isoniazid
| DRUG INFORMATION |
| Drug Name |
| isoniazid |
 |
| Synonyms |
| isoniazid, Andrazide, Cotinazin, Dinacrin, Ditubin, Atcotibine, Antimicina, Nicotibina, Tubilysin, Chemiazid, Pyridine-4-carbohydrazide,4-Pyridinecarboxylic acid hydrazide, Isonicotinic acid hydrazide,Isonicotinoyl hydrazide |
| Drug Class |
| First-Line Drugs |
| Year of Introduction |
| 1952 |
| Molecular Target |
| Mycolic acid synthesis Rv1484 Rv1908c |
| Genes Involved in Drug Resistance |
| inhA katg |
| CAS No: |
| 54-85-3 |
| PHARMACOLOGY |
| Route |
| oral |
| Side effects |
| Elevated ALT 10-20%. Clinical hepatitis 0.1-0.15% (fatal, 0.023%)age-related: < 20 yrs=nil; <35 yrs=0.1-2.0%; <45 yrs=0.2-3.0%; <55 yrs=0.3-3.5%. Rare: hypersensitivity; fever; dose-related peripheral neuropathy (<0.2%); monoamine poisoning |
| Toxicity |
| Low |
| Cost |
| Low |
| Usual Adult Dosage |
| 5mg/kg (max 300mg) PO or IM qd. DOT regimen 15mg/kg (max 900mg) 2-3x/week (3x/week in the continuation phase for HIV patients with CD4<100). |
| Form |
| tab,cab,vi |
| Brand Name |
| Isoniazid , Nydrazid ,Rifamate , Rifater |
| Manufacturer |
| Various(Aventis,Sandoz) |
| STRUCTURAL DETAILS |
| Molecular Formula |
| C6H7N3O |
| Molecular Weight in g/mol |
| 137.139 |
| Hydrogen Bond Donor Count |
| 2 |
| Hydrogen Bond Acceptor Count |
| 3 |
| Rotatable Bond Count |
| 1 |
| IUPAC Name |
| pyridine-4-carbohydrazide |
| SMILES |
| C1=CN=CC=C1C(=O)NN |
| InChI |
| 1/C6H7N3O/c7-9-6(10)5-1-3-8-4-2-5/h1-4H,7H2,(H,9,10)/f/h9H |
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