Rifabutin
| DRUG INFORMATION |
| Drug Name |
| Rifabutin |
 |
| Synonyms |
| Ansatipine,Mycobutin, Alfacid, Rifabutine, Ansatipin, Ansamycin, Assatipin, RIFABUTIN, Mycobutin (TN), Rifabutine [French] |
| CAS No: |
| 7255-06-09 |
| PHARMACOLOGY |
| Route |
| PO |
| Side effects |
| Frequent: orange discoloration of urine, tears, sweat; uveitis seen w/high doses (600mg/d or concurrent use of fluconazole or clarithromycin). Rare: neutropenia in HIV-infected pts; hepatotoxity (<1%); pseudojaundice (w/ nl bilirubin). |
| Usual Adult Dosage |
| 5mg/kg (300mg) PO qd or 2-3x/week; 450mg PO qd (with EFV co-administration); 150mg PO qd (with IDV, FPV, NFV, APV co-administration); 150mg PO qod (with RTV and LPV/r co-administration). |
| Form |
| cap |
| Brand Name |
| Mycobutin |
| Manufacturer |
| Pfizer Inc,235 East 42nd Street, New York, NY 10017, USA, Phone, 1-212-733-2323 |
| STRUCTURAL DETAILS |
| Molecular Formula |
| C46H62N4O11 |
| Molecular Weight in g/mol |
| 847.005 |
| Hydrogen Bond Donor Count |
| 5 |
| Hydrogen Bond Acceptor Count |
| 14 |
| Rotatable Bond Count |
| 5 |
| SMILES |
| Isomeric SMILES: C[C@H]1C=CC=C(C(=O)NC2=C(C3=C(C4=C(C(=C3O)C)O[C@@](C4=O)(OC=C[C@@H]([C@H]([C@H]([C@@H]([C@@H]([C@@H]([C@H]1O)C)O)C)OC(=O)C)C)OC)C)C5=NC6(CCN(CC6)CC(C)C)N=C25)O)C |
| InChI |
| 1/C46H62N4O11/c1-22(2)21-50-18-16-46(17-19-50)48-34-31-32-39(54)28(8)42-33(31)43(56)45(10,61-42)59-20-15-30(58-11)25(5)41(60-29(9)51)27(7)38(53)26(6)37(52)23(3)13-12-14-24(4)44(57)47-36(40(32)55)35(34)49-46/h12-15,20,22-23,25-27,30,37-38,41,52-55H,16-19 ,21H2,1-11H3,(H,47,57)/t23-,25+,26+,27+,30-,37-,38+,41+,45-/m0/s1/f/h47H |
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