ++ + + EG VR+G L +L + A Sbjct: 80 VEIVATANGKLTHSGRSKEIKPIENSIVKEIIVKEGESVRKGDVLLKLTALGAEADTLKT 139 Query: 114 KASLLQQQANLASLRT-----KLNRYKQLVSSNAVSKQ--EYDDLLGQVNVAEAQVSAAK 166 ++SLLQ + + +LN+ +L + Q +++L ++ + Q S + Sbjct: 140 QSSLLQARLEQTRYQILSRSIELNKLPELKLPDEPYFQNVSEEEVLRLTSLIKEQFSTWQ 199 Query: 167 AQVTNANVDL 176 Q ++L Sbjct: 200 NQKYQKELNL 209
>TYPE3IMRPROT#Type III secretion system inner membrane R protein family signature. Length = 261 Score = 27.4 bits (61), Expect = 0.006 Identities = 9/33 (27%), Positives = 12/33 (36%) Query: 30 AVTAGNIIVRQRGTEFHAGANVGMGRDHTLFAT 62 TAG II Q G F + + + A Sbjct: 95 VRTAGEIIGLQMGLSFATFVDPASHLNMPVLAR 127
>HTHTETR#TetR bacterial regulatory protein HTH signature. Length = 215 Score = 53.5 bits (128), Expect = 5e-11 Identities = 16/60 (26%), Positives = 32/60 (53%) Query: 6 KPKQNRAKNTFESIVSAGFISVMKNGLDHTTVLKVCEIAGVGSGSFYEYFKNKEALFIEM 65 + + A+ T + I+ + G+ T++ ++ + AGV G+ Y +FK+K LF E+ Sbjct: 3 RKTKQEAQETRQHILDVALRLFSQQGVSSTSLGEIAKAAGVTRGAIYWHFKDKSDLFSEI 62
>HTHTETR#TetR bacterial regulatory protein HTH signature. Length = 215 Score = 71.6 bits (175), Expect = 1e-17 Identities = 30/167 (17%), Positives = 63/167 (37%), Gaps = 5/167 (2%) Query: 1 MNKTAGRGRPRNFDRDAALDKAMNLFWRNGYEATSINDLTKEMEINPPSLYASFGNKEKL 60 KT + R LD A+ LF + G +TS+ ++ K + ++Y F +K L Sbjct: 2 ARKTKQEAQET---RQHILDVALRLFSQQGVSSTSLGEIAKAAGVTRGAIYWHFKDKSDL 58 Query: 61 FIEAVDYYVKSFGNYRIEALQE-SLTAQEGIKNLLIRTIDQFYSKPDKTGCLVVSAALS- 118 F E + + G +E + ++ +LI ++ ++ + + + Sbjct: 59 FSEIWELSESNIGELELEYQAKFPGDPLSVLREILIHVLESTVTEERRRLLMEIIFHKCE 118 Query: 119 GSSESKNVQEILSNERRKTVALIKARLEQGQKDGDVAESLNSDVLAD 165 E VQ+ N ++ I+ L+ + + L + A Sbjct: 119 FVGEMAVVQQAQRNLCLESYDRIEQTLKHCIEAKMLPADLMTRRAAI 165
>HTHTETR#TetR bacterial regulatory protein HTH signature. Length = 215 Score = 68.1 bits (166), Expect = 2e-16 Identities = 39/194 (20%), Positives = 64/194 (32%), Gaps = 5/194 (2%) Query: 1 MLKKSPGRPSRIRPTILAAARALFLEHGLE-VRLEAIAAKAGTNRQTLYNHFPTKTALLI 59 M +K+ R IL A LF + G+ L IA AG R +Y HF K+ L Sbjct: 1 MARKTKQEAQETRQHILDVALRLFSQQGVSSTSLGEIAKAAGVTRGAIYWHFKDKSDLFS 60 Query: 60 EVFDHLKTEMEVPFVEQHELKNKRLDQLLLEIGQAVQNHFYHIDVIRLQRLLIIALVEMK 119 E+++ ++ + +E +L EI V + RL +I E Sbjct: 61 EIWELSESNIGELELEYQAKFPGDPLSVLREILIHVLESTVTEERRRLLMEIIFHKCEFV 120 Query: 120 EILPKIQQR---TQGNIKRSLTDILATAHNAGIVKID-QPEEATKAFLGAVMGYAYPATL 175 + +QQ + L A ++ D A G + G Sbjct: 121 GEMAVVQQAQRNLCLESYDRIEQTLKHCIEAKMLPADLMTRRAAIIMRGYISGLMENWLF 180 Query: 176 ISGNIPTPQELQQL 189 + +E + Sbjct: 181 APQSFDLKKEARDY 194
>RTXTOXIND#Gram-negative bacterial RTX secretion protein D signature. Length = 478 Score = 42.9 bits (101), Expect = 1e-06 Identities = 27/117 (23%), Positives = 48/117 (41%), Gaps = 7/117 (5%) Query: 55 GRTVASEISQ-VRPQVNGVVVEQLFKEGSQVSKGQPLYKIDSSLYRDSVDEAAGNLALAK 113 G+ S S+ ++P N +V E + KEG V KG L K+ + + +L A+ Sbjct: 88 GKLTHSGRSKEIKPIENSIVKEIIVKEGESVRKGDVLLKLTALGAEADTLKTQSSLLQAR 147 Query: 114 ATVNSTRLQAERYK-ELIKVNGVSQQELDNAQSAYEQAKATVTVNEALLKTARTNLR 169 R Q EL K+ + + Q+ E+ +T +L+K + + Sbjct: 148 LEQT--RYQILSRSIELNKLPELKLPDEPYFQNVSEEEVLRLT---SLIKEQFSTWQ 199 Score = 41.0 bits (96), Expect = 6e-06 Identities = 47/275 (17%), Positives = 82/275 (29%), Gaps = 52/275 (18%) Query: 52 QLAGRTVASEISQVRPQVNGVVVEQLFKEGSQVSKGQPLY------KIDSSLYRDSVDEA 105 +L +E V ++N E S++ L K + EA Sbjct: 206 ELNLDKKRAERLTVLARINRYE-NLSRVEKSRLDDFSSLLHKQAIAKHAVLEQENKYVEA 264 Query: 106 AGNLALAKATVNSTRLQAERYK-ELIKVNGVSQQELDNAQSAYEQAKATVTVNEALLKTA 164 L + K+ + + K E V + + E Q + + L Sbjct: 265 VNELRVYKSQLEQIESEILSAKEEYQLVTQLFKNE---ILDKLRQTTDNIGLLTLELAKN 321 Query: 165 RTNLRYTQVTAPISGRIGRSSI-TRGALVTSAQT--------DPLATIQKLDPMYVDLTQ 215 + + + AP+S ++ + + T G +VT+A+T D L + + Sbjct: 322 EERQQASVIRAPVSVKVQQLKVHTEGGVVTTAETLMVIVPEDDTLEVTALVQNKDIGFIN 381 Query: 216 SSDEYMALRKQLTENGIKPTELSVRLQLE--NGTNYAEQ-GTFK--FSDIAVDEATGSVT 270 + +++E T Y G K D D+ G V Sbjct: 382 -------------------VGQNAIIKVEAFPYTRYGYLVGKVKNINLDAIEDQRLGLVF 422 Query: 271 LRAAFSNSNNA--------LLPGIYVRAELGTGTR 297 N L G+ V AE+ TG R Sbjct: 423 NVIISIEENCLSTGNKNIPLSSGMAVTAEIKTGMR 457
>ACRIFLAVINRP#Acriflavin resistance protein family signature. Length = 1034 Score = 1123 bits (2906), Expect = 0.0 Identities = 548/1031 (53%), Positives = 734/1031 (71%), Gaps = 5/1031 (0%) Query: 2 LSSFFIARPIFAWVLSICIMALGTISILTLPIEQYPDIAPPGVNVTANYPGASAKTVEDS 61 +++FFI RPIFAWVL+I +M G ++IL LP+ QYP IAPP V+V+ANYPGA A+TV+D+ Sbjct: 1 MANFFIRRPIFAWVLAIILMMAGALAILQLPVAQYPTIAPPAVSVSANYPGADAQTVQDT 60 Query: 62 VTQILEQQIKGIDGLLYFSSSSSSAGQARISLSFDQNTNPDTAQVQVQNAVNQALSRLPQ 121 VTQ++EQ + GID L+Y SS+S SAG I+L+F T+PD AQVQVQN + A LPQ Sbjct: 61 VTQVIEQNMNGIDNLMYMSSTSDSAGSVTITLTFQSGTDPDIAQVQVQNKLQLATPLLPQ 120 Query: 122 EVQQQGITVTKSQGDSLLVFALYDESGTRSSVDISDYMVSTLQDPLSRVDGVGEITVFGA 181 EVQQQGI+V KS L+V ++ + DISDY+ S ++D LSR++GVG++ +FGA Sbjct: 121 EVQQQGISVEKSSSSYLMVAGFVSDNPGTTQDDISDYVASNVKDTLSRLNGVGDVQLFGA 180 Query: 182 QYAMRIWLDPHKLNSYGLMPSDVRTAIEAQNTQITAGELGALPTRDGQALNATVTALSRL 241 QYAMRIWLD LN Y L P DV ++ QN QI AG+LG P GQ LNA++ A +R Sbjct: 181 QYAMRIWLDADLLNKYKLTPVDVINQLKVQNDQIAAGQLGGTPALPGQQLNASIIAQTRF 240 Query: 242 QTVSQFENIILRTQTNGAVVLLKDVARVERGAESYQTSTRLNGKPASGMSIQLASGANAL 301 + +F + LR ++G+VV LKDVARVE G E+Y R+NGKPA+G+ I+LA+GANAL Sbjct: 241 KNPEEFGKVTLRVNSDGSVVRLKDVARVELGGENYNVIARINGKPAAGLGIKLATGANAL 300 Query: 302 ETAERVKAEVTRLTASMPAGLKVAYPRDSTPFVEASVNGVIKTLAEAIVLVIIVMFLFLQ 361 +TA+ +KA++ L P G+KV YP D+TPFV+ S++ V+KTL EAI+LV +VM+LFLQ Sbjct: 301 DTAKAIKAKLAELQPFFPQGMKVLYPYDTTPFVQLSIHEVVKTLFEAIMLVFLVMYLFLQ 360 Query: 362 SWRATLIPAIAVPVVLLGTFGVLSVLGYSINTLTLFAMVLAIGLLVDDAIVVVENVERVM 421 + RATLIP IAVPVVLLGTF +L+ GYSINTLT+F MVLAIGLLVDDAIVVVENVERVM Sbjct: 361 NMRATLIPTIAVPVVLLGTFAILAAFGYSINTLTMFGMVLAIGLLVDDAIVVVENVERVM 420 Query: 422 HEQNVDARQATLISMKEISGALVGIAMVLAAVFLPMAFFGGSVGIIYRQFSVTLVSAMVL 481 E + ++AT SM +I GALVGIAMVL+AVF+PMAFFGGS G IYRQFS+T+VSAM L Sbjct: 421 MEDKLPPKEATEKSMSQIQGALVGIAMVLSAVFIPMAFFGGSTGAIYRQFSITIVSAMAL 480 Query: 482 SAIVALTLSPALCATLLKPANEKHKQRK--FFTWFNRKVEQGQSGYRTKLVAVLGKPKIF 539 S +VAL L+PALCATLLKP + +H + K FF WFN + + Y + +LG + Sbjct: 481 SVLVALILTPALCATLLKPVSAEHHENKGGFFGWFNTTFDHSVNHYTNSVGKILGSTGRY 540 Query: 540 MIIFVGITALLGWQYTRMNTGFLPQEDQGSVMVQFSTPVGTTLAETERVGNQIADYFLTK 599 ++I+ I A + + R+ + FLP+EDQG + P G T T++V +Q+ DY+L Sbjct: 541 LLIYALIVAGMVVLFLRLPSSFLPEEDQGVFLTMIQLPAGATQERTQKVLDQVTDYYLKN 600 Query: 600 EKDNLNVIFMVMGRNNAGSGQNVGMAFAGLKHWDDREGSENTAEAVIARANAHFKSLRNA 659 EK N+ +F V G + +G QN GMAF LK W++R G EN+AEAVI RA +R+ Sbjct: 601 EKANVESVFTVNGFSFSGQAQNAGMAFVSLKPWEERNGDENSAEAVIHRAKMELGKIRDG 660 Query: 660 RVQVLSPAAVRGLGQSSGFELWLQDAENKGRDALIAAQNNVL-KAANADSGLAAVRLNSL 718 V + A+ LG ++GF+ L D G DAL A+N +L AA + L +VR N L Sbjct: 661 FVIPFNMPAIVELGTATGFDFELIDQAGLGHDALTQARNQLLGMAAQHPASLVSVRPNGL 720 Query: 719 EDKAQLQVDIDQRKASALGLAQADISNTLSSAWGGSYINDFIDRGRVKRVYLQGEANYRS 778 ED AQ ++++DQ KA ALG++ +DI+ T+S+A GG+Y+NDFIDRGRVK++Y+Q +A +R Sbjct: 721 EDTAQFKLEVDQEKAQALGVSLSDINQTISTALGGTYVNDFIDRGRVKKLYVQADAKFRM 780 Query: 779 LPQDIGQWYVRGATGQMTPFSSFSSVKWQMGPQMLQRFNGLSAVQLQGSAATGESSGGAM 838 LP+D+ + YVR A G+M PFS+F++ W G L+R+NGL ++++QG AA G SSG AM Sbjct: 781 LPEDVDKLYVRSANGEMVPFSAFTTSHWVYGSPRLERYNGLPSMEIQGEAAPGTSSGDAM 840 Query: 839 DKMQQLVDQ-QQGFNLQWSGLSYQEKLAGGQTIWLYLASIIFIFLCLAALYESWSIPVSV 897 M+ L + G W+G+SYQE+L+G Q L S + +FLCLAALYESWSIPVSV Sbjct: 841 ALMENLASKLPAGIGYDWTGMSYQERLSGNQAPALVAISFVVVFLCLAALYESWSIPVSV 900 Query: 898 MLVIPLGLIGAVVAASLAGFVNDIYFQVAMLTTIGLSAKNAILIVEFA-AAKLEAGQALM 956 MLV+PLG++G ++AA+L ND+YF V +LTTIGLSAKNAILIVEFA + G+ ++ Sbjct: 901 MLVVPLGIVGVLLAATLFNQKNDVYFMVGLLTTIGLSAKNAILIVEFAKDLMEKEGKGVV 960 Query: 957 DAIIEGAGQRLRPIIMTSLAFVAGVLPLAVSTGAGAVSRKEIGIAVTGGMISGTLLSIFF 1016 +A + RLRPI+MTSLAF+ GVLPLA+S GAG+ ++ +GI V GGM+S TLL+IFF Sbjct: 961 EATLMAVRMRLRPILMTSLAFILGVLPLAISNGAGSGAQNAVGIGVMGGMVSATLLAIFF 1020 Query: 1017 VPLFFLLVRRL 1027 VP+FF+++RR Sbjct: 1021 VPVFFVVIRRC 1031
>DHBDHDRGNASE#2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase signature. Length = 261 Score = 75.9 bits (186), Expect = 2e-18 Identities = 50/185 (27%), Positives = 91/185 (49%), Gaps = 2/185 (1%) Query: 7 VLITGASSGIGSVYADRFAQRGHNLILVARDTNRLDKISKDLQEKYGVQVEFIQADLSKD 66 ITGA+ GIG A A +G ++ V + +L+K+ L+ + E AD+ Sbjct: 11 AFITGAAQGIGEAVARTLASQGAHIAAVDYNPEKLEKVVSSLKAE-ARHAEAFPADVRDS 69 Query: 67 QDITKI-EDVLKNDADIEILVNNAGIALNGNFLTQDIKDIEKLITLNMTAVVRLSHAISQ 125 I +I + + I+ILVN AG+ G + ++ E ++N T V S ++S+ Sbjct: 70 AAIDEITARIEREMGPIDILVNVAGVLRPGLIHSLSDEEWEATFSVNSTGVFNASRSVSK 129 Query: 126 PLLRKGKGAIINLGSVLGLAPELGSTIYGASKSFIQFFSQGLHLELKDHGVHVQAVLPSA 185 ++ + G+I+ +GS P Y +SK+ F++ L LEL ++ + V P + Sbjct: 130 YMMDRRSGSIVTVGSNPAGVPRTSMAAYASSKAAAVMFTKCLGLELAEYNIRCNIVSPGS 189 Query: 186 TKTEI 190 T+T++ Sbjct: 190 TETDM 194
>HTHTETR#TetR bacterial regulatory protein HTH signature. Length = 215 Score = 56.9 bits (137), Expect = 2e-12 Identities = 20/76 (26%), Positives = 36/76 (47%) Query: 1 MKVSKTQVKENREKIVEKATQLFRNKGYDGVGIAELMSSAGFTHGGFYKHFTSKTDLVSI 60 + +K + +E R+ I++ A +LF +G + E+ +AG T G Y HF K+DL S Sbjct: 2 ARKTKQEAQETRQHILDVALRLFSQQGVSSTSLGEIAKAAGVTRGAIYWHFKDKSDLFSE 61 Query: 61 TVKHGLEQVLKRIEGL 76 + + + Sbjct: 62 IWELSESNIGELELEY 77
>HTHTETR#TetR bacterial regulatory protein HTH signature. Length = 215 Score = 56.6 bits (136), Expect = 4e-12 Identities = 29/173 (16%), Positives = 64/173 (36%), Gaps = 6/173 (3%) Query: 17 REELLDAGLAHLKNSDAESLSFREMARQIGVSGNAVYRHFENKESFLAALAAKGFQLLQE 76 R+ +LD L S S E+A+ GV+ A+Y HF++K + + + E Sbjct: 13 RQHILDVALRLFSQQGVSSTSLGEIAKAAGVTRGAIYWHFKDKSDLFSEIWELSESNIGE 72 Query: 77 EQSQTLQDANSQPEA----LKLFGLAYINFAKNNRNLFALMFNPDLQKNEALELKEAVGN 132 + + P + + + L + R L ++F+ E +++A N Sbjct: 73 LELEYQAKFPGDPLSVLREILIHVLESTVTEERRRLLMEIIFHKCEFVGEMAVVQQAQRN 132 Query: 133 TYTQLHQLTASIL--GVDENDAQVEVLAMLSCSLVHGLSHLLLEGRLAESEEK 183 + + L ++ +++ + ++ G L+E L + Sbjct: 133 LCLESYDRIEQTLKHCIEAKMLPADLMTRRAAIIMRGYISGLMENWLFAPQSF 185
>DHBDHDRGNASE#2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase signature. Length = 261 Score = 75.9 bits (186), Expect = 1e-17 Identities = 65/262 (24%), Positives = 114/262 (43%), Gaps = 23/262 (8%) Query: 220 AKPLAGKTALVTGASRGIGEAIAHVLARDGAHVICLD-VPQQQADLDRVAADIGGSTLAI 278 AK + GK A +TGA++GIGEA+A LA GAH+ +D P++ + A Sbjct: 3 AKGIEGKIAFITGAAQGIGEAVARTLASQGAHIAAVDYNPEKLEKVVSSLKAEARHAEAF 62 Query: 279 DITAADAG---EKIKTAAAKQGGLDIIVHNAGITRDKTLANMKPELWDLVININ----LS 331 D+ E + G +DI+V+ AG+ R + ++ E W+ ++N + Sbjct: 63 PADVRDSAAIDEITARIEREMGPIDILVNVAGVLRPGLIHSLSDEEWEATFSVNSTGVFN 122 Query: 332 AAERVNDYLLENDGLNANGRIVCVSSISGIAGNLGQTNYAASKAGVIGLVKFTA-PILKN 390 A+ V+ Y+++ G IV V S YA+SKA + K + + Sbjct: 123 ASRSVSKYMMDRRS----GSIVTVGSNPAGVPRTSMAAYASSKAAAVMFTKCLGLELAEY 178 Query: 391 GITINAVAPGFIETQMTAAIPFAIREAGRRMNS----------MQQGGLPVDVAETIAWF 440 I N V+PG ET M ++ A + + +++ P D+A+ + + Sbjct: 179 NIRCNIVSPGSTETDMQWSLWADENGAEQVIKGSLETFKTGIPLKKLAKPSDIADAVLFL 238 Query: 441 ASTASTGVNGNVVRVCGQSLLG 462 S + + + + V G + LG Sbjct: 239 VSGQAGHITMHNLCVDGGATLG 260
>HTHTETR#TetR bacterial regulatory protein HTH signature. Length = 215 Score = 51.9 bits (124), Expect = 1e-10 Identities = 25/169 (14%), Positives = 58/169 (34%), Gaps = 12/169 (7%) Query: 5 NRDQRREMILQAAMQVALAEGFTAMTVRRIATEAQTSTGQVHHHFSSASHLKAEAFLKLM 64 + R+ IL A+++ +G ++ ++ IA A + G ++ HF S L +E + Sbjct: 8 EAQETRQHILDVALRLFSQQGVSSTSLGEIAKAAGVTRGAIYWHFKDKSDLFSEIWELSE 67 Query: 65 EQLDEIEQTL----------KTTSQFQRLFILLGAENIDRLQPYLRLWNEAELLIEQDVE 114 + E+E + E RL + + + + Sbjct: 68 SNIGELELEYQAKFPGDPLSVLREILIHVLESTVTEERRRL--LMEIIFHKCEFVGEMAV 125 Query: 115 IRKAYNLAMQNWHQTIVQAIESGKKVGEFKNISNSTDIAWRLIAFVCGL 163 +++A + I Q ++ + + A + ++ GL Sbjct: 126 VQQAQRNLCLESYDRIEQTLKHCIEAKMLPADLMTRRAAIIMRGYISGL 174
