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Gene 1 Gene 2 Interaction Type Sentence Value Judge me
RB BRCA1 interact1 The tumor suppressor activity of the BRCA1 gene product is due , in part , to functional interactions with other tumor suppressors , including p53 and the retinoblastoma ( RB ) protein . 18 good bad
RB BRCA1 bind1 In both in vitro and in vivo assays , we found that the BRCA1 : RB interaction does not require the BRCA1 LXCXE motif , nor does it require an intact A B binding pocket of RB . 16 good bad
Rb JNK bind1 Far Western blot analysis confirms that SAPK JNK binds directly to Rb . 16 good bad
Rb Brca1 bind1 The Brca1 promoter contains E2F DNA-binding sites that mediate transcriptional activation by E2F1 and repression by Rb . 15 good bad
Rb JNK associate1 The results demonstrate that IR activates SAPK JNK , which associates with Rb both in vivo and in vitro . 15 good bad
RB BRCA1 bind1 The N-terminal site contains a consensus RB binding motif , LXCXE ( aa 358-362 ) , but the role of this motif in RB binding and BRCA1 functional activity is unclear . 14 good bad
Rb JNK associate2 Taken together , our results suggest that Rb is a target protein of SAPK JNK and that the association of SAPK JNK and Rb mediates IR-induced apoptosis in MM cells . 14 good bad
Rb JNK interact1 Here we show that Rb can physically interact with c-Jun NH ( 2 ) -terminal kinase stress-activated protein kinase ( JNK SAPK ) , thereby inhibiting intracellular signals mediated by JNK SAPK . 14 good bad
RB aa bind1 RB binding sites on BRCA1 were identified in the C-terminal BRCT domain ( Yarden and Brody , 1999 ) and in the N-terminus ( aa 304-394 ) ( Aprelikova et al . 13 good bad
Rb Ras bind1 In addition , we present evidence that cooperation between the N-terminal fragment and Ras depends upon an intact T-antigen J domain and the ability of the T antigen to bind and inactivate the growth- 13 good bad
Rb histone complex2 The retinoblastoma suppressor ( Rb ) -associated protein 46 ( RbAp46 ) is a member of the WD-repeat protein family and a component of the histone modifying and remodeling complexes . 12 good bad
RB p130 bind1 Our findings suggest that : ( 1 ) disruption of the LXCXE motif within the N-terminal RB binding region alters the biologic function of BRCA1 ; and ( 2 ) over-expression of BRCA1 inhibits the expressi 12 good bad
RB BRCA1 bind3 Disruption of BRCA1 LXCXE motif alters BRCA1 functional activity and regulation of RB family but not RB protein binding . 11 good bad
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Text2Knowledge ... Yong Huang 2002