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List of Environmental factors and their associated regulons

   
  Environmental factor    # Up regulated genes    # Down regulated genes 
10*3d1-N315-IP (Heteroresistance) 27 44
Acid-shock (10min) 218 231
Acid-shock (20min) 232 239
Acid-shock (2min) 69 47
Acid-shock (5min) 167 150
alpha-amyrin 2 25
Anaerobic (10min) 0 0
Anaerobic (20min) 50 2
Anaerobic (30min) 69 32
Anaerobic (60min) 110 68
Antimicrobial peptide (Dermaseptin) 96 198
Antimicrobial peptide (Ovispirin) 156 127
Antimicrobial peptide (Temporin) 167 132
Azurophilic granule proteins (120min) 328 247
Azurophilic granule proteins (15min) 420 251
Azurophilic granule proteins (30min) 264 388
Azurophilic granule proteins (60min) 322 295
Bacitracin 148 58
Berberine Chloride 484 243
Betulinaldehyde 35 173
Betulinic acid 16 8
Biofilm Vs Planktonic (early) 10 7
Biofilm Vs Planktonic (mature) 8 10
Biofilm Vs Planktonic (maturing) 11 5
Biofilm Vs Planktonic 16hr 56 30
Biofilm Vs Planktonic 24hr 39 20
Biofilm Vs Planktonic 48hr 33 14
Biofilm Vs Planktonic 6hr 25 86
Biofilm Vs Planktonic 8hr 93 149
Biofilm Vs Planktonic OD 1.0 87 252
Biofilm Vs Planktonic OD 3.5 102 204
bis-indole (MBX-1066) 4 0
bis-indole (MBX-1090) 1 0
CCCP (ATCC 29213) 365 331
Cefoxitin (N315) 11 12
Cefoxitin (N315-SaeRSmutant) 0 6
Chlorination (10 min) 286 685
Chlorination (20 min) 123 560
Ciprofloxacin (120min) 49 63
Ciprofloxacin (30min) 37 30
Cold shock 66 342
Cystic fibrosis isolate (GS-MRSA) 48 14
D-Cycloserine 320 58
Daptomycin (ATCC 29213) 142 120
Daptomycin (sensitiveVSresistant) 15 12
Daptomycin resistance 69 9
Diclofenac (COL) 116 175
Distamycin 4 0
ELB-21 (DNA binding agent) 27 31
Enduracidin (15min) 158 147
Enduracidin (60min) 225 258
Epithelial cells -2h- post internalization 343 691
Epithelial cells -6h- post internalization 165 582
Ethanol (8325-4) 94 17
Fosfomycin (1ug/ml - 10min) 2 3
Fosfomycin (1ug/ml - 20min) 10 5
Fosfomycin (1ug/ml - 40min) 139 236
Fosfomycin (4ug/ml - 10min) 5 1
Fosfomycin (4ug/ml - 20min) 42 84
Fosfomycin (4ug/ml - 40min) 341 537
Fosfomycin -murAZ-inhibition (RN4220) 71 36
Fusidic acid stimulon 272 272
Glucopyranose_12h 8 0
Glucopyranose_2h 25 0
Glucopyranose_4h 12 0
Glucopyranose_6h 9 0
Glucose (Newman) 105 81
Glycopeptide resistance (14-4 Vs 14-4Rev) 36 27
Glycopeptide resistance (14-4 Vs MRGR3) 35 32
Heat shock 98 30
HeR-HoR Selection 20 3
Human beta-defensin 3 (LTE) 18 7
Human beta-defensin 3 (STE) 44 57
hVISA-vs-VSSA (isolate pair 4) 38 28
hVISA-vs-VSSA (isolate pair 4-vancomycin) 34 58
hVISA-vs-VSSA (isolate pair 5) 27 17
hVISA-vs-VSSA (isolate pair 5-vancomycin) 15 46
Hydrogen Peroxide 10min 112 151
Hydrogen Peroxide 10min (microaerobic) 112 90
Hydrogen Peroxide 120min (MW2) 184 233
Hydrogen Peroxide 15min (MW2) 514 290
Hydrogen Peroxide 20min 95 24
Hydrogen Peroxide 30min (MW2) 365 354