>TCRTETB#Tetracycline resistance protein TetB signature. Length = 458 Score = 262 bits (671), Expect = 1e-84 Identities = 92/419 (21%), Positives = 187/419 (44%), Gaps = 13/419 (3%) Query: 7 ILTIIVLIYLPVTIDATVMHVATPSLSAALNLTANQLLWVIDIYSLIMAGLILPMGALGD 66 IL + ++ ++ V++V+ P ++ N WV + L + G L D Sbjct: 15 ILIWLCILSFFSVLNEMVLNVSLPDIANDFNKPPASTNWVNTAFMLTFSIGTAVYGKLSD 74 Query: 67 RIGFKKLLFIGTAIFGVGSLAAAFSPTAYA-LIASRAVLGLGAAMLIPATLSGIRNAFTE 125 ++G K+LL G I GS+ + ++ LI +R + G GAA PA + + + Sbjct: 75 QLGIKRLLLFGIIINCFGSVIGFVGHSFFSLLIMARFIQGAGAAA-FPALVMVVVARYIP 133 Query: 126 EKQRNFALGLWSTVGGGGAAFGPLVGGFVLEHFHWGAVFLINIPIILVVLVMIAMIIPKQ 185 ++ R A GL ++ G GP +GG + + HW +L+ IP+I ++ V M + K+ Sbjct: 134 KENRGKAFGLIGSIVAMGEGVGPAIGGMIAHYIHWS--YLLLIPMITIITVPFLMKLLKK 191 Query: 186 QEKTDQPINLGQALILVVAILSLIYSIKSAMYNFSVLTVVMFVVGISTLIHFIRSQKRST 245 + + ++ +++ V I+ + S +F +++V+ F++ F++ ++ T Sbjct: 192 EVRIKGHFDIKGIILMSVGIVFFMLFTTSYSISFLIVSVLSFLI-------FVKHIRKVT 244 Query: 246 TPMIDLELFKHPVISTSIVMAVVSMIALVGFELLLSQELQFVHGFSPLQA-AMFIIPFMI 304 P +D L K+ ++ + + GF ++ ++ VH S + ++ I P + Sbjct: 245 DPFVDPGLGKNIPFMIGVLCGGIIFGTVAGFVSMVPYMMKDVHQLSTAEIGSVIIFPGTM 304 Query: 305 AISLGGPLAGICLNKWGLRLVSTVGILISGFSLWGLAQLNFSTDHFLAWTCMVFLGFSIE 364 ++ + G + GI +++ G V +G+ S + L +T F+ + LG Sbjct: 305 SVIIFGYIGGILVDRRGPLYVLNIGVTFLSVSFLTASFLLETTSWFMTIIIVFVLGGLSF 364 Query: 365 IALLASTAAIMSSVPPQKASAAGAIEGMAYELGAGLGVAIFGLMLSWFYSRSIILPAEL 423 + ST S + + + ++ L G G+AI G +LS +LP E+ Sbjct: 365 TKTVISTIVSSSLKQQEAGAGMSLLNFTSF-LSEGTGIAIVGGLLSIPLLDQRLLPMEV 422
>TONBPROTEIN#Gram-negative bacterial tonB protein signature. Length = 239 Score = 63.1 bits (153), Expect = 4e-13 Identities = 33/89 (37%), Positives = 48/89 (53%), Gaps = 6/89 (6%) Query: 382 HQVQQQVQDIAPVSA--VQPVEVISQPVMVEPEPEPEPEPEPEPEPEPEPEPE---PEPE 436 HQV + P+S V P + P V+P PEP EPEPEPEP PEP E + Sbjct: 33 HQVIELPAPAQPISVTMVTP-ADLEPPQAVQPPPEPVVEPEPEPEPIPEPPKEAPVVIEK 91 Query: 437 PEPEPEPEPEPEPEPEPQSNQDLMVFDPN 465 P+P+P+P+P+P + + Q +D+ + Sbjct: 92 PKPKPKPKPKPVKKVQEQPKRDVKPVESR 120 Score = 42.3 bits (99), Expect = 3e-06 Identities = 18/87 (20%), Positives = 37/87 (42%), Gaps = 4/87 (4%) Query: 360 PLAPNEI-LVSEPVQQNGQAVMNHQVQQQVQDIAPVSAVQPVEVISQPVMVEPEPEPEPE 418 P P + +V+ + QAV Q + E + +V +P+P+P+ Sbjct: 41 PAQPISVTMVTPADLEPPQAV---QPPPEPVVEPEPEPEPIPEPPKEAPVVIEKPKPKPK 97 Query: 419 PEPEPEPEPEPEPEPEPEPEPEPEPEP 445 P+P+P + + +P+ + +P P Sbjct: 98 PKPKPVKKVQEQPKRDVKPVESRPASP 124
>FIMBRILLIN#Porphyromonas gingivalis: fimbrillin protein signature. Length = 348 Score = 28.1 bits (62), Expect = 0.036 Identities = 17/63 (26%), Positives = 25/63 (39%), Gaps = 6/63 (9%) Query: 173 ALLSNLTLVDTTANKSYAIKVN-TVNGYILAGKARNFNISPDFKFQTDHKYNISLNINGK 231 A + + D Y + VN N Y +P K + +HKY+I L I G Sbjct: 261 AFNAGWIVADNNPTTYYPVLVNFNSNNYTYDNG-----YTPKNKIERNHKYDIKLTITGP 315 Query: 232 QTS 234 T+ Sbjct: 316 GTN 318
>PF00577#Outer membrane usher protein FimD Length = 878 Score = 291 bits (747), Expect = 4e-88 Identities = 145/800 (18%), Positives = 266/800 (33%), Gaps = 78/800 (9%) Query: 55 LKISIN----SSISTDLISVRQDQDRKLYIRSRDLKVLRVKMDEQTPDNQW---VCID-- 105 + I +N ++ + +Q + L + + + N C+ Sbjct: 80 VDIYLNNGYMATRDVTFNTGDSEQGIVPCLTRAQLASMGLNTASVSGMNLLADDACVPLT 139 Query: 106 -ELKGIRFKYLENEQALNLQVPSNMLTDYSVDLNGQQITSPHLLKMKPLNAAILNYSLY- 163 + + +Q LNL +P ++ N + P L +NA +LNY+ Sbjct: 140 SMIHDATAQLDVGQQRLNLTIPQAFMS------NRARGYIPPELWDPGINAGLLNYNFSG 193 Query: 164 NTITNDENVFSGSAEGIFNSAIGNFSSGVL-------YNGSNENSYSHEKWVRLESKWQY 216 N++ N S A S + N + L YN S+ +S S KW + + + Sbjct: 194 NSVQNRIGGNSHYAYLNLQSGL-NIGAWRLRDNTTWSYNSSDSSSGSKNKWQHINTWLER 252 Query: 217 VDPEKIRIYTLGDFISNSSDWGSSVRLAGFQWSSAYTQRGDLVTSALPQFSGSAALPSTL 276 TLGD + + + G Q +S D P G A + + Sbjct: 253 DIIPLRSRLTLGDGYTQGDIF-DGINFRGAQLASDDNMLPDSQRGFAPVIHGIARGTAQV 311 Query: 277 DLYVNQQKIYSGFVPSGPFDIKQLPFISG-NEVTLVTTDATGQQSITKQAYYFSSKILAK 335 + N IY+ VP GPF I + ++ + +A G I Y + + Sbjct: 312 TIKQNGYDIYNSTVPPGPFTINDIYAAGNSGDLQVTIKEADGSTQIFTVPYSSVPLLQRE 371 Query: 336 GINEFSVDVGIPRYNYGLYSNNYDDATFASGAIRYGYSNSLTLSGGAEASTDGLTNLGTG 395 G +S+ G R F + +G T+ GG + + D G Sbjct: 372 GHTRYSITAGEYRSGNAQQEKPR----FFQSTLLHGLPAGWTIYGGTQLA-DRYRAFNFG 426 Query: 396 FAKNLFGFGVINADIAASQYKDENGYSALLGLEGRISKNISFN--------TSYRKVFDN 447 KN+ G ++ D+ + + S G R N S N YR Sbjct: 427 IGKNMGALGALSVDMTQANSTLPDD-SQHDGQSVRFLYNKSLNESGTNIQLVGYRYSTSG 485 Query: 448 YFDLARVSQIRY------LKDNQSDDEPKNYLSYSALADEIFRAGINYNFYAG-YG-VYL 499 YF+ A + R +D +PK Y+ ++ + + G +YL Sbjct: 486 YFNFADTTYSRMNGYNIETQDGVIQVKPKFTDYYNLAYNKRGKLQLTVTQQLGRTSTLYL 545 Query: 500 GYNQIKYSDNSYKLLSTNLSGSLNKNWG-----FYASAYKD-YENQKDYGIYFAL----- 548 + Y S LN + S K+ ++ +D + + Sbjct: 546 SGSHQTYWGTSNV--DEQFQAGLNTAFEDINWTLSYSLTKNAWQKGRDQMLALNVNIPFS 603 Query: 549 ------RYTPSSRVNAITSISNES-GKTTYRQEINGFSDPQIGAFGWG---GYVERDQDA 598 + +A S+S++ G+ T + G + + + GY Sbjct: 604 HWLRSDSKSQWRHASASYSMSHDLNGRMTNLAGVYG-TLLEDNNLSYSVQTGYAGGGDGN 662 Query: 599 NQNNASVYASYRARAAYLTGRYNRIGDNDQVALSATGSLVAAAGRVFAANEIGDGYAVVT 658 + + +YR Y+ D Q+ +G ++A A V + D +V Sbjct: 663 SGSTGYATLNYRGGYGNANIGYSHSDDIKQLYYGVSGGVLAHANGVTLGQPLNDTVVLVK 722 Query: 659 NAGPQSQILNGGVNLGATDGTGRFLIANLRPYQLHHIYLDPSYLPLEWDVKSTNQTAFVG 718 G + + TD G ++ Y+ + + LD + L D+ + Sbjct: 723 APGAKDAKVENQ-TGVRTDWRGYAVLPYATEYRENRVALDTNTLADNVDLDNAVANVVPT 781 Query: 719 YRQGALIDFGAHQVISGLVKLVDANNSPLLPGYTVRINEQQN-GVVGYDGEVFIQNLLKQ 777 +F A I L+ + NN PL G V Q+ G+V +G+V++ + Sbjct: 782 RGAIVRAEFKARVGIKLLM-TLTHNNKPLPFGAMVTSESSQSSGIVADNGQVYLSGMPLA 840 Query: 778 NKLEV--DLLDHGSCQVNFA 795 K++V ++ C N+ Sbjct: 841 GKVQVKWGEEENAHCVANYQ 860
>TCRTETA#Tetracycline resistance protein signature. Length = 399 Score = 44.8 bits (106), Expect = 3e-07 Identities = 55/316 (17%), Positives = 113/316 (35%), Gaps = 14/316 (4%) Query: 19 GILSSIAIVTRFFAPLVWGWVADKSGKRMLLVRLATWMESCIWLAIFIVPNTFQSIALLM 78 GIL ++ + +F V G ++D+ G+R +L L + + + AI + + Sbjct: 46 GILLALYALMQFACAPVLGALSDRFGRRPVL--LVSLAGAAVDYAIMATAPFLWVLYIGR 103 Query: 79 LIFSFFQNAILAQFEGVTLFWLGDQKAKLYGKIRKWGSVGFIVGVFVIGALLEIVPISML 138 ++ + GD++A+ +G + G + G V+G L+ Sbjct: 104 IVAGITGATGAVAGAYIADITDGDERARHFGFMSACFGFGMVAGP-VLGGLMGGFSPHAP 162 Query: 139 PILLLIIASLAFIWS-FTIREP---DGAPTSQKKLEPL----LPVLKRPTVAAFFTIEFI 190 + L F+ F + E + P ++ L PL A + Sbjct: 163 FFAAAALNGLNFLTGCFLLPESHKGERRPLRREALNPLASFRWARGMTVVAALMAVFFIM 222 Query: 191 LLFSHAPFYSFYSNFLKSLNFSTTEIGF-LWAMGVFAEIFMFSIASKIFQRFSWRSLVVV 249 L P + ++ T IG L A G+ + I + R R +++ Sbjct: 223 QLVGQVPAALWVIFGEDRFHWDATTIGISLAAFGILHSLAQAMITGPVAARLGERRALML 282 Query: 250 CLLVTSIRWMLVALFSHYFVGQLFAQCLHAFSFGLFHLIAMRVIFQNFSAGQQGRGQALY 309 ++ ++L+A + ++ L + G+ L AM + + +QG+ Q Sbjct: 283 GMIADGTGYILLAFATRGWMAFPIMVLLASGGIGMPALQAM--LSRQVDEERQGQLQGSL 340 Query: 310 STMWGLGVAFGSVLAG 325 + + L G +L Sbjct: 341 AALTSLTSIVGPLLFT 356
>RTXTOXIND#Gram-negative bacterial RTX secretion protein D signature. Length = 478 Score = 39.0 bits (91), Expect = 2e-06 Identities = 24/92 (26%), Positives = 41/92 (44%), Gaps = 8/92 (8%) Query: 46 LPAA-PVAAAPVAKTPRGAVETSPMVGVFYAAPSPGEAPFVKVGQTVSAGETLGIIEAMK 104 LPA + PV++ PR ++G A + +V +A L K Sbjct: 42 LPAHLELIETPVSRRPRLVAYF--IMGFLVIAF--ILSVLGQVEIVATANGKLTHSGRSK 97 Query: 105 IMNPIEATQSGVVEEILVKNGDVIQFGQPLFR 136 + PIE + +V+EI+VK G+ ++ G L + Sbjct: 98 EIKPIE---NSIVKEIIVKEGESVRKGDVLLK 126
>PF04183#IucA / IucC family Length = 580 Score = 370 bits (951), Expect = e-117 Identities = 143/598 (23%), Positives = 239/598 (39%), Gaps = 48/598 (8%) Query: 600 LAENRVMGQLLEALIFENTFKYEFSKGQIKFYISDTVFYTCAAKRHFSFKRIKLDPSSLI 659 L R++ ++L L +E F E + A+R + + +D +L Sbjct: 8 LVNRRLVAKMLSELEYEQVFHAESQGDDRYCINLPGAQWRFIAER-GIWGWLWIDAQTLR 66 Query: 660 RSNITLDAETRPNLKTLLADLKNIIEADPVKWQNFNDELNLTYVKHAQTLSQA---PAQP 716 ++ + A +TLL LK ++ +L T + Q L A Sbjct: 67 CADEPVLA------QTLLMQLKQVLSMSDATVAEHMQDLYATLLGDLQLLKARRGLSASD 120 Query: 717 LRTLPYLEQEARITNAHLYHPSFKSRIGFDLKENQKYAPELSEGFTVQWAATHNSLCKLV 776 L L + ++ H K R G+ + ++YAPE + F + W A Sbjct: 121 LINLNADRLQCLLS-GHPKFVFNKGRRGWGKEALERYAPEYANTFRLHWLAVKREHMIWR 179 Query: 777 LSETINLEQLYKQHFSEKDLQAINNQLKEQHVDFKDYILTPIHPWQWDKIIELYYQDAIS 836 +++ QL ++ + +E +D +++ P+HPWQW + I + + Sbjct: 180 CDNEMDIHQLLTAAMDPQEFARFSQVWQENGLD-HNWLPLPVHPWQWQQKIATDFIADFA 238 Query: 837 NQLIIPLDIEGPTYLPQQSIRTLSNISDISALSLKLAMNLVNTSTSRVLAPHTVQNAAKM 896 ++ L G +L QQS+RTL+N S L +KL + + NTS R + + Sbjct: 239 EGRMVSLGEFGDQWLAQQSLRTLTNASRRGGLDIKLPLTIYNTSCYRGIPGRYIAAGPLA 298 Query: 897 SDWLYNIVEQDHILEKQRKPVILREIGGLSVNQP--IALPVQYGA----LACIWRESIYS 950 S WL + D L Q VIL E V+ AL L IWRE+ Sbjct: 299 SRWLQQVFATDATL-VQSGAVILGEPAAGYVSHEGYAALARAPYRYQEMLGVIWRENPCR 357 Query: 951 YLKEGESATPVTGLMQLDIDQKPLIDEWIQEYGI--EFWLEKLLTNAYLPIMHILWCHGL 1008 +LK ES + LM+ D + +PL +I G+ E WL +L +P+ H+L +G+ Sbjct: 358 WLKPDESPVLMATLMECDENNQPLAGAYIDRSGLDAETWLTQLFRVVVVPLYHLLCRYGV 417 Query: 1009 ALESHAQNMVLIHKNGLPVKAALKDFHDGIRFSRHLLREPELLPNLQDAPKEHAKINPNS 1068 AL +H QN+ L K G+P + LKDF +R + E + L P+E + Sbjct: 418 ALIAHGQNITLAMKEGVPQRVLLKDFQGDMRLVKEEFPEMDSL------PQEVRDVTSR- 470 Query: 1069 FLETHSPNELRDFTQDALWFVNLAELAIFLNEHYDFDEIKFWTMLRTIINQHKEAHPEFS 1128 + FV + L E +F+ +L +++ + + HP+ S Sbjct: 471 -----LSADYLIHDLQTGHFVTVLRFISPLMVRLGVPERRFYQLLAAVLSDYMKKHPQMS 525 Query: 1129 ERYELFNFTDDTIDIEQLASRRF-----------LPEIRLRVQTTPNPLSLIKEIEYE 1175 ER+ LF+ I L + LP ++ NPL L+ + EYE Sbjct: 526 ERFALFSLFRPQIIRVVLNPVKLTWPDLDGGSRMLPNY---LEDLQNPLWLVTQ-EYE 579 Score = 202 bits (514), Expect = 3e-57 Identities = 91/435 (20%), Positives = 159/435 (36%), Gaps = 45/435 (10%) Query: 128 DIANSIENTKFFLENKPSQSATKALSSFQATEQGMLYGHPFHVTSKANLGFSKEDMKKYS 187 D+ ++ L+ + SA+ ++ Q +L GHP V +K G+ KE +++Y+ Sbjct: 98 DLYATLLGDLQLLKARRGLSASDLINLNADRLQCLLSGHPKFVFNKGRRGWGKEALERYA 157 Query: 188 PELGASFQLHYFAVH-SSLIQKLVSETEPSHHIENEVLETAKEHLQENFT------NYEL 240 PE +F+LH+ AV +I + +E + + + + + N+ Sbjct: 158 PEYANTFRLHWLAVKREHMIWRCDNEMDIHQLLTAAMDPQEFARFSQVWQENGLDHNWLP 217 Query: 241 MPTHPWQANFLLQHSSLKKHLNSQDVIYLGALGQTVWPTSSVRTVWLPQS--NLFLKLSI 298 +P HPWQ + + ++ LG G S+RT+ L +KL + Sbjct: 218 LPVHPWQWQQKI-ATDFIADFAEGRMVSLGEFGDQWLAQQSLRTLTNASRRGGLDIKLPL 276 Query: 299 DVRITSFIRNNPMDEMERAIDASKI---IINHKINEQYPDLVILPELEAKTVKIPELESS 355 + TS R P + AS+ + VIL E A V Sbjct: 277 TIYNTSCYRGIPGRYIAAGPLASRWLQQVFATDATLVQSGAVILGEPAAGYVSHE----- 331 Query: 356 FGIIYRAGLTPEVLENTRMLGGLVEEN-----ENHEIPLLSFIQQAAPNQN---LQSTDA 407 A L MLG + EN + E P+L N + Sbjct: 332 ----GYAALARAPYRYQEMLGVIWRENPCRWLKPDESPVLMATLMECDENNQPLAGAYID 387 Query: 408 KDFITF--WWKQYVKVSLIPLVELFANKGISVEAHMQNSLMEFKNGYPHRLILRDMEGIS 465 + + W Q +V ++PL L G+++ AH QN + K G P R++L+D +G Sbjct: 388 RSGLDAETWLTQLFRVVVVPLYHLLCRYGVALIAHGQNITLAMKEGVPQRVLLKDFQG-- 445 Query: 466 IVPEMIEDDSSISEDSTVWFSQKDAWTFLKYYLLINHI--------AHLISAISRVTAIE 517 +M E ++ +D + L LI+ + IS + + Sbjct: 446 ---DMRLVKEEFPEMDSLPQEVRDVTSRLSADYLIHDLQTGHFVTVLRFISPLMVRLGVP 502 Query: 518 EFELWQATRLTLTQE 532 E +Q L+ Sbjct: 503 ERRFYQLLAAVLSDY 517
