| Gene 1 |
Gene 2 |
Interaction Type |
Sentence |
Value |
Judge me |
| 1 |
BRCA1 |
interact3 |
In this study , we demonstrate for the first time the in vitro and in vivo interaction of Elk-1 with BRCA1 splice variants BRCA1a and BRCA1b using GST-pull down assays , co-imunoprecipitations Wester |
21 |
good
bad
|
| 1 |
IGF-1 |
interact1 |
However , dephosphorylation of F-IRS-2 significantly increased phosphorylation by the IGF-1 receptor , suggesting that basal phosphorylation of IRS-2 has divergent effects on its interaction with the |
20 |
good
bad
|
| 1 |
IRS-1 |
associate3 |
Basal PI3-kinase activity , tyrosine phosphorylation of IRS-1 , and IRS-1 associated p85 levels were lower in VSMC from SHR than in cells from WKY rats . |
19 |
good
bad
|
| 1 |
Grb2 |
bind1 |
Both the catalytic activity and , to a much lesser extent , the Grb2 binding-tyrosyl phosphorylation sites of SHP-2 are required for maximal FGF-2-induced Erk activity and Elk-1 transactivation . |
18 |
good
bad
|
| 1 |
CRP |
associate3 |
CONCLUSIONS : Inflammation , as measured by CRP , and malnutrition , as measured by IGF-1 levels , are associated with mid-term mortality in HD patients . |
17 |
good
bad
|
| 1 |
IRS-1 |
associate3 |
This in turns leads to decreased IRS-1 tyrosine phosphorylation and decreased activation of IRS-1 associated PI 3 kinase resulting in decreased insulin stimulated glucose transport activity . |
17 |
good
bad
|
| 1 |
COX-2 |
complex2 |
We conclude that perivascular cells exhibit the lower threshold to COX-2 expression in response to either IL-1 or endotoxin treatment , and that enzyme expression by endothelial cells requires one or |
16 |
good
bad
|
| 1 |
PI3K |
associate1 |
Our data show that the PI3K activity associated with IRS-1 , the docking of IRS-1 to InRbeta and the docking of p85alpha to IRS-1 are attenuated in the aged Snell dwarf . |
16 |
good
bad
|
| 1 |
SAP1 |
bind2 |
We also observed binding of BRCA1 proteins to other ETS-domain transcription factors SAP1 , ETS-1 , ERG-2 and Fli-1 but not to Elk-1 splice variant DeltaElk-1 and c-Fos protooncogene . |
16 |
good
bad
|
| 1 |
Akt |
associate1 |
A dominant-negative mutant of Akt enhanced insulin-induced tyrosine phosphorylation of IRS-1 ( but not that of IRS-2 ) and its association with PI 3-kinase activity , suggesting that Akt contributes t |
15 |
good
bad
|
| 1 |
diacylglycerol |
associate1 |
Thus , increased diacylglycerol levels in muscle are associated with the activation of one or more isoforms of the protein kinase C family , which is known to attenuate insulin signaling , especially |
15 |
good
bad
|
| 1 |
IRS-1 |
associate3 |
The rate of insulin stimulated 2-deoxyglucose uptake in soleus muscle obtained from lipid-infused rats was decreased by ~ 50 % compared to controls and was paralleled by similar reductions in IRS-1 ty |
15 |
good
bad
|
| 1 |
KAP |
interact3 |
These results demonstrate that the short 224 bp fragment of the KAP promoter is sufficient to drive the proximal tubule , androgen-specific regulated expression of KAP and reveal synergistic interacti |
15 |
good
bad
|
| 1 |
A4 |
bind1 |
Inactivating mutations introduced at the A4 A3 elements , binding sites for the glucose-regulated homeodomain transcription factor PDX-1 , did not diminish the response to Ex-4 , although a marked re |
14 |
good
bad
|
| 1 |
AP-1 |
bind1 |
Thus , fusion gene transfection and proteolytic clipping gel retardation assays suggest that the AP-1 flanking sequence affects the conformation of AP-1 binding to the collagenase-1 and ME AP-1 motifs |
14 |
good
bad
|
| 1 |
IRS-1 |
associate3 |
Troglitazone significantly increased PI3-kinase activity , IRS-1 associated tyrosine phosphorylation , and IRS-1 associated p85 levels in VSMC from SHR . |
14 |
good
bad
|
| 1 |
1 |
complex1 |
Interestingly , our studies reveal that although both Elk-1 and SAP-1 are highly homologous members of a subfamily of ETS domain proteins called ternary complex factors , it is only Elk-1 but not SAP- |
13 |
good
bad
|
| 1 |
PI |
interact1 |
These data demonstrate that PI 4-kinase functions to negatively regulate GLUT4 translocation through its interaction with NCS-1 . |
13 |
good
bad
|
| 1 |
IGF |
interact3 |
Sub-library maturation in a monovalent format yielded an antagonistic peptide that inhibited the interactions between IGF-1 and two cell-surface receptors and those between IGF-1 and two soluble IGF b |
12 |
good
bad
|
| 1 |
PDX-1 |
bind1 |
These results were correlated with changes in the binding of the important transcription factor PDX-1 to the insulin promoter ; adenoviral overexpression of DN-JNK preserved PDX-1 DNA binding activity |
12 |
good
bad
|
| 1 |
Ang |
associate3 |
Troglitazone abolished Ang II-induced suppression of phosphatidilinositol 3-kinase ( PI3-kinase ) activity , insulin receptor substrate-1 ( IRS-1 ) associated tyrosine phosphorylation , and IRS-1 asso |
10 |
good
bad
|
| 1 |
phosphatidylinositol |
associate2 |
TNF-alpha , given 5 min before insulin , inhibited insulin-induced tyrosine phosphorylation of insulin receptor ( IR ) , IR substrate ( IRS ) -1 , insulin-induced association of IRS-1 with the p85 sub |
9 |
good
bad
|
| 1 |
Plasminogen |
complex2 |
Plasminogen activator inhibitor-1 ( PAI-1 ) , tissue-plasminogen activator activity and plasmin-antiplasmin complexes ( PAP ) were detected at baseline and after venous occlusion test . |
9 |
good
bad
|