Hydrogen Peroxide 60min (MW2) 276 351
Hypochlorous acid 120min (MW2) 125 68
Hypochlorous acid 15min (MW2) 295 183
Hypochlorous acid 30min (MW2) 165 208
Hypochlorous acid 60min (MW2) 71 222
Linoleic acid (0.01 mM) 34 26
Linoleic acid (0.1 mM) 208 177
Low-Fluid-Shear 34 0
Lung Adaptation 316 612
Magnolol 207 330
Mersacidin (VISA/MRSA) 72 33
Mersacidin (VISA/MSSA) 161 104
Mersacidin (VSSA/MSSA) 153 148
Mersacidin Susceptible Vs Resistance 1 31
Mild Acid 0hr 92 80
Mild Acid 3hr 143 45
Mild Acid 6hr 143 54
Mitomycin C (non-selective DNA bidning agent) 25 16
Mupirocin 320 274
Mupirocin Treatment 247 704
Nisin (ATCC 29213) 65 119
Nitrite Stress 290 348
Nitrosative and Hydrogen Peroxide (microaerobic) 132 143
Nitrosative stress 65 18
Nitrosative stress (microaerobic) 51 53
Oleic acid (0.01 mM) 18 22
Orange oil 393 454
Ortho-phenylphenol (20min) 149 356
Ortho-phenylphenol (60min) 97 316
Oxacillin 190 58
Oxacillin (SH1000) 48 42
Oxacillin (Strain 923) 79 102
Oxacillin selection 24 8
Peracetic Acid 10min 223 233
Peracetic Acid 20min 271 127
Pine-Oil Disinfectant-Reduced-Susceptibility 23 32
Rhein 54 34
Rhodomyrtone 63 35
RNAIII inhibiting peptide (RIP) 3 10
Salicylate 25 15
Sodium houttuyfonate 310 428
SOS response 70 408
Targocil 152 45
Tea Tree Oil 294 311
Teicoplanin resistance 31 18
Telavancin (15min) 149 166
Telavancin (60min) 341 337
Temperature (43C) 54 35
Temperature (48C) 288 230
Triclosan (0.05uM, 10Min) 0 4
Triclosan (0.05uM, 60Min) 20 71
Vancomycin (ATCC 29213 - 60min) 162 177
Vancomycin (ATCC 29213) 40 45
Vancomycin (N315) 113 30
Vancomycin (N315-VraSRmutant) 77 22
Vancomycin resistance (HIP5827) 78 74
Vancomycin resistance (JH1) 47 23
Vancomycin resistance (Mu50) 86 64
Vancomycin resistance (Newman) 69 41
VISA Vs h-VISA (Mu50 Vs Mu3) 18 0
VISA Vs VSSA (MI Vs MI-P) 48 1
VISA Vs VSSA (MI-PR Vs MI-P) 65 1
VISA Vs VSSA (Mu50 Vs Mu50-P) 42 0
VISA Vs VSSA (Mu50 Vs N315) 45 0
VISA Vs VSSA (Mu50-PR Vs Mu50-P) 50 0
VISA vs VSSA (USA300) 41 40
VISA-vs-VSSA (isolate pair 1) 23 8
VISA-vs-VSSA (isolate pair 1-vancomycin) 38 19
VISA-vs-VSSA (isolate pair 2) 63 30
VISA-vs-VSSA (isolate pair 2-vancomycin) 32 84
VISA-vs-VSSA (isolate pair 3) 72 49
VISA-vs-VSSA (isolate pair 3-vancomycin) 35 72
VRSA Vs VRSA (JH9 Vs JH14) 16 0
VRSA Vs VSSA (JH9 Vs JH1) 55 168
VSSA vs SCV 307 155
SATMD Staphylococcus aureus Transcriptome Meta Database, SAMMD Staphylococcus aureus Microarray Meta Database
SATMD is licensed under GNU GPL
The SATMD project is located in the Department of Biological Sciences at The University of Southern Mississippi
This project is supported by Award Number P20 GM103476 from the National Institutes of General Medical Sciences. The content is solely the responsibility of
the authors and does not necessarily represent the official views of the National Institutes of General Medical Sciences or the National Institutes of Health