>TCRTETA#Tetracycline resistance protein signature. Length = 399 Score = 98.7 bits (246), Expect = 6e-25 Identities = 79/389 (20%), Positives = 164/389 (42%), Gaps = 25/389 (6%) Query: 9 FIILLCQFFSTFGLMVLIPIMPLYMEKLTAHMSAPTIWAGLALAAPAIGSLFTAPIVGHL 68 +IL G+ +++P++P + L + G+ LA A+ AP++G L Sbjct: 8 IVILSTVALDAVGIGLIMPVLPGLLRDLVHSNDVTAHY-GILLALYALMQFACAPVLGAL 66 Query: 69 SDTFGHKKALLLSLAGFCISILLMASAQHLYLFIFARILLGFCGLS-VILNAYVSYLSNE 127 SD FG + LL+SLAG + +MA+A L++ RI+ G G + + AY++ +++ Sbjct: 67 SDRFGRRPVLLVSLAGAAVDYAIMATAPFLWVLYIGRIVAGITGATGAVAGAYIADITDG 126 Query: 128 QERGAAFGQLQSSVALACLCGPVLGGIFMDQWRVEVLLNATAFVVMTLIVIASFVLTNPV 187 ER FG + + + GPVLGG M + A A + + F+L Sbjct: 127 DERARHFGFMSACFGFGMVAGPVLGG-LMGGFSPHAPFFAAAALNGLNFLTGCFLLPESH 185 Query: 188 KTEASKTKEKSKLP------AFFDRTIFSWLSAGILVQAGGFGLVSCFVLYISEISQSTH 241 K E + ++ P A + + ++ ++Q G + +V++ + Sbjct: 186 KGERRPLRREALNPLASFRWARGMTVVAALMAVFFIMQLVGQVPAALWVIFGEDRFHWDA 245 Query: 242 SSLSAA-SLTGTIHALSWGAAF-IAATYWGKRNDDKGDSFNNFIYASLICGITIFALI-W 298 +++ + + G +H+L+ A G+R + +I T + L+ + Sbjct: 246 TTIGISLAAFGILHSLAQAMITGPVAARLGER---------RALMLGMIADGTGYILLAF 296 Query: 299 VSNIWLVLVLRLIQGFCFAALIPSILHTISLKAGAQSQGKVIGISNSAFVLGQLIGPITI 358 + W+ + ++ +P++ +S + + QG++ G + L ++GP+ Sbjct: 297 ATRGWMAFPIMVLLA-SGGIGMPALQAMLSRQVDEERQGQLQGSLAALTSLTSIVGPLLF 355 Query: 359 TLTYSFFNITAALICTSLFFIGAGLVVIL 387 T Y+ + + GA L ++ Sbjct: 356 TAIYA---ASITTWNGWAWIAGAALYLLC 381
>PF04183#IucA / IucC family Length = 580 Score = 106 bits (265), Expect = 3e-26 Identities = 74/469 (15%), Positives = 153/469 (32%), Gaps = 57/469 (12%) Query: 134 ELLSLVADRPFHPFAHSK-----GELASLT--TQKEIEVYWWAFKKDDVI-NNMESVPHK 185 L L++ P F + L ++W A K++ +I + Sbjct: 128 RLQCLLSGHPKFVFNKGRRGWGKEALERYAPEYANTFRLHWLAVKREHMIWRCDNEMDIH 187 Query: 186 ELLLSEVEESLITNKMAEL-----SDDYLALPLLETQ-----HRYLKLDENKYEGIDLNH 235 +LL + ++ ++L LP+ Q D + + L Sbjct: 188 QLLTAAMDPQEFARFSQVWQENGLDHNWLPLPVHPWQWQQKIATDFIADFAEGRMVSLGE 247 Query: 236 VTTIGLPTSSLRTLIHNTNP-TLHLKLSTNAKTLGAIRSMPGRYLMNGHTAYDFLNDVIN 294 L SLRTL + + L +KL R +PGRY+ G A +L V Sbjct: 248 FGDQWLAQQSLRTLTNASRRGGLDIKLPLTIYNTSCYRGIPGRYIAAGPLASRWLQQVFA 307 Query: 295 ETSLLKNRLFL-------SNETHWWVLGKREPIVKNLGVIGCQVRHLPDFCRDKNVTPIT 347 + L + +H + ++G R P + +P+ Sbjct: 308 TDATLVQSGAVILGEPAAGYVSHEGYAALARAPYRYQEMLGVIWRENPCRWLKPDESPVL 367 Query: 348 MSALSCTY------VDPW-ETLGVEGDKWSLLKDLSVHFIQTFLTLWAK-GIMPECHGQN 399 M+ L + + G++ + W L L + L + G+ HGQN Sbjct: 368 MATLMECDENNQPLAGAYIDRSGLDAETW--LTQLFRVVVVPLYHLLCRYGVALIAHGQN 425 Query: 400 TMVCYENNKLKCFVLRD-HDTLRICTTAIEQNGFTPPVYT-IDTSTPNNLIFTQNEDLFN 457 + + + +L+D +R+ + P + + + + DL Sbjct: 426 ITLAMKEGVPQRVLLKDFQGDMRLVKEEFPEMDSLPQEVRDVTSRLSADYL---IHDLQT 482 Query: 458 YFITLGIQINLYPIALAALKYTDRTESDFWEMVQDIIQDFVETQPISEQTKSQIQTY-LF 516 + + + E F++++ ++ D+++ P Q + + LF Sbjct: 483 GHF-----VTVLRFISPLMVRLGVPERRFYQLLAAVLSDYMKKHP---QMSERFALFSLF 534 Query: 517 DNKTWPFKQLLTPL----LAQESDSTGMPSKIGTTPNPYHSLSVSSYET 561 + + +L P+ + S +P+ + NP ++ YE+ Sbjct: 535 --RPQIIRVVLNPVKLTWPDLDGGSRMLPNYLEDLQNPLWLVT-QEYES 580
>HTHFIS#FIS bacterial regulatory protein HTH signature. Length = 484 Score = 52.1 bits (125), Expect = 3e-10 Identities = 27/139 (19%), Positives = 52/139 (37%), Gaps = 8/139 (5%) Query: 1 MPKLKIALIDDDHARADYIKNSLLENDFEVVACLTLDHLNIFRLEDLQADVILLDMDHPH 60 M I + DDD A + +L ++V L + D+++ D+ P Sbjct: 1 MTGATILVADDDAAIRTVLNQALSRAGYDVRITSNAATL-WRWIAAGDGDLVVTDVVMPD 59 Query: 61 RDIIESCVSSY-----DLPTVLFTKNSDKDTIKQAIDAGVTAYIVDGIDPARLHTILE-I 114 + + + DLP ++ + + T +A + G Y+ D L I+ Sbjct: 60 ENAFD-LLPRIKKARPDLPVLVMSAQNTFMTAIKASEKGAYDYLPKPFDLTELIGIIGRA 118 Query: 115 SIEQYKKHKKLEGDLKEAQ 133 E ++ KLE D ++ Sbjct: 119 LAEPKRRPSKLEDDSQDGM 137
>DHBDHDRGNASE#2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase signature. Length = 261 Score = 59.7 bits (144), Expect = 9e-13 Identities = 47/189 (24%), Positives = 89/189 (47%), Gaps = 4/189 (2%) Query: 3 KTILITGASSGLGAGMAHEFAAKGYNLAICARRLDRLETLKTELENQYGIKVIAKSLDVT 62 K ITGA+ G+G +A A++G ++A ++LE + + L+ + A DV Sbjct: 9 KIAFITGAAQGIGEAVARTLASQGAHIAAVDYNPEKLEKVVSSLKAE-ARHAEAFPADVR 67 Query: 63 NYDQVFEVFRAFKQEFGYLDRIIVNAGVGNGRRIGKGNFEINRATAETNFISALAQCEAA 122 + + E+ ++E G +D ++ AGV I + E AT N + Sbjct: 68 DSAAIDEITARIEREMGPIDILVNVAGVLRPGLIHSLSDEEWEATFSVNSTGVFNASRSV 127 Query: 123 VEIFREQNAGHLVVMSSMSAMRGLPK-HLSTYAASKAAVAHLAEGIRAELLDTPIKVSTI 181 + ++ +G +V + S A G+P+ ++ YA+SKAA + + EL + I+ + + Sbjct: 128 SKYMMDRRSGSIVTVGSNPA--GVPRTSMAAYASSKAAAVMFTKCLGLELAEYNIRCNIV 185 Query: 182 FPGYIRTEI 190 PG T++ Sbjct: 186 SPGSTETDM 194
>TCRTETB#Tetracycline resistance protein TetB signature. Length = 458 Score = 51.0 bits (122), Expect = 5e-09 Identities = 76/405 (18%), Positives = 153/405 (37%), Gaps = 43/405 (10%) Query: 25 LCMLAYIFSFIDRQILALMIEPIKADLQLSDTQFSLLHGLAFSLFYAVMGLPLAYIADRF 84 LC+L++ FS ++ +L + + I D + ++ AF L +++ ++D+ Sbjct: 19 LCILSF-FSVLNEMVLNVSLPDIANDFNKPPASTNWVN-TAFMLTFSIGTAVYGKLSDQL 76 Query: 85 SRPKLISIGIIVWSLATATCGLSKNFIQ-LFLSRMAVGVGEAALSPAAYSMFSDMFSKDK 143 +L+ GII+ + + +F L ++R G G AA + + K+ Sbjct: 77 GIKRLLLFGIIINCFGSVIGFVGHSFFSLLIMARFIQGAGAAAFPALVMVVVARYIPKEN 136 Query: 144 LGRAVGIYSIGAFLGGGIAFLVGGYVIN--------LLKGVTLIEVPLLGAL----KAWQ 191 G+A G+ +G G+ +GG + + L+ +T+I VP L L + Sbjct: 137 RGKAFGLIGSIVAMGEGVGPAIGGMIAHYIHWSYLLLIPMITIITVPFLMKLLKKEVRIK 196 Query: 192 IAFFVVGLPGIIIGLLFILTVKDPARKGQQLNQNGQVDQVKFSQCLQFIKKHAKTFACHY 251 F + G+ + +G++F + + V + F ++ I+K F Sbjct: 197 GHFDIKGIILMSVGIVFFMLFTTSYSISFLI-----VSVLSFLIFVKHIRKVTDPFVDPG 251 Query: 252 LGFTFYAM-----------ALYSLTSWTPAFYIRKFQLAPTETGYMLGTILLIANTLGVF 300 LG M + S P QL+ E G ++ ++ + + Sbjct: 252 LGKNIPFMIGVLCGGIIFGTVAGFVSMVPYMMKDVHQLSTAEIGSVIIFPGTMSVIIFGY 311 Query: 301 CAGWLNDWFIKKGRQDAPLFTGVIGIVGLIIP---IAFFTQTDQLWLSVSLLIPAMFFAS 357 G L D PL+ IG+ L + +F +T ++++ ++ + Sbjct: 312 IGGILVDRR-------GPLYVLNIGVTFLSVSFLTASFLLETTSWFMTIIIVFVLGGLSF 364 Query: 358 FPLVISATALQMLAPNQFRARLSALFLLVSNLIGLGIGTTLVAII 402 VIS L + A +S L + + G G +V + Sbjct: 365 TKTVISTIVSSSLKQQEAGAGMSLLNFT--SFLSEGTGIAIVGGL 407
>SECA#SecA protein signature. Length = 901 Score = 28.3 bits (63), Expect = 0.014 Identities = 21/105 (20%), Positives = 40/105 (38%), Gaps = 8/105 (7%) Query: 45 IDNTRRKIILSTNALGEASITDIANLSTLKLTTATKAVYRLVEDGIVEVYSSTTDERISM 104 ID R +I+S A + + N L K + + DE+ Sbjct: 216 IDEARTPLIISGPAEDSSEMYKRVNKIIPHLIRQEKEDSETFQGEG----HFSVDEKSRQ 271 Query: 105 VKLTAKGVELVEQINQISVVTLAGILNAFSE---DELHNLNHQLK 146 V LT +G+ L+E++ + G + +S +H++ L+ Sbjct: 272 VNLTERGLVLIEELLVKEGIMDEGE-SLYSPANIMLMHHVTAALR 315
>PF07675#Cleaved Adhesin Length = 1358 Score = 29.3 bits (65), Expect = 0.029 Identities = 27/104 (25%), Positives = 41/104 (39%), Gaps = 10/104 (9%) Query: 41 EPAQDDAEVVKNILKADCEIIAKTNLHELAFGITGINHAFGTPINPKYSELIPGGSSSGS 100 E A D + + LKA + + + LA G I F P + E+I G+ Sbjct: 94 ETAWADPLLTTSQLKA----LTNKDKYFLAIGNCCITAQFDYV-QPCFGEVITRVKEKGA 148 Query: 101 AAAVAAKQADFTLGTDTGGSIRMPAACCGVFGLKPTFGRVSRKG 144 A + + + G D S+ A VFG++PTF S Sbjct: 149 YAYIGSSPNSY-WGEDYYWSVGANA----VFGVQPTFEGTSMGS 187
>HTHFIS#FIS bacterial regulatory protein HTH signature. Length = 484 Score = 375 bits (964), Expect = e-130 Identities = 128/334 (38%), Positives = 192/334 (57%), Gaps = 11/334 (3%) Query: 26 NDPESKKLLEYIKQIAPSEASVLIHGETGTGKELIARQIHNHSKRRNKPFIAVNCGAFSE 85 +++ + ++ ++ +++I GE+GTGKEL+AR +H++ KRRN PF+A+N A Sbjct: 142 RSAAMQEIYRVLARLMQTDLTLMITGESGTGKELVARALHDYGKRRNGPFVAINMAAIPR 201 Query: 86 TLVESELFGHEKGAFTGALSSNAGWFEAANGGTLLLDEIGDLSKRIQVKLLRLLQEREVV 145 L+ESELFGHEKGAFTGA + + G FE A GGTL LDEIGD+ Q +LLR+LQ+ E Sbjct: 202 DLIESELFGHEKGAFTGAQTRSTGRFEQAEGGTLFLDEIGDMPMDAQTRLLRVLQQGEYT 261 Query: 146 RLGSRKSIPVNVRVLAATNVNLEQAILSDQFREDLYYRLNVVTLNIKPLRERKGDILPLA 205 +G R I +VR++AATN +L+Q+I FREDLYYRLNVV L + PLR+R DI L Sbjct: 262 TVGGRTPIRSDVRIVAATNKDLKQSINQGLFREDLYYRLNVVPLRLPPLRDRAEDIPDLV 321 Query: 206 YHFIDKYHAQLGYDKADFSNAAKEKISNYWWPGNIRELENMIHHALLICQNGIIESHDLT 265 HF+ + + G D F A E + + WPGN+RELEN++ + +I + Sbjct: 322 RHFVQQAE-KEGLDVKRFDQEALELMKAHPWPGNVRELENLVRRLTALYPQDVITREIIE 380 Query: 266 L-IQPPTQLNQNKLQEKKASEPVINPKLKEVFHQLFQQND---------GQVYAQFEEQL 315 ++ + + ++ I+ ++E Q F +V A+ E L Sbjct: 381 NELRSEIPDSPIEKAAARSGSLSISQAVEENMRQYFASFGDALPPSGLYDRVLAEMEYPL 440 Query: 316 LRIAYHYCHQNQVKTAQMLGLSRNVIRSRLIDLG 349 + A NQ+K A +LGL+RN +R ++ +LG Sbjct: 441 ILAALTATRGNQIKAADLLGLNRNTLRKKIRELG 474
>HTHFIS#FIS bacterial regulatory protein HTH signature. Length = 484 Score = 370 bits (952), Expect = e-128 Identities = 119/324 (36%), Positives = 179/324 (55%), Gaps = 13/324 (4%) Query: 35 VEQIAPSEASVLIVGETGTGKELVARKIHALSNRKNKPFVAVNCGALSDTLAETELFGHE 94 + ++ ++ +++I GE+GTGKELVAR +H R+N PFVA+N A+ L E+ELFGHE Sbjct: 153 LARLMQTDLTLMITGESGTGKELVARALHDYGKRRNGPFVAINMAAIPRDLIESELFGHE 212 Query: 95 KGAFTGAISLQIGWFEAAHGGTIFLDEIGDLSPSIQVKLLRILQENEVVRVGSRQTKKID 154 KGAFTGA + G FE A GGT+FLDEIGD+ Q +LLR+LQ+ E VG R + D Sbjct: 213 KGAFTGAQTRSTGRFEQAEGGTLFLDEIGDMPMDAQTRLLRVLQQGEYTTVGGRTPIRSD 272 Query: 155 VRVIAATNIRLEEAVYAGNFREDLYFRLKVASLHVLPLRLRTGDILPLAQHFIYDYSQSL 214 VR++AATN L++++ G FREDLY+RL V L + PLR R DI L +HF+ ++ Sbjct: 273 VRIVAATNKDLKQSINQGLFREDLYYRLNVVPLRLPPLRDRAEDIPDLVRHFV-QQAEKE 331 Query: 215 NKKPPMLSEEAQQLLVDYHWPGNIRELENAIHHALLICKNGVIQSYDFQLSGFKHKL--- 271 +EA +L+ + WPGN+RELEN + + VI + Sbjct: 332 GLDVKRFDQEALELMKAHPWPGNVRELENLVRRLTALYPQDVITREIIENELRSEIPDSP 391 Query: 272 ----LTSEYDFSIYRNSNQTLKQLLFSWFEQG-----IEDLNEQLEAEITGAAYEYCHHN 322 SI + + ++Q S+ + + + ++E + AA N Sbjct: 392 IEKAAARSGSLSISQAVEENMRQYFASFGDALPPSGLYDRVLAEMEYPLILAALTATRGN 451 Query: 323 QLHTAKLLGISRNIIRARLIKHGL 346 Q+ A LLG++RN +R ++ + G+ Sbjct: 452 QIKAADLLGLNRNTLRKKIRELGV 475
>DHBDHDRGNASE#2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase signature. Length = 261 Score = 127 bits (319), Expect = 1e-37 Identities = 75/256 (29%), Positives = 126/256 (49%), Gaps = 16/256 (6%) Query: 4 LQNKVCIITGAASGMGESEAIAFAQQGAKLIIADMNLEQANQVAEKIINAGGEAFAFQVD 63 ++ K+ ITGAA G+GE+ A A QGA + D N E+ +V + A AF D Sbjct: 6 IEGKIAFITGAAQGIGEAVARTLASQGAHIAAVDYNPEKLEKVVSSLKAEARHAEAFPAD 65 Query: 64 VTQFDQLKQLVEFTLEKFGRIDVLLNNAGIFD-KYTNSLDTTEELWDRMFAINVKAVFNL 122 V + ++ + G ID+L+N AG+ +SL ++E W+ F++N VFN Sbjct: 66 VRDSAAIDEITARIEREMGPIDILVNVAGVLRPGLIHSL--SDEEWEATFSVNSTGVFNA 123 Query: 123 SNLVLPKMIEQGSGAIINIASIAGLVAQMGGASYTASKHAVIGYTKHLAAVYAKHGIKIN 182 S V M+++ SG+I+ + S V + A+Y +SK A + +TK L A++ I+ N Sbjct: 124 SRSVSKYMMDRRSGSIVTVGSNPAGVPRTSMAAYASSKAAAVMFTKCLGLELAEYNIRCN 183 Query: 183 AICPGTIRTPMTAKMLETRPTDK-------------IPLDRFGEASEVAELAIFLASDEA 229 + PG+ T M + + IPL + + S++A+ +FL S +A Sbjct: 184 IVSPGSTETDMQWSLWADENGAEQVIKGSLETFKTGIPLKKLAKPSDIADAVLFLVSGQA 243 Query: 230 RFMNGSCITIDGGYTI 245 + + +DGG T+ Sbjct: 244 GHITMHNLCVDGGATL 259
>TCRTETB#Tetracycline resistance protein TetB signature. Length = 458 Score = 59.5 bits (144), Expect = 1e-11 Identities = 41/178 (23%), Positives = 76/178 (42%), Gaps = 2/178 (1%) Query: 27 ILFFCFAIIALDGLDVVVMGLIAPQIIQEWGISAQELAPVLSAALVGLAIGALVSGPLSD 86 IL + + L+ +V+ + P I ++ V +A ++ +IG V G LSD Sbjct: 15 ILIWLCILSFFSVLNEMVLNVSLPDIANDFNKPPASTNWVNTAFMLTFSIGTAVYGKLSD 74 Query: 87 KFGRKPVLILSVLGFGIFTLLTAFSTDITHLLIY-RFLTGLGAGAAAPNAATLVSEYAAD 145 + G K +L+ ++ +++ LLI RF+ G GA A +V+ Y Sbjct: 75 QLGIKRLLLFGIIINCFGSVIGFVGHSFFSLLIMARFIQGAGAAAFPALVMVVVARYIPK 134 Query: 146 HRRSFSVTVAYCGFSLGAAAGGFLAAWLIPEFGWRSMLILGGVLPLILVPFLYWKMPE 203 R + + ++G G + + W S L+L ++ +I VPFL + + Sbjct: 135 ENRGKAFGLIGSIVAMGEGVGPAIGGMIAHYIHW-SYLLLIPMITIITVPFLMKLLKK 191
>HTHTETR#TetR bacterial regulatory protein HTH signature. Length = 215 Score = 72.4 bits (177), Expect = 6e-18 Identities = 39/196 (19%), Positives = 79/196 (40%), Gaps = 16/196 (8%) Query: 8 GPSLEKTQETKKKIIDSALQHFIEVGFARAKISDIAKHAELGKGTIYSYFETKDQLFEAV 67 + ++ QET++ I+D AL+ F + G + + +IAK A + +G IY +F+ K LF + Sbjct: 3 RKTKQEAQETRQHILDVALRLFSQQGVSSTSLGEIAKAAGVTRGAIYWHFKDKSDLFSEI 62 Query: 68 IDALINDSFRPIRASEIT-------QNETVYEFICKKIIPSVLTLERTGRADMALLILRE 120 + S I E+ +V I ++ T+ R + +I + Sbjct: 63 WE----LSESNIGELELEYQAKFPGDPLSVLREILIHVLE--STVTEERRRLLMEIIFHK 116 Query: 121 GNNFPH--IRQTYVNKIFLPIQYELEQLTSLAIQRGELSATISPQQFALLIVSPMWMGMI 178 + Q + L +EQ I+ L A + ++ A+++ + G++ Sbjct: 117 CEFVGEMAVVQQAQRNLCLESYDRIEQTLKHCIEAKMLPADLMTRRAAIIMRGYI-SGLM 175 Query: 179 HNGILNPNEVLSLETL 194 N + P + Sbjct: 176 ENWLFAPQSFDLKKEA 191
>TCRTETA#Tetracycline resistance protein signature. Length = 399 Score = 57.5 bits (139), Expect = 3e-11 Identities = 59/319 (18%), Positives = 109/319 (34%), Gaps = 11/319 (3%) Query: 5 KSSVQYCIISFALCLAALSTALASPLYAIYEQEWGVSTSQI---GYIFISYMLGVVFSLL 61 K + +I + L A+ L P+ ++ S G + Y L Sbjct: 2 KPNRPLIVILSTVALDAVGIGLIMPVLPGLLRDLVHSNDVTAHYGILLALYALMQFACAP 61 Query: 62 FLNKLNAIYHYKNVILVSLALTILGLMLSALASSVWLLGFSRFLIGIASGLITTAAMVGL 121 L L+ + + V+LVSLA + + A A +W+L R + GI A + Sbjct: 62 VLGALSDRFGRRPVLLVSLAGAAVDYAIMATAPFLWVLYIGRIVAGITGATGAVAGAY-I 120 Query: 122 KDQYPFRNKALAEKLTSIITVLGFGLGPLVGGILADHTVRPLADPYWIIIFFSLLIFI-S 180 D +A S G GP++GG++ + P++ + L F+ Sbjct: 121 ADITDGDERARHFGFMSACFGFGMVAGPVLGGLMGGFSPHA---PFFAAAALNGLNFLTG 177 Query: 181 VFWVKPRFKIEKKYQLNELLKLQGLALPQVASRKVFWVCSVAALCS-FGAF--SLYAALA 237 F + K E++ E L V + +V + G +L+ Sbjct: 178 CFLLPESHKGERRPLRREALNPLASFRWARGMTVVAALMAVFFIMQLVGQVPAALWVIFG 237 Query: 238 GTFIKELPIKSSATLTGVSISIILFVSVLSQLFCKSFKELHVLYAGLLALLLGTISLVMA 297 +L I L ++++ E L G++A G I L A Sbjct: 238 EDRFHWDATTIGISLAAFGILHSLAQAMITGPVAARLGERRALMLGMIADGTGYILLAFA 297 Query: 298 EVEHIVWFLLISILLTGMG 316 + + +++ + G+G Sbjct: 298 TRGWMAFPIMVLLASGGIG 316
>TCRTETA#Tetracycline resistance protein signature. Length = 399 Score = 65.6 bits (160), Expect = 9e-14 Identities = 41/184 (22%), Positives = 74/184 (40%), Gaps = 13/184 (7%) Query: 24 IFLCLMIVVVDGIDISIMGFVAPVIKQQWGITTT---DLAPVMSAALIGLAVGAVISGPL 80 + + L V +D + I ++ V P + + + +++ + A + G L Sbjct: 7 LIVILSTVALDAVGIGLIMPVLPGLLRDLVHSNDVTAHYGILLALYALMQFACAPVLGAL 66 Query: 81 ADKFGRKKLLIINLMGFGVFTLCAAVSSNVTELMMFRFIAGLFMGGVMPQAVTLVTDYSP 140 +D+FGR+ +L+++L G V A + + L + R +AG+ G A + D + Sbjct: 67 SDRFGRRPVLLVSLAGAAVDYAIMATAPFLWVLYIGRIVAGI-TGATGAVAGAYIADITD 125 Query: 141 M----RMNGRMVTIILSGFTIGAAIGGFLAAWVIPHFNWHAMMIIGGVLPLVLAVIAVFK 196 R G M G G +GG + F+ HA L + + F Sbjct: 126 GDERARHFGFMSACFGFGMVAGPVLGGLMGG-----FSPHAPFFAAAALNGLNFLTGCFL 180 Query: 197 LPES 200 LPES Sbjct: 181 LPES 184
>TCRTETB#Tetracycline resistance protein TetB signature. Length = 458 Score = 48.7 bits (116), Expect = 2e-08 Identities = 41/183 (22%), Positives = 77/183 (42%), Gaps = 3/183 (1%) Query: 22 KLIMWLCFLIVAIDGFDTAAVGFIAPALKAEWGLQATDLAPLFGAGLFGLMAGALIFGPL 81 ++++WLC L + + P + ++ + A + G ++G L Sbjct: 14 QILIWLCIL-SFFSVLNEMVLNVSLPDIANDFNKPPASTNWVNTAFMLTFSIGTAVYGKL 72 Query: 82 SDKLGRKPILIGSVIMFGIASVFASFSADLQTLIIW-RFLTGLGLGGALPNAITLTSEYA 140 SD+LG K +L+ +I+ SV +L+I RF+ G G + + + Y Sbjct: 73 SDQLGIKRLLLFGIIINCFGSVIGFVGHSFFSLLIMARFIQGAGAAAFPALVMVVVARYI 132 Query: 141 PTSRRSNLVTMMFCGFTVGSALGGIFSAQLLPHIGWHGILLIGGVLPLATVPFLYFLLPE 200 P R ++ +G +G + +I W LL+ ++ + TVPFL LL + Sbjct: 133 PKENRGKAFGLIGSIVAMGEGVGPAIGGMIAHYIHW-SYLLLIPMITIITVPFLMKLLKK 191 Query: 201 SIR 203 +R Sbjct: 192 EVR 194
>RTXTOXIND#Gram-negative bacterial RTX secretion protein D signature. Length = 478 Score = 116 bits (293), Expect = 3e-31 Identities = 63/369 (17%), Positives = 121/369 (32%), Gaps = 82/369 (22%) Query: 67 TIAPKVSGNIEEIYIKDHQTVKKGQLLARIDARDYEAALAEAESNYAKAEAD-------- 118 I P + ++EI +K+ ++V+KG +L ++ A EA + +S+ +A + Sbjct: 98 EIKPIENSIVKEIIVKEGESVRKGDVLLKLTALGAEADTLKTQSSLLQARLEQTRYQILS 157 Query: 119 -------LNEAKLAVERQPTVIRETE---------------------------------- 137 L E KL E + E E Sbjct: 158 RSIELNKLPELKLPDEPYFQNVSEEEVLRLTSLIKEQFSTWQNQKYQKELNLDKKRAERL 217 Query: 138 ---AQLRKVEAGIKLTKDNTARYEQLQALGAESRLITQQSKTTLTEQYADLDSSKEKVTD 194 A++ + E ++ K + L A ++ + + E +L K ++ Sbjct: 218 TVLARINRYENLSRVEKSRLDDFSSLLHKQAIAKHAVLEQENKYVEAVNELRVYKSQLEQ 277 Query: 195 AQYQLNQYK---IQVQAK------------QAALKQAQAALDKAKLNLSYTEVRAPIDGM 239 + ++ K V + L K + + +RAP+ Sbjct: 278 IESEILSAKEEYQLVTQLFKNEILDKLRQTTDNIGLLTLELAKNEERQQASVIRAPVSVK 337 Query: 240 IGQKSAN-VGNFVGAGNPLMVVVPLDQVY-VEANFREIELKQIKIGQPVTVYVDAYNV-- 295 + Q + G V LMV+VP D V A + ++ I +GQ + V+A+ Sbjct: 338 VQQLKVHTEGGVVTTAETLMVIVPEDDTLEVTALVQNKDIGFINVGQNAIIKVEAFPYTR 397 Query: 296 --ELKGVVDSFSPSTGAFFSPISATNATGNFTKIVQRLPLRIKLIENQKDIKLLRPGLSV 353 L G V + + G ++ + L K+I L G++V Sbjct: 398 YGYLVGKVKNINLDA-------IEDQRLGLVFNVIISIEENC-LSTGNKNIP-LSSGMAV 448 Query: 354 VVSVDTNKK 362 + T + Sbjct: 449 TAEIKTGMR 457
>TCRTETB#Tetracycline resistance protein TetB signature. Length = 458 Score = 49.5 bits (118), Expect = 2e-08 Identities = 58/335 (17%), Positives = 109/335 (32%), Gaps = 20/335 (5%) Query: 22 NNRITSITLVDIRGAMGISVDSGYWVNSIYASAMIIGMILSTSWAVIFSMRRVLLFAIGL 81 N + +++L DI S WVN+ + IG + + ++R+LLF I + Sbjct: 29 NEMVLNVSLPDIANDFNKPPASTNWVNTAFMLTFSIGTAVYGKLSDQLGIKRLLLFGIII 88 Query: 82 CLFSSVLIPFSPN-IEIFYLLRGLQGLANGLTIPLLMACALRFLGPDIRLWGLACYALTA 140 F SV+ + + + R +QG L+M R++ + R Sbjct: 89 NCFGSVIGFVGHSFFSLLIMARFIQGAGAAAFPALVMVVVARYIPKENRGKAFGLIGSIV 148 Query: 141 TFFPNLSAALSAFYLDVIGWKMIFFQTIPFCALSAALVYFGIPQDPLNYSRIKTYDWMGA 200 + A+ I W + ++ V F + +D G Sbjct: 149 AMGEGVGPAIGGMIAHYIHWSYLLL----IPMITIITVPFLMKLLKKEVRIKGHFDIKGI 204 Query: 201 ILAIISLASLSTMLLHGNHLDWFHSQLICVLALISAITLPWFFIHEWRYPSPLIKPQMLE 260 IL + + +L ++S ++ F H + P + P + + Sbjct: 205 ILMSVGIV---FFMLFTTSYSISF-------LIVSVLSFLIFVKHIRKVTDPFVDPGLGK 254 Query: 261 IRNFAYAVF-ALFCFVIIGMSTSTLPLNYLSAVHGYKPTQTMWIGLQIAALQFIYI-PIV 318 F V F + S +P + VH + + + + I I Sbjct: 255 NIPFMIGVLCGGIIFGTVAGFVSMVPY-MMKDVHQLSTAEIGSVIIFPGTMSVIIFGYIG 313 Query: 319 VKLLNQAWVDSRYVHGFGLLLVIAGCLGASQLDTT 353 L+++ YV G+ + L AS L T Sbjct: 314 GILVDR--RGPLYVLNIGVTFLSVSFLTASFLLET 346
>HTHTETR#TetR bacterial regulatory protein HTH signature. Length = 215 Score = 75.4 bits (185), Expect = 4e-19 Identities = 36/168 (21%), Positives = 62/168 (36%), Gaps = 4/168 (2%) Query: 2 SVSTKANEKDQKILDAATKFFLIHGFSGTTTDMIQKEAGVSKATMYGCYKNKEAMFAAVI 61 +A E Q ILD A + F G S T+ I K AGV++ +Y +K+K +F+ + Sbjct: 4 KTKQEAQETRQHILDVALRLFSQQGVSSTSLGEIAKAAGVTRGAIYWHFKDKSDLFSEIW 63 Query: 62 ERQCRNMQEQII-LVETKAENLRSALTEIGKTYLCFILSHSGLAFFRVCI---AEAVRFP 117 E N+ E + + S L EI L ++ I E V Sbjct: 64 ELSESNIGELELEYQAKFPGDPLSVLREILIHVLESTVTEERRRLLMEIIFHKCEFVGEM 123 Query: 118 ELSEKFFEVGPQKLANIIAGYLEKSQKNNEIELNSSADIAANIFLALL 165 + ++ + + I L+ + + + AA I + Sbjct: 124 AVVQQAQRNLCLESYDRIEQTLKHCIEAKMLPADLMTRRAAIIMRGYI 171
>NUCEPIMERASE#Nucleotide sugar epimerase signature. Length = 334 Score = 78.7 bits (194), Expect = 1e-18 Identities = 54/222 (24%), Positives = 95/222 (42%), Gaps = 35/222 (15%) Query: 1 MNVLITGGTGFIGKQIAKEILKSGSLTLDDNKPEPIDKIILFDAF----------AGDDL 50 M L+TG GFIG ++K +L++G +++ D A +L Sbjct: 1 MKYLVTGAAGFIGFHVSKRLLEAG------------HQVVGIDNLNDYYDVSLKQARLEL 48 Query: 51 PQDPRVEVIVGDITDKTTVAHI--TENIDVVWHLA--AVVSSAAEADFDLGMDVNLYGLL 106 P + D+ D+ + + + + + V+ V + E + D NL G L Sbjct: 49 LAQPGFQFHKIDLADREGMTDLFASGHFERVFISPHRLAVRYSLE-NPHAYADSNLTGFL 107 Query: 107 NLLEELRKKQTTPRVIFASGCAVFGG--QLPEVVTDETVVTPKSSYGMQKAVGELLVSDY 164 N+LE R + +++AS +V+G ++P TD++V P S Y K EL+ Y Sbjct: 108 NILEGCRHNKIQ-HLLYASSSSVYGLNRKMP-FSTDDSVDHPVSLYAATKKANELMAHTY 165 Query: 165 SRKGFIDGRILRLPTIVVRPGKPNKAASTFFSSIIREPLKGE 206 S + LR T+ G+P+ A F ++ L+G+ Sbjct: 166 SHLYGLPATGLRFFTVYGPWGRPDMALFKFTKAM----LEGK 203
>BCTERIALGSPF#Bacterial general secretion pathway protein F signature. Length = 408 Score = 31.7 bits (72), Expect = 0.002 Identities = 17/83 (20%), Positives = 32/83 (38%), Gaps = 4/83 (4%) Query: 1 MKTSIYKNVGIPILLSVVGSIVWTILSDYIVPAFTSYYIKFSVAYSKKVYASISAHDLIA 60 M++ I + + P +L+VV V +IL +VP +I A + D + Sbjct: 165 MRSRIQQAMIYPCVLTVVAIAVVSILLSVVVPKVVEQFIHMKQALPLSTRVLMGMSDAV- 223 Query: 61 LQQSTYSLLSLLLVIVSILVCAW 83 T+ LL ++ + Sbjct: 224 ---RTFGPWMLLALLAGFMAFRV 243
>HTHTETR#TetR bacterial regulatory protein HTH signature. Length = 215 Score = 50.8 bits (121), Expect = 3e-10 Identities = 10/46 (21%), Positives = 21/46 (45%) Query: 12 SVLHTSRHLFNKYGFHNVGVDRIVESAKIPKATFYNYFHSKERLIE 57 +L + LF++ G + + I ++A + + Y +F K L Sbjct: 15 HILDVALRLFSQQGVSSTSLGEIAKAAGVTRGAIYWHFKDKSDLFS 60
>ACETATEKNASE#Acetate kinase family signature. Length = 400 Score = 31.7 bits (72), Expect = 0.006 Identities = 15/49 (30%), Positives = 22/49 (44%), Gaps = 3/49 (6%) Query: 39 ITPQIEQAIYKDVLYVEPLKQPPHKLSQQIEAAKQVMPKSAQVIEVRPA 87 IT + +AI D + + PL P + I+A Q+MP V A Sbjct: 104 ITDDVLKAI-TDCIELAPLHNPANIEG--IKACTQIMPDVPMVAVFDTA 149
>PF05272#Virulence-associated E family protein Length = 892 Score = 30.0 bits (67), Expect = 0.010 Identities = 14/47 (29%), Positives = 19/47 (40%), Gaps = 7/47 (14%) Query: 31 VILGRNGCGKSTLFKLMAGLEPVKDGLIRYSGKPLSDFKGKDRADLL 77 V+ G G GKSTL + GL+ D GKD + + Sbjct: 600 VLEGTGGIGKSTLINTLVGLDFFSDT-------HFDIGTGKDSYEQI 639
>HTHFIS#FIS bacterial regulatory protein HTH signature. Length = 484 Score = 93.0 bits (231), Expect = 7e-24 Identities = 31/123 (25%), Positives = 61/123 (49%), Gaps = 1/123 (0%) Query: 15 ILVVEDDYDIGDIIENYLKREGMVVIRAMNGKQAIELHSSQPIDLILLDIKLPELNGWEV 74 ILV +DD I ++ L R G V N ++ DL++ D+ +P+ N +++ Sbjct: 6 ILVADDDAAIRTVLNQALSRAGYDVRITSNAATLWRWIAAGDGDLVVTDVVMPDENAFDL 65 Query: 75 LNKIRQ-KAQTPVIMLTALDQDIDKVMALRVGADDFVVKPFNPNEVIARVQAVLRRTQLT 133 L +I++ + PV++++A + + + A GA D++ KPF+ E+I + L + Sbjct: 66 LPRIKKARPDLPVLVMSAQNTFMTAIKASEKGAYDYLPKPFDLTELIGIIGRALAEPKRR 125 Query: 134 NKP 136 Sbjct: 126 PSK 128
>RTXTOXIND#Gram-negative bacterial RTX secretion protein D signature. Length = 478 Score = 51.4 bits (123), Expect = 3e-09 Identities = 28/129 (21%), Positives = 49/129 (37%), Gaps = 15/129 (11%) Query: 59 RTAEIRPQVGGIIERVLFKQGSEVRAGQALYKINSETFEADVNSNRASLNKAEAEVARLK 118 R+ EI+P I++ ++ K+G VR G L K+ + EAD ++SL +A E R + Sbjct: 95 RSKEIKPIENSIVKEIIVKEGESVRKGDVLLKLTALGAEADTLKTQSSLLQARLEQTRYQ 154 Query: 119 VQLDRYEQ----------LLPSNAISKQEVSNAQAQYRQALADVAQMKALLTRQNLNLQY 168 + E +S++EV + ++ + K L Sbjct: 155 ILSRSIELNKLPELKLPDEPYFQNVSEEEVLRLTSLIKEQFSTWQNQKY-----QKELNL 209 Query: 169 ATVRAPISG 177 RA Sbjct: 210 DKKRAERLT 218 Score = 47.9 bits (114), Expect = 4e-08 Identities = 36/207 (17%), Positives = 67/207 (32%), Gaps = 31/207 (14%) Query: 97 EADVNSNRASLNKAEAEVARLKVQLDRYEQLLPSNAISKQEVSNAQAQYRQALADVAQMK 156 ++ ++ L + E+E+ K + QL K E+ + RQ ++ + Sbjct: 265 VNELRVYKSQLEQIESEILSAKEEYQLVTQLF------KNEIL---DKLRQTTDNIGLLT 315 Query: 157 ALLTRQNLNLQYATVRAPISGRIGQ-SFVTEGALVGQGDANTMATIQQIDKVYVDVKQSI 215 L + Q + +RAP+S ++ Q TEG +V + M + + D + V Sbjct: 316 LELAKNEERQQASVIRAPVSVKVQQLKVHTEGGVVTTAE-TLMVIVPEDDTLEVTALVQN 374 Query: 216 SEYERLQAALKTGELSANSEKTVRISNSHGQEYNV---TAKMLFEDINVDPETGDVTF-- 270 + + +++ Y K + D D G V Sbjct: 375 KDIGFINVGQNA---------IIKVEAFPYTRYGYLVGKVKNINLDAIEDQRLGLVFNVI 425 Query: 271 ------RIEVNNTERKLLPGMYVRVNI 291 + N L GM V I Sbjct: 426 ISIEENCLSTGNKNIPLSSGMAVTAEI 452
>ACRIFLAVINRP#Acriflavin resistance protein family signature. Length = 1034 Score = 1057 bits (2734), Expect = 0.0 Identities = 501/1028 (48%), Positives = 704/1028 (68%), Gaps = 9/1028 (0%) Query: 2 MSQFFIRRPVFAWVIAIFIILFGLLSIPKLPIARFPSVAPPQVNISATYPGATAKTINDS 61 M+ FFIRRP+FAWV+AI +++ G L+I +LP+A++P++APP V++SA YPGA A+T+ D+ Sbjct: 1 MANFFIRRPIFAWVLAIILMMAGALAILQLPVAQYPTIAPPAVSVSANYPGADAQTVQDT 60 Query: 62 VVTLIERELSGVKNLLYYSATTDTSGTAEISATFKPGTDVEMAQVDVQNKIKAVEARLPQ 121 V +IE+ ++G+ NL+Y S+T+D++G+ I+ TF+ GTD ++AQV VQNK++ LPQ Sbjct: 61 VTQVIEQNMNGIDNLMYMSSTSDSAGSVTITLTFQSGTDPDIAQVQVQNKLQLATPLLPQ 120 Query: 122 IVRQQGLQVEASSSGFLMLVGINSPNGQYSEVDLSDYLVRNVVEELKRVEGVGKVQSFGA 181 V+QQG+ VE SSS +LM+ G S N ++ D+SDY+ NV + L R+ GVG VQ FGA Sbjct: 121 EVQQQGISVEKSSSSYLMVAGFVSDNPGTTQDDISDYVASNVKDTLSRLNGVGDVQLFGA 180 Query: 182 EKALRIWVDPNKLVSYGLSISDVNNAIRENNVEIAPGRLGDLPANKGQLITIPLSAQGQL 241 + A+RIW+D + L Y L+ DV N ++ N +IA G+LG PA GQ + + AQ + Sbjct: 181 QYAMRIWLDADLLNKYKLTPVDVINQLKVQNDQIAAGQLGGTPALPGQQLNASIIAQTRF 240 Query: 242 SSVEQFRNISLKSKTNGSVIRLSDVANVEIGSQAYNFAILENGKPATAAAIQLSPGANAV 301 + E+F ++L+ ++GSV+RL DVA VE+G + YN NGKPA I+L+ GANA+ Sbjct: 241 KNPEEFGKVTLRVNSDGSVVRLKDVARVELGGENYNVIARINGKPAAGLGIKLATGANAL 300 Query: 302 KTAEGVRAKIEELKLNLPEGMQFSIPYDTAPFVKISIEKVIHTLLEAMVLVFIVMYLFLH 361 TA+ ++AK+ EL+ P+GM+ PYDT PFV++SI +V+ TL EA++LVF+VMYLFL Sbjct: 301 DTAKAIKAKLAELQPFFPQGMKVLYPYDTTPFVQLSIHEVVKTLFEAIMLVFLVMYLFLQ 360 Query: 362 NVRYTLIPAIVAPIALLGTFTVMLLAGFSINVLTMFGMVLAIGIIVDDAIVVVENVERIM 421 N+R TLIP I P+ LLGTF ++ G+SIN LTMFGMVLAIG++VDDAIVVVENVER+M Sbjct: 361 NMRATLIPTIAVPVVLLGTFAILAAFGYSINTLTMFGMVLAIGLLVDDAIVVVENVERVM 420 Query: 422 ATEGLNPKEATSKAMKEITSPIIGITLVLSAVFLPMAFASGSVGIIYKQFTLTMSVSILF 481 + L PKEAT K+M +I ++GI +VLSAVF+PMAF GS G IY+QF++T+ ++ Sbjct: 421 MEDKLPPKEATEKSMSQIQGALVGIAMVLSAVFIPMAFFGGSTGAIYRQFSITIVSAMAL 480 Query: 482 SALLALILTPALCATILKPIDGHHQ--KKGFFAWFDRSFDKVTKKYELMLLKIIKHTVPV 539 S L+ALILTPALCAT+LKP+ H K GFF WF+ +FD Y + KI+ T Sbjct: 481 SVLVALILTPALCATLLKPVSAEHHENKGGFFGWFNTTFDHSVNHYTNSVGKILGSTGRY 540 Query: 540 MMIFVVITGITFAGMKYWPTAFMPEEDQGWFMTSFQLPSDATAERTRNVVNEFENSL--K 597 ++I+ +I P++F+PEEDQG F+T QLP+ AT ERT+ V+++ + Sbjct: 541 LLIYALIVAGMVVLFLRLPSSFLPEEDQGVFLTMIQLPAGATQERTQKVLDQVTDYYLKN 600 Query: 598 DKPDVKSNTTIMGWGFSGAGQNVGVAFTTLKDFKERTS---SATEMTNAVNASMANSSEG 654 +K +V+S T+ G+ FSG QN G+AF +LK ++ER SA + + + +G Sbjct: 601 EKANVESVFTVNGFSFSGQAQNAGMAFVSLKPWEERNGDENSAEAVIHRAKMELGKIRDG 660 Query: 655 ETMAVLPPAIDELGTFSGFSLRLQDRANLGMPALLAAQDQLMQMAAKN-KKFYMVWNEGL 713 + PAI ELGT +GF L D+A LG AL A++QL+ MAA++ V GL Sbjct: 661 FVIPFNMPAIVELGTATGFDFELIDQAGLGHDALTQARNQLLGMAAQHPASLVSVRPNGL 720 Query: 714 PQGDNISLKIDREKLNTLGVKFSDVSDIISTSMGSMYINDFPNQGRMQQVIVQVEAKSRM 773 L++D+EK LGV SD++ IST++G Y+NDF ++GR++++ VQ +AK RM Sbjct: 721 EDTAQFKLEVDQEKAQALGVSLSDINQTISTALGGTYVNDFIDRGRVKKLYVQADAKFRM 780 Query: 774 QLKDILNLKVMGSSGQLVSLSEVVTPQWNKAPQQYNRYNGRPSLSIAGIPNFDTSSGEAM 833 +D+ L V ++G++V S T W + RYNG PS+ I G TSSG+AM Sbjct: 781 LPEDVDKLYVRSANGEMVPFSAFTTSHWVYGSPRLERYNGLPSMEIQGEAAPGTSSGDAM 840 Query: 834 REMEQLIAKLPKGIGFEWTGISLQEKQSESQMAFLLGLSMLVVFLVLAALYESWAIPLSV 893 ME L +KLP GIG++WTG+S QE+ S +Q L+ +S +VVFL LAALYESW+IP+SV Sbjct: 841 ALMENLASKLPAGIGYDWTGMSYQERLSGNQAPALVAISFVVVFLCLAALYESWSIPVSV 900 Query: 894 MLVVPLGIFGAIIAIMSRGLMNDVFFKIGLITIIGLSAKNAILIVEFAK-MLKEEGMSLI 952 MLVVPLGI G ++A NDV+F +GL+T IGLSAKNAILIVEFAK ++++EG ++ Sbjct: 901 MLVVPLGIVGVLLAATLFNQKNDVYFMVGLLTTIGLSAKNAILIVEFAKDLMEKEGKGVV 960 Query: 953 EATVAAAKLRLRPILMTSLAFTCGVIPLVIATGASSETQHALGTGVFGGMISATILAIFF 1012 EAT+ A ++RLRPILMTSLAF GV+PL I+ GA S Q+A+G GV GGM+SAT+LAIFF Sbjct: 961 EATLMAVRMRLRPILMTSLAFILGVLPLAISNGAGSGAQNAVGIGVMGGMVSATLLAIFF 1020 Query: 1013 VPVFFIFI 1020 VPVFF+ I Sbjct: 1021 VPVFFVVI 1028 Score = 88.0 bits (218), Expect = 1e-19 Identities = 53/323 (16%), Positives = 128/323 (39%), Gaps = 13/323 (4%) Query: 723 IDREKLNTLGVKFSDVSDIISTS---MGSMYINDFPNQGRMQQVIVQVEAKSRMQ-LKDI 778 +D + LN + DV + + + + + P QQ+ + A++R + ++ Sbjct: 188 LDADLLNKYKLTPVDVINQLKVQNDQIAAGQLGGTPALPG-QQLNASIIAQTRFKNPEEF 246 Query: 779 LNLKVMGS-SGQLVSLSEVVTPQWNKAPQQYN-RYNGRPSLSIAGIPNFDTSSGEA---- 832 + + + G +V L +V + R NG+P+ + ++ + Sbjct: 247 GKVTLRVNSDGSVVRLKDVARVELGGENYNVIARINGKPAAGLGIKLATGANALDTAKAI 306 Query: 833 MREMEQLIAKLPKGIGFEWT-GISLQEKQSESQMAFLLGLSMLVVFLVLAALYESWAIPL 891 ++ +L P+G+ + + + S ++ L ++++VFLV+ ++ L Sbjct: 307 KAKLAELQPFFPQGMKVLYPYDTTPFVQLSIHEVVKTLFEAIMLVFLVMYLFLQNMRATL 366 Query: 892 SVMLVVPLGIFGAIIAIMSRGLMNDVFFKIGLITIIGLSAKNAILIVE-FAKMLKEEGMS 950 + VP+ + G + + G + G++ IGL +AI++VE +++ E+ + Sbjct: 367 IPTIAVPVVLLGTFAILAAFGYSINTLTMFGMVLAIGLLVDDAIVVVENVERVMMEDKLP 426 Query: 951 LIEATVAAAKLRLRPILMTSLAFTCGVIPLVIATGASSETQHALGTGVFGGMISATILAI 1010 EAT + ++ ++ + IP+ G++ + M + ++A+ Sbjct: 427 PKEATEKSMSQIQGALVGIAMVLSAVFIPMAFFGGSTGAIYRQFSITIVSAMALSVLVAL 486 Query: 1011 FFVPVFFIFILGAVEKLFSSKKK 1033 P +L V K Sbjct: 487 ILTPALCATLLKPVSAEHHENKG 509
>HTHTETR#TetR bacterial regulatory protein HTH signature. Length = 215 Score = 48.9 bits (116), Expect = 1e-09 Identities = 13/63 (20%), Positives = 26/63 (41%) Query: 7 SSKKLQVIRTAIRLFTSHGFHTAGIDLIVKESEITKTTFYNYFASKERLIEMCIAFQKRL 66 + ++ A+RLF+ G + + I K + +T+ Y +F K L + Sbjct: 10 QETRQHILDVALRLFSQQGVSSTSLGEIAKAAGVTRGAIYWHFKDKSDLFSEIWELSESN 69 Query: 67 LKE 69 + E Sbjct: 70 IGE 72
>TCRTETA#Tetracycline resistance protein signature. Length = 399 Score = 65.6 bits (160), Expect = 8e-14 Identities = 70/351 (19%), Positives = 125/351 (35%), Gaps = 43/351 (12%) Query: 58 LGVVFSASLFGLFVGSFLLSSLSDRFGRRPILLISTFMFSILMLVTPHVGNIEQLTAIRF 117 G++ + F + +L +LSDRFGRRP+LL+S ++ + + L R Sbjct: 45 YGILLALYALMQFACAPVLGALSDRFGRRPVLLVSLAGAAVDYAIMATAPFLWVLYIGRI 104 Query: 118 VTGIFLGGIMPNVMAYSSEIVPYQSRIFTMMVISCGYTVGAMLGGGISALLVPWGGWQAI 177 V GI G AY ++I R +S + G + G + L+ + A Sbjct: 105 VAGI-TGATGAVAGAYIADITDGDERARHFGFMSACFGFGMVAGPVLGGLMGGFSP-HAP 162 Query: 178 FYFGGIVPLIIFFITFFKLPESLYFLSENSKNTPKILFWLKKFYPALTFNSEMKIINTTE 237 F+ + + F F LPES K Sbjct: 163 FFAAAALNGLNFLTGCFLLPES------------------------------HKGERRPL 192 Query: 238 VQVKKSPLELFKNKRAFFTYSIWIIS--ILNMISLYFLANWLPTLSKESGLSLNQALMIG 295 + +PL F+ R + + I+ ++ A W + E + A IG Sbjct: 193 RREALNPLASFRWARGMTVVAALMAVFFIMQLVGQVPAALW--VIFGEDRFHWD-ATTIG 249 Query: 296 STLQLGGTIGSI----VMGLKIDKTGFYKVLIPVFLVAVISVALIGYAVSHIVLLFIIIF 351 +L G + S+ + G + G + L+ + L+ +A + I++ Sbjct: 250 ISLAAFGILHSLAQAMITGPVAARLGERRALMLGMIADGTGYILLAFATRGWMAFPIMVL 309 Query: 352 IAGFAIVGGQPAINALSASYYPVSLRTTGVGWSIGIARLGSVIGPLFGGYL 402 +A I G PA+ A+ + + G + L S++GPL + Sbjct: 310 LASGGI--GMPALQAMLSRQVDEERQGQLQGSLAALTSLTSIVGPLLFTAI 358 Score = 35.2 bits (81), Expect = 4e-04 Identities = 36/155 (23%), Positives = 56/155 (36%), Gaps = 5/155 (3%) Query: 277 LPTLSKESGLSLNQALMIGSTLQLGGT---IGSIVMGLKIDKTGFYKVLIPVFLVAVISV 333 LP L ++ S + G L L + V+G D+ G VL+ A + Sbjct: 28 LPGLLRDLVHSNDVTAHYGILLALYALMQFACAPVLGALSDRFGRRPVLLVSLAGAAVDY 87 Query: 334 ALIGYAVSHIVLLFIIIFIAGFAIVGGQPAINALSASYYPVSLRTTGVGWSIGIARLGSV 393 A++ A + +L+I +AG G A A R G+ G V Sbjct: 88 AIMATA-PFLWVLYIGRIVAGITGATG-AVAGAYIADITDGDERARHFGFMSACFGFGMV 145 Query: 394 IGPLFGGYLSQFLVITHLFVIAAIPSLFVIIMLVI 428 GP+ GG + F F AA+ L + + Sbjct: 146 AGPVLGGLMGGFSPHAPFFAAAALNGLNFLTGCFL 180
>HTHTETR#TetR bacterial regulatory protein HTH signature. Length = 215 Score = 62.3 bits (151), Expect = 3e-14 Identities = 36/162 (22%), Positives = 63/162 (38%), Gaps = 8/162 (4%) Query: 6 RRPKHDPKVSENEILNAAEQFLSEHPFRELNVDEVMRRTGLKRPAFYVHFRDKHDLALRL 65 R+ K + + + IL+ A + S+ ++ E+ + G+ R A Y HF+DK DL + Sbjct: 3 RKTKQEAQETRQHILDVALRLFSQQGVSSTSLGEIAKAAGVTRGAIYWHFKDKSDLFSEI 62 Query: 66 VENIGKELFTIADRWL--QGDSPQEDLRRTLVGLVEVYMQHGRVLRAFG------EAAGG 117 E + + + P LR L+ ++E + R E G Sbjct: 63 WELSESNIGELELEYQAKFPGDPLSVLREILIHVLESTVTEERRRLLMEIIFHKCEFVGE 122 Query: 118 DERVDNAYRSLVQDFINAAAQHIKEEQEAGRIKKNLDVEETA 159 V A R+L + + Q +K EA + +L A Sbjct: 123 MAVVQQAQRNLCLESYDRIEQTLKHCIEAKMLPADLMTRRAA 164
>DHBDHDRGNASE#2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase signature. Length = 261 Score = 224 bits (573), Expect = 9e-76 Identities = 104/253 (41%), Positives = 147/253 (58%), Gaps = 3/253 (1%) Query: 5 IVVTGAARGIGAAIAKKLLQQGYQVIGIDRQENPEQWEITQKIESSEISRWQGFQQDITD 64 +TGAA+GIG A+A+ L QG + +D NPE+ E +E + F D+ D Sbjct: 11 AFITGAAQGIGEAVARTLASQGAHIAAVDY--NPEKLEKVVSSLKAEARHAEAFPADVRD 68 Query: 65 QETTAKLITDILNKHS-VTGLVNAAGVLIMRSMLEAKTEDWQTLFAVNVMAPIAISQQLA 123 ++ I + + LVN AGVL + E+W+ F+VN S+ ++ Sbjct: 69 SAAIDEITARIEREMGPIDILVNVAGVLRPGLIHSLSDEEWEATFSVNSTGVFNASRSVS 128 Query: 124 KHFCEKKQGSIVTISSNSSRMPRIQLGMYATSKAALSHYCRNLALEIAPHQVRLNIVSPG 183 K+ +++ GSIVT+ SN + +PR + YA+SKAA + + L LE+A + +R NIVSPG Sbjct: 129 KYMMDRRSGSIVTVGSNPAGVPRTSMAAYASSKAAAVMFTKCLGLELAEYNIRCNIVSPG 188 Query: 184 STLTQMQQQLWTDNSPPPAVIDGDLSQYRTGIPLRKLAQPEDIANTVSFLLSDQAAQITM 243 ST T MQ LW D + VI G L ++TGIPL+KLA+P DIA+ V FL+S QA ITM Sbjct: 189 STETDMQWSLWADENGAEQVIKGSLETFKTGIPLKKLAKPSDIADAVLFLVSGQAGHITM 248 Query: 244 QEIVVDGGATLGV 256 + VDGGATLGV Sbjct: 249 HNLCVDGGATLGV 261
>TCRTETA#Tetracycline resistance protein signature. Length = 399 Score = 34.4 bits (79), Expect = 8e-04 Identities = 51/262 (19%), Positives = 97/262 (37%), Gaps = 14/262 (5%) Query: 13 LKRNAHFRHVFIARTLSLLTIGMLVVAIPKQVYDITGNSLNVA---VAMAFEGIAMFIGL 69 +K N + L + IG+++ +P + D+ ++ A + +A + F Sbjct: 1 MKPNRPLIVILSTVALDAVGIGLIMPVLPGLLRDLVHSNDVTAHYGILLALYALMQFACA 60 Query: 70 LLGGLLSDRKDRKWLILLARGVCGLGFAGLAINAMFEHPSLYAIYFLSAWDGFFGALGVT 129 + G LSDR R+ ++L+ L A + M P L+ +Y G GA G Sbjct: 61 PVLGALSDRFGRRPVLLV-----SLAGAAVDYAIMATAPFLWVLYIGRIVAGITGATGAV 115 Query: 130 AMMAIMPVIVGRENIVQARAISMVS--VRLATVISPAIGGILIAASGVATVYWVSTVGTL 187 A I + G E +AR +S V P +GG++ S A + + + L Sbjct: 116 AGAYIADITDGDE---RARHFGFMSACFGFGMVAGPVLGGLMGGFSPHAPFFAAAALNGL 172 Query: 188 LTVFLLMGLPALKPQHASNGESPLRQLAQGFKFVFKNKVVGSTILIGTLLS-FSSAIRII 246 + LP F++ VV + + + ++ + Sbjct: 173 NFLTGCFLLPESHKGERRPLRREALNPLASFRWARGMTVVAALMAVFFIMQLVGQVPAAL 232 Query: 247 FPQMADEIFHGGAFELGLMYSA 268 + ++ FH A +G+ +A Sbjct: 233 WVIFGEDRFHWDATTIGISLAA 254
>ENTSNTHTASED#Enterobactin synthetase component D signature. Length = 234 Score = 68.9 bits (168), Expect = 3e-16 Identities = 48/172 (27%), Positives = 71/172 (41%), Gaps = 13/172 (7%) Query: 40 HLHIDQRLEHPLKIAQARVERKNEYLCGRVLAQAVLNHHFRLDQPVTSMYEPL--PIWPT 97 H L H ++ A +RK E+L GR+ A L + P+WP Sbjct: 26 REHDLLWLPHHDRLRSAGRKRKAEHLAGRIAAVHALR---EVGVRTVPGMGDKRQPLWPD 82 Query: 98 HVLGSISHSQNKLIVALSNNAIYLGIDIEHWVTSEFAQESAHLVLTPSEFDLWKGKATEF 157 + GSISH + +S I GIDIE ++ A E A ++ E + + F Sbjct: 83 GLFGSISHCATTALAVISRQRI--GIDIEKIMSQHTATELAPSIIDSDERQILQASLLPF 140 Query: 158 FDFSHYVSLIFSVKESLYKAVYPTAKQYIDFLEASVTNIDFENQTLMLTFLP 209 ++L FS KES+YKA + F A VT++ + L LP Sbjct: 141 ---PLALTLAFSAKESVYKA-FSDRVTLPGFNSAKVTSLT--ATHISLHLLP 186
>PF06580#Sensor histidine kinase Length = 349 Score = 27.5 bits (61), Expect = 0.005 Identities = 15/52 (28%), Positives = 22/52 (42%) Query: 25 LLSQHLPTFFKYLGLVLLGIGFIALFASLPKVVAAFCWFMLIIFAWSFLPFM 76 +L+ +F K G + L +G I L VV WF+ W L F+ Sbjct: 54 VLTHAYRSFIKRQGWLKLNMGQIILRVLPACVVIGMVWFVANTSIWRLLAFI 105
>DHBDHDRGNASE#2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase signature. Length = 261 Score = 109 bits (273), Expect = 7e-31 Identities = 76/253 (30%), Positives = 114/253 (45%), Gaps = 16/253 (6%) Query: 5 LKGKVAVVSGGATLIGKAVVQALVSAGAHVAILDIDAKGKAIAESFNHDVMFIQ----TD 60 ++GK+A ++G A IG+AV + L S GAH+A +D + + S D Sbjct: 6 IEGKIAFITGAAQGIGEAVARTLASQGAHIAAVDYNPEKLEKVVSSLKAEARHAEAFPAD 65 Query: 61 LTSDAAIQQAVADIHQHLGEVSYLVNLACTYLDDGFKS-SRQDWLQALDINLVSTVELSR 119 + AAI + A I + +G + LVN+A S S ++W +N SR Sbjct: 66 VRDSAAIDEITARIEREMGPIDILVNVAGVLRPGLIHSLSDEEWEATFSVNSTGVFNASR 125 Query: 120 AFYNDLKNQQ-GSIVNFTSISAKVAQTGRWLYPVSKAAIRQLTQSMAMDFAADGIRVNSV 178 + + +++ GSIV S A V +T Y SKAA T+ + ++ A IR N V Sbjct: 126 SVSKYMMDRRSGSIVTVGSNPAGVPRTSMAAYASSKAAAVMFTKCLGLELAEYNIRCNIV 185 Query: 179 SPGWT-----WSRVIAEVSGNNREKADSVAADYHL---LGRLGHPEEVANVVLFLLSPAA 230 SPG T WS E K + L +L P ++A+ VLFL+S A Sbjct: 186 SPGSTETDMQWSLWADENGAEQVIKGS--LETFKTGIPLKKLAKPSDIADAVLFLVSGQA 243 Query: 231 SFVTGADYAVDGG 243 +T + VDGG Sbjct: 244 GHITMHNLCVDGG 256
>TCRTETB#Tetracycline resistance protein TetB signature. Length = 458 Score = 50.3 bits (120), Expect = 9e-09 Identities = 42/178 (23%), Positives = 81/178 (45%), Gaps = 4/178 (2%) Query: 21 MVFILGFFVFFCDGLDTGIIGFIAPSLLDDWGITKPQLAPVLSAALVGMSIGAIISGPLS 80 ++ L FF L+ ++ P + +D+ V +A ++ SIG + G LS Sbjct: 15 ILIWLCILSFF-SVLNEMVLNVSLPDIANDFNKPPASTNWVNTAFMLTFSIGTAVYGKLS 73 Query: 81 DKFGRKGVIVFTSLLFSIFTILCGFANSTQDLMIY-RFITGVGLGAAMPNISTIVSEYMP 139 D+ G K +++F ++ +++ +S L+I RFI G G A + +V+ Y+P Sbjct: 74 DQLGIKRLLLFGIIINCFGSVIGFVGHSFFSLLIMARFIQGAGAAAFPALVMVVVARYIP 133 Query: 140 VKRKAFLTGLAGCGFMLGISCGGVLSAYLLESYGWAKVIIIGGSIPLILVVALLLKLP 197 + + GL G +G G + + W+ +++I + I+ V L+KL Sbjct: 134 KENRGKAFGLIGSIVAMGEGVGPAIGGMIAHYIHWSYLLLI--PMITIITVPFLMKLL 189
>DHBDHDRGNASE#2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase signature. Length = 261 Score = 127 bits (320), Expect = 1e-37 Identities = 82/264 (31%), Positives = 122/264 (46%), Gaps = 16/264 (6%) Query: 3 KLLDGKIAFITGSASGIGLEIAKKFAQEGAKVVISDMNAEKCQETANSLKEQGFEALSAP 62 K ++GKIAFITG+A GIG +A+ A +GA + D N EK ++ +SLK + A + P Sbjct: 4 KGIEGKIAFITGAAQGIGEAVARTLASQGAHIAAVDYNPEKLEKVVSSLKAEARHAEAFP 63 Query: 63 CDVTDEDAYKQAIELTQKTFGTVDILINNAGFQHVAPIEEFPTAVFQKLVQVMLTGAFIG 122 DV D A + ++ G +DIL+N AG I ++ V TG F Sbjct: 64 ADVRDSAAIDEITARIEREMGPIDILVNVAGVLRPGLIHSLSDEEWEATFSVNSTGVFNA 123 Query: 123 IKHVLPIMKAQKYGRIINMASINGLIGFAGKAGYNSAKHGVIGLTKVAALECARDGITVN 182 + V M ++ G I+ + S + A Y S+K + TK LE A I N Sbjct: 124 SRSVSKYMMDRRSGSIVTVGSNPAGVPRTSMAAYASSKAAAVMFTKCLGLELAEYNIRCN 183 Query: 183 ALCPGYVDTPLVRGQIADLAKTRNVSLDSALEDVILAM-------VPQKRLLSVEEIADY 235 + PG +T + AD ++ E VI +P K+L +IAD Sbjct: 184 IVSPGSTETDMQWSLWAD---------ENGAEQVIKGSLETFKTGIPLKKLAKPSDIADA 234 Query: 236 AIFLASSKAGGVTGQAVVMDGGYT 259 +FL S +AG +T + +DGG T Sbjct: 235 VLFLVSGQAGHITMHNLCVDGGAT 258
>ECOLNEIPORIN#E.coli/Neisseria porin superfamily signature. Length = 331 Score = 64.8 bits (158), Expect = 9e-14 Identities = 76/380 (20%), Positives = 120/380 (31%), Gaps = 61/380 (16%) Query: 1 MKKLLLAAAVATLSINAVQAAPTLYGKLNVSINQVDNKNFDG-----KSDVTEVNSNSSR 55 MKK L+A +A L + A A TLYG + + + +G T + S+ Sbjct: 1 MKKSLIALTLAALPV-AAMADVTLYGTIKAGVETSRSVAHNGAQAASVETGTGIVDLGSK 59 Query: 56 IGVKGEEKLTDKLSAVYLAEWAISTDGSGSDSDLSARNRFIGLKTEGVGTLKVGK----- 110 IG KG+E L + L A++ E S +G+DS R FIGLK G G L+VG+ Sbjct: 60 IGFKGQEDLGNGLKAIWQVEQKASI--AGTDSGWGNRQSFIGLKG-GFGKLRVGRLNSVL 116 Query: 111 YDSYFKTAAGGNQDIFNDDTRLDITNIMYGENRLDNVVGFELDPKLLAGLTFNIMAQTGE 170 D+ D + I E RL + D AGL Sbjct: 117 KDTGDINPWDSKSDYLGVNK------IAEPEARL---ISVRYDSPEFAGL---------- 157 Query: 171 STSDSKQGETGKDSKNDSFDSVSTALGYENKDLGLAVAAAGDFGIKGKYAAYGLKDVYTD 230 S S Q ++ + +S Y+N + A + + K Sbjct: 158 --SGSVQYALNDNAGRHNSESYHAGFNYKNGGFFVQYGGAYKRHHQVQENVNIEK---YQ 212 Query: 231 AYRVTGSYDIAKSGFVVGALWQHAEPTDELTAYGQSYKSDGSIDKAGKAYRGLEEQAYAV 290 +R+ YD AL+ + Q + + V Sbjct: 213 IHRLVSGYD-------NDALY--------ASVAVQQQDAKLVEENYSHN------SQTEV 251 Query: 291 TAAYKIPNTKLKVKAEYASAETQVSGQADRK--IDLYGLGLDYQINKQARFYGIVAQQKR 348 A + + YA + D +G +Y +K+ + Sbjct: 252 AATLAYRFGNVTPRVSYAHGFKGSFDATNYNNDYDQVVVGAEYDFSKRTSALVSAGWLQE 311 Query: 349 DWLNDDDKQTVVGTGIEYNF 368 T G G+ + F Sbjct: 312 GKGESKFVSTAGGVGLRHKF 331
>PF07132#Harpin protein (HrpN) Length = 356 Score = 28.1 bits (62), Expect = 0.024 Identities = 21/53 (39%), Positives = 23/53 (43%) Query: 26 GGLGGILGSVLGQMGGNTSSGAQGGLGGVLGSVLGQVTGNNNNAPQAGGGVQS 78 GGLGG+ S+ G GG G GGLG LGS LG G G Sbjct: 71 GGLGGLGSSLGGLGGGLLGGGLGGGLGSSLGSGLGSALGGGLGGALGAGMNAM 123
>ABC2TRNSPORT#ABC-2 type transport system membrane protein signature. Length = 262 Score = 53.0 bits (127), Expect = 5e-10 Identities = 37/171 (21%), Positives = 72/171 (42%), Gaps = 2/171 (1%) Query: 201 AREREQGTFDQLLVTPYTPLQIMIGKALPPIFVGLMQSTIILLIILFWFKIPMNGSIGLL 260 R Q T++ +L T I++G+ + I ++ + L Sbjct: 92 GRMEGQRTWEAMLYTQLRLGDIVLGEMAWAATKAALAGAGIGVVAAALGYTQWLSLLYAL 151 Query: 261 YFGLLSFNVAVVGVGLSISALSLNMQQAMLFTFLIIMPLMLLSGLLTPVENMPEALQIAT 320 L+ +A +G+ ++AL+ + + + L+I P++ LSG + PV+ +P Q A Sbjct: 152 PVIALT-GLAFASLGMVVTALAPSYDYFIFYQTLVITPILFLSGAVFPVDQLPIVFQTAA 210 Query: 321 YANPLRFGINLVQRVYLEGASFAQVKFNFIPMIILGLVTLPLAAWLFRNRL 371 PL I+L++ + L V + + I ++ L+ L R RL Sbjct: 211 RFLPLSHSIDLIRPIMLGHPV-VDVCQHVGALCIYIVIPFFLSTALLRRRL 260
>ABC2TRNSPORT#ABC-2 type transport system membrane protein signature. Length = 262 Score = 39.5 bits (92), Expect = 1e-05 Identities = 37/149 (24%), Positives = 62/149 (41%), Gaps = 20/149 (13%) Query: 202 ARERERGTLEALFVTPVRPFEIVLAKLI----PYVVIGMIDIVICIVAAY-----FIFEV 252 R + T EA+ T +R +IVL ++ + G V+ Y ++ + Sbjct: 92 GRMEGQRTWEAMLYTQLRLGDIVLGEMAWAATKAALAGAGIGVVAAALGYTQWLSLLYAL 151 Query: 253 PMRGSLFSILSASFLYLVVSLLLGLTISGFAQSQFQASQIALLASFMPALMLSGFVFDTR 312 P+ +L + AS +V +L F Q+ P L LSG VF Sbjct: 152 PVI-ALTGLAFASLGMVVTALAPSYDYFIFYQTLVIT----------PILFLSGAVFPVD 200 Query: 313 NLPLVVQIISQLLPATHFMILIKTLFMGG 341 LP+V Q ++ LP +H + LI+ + +G Sbjct: 201 QLPIVFQTAARFLPLSHSIDLIRPIMLGH 229
>RTXTOXIND#Gram-negative bacterial RTX secretion protein D signature. Length = 478 Score = 52.5 bits (126), Expect = 9e-10 Identities = 48/342 (14%), Positives = 111/342 (32%), Gaps = 21/342 (6%) Query: 3 KKLIVVVLVVIAVVIIGF-WAW--KYNNKNQKDNVLTLYGNVDIRQVSLAFEQSGRIEKL 59 ++ +V ++ ++I F + + + LT G + ++ ++++ Sbjct: 55 RRPRLVAYFIMGFLVIAFILSVLGQVEIVATANGKLTHSGRSKEIKPI----ENSIVKEI 110 Query: 60 LVQEGDKVKAGQVLATLN---TNALHIQAKQAQAQLKAQQE----AIVKQDVGARPEEIT 112 +V+EG+ V+ G VL L A ++ + + Q + +Q ++ PE Sbjct: 111 IVKEGESVRKGDVLLKLTALGAEADTLKTQSSLLQARLEQTRYQILSRSIELNKLPELKL 170 Query: 113 QAKAQLASAQAELDKTNKNLQRLQILVSSTDGRAISQQELDYAKSNKDSAEAAVRERQAN 172 + + E +L + Q + + LD ++ + + A + + Sbjct: 171 PDEPYFQNVSEEEVLRLTSLIKEQFSTWQNQ-KYQKELNLDKKRAERLTVLARINRYENL 229 Query: 173 LELI---IKGARQEDREATKAQYEVTKANLDLINYNLTQAELKSPVNAVVRARLQEVGDM 229 + + + A++ V + + KS + + L + Sbjct: 230 SRVEKSRLDDFSSLLHKQAIAKHAVLEQENKYVEAVNELRVYKSQLEQIESEILSAKEEY 289 Query: 230 TTAQKAVYTLALTDPKWIRVYVN--EQDLSSIKMGGTAQVIRDSDSNQPINGKIGYISSV 287 + L + + +L+ + A VIR S + K+ V Sbjct: 290 QLVTQLFKNEILDKLRQTTDNIGLLTLELAKNEERQQASVIRAPVSVKVQQLKVHTEGGV 349 Query: 288 AEFTPKTVQTEEIRTTLVYEVRVYVNDPSDQLNMGQPVSVKV 329 + TL V D +N+GQ +KV Sbjct: 350 VTTAETLMVIVPEDDTLEVTALVQNKD-IGFINVGQNAIIKV 390
>HTHTETR#TetR bacterial regulatory protein HTH signature. Length = 215 Score = 65.0 bits (158), Expect = 4e-15 Identities = 29/145 (20%), Positives = 55/145 (37%), Gaps = 1/145 (0%) Query: 1 MSRSRRSDGDLTKSKIIEAAGPLIAQYGFAKTANKTIANAANVDLAAINYHFDGREGLYQ 60 M+R + + T+ I++ A L +Q G + T+ IA AA V AI +HF + L+ Sbjct: 1 MARKTKQEAQETRQHILDVALRLFSQQGVSSTSLGEIAKAAGVTRGAIYWHFKDKSDLFS 60 Query: 61 AVLVEAHAHYLDEKYLLELVESTQSPEEKLSLLLETLLHKLTEKDVWHGKVFIRELFSPS 120 + + ++ + E L + P L +L +L ++ + I Sbjct: 61 EIWELSESN-IGELELEYQAKFPGDPLSVLREILIHVLESTVTEERRRLLMEIIFHKCEF 119 Query: 121 EHLLNFIELAGMRKFFLIRRLISQV 145 + ++ A I Q Sbjct: 120 VGEMAVVQQAQRNLCLESYDRIEQT 144
>BCTERIALGSPG#Bacterial general secretion pathway protein G signature. Length = 145 Score = 29.5 bits (66), Expect = 0.008 Identities = 11/26 (42%), Positives = 16/26 (61%) Query: 62 RLTRASGFTLVELLVAIAIFAVLSLL 87 + GFTL+E++V I I VL+ L Sbjct: 3 ATDKQRGFTLLEIMVVIVIIGVLASL 28
>BCTERIALGSPH#Bacterial general secretion pathway protein H signature. Length = 170 Score = 38.0 bits (88), Expect = 2e-06 Identities = 17/55 (30%), Positives = 29/55 (52%), Gaps = 3/55 (5%) Query: 1 MKSKGFTLLEVMVALAIFAVAAVALTKVAMQYTQSTSNAILRTKAQFVAMNEVAL 55 M+ +GFTLLE+M+ L + V+A V + + S ++ +T A+F A Sbjct: 1 MRQRGFTLLEMMLILLLMGVSAGM---VLLAFPASRDDSAAQTLARFEAQLRFVQ 52
>BCTERIALGSPG#Bacterial general secretion pathway protein G signature. Length = 145 Score = 46.4 bits (110), Expect = 5e-09 Identities = 19/40 (47%), Positives = 29/40 (72%), Gaps = 1/40 (2%) Query: 10 QKGFTLIEVMVVIVIMTIMTSLVVLNI-GGVDQKKAMQAR 48 Q+GFTL+E+MVVIVI+ ++ SLVV N+ G ++ +A Sbjct: 7 QRGFTLLEIMVVIVIIGVLASLVVPNLMGNKEKADKQKAV 46
>HTHTETR#TetR bacterial regulatory protein HTH signature. Length = 215 Score = 52.7 bits (126), Expect = 8e-11 Identities = 17/82 (20%), Positives = 37/82 (45%) Query: 3 RQAQFRAREVLIFQVAEQLLLENGEAGMTLDVLAAELDLAKGTLYKHFQSKDELYMLLII 62 + + + I VA +L + G + +L +A + +G +Y HF+ K +L+ + Sbjct: 5 TKQEAQETRQHILDVALRLFSQQGVSSTSLGEIAKAAGVTRGAIYWHFKDKSDLFSEIWE 64 Query: 63 RNERMLLEMVQDTEKAFPEHLA 84 +E + E+ + + FP Sbjct: 65 LSESNIGELELEYQAKFPGDPL 86
>HTHFIS#FIS bacterial regulatory protein HTH signature. Length = 484 Score = 28.6 bits (64), Expect = 0.023 Identities = 17/72 (23%), Positives = 28/72 (38%), Gaps = 2/72 (2%) Query: 20 LLLIHDRPMILRVVDQAKKVEGFDDLCVATDDERIAEICRADGVDVVLTSPDHPSGTDRL 79 +L+ D I V++QA G+D + I A D+V+T P + Sbjct: 6 ILVADDDAAIRTVLNQALSRAGYDVRITSNAATLWRWI-AAGDGDLVVTDVVMP-DENAF 63 Query: 80 SEVARIKGWDAN 91 + RIK + Sbjct: 64 DLLPRIKKARPD 75
>SACTRNSFRASE#Streptothricin acetyltransferase signature. Length = 173 Score = 32.6 bits (74), Expect = 9e-05 Identities = 12/43 (27%), Positives = 22/43 (51%), Gaps = 2/43 (4%) Query: 25 EMTYTWAGESMLIIDATDVNENYRGQGVGRQLLDALVAFVREK 67 ++ W G +I+ V ++YR +GVG LL + + +E Sbjct: 81 KIRSNWNG--YALIEDIAVAKDYRKKGVGTALLHKAIEWAKEN 121
>TCRTETA#Tetracycline resistance protein signature. Length = 399 Score = 38.3 bits (89), Expect = 4e-05 Identities = 43/318 (13%), Positives = 99/318 (31%), Gaps = 12/318 (3%) Query: 58 GQAIAISGIFAVVASLTISRVFKTWDRRHIILLLTLLMIVSGIVITSAHSAALFMLGRAI 117 G +A+ + + + + + RR ++L+ V ++ +A + +GR + Sbjct: 46 GILLALYALMQFACAPVLGALSDRFGRRPVLLVSLAGAAVDYAIMATAPFLWVLYIGRIV 105 Query: 118 LGVVIGGFWAMSTSIVMRLVPPLSVPKALGLLNGGNALATTIAAPLGSFLGSIIGWRGAF 177 G+ G A++ + + + + G ++ LG +G F Sbjct: 106 AGIT-GATGAVAGAYIADITDGDERARHFGFMSACFGFGMVAGPVLGGLMGG-FSPHAPF 163 Query: 178 FCIVPIAIVALIWQFKSMPS--------LPAILSVEKSKNPFGLLKRPIVLYGMTGILLL 229 F + + + +P L + + + ++ Sbjct: 164 FAAAALNGLNFLTGCFLLPESHKGERRPLRREALNPLASFRWARGMTVVAALMAVFFIMQ 223 Query: 230 FMGQFALFTYLRPFLETVTHVDATMLSILLLILGLAGLVGTFVISLILHQHV-YRYLILI 288 +GQ ++ F E H DAT + I L G+ + +I+ + + R +++ Sbjct: 224 LVGQVPAALWVI-FGEDRFHWDATTIGISLAAFGILHSLAQAMITGPVAARLGERRALML 282 Query: 289 PFIMALIAGAFVFGGEHLWFVAILMGFWGFIGTSAPVAWNTWLAQTLHQDAEIGGGLMVA 348 I + W +M G P Q + G + A Sbjct: 283 GMIADGTGYILLAFATRGWMAFPIMVLLASGGIGMPALQAMLSRQVDEERQGQLQGSLAA 342 Query: 349 IIQFAITLGATIGGLLYD 366 + +G + +Y Sbjct: 343 LTSLTSIVGPLLFTAIYA 360
>HTHFIS#FIS bacterial regulatory protein HTH signature. Length = 484 Score = 83.3 bits (206), Expect = 5e-20 Identities = 29/137 (21%), Positives = 63/137 (45%), Gaps = 2/137 (1%) Query: 19 ILIVDDVPENLGLLHESLDQAGYRVLVTTDGLSAIEIAHRCLPDMILLDGNMPHMDGFES 78 IL+ DD +L+++L +AGY V +T++ + D+++ D MP + F+ Sbjct: 6 ILVADDDAAIRTVLNQALSRAGYDVRITSNAATLWRWIAAGDGDLVVTDVVMPDENAFDL 65 Query: 79 CIQLKASPITQFIPVIFMTGLSETEHIVRGFQVGGVDYVTKPLNIEEVLARVKTHLAHAK 138 ++K +PV+ M+ + ++ + G DY+ KP ++ E++ + LA K Sbjct: 66 LPRIKK--ARPDLPVLVMSAQNTFMTAIKASEKGAYDYLPKPFDLTELIGIIGRALAEPK 123 Query: 139 LLQQQKQVIDATETAIL 155 + + ++ Sbjct: 124 RRPSKLEDDSQDGMPLV 140
>HTHFIS#FIS bacterial regulatory protein HTH signature. Length = 484 Score = 56.4 bits (136), Expect = 4e-10 Identities = 23/113 (20%), Positives = 49/113 (43%), Gaps = 11/113 (9%) Query: 929 RKRILVVDNEAVDRGLVANFLKPLGFMIEEAESGIDCLRRVPIFQPNLILMDLNMPLMGG 988 ILV D++A R ++ L G+ + + R + +L++ D+ MP Sbjct: 3 GATILVADDDAAIRTVLNQALSRAGYDVRITSNAATLWRWIAAGDGDLVVTDVVMPDENA 62 Query: 989 WETARLLRQNNITNVPILIISANAGEREVNPQDAVLS-----EDFILKPIDLN 1036 ++ +++ ++P+L++SA A+ + D++ KP DL Sbjct: 63 FDLLPRIKKAR-PDLPVLVMSAQN-----TFMTAIKASEKGAYDYLPKPFDLT 109
>TCRTETB#Tetracycline resistance protein TetB signature. Length = 458 Score = 54.1 bits (130), Expect = 6e-10 Identities = 38/180 (21%), Positives = 77/180 (42%), Gaps = 1/180 (0%) Query: 21 HWSILLWCLLIIVFDGYDLVIYGVVLPLLMQEWSLTAVQAGMLASTALCGMMFGAMFFGT 80 H IL+W ++ F + ++ V LP + +++ + + + G +G Sbjct: 12 HNQILIWLCILSFFSVLNEMVLNVSLPDIANDFNKPPASTNWVNTAFMLTFSIGTAVYGK 71 Query: 81 LADKIGRKNVILICVTLFSGFTFLGAFASSPLEFGVL-RFLAGLGIGGVMPNLVALTSEY 139 L+D++G K ++L + + + +G S ++ RF+ G G ++ + + Y Sbjct: 72 LSDQLGIKRLLLFGIIINCFGSVIGFVGHSFFSLLIMARFIQGAGAAAFPALVMVVVARY 131 Query: 140 APKRIRSTLVGTMFSGYAIGGILSALIGSYLVESQGWQIMFLIAGIPLFLLPVIWKFLPE 199 PK R G + S A+G + IG + W + LI I + +P + K L + Sbjct: 132 IPKENRGKAFGLIGSIVAMGEGVGPAIGGMIAHYIHWSYLLLIPMITIITVPFLMKLLKK 191
>PF03944#delta endotoxin Length = 633 Score = 36.6 bits (84), Expect = 3e-04 Identities = 20/63 (31%), Positives = 29/63 (46%), Gaps = 3/63 (4%) Query: 196 LAKQHQFDETINIQFTSGTTGNPKGTMLTHHNILNNGYFVGEG---IRLTPQDKVCISVP 252 L + ++E NI SGT G + M++ HN NN + V E I L P D ++ Sbjct: 438 LRRPLHYNEIRNIASPSGTPGGARAYMVSVHNRKNNIHAVHENGSMIHLAPNDYTGFTIS 497 Query: 253 LFH 255 H Sbjct: 498 PIH 500
>ANTHRAXTOXNA#Anthrax toxin LF subunit signature. Length = 800 Score = 29.3 bits (65), Expect = 0.026 Identities = 16/41 (39%), Positives = 25/41 (60%), Gaps = 1/41 (2%) Query: 247 VTNDFDLVALE-KLNELQAKFPWFEYRTVVASPESNHERKG 286 +T D+DL AL L E++ + P E+ VV +P S ++KG Sbjct: 488 LTADYDLFALAPSLTEIKKQIPQKEWDKVVNTPNSLEKQKG 528
>DHBDHDRGNASE#2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase signature. Length = 261 Score = 95.1 bits (236), Expect = 1e-25 Identities = 65/268 (24%), Positives = 107/268 (39%), Gaps = 25/268 (9%) Query: 3 NRQRFTDKVVIVTGSAQGIGRGVALQVAAEGGQVIMADRSEYVEEVLKEIQSANG-NAVT 61 N + K+ +TG+AQGIG VA +A++G + D + E + A +A Sbjct: 2 NAKGIEGKIAFITGAAQGIGEAVARTLASQGAHIAAVDYNPEKLEKVVSSLKAEARHAEA 61 Query: 62 INADLETYAGAQAVVAKAIEHYGRVDILINNVGGAIWMKPFEEFSEEEIIKEVNRSLFPT 121 AD+ A + A+ G +DIL+ NV G + S+EE + + Sbjct: 62 FPADVRDSAAIDEITARIEREMGPIDILV-NVAGVLRPGLIHSLSDEEWEATFSVNSTGV 120 Query: 122 LWCCRAVLPAMIKQQSGVIVNVSSIA--TRGINRIPYSASKGGVNALTASLAFEHAKDGI 179 R+V M+ ++SG IV V S + Y++SK T L E A+ I Sbjct: 121 FNASRSVSKYMMDRRSGSIVTVGSNPAGVPRTSMAAYASSKAAAVMFTKCLGLELAEYNI 180 Query: 180 RVNAVATGGTEAPPRKVPRNANPLSQNEKDWMQQVVNQTIDRTF---------MGRYGTI 230 R N V+ G TE W + + + + + + Sbjct: 181 RCNIVSPGSTET------------DMQWSLWADENGAEQVIKGSLETFKTGIPLKKLAKP 228 Query: 231 QEQVNAILFLASDEASYMTGSVISVGGG 258 + +A+LFL S +A ++T + V GG Sbjct: 229 SDIADAVLFLVSGQAGHITMHNLCVDGG 256
>TCRTETB#Tetracycline resistance protein TetB signature. Length = 458 Score = 72.6 bits (178), Expect = 6e-16 Identities = 72/405 (17%), Positives = 148/405 (36%), Gaps = 17/405 (4%) Query: 21 HWKVLIWCLLIIIFDGYDLVIYGVALPLLMQQWSLTAVEAGLLASAALFGMMFGAMIFGT 80 H ++LIW ++ F + ++ V+LP + ++ + +A + G ++G Sbjct: 12 HNQILIWLCILSFFSVLNEMVLNVSLPDIANDFNKPPASTNWVNTAFMLTFSIGTAVYGK 71 Query: 81 LSDKLGRKKTILICVTLFSGFTFIGAFANGPTEFAIL-RFIAGLGIGGVMPNVVALMTEY 139 LSD+LG K+ +L + + + IG + I+ RFI G G V+ ++ Y Sbjct: 72 LSDQLGIKRLLLFGIIINCFGSVIGFVGHSFFSLLIMARFIQGAGAAAFPALVMVVVARY 131 Query: 140 APKKIRSTLVAIMFSGYAIGGMTSALLGAWLVKDMGWQIMFLIAGIPLLLLPLIWKFLPE 199 PK+ R ++ S A+G +G + + W + LI I ++ +P + K L + Sbjct: 132 IPKENRGKAFGLIGSIVAMGEGVGPAIGGMIAHYIHWSYLLLIPMITIITVPFLMKLLKK 191 Query: 200 SLTFLVKSNHSEQAKSIVCKIAPETQVNVNTQLVLNEST-------TTDAPVRALFQQGR 252 + + V + + L S V F Sbjct: 192 EVRIKGHFDIKGIILMSVGIVFFMLFTTSYSISFLIVSVLSFLIFVKHIRKVTDPFVDPG 251 Query: 253 TFSTFMFWIAFFMCLLMVYALGSW--LPKLMLQAGYSLG---ASMLFLFALNIGGMVGAI 307 F I ++ + + + M++ + L + +F + ++ Sbjct: 252 LGKNIPFMIGVLCGGIIFGTVAGFVSMVPYMMKDVHQLSTAEIGSVIIFPGTMSVIIFGY 311 Query: 308 GGGALADRFHLKPVITIMFIVGSAALILLGI---NSPQFILYSLIAIAGAATIGSQILLY 364 GG L DR V+ I S + + + F+ ++ + G + ++ ++ Sbjct: 312 IGGILVDRRGPLYVLNIGVTFLSVSFLTASFLLETTSWFMTIIIVFVLGGLSF-TKTVIS 370 Query: 365 TFVAQFYPTALRSTGMGWASGIGRIGAIIGPVLTGALLTLELPHQ 409 T V+ GM + + G + G LL++ L Q Sbjct: 371 TIVSSSLKQQEAGAGMSLLNFTSFLSEGTGIAIVGGLLSIPLLDQ 415 Score = 32.2 bits (73), Expect = 0.004 Identities = 27/121 (22%), Positives = 49/121 (40%), Gaps = 6/121 (4%) Query: 304 VGAIGGGALADRFHLKPVITIMFIVGSAALILLGINSPQF---ILYSLIAIAGAATIGSQ 360 +G G L+D+ +K ++ I+ ++ + F I+ I AGAA + Sbjct: 64 IGTAVYGKLSDQLGIKRLLLFGIIINCFGSVIGFVGHSFFSLLIMARFIQGAGAAAFPA- 122 Query: 361 ILLYTFVAQFYPTALRSTGMGWASGIGRIGAIIGPVLTGALL-TLELPHQMNFLAIAIPG 419 L+ VA++ P R G I +G +GP + G + + + + I I Sbjct: 123 -LVMVVVARYIPKENRGKAFGLIGSIVAMGEGVGPAIGGMIAHYIHWSYLLLIPMITIIT 181 Query: 420 V 420 V Sbjct: 182 V 182
>HTHTETR#TetR bacterial regulatory protein HTH signature. Length = 215 Score = 44.2 bits (104), Expect = 7e-08 Identities = 18/75 (24%), Positives = 32/75 (42%), Gaps = 1/75 (1%) Query: 1 MSKRQKIAAHNRDELLNAAEECFRIHGI-NVPLQVVIDHAGVGRATFYRNFCDRKALISA 59 K ++ A R +L+ A F G+ + L + AGV R Y +F D+ L S Sbjct: 2 ARKTKQEAQETRQHILDVALRLFSQQGVSSTSLGEIAKAAGVTRGAIYWHFKDKSDLFSE 61 Query: 60 LLERAITQLEQKAAH 74 + E + + + + Sbjct: 62 IWELSESNIGELELE 76
>TCRTETB#Tetracycline resistance protein TetB signature. Length = 458 Score = 38.7 bits (90), Expect = 5e-05 Identities = 28/160 (17%), Positives = 58/160 (36%), Gaps = 9/160 (5%) Query: 41 FIGLFIALSASLSNGFITANLPLIQGEYGLTPSEAAWLPAAYVMANVSSNLILFKARQQY 100 + F L+ + N +LP I ++ P+ W+ A+++ + K Q Sbjct: 21 ILSFFSVLNEMVLN----VSLPDIANDFNKPPASTNWVNTAFMLTFSIGTAVYGKLSDQL 76 Query: 101 GLRVFSEIGLVIFIAVLVLHIFVHTY-EMALFARVVAGLAGA--PLSSLGMYYTMQAFKK 157 G++ G++I V+ H++ + + AR + G A P + + + Sbjct: 77 GIKRLLLFGIIINCFGSVIGFVGHSFFSLLIMARFIQGAGAAAFPALVMVVVARYIPKEN 136 Query: 158 ADMAKGIYIAFGFQQLGVPLAWIISPFLVSTDSWSVLYTF 197 A G+ + +G + I + WS L Sbjct: 137 RGKAFGLIGSIV--AMGEGVGPAIGGMIAHYIHWSYLLLI 174
>RTXTOXIND#Gram-negative bacterial RTX secretion protein D signature. Length = 478 Score = 123 bits (310), Expect = 2e-33 Identities = 67/413 (16%), Positives = 143/413 (34%), Gaps = 83/413 (20%) Query: 34 PTKRSTLLWMLGVLIVGILVILWAWRIGPFATSVQQTDNSYVKGKTTILSSQINGYVKDV 93 P R L ++ ++ + + +G G++ + N VK++ Sbjct: 52 PVSRRPRLVAYFIMGFLVIAFILSV-LGQVEIVATANGKLTHSGRSKEIKPIENSIVKEI 110 Query: 94 VVKDFDHVKKGQVLMHIDATTYD------------------------------------- 116 +VK+ + V+KG VL+ + A + Sbjct: 111 IVKEGESVRKGDVLLKLTALGAEADTLKTQSSLLQARLEQTRYQILSRSIELNKLPELKL 170 Query: 117 -----------QKVTQAASGVEQAKNTLANQT----QSIAQKQADIVAAQAKVDQAKAQY 161 ++V + S +++ +T NQ ++ +K+A+ + A++++ + Sbjct: 171 PDEPYFQNVSEEEVLRLTSLIKEQFSTWQNQKYQKELNLDKKRAERLTVLARINRYENLS 230 Query: 162 ELSLAQLRRYQQLGNSGAASKS---EQDKAAADAENNLAALKQ--AEANVLVANEALKTA 216 + ++L + L + A +K EQ+ +A N L K + + + + Sbjct: 231 RVEKSRLDDFSSLLHKQAIAKHAVLEQENKYVEAVNELRVYKSQLEQIESEILSAKEEYQ 290 Query: 217 QVAE----------AGLEAQVSSAKAQLDQAQTTKDYSVIVAPMDGQLGEVNPR-VGQYV 265 V + + +L + + + SVI AP+ ++ ++ G V Sbjct: 291 LVTQLFKNEILDKLRQTTDNIGLLTLELAKNEERQQASVIRAPVSVKVQQLKVHTEGGVV 350 Query: 266 AAGSQLLYLIPQQT--WVIANFKETQIANMRIGQKAWFTVDAM---KHKKFTGHVEQISP 320 L+ ++P+ V A + I + +GQ A V+A ++ G V+ I+ Sbjct: 351 TTAETLMVIVPEDDTLEVTALVQNKDIGFINVGQNAIIKVEAFPYTRYGYLVGKVKNINL 410 Query: 321 AAGSEFSVLKPDNATGNFTKVVQRIAVRITIDPNQEGMEHLRPGMSVVTSVDT 373 A D G V+ I N+ L GM+V + T Sbjct: 411 DA-------IEDQRLGLVFNVIISIEENCLSTGNKN--IPLSSGMAVTAEIKT 454
>PYOCINKILLER#Pyocin S killer protein signature. Length = 617 Score = 29.4 bits (65), Expect = 0.049 Identities = 38/202 (18%), Positives = 63/202 (31%), Gaps = 21/202 (10%) Query: 362 AVSEAADRLGFDQISGLIAMFIHFGANILLGAVILVIGFWLANVVANVVQRGEYNSSRWL 421 A+S+A LG S M + F + L W + + S Sbjct: 280 AISDAIAVLGRVLASAPSVMAVGFAS---LTYSSRTAEQW----------QDQTPDSVRY 326 Query: 422 ASLVRVLIIGLVLALGLRAMGIADSIVNLAFGLTLGA------VAVAFALAFGLGGRQPA 475 A + +GL ++ L A+ A V+L LT A ++V + P Sbjct: 327 ALGMDAAKLGLPPSVNLNAVAKASGTVDLPMRLTNEARGNTTTLSVVSTDGVSVPKAVPV 386 Query: 476 ERLLTDLLDKAKKEANQPNPLYQPPSTTSSSAPATSTTQSTPTTPPSTAPSDAKPADSVQ 535 R+ E P+ + P + PA+ P++ P + Sbjct: 387 -RMAAYNATTGLYEVTVPSTTAEAPPLILTWTPASPPGNQNPSSTTPVVPKPVPVYEGAT 445 Query: 536 VNPAQP-PVNKPFGSTGENDEI 556 + P + P P T D I Sbjct: 446 LTPVKATPETYPGVITLPEDLI 467
>BCTERIALGSPF#Bacterial general secretion pathway protein F signature. Length = 408 Score = 405 bits (1043), Expect = e-142 Identities = 121/409 (29%), Positives = 221/409 (54%), Gaps = 12/409 (2%) Query: 9 MPTFAYDGVDRKGVKIKGELSAKNMALAKVTLRKQGVTVRNIREKRKNILEG-------L 61 M + Y +D +G K +G A + A+ LR++G+ ++ E R + + Sbjct: 1 MAQYHYQALDAQGKKCRGTQEADSARQARQLLRERGLVPLSVDENRGDQQKSGSTGLSLR 60 Query: 62 FKKKVSTLDITIFTRQLATMMKAGVPLVQGFEIVAEGLENPAMREVVLGIKGEVEGGSTF 121 K ++ST D+ + TRQLAT++ A +PL + + VA+ E P + +++ ++ +V G + Sbjct: 61 RKIRLSTSDLALLTRQLATLVAASMPLEEALDAVAKQSEKPHLSQLMAAVRSKVMEGHSL 120 Query: 122 ASALRKYPQHFDKLFCSLVESGEQSGALETMLDRVAIYKEKSELLKQKIKKAMKYPATVI 181 A A++ +P F++L+C++V +GE SG L+ +L+R+A Y E+ + ++ +I++AM YP + Sbjct: 121 ADAMKCFPGSFERLYCAMVAAGETSGHLDAVLNRLADYTEQRQQMRSRIQQAMIYPCVLT 180 Query: 182 VVAVVVTIILMVKVVPVFQDLFSSFGADLPAFTQMVVNMSKWMQEY--WFILIIVIGAII 239 VVA+ V IL+ VVP + F LP T++++ MS ++ + W +L ++ G + Sbjct: 181 VVAIAVVSILLSVVVPKVVEQFIHMKQALPLSTRVLMGMSDAVRTFGPWMLLALLAGFMA 240 Query: 240 AAFLEAKKRSKKFRDSLDKLALKLPIFGDLVYKAIIARYSRTLATTFAAGVPLIDALEST 299 + R +K R S + L LP+ G + ARY+RTL+ A+ VPL+ A+ + Sbjct: 241 FRVM---LRQEKRRVSFHRRLLHLPLIGRIARGLNTARYARTLSILNASAVPLLQAMRIS 297 Query: 300 AGATNNIIYEQAVMKIREDVATGQQLQFAMRVSNRFPSMAIQMVAIGEESGALDSMLDKV 359 +N + + V G L A+ + FP M M+A GE SG LDSML++ Sbjct: 298 GDVMSNDYARHRLSLATDAVREGVSLHKALEQTALFPPMMRHMIASGERSGELDSMLERA 357 Query: 360 ATYYENEVDNAVDGLTSMMEPLIMAILGVLVGGLVVAMYLPIFQMGSVV 408 A + E + + + EPL++ + +V +V+A+ PI Q+ +++ Sbjct: 358 ADNQDREFSSQMTLALGLFEPLLVVSMAAVVLFIVLAILQPILQLNTLM 406
>PREPILNPTASE#Type IV prepilin cysteine protease (C20) family signature. Length = 290 Score = 321 bits (825), Expect = e-113 Identities = 146/286 (51%), Positives = 187/286 (65%), Gaps = 2/286 (0%) Query: 1 MQEIIAYFIQNLTALYIAVALLSLCIGSFLNVVIYRTPKMMEQDWQQECQILLNPEQPII 60 M ++ + V L SL IGSFLNVVI+R P M+E++WQ E + NP+ + Sbjct: 1 MALLLELAHGLPWLYFSLVFLFSLMIGSFLNVVIHRLPIMLEREWQAEYRSYFNPDDEGV 60 Query: 61 DHEKLTLSKPASSCPECHQPIRWYQNIPVISWLVLKGKCGHCQHPISIRYPAVELLTMVC 120 D L P S CP C+ PI +NIP++SWL L+G+C CQ PIS RYP VELLT + Sbjct: 61 DEPPYNLMVPRSCCPHCNHPITALENIPLLSWLWLRGRCRGCQAPISARYPLVELLTALL 120 Query: 121 SLVVVMMFGPTIQMLLGLVLTWVLITLTFIDFDTQLLPDRFTLPLAALGLGINTFNIYTS 180 S+ V M P L L+LTWVL+ LTFID D LLPD+ TLPL GL N + S Sbjct: 121 SVAVAMTLAPGWGTLAALLLTWVLVALTFIDLDKMLLPDQLTLPLLWGGLLFNLLGGFVS 180 Query: 181 PNSAIWGYLIGFLCLWIVYYLFKVITGKEGMGYGDFKLLAALGAWMGPLMLPLIVLLSSL 240 A+ G + G+L LW +Y+ FK++TGKEGMGYGDFKLLAALGAW+G LP+++LLSSL Sbjct: 181 LGDAVIGAMAGYLVLWSLYWAFKLLTGKEGMGYGDFKLLAALGAWLGWQALPIVLLLSSL 240 Query: 241 LGAIIGIILLKLRNDN--QPFAFGPYIAIAGWVAFLWGDQIMKIYL 284 +GA +GI L+ LRN + +P FGPY+AIAGW+A LWGD I + YL Sbjct: 241 VGAFMGIGLILLRNHHQSKPIPFGPYLAIAGWIALLWGDSITRWYL 286
>INVEPROTEIN#Salmonella/Shigella invasion protein E (InvE) signature. Length = 372 Score = 34.3 bits (78), Expect = 3e-04 Identities = 28/91 (30%), Positives = 47/91 (51%), Gaps = 9/91 (9%) Query: 30 LKGRDDQRLQKILQLAEPFGISVQK-ASRDSLEKLAGL-PFHQGVVAAVRPHPVLNEQDL 87 L+ + ++IL+L ISV A D L + L P +V +R +L +DL Sbjct: 86 LEDEALPKAKQILKL-----ISVHGGALEDFLRQARSLFPDPSDLVLVLRE--LLRRKDL 138 Query: 88 DQILRETPDALLLALDQVTDPHNLGACIRTA 118 ++I+R+ ++LL +++ TDP L A I A Sbjct: 139 EEIVRKKLESLLKHVEEQTDPKTLKAGINCA 169
>GPOSANCHOR#Gram-positive coccus surface protein anchor signature. Length = 539 Score = 33.9 bits (77), Expect = 0.002 Identities = 42/239 (17%), Positives = 91/239 (38%), Gaps = 5/239 (2%) Query: 155 AEANDVREAYSSWQRTIRLHQAALDAQATRLQRIGTLEHQIEELEEVIQTDYKEIEQEFD 214 A A + + + + A T LE + ELE+ ++ + Sbjct: 222 ALAARKADLEKALEGAMNFSTADSAKIKTLEAEKAALEARQAELEKALEGAMNFSTADSA 281 Query: 215 RLSHHEHIMQDCSFSLNVLDEAEQNITQEISSIIRRLESHAGRSEQLSEIYNSLLNAQSE 274 ++ E L+ Q + S+ R L++ +QL + L Sbjct: 282 KIKTLEAEKAALEAEKADLEHQSQVLNANRQSLRRDLDASREAKKQLEAEHQKLEEQNKI 341 Query: 275 IDDATANLRQFIDRQSFDPERMEELNSKLEVFHRLARKYRT----QPETLKEEYETWQSE 330 + + +LR+ +D +++E + KLE ++++ R + +E + + Sbjct: 342 SEASRQSLRRDLDASREAKKQLEAEHQKLEEQNKISEASRQSLRRDLDASREAKKQVEKA 401 Query: 331 LEQLH-QLEDPETLAEQVEKSHEEFLEKAQHLDDIRREAATPLAKQLTEQVKPLALPEA 388 LE+ + +L E L +++E+S + ++ L A L ++L +Q + LA A Sbjct: 402 LEEANSKLAALEKLNKELEESKKLTEKEKAELQAKLEAEAKALKEKLAKQAEELAKLRA 460
>SECETRNLCASE#Bacterial translocase SecE signature. Length = 127 Score = 78.4 bits (193), Expect = 1e-21 Identities = 45/126 (35%), Positives = 65/126 (51%), Gaps = 5/126 (3%) Query: 21 SAEVVRSGSPLDIVLWVIAIAFLLLATMVNQYLPAYWAPANNIWVRVGAIFACIVVALGL 80 + E SG L+ + WV+ +A LL+A + N P +R A+ I A G+ Sbjct: 4 NTEAQGSGRGLEAMKWVVVVALLLVAIVGNYLYRDIMLP-----LRALAVVILIAAAGGV 58 Query: 81 LYATHQGKGFVRLLKDARVELRRVTWPTKQETVTTSWQVLLVVVVASLVLWCFDYGLGWL 140 T +GK V ++AR E+R+V WPT+QET+ T+ V V V SL+LW D L L Sbjct: 59 ALLTTKGKATVAFAREARTEVRKVIWPTRQETLHTTLIVAAVTAVMSLILWGLDGILVRL 118 Query: 141 IKLIIG 146 + I G Sbjct: 119 VSFITG 124
>BCTERIALGSPD#Bacterial general secretion pathway protein D signature. Length = 660 Score = 426 bits (1096), Expect = e-142 Identities = 225/684 (32%), Positives = 335/684 (48%), Gaps = 77/684 (11%) Query: 12 ALLAAAPLIATVSSSVYAQTWKINLRDADLTAFINEVADITGKNFAVDPRVRGNVTVISN 71 LL A L+ +++ + + + + D+ FIN V+ K +DP VRG +TV S Sbjct: 13 TLLIFAALLFRPAAA---EEFSASFKGTDIQEFINTVSKNLNKTVIIDPSVRGTITVRSY 69 Query: 72 KPLNKDEVYDLFLGVLNVNGVVAIPSGN-TIKLVPDSNVKNSGIPYDSR-NRLRGDQIVT 129 LN+++ Y FL VL+V G I N +K+V + K + +P S GD++VT Sbjct: 70 DMLNEEQYYQFFLSVLDVYGFAVINMNNGVLKVVRSKDAKTAAVPVASDAAPGIGDEVVT 129 Query: 130 RVIWLENTNPNDLIPALRPLMPQFAHMAAI--AGTNALIVSDRAANIYQLENIIRNLDGT 187 RV+ L N DL P LR L + + +N L+++ RAA I +L I+ +D Sbjct: 130 RVVPLTNVAARDLAPLLRQLNDNAGVGSVVHYEPSNVLLMTGRAAVIKRLLTIVERVDNA 189 Query: 188 GQNDIEAISLQSSQAEEIITQLEAMSATGASKDFNGARI-RIIADNRTNRILVKGDPETR 246 G + + L + A +++ + ++ + G+ + ++AD RTN +LV G+P +R Sbjct: 190 GDRSVVTVPLSWASAADVVKLVTELNKDTSKSALPGSMVANVVADERTNAVLVSGEPNSR 249 Query: 247 KRIRHMIEMLDVPSADRLGGLKVFRLKYASAKNLSEILQGLVTGQAVSSSNNNSSSNSSN 306 +RI MI+ LD A G KV LKYA A +L E+L G+ Sbjct: 250 QRIIAMIKQLDRQQA-TQGNTKVIYLKYAKASDLVEVLTGI------------------- 289 Query: 307 PINNLMGNNQNSSSNTSGSNGSSISTPSINLNGNSNNSNQNSISSFSQNGVSIIADNAQN 366 + S + + + I A N Sbjct: 290 --------SSTMQSEKQAAKPVAAL----------------------DKNIIIKAHGQTN 319 Query: 367 SLVVKADPQLMREIESAIQQLDVRRQQVLIEAAIIEVSGDDADQLGIQWALGDLSSGIGL 426 +L+V A P +M ++E I QLD+RR QVL+EA I EV D LGIQWA + G+ Sbjct: 320 ALIVTAAPDVMNDLERVIAQLDIRRPQVLVEAIIAEVQDADGLNLGIQWA----NKNAGM 375 Query: 427 LSFSNVGASLSSIAAG---YLSGGSAGAASAIAGGANKGNGATLALGNFENSRKAYGALI 483 F+N G +S+ AG Y G+ ++ A A + G A GN+ L+ Sbjct: 376 TQFTNSGLPISTAIAGANQYNKDGTVSSSLASALSSFNGIAAGFYQGNW-------AMLL 428 Query: 484 QALKSNTKSNLLSTPSIVTMDNEEAYIVVGQNVPFVTGSVTTNSTGINPYTTVERKDVGV 543 AL S+TK+++L+TPSIVT+DN EA VGQ VP +TGS TT+ N + TVERK VG+ Sbjct: 429 TALSSSTKNDILATPSIVTLDNMEATFNVGQEVPVLTGSQTTSGD--NIFNTVERKTVGI 486 Query: 544 TLKVVPHIGEGGTVRLEVEQEVSNVQTSKGQAA---DLITNKRAIKTAVLAEHGQTVVLG 600 LKV P I EG +V LE+EQEVS+V + + N R + AVL G+TVV+G Sbjct: 487 KLKVKPQINEGDSVLLEIEQEVSSVADAASSTSSDLGATFNTRTVNNAVLVGSGETVVVG 546 Query: 601 GLVSDDVELSRQGIPGLSSIPYVGRLFRSDSRSNTKRNLLVFIHPTIVGDANDVRRLSQQ 660 GL+ V + +P L IP +G LFRS S+ +KRNL++FI PT++ D ++ R+ S Sbjct: 547 GLLDKSVSDTADKVPLLGDIPVIGALFRSTSKKVSKRNLMLFIRPTVIRDRDEYRQASSG 606 Query: 661 RYNQLYSLQLAMDRNGNFAKLPEQ 684 +Y Q N + Q Sbjct: 607 QYTAFNDAQSKQRGKENNDAMLNQ 630
>BCTERIALGSPC#Bacterial general secretion pathway protein C signature. Length = 272 Score = 59.2 bits (143), Expect = 2e-12 Identities = 61/276 (22%), Positives = 103/276 (37%), Gaps = 37/276 (13%) Query: 19 LSVVVFAVLILWLCWKLASLFWWVIAP---PQMMQFDRVELGSQQPQIPNIST-FSLFNE 74 + ++F +L+L C +LA +FW + P P QQP N T F + E Sbjct: 14 IRRILFYLLMLLFCQQLAMIFWRIGLPDNAPVSSVQITPAQARQQPVTLNDFTLFGVSPE 73 Query: 75 P----------SANAAQENVNLELQGVMLGYPNRFSSAVIKLDNTADRYRVGETIGSTSY 124 +N +NL L GVM G + S A+I DN V E + + Sbjct: 74 KNKAGALDASQMSNLPPSTLNLSLTGVMAGDDDSRSIAIISKDNEQFSRGVNEEVPGYNA 133 Query: 125 QLAEVYWDHVILRQGNGSTRELQFKGLPNGLYQPMTPDASQPTATAPQSSAPVNTTQEAL 184 ++ + D V+L+ G Y+ + + + + + A VN E L Sbjct: 134 KIVSIRPDRVVLQY--------------QGRYEVLGLYSQEDSGSDGVPGAQVN---EQL 176 Query: 185 GQ-AIQQMQGNREQYLKDMGVS-GNSGGGFEVTERTPTALRNKLGLRPGDRIVSLNGQTV 242 Q A M Y+ + N G+ + + ++GL+ D V+LNG + Sbjct: 177 QQRASTTMS----DYVSFSPIMNDNKLQGYRLNPGPKSDSFYRVGLQDNDMAVALNGLDL 232 Query: 243 GQGQTDVQLLEQARRAGQVKLEIKRGDQVMTIQQNF 278 + + +E+ L ++R Q I F Sbjct: 233 RDAEQAKKAMERMADVHNFTLTVERDGQRQDIYMEF 268
>TCRTETOQM#Tetracycline resistance protein TetO/TetQ/TetM family signature. Length = 639 Score = 28.7 bits (64), Expect = 0.032 Identities = 35/161 (21%), Positives = 62/161 (38%), Gaps = 17/161 (10%) Query: 7 IGAAGYIAPRHLKAIKET-GNTLAVAMDVNDSVGIMDSHFPEAEFFTEFEE-----FEAY 60 I G + IKE + + V + ++F E+E + E E Y Sbjct: 130 IDQNGIDLSTVYQDIKEKLSAEIVIKQKVELYPNMCVTNFTESEQWDTVIEGNDDLLEKY 189 Query: 61 VEDQKLKGEKLD-----YVAICS--PNYLHAPHMKYALKNGIEVICEK---PLVLNSEDL 110 + + L+ +L+ CS P Y + + N IEVI K +L Sbjct: 190 MSGKSLEALELEQEESIRFHNCSLFPVYHGSAKNNIGIDNLIEVITNKFYSSTHRGQSEL 249 Query: 111 NMLSEYEKQYGAKVNSILQLRLHPSIIALRDKVQAAPADKI 151 ++ +Y K + +RL+ ++ LRD V+ + +KI Sbjct: 250 CGKV-FKIEYSEKRQRLAYIRLYSGVLHLRDSVRISEKEKI 289
>RTXTOXIND#Gram-negative bacterial RTX secretion protein D signature. Length = 478 Score = 32.5 bits (74), Expect = 0.006 Identities = 24/153 (15%), Positives = 54/153 (35%), Gaps = 23/153 (15%) Query: 245 QGQDKEHITKVLNAILATYSAQ------NIERRSAESA----------QTLKFLDEQLPD 288 ++ +T ++ +T+ Q N++++ AE + +L D Sbjct: 180 SEEEVLRLTSLIKEQFSTWQNQKYQKELNLDKKRAERLTVLARINRYENLSRVEKSRLDD 239 Query: 289 LKKQLDDAEREFNKFRQQYNT-VDVTKESELYLTQSITLETKKAELEQKQAEMVAKYTAE 347 L + +Q N V+ E +Y +Q +E++ +++ + + Sbjct: 240 FSSLLHKQAIAKHAVLEQENKYVEAVNELRVYKSQLEQIESEILSAKEEYQLVTQLFK-- 297 Query: 348 HPAMREINGQLAAINKQIGELNNTLKQLPDVQR 380 EI +L IG L L + + Q+ Sbjct: 298 ----NEILDKLRQTTDNIGLLTLELAKNEERQQ 326
>INFPOTNTIATR#Macrophage infectivity potentiator signature. Length = 233 Score = 152 bits (385), Expect = 6e-48 Identities = 84/218 (38%), Positives = 121/218 (55%), Gaps = 9/218 (4%) Query: 29 TTEVGSKANKNASPIEKISYVLGYEVAQQTPP---ELDTKAFVKGIHDARSKQPSAYTQE 85 T + A + +K+SY +G ++ + +++ KG+ D S T+E Sbjct: 17 TAMAATDATSLTTDKDKLSYSIGADLGKNFKNQGIDINPDVLAKGMQDGMSGAQLILTEE 76 Query: 86 ELKAAVAAYEKELQQKMQQQ-NKPEQAAGATPEAADVQFLAENKSKAGVKTTASGLQYII 144 ++K ++ ++K+L K + NK + A +A FL+ NKSK G+ SGLQY I Sbjct: 77 QMKDVLSKFQKDLMAKRSAEFNKKAEENKAKGDA----FLSANKSKPGIVVLPSGLQYKI 132 Query: 145 TKEGTGKQPTAQSIVKVHYEGRLVNGQVFDSSYKRGEPVEFPLNQVIPGWTEGLQLMKEG 204 GTG +P V V Y G L++G VFDS+ K G+P F ++QVIPGWTE LQLM G Sbjct: 133 IDAGTGAKPGKSDTVTVEYTGTLIDGTVFDSTEKAGKPATFQVSQVIPGWTEALQLMPAG 192 Query: 205 GKATFFIPSNLAYGPQEVPG-IPANSTLIFDVELISVK 241 F+P++LAYGP+ V G I N TLIF + LISVK Sbjct: 193 STWEVFVPADLAYGPRSVGGPIGPNETLIFKIHLISVK 230
>INFPOTNTIATR#Macrophage infectivity potentiator signature. Length = 233 Score = 181 bits (461), Expect = 2e-59 Identities = 94/225 (41%), Positives = 132/225 (58%), Gaps = 3/225 (1%) Query: 7 MIAASTMSLSV---FAATPITNKSPAKEQFSYSYGYLMGRNNTDALTDLNLDIFYQGLQE 63 ++ A+ M L++ AAT T+ + K++ SYS G +G+N + D+N D+ +G+Q+ Sbjct: 5 LVTAAIMGLAMSTAMAATDATSLTTDKDKLSYSIGADLGKNFKNQGIDINPDVLAKGMQD 64 Query: 64 GAQSKTARLTDEEMAKAINDYKKTLEAKQLVEFQKTGQLNAQAGAAFLADNAKKSGVITT 123 G LT+E+M ++ ++K L AK+ EF K + N G AFL+ N K G++ Sbjct: 65 GMSGAQLILTEEQMKDVLSKFQKDLMAKRSAEFNKKAEENKAKGDAFLSANKSKPGIVVL 124 Query: 124 KSGLQYQVLKEGNGQKPKATSRVKVNYEGRLLDGTVFDSSIARNHPVEFQLSQVIAGWTE 183 SGLQY+++ G G KP + V V Y G L+DGTVFDS+ P FQ+SQVI GWTE Sbjct: 125 PSGLQYKIIDAGTGAKPGKSDTVTVEYTGTLIDGTVFDSTEKAGKPATFQVSQVIPGWTE 184 Query: 184 GLQTMKEGGKTRFFIPANLAYGEVGAGDTIGPNSTLIFDIELLQV 228 LQ M G F+PA+LAYG G IGPN TLIF I L+ V Sbjct: 185 ALQLMPAGSTWEVFVPADLAYGPRSVGGPIGPNETLIFKIHLISV 229
>ACRIFLAVINRP#Acriflavin resistance protein family signature. Length = 1034 Score = 31.0 bits (70), Expect = 0.016 Identities = 32/167 (19%), Positives = 59/167 (35%), Gaps = 41/167 (24%) Query: 215 IPPKVDFKHEGVERILKL---MLPALFGVSVTQINLLLNTIWASFMQDGSVSWLYSAERM 271 +P + + G+ +L PAL +S + L L ++ S+ SV M Sbjct: 850 LPAGIGYDWTGMSYQERLSGNQAPALVAISFVVVFLCLAALYESWSIPVSV--------M 901 Query: 272 TELPLGLIGVAIGTVILPSLSARHAEQDQAKFRGMIDWAAKI--IVLVGLPASIALFMLS 329 +PLG++GV + + D + + +GL A A+ ++ Sbjct: 902 LVVPLGIVGVLLAATLFNQ---------------KNDVYFMVGLLTTIGLSAKNAILIVE 946 Query: 330 ----------TPIIQALFQRGEFDLRDTQMTALALQCMSAGVIAFML 366 +++A LR MT+LA GV+ + Sbjct: 947 FAKDLMEKEGKGVVEATLMAVRMRLRPILMTSLA---FILGVLPLAI 990
>PF07328#T-DNA border endonuclease VirD1 Length = 144 Score = 28.5 bits (63), Expect = 0.015 Identities = 9/45 (20%), Positives = 16/45 (35%) Query: 58 VNALISAYDNTVQVTWLKQEGDRVAANEAFLKLAGSARSLLTVER 102 +N + A + T + +R KL+ L+ V R Sbjct: 85 INQIAKAANRTHDPAYHSFMAERKVLGLELSKLSAVLAPLMEVSR 129
>HTHTETR#TetR bacterial regulatory protein HTH signature. Length = 215 Score = 53.1 bits (127), Expect = 8e-11 Identities = 23/72 (31%), Positives = 39/72 (54%), Gaps = 1/72 (1%) Query: 6 ERKQQSRQALLDAALHLSTSGRSFSSISLREVAREVGLVPTAFYRHFQDMDELGKELVDQ 65 + Q++RQ +LD AL L S + SS SL E+A+ G+ A Y HF+D +L E+ + Sbjct: 7 QEAQETRQHILDVALRL-FSQQGVSSTSLGEIAKAAGVTRGAIYWHFKDKSDLFSEIWEL 65 Query: 66 VALHLKSVLHQL 77 ++ + + Sbjct: 66 SESNIGELELEY 77
>HTHTETR#TetR bacterial regulatory protein HTH signature. Length = 215 Score = 56.6 bits (136), Expect = 5e-12 Identities = 17/62 (27%), Positives = 32/62 (51%), Gaps = 1/62 (1%) Query: 12 RKEKILSVAEKLLLENN-QEITLDELVAELDIAKGTLYKHFRSKNELLLELIIQNEKQIL 70 ++ IL VA +L + +L E+ + +G +Y HF+ K++L E+ +E I Sbjct: 12 TRQHILDVALRLFSQQGVSSTSLGEIAKAAGVTRGAIYWHFKDKSDLFSEIWELSESNIG 71 Query: 71 EI 72 E+ Sbjct: 72 EL 73
>BLACTAMASEA#Beta-lactamase class A signature. Length = 286 Score = 28.6 bits (64), Expect = 0.015 Identities = 14/49 (28%), Positives = 19/49 (38%), Gaps = 7/49 (14%) Query: 63 EPHMQTWLKQIPNDVRFVRTPAAMNKMWEQGARTYYTSEALGVRKRTHL 111 E + +P D R TPA+M R TS+ L R + L Sbjct: 162 ETELNEA---LPGDARDTTTPASMAATL----RKLLTSQRLSARSQRQL 203
>DHBDHDRGNASE#2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase signature. Length = 261 Score = 88.6 bits (219), Expect = 3e-23 Identities = 55/203 (27%), Positives = 89/203 (43%), Gaps = 6/203 (2%) Query: 13 LKDRIILITGAGDGIGRAAALTYALHGATVVLHGRTLNKLEVIYDEIESLGAPQPAILPL 72 ++ +I ITGA GIG A A T A GA + KLE + A P Sbjct: 6 IEGKIAFITGAAQGIGEAVARTLASQGAHIAAVDYNPEKLEKV-VSSLKAEARHAEAFPA 64 Query: 73 QLSSASDRDYDFLVDTLEKQFGRLDGILHNAGILGERVELAH-YPTETWDDVMAVNLRAP 131 + ++ D + +E++ G +D +++ AG+L R L H E W+ +VN Sbjct: 65 DVRDSAA--IDEITARIEREMGPIDILVNVAGVL--RPGLIHSLSDEEWEATFSVNSTGV 120 Query: 132 FALTQALLPLLQKSENASVVFTSSGVGREARALWGAYSVSKIAIEAVSKIFAAEHTYPNI 191 F ++++ + + S+V S R AY+ SK A +K E NI Sbjct: 121 FNASRSVSKYMMDRRSGSIVTVGSNPAGVPRTSMAAYASSKAAAVMFTKCLGLELAEYNI 180 Query: 192 RFNCINPGATRTAMRAKAYPQED 214 R N ++PG+T T M+ + E+ Sbjct: 181 RCNIVSPGSTETDMQWSLWADEN 203
>SACTRNSFRASE#Streptothricin acetyltransferase signature. Length = 173 Score = 30.7 bits (69), Expect = 0.007 Identities = 24/85 (28%), Positives = 35/85 (41%), Gaps = 10/85 (11%) Query: 367 RSAEIACVAVHPSYRKSNRGSQILQFLEEKAKEQGIRQLFVLTTR----TAHWFLEHGFH 422 A I +AV YRK G+ +L E AKE L + T H++ +H F Sbjct: 88 GYALIEDIAVAKDYRKKGVGTALLHKAIEWAKENHFCGLMLETQDINISACHFYAKHHFI 147 Query: 423 QVSVDE-----LPNAR-QALYNYQR 441 +VD P A A++ Y + Sbjct: 148 IGAVDTMLYSNFPTANEIAIFWYYK 172