Ethambutol
| DRUG INFORMATION |
| Drug Name |
| Ethambutol |
 |
| Synonyms |
| ethambutol, Tibutol, Aethambutolum,Diambutol, Dadibutol, D-Ethambutol, Etambutolo [DCIT], (+)-S,S-Ethambutol,Etambutol [INN-Spanish], Ethambutolum [INN-Latin], (+)- (R,R)-NN'-Ethylene bis(2-aminobutan-1-ol), (S,S)-N,N'-Ethylenebis(2-aminobutan-1-ol) Dihydrochloride, 2,2'-(1,2-Ethanediyldiimino) bis-l-butano Dihydrochloride, (+)-2,2'-(ethylenediimino) di-1-butanol Dihydrochloride, N,N'-bis(1-hydroxymethylpropyl) ethylenediamine Dihydrochloride |
| Drug Class |
| First-Line Drugs |
| Year of Introduction |
| 1968 |
| Molecular Target |
| Cell wall Synthesis Rv3794 Rv3795 Rv3793 |
| Genes Involved in Drug Resistance |
| embA,embB, embC |
| CAS No: |
| 74-55-5 |
| PHARMACOLOGY |
| Route |
| oral |
| Side effects |
| Occasional: optic neuritis (decreased acuity, reduced color discrimination, constricted fields, scotomata-dose related [25mg/kg], >risk w/daily admin and renal failure); GI intolerance. Rare: confusion; gout; skin rash; bone marrow suppress ion |
| Toxicity |
| Low |
| Cost |
| Medium |
| Usual Adult Dosage |
| 15-20mg/kg (max 2gm) qd; DOT regimen: 50mg/kg (max 4g) 2x/week or 25-30mg/kg (max 2gm) 3x/week. MAI: 15mg/kg qd (w/ macrolide). |
| Form |
| tab |
| Brand Name |
| Myambutol |
| Manufacturer |
| X-GEN, Inc., P.O. Box 445, Big Flats, NY 14814, 1.866.390.4411, info@x-gen.us |
| STRUCTURAL DETAILS |
| Molecular Formula |
| C10H24N2O2 |
| Molecular Weight in g/mol |
| 204.31 |
| Hydrogen Bond Donor Count |
| 4 |
| Hydrogen Bond Acceptor Count |
| 4 |
| Rotatable Bond Count |
| 9 |
| IUPAC Name |
| 2-[2-(1-hydroxybutan-2-ylamino)ethylamino]butan-1-ol |
| SMILES |
| CCC(CO)NCCNC(CC)CO |
| InChI |
| 1/C10H24N2O2/c1-3-9(7-13)11-5-6-12-10(4-2)8-14/h9-14H,3-8H2,1-2H3 |
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