Ethionamide
| DRUG INFORMATION |
| Drug Name |
| Ethionamide |
 |
| Synonyms |
| ethionamide,Ethioniamide, Ethyonomide, Etiocidan, Thioamide, Amidazine, Ethimide, Amidazin, Etimid, Aetiva |
| Drug Class |
| Second-Line Drugs |
| Year of Introduction |
| 1966 |
| Molecular Target |
| ? |
| Genes Involved in Drug Resistance |
| ? |
| CAS No: |
| 536-33-4 |
| PHARMACOLOGY |
| Route |
| oral |
| Side effects |
| Frequent: severe GI intolerance (n/v/metallic taste, abd pain). Occ: allergic rxns; neurotoxicity (prevented w/pyridoxine); reversible hepatitis (2%), jaundice (1-3%)--monitor LFTs q2-4 wks; gynecomastia; menstrual irregularities. |
| Toxicity |
| High |
| Cost |
| Medium |
| Usual Adult Dosage |
| 15-20mg/kg/day (max 1g/day), usually 500-750mg divided q24, q12h or q8h administered w/ food or at bedtime. |
| Form |
| tablet |
| Brand Name |
| Trecator-SC |
| Manufacturer |
| Wyeth,5 Giralda Farms, Madison, NJ 07940 |
| STRUCTURAL DETAILS |
| Molecular Formula |
| C8H10N2S |
| Molecular Weight in g/mol |
| 166.244 |
| Hydrogen Bond Donor Count |
| 1 |
| Hydrogen Bond Acceptor Count |
| 2 |
| Rotatable Bond Count |
| 2 |
| IUPAC Name |
| (2-ethylpyridin-4-yl)-imino-methanethiol |
| SMILES |
| CCC1=NC=CC(=C1)C(=N)S |
| InChI |
| 1/C8H10N2S/c1-2-7-5-6(8(9)11)3-4-10-7/h3-5H,2H2,1H3,(H2,9,11)/f/h9,11H |